Hub : Genes

MFSD9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.3340	0.1160	3.4e-03	0.163	NA	0.074	NA	0.078	5.8e-05	NA	6.1e-03	NA	4.8e-03
2	GTEx	Whole Blood	0.3990	0.0480	0.0e+00	0.499	NA	0.491	NA	0.501	2.3e-52	NA	3.0e-51	NA	1.1e-52
3	METSIM	Adipose	0.0980	0.0273	3.2e-10	0.049	0.076	0.070	0.074	0.076	6.5e-08	1.6e-11	1.2e-10	3.6e-11	1.9e-11
4	NTR	Blood	0.0514	0.0148	9.2e-11	0.055	0.029	0.040	0.044	0.045	2.8e-17	1.2e-09	6.6e-13	3.8e-14	1.7e-14
5	YFS	Blood	0.0940	0.0217	1.1e-16	0.030	0.056	0.072	0.072	0.070	4.0e-10	6.9e-18	1.5e-22	1.4e-22	7.7e-22
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0773	0.0366	3.6e-04	0.024	0.039	0.034	NA	0.038	8.2e-04	3.3e-05	9.1e-05	NA	4.2e-05
7	TCGA	Brain Lower Grade Glioma	0.0719	0.0324	6.7e-04	0.039	0.039	0.043	NA	0.049	2.7e-05	2.5e-05	1.2e-05	NA	3.0e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.3	0.4	-0.5	-1.1	-1.0	-0.6	0.6	-0.4
Bipolar Disorder or Schizophrenia	1.2	2.9	6.7	-0.8	-2.0	-1.7	-2.6	-1.9	1.8	-0.1
Depressed Affect (Nagel 2018)	1.0	2.1	4.5	-2.1	-1.5	-0.9	-1.3	-1.7	1.0	1.1
Depression (Nagel 2018)	0.1	0.2	0.4	-0.4	-0.5	0.1	0.0	-0.6	0.6	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.6	-0.1	0.0	0.9	1.3	0.4	0.4	-0.1
Neuroticism (Nagel 2018)	1.3	3.0	4.6	-2.1	-2.1	-1.0	-1.3	-2.1	1.8	1.3
Schizophrenia (2018)	1.5	3.1	6.2	-1.4	-2.2	-1.2	-2.5	-1.9	1.8	0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	1.3	-1.1	-0.2	-0.5	0.2	0.0	-0.6	0.2
Worry (Nagel 2018)	0.9	1.9	3.3	-0.7	-1.5	-1.1	-0.8	-1.8	1.8	1.5
Alzheimer’s Disease (in mother)	0.4	0.4	0.8	-0.6	-0.7	-0.4	-0.9	-0.4	0.7	-0.8
Alzheimer’s Disease (in father)	0.7	0.8	1.4	-1.0	-1.2	-0.8	-1.0	-1.0	0.8	0.0
Alzheimer’s Disease (including proxy)	0.9	1.3	2.2	-1.0	-1.5	-1.1	-1.4	-1.0	0.8	-1.0
Crohns Disease (2017)	0.3	0.8	1.8	0.5	0.4	-0.4	1.4	0.9	-1.2	-0.6
Irritable Bowel Disease (IBD)	0.3	0.8	2.4	-0.1	0.2	-0.4	0.9	1.0	-1.6	-1.0
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.6	-0.4	-0.2	-0.2	0.2	-0.5	-0.5
Major Depression (MDD)	0.5	0.5	1.9	-0.5	0.1	1.1	0.2	0.0	1.4	0.6
Reaction Time	0.1	0.2	0.6	-0.8	-0.5	-0.7	-0.3	-0.3	0.2	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.4	0.2	-0.4	0.4	0.4	0.5	0.3
Breast Cancer	0.4	0.9	2.0	0.8	1.1	0.6	1.4	1.4	-0.5	-0.3
Ovarian Cancer	0.1	0.2	0.6	-0.7	-0.3	0.1	0.8	-0.0	-0.1	0.0
Prostate Cancer	0.8	1.1	3.4	1.9	1.4	0.8	0.5	0.9	-0.6	0.3
Age at First Birth	0.2	0.3	1.3	-0.3	-0.5	0.6	-0.3	-0.1	-0.6	-1.1
Bipolar Disorder (2011)	2.9	2.8	5.4	-1.3	-2.3	-1.9	-2.1	-1.8	1.1	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.0	0.7	0.9	1.0	1.0	0.5	-1.0	0.1
Coronary Artery Disease (CAD)	1.2	1.4	2.1	-1.3	-1.5	-1.4	-1.3	-1.4	0.6	-0.4
Crohns Disease (2012)	0.2	0.3	1.2	0.6	0.3	-0.4	0.3	0.6	-1.1	-0.5
Mean Putamen Volume	1.3	1.5	2.4	-1.5	-1.5	-1.2	-1.4	-1.4	0.9	0.2
Fasting Glucose	1.3	1.6	2.3	1.5	1.2	1.2	0.9	1.3	-1.5	-1.0
HbA1C	0.7	0.8	2.1	0.2	0.8	1.1	0.7	0.7	-1.5	-0.4
HDL Cholesterol	0.9	1.5	4.5	-0.1	0.0	0.8	0.6	1.2	-1.8	-2.1
LDL Cholesterol	0.6	1.0	1.5	0.8	1.0	1.0	1.1	1.2	-1.0	-0.5
Lupus	2.0	3.0	4.6	-1.2	-1.7	-2.0	-1.7	-2.1	2.0	0.7
Neuroticism (2016)	0.1	0.1	0.4	-0.1	-0.1	0.1	-0.3	-0.6	0.0	0.5
Primary Biliary Cirrhosis	0.0	0.1	0.2	-0.2	0.3	-0.3	-0.0	0.1	-0.4	0.1
Rheumatoid Arthritis	0.1	0.2	0.5	0.7	0.5	0.4	0.4	0.2	0.0	-0.1
Schizophrenia (2014)	1.9	4.2	10.3	-1.7	-2.7	-1.9	-3.2	-1.9	0.8	-1.1
Triglycerides	1.1	1.9	3.0	1.6	1.7	1.1	1.6	1.5	-1.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.5	-0.2	-0.2	-0.5	-0.7	-0.2	-0.3	-0.5
Ulcerative Colitis	0.5	0.7	2.9	-0.6	-0.2	-0.5	-0.1	0.6	-1.7	-1.0
Blood Eosinophil Count	1.8	13.8	27.1	-3.1	-5.2	1.8	-5.2	-4.1	-2.3	-2.9
Blood Platelet Count	0.1	1.6	2.7	-0.5	0.8	1.3	1.1	1.4	-1.6	-1.6
Blood Red Count	0.3	2.8	5.1	2.2	2.2	1.0	2.3	1.7	-0.1	0.9
Blood White Count	0.6	4.3	9.9	-3.1	-2.8	-0.1	-2.4	-2.1	1.4	0.4
Heel T-Score	0.0	0.2	0.4	0.6	0.3	0.2	0.5	0.4	-0.4	-0.3
BMI	0.2	1.1	2.2	-0.8	-0.7	-1.4	-1.0	-0.2	-1.5	-1.1
Height	0.2	4.6	9.0	3.0	2.6	2.2	2.8	1.3	-0.4	1.4
Waist Hip Ratio (WHR)	0.2	0.9	4.2	0.2	0.5	0.5	0.4	0.9	-2.1	-0.9
Systolic Blood Pressure	0.3	1.3	1.9	1.4	1.1	1.2	1.0	1.1	-1.3	-0.4
Smoking Status	0.1	0.3	0.7	-0.6	-0.8	-0.1	-0.7	-0.1	0.2	-0.7
Allergy or Eczema	1.6	4.1	9.0	-2.4	-2.9	0.4	-3.0	-2.1	-0.5	-0.8
Cardiovascular Disease	0.6	1.9	4.0	1.5	1.3	2.0	1.3	1.1	-1.5	-0.7
Hypothyroidism (self reported)	0.3	0.7	1.5	-1.2	-1.0	-0.6	-1.0	-0.3	0.0	-0.9
Respiratory disease	0.9	2.0	3.5	-1.5	-1.7	1.8	-1.5	-1.9	-0.5	-0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.2	0.5	0.1	-0.1	0.0	-0.2	0.1	0.2
Lung FEV1/FVC ratio	0.4	1.9	7.7	-0.0	-1.2	-2.8	-1.2	-0.6	1.6	-0.0
Lung FVC	0.1	0.4	1.1	-0.3	-0.6	-0.6	-1.0	-0.5	-0.4	-0.8
Neuroticism	0.8	2.0	3.2	-1.8	-1.6	-0.9	-1.6	-1.5	1.2	1.1
Chronotype (morning person)	0.9	2.0	4.9	1.4	2.2	0.4	1.8	1.2	-1.4	0.1
Hair Pigment	0.1	1.6	3.7	1.1	1.9	0.5	1.6	1.3	-0.9	0.7
Tanning	0.1	1.4	2.4	-1.4	-1.5	-0.8	-1.5	-1.5	0.4	-0.4
Hand grip strength (left)	0.7	1.8	2.8	-1.5	-1.7	-1.7	-1.7	-0.8	-0.5	-1.0
Number of treatments/medications taken	0.5	0.8	2.4	-0.8	0.0	1.3	0.6	0.3	-1.6	-0.8
Average weekly spirits intake	3.7	4.6	8.7	1.8	1.6	3.0	1.7	2.1	-2.6	-1.7
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.2	-0.6	0.3	-0.7	-0.6	0.5	0.3
Frequency of depressed mood in last 2 weeks	1.8	2.5	5.3	1.8	1.5	2.3	1.8	1.4	-1.0	0.4
Hearing difficulty/problems: Yes	1.0	1.5	2.7	0.7	1.1	1.7	1.0	1.5	-1.6	-0.8
Relative age of first facial hair	1.2	2.5	4.5	-1.7	-1.8	-0.8	-1.9	-1.5	2.1	0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	1.0	-1.0	0.0	0.0	0.3	0.3	-0.3	0.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.2	0.2	1.0	0.2	1.5	0.7	-0.7	0.2
Ever had hysterectomy (womb removed)	3.5	4.0	7.2	1.2	2.0	2.7	2.4	2.3	-1.7	-1.1
Systolic blood pressure, automated reading	0.2	0.6	1.5	0.5	0.5	0.2	0.2	0.8	-1.2	-1.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.9	-1.4	-0.9	-0.4	-0.9	-0.4	0.7	-0.1
Angina	0.4	0.6	2.5	-0.3	-0.0	0.6	-0.0	0.3	-1.6	-1.0
Medication for hormone replacement therapy	1.8	2.0	3.5	1.4	1.2	1.4	1.9	1.7	-0.8	-1.2
Vitamin and mineral supplements	0.5	0.7	1.3	1.1	-0.1	-0.4	-0.6	-0.9	1.1	1.1
Supplements: Zinc	0.5	0.5	2.0	-0.1	0.1	1.4	0.7	0.8	-0.4	-0.6
Medication: Co-codamol	0.4	0.4	1.8	-0.8	0.3	0.2	0.4	0.3	-1.3	-0.3
Medication: Metformin	0.2	0.2	0.6	0.8	0.6	0.2	0.4	0.2	0.4	0.5
Diabetes (father)	0.7	0.9	4.8	-0.2	0.1	-0.2	0.6	-0.0	2.2	1.1
Diabetes (mother)	3.1	3.9	6.3	2.5	2.1	2.2	2.2	2.2	-1.6	-0.4
Severe depression (siblings)	1.0	1.1	1.7	-1.2	-1.0	-1.2	-1.3	-0.9	1.2	-0.0
Pack years adult smoking proportion	0.4	0.6	2.5	-0.1	-0.6	-0.3	0.1	0.5	-0.9	-1.6
Impedance of leg (right)	0.3	1.4	5.2	0.3	0.9	1.0	1.1	0.1	1.3	2.3
Leg fat-free mass (left)	0.1	0.6	1.9	0.0	-0.4	-0.6	-0.5	-0.1	-1.4	-1.4
Trunk fat percentage	0.3	1.3	2.6	-0.6	-0.6	-1.5	-1.0	-0.0	-1.6	-1.6
Hand grip strength (right)	0.5	1.4	2.5	-1.5	-1.5	-1.2	-1.6	-0.9	0.1	-0.8
Townsend deprivation index at recruitment	1.3	1.8	3.5	-1.2	-1.7	-1.0	-1.9	-1.7	0.9	0.5
Current tobacco smoking	0.2	0.4	0.8	-0.9	-0.6	-0.3	-0.5	-0.3	0.8	0.6
Average weekly fortified wine intake	1.2	1.5	2.9	0.7	1.0	1.6	1.3	1.7	-1.0	-0.7
Maternal smoking around birth	0.7	1.0	2.3	-1.0	-0.9	-1.5	-0.6	-1.4	0.1	0.8
Fed-up feelings	0.7	1.3	2.2	-1.5	-1.0	-0.3	-1.2	-1.2	1.3	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.8	-1.3	-1.4	-0.9	-1.3	-1.3	0.6	0.8
Relative age voice broke	1.3	1.9	5.0	-1.1	-0.5	-1.2	-0.7	-1.3	1.8	2.2
Taking other prescription medications	0.4	0.6	2.6	-1.6	-0.5	1.1	0.1	-0.4	0.2	0.1
Age when periods started (menarche)	1.1	2.6	4.2	1.8	1.9	1.6	2.1	0.8	0.6	2.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.2	0.6	0.5	1.1	0.7	0.3	0.8	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	5.8	1.7	1.1	1.4	1.1	1.7	-2.0	-2.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.9	1.4	0.8	0.3	0.4	0.6	0.1	0.2
Qualifications: CSEs or equivalent	0.8	1.1	2.2	-0.1	-1.3	-1.1	-1.2	-1.5	0.9	0.4
Serious illness, injury or assault to yourself	0.1	0.2	0.4	-0.0	0.3	0.6	0.6	0.2	-0.5	0.1
High blood pressure	0.2	0.7	2.1	0.5	0.4	0.6	0.3	0.5	-1.4	-1.1
Hayfever, allergic rhinitis or eczema	1.1	2.5	4.8	-2.1	-2.2	0.7	-2.2	-1.6	-0.2	-0.5
Multivitamins +/- minerals	1.0	1.3	2.9	-0.3	0.6	0.9	0.9	1.1	-1.7	-1.6
Stomach or abdominal pain in last month	3.2	4.0	6.8	-2.1	-2.6	-1.2	-2.2	-2.4	2.1	0.7
Supplements: Glucosamine	0.4	0.5	1.2	-1.1	-0.5	-0.6	0.1	0.2	-1.1	-0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.2	0.0	0.2	0.3	0.4	-0.0	-0.2	1.1
Medication: Atenolol	0.6	0.7	2.3	1.5	0.9	0.3	0.8	0.0	-0.5	1.0
Medication: Levothyroxine sodium	0.3	0.5	1.3	-0.6	-1.1	-0.1	-1.1	-0.5	0.5	-0.6
Sitting height	0.2	1.2	3.0	1.7	1.3	1.2	1.2	0.6	-0.5	0.4
Chronic bronchitis/emphysema (father)	2.9	3.4	6.7	2.6	2.0	2.5	1.9	1.3	-0.8	0.8
High blood pressure (mother)	0.2	0.3	1.1	0.4	-0.1	0.6	-0.1	0.5	-0.2	-1.1
Body mass index (BMI)	0.5	2.3	5.8	-1.0	-1.1	-1.6	-1.5	-0.2	-1.9	-2.4
Impedance of leg (left)	0.3	1.4	4.7	0.4	0.9	1.1	1.2	0.2	1.3	2.2
Leg predicted mass (left)	0.1	0.6	1.8	0.0	-0.4	-0.6	-0.6	-0.1	-1.4	-1.3
Trunk fat mass	0.2	1.0	2.8	-0.3	-0.4	-1.2	-0.8	0.0	-1.7	-1.5
Waist circumference	0.4	1.3	4.9	-0.2	0.1	-0.6	-0.1	0.7	-2.2	-1.9
Number of incorrect matches in round	4.5	7.4	13.2	-2.8	-2.9	-3.6	-3.0	-2.9	2.0	0.9
Past tobacco smoking	0.2	0.4	1.7	0.7	0.5	-0.3	0.2	-0.4	0.5	1.3
Alcohol usually taken with meals	1.1	1.8	5.6	-0.8	0.1	-0.5	0.2	1.4	-2.4	-2.1
Nervous feelings	0.3	0.5	1.6	0.5	0.2	0.9	0.7	0.1	0.6	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.2	0.1	0.1	0.7	0.0	-0.5	0.2	1.1
Hearing difficulty/problems with background noise	2.3	3.7	7.0	1.6	1.8	2.6	2.2	2.3	-1.5	-0.8
Hair/balding pattern: Pattern 2	1.2	1.5	3.7	-1.1	-1.2	-1.9	-1.2	-0.4	-1.0	-1.3
Had menopause	4.8	5.9	10.0	2.2	3.0	2.3	3.2	2.7	-2.2	-0.1
Had other major operations	1.8	2.2	3.2	1.4	1.5	1.6	1.8	1.8	-1.2	-1.1
Forced vital capacity (FVC)	0.1	0.4	0.8	-0.0	-0.3	-0.4	-0.3	-0.9	0.7	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	3.2	0.2	0.4	0.2	0.4	0.9	-0.8	-1.8
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	6.4	-1.9	-2.3	-1.9	-2.5	-1.3	0.4	-1.8
Qualifications: None of the above	0.6	1.4	2.3	1.0	1.5	1.4	1.3	1.3	-0.9	0.3
Financial difficulties in last 2 years	0.6	0.8	1.9	-1.4	-1.0	-0.3	-0.9	-0.9	0.3	0.9
Mouth/teeth dental problems	0.2	0.2	0.9	-0.2	-0.2	-0.5	-0.4	-0.5	1.0	0.3
Heart attack	0.8	1.0	5.0	-0.0	0.0	-0.5	-0.3	0.3	-2.2	-1.4
Allergy	1.8	4.2	8.2	2.7	2.9	-1.1	2.6	2.4	-0.3	0.0
Pain all over the body in last month	0.2	0.2	0.7	0.2	0.1	-0.2	0.0	0.4	-0.8	-0.4
Diabetes (self-reported)	0.1	0.1	0.3	-0.3	-0.3	0.1	-0.3	0.1	0.5	-0.5
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.1	0.5	0.6	1.4	0.6	0.3	-1.0	-0.2
Medication: Ramipril	0.2	0.2	0.6	-0.4	-0.4	-0.5	-0.7	-0.2	-0.3	-0.4
Medication: Simvastatin	0.3	0.4	1.2	-1.1	-0.6	-0.5	-0.8	-0.2	-0.1	-0.7
Fluid intelligence score	0.2	0.4	1.6	-0.8	-0.7	-0.2	-0.4	-0.1	1.2	-0.2
Illnesses of siblings	0.1	0.1	0.4	-0.3	-0.1	-0.7	-0.0	-0.1	0.0	0.6
Neuroticism score	0.6	1.3	2.2	-1.3	-1.1	-0.5	-1.1	-1.3	0.8	1.5
Weight	0.2	1.0	2.9	-0.2	-0.3	-0.8	-0.6	0.1	-1.7	-1.7
Impedance of arm (right)	0.2	0.8	2.7	0.3	0.3	0.1	0.4	-0.4	1.5	1.6
Arm fat percentage (right)	0.7	2.6	5.7	-1.1	-1.4	-1.9	-1.8	-0.4	-1.6	-2.4
Trunk fat-free mass	0.0	0.2	0.8	0.1	-0.0	-0.1	0.0	-0.1	-0.9	-0.5
Hip circumference	0.2	0.8	3.2	0.2	0.2	-0.4	-0.1	0.6	-1.4	-1.8
Time employed in main current job	0.5	0.6	1.7	-0.8	-0.0	-0.7	0.1	-0.6	1.1	1.3
Alcohol intake versus 10 years previously	1.0	1.5	3.5	-0.6	-0.7	-0.7	-0.7	-1.6	1.7	1.9
Father’s age at death	0.4	0.5	1.7	-0.1	0.2	0.3	0.4	0.1	1.3	1.1
Worrier / anxious feelings	0.5	0.9	3.3	0.3	0.1	1.0	0.5	-0.3	1.3	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.2	-0.2	0.0	0.1	-0.1	-0.3	-0.4	0.3
Falls in the last year	0.3	0.4	0.8	0.0	0.7	0.4	0.9	0.6	-0.8	0.4
Hair/balding pattern: Pattern 3	1.4	2.1	4.4	2.1	1.4	2.0	1.3	1.3	-0.6	0.1
Number of live births	3.5	5.0	6.8	2.6	2.4	2.5	2.3	2.5	-1.4	-1.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.9	0.6	0.0	-0.7	-0.2	-0.7	0.9	0.9
Pulse rate	0.5	0.8	1.7	-0.4	-0.7	-0.7	-0.8	-1.3	1.0	1.1
Happiness	0.5	0.7	1.3	-1.1	-0.8	-0.9	-1.0	-0.4	-0.0	-0.8
Noisy workplace	0.1	0.1	0.3	-0.0	-0.1	0.2	-0.2	-0.5	-0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.3	-1.0	-1.0	-1.8	-1.1	-0.7	-0.5	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.6	-0.3	-0.6	-0.4	-0.5	0.1	0.7	-1.3
Mouth/teeth dental problems: Dentures	0.1	0.2	0.7	0.2	0.5	0.8	0.5	0.3	-0.6	0.2
Asthma	1.1	2.2	2.9	-0.9	-1.7	1.7	-1.6	-1.3	-1.6	-1.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.5	-0.2	0.1	0.5	0.6	-0.1	0.3	0.7
Medication: Cholesterol lowering	0.2	0.3	0.9	-0.3	-0.5	-0.4	-0.7	-0.3	-0.5	-0.9
Depression (self-reported)	0.3	0.3	1.0	-1.0	-0.7	-0.5	-0.5	-0.4	0.5	-0.0
Medication: Lansoprazole	0.6	0.7	2.1	0.5	0.4	1.4	0.8	1.0	-0.7	-0.5
Prospective memory result	0.8	1.0	2.7	-0.1	-0.6	-0.1	-0.9	-1.2	1.6	1.2
Lung cancer (father)	0.5	0.6	2.2	-1.5	-0.6	-0.3	-0.8	-0.3	0.7	-0.3
Illnesses of mother	1.4	1.8	5.6	-1.0	-0.6	-0.8	-0.6	-1.6	1.4	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.5	0.3	-0.2	-0.7	-0.4	-0.9	0.9	1.2
Pulse wave Arterial Stiffness index	2.5	2.9	5.5	2.3	2.3	1.3	2.1	1.4	-0.8	0.8
Impedance of arm (left)	0.2	0.7	2.2	0.4	0.5	0.3	0.6	-0.3	1.4	1.5
Arm fat mass (right)	0.4	1.6	3.8	-0.8	-0.9	-1.5	-1.2	-0.2	-1.6	-1.9
Trunk predicted mass	0.0	0.2	1.1	0.2	0.1	0.0	0.1	0.1	-1.1	-0.7
Standing height	0.2	1.5	2.7	1.5	1.4	1.4	1.6	0.5	0.3	1.2
Length of working week for main job	2.2	2.4	3.9	-1.4	-1.2	-1.6	-1.2	-1.9	2.0	1.5
Exposure to tobacco smoke at home	1.9	2.1	5.2	1.3	1.5	1.8	2.3	1.6	-0.0	0.2
Breastfed as a baby	0.4	0.5	1.4	-1.0	-0.5	-1.2	-0.4	0.1	-0.3	-0.7
Tense / ‘highly strung’	0.2	0.3	0.8	-0.3	-0.7	-0.9	-0.5	-0.4	-0.3	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.9	0.4	0.0	1.1	0.4	0.9	-0.8	-1.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.6	-0.3	-0.1	-0.3	-0.0	-0.6	0.9	1.3
Birth weight of first child	0.5	0.9	2.1	-0.2	-0.7	-1.0	-0.7	-1.5	1.1	1.1
Peak expiratory flow (PEF)	0.4	1.0	1.9	-0.4	-0.7	-1.3	-0.8	-1.2	1.4	0.9
Pulse wave reflection index	0.9	1.2	1.8	0.9	1.0	0.5	1.2	1.4	-1.3	-0.9
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.7	-1.9	-1.1	-1.2	-1.1	-0.4	-0.7	-1.2
Loud music exposure frequency	2.0	2.2	4.2	2.0	1.5	1.5	1.4	1.4	-1.1	-1.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.2	-1.4	-1.5	-2.1	-1.9	-1.6	0.4	-0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	-0.1	-0.6	0.1	-0.5	-0.2	0.0	-0.3
Blood clot in the leg (DVT)	0.5	0.6	1.9	0.5	1.0	0.5	1.4	1.1	0.1	0.0
Medication: Paracetamol	0.2	0.3	1.5	-0.2	0.2	1.2	0.5	0.2	-0.3	-0.3
Headache pain in last month	0.1	0.2	0.8	0.3	0.2	0.5	0.3	0.4	-0.9	-0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.2	0.3	0.4	0.1	0.6	0.0	1.8	1.5
Glaucoma (self-reported)	0.7	0.8	3.9	-1.0	-0.4	-0.2	-0.4	0.4	-2.0	-0.7
Gout (self-reported)	0.6	0.8	1.3	1.1	0.7	0.7	0.8	1.0	-0.7	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.6	-1.2	-1.1	-0.3	-1.1	-0.6	0.3	-0.6
Medication: Amlodipine	0.7	0.9	1.9	0.6	0.7	0.7	0.8	1.1	-1.2	-1.4
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.4	-0.9	-1.1	0.2	-1.0	-1.2	-0.6	-0.4
Birth weight	0.2	0.5	1.4	1.2	0.4	0.7	0.4	-0.0	0.9	0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.3	-1.1	-0.7	-0.9	-0.4	-0.7	-0.5	-0.9
High blood pressure (siblings)	0.3	0.5	0.8	0.6	0.6	0.5	0.7	0.7	-0.9	-0.8
Forced vital capacity (FVC), Best measure	0.1	0.4	1.1	-0.0	-0.3	-0.1	-0.4	-1.0	0.8	1.1
Body fat percentage	0.4	1.6	3.4	-0.7	-0.8	-1.5	-1.1	-0.0	-1.7	-1.9
Leg fat percentage (right)	0.3	1.2	3.4	-0.5	-0.4	-1.1	-0.8	0.2	-1.9	-1.6
Arm fat-free mass (right)	0.1	0.6	2.6	0.4	0.4	0.2	0.4	0.5	-1.6	-0.9
Exposure to tobacco smoke outside home	0.7	0.9	2.7	-1.1	-0.8	-1.6	-0.7	-0.6	-0.5	-0.7
Comparative body size at age 10	0.6	1.6	3.3	-1.2	-1.4	-1.8	-1.5	-0.9	-0.6	-0.9
Number of full brothers	0.3	0.4	1.1	-0.7	-0.5	0.3	-0.5	-0.6	1.1	0.2
Worry too long after embarrassment	0.2	0.3	0.8	-0.6	-0.6	-0.4	-0.3	-0.5	0.0	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	3.2	-0.3	-1.1	0.2	-0.4	0.3	0.1	-1.8
Wheeze or whistling in the chest in last year	1.4	2.5	4.8	-2.1	-2.1	0.2	-2.0	-2.2	0.0	0.1
Number of children fathered	1.2	1.4	4.7	0.3	-0.0	-0.1	-0.4	0.7	-2.2	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	0.5	0.7	0.9	0.8	0.9	-1.4	-0.3
Age at first live birth	0.4	0.7	1.3	-0.8	-1.1	-0.7	-1.1	-0.8	0.8	0.1
Pulse wave peak to peak time	1.9	2.2	4.1	-2.0	-2.0	-1.1	-1.8	-1.2	0.9	-0.7
Health satisfaction	0.2	0.3	0.8	-0.5	-0.4	0.0	-0.5	-0.5	-0.9	-0.7
Shortness of breath walking on level ground	0.4	0.5	1.3	-0.0	0.5	0.8	0.4	0.7	-1.1	-0.7
Qualifications: College or University degree	0.4	1.4	5.3	0.5	0.2	1.1	0.3	1.4	-1.1	-2.3
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.6	-0.4	-0.5	-0.5	-0.7	0.9	0.1
Mouth/teeth dental problems: Loose teeth	4.3	5.1	8.0	-2.5	-2.6	-2.8	-2.5	-2.4	1.6	-0.0
Emphysema/chronic bronchitis	2.4	2.7	4.2	-1.9	-1.6	-0.4	-1.4	-2.0	1.8	1.7
Medication for pain relief, constipation, heartburn	0.1	0.2	0.9	1.0	0.2	-0.2	-0.2	0.1	0.3	-0.2
Neck or shoulder pain in last month	0.3	0.4	0.7	0.6	0.5	0.6	0.4	0.5	-0.7	-0.8
Medication: Blood pressure	0.6	1.0	4.9	0.3	0.0	0.3	-0.0	0.3	-2.2	-1.3
Angina (self-reported)	0.3	0.4	2.0	-0.3	-0.1	0.4	-0.2	0.0	-1.4	-0.7
Migraine (self-reported)	2.7	3.4	5.2	1.8	2.0	2.3	2.2	1.7	-1.8	-0.3
Medication: Ibuprofen	0.4	0.5	1.4	0.0	0.6	0.9	1.2	0.7	-0.3	0.6
Medication: Allopurinol	0.3	0.4	1.1	-0.6	-0.9	-0.3	-0.7	-0.2	0.5	-1.1
Medication: Omeprazole	0.6	0.7	1.2	0.3	0.9	1.0	1.1	0.5	0.9	1.0
Medication: Seretide 50 evohaler	0.3	0.3	0.7	-0.3	-0.5	0.8	-0.7	-0.4	-0.6	-0.4
Mean time to correctly identify matches	0.1	0.1	0.4	-0.7	-0.0	-0.6	0.2	0.2	0.2	0.0
Heart disease (mother)	1.5	1.8	7.9	-0.3	-0.2	-0.9	-0.2	1.2	-1.6	-2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.5	0.2	0.6	0.1	0.7	0.2	0.6	0.7
Whole body fat mass	0.3	1.1	2.7	-0.4	-0.6	-1.0	-0.9	0.0	-1.6	-1.6
Leg fat mass (right)	0.3	1.0	3.1	-0.2	-0.4	-0.9	-0.7	0.2	-1.8	-1.6
Arm predicted mass (right)	0.1	0.6	2.7	0.5	0.4	0.2	0.3	0.4	-1.6	-0.8
Pulse rate, automated reading	0.6	1.9	3.3	1.8	1.8	1.2	1.5	1.2	-1.4	-0.4
Alcohol intake frequency.	0.2	0.5	1.8	-0.2	-0.2	-0.8	-0.2	-0.7	0.8	1.4
Comparative height size at age 10	0.0	0.2	0.5	-0.1	-0.3	-0.2	0.0	-0.3	-0.7	-0.7
Number of full sisters	0.4	0.4	0.8	0.7	0.5	0.4	0.8	-0.3	0.8	0.9
Suffer from ‘nerves’	0.5	0.8	1.9	-0.6	-0.9	-1.4	-0.9	-1.3	-0.0	0.5
Overall health rating	0.8	1.7	2.6	-1.5	-1.0	-1.2	-0.9	-1.5	1.3	1.6
Chest pain or discomfort	0.5	0.8	2.6	-0.4	0.5	1.6	0.6	-0.2	0.4	1.3
Had major operations	0.3	0.3	0.8	-0.3	0.1	0.9	0.4	0.5	-0.9	-0.0
Age at last live birth	0.7	1.0	2.9	-0.4	-1.1	-0.2	-1.1	-1.1	1.7	0.4
Family relationship satisfaction	1.1	1.3	2.8	-1.0	-1.3	-1.2	-1.7	-1.0	0.7	-1.1
Leg pain on walking	0.4	0.5	1.0	-0.7	-0.6	-0.6	-0.5	-0.9	1.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	-0.6	-1.2	-0.5	-1.1	-0.8	-0.3	-0.5
Commuting to job workplace: Car/motor vehicle	2.1	2.4	5.2	1.6	1.8	2.3	1.6	1.4	-1.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	0.6	0.5	0.5	0.3	0.3	0.1	0.3
Medication: Aspirin	1.4	1.8	6.8	-0.3	-0.2	-0.3	-0.2	0.9	-2.6	-2.2
Supplements: Vitamin C	1.2	1.4	3.2	-1.8	-1.1	-1.0	-1.1	-1.3	0.8	1.1
Knee pain experienced in last month	1.2	1.9	5.0	0.8	1.3	0.4	1.4	1.6	-2.2	-1.1
Hypertension (Self-reported)	0.4	1.2	2.6	1.0	0.8	1.2	0.8	0.9	-1.6	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.2	-0.4	0.1	-0.2	-0.3	0.4	0.3
Illnesses of father: Heart disease	0.6	0.8	2.4	0.6	1.1	0.1	1.2	0.2	0.0	1.5
Illnesses of siblings: Diabetes	1.6	1.9	3.5	-1.4	-1.5	-1.9	-1.7	-1.3	1.1	-0.3
Smoking status: Previous	0.5	0.7	2.8	0.2	0.0	0.5	0.3	0.8	-1.1	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.2	0.2	0.2	0.2	0.4	-0.6	0.3	1.1
Whole body fat-free mass	0.1	0.4	1.5	0.1	-0.1	-0.2	-0.2	0.0	-1.2	-1.0
Leg fat-free mass (right)	0.1	0.5	1.5	0.1	-0.4	-0.7	-0.6	-0.2	-1.1	-1.2
Arm fat percentage (left)	0.6	2.5	5.5	-1.0	-1.3	-1.9	-1.7	-0.4	-1.7	-2.4
Average weekly red wine intake	1.6	2.4	4.9	-2.2	-1.7	-1.2	-1.6	-0.5	-0.4	-2.0
Handedness (chirality/laterality): Left-handed	2.2	2.6	4.1	-0.8	-1.7	-0.7	-1.8	-1.9	2.0	1.8
Mood swings	1.5	2.6	5.1	-2.3	-1.5	-1.3	-1.6	-1.7	0.9	1.7
Loneliness, isolation	0.1	0.2	0.5	-0.2	-0.3	0.7	-0.4	-0.2	-0.4	-0.3
Long-standing illness, disability or infirmity	0.4	0.5	1.7	-0.6	0.0	1.3	0.3	0.7	-0.2	-1.1
Ever had bowel cancer screening	0.6	0.7	1.3	0.9	1.1	0.2	1.2	1.1	-0.1	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.4	0.3	0.4	0.4	0.2	0.6	-0.1	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.4	-1.2	-1.1	-0.3	-0.8	-1.0	1.1	0.4
Friendships satisfaction	0.2	0.3	0.6	0.4	-0.4	-0.7	-0.8	-0.6	0.6	0.1
Qualifications: nursing, teaching	2.4	3.7	7.7	-2.1	-2.2	-2.8	-2.2	-1.5	1.0	-0.9
Commuting to job workplace: Walk	0.2	0.3	0.4	-0.5	-0.6	-0.6	-0.5	-0.3	-0.4	-0.6
Eye problems/disorders: Cataract	0.6	0.7	1.6	0.1	0.7	0.1	1.0	1.2	-0.8	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	1.7	-1.3	-1.1	-1.3	-0.9	-1.1	0.7	0.6
Medication for cholesterol	0.5	0.8	1.8	-0.7	-0.7	-0.5	-0.7	-0.9	1.0	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	-0.9	-1.3	-0.5	-0.6	-0.8	0.2	-0.6
Back pain experienced in last month	0.0	0.1	0.2	-0.4	-0.2	-0.3	-0.1	0.0	-0.4	-0.1
Mineral and other dietary supplements	0.2	0.3	0.7	0.9	0.6	0.5	0.5	0.2	0.1	0.4
Breast cancer (self-reported)	0.1	0.1	0.3	0.2	0.4	0.2	0.1	0.1	-0.5	-0.0
Asthma (self-reported)	1.2	2.3	3.7	-1.1	-1.9	1.5	-1.8	-1.5	-1.4	-1.2
Osteoporosis (self-reported)	0.1	0.1	0.5	-0.4	0.3	0.5	0.3	-0.0	0.1	0.7
Osteoarthritis (self-reported)	1.9	2.5	5.3	0.9	1.1	1.3	1.6	2.0	-2.3	-1.4
Medication: Aspirin	0.8	1.0	3.5	-0.3	-0.4	-0.3	-0.4	0.4	-1.9	-1.7
Medication: Gliclazide	0.1	0.1	0.3	0.6	-0.1	-0.3	-0.2	-0.4	-0.3	0.1
Illnesses of father: None of the above (group 1)	0.9	1.1	3.1	-0.8	-1.2	-0.9	-1.8	-0.8	0.3	-0.9
Smoking status: Current	0.5	0.8	1.4	-1.2	-1.0	-0.5	-1.0	-0.6	1.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	1.2	-0.8	-1.0	-0.4	-1.1	-0.8	-0.2	0.5
Whole body water mass	0.1	0.4	1.7	0.0	-0.1	-0.2	-0.2	0.0	-1.3	-1.0
Leg predicted mass (right)	0.1	0.6	1.6	-0.0	-0.5	-0.7	-0.7	-0.2	-1.1	-1.3
Arm fat mass (left)	0.4	1.5	3.8	-0.7	-0.9	-1.4	-1.2	-0.2	-1.6	-1.9
Number of self-reported non-cancer illnesses	1.0	1.7	6.2	-2.5	-1.2	-0.5	-1.0	-0.8	-1.3	-0.7
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.7	0.5	1.1	0.3	0.1	-0.4	0.3
Miserableness	2.2	3.8	6.3	-2.5	-2.1	-1.2	-2.3	-2.2	1.6	1.4
Guilty feelings	0.7	1.1	3.2	-1.8	-1.4	-0.3	-1.1	-1.0	0.3	0.3
Wears glasses or contact lenses	1.8	2.1	4.4	1.1	1.6	1.8	1.7	2.1	-0.7	-0.4
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.6	-0.8	-0.2	-0.6	-0.4	-0.3	0.2
Hearing aid user	1.4	1.6	3.1	0.7	1.8	1.6	1.8	1.2	-0.7	0.5
Mother’s age at death	0.9	1.1	2.0	1.4	1.1	0.6	1.1	1.4	-0.6	-0.6
Financial situation satisfaction	2.5	3.1	7.4	-2.7	-2.1	-1.4	-2.0	-0.9	-0.8	-1.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.7	-0.2	0.2	0.2	-0.1	0.2	-0.8	-0.4
Commuting to job workplace: Public transport	0.2	0.3	1.5	0.1	-0.3	-0.6	-0.4	0.1	-0.2	-1.2
Eye problems/disorders: Glaucoma	0.6	0.8	3.8	-0.7	-0.1	0.2	-0.3	0.5	-1.9	-0.9
Medication: Blood pressure	0.2	0.4	0.9	1.0	0.7	0.8	0.8	0.4	0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	-1.0	0.4	-0.2	0.6	-0.1	0.7	1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	-0.9	-0.8	-0.2	-1.0	-0.2	0.2	-0.5
High cholesterol (Self-reported)	0.2	0.3	1.3	-0.2	-0.2	-0.5	-0.3	0.1	-0.9	-1.1
Medication: Bendroflumethiazide	2.1	3.2	6.7	2.2	1.3	1.6	1.5	1.6	-2.6	-1.3
Medication: Paracetamol	0.3	0.4	1.1	-0.1	0.2	1.0	0.5	0.5	-0.6	-0.9
Medication: Lisinopril	0.3	0.4	1.3	-0.1	-0.7	0.0	-0.8	-1.2	0.4	0.6
Medication: Atorvastatin	0.2	0.2	0.6	0.8	-0.3	0.4	-0.5	-0.4	-0.2	-0.6
Illnesses of father: High blood pressure	0.9	1.2	3.2	0.6	0.8	0.7	0.7	1.3	-1.8	-1.1
Alcohol drinker status: Never	1.0	1.2	3.2	-0.1	0.3	-1.0	-0.0	0.8	-1.8	-1.7
Ever smoked	0.3	0.5	1.2	-1.1	-1.1	-0.2	-1.0	-0.4	0.4	-0.4
Basal metabolic rate	0.1	0.4	1.5	0.0	-0.2	-0.4	-0.3	-0.1	-1.2	-1.0
Leg fat percentage (left)	0.3	1.1	3.2	-0.5	-0.4	-1.0	-0.7	0.3	-1.8	-1.6
Arm fat-free mass (left)	0.1	0.3	1.7	0.1	0.1	0.0	0.0	0.2	-1.3	-0.7
Number of operations (self-reported)	0.8	1.2	2.1	-0.3	0.7	1.2	1.3	1.2	-1.5	-1.0
Average weekly beer plus cider intake	0.3	0.5	1.1	-1.0	-0.7	-0.7	-0.6	-0.5	0.4	0.6
Irritability	0.3	0.5	0.9	-1.0	-0.7	-0.4	-0.9	-0.7	0.8	0.5
Risk taking	0.5	0.7	1.4	-1.2	-0.9	-0.9	-0.9	-0.7	-0.4	-0.6
Ever had prostate specific antigen (PSA) test	0.6	0.6	2.5	-0.2	-0.3	0.4	-0.0	-0.7	1.6	1.1
Fractured/broken bones in last 5 years	0.4	0.6	1.2	-0.4	-0.7	-0.2	-0.6	-1.0	1.1	0.8
Age started oral contraceptive pill	1.5	1.9	2.7	0.8	1.5	1.6	1.6	1.6	-1.5	-0.7
Diastolic blood pressure, automated reading	0.4	1.2	3.6	0.2	0.7	-0.3	0.5	1.0	-1.9	-1.8
Ever depressed for a whole week	0.7	0.9	2.7	-1.1	-1.0	-0.6	-0.9	0.2	-0.5	-1.6
Unable to work because of sickness or disability	0.4	0.5	1.5	-0.7	-0.3	-0.8	0.0	-0.6	0.7	1.2
Commuting to job workplace: Cycle	0.5	0.6	1.7	0.7	1.0	0.5	1.0	0.3	0.1	1.3
Myopia	0.6	0.8	2.3	1.3	0.4	0.6	0.4	0.6	-0.9	-1.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.8	-0.6	-0.7	-0.8	-0.5	-1.0	1.9	1.5
Cholesterol lowering medication	0.2	0.3	0.9	-0.6	-0.2	-0.5	-0.1	0.3	-0.8	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.0	1.0	1.3	1.5	1.7	1.0	0.5	0.8
Pain experienced in last month	0.3	0.5	1.8	-0.1	-0.0	0.5	-0.2	-0.7	1.4	0.8
Supplements: Calcium	0.3	0.3	0.9	0.3	0.5	0.7	1.0	0.6	0.2	0.1
Basal cell carcinoma (self-reported)	1.0	1.2	1.9	1.1	1.4	1.2	1.3	1.3	-0.3	-0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	4.6	0.1	0.2	-0.2	-0.2	0.5	-2.1	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.0	0.7	1.3	1.0	1.7	1.5	-0.1	-0.2
Heart disease (siblings)	0.1	0.1	0.3	-0.3	-0.3	-0.1	-0.1	-0.1	-0.5	-0.5
Alcohol drinker status: Previous	0.3	0.3	1.0	0.5	0.4	1.0	0.3	0.5	-0.6	-0.3
Pack years of smoking	0.7	1.1	4.3	0.0	-0.4	-0.1	0.4	1.0	-1.4	-2.1
Impedance of whole body	0.2	1.2	4.0	0.7	0.9	0.7	1.0	0.1	1.4	2.0
Leg fat mass (left)	0.3	1.0	3.2	-0.2	-0.3	-0.8	-0.6	0.2	-1.8	-1.6
Arm predicted mass (left)	0.1	0.7	3.0	0.4	0.5	0.3	0.4	0.6	-1.7	-1.0