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chr2:101,617,631-104,049,356

Best TWAS P=0 · Best GWAS P=4.68e-272 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	IL1R1	0.14	0.09	lasso	3	0.10	4.0e-12	-11.44	12.1	9.2e-34	-0.13	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IL1RL2	0.18	0.05	bslmm	549	0.09	1.8e-11	-16.16	-10.4	2.1e-25	-0.09	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SLC9A2	0.17	0.10	lasso	4	0.11	4.7e-13	18.95	17.1	1.2e-65	-0.16	1.00	0.00	FALSE
4	GTEx	Brain Caudate basal ganglia	IL18R1	0.17	0.23	lasso	6	0.20	1.6e-06	9.68	-9.7	2.9e-22	0.17	0.80	0.01	FALSE
5	GTEx	Brain Cerebellar Hemisphere	IL18R1	0.25	0.25	enet	9	0.10	1.8e-03	6.46	-7.7	1.1e-14	0.12	0.40	0.03	FALSE
6	GTEx	Brain Cortex	IL18R1	0.21	0.12	lasso	9	0.13	1.7e-04	9.68	-6.6	4.4e-11	0.09	0.46	0.06	FALSE
7	GTEx	Brain Putamen basal ganglia	IL1RL1	0.24	0.12	lasso	8	0.21	8.7e-06	9.68	-10.8	4.0e-27	0.27	0.12	0.15	FALSE
8	GTEx	Brain Putamen basal ganglia	IL18R1	0.30	0.22	enet	21	0.24	1.8e-06	9.68	-8.6	7.7e-18	0.14	0.58	0.02	FALSE
9	GTEx	Breast Mammary Tissue	MAP4K4	0.14	0.09	enet	16	0.08	7.6e-05	5.41	10.1	3.7e-24	-0.19	0.22	0.04	FALSE
10	GTEx	Colon Transverse	IL18R1	0.14	0.00	enet	41	0.00	2.1e-01	9.24	27.5	3.4e-166	-0.45	0.06	0.18	FALSE
11	GTEx	Lung	IL1RL1	0.31	0.20	lasso	6	0.20	2.3e-15	9.70	-8.3	9.1e-17	0.23	1.00	0.00	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	IL1R2	0.29	0.17	lasso	7	0.13	1.7e-07	6.11	7.1	1.4e-12	0.02	0.99	0.00	FALSE
13	GTEx	Skin Sun Exposed Lower leg	IL1R2	0.29	0.07	lasso	12	0.12	1.5e-10	6.11	7.6	2.7e-14	-0.03	1.00	0.00	FALSE
14	GTEx	Thyroid	IL18R1	0.08	0.00	enet	7	0.00	3.5e-01	-8.08	9.6	6.0e-22	-0.47	0.14	0.22	FALSE
15	GTEx	Uterus	IL18R1	0.26	0.08	lasso	4	0.02	1.0e-01	4.29	8.8	1.2e-18	-0.27	0.08	0.09	TRUE
16	GTEx	Whole Blood	IL18R1	0.06	0.00	enet	14	0.01	2.1e-02	-35.21	22.3	1.1e-109	-0.79	0.02	0.91	FALSE
17	GTEx	Whole Blood	IL18RAP	0.14	0.18	lasso	10	0.18	6.0e-16	1.03	-5.3	9.0e-08	0.50	1.00	0.00	FALSE
18	GTEx	Whole Blood	MFSD9	0.40	0.50	lasso	4	0.50	1.1e-52	-5.30	-5.2	1.9e-07	0.09	1.00	0.00	FALSE
19	NTR	Blood	IL18R1	0.05	0.02	bslmm	582	0.02	5.1e-07	6.50	14.4	8.6e-47	-0.32	0.98	0.02	FALSE
20	NTR	Blood	IL18RAP	0.14	0.16	lasso	7	0.19	1.1e-59	30.33	-20.1	3.1e-90	0.60	1.00	0.00	FALSE
21	NTR	Blood	IL1R2	0.02	0.01	lasso	3	0.01	3.5e-05	9.97	8.5	1.9e-17	-0.19	0.97	0.00	FALSE
22	NTR	Blood	MFSD9	0.05	0.06	lasso	2	0.05	1.8e-14	-4.79	-5.2	2.6e-07	0.03	1.00	0.00	TRUE
23	ROSMAP	Brain Pre-frontal Cortex	IL1RL2	0.08	0.02	enet	33	0.03	2.3e-04	9.79	-19.4	1.6e-83	0.19	0.20	0.04	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	IL1RL1	0.45	0.51	enet	20	0.51	4.8e-77	9.70	-11.1	1.3e-28	0.24	1.00	0.00	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	IL18R1	0.42	0.52	lasso	5	0.52	6.2e-78	9.68	-9.6	5.7e-22	0.17	1.00	0.00	TRUE
26	YFS	Blood	IL18RAP	0.41	0.55	bslmm	562	0.62	4.2e-269	30.33	-21.2	2.4e-99	0.62	1.00	0.00	FALSE
27	YFS	Blood	IL1R2	0.05	0.05	bslmm	507	0.05	1.5e-16	6.43	7.5	9.1e-14	-0.21	1.00	0.00	TRUE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL1RL1	0.04	0.03	lasso	7	0.03	8.1e-04	-35.19	-35.0	2.7e-268	0.91	0.01	0.96	TRUE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL18R1	0.05	0.01	blup	108	0.03	1.8e-07	-35.24	24.0	1.7e-127	-0.78	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL1RL1	0.02	0.01	blup	78	0.01	1.5e-03	33.99	-33.4	4.4e-245	0.68	0.10	0.53	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	MAP4K4	0.02	0.00	blup	67	0.01	3.7e-03	1.83	6.0	1.5e-09	-0.09	0.04	0.36	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	IL1R2	0.10	0.04	lasso	6	0.04	3.2e-03	10.07	-10.2	3.2e-24	0.08	0.16	0.07	TRUE
33	The Cancer Genome Atlas	Glioblastoma Multiforme	IL18RAP	0.34	0.02	blup	94	0.08	1.5e-03	-12.80	-16.9	7.9e-64	0.45	0.02	0.14	TRUE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL1R2	0.03	0.01	blup	87	0.02	2.5e-03	10.04	-11.5	9.3e-31	0.25	0.01	0.80	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL1RL1	0.04	0.04	lasso	8	0.04	1.7e-05	-34.10	-39.4	0.0e+00	0.81	0.03	0.93	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL18R1	0.06	0.01	blup	108	0.04	2.6e-05	-10.28	-10.0	1.0e-23	-0.20	0.10	0.04	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL18RAP	0.03	0.02	blup	94	0.02	1.2e-03	-35.24	34.3	2.5e-258	-0.81	0.00	0.93	TRUE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL1RL1	0.08	0.08	enet	9	0.08	1.2e-09	-34.13	-38.5	0.0e+00	0.61	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL1RL2	0.04	0.04	enet	5	0.03	1.9e-04	-28.33	-28.9	9.2e-184	0.37	0.06	0.41	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IL1RL1	0.18	0.06	blup	78	0.15	3.7e-09	33.99	-39.7	0.0e+00	0.59	0.62	0.37	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL1RL1	0.13	0.20	enet	8	0.20	4.5e-22	9.70	-9.7	2.4e-22	0.17	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	IL1RL1	0.03	0.01	blup	78	0.02	4.7e-03	-32.37	-42.1	0.0e+00	0.76	0.09	0.43	TRUE
43	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IL1R2	0.20	0.03	enet	14	0.04	1.7e-03	7.27	12.2	5.1e-34	-0.16	0.03	0.22	TRUE
44	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IL1R2	0.32	0.08	enet	10	0.20	1.3e-08	10.40	-7.9	2.4e-15	-0.01	0.55	0.36	TRUE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IL1RL1	0.19	0.05	blup	78	0.10	7.1e-05	34.28	-39.3	0.0e+00	0.84	0.02	0.93	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	IL1R1	0.36	0.19	enet	28	0.23	1.1e-23	-23.39	20.5	1.3e-93	-0.40	0.96	0.04	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	IL1R1	0.07	0.00	blup	156	0.01	9.7e-02	0.92	-6.7	2.3e-11	0.25	0.04	0.03	FALSE
48	The Cancer Genome Atlas	Stomach Adenocarcinoma	IL1R2	0.07	0.05	lasso	3	0.06	2.5e-05	10.29	-11.3	1.4e-29	0.12	0.87	0.04	TRUE
49	The Cancer Genome Atlas	Thyroid Carcinoma	IL1RL1	0.05	0.03	enet	6	0.03	9.7e-04	-34.13	-34.2	1.1e-256	0.51	0.65	0.12	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	SLC9A2	0.05	0.01	blup	93	0.02	8.6e-03	10.85	11.9	8.0e-33	-0.08	0.02	0.81	TRUE