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chr15:40,360,741-42,749,023

Best TWAS P=1.69e-18 · Best GWAS P=7.44e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EXD1	0.04	0.04	lasso	3	0.04	8.1e-06	7.6	-7.6	2.5e-14	0.64	0.85	0.10	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NDUFAF1	0.14	0.16	bslmm	304	0.19	6.6e-23	7.3	-5.2	1.7e-07	0.48	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	NUSAP1	0.20	0.24	bslmm	311	0.24	4.6e-29	5.6	6.6	3.2e-11	-0.59	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	OIP5-AS1	0.21	0.23	lasso	5	0.26	3.7e-21	6.8	6.4	1.8e-10	-0.60	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	OIP5-AS1	0.23	0.16	lasso	10	0.11	2.8e-06	5.2	5.9	3.0e-09	-0.60	0.98	0.01	FALSE
6	GTEx	Adrenal Gland	OIP5-AS1	0.17	0.16	lasso	3	0.16	2.6e-06	5.6	5.4	7.2e-08	-0.51	0.78	0.04	FALSE
7	GTEx	Artery Aorta	OIP5-AS1	0.16	0.21	enet	26	0.23	5.2e-13	6.7	7.5	7.5e-14	-0.69	0.99	0.01	FALSE
8	GTEx	Artery Coronary	OIP5-AS1	0.12	0.13	lasso	2	0.14	2.3e-05	5.2	5.4	6.5e-08	-0.56	0.50	0.24	FALSE
9	GTEx	Artery Tibial	OIP5-AS1	0.16	0.23	lasso	4	0.24	3.6e-19	6.8	6.5	6.0e-11	-0.60	1.00	0.00	FALSE
10	GTEx	Brain Caudate basal ganglia	NUSAP1	0.31	0.38	lasso	9	0.40	1.1e-12	5.9	6.6	3.5e-11	-0.58	0.99	0.01	FALSE
11	GTEx	Brain Cerebellar Hemisphere	NUSAP1	0.24	0.31	lasso	6	0.22	2.0e-06	5.7	6.5	6.7e-11	-0.60	0.64	0.29	FALSE
12	GTEx	Brain Cerebellar Hemisphere	NDUFAF1	0.20	0.23	lasso	6	0.22	2.2e-06	6.5	-6.0	1.8e-09	0.55	0.80	0.02	FALSE
13	GTEx	Brain Cerebellum	OIP5	0.16	0.09	lasso	4	0.16	1.8e-05	5.7	7.4	1.4e-13	-0.74	0.18	0.42	FALSE
14	GTEx	Brain Cerebellum	NUSAP1	0.22	0.23	enet	18	0.22	3.7e-07	5.9	6.2	7.7e-10	-0.55	0.90	0.03	FALSE
15	GTEx	Brain Cerebellum	NDUFAF1	0.24	0.26	lasso	8	0.20	1.1e-06	6.1	-7.1	1.3e-12	0.59	0.64	0.34	FALSE
16	GTEx	Brain Cortex	NUSAP1	0.43	0.25	enet	27	0.26	8.7e-08	5.9	5.7	1.0e-08	-0.55	0.97	0.02	FALSE
17	GTEx	Brain Cortex	NDUFAF1	0.40	0.37	enet	22	0.36	7.0e-11	7.3	-6.7	1.6e-11	0.59	0.99	0.01	FALSE
18	GTEx	Brain Cortex	GCHFR	0.25	0.04	enet	15	0.05	1.4e-02	6.2	-6.4	1.8e-10	0.50	0.04	0.66	FALSE
19	GTEx	Brain Cortex	OIP5-AS1	0.25	0.01	enet	11	0.03	6.1e-02	6.3	5.6	2.2e-08	-0.25	0.04	0.06	FALSE
20	GTEx	Brain Frontal Cortex BA9	OIP5	0.13	0.00	enet	16	0.01	2.1e-01	1.3	6.7	1.5e-11	-0.41	0.04	0.46	FALSE
21	GTEx	Brain Frontal Cortex BA9	NUSAP1	0.39	0.42	enet	22	0.42	2.0e-12	5.9	7.4	1.5e-13	-0.68	0.90	0.10	FALSE
22	GTEx	Brain Frontal Cortex BA9	NDUFAF1	0.55	0.37	lasso	8	0.40	1.6e-11	5.4	-6.3	2.3e-10	0.61	0.99	0.01	FALSE
23	GTEx	Brain Hippocampus	NUSAP1	0.30	0.25	enet	14	0.26	1.0e-06	5.7	7.2	8.7e-13	-0.68	0.18	0.62	FALSE
24	GTEx	Brain Hypothalamus	NUSAP1	0.26	0.36	lasso	4	0.27	5.6e-07	7.8	7.5	5.2e-14	-0.64	0.41	0.51	FALSE
25	GTEx	Brain Hypothalamus	NDUFAF1	0.24	0.12	lasso	5	0.13	5.9e-04	6.1	-6.2	6.4e-10	0.61	0.08	0.69	TRUE
26	GTEx	Brain Nucleus accumbens basal ganglia	NUSAP1	0.36	0.32	lasso	6	0.26	1.5e-07	5.4	6.7	2.2e-11	-0.65	0.66	0.32	FALSE
27	GTEx	Brain Nucleus accumbens basal ganglia	NDUFAF1	0.12	0.11	lasso	6	0.10	9.7e-04	6.5	-7.1	8.9e-13	0.60	0.32	0.15	FALSE
28	GTEx	Brain Putamen basal ganglia	NUSAP1	0.38	0.30	lasso	20	0.34	9.1e-09	5.9	6.0	1.5e-09	-0.56	0.95	0.02	FALSE
29	GTEx	Breast Mammary Tissue	OIP5-AS1	0.20	0.24	lasso	7	0.22	1.8e-11	6.8	7.5	4.5e-14	-0.71	0.91	0.09	FALSE
30	GTEx	Breast Mammary Tissue (Male)	OIP5-AS1	0.26	0.10	enet	20	0.22	7.3e-06	6.6	7.9	2.1e-15	-0.63	0.22	0.44	FALSE
31	GTEx	Breast Mammary Tissue (Female)	OIP5-AS1	0.28	0.31	lasso	3	0.29	3.0e-09	6.8	7.7	1.0e-14	-0.75	0.15	0.85	FALSE
32	GTEx	Cells EBV-transformed lymphocytes	NDUFAF1	0.35	0.46	enet	14	0.51	3.1e-19	6.1	-7.2	4.9e-13	0.63	1.00	0.00	FALSE
33	GTEx	Cells EBV-transformed lymphocytes	OIP5-AS1	0.21	0.12	lasso	7	0.10	3.2e-04	5.4	5.2	1.9e-07	-0.46	0.28	0.05	FALSE
34	GTEx	Cells Transformed fibroblasts	NDUFAF1	0.26	0.15	lasso	8	0.20	2.8e-15	6.0	-6.9	4.0e-12	0.61	1.00	0.00	FALSE
35	GTEx	Cells Transformed fibroblasts	CHP1	0.13	0.11	lasso	6	0.11	2.1e-08	6.3	-7.1	8.7e-13	0.55	1.00	0.00	FALSE
36	GTEx	Cells Transformed fibroblasts	OIP5-AS1	0.28	0.32	lasso	2	0.32	3.5e-24	5.4	5.3	1.0e-07	-0.55	1.00	0.00	FALSE
37	GTEx	Colon Sigmoid	NDUFAF1	0.15	0.06	lasso	4	0.06	5.2e-03	7.5	-8.6	9.9e-18	0.73	0.12	0.70	FALSE
38	GTEx	Colon Sigmoid	OIP5-AS1	0.21	0.27	lasso	3	0.25	3.3e-09	5.4	5.5	3.2e-08	-0.55	0.98	0.02	FALSE
39	GTEx	Colon Transverse	OIP5-AS1	0.13	0.14	lasso	5	0.15	1.8e-07	5.4	6.1	1.2e-09	-0.58	0.97	0.02	FALSE
40	GTEx	Esophagus Gastroesophageal Junction	NDUFAF1	0.19	0.13	lasso	5	0.16	1.8e-06	7.3	-6.1	9.7e-10	0.55	0.14	0.86	FALSE
41	GTEx	Esophagus Gastroesophageal Junction	OIP5-AS1	0.18	0.10	lasso	7	0.11	8.9e-05	5.4	6.0	2.5e-09	-0.51	0.69	0.06	FALSE
42	GTEx	Esophagus Mucosa	NDUFAF1	0.25	0.18	enet	26	0.24	4.3e-16	7.5	-6.9	6.1e-12	0.63	0.99	0.01	FALSE
43	GTEx	Esophagus Mucosa	CHP1	0.19	0.10	lasso	7	0.09	1.4e-06	7.6	-7.8	5.2e-15	0.75	0.79	0.21	FALSE
44	GTEx	Esophagus Mucosa	OIP5-AS1	0.20	0.22	lasso	6	0.20	1.7e-13	5.9	6.3	3.9e-10	-0.54	1.00	0.00	FALSE
45	GTEx	Esophagus Muscularis	NDUFAF1	0.24	0.23	lasso	5	0.28	2.8e-17	5.2	-6.4	1.6e-10	0.60	1.00	0.00	FALSE
46	GTEx	Esophagus Muscularis	OIP5-AS1	0.24	0.24	enet	19	0.28	4.6e-17	5.4	6.1	9.3e-10	-0.60	1.00	0.00	FALSE
47	GTEx	Heart Atrial Appendage	NDUFAF1	0.36	0.28	enet	24	0.34	9.5e-16	6.3	-6.6	5.2e-11	0.60	1.00	0.00	FALSE
48	GTEx	Heart Atrial Appendage	RTF1	0.14	0.07	lasso	4	0.08	2.4e-04	6.1	-5.5	4.9e-08	0.36	0.44	0.10	FALSE
49	GTEx	Heart Left Ventricle	NDUFAF1	0.49	0.62	lasso	8	0.62	2.0e-41	6.1	-6.1	1.2e-09	0.54	1.00	0.00	FALSE
50	GTEx	Lung	OIP5-AS1	0.09	0.08	enet	14	0.12	2.8e-09	7.7	8.4	6.4e-17	-0.74	0.35	0.65	FALSE
51	GTEx	Muscle Skeletal	NDUFAF1	0.44	0.56	enet	31	0.60	3.0e-73	6.1	-6.8	7.9e-12	0.62	1.00	0.00	FALSE
52	GTEx	Nerve Tibial	OIP5	0.07	0.08	lasso	2	0.05	1.6e-04	6.3	6.6	3.6e-11	-0.47	0.77	0.12	TRUE
53	GTEx	Nerve Tibial	NUSAP1	0.15	0.09	enet	10	0.15	9.8e-11	5.6	7.6	4.3e-14	-0.67	0.97	0.03	FALSE
54	GTEx	Nerve Tibial	NDUFAF1	0.36	0.43	lasso	6	0.43	8.0e-33	5.9	6.1	1.3e-09	-0.53	1.00	0.00	FALSE
55	GTEx	Nerve Tibial	OIP5-AS1	0.20	0.22	enet	21	0.26	1.3e-18	5.2	5.9	3.6e-09	-0.60	1.00	0.00	FALSE
56	GTEx	Pancreas	NDUFAF1	0.41	0.39	enet	20	0.42	2.7e-19	6.1	6.2	5.2e-10	-0.55	1.00	0.00	FALSE
57	GTEx	Pancreas	OIP5-AS1	0.07	0.13	lasso	2	0.10	7.5e-05	6.8	6.6	3.5e-11	-0.62	0.53	0.17	FALSE
58	GTEx	Pituitary	NUSAP1	0.16	0.12	lasso	2	0.16	7.4e-05	5.9	6.8	8.9e-12	-0.63	0.14	0.74	TRUE
59	GTEx	Prostate	NDUFAF1	0.30	0.12	lasso	2	0.14	2.7e-04	6.6	6.9	3.7e-12	-0.53	0.27	0.07	FALSE
60	GTEx	Prostate	OIP5-AS1	0.26	0.03	lasso	9	0.09	2.5e-03	6.8	6.0	1.5e-09	-0.54	0.08	0.19	FALSE
61	GTEx	Skin Not Sun Exposed Suprapubic	NDUFAF1	0.16	0.06	lasso	3	0.07	1.7e-04	7.5	-6.8	9.4e-12	0.55	0.05	0.53	FALSE
62	GTEx	Skin Not Sun Exposed Suprapubic	OIP5-AS1	0.17	0.19	enet	17	0.22	4.3e-12	5.7	6.7	2.2e-11	-0.61	1.00	0.00	FALSE
63	GTEx	Skin Sun Exposed Lower leg	DNAJC17	0.08	0.04	enet	9	0.02	5.6e-03	5.1	5.9	3.5e-09	-0.30	0.15	0.21	FALSE
64	GTEx	Skin Sun Exposed Lower leg	INO80	0.09	0.00	enet	24	0.03	3.1e-03	5.3	5.7	1.4e-08	-0.31	0.64	0.12	FALSE
65	GTEx	Skin Sun Exposed Lower leg	CHP1	0.06	0.04	enet	9	0.04	3.1e-04	7.7	-7.7	1.3e-14	0.69	0.36	0.32	FALSE
66	GTEx	Skin Sun Exposed Lower leg	OIP5-AS1	0.13	0.17	lasso	3	0.23	5.0e-19	6.7	6.7	2.1e-11	-0.60	1.00	0.00	FALSE
67	GTEx	Testis	OIP5-AS1	0.14	0.16	lasso	1	0.14	8.6e-07	6.8	6.8	1.3e-11	-0.62	0.63	0.24	FALSE
68	GTEx	Thyroid	OIP5	0.06	0.03	lasso	5	0.02	1.1e-02	5.6	5.5	4.2e-08	-0.55	0.38	0.22	FALSE
69	GTEx	Thyroid	NDUFAF1	0.25	0.21	lasso	6	0.22	9.3e-17	6.2	6.6	4.1e-11	-0.53	1.00	0.00	FALSE
70	GTEx	Thyroid	RTF1	0.28	0.27	lasso	3	0.26	8.4e-20	-8.5	-8.6	8.4e-18	0.91	0.03	0.97	FALSE
71	GTEx	Thyroid	OIP5-AS1	0.20	0.19	lasso	8	0.20	4.1e-15	6.8	6.9	4.5e-12	-0.62	1.00	0.00	FALSE
72	GTEx	Whole Blood	NDUFAF1	0.25	0.07	lasso	6	0.12	6.4e-11	6.3	6.1	1.3e-09	-0.51	0.99	0.00	FALSE
73	METSIM	Adipose	NUSAP1	0.03	0.03	lasso	6	0.02	4.2e-04	5.6	5.6	2.1e-08	-0.52	0.66	0.05	FALSE
74	NTR	Blood	INO80	0.02	0.02	enet	8	0.03	2.8e-09	6.6	-7.0	3.0e-12	0.55	1.00	0.00	FALSE
75	NTR	Blood	NUSAP1	0.03	0.03	lasso	3	0.04	4.9e-12	5.7	5.7	1.3e-08	-0.52	1.00	0.00	FALSE
76	NTR	Blood	RTF1	0.04	0.02	blup	338	0.03	6.9e-09	-7.9	8.4	5.7e-17	-0.68	0.19	0.81	TRUE
77	YFS	Blood	MGA	0.01	0.00	blup	454	0.00	7.1e-02	5.8	6.9	6.4e-12	-0.58	0.10	0.25	FALSE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHP	0.01	0.01	blup	54	0.01	1.4e-02	7.9	-8.5	2.9e-17	0.75	0.01	0.86	TRUE
79	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC729082	0.02	0.01	blup	44	0.02	2.9e-04	6.9	-6.9	5.2e-12	0.69	0.10	0.84	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NUSAP1	0.03	0.01	blup	40	0.02	3.4e-03	5.4	-6.8	7.5e-12	0.66	0.05	0.78	FALSE
81	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INO80	0.03	0.02	blup	38	0.03	1.1e-02	4.5	6.3	2.5e-10	-0.42	0.04	0.19	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	NDUFAF1	0.03	0.04	lasso	3	0.04	3.2e-05	5.8	-5.9	4.3e-09	0.52	0.34	0.65	FALSE
83	The Cancer Genome Atlas	Lung Adenocarcinoma	NDUFAF1	0.14	0.17	lasso	5	0.18	9.6e-21	6.1	5.6	2.7e-08	-0.48	0.95	0.05	FALSE
84	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LOC729082	0.06	0.01	enet	6	0.03	3.3e-04	8.0	-5.9	4.1e-09	0.55	0.01	0.77	FALSE
85	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INO80	0.07	0.04	blup	40	0.06	1.2e-03	5.2	6.4	1.8e-10	-0.49	0.05	0.52	FALSE
86	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC729082	0.31	0.00	blup	43	0.00	5.5e-01	2.8	5.3	1.5e-07	-0.30	0.02	0.30	TRUE
87	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NDUFAF1	0.23	0.15	lasso	3	0.13	3.7e-06	5.6	5.9	4.6e-09	-0.56	0.41	0.57	FALSE
88	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NDUFAF1	0.18	0.21	blup	28	0.22	5.4e-09	6.1	5.3	1.2e-07	-0.47	0.74	0.26	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC729082	0.04	0.07	lasso	1	0.06	5.5e-07	5.7	-5.7	1.1e-08	0.53	0.94	0.05	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	NDUFAF1	0.13	0.16	enet	8	0.17	2.2e-17	6.1	6.1	8.6e-10	-0.49	0.95	0.05	FALSE
91	The Cancer Genome Atlas	Testicular Germ Cell Tumors	EXD1	0.33	0.04	enet	12	0.12	6.1e-05	6.6	6.0	1.7e-09	-0.50	0.02	0.67	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	INO80	0.03	0.02	blup	39	0.03	1.0e-03	4.2	6.2	5.1e-10	-0.49	0.21	0.48	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	NDUFAF1	0.32	0.38	enet	11	0.39	1.2e-39	6.1	5.5	3.1e-08	-0.49	0.94	0.06	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	RTF1	0.04	0.02	lasso	3	0.02	4.0e-03	-8.5	-8.8	1.7e-18	0.91	0.00	0.98	TRUE