Hub : Genes

MFSD9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Spleen 0.3340 0.1160 3.4e-03 0.163 NA 0.074 NA 0.078 5.8e-05 NA 6.1e-03 NA 4.8e-03
2 GTEx Whole Blood 0.3990 0.0480 0.0e+00 0.499 NA 0.491 NA 0.501 2.3e-52 NA 3.0e-51 NA 1.1e-52
3 METSIM Adipose 0.0980 0.0273 3.2e-10 0.049 0.076 0.070 0.074 0.076 6.5e-08 1.6e-11 1.2e-10 3.6e-11 1.9e-11
4 NTR Blood 0.0514 0.0148 9.2e-11 0.055 0.029 0.040 0.044 0.045 2.8e-17 1.2e-09 6.6e-13 3.8e-14 1.7e-14
5 YFS Blood 0.0940 0.0217 1.1e-16 0.030 0.056 0.072 0.072 0.070 4.0e-10 6.9e-18 1.5e-22 1.4e-22 7.7e-22
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0773 0.0366 3.6e-04 0.024 0.039 0.034 NA 0.038 8.2e-04 3.3e-05 9.1e-05 NA 4.2e-05
7 TCGA Brain Lower Grade Glioma 0.0719 0.0324 6.7e-04 0.039 0.039 0.043 NA 0.049 2.7e-05 2.5e-05 1.2e-05 NA 3.0e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.3 0.5 1.3 0.4 -0.5 -1.1 -1.0 -0.6 0.6 -0.4
Bipolar Disorder or Schizophrenia 1.2 2.9 6.7 -0.8 -2.0 -1.7 -2.6 -1.9 1.8 -0.1
Depressed Affect (Nagel 2018) 1.0 2.1 4.5 -2.1 -1.5 -0.9 -1.3 -1.7 1.0 1.1
Depression (Nagel 2018) 0.1 0.2 0.4 -0.4 -0.5 0.1 0.0 -0.6 0.6 0.6
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.6 -0.1 0.0 0.9 1.3 0.4 0.4 -0.1
Neuroticism (Nagel 2018) 1.3 3.0 4.6 -2.1 -2.1 -1.0 -1.3 -2.1 1.8 1.3
Schizophrenia (2018) 1.5 3.1 6.2 -1.4 -2.2 -1.2 -2.5 -1.9 1.8 0.2
Schizophrenia vs Biploar Disorder 0.2 0.3 1.3 -1.1 -0.2 -0.5 0.2 0.0 -0.6 0.2
Worry (Nagel 2018) 0.9 1.9 3.3 -0.7 -1.5 -1.1 -0.8 -1.8 1.8 1.5
Alzheimer’s Disease (in mother) 0.4 0.4 0.8 -0.6 -0.7 -0.4 -0.9 -0.4 0.7 -0.8
Alzheimer’s Disease (in father) 0.7 0.8 1.4 -1.0 -1.2 -0.8 -1.0 -1.0 0.8 0.0
Alzheimer’s Disease (including proxy) 0.9 1.3 2.2 -1.0 -1.5 -1.1 -1.4 -1.0 0.8 -1.0
Crohns Disease (2017) 0.3 0.8 1.8 0.5 0.4 -0.4 1.4 0.9 -1.2 -0.6
Irritable Bowel Disease (IBD) 0.3 0.8 2.4 -0.1 0.2 -0.4 0.9 1.0 -1.6 -1.0
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.6 -0.4 -0.2 -0.2 0.2 -0.5 -0.5
Major Depression (MDD) 0.5 0.5 1.9 -0.5 0.1 1.1 0.2 0.0 1.4 0.6
Reaction Time 0.1 0.2 0.6 -0.8 -0.5 -0.7 -0.3 -0.3 0.2 0.1
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.3 -0.4 0.2 -0.4 0.4 0.4 0.5 0.3
Breast Cancer 0.4 0.9 2.0 0.8 1.1 0.6 1.4 1.4 -0.5 -0.3
Ovarian Cancer 0.1 0.2 0.6 -0.7 -0.3 0.1 0.8 -0.0 -0.1 0.0
Prostate Cancer 0.8 1.1 3.4 1.9 1.4 0.8 0.5 0.9 -0.6 0.3
Age at First Birth 0.2 0.3 1.3 -0.3 -0.5 0.6 -0.3 -0.1 -0.6 -1.1
Bipolar Disorder (2011) 2.9 2.8 5.4 -1.3 -2.3 -1.9 -2.1 -1.8 1.1 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 1.0 0.7 0.9 1.0 1.0 0.5 -1.0 0.1
Coronary Artery Disease (CAD) 1.2 1.4 2.1 -1.3 -1.5 -1.4 -1.3 -1.4 0.6 -0.4
Crohns Disease (2012) 0.2 0.3 1.2 0.6 0.3 -0.4 0.3 0.6 -1.1 -0.5
Mean Putamen Volume 1.3 1.5 2.4 -1.5 -1.5 -1.2 -1.4 -1.4 0.9 0.2
Fasting Glucose 1.3 1.6 2.3 1.5 1.2 1.2 0.9 1.3 -1.5 -1.0
HbA1C 0.7 0.8 2.1 0.2 0.8 1.1 0.7 0.7 -1.5 -0.4
HDL Cholesterol 0.9 1.5 4.5 -0.1 0.0 0.8 0.6 1.2 -1.8 -2.1
LDL Cholesterol 0.6 1.0 1.5 0.8 1.0 1.0 1.1 1.2 -1.0 -0.5
Lupus 2.0 3.0 4.6 -1.2 -1.7 -2.0 -1.7 -2.1 2.0 0.7
Neuroticism (2016) 0.1 0.1 0.4 -0.1 -0.1 0.1 -0.3 -0.6 0.0 0.5
Primary Biliary Cirrhosis 0.0 0.1 0.2 -0.2 0.3 -0.3 -0.0 0.1 -0.4 0.1
Rheumatoid Arthritis 0.1 0.2 0.5 0.7 0.5 0.4 0.4 0.2 0.0 -0.1
Schizophrenia (2014) 1.9 4.2 10.3 -1.7 -2.7 -1.9 -3.2 -1.9 0.8 -1.1
Triglycerides 1.1 1.9 3.0 1.6 1.7 1.1 1.6 1.5 -1.2 -0.1
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.5 -0.2 -0.2 -0.5 -0.7 -0.2 -0.3 -0.5
Ulcerative Colitis 0.5 0.7 2.9 -0.6 -0.2 -0.5 -0.1 0.6 -1.7 -1.0
Blood Eosinophil Count 1.8 13.8 27.1 -3.1 -5.2 1.8 -5.2 -4.1 -2.3 -2.9
Blood Platelet Count 0.1 1.6 2.7 -0.5 0.8 1.3 1.1 1.4 -1.6 -1.6
Blood Red Count 0.3 2.8 5.1 2.2 2.2 1.0 2.3 1.7 -0.1 0.9
Blood White Count 0.6 4.3 9.9 -3.1 -2.8 -0.1 -2.4 -2.1 1.4 0.4
Heel T-Score 0.0 0.2 0.4 0.6 0.3 0.2 0.5 0.4 -0.4 -0.3
BMI 0.2 1.1 2.2 -0.8 -0.7 -1.4 -1.0 -0.2 -1.5 -1.1
Height 0.2 4.6 9.0 3.0 2.6 2.2 2.8 1.3 -0.4 1.4
Waist Hip Ratio (WHR) 0.2 0.9 4.2 0.2 0.5 0.5 0.4 0.9 -2.1 -0.9
Systolic Blood Pressure 0.3 1.3 1.9 1.4 1.1 1.2 1.0 1.1 -1.3 -0.4
Smoking Status 0.1 0.3 0.7 -0.6 -0.8 -0.1 -0.7 -0.1 0.2 -0.7
Allergy or Eczema 1.6 4.1 9.0 -2.4 -2.9 0.4 -3.0 -2.1 -0.5 -0.8
Cardiovascular Disease 0.6 1.9 4.0 1.5 1.3 2.0 1.3 1.1 -1.5 -0.7
Hypothyroidism (self reported) 0.3 0.7 1.5 -1.2 -1.0 -0.6 -1.0 -0.3 0.0 -0.9
Respiratory disease 0.9 2.0 3.5 -1.5 -1.7 1.8 -1.5 -1.9 -0.5 -0.0
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.2 0.5 0.1 -0.1 0.0 -0.2 0.1 0.2
Lung FEV1/FVC ratio 0.4 1.9 7.7 -0.0 -1.2 -2.8 -1.2 -0.6 1.6 -0.0
Lung FVC 0.1 0.4 1.1 -0.3 -0.6 -0.6 -1.0 -0.5 -0.4 -0.8
Neuroticism 0.8 2.0 3.2 -1.8 -1.6 -0.9 -1.6 -1.5 1.2 1.1
Chronotype (morning person) 0.9 2.0 4.9 1.4 2.2 0.4 1.8 1.2 -1.4 0.1
Hair Pigment 0.1 1.6 3.7 1.1 1.9 0.5 1.6 1.3 -0.9 0.7
Tanning 0.1 1.4 2.4 -1.4 -1.5 -0.8 -1.5 -1.5 0.4 -0.4
Hand grip strength (left) 0.7 1.8 2.8 -1.5 -1.7 -1.7 -1.7 -0.8 -0.5 -1.0
Number of treatments/medications taken 0.5 0.8 2.4 -0.8 0.0 1.3 0.6 0.3 -1.6 -0.8
Average weekly spirits intake 3.7 4.6 8.7 1.8 1.6 3.0 1.7 2.1 -2.6 -1.7
Sensitivity / hurt feelings 0.1 0.2 0.5 -0.2 -0.6 0.3 -0.7 -0.6 0.5 0.3
Frequency of depressed mood in last 2 weeks 1.8 2.5 5.3 1.8 1.5 2.3 1.8 1.4 -1.0 0.4
Hearing difficulty/problems: Yes 1.0 1.5 2.7 0.7 1.1 1.7 1.0 1.5 -1.6 -0.8
Relative age of first facial hair 1.2 2.5 4.5 -1.7 -1.8 -0.8 -1.9 -1.5 2.1 0.6
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 1.0 -1.0 0.0 0.0 0.3 0.3 -0.3 0.1
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.2 0.2 1.0 0.2 1.5 0.7 -0.7 0.2
Ever had hysterectomy (womb removed) 3.5 4.0 7.2 1.2 2.0 2.7 2.4 2.3 -1.7 -1.1
Systolic blood pressure, automated reading 0.2 0.6 1.5 0.5 0.5 0.2 0.2 0.8 -1.2 -1.2
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.9 -1.4 -0.9 -0.4 -0.9 -0.4 0.7 -0.1
Angina 0.4 0.6 2.5 -0.3 -0.0 0.6 -0.0 0.3 -1.6 -1.0
Medication for hormone replacement therapy 1.8 2.0 3.5 1.4 1.2 1.4 1.9 1.7 -0.8 -1.2
Vitamin and mineral supplements 0.5 0.7 1.3 1.1 -0.1 -0.4 -0.6 -0.9 1.1 1.1
Supplements: Zinc 0.5 0.5 2.0 -0.1 0.1 1.4 0.7 0.8 -0.4 -0.6
Medication: Co-codamol 0.4 0.4 1.8 -0.8 0.3 0.2 0.4 0.3 -1.3 -0.3
Medication: Metformin 0.2 0.2 0.6 0.8 0.6 0.2 0.4 0.2 0.4 0.5
Diabetes (father) 0.7 0.9 4.8 -0.2 0.1 -0.2 0.6 -0.0 2.2 1.1
Diabetes (mother) 3.1 3.9 6.3 2.5 2.1 2.2 2.2 2.2 -1.6 -0.4
Severe depression (siblings) 1.0 1.1 1.7 -1.2 -1.0 -1.2 -1.3 -0.9 1.2 -0.0
Pack years adult smoking proportion 0.4 0.6 2.5 -0.1 -0.6 -0.3 0.1 0.5 -0.9 -1.6
Impedance of leg (right) 0.3 1.4 5.2 0.3 0.9 1.0 1.1 0.1 1.3 2.3
Leg fat-free mass (left) 0.1 0.6 1.9 0.0 -0.4 -0.6 -0.5 -0.1 -1.4 -1.4
Trunk fat percentage 0.3 1.3 2.6 -0.6 -0.6 -1.5 -1.0 -0.0 -1.6 -1.6
Hand grip strength (right) 0.5 1.4 2.5 -1.5 -1.5 -1.2 -1.6 -0.9 0.1 -0.8
Townsend deprivation index at recruitment 1.3 1.8 3.5 -1.2 -1.7 -1.0 -1.9 -1.7 0.9 0.5
Current tobacco smoking 0.2 0.4 0.8 -0.9 -0.6 -0.3 -0.5 -0.3 0.8 0.6
Average weekly fortified wine intake 1.2 1.5 2.9 0.7 1.0 1.6 1.3 1.7 -1.0 -0.7
Maternal smoking around birth 0.7 1.0 2.3 -1.0 -0.9 -1.5 -0.6 -1.4 0.1 0.8
Fed-up feelings 0.7 1.3 2.2 -1.5 -1.0 -0.3 -1.2 -1.2 1.3 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 1.8 -1.3 -1.4 -0.9 -1.3 -1.3 0.6 0.8
Relative age voice broke 1.3 1.9 5.0 -1.1 -0.5 -1.2 -0.7 -1.3 1.8 2.2
Taking other prescription medications 0.4 0.6 2.6 -1.6 -0.5 1.1 0.1 -0.4 0.2 0.1
Age when periods started (menarche) 1.1 2.6 4.2 1.8 1.9 1.6 2.1 0.8 0.6 2.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 1.2 0.6 0.5 1.1 0.7 0.3 0.8 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.8 5.8 1.7 1.1 1.4 1.1 1.7 -2.0 -2.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.9 1.4 0.8 0.3 0.4 0.6 0.1 0.2
Qualifications: CSEs or equivalent 0.8 1.1 2.2 -0.1 -1.3 -1.1 -1.2 -1.5 0.9 0.4
Serious illness, injury or assault to yourself 0.1 0.2 0.4 -0.0 0.3 0.6 0.6 0.2 -0.5 0.1
High blood pressure 0.2 0.7 2.1 0.5 0.4 0.6 0.3 0.5 -1.4 -1.1
Hayfever, allergic rhinitis or eczema 1.1 2.5 4.8 -2.1 -2.2 0.7 -2.2 -1.6 -0.2 -0.5
Multivitamins +/- minerals 1.0 1.3 2.9 -0.3 0.6 0.9 0.9 1.1 -1.7 -1.6
Stomach or abdominal pain in last month 3.2 4.0 6.8 -2.1 -2.6 -1.2 -2.2 -2.4 2.1 0.7
Supplements: Glucosamine 0.4 0.5 1.2 -1.1 -0.5 -0.6 0.1 0.2 -1.1 -0.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.2 0.0 0.2 0.3 0.4 -0.0 -0.2 1.1
Medication: Atenolol 0.6 0.7 2.3 1.5 0.9 0.3 0.8 0.0 -0.5 1.0
Medication: Levothyroxine sodium 0.3 0.5 1.3 -0.6 -1.1 -0.1 -1.1 -0.5 0.5 -0.6
Sitting height 0.2 1.2 3.0 1.7 1.3 1.2 1.2 0.6 -0.5 0.4
Chronic bronchitis/emphysema (father) 2.9 3.4 6.7 2.6 2.0 2.5 1.9 1.3 -0.8 0.8
High blood pressure (mother) 0.2 0.3 1.1 0.4 -0.1 0.6 -0.1 0.5 -0.2 -1.1
Body mass index (BMI) 0.5 2.3 5.8 -1.0 -1.1 -1.6 -1.5 -0.2 -1.9 -2.4
Impedance of leg (left) 0.3 1.4 4.7 0.4 0.9 1.1 1.2 0.2 1.3 2.2
Leg predicted mass (left) 0.1 0.6 1.8 0.0 -0.4 -0.6 -0.6 -0.1 -1.4 -1.3
Trunk fat mass 0.2 1.0 2.8 -0.3 -0.4 -1.2 -0.8 0.0 -1.7 -1.5
Waist circumference 0.4 1.3 4.9 -0.2 0.1 -0.6 -0.1 0.7 -2.2 -1.9
Number of incorrect matches in round 4.5 7.4 13.2 -2.8 -2.9 -3.6 -3.0 -2.9 2.0 0.9
Past tobacco smoking 0.2 0.4 1.7 0.7 0.5 -0.3 0.2 -0.4 0.5 1.3
Alcohol usually taken with meals 1.1 1.8 5.6 -0.8 0.1 -0.5 0.2 1.4 -2.4 -2.1
Nervous feelings 0.3 0.5 1.6 0.5 0.2 0.9 0.7 0.1 0.6 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 1.2 0.1 0.1 0.7 0.0 -0.5 0.2 1.1
Hearing difficulty/problems with background noise 2.3 3.7 7.0 1.6 1.8 2.6 2.2 2.3 -1.5 -0.8
Hair/balding pattern: Pattern 2 1.2 1.5 3.7 -1.1 -1.2 -1.9 -1.2 -0.4 -1.0 -1.3
Had menopause 4.8 5.9 10.0 2.2 3.0 2.3 3.2 2.7 -2.2 -0.1
Had other major operations 1.8 2.2 3.2 1.4 1.5 1.6 1.8 1.8 -1.2 -1.1
Forced vital capacity (FVC) 0.1 0.4 0.8 -0.0 -0.3 -0.4 -0.3 -0.9 0.7 0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 3.2 0.2 0.4 0.2 0.4 0.9 -0.8 -1.8
Ever unenthusiastic/disinterested for a whole week 2.8 3.4 6.4 -1.9 -2.3 -1.9 -2.5 -1.3 0.4 -1.8
Qualifications: None of the above 0.6 1.4 2.3 1.0 1.5 1.4 1.3 1.3 -0.9 0.3
Financial difficulties in last 2 years 0.6 0.8 1.9 -1.4 -1.0 -0.3 -0.9 -0.9 0.3 0.9
Mouth/teeth dental problems 0.2 0.2 0.9 -0.2 -0.2 -0.5 -0.4 -0.5 1.0 0.3
Heart attack 0.8 1.0 5.0 -0.0 0.0 -0.5 -0.3 0.3 -2.2 -1.4
Allergy 1.8 4.2 8.2 2.7 2.9 -1.1 2.6 2.4 -0.3 0.0
Pain all over the body in last month 0.2 0.2 0.7 0.2 0.1 -0.2 0.0 0.4 -0.8 -0.4
Diabetes (self-reported) 0.1 0.1 0.3 -0.3 -0.3 0.1 -0.3 0.1 0.5 -0.5
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.1 0.5 0.6 1.4 0.6 0.3 -1.0 -0.2
Medication: Ramipril 0.2 0.2 0.6 -0.4 -0.4 -0.5 -0.7 -0.2 -0.3 -0.4
Medication: Simvastatin 0.3 0.4 1.2 -1.1 -0.6 -0.5 -0.8 -0.2 -0.1 -0.7
Fluid intelligence score 0.2 0.4 1.6 -0.8 -0.7 -0.2 -0.4 -0.1 1.2 -0.2
Illnesses of siblings 0.1 0.1 0.4 -0.3 -0.1 -0.7 -0.0 -0.1 0.0 0.6
Neuroticism score 0.6 1.3 2.2 -1.3 -1.1 -0.5 -1.1 -1.3 0.8 1.5
Weight 0.2 1.0 2.9 -0.2 -0.3 -0.8 -0.6 0.1 -1.7 -1.7
Impedance of arm (right) 0.2 0.8 2.7 0.3 0.3 0.1 0.4 -0.4 1.5 1.6
Arm fat percentage (right) 0.7 2.6 5.7 -1.1 -1.4 -1.9 -1.8 -0.4 -1.6 -2.4
Trunk fat-free mass 0.0 0.2 0.8 0.1 -0.0 -0.1 0.0 -0.1 -0.9 -0.5
Hip circumference 0.2 0.8 3.2 0.2 0.2 -0.4 -0.1 0.6 -1.4 -1.8
Time employed in main current job 0.5 0.6 1.7 -0.8 -0.0 -0.7 0.1 -0.6 1.1 1.3
Alcohol intake versus 10 years previously 1.0 1.5 3.5 -0.6 -0.7 -0.7 -0.7 -1.6 1.7 1.9
Father’s age at death 0.4 0.5 1.7 -0.1 0.2 0.3 0.4 0.1 1.3 1.1
Worrier / anxious feelings 0.5 0.9 3.3 0.3 0.1 1.0 0.5 -0.3 1.3 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.2 -0.2 0.0 0.1 -0.1 -0.3 -0.4 0.3
Falls in the last year 0.3 0.4 0.8 0.0 0.7 0.4 0.9 0.6 -0.8 0.4
Hair/balding pattern: Pattern 3 1.4 2.1 4.4 2.1 1.4 2.0 1.3 1.3 -0.6 0.1
Number of live births 3.5 5.0 6.8 2.6 2.4 2.5 2.3 2.5 -1.4 -1.5
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.9 0.6 0.0 -0.7 -0.2 -0.7 0.9 0.9
Pulse rate 0.5 0.8 1.7 -0.4 -0.7 -0.7 -0.8 -1.3 1.0 1.1
Happiness 0.5 0.7 1.3 -1.1 -0.8 -0.9 -1.0 -0.4 -0.0 -0.8
Noisy workplace 0.1 0.1 0.3 -0.0 -0.1 0.2 -0.2 -0.5 -0.4 0.6
Qualifications: A levels/AS levels or equivalent 0.6 1.3 3.3 -1.0 -1.0 -1.8 -1.1 -0.7 -0.5 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.6 -0.3 -0.6 -0.4 -0.5 0.1 0.7 -1.3
Mouth/teeth dental problems: Dentures 0.1 0.2 0.7 0.2 0.5 0.8 0.5 0.3 -0.6 0.2
Asthma 1.1 2.2 2.9 -0.9 -1.7 1.7 -1.6 -1.3 -1.6 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.2 0.5 -0.2 0.1 0.5 0.6 -0.1 0.3 0.7
Medication: Cholesterol lowering 0.2 0.3 0.9 -0.3 -0.5 -0.4 -0.7 -0.3 -0.5 -0.9
Depression (self-reported) 0.3 0.3 1.0 -1.0 -0.7 -0.5 -0.5 -0.4 0.5 -0.0
Medication: Lansoprazole 0.6 0.7 2.1 0.5 0.4 1.4 0.8 1.0 -0.7 -0.5
Prospective memory result 0.8 1.0 2.7 -0.1 -0.6 -0.1 -0.9 -1.2 1.6 1.2
Lung cancer (father) 0.5 0.6 2.2 -1.5 -0.6 -0.3 -0.8 -0.3 0.7 -0.3
Illnesses of mother 1.4 1.8 5.6 -1.0 -0.6 -0.8 -0.6 -1.6 1.4 2.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 1.5 0.3 -0.2 -0.7 -0.4 -0.9 0.9 1.2
Pulse wave Arterial Stiffness index 2.5 2.9 5.5 2.3 2.3 1.3 2.1 1.4 -0.8 0.8
Impedance of arm (left) 0.2 0.7 2.2 0.4 0.5 0.3 0.6 -0.3 1.4 1.5
Arm fat mass (right) 0.4 1.6 3.8 -0.8 -0.9 -1.5 -1.2 -0.2 -1.6 -1.9
Trunk predicted mass 0.0 0.2 1.1 0.2 0.1 0.0 0.1 0.1 -1.1 -0.7
Standing height 0.2 1.5 2.7 1.5 1.4 1.4 1.6 0.5 0.3 1.2
Length of working week for main job 2.2 2.4 3.9 -1.4 -1.2 -1.6 -1.2 -1.9 2.0 1.5
Exposure to tobacco smoke at home 1.9 2.1 5.2 1.3 1.5 1.8 2.3 1.6 -0.0 0.2
Breastfed as a baby 0.4 0.5 1.4 -1.0 -0.5 -1.2 -0.4 0.1 -0.3 -0.7
Tense / ‘highly strung’ 0.2 0.3 0.8 -0.3 -0.7 -0.9 -0.5 -0.4 -0.3 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.9 0.4 0.0 1.1 0.4 0.9 -0.8 -1.4
Hair/balding pattern: Pattern 4 0.2 0.4 1.6 -0.3 -0.1 -0.3 -0.0 -0.6 0.9 1.3
Birth weight of first child 0.5 0.9 2.1 -0.2 -0.7 -1.0 -0.7 -1.5 1.1 1.1
Peak expiratory flow (PEF) 0.4 1.0 1.9 -0.4 -0.7 -1.3 -0.8 -1.2 1.4 0.9
Pulse wave reflection index 0.9 1.2 1.8 0.9 1.0 0.5 1.2 1.4 -1.3 -0.9
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.7 -1.9 -1.1 -1.2 -1.1 -0.4 -0.7 -1.2
Loud music exposure frequency 2.0 2.2 4.2 2.0 1.5 1.5 1.4 1.4 -1.1 -1.2
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 4.2 -1.4 -1.5 -2.1 -1.9 -1.6 0.4 -0.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.1 0.4 -0.1 -0.6 0.1 -0.5 -0.2 0.0 -0.3
Blood clot in the leg (DVT) 0.5 0.6 1.9 0.5 1.0 0.5 1.4 1.1 0.1 0.0
Medication: Paracetamol 0.2 0.3 1.5 -0.2 0.2 1.2 0.5 0.2 -0.3 -0.3
Headache pain in last month 0.1 0.2 0.8 0.3 0.2 0.5 0.3 0.4 -0.9 -0.1
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 3.2 0.3 0.4 0.1 0.6 0.0 1.8 1.5
Glaucoma (self-reported) 0.7 0.8 3.9 -1.0 -0.4 -0.2 -0.4 0.4 -2.0 -0.7
Gout (self-reported) 0.6 0.8 1.3 1.1 0.7 0.7 0.8 1.0 -0.7 -1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.6 -1.2 -1.1 -0.3 -1.1 -0.6 0.3 -0.6
Medication: Amlodipine 0.7 0.9 1.9 0.6 0.7 0.7 0.8 1.1 -1.2 -1.4
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.4 -0.9 -1.1 0.2 -1.0 -1.2 -0.6 -0.4
Birth weight 0.2 0.5 1.4 1.2 0.4 0.7 0.4 -0.0 0.9 0.5
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.3 -1.1 -0.7 -0.9 -0.4 -0.7 -0.5 -0.9
High blood pressure (siblings) 0.3 0.5 0.8 0.6 0.6 0.5 0.7 0.7 -0.9 -0.8
Forced vital capacity (FVC), Best measure 0.1 0.4 1.1 -0.0 -0.3 -0.1 -0.4 -1.0 0.8 1.1
Body fat percentage 0.4 1.6 3.4 -0.7 -0.8 -1.5 -1.1 -0.0 -1.7 -1.9
Leg fat percentage (right) 0.3 1.2 3.4 -0.5 -0.4 -1.1 -0.8 0.2 -1.9 -1.6
Arm fat-free mass (right) 0.1 0.6 2.6 0.4 0.4 0.2 0.4 0.5 -1.6 -0.9
Exposure to tobacco smoke outside home 0.7 0.9 2.7 -1.1 -0.8 -1.6 -0.7 -0.6 -0.5 -0.7
Comparative body size at age 10 0.6 1.6 3.3 -1.2 -1.4 -1.8 -1.5 -0.9 -0.6 -0.9
Number of full brothers 0.3 0.4 1.1 -0.7 -0.5 0.3 -0.5 -0.6 1.1 0.2
Worry too long after embarrassment 0.2 0.3 0.8 -0.6 -0.6 -0.4 -0.3 -0.5 0.0 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 3.2 -0.3 -1.1 0.2 -0.4 0.3 0.1 -1.8
Wheeze or whistling in the chest in last year 1.4 2.5 4.8 -2.1 -2.1 0.2 -2.0 -2.2 0.0 0.1
Number of children fathered 1.2 1.4 4.7 0.3 -0.0 -0.1 -0.4 0.7 -2.2 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.8 0.5 0.7 0.9 0.8 0.9 -1.4 -0.3
Age at first live birth 0.4 0.7 1.3 -0.8 -1.1 -0.7 -1.1 -0.8 0.8 0.1
Pulse wave peak to peak time 1.9 2.2 4.1 -2.0 -2.0 -1.1 -1.8 -1.2 0.9 -0.7
Health satisfaction 0.2 0.3 0.8 -0.5 -0.4 0.0 -0.5 -0.5 -0.9 -0.7
Shortness of breath walking on level ground 0.4 0.5 1.3 -0.0 0.5 0.8 0.4 0.7 -1.1 -0.7
Qualifications: College or University degree 0.4 1.4 5.3 0.5 0.2 1.1 0.3 1.4 -1.1 -2.3
Eye problems/disorders: None of the above 0.3 0.3 0.7 0.6 -0.4 -0.5 -0.5 -0.7 0.9 0.1
Mouth/teeth dental problems: Loose teeth 4.3 5.1 8.0 -2.5 -2.6 -2.8 -2.5 -2.4 1.6 -0.0
Emphysema/chronic bronchitis 2.4 2.7 4.2 -1.9 -1.6 -0.4 -1.4 -2.0 1.8 1.7
Medication for pain relief, constipation, heartburn 0.1 0.2 0.9 1.0 0.2 -0.2 -0.2 0.1 0.3 -0.2
Neck or shoulder pain in last month 0.3 0.4 0.7 0.6 0.5 0.6 0.4 0.5 -0.7 -0.8
Medication: Blood pressure 0.6 1.0 4.9 0.3 0.0 0.3 -0.0 0.3 -2.2 -1.3
Angina (self-reported) 0.3 0.4 2.0 -0.3 -0.1 0.4 -0.2 0.0 -1.4 -0.7
Migraine (self-reported) 2.7 3.4 5.2 1.8 2.0 2.3 2.2 1.7 -1.8 -0.3
Medication: Ibuprofen 0.4 0.5 1.4 0.0 0.6 0.9 1.2 0.7 -0.3 0.6
Medication: Allopurinol 0.3 0.4 1.1 -0.6 -0.9 -0.3 -0.7 -0.2 0.5 -1.1
Medication: Omeprazole 0.6 0.7 1.2 0.3 0.9 1.0 1.1 0.5 0.9 1.0
Medication: Seretide 50 evohaler 0.3 0.3 0.7 -0.3 -0.5 0.8 -0.7 -0.4 -0.6 -0.4
Mean time to correctly identify matches 0.1 0.1 0.4 -0.7 -0.0 -0.6 0.2 0.2 0.2 0.0
Heart disease (mother) 1.5 1.8 7.9 -0.3 -0.2 -0.9 -0.2 1.2 -1.6 -2.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.5 0.2 0.6 0.1 0.7 0.2 0.6 0.7
Whole body fat mass 0.3 1.1 2.7 -0.4 -0.6 -1.0 -0.9 0.0 -1.6 -1.6
Leg fat mass (right) 0.3 1.0 3.1 -0.2 -0.4 -0.9 -0.7 0.2 -1.8 -1.6
Arm predicted mass (right) 0.1 0.6 2.7 0.5 0.4 0.2 0.3 0.4 -1.6 -0.8
Pulse rate, automated reading 0.6 1.9 3.3 1.8 1.8 1.2 1.5 1.2 -1.4 -0.4
Alcohol intake frequency. 0.2 0.5 1.8 -0.2 -0.2 -0.8 -0.2 -0.7 0.8 1.4
Comparative height size at age 10 0.0 0.2 0.5 -0.1 -0.3 -0.2 0.0 -0.3 -0.7 -0.7
Number of full sisters 0.4 0.4 0.8 0.7 0.5 0.4 0.8 -0.3 0.8 0.9
Suffer from ‘nerves’ 0.5 0.8 1.9 -0.6 -0.9 -1.4 -0.9 -1.3 -0.0 0.5
Overall health rating 0.8 1.7 2.6 -1.5 -1.0 -1.2 -0.9 -1.5 1.3 1.6
Chest pain or discomfort 0.5 0.8 2.6 -0.4 0.5 1.6 0.6 -0.2 0.4 1.3
Had major operations 0.3 0.3 0.8 -0.3 0.1 0.9 0.4 0.5 -0.9 -0.0
Age at last live birth 0.7 1.0 2.9 -0.4 -1.1 -0.2 -1.1 -1.1 1.7 0.4
Family relationship satisfaction 1.1 1.3 2.8 -1.0 -1.3 -1.2 -1.7 -1.0 0.7 -1.1
Leg pain on walking 0.4 0.5 1.0 -0.7 -0.6 -0.6 -0.5 -0.9 1.0 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.4 -0.6 -1.2 -0.5 -1.1 -0.8 -0.3 -0.5
Commuting to job workplace: Car/motor vehicle 2.1 2.4 5.2 1.6 1.8 2.3 1.6 1.4 -1.1 0.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.4 0.6 0.5 0.5 0.3 0.3 0.1 0.3
Medication: Aspirin 1.4 1.8 6.8 -0.3 -0.2 -0.3 -0.2 0.9 -2.6 -2.2
Supplements: Vitamin C 1.2 1.4 3.2 -1.8 -1.1 -1.0 -1.1 -1.3 0.8 1.1
Knee pain experienced in last month 1.2 1.9 5.0 0.8 1.3 0.4 1.4 1.6 -2.2 -1.1
Hypertension (Self-reported) 0.4 1.2 2.6 1.0 0.8 1.2 0.8 0.9 -1.6 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.2 -0.2 -0.4 0.1 -0.2 -0.3 0.4 0.3
Illnesses of father: Heart disease 0.6 0.8 2.4 0.6 1.1 0.1 1.2 0.2 0.0 1.5
Illnesses of siblings: Diabetes 1.6 1.9 3.5 -1.4 -1.5 -1.9 -1.7 -1.3 1.1 -0.3
Smoking status: Previous 0.5 0.7 2.8 0.2 0.0 0.5 0.3 0.8 -1.1 -1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 1.2 0.2 0.2 0.2 0.4 -0.6 0.3 1.1
Whole body fat-free mass 0.1 0.4 1.5 0.1 -0.1 -0.2 -0.2 0.0 -1.2 -1.0
Leg fat-free mass (right) 0.1 0.5 1.5 0.1 -0.4 -0.7 -0.6 -0.2 -1.1 -1.2
Arm fat percentage (left) 0.6 2.5 5.5 -1.0 -1.3 -1.9 -1.7 -0.4 -1.7 -2.4
Average weekly red wine intake 1.6 2.4 4.9 -2.2 -1.7 -1.2 -1.6 -0.5 -0.4 -2.0
Handedness (chirality/laterality): Left-handed 2.2 2.6 4.1 -0.8 -1.7 -0.7 -1.8 -1.9 2.0 1.8
Mood swings 1.5 2.6 5.1 -2.3 -1.5 -1.3 -1.6 -1.7 0.9 1.7
Loneliness, isolation 0.1 0.2 0.5 -0.2 -0.3 0.7 -0.4 -0.2 -0.4 -0.3
Long-standing illness, disability or infirmity 0.4 0.5 1.7 -0.6 0.0 1.3 0.3 0.7 -0.2 -1.1
Ever had bowel cancer screening 0.6 0.7 1.3 0.9 1.1 0.2 1.2 1.1 -0.1 -0.4
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.3 0.4 0.4 0.2 0.6 -0.1 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 1.4 -1.2 -1.1 -0.3 -0.8 -1.0 1.1 0.4
Friendships satisfaction 0.2 0.3 0.6 0.4 -0.4 -0.7 -0.8 -0.6 0.6 0.1
Qualifications: nursing, teaching 2.4 3.7 7.7 -2.1 -2.2 -2.8 -2.2 -1.5 1.0 -0.9
Commuting to job workplace: Walk 0.2 0.3 0.4 -0.5 -0.6 -0.6 -0.5 -0.3 -0.4 -0.6
Eye problems/disorders: Cataract 0.6 0.7 1.6 0.1 0.7 0.1 1.0 1.2 -0.8 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.7 1.0 1.7 -1.3 -1.1 -1.3 -0.9 -1.1 0.7 0.6
Medication for cholesterol 0.5 0.8 1.8 -0.7 -0.7 -0.5 -0.7 -0.9 1.0 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.7 -0.9 -1.3 -0.5 -0.6 -0.8 0.2 -0.6
Back pain experienced in last month 0.0 0.1 0.2 -0.4 -0.2 -0.3 -0.1 0.0 -0.4 -0.1
Mineral and other dietary supplements 0.2 0.3 0.7 0.9 0.6 0.5 0.5 0.2 0.1 0.4
Breast cancer (self-reported) 0.1 0.1 0.3 0.2 0.4 0.2 0.1 0.1 -0.5 -0.0
Asthma (self-reported) 1.2 2.3 3.7 -1.1 -1.9 1.5 -1.8 -1.5 -1.4 -1.2
Osteoporosis (self-reported) 0.1 0.1 0.5 -0.4 0.3 0.5 0.3 -0.0 0.1 0.7
Osteoarthritis (self-reported) 1.9 2.5 5.3 0.9 1.1 1.3 1.6 2.0 -2.3 -1.4
Medication: Aspirin 0.8 1.0 3.5 -0.3 -0.4 -0.3 -0.4 0.4 -1.9 -1.7
Medication: Gliclazide 0.1 0.1 0.3 0.6 -0.1 -0.3 -0.2 -0.4 -0.3 0.1
Illnesses of father: None of the above (group 1) 0.9 1.1 3.1 -0.8 -1.2 -0.9 -1.8 -0.8 0.3 -0.9
Smoking status: Current 0.5 0.8 1.4 -1.2 -1.0 -0.5 -1.0 -0.6 1.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.5 1.2 -0.8 -1.0 -0.4 -1.1 -0.8 -0.2 0.5
Whole body water mass 0.1 0.4 1.7 0.0 -0.1 -0.2 -0.2 0.0 -1.3 -1.0
Leg predicted mass (right) 0.1 0.6 1.6 -0.0 -0.5 -0.7 -0.7 -0.2 -1.1 -1.3
Arm fat mass (left) 0.4 1.5 3.8 -0.7 -0.9 -1.4 -1.2 -0.2 -1.6 -1.9
Number of self-reported non-cancer illnesses 1.0 1.7 6.2 -2.5 -1.2 -0.5 -1.0 -0.8 -1.3 -0.7
Average weekly champagne plus white wine intake 0.2 0.3 1.1 0.7 0.5 1.1 0.3 0.1 -0.4 0.3
Miserableness 2.2 3.8 6.3 -2.5 -2.1 -1.2 -2.3 -2.2 1.6 1.4
Guilty feelings 0.7 1.1 3.2 -1.8 -1.4 -0.3 -1.1 -1.0 0.3 0.3
Wears glasses or contact lenses 1.8 2.1 4.4 1.1 1.6 1.8 1.7 2.1 -0.7 -0.4
Ever taken oral contraceptive pill 0.2 0.2 0.6 -0.6 -0.8 -0.2 -0.6 -0.4 -0.3 0.2
Hearing aid user 1.4 1.6 3.1 0.7 1.8 1.6 1.8 1.2 -0.7 0.5
Mother’s age at death 0.9 1.1 2.0 1.4 1.1 0.6 1.1 1.4 -0.6 -0.6
Financial situation satisfaction 2.5 3.1 7.4 -2.7 -2.1 -1.4 -2.0 -0.9 -0.8 -1.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.7 -0.2 0.2 0.2 -0.1 0.2 -0.8 -0.4
Commuting to job workplace: Public transport 0.2 0.3 1.5 0.1 -0.3 -0.6 -0.4 0.1 -0.2 -1.2
Eye problems/disorders: Glaucoma 0.6 0.8 3.8 -0.7 -0.1 0.2 -0.3 0.5 -1.9 -0.9
Medication: Blood pressure 0.2 0.4 0.9 1.0 0.7 0.8 0.8 0.4 0.1 -0.2
Pain type(s) experienced in last month: Hip pain 0.4 0.5 1.1 -1.0 0.4 -0.2 0.6 -0.1 0.7 1.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.9 -0.9 -0.8 -0.2 -1.0 -0.2 0.2 -0.5
High cholesterol (Self-reported) 0.2 0.3 1.3 -0.2 -0.2 -0.5 -0.3 0.1 -0.9 -1.1
Medication: Bendroflumethiazide 2.1 3.2 6.7 2.2 1.3 1.6 1.5 1.6 -2.6 -1.3
Medication: Paracetamol 0.3 0.4 1.1 -0.1 0.2 1.0 0.5 0.5 -0.6 -0.9
Medication: Lisinopril 0.3 0.4 1.3 -0.1 -0.7 0.0 -0.8 -1.2 0.4 0.6
Medication: Atorvastatin 0.2 0.2 0.6 0.8 -0.3 0.4 -0.5 -0.4 -0.2 -0.6
Illnesses of father: High blood pressure 0.9 1.2 3.2 0.6 0.8 0.7 0.7 1.3 -1.8 -1.1
Alcohol drinker status: Never 1.0 1.2 3.2 -0.1 0.3 -1.0 -0.0 0.8 -1.8 -1.7
Ever smoked 0.3 0.5 1.2 -1.1 -1.1 -0.2 -1.0 -0.4 0.4 -0.4
Basal metabolic rate 0.1 0.4 1.5 0.0 -0.2 -0.4 -0.3 -0.1 -1.2 -1.0
Leg fat percentage (left) 0.3 1.1 3.2 -0.5 -0.4 -1.0 -0.7 0.3 -1.8 -1.6
Arm fat-free mass (left) 0.1 0.3 1.7 0.1 0.1 0.0 0.0 0.2 -1.3 -0.7
Number of operations (self-reported) 0.8 1.2 2.1 -0.3 0.7 1.2 1.3 1.2 -1.5 -1.0
Average weekly beer plus cider intake 0.3 0.5 1.1 -1.0 -0.7 -0.7 -0.6 -0.5 0.4 0.6
Irritability 0.3 0.5 0.9 -1.0 -0.7 -0.4 -0.9 -0.7 0.8 0.5
Risk taking 0.5 0.7 1.4 -1.2 -0.9 -0.9 -0.9 -0.7 -0.4 -0.6
Ever had prostate specific antigen (PSA) test 0.6 0.6 2.5 -0.2 -0.3 0.4 -0.0 -0.7 1.6 1.1
Fractured/broken bones in last 5 years 0.4 0.6 1.2 -0.4 -0.7 -0.2 -0.6 -1.0 1.1 0.8
Age started oral contraceptive pill 1.5 1.9 2.7 0.8 1.5 1.6 1.6 1.6 -1.5 -0.7
Diastolic blood pressure, automated reading 0.4 1.2 3.6 0.2 0.7 -0.3 0.5 1.0 -1.9 -1.8
Ever depressed for a whole week 0.7 0.9 2.7 -1.1 -1.0 -0.6 -0.9 0.2 -0.5 -1.6
Unable to work because of sickness or disability 0.4 0.5 1.5 -0.7 -0.3 -0.8 0.0 -0.6 0.7 1.2
Commuting to job workplace: Cycle 0.5 0.6 1.7 0.7 1.0 0.5 1.0 0.3 0.1 1.3
Myopia 0.6 0.8 2.3 1.3 0.4 0.6 0.4 0.6 -0.9 -1.5
Vascular/heart problems diagnosed by doctor 0.5 1.3 3.8 -0.6 -0.7 -0.8 -0.5 -1.0 1.9 1.5
Cholesterol lowering medication 0.2 0.3 0.9 -0.6 -0.2 -0.5 -0.1 0.3 -0.8 -1.0
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 3.0 1.0 1.3 1.5 1.7 1.0 0.5 0.8
Pain experienced in last month 0.3 0.5 1.8 -0.1 -0.0 0.5 -0.2 -0.7 1.4 0.8
Supplements: Calcium 0.3 0.3 0.9 0.3 0.5 0.7 1.0 0.6 0.2 0.1
Basal cell carcinoma (self-reported) 1.0 1.2 1.9 1.1 1.4 1.2 1.3 1.3 -0.3 -0.6
Heart attack/myocardial infarction (self-reported) 0.7 0.9 4.6 0.1 0.2 -0.2 -0.2 0.5 -2.1 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 3.0 0.7 1.3 1.0 1.7 1.5 -0.1 -0.2
Heart disease (siblings) 0.1 0.1 0.3 -0.3 -0.3 -0.1 -0.1 -0.1 -0.5 -0.5
Alcohol drinker status: Previous 0.3 0.3 1.0 0.5 0.4 1.0 0.3 0.5 -0.6 -0.3
Pack years of smoking 0.7 1.1 4.3 0.0 -0.4 -0.1 0.4 1.0 -1.4 -2.1
Impedance of whole body 0.2 1.2 4.0 0.7 0.9 0.7 1.0 0.1 1.4 2.0
Leg fat mass (left) 0.3 1.0 3.2 -0.2 -0.3 -0.8 -0.6 0.2 -1.8 -1.6
Arm predicted mass (left) 0.1 0.7 3.0 0.4 0.5 0.3 0.4 0.6 -1.7 -1.0