Hub : Genes

ATG16L2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0780	0.0280	2.1e-05	0.034	0.046	0.047	0.047	0.043	5.2e-05	2.5e-06	1.7e-06	1.9e-06	5.3e-06
2	GTEx	Esophagus Mucosa	0.1310	0.0470	7.9e-04	0.013	NA	0.009	NA	0.020	4.4e-02	NA	7.9e-02	NA	1.7e-02
3	GTEx	Ovary	0.6930	0.0980	1.0e-03	-0.010	NA	0.013	NA	0.053	6.6e-01	NA	1.5e-01	NA	2.0e-02
4	GTEx	Pituitary	0.2390	0.0890	2.5e-03	0.241	NA	0.080	NA	0.154	9.8e-07	NA	4.8e-03	NA	1.1e-04
5	GTEx	Skin Sun Exposed Lower leg	0.1490	0.0570	3.6e-03	0.014	NA	0.012	NA	0.024	2.1e-02	NA	3.4e-02	NA	3.9e-03
6	YFS	Blood	0.0147	0.0069	8.1e-03	0.000	0.002	0.000	0.002	0.000	3.9e-01	6.3e-02	2.3e-01	6.3e-02	4.1e-01
7	TCGA	Colon Adenocarcinoma	0.0390	0.0230	6.5e-03	0.016	0.014	0.013	NA	0.014	3.8e-02	5.0e-02	5.4e-02	NA	4.9e-02
8	TCGA	Lung Adenocarcinoma	0.0244	0.0147	4.0e-03	0.008	0.023	0.018	NA	0.012	3.9e-02	9.8e-04	3.2e-03	NA	1.3e-02
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.0940	0.0600	4.6e-04	0.041	0.052	0.068	NA	0.045	9.2e-04	1.9e-04	2.3e-05	NA	5.1e-04
10	TCGA	Prostate Adenocarcinoma	0.0336	0.0168	7.1e-05	0.056	0.050	0.054	NA	0.052	1.4e-06	5.5e-06	2.4e-06	NA	3.8e-06
11	TCGA	Thyroid Carcinoma	0.0760	0.0310	3.3e-10	0.105	0.068	0.074	NA	0.071	2.0e-10	3.2e-07	1.1e-07	NA	2.0e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.7	2.1	0.3	-0.2	1.5	0.2	-0.2	0.7	1.2	1.3	0.3	1.0	0.8
Bipolar Disorder or Schizophrenia	0.3	0.6	1.7	-0.8	-1.3	1.0	0.1	0.0	0.3	1.1	0.7	1.3	0.4	0.1
Depressed Affect (Nagel 2018)	0.3	0.6	2.1	-0.8	0.2	1.2	0.7	0.6	-0.0	-0.6	-0.2	-0.6	-1.4	-1.0
Depression (Nagel 2018)	0.3	0.4	1.3	-0.7	-0.8	0.4	0.1	0.1	0.4	-0.5	-0.3	-0.6	-1.1	-0.8
Intelligence (Savage-Jansen 2018)	0.6	1.9	5.7	-1.0	-1.2	-2.4	-0.9	-2.1	0.0	1.5	-0.2	1.5	1.7	0.7
Neuroticism (Nagel 2018)	0.6	1.4	3.9	-0.0	0.3	1.4	-0.4	1.1	0.1	-1.8	-1.2	-0.9	-2.0	-1.4
Schizophrenia (2018)	0.3	0.6	2.3	-1.1	-1.5	0.1	0.0	0.2	-0.1	0.5	-0.1	1.4	-0.3	-0.6
Schizophrenia vs Biploar Disorder	0.2	0.3	0.6	-0.7	-0.1	-0.1	0.5	-0.8	-0.4	0.3	-0.4	0.3	-0.6	-0.7
Worry (Nagel 2018)	0.9	1.8	3.9	-0.1	0.1	1.9	-0.6	1.6	-0.4	-2.0	-1.6	-1.1	-1.8	-1.5
Alzheimer’s Disease (in mother)	1.8	2.1	5.2	0.6	1.4	0.6	2.0	0.3	0.4	2.2	2.3	1.5	1.4	1.4
Alzheimer’s Disease (in father)	1.4	1.5	3.4	1.2	1.7	1.4	-0.6	1.9	0.3	-1.5	-1.4	-1.2	-0.7	-0.6
Alzheimer’s Disease (including proxy)	0.8	1.1	3.9	1.4	2.0	1.1	1.1	1.4	0.2	0.7	1.0	0.2	0.6	0.7
Crohns Disease (2017)	3.3	7.3	18.5	4.3	2.1	-0.1	3.5	0.5	1.7	1.7	3.2	2.0	3.0	3.9
Irritable Bowel Disease (IBD)	3.4	8.2	18.2	3.6	-0.1	0.4	3.1	-0.5	1.5	2.8	4.3	3.0	3.5	4.2
Ulcerative Colitis (UC)	2.0	3.8	9.5	1.3	-2.1	0.6	1.8	-1.0	0.5	2.2	3.1	2.7	2.1	2.3
Major Depression (MDD)	1.0	1.2	4.5	-1.6	0.5	2.1	-1.2	-0.1	-0.5	0.7	0.6	-0.8	-1.0	-1.2
Reaction Time	0.6	1.2	5.6	2.4	1.9	0.7	0.6	0.5	0.3	-1.1	0.4	-1.1	-0.1	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	3.9	0.0	-0.0	-2.0	-0.3	0.4	0.2	0.5	-0.3	0.6	0.6	0.3
Breast Cancer	0.8	1.9	9.7	-0.4	-0.8	-1.6	-1.7	-3.1	-2.0	0.0	-0.5	-0.2	-0.0	-0.4
Ovarian Cancer	1.9	2.5	6.4	-0.0	-0.3	2.5	-1.3	1.9	-0.6	-2.2	-2.2	-0.9	-1.8	-1.5
Prostate Cancer	0.6	0.8	2.2	1.0	0.9	-1.1	1.2	-0.4	0.6	0.4	0.6	1.5	0.4	0.8
Age at First Birth	0.8	1.2	4.0	-2.0	-1.7	-0.4	-0.9	-1.0	0.2	-0.2	-1.8	-0.2	-0.2	-0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.2	1.3	0.8	-0.5	1.5	0.4	0.1	0.1	1.3	0.0	0.6	0.9
Coronary Artery Disease (CAD)	1.1	1.3	6.5	-1.0	-0.4	-1.8	-1.5	2.5	-0.9	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	2.3	3.7	9.0	2.6	1.4	0.0	1.8	0.1	1.4	1.8	2.4	1.1	2.7	3.0
Mean Putamen Volume	0.4	0.4	3.0	-0.6	-0.0	-1.7	0.4	-0.9	0.1	0.4	0.1	0.2	-0.1	-0.0
Fasting Glucose	2.9	3.5	9.7	-3.1	-2.2	-2.4	-2.2	-1.3	-2.0	-0.3	-1.9	0.6	-0.7	-1.7
HbA1C	0.7	0.8	2.7	-0.6	-1.3	-0.5	-1.6	-1.2	-0.9	0.8	-0.1	0.6	0.6	-0.1
HDL Cholesterol	0.2	0.4	1.3	-1.1	-0.2	0.8	-0.5	0.9	0.7	0.2	-0.6	0.4	0.0	-0.6
LDL Cholesterol	0.8	1.3	2.8	-0.2	-0.6	1.1	-1.6	0.4	1.4	-1.7	-1.6	-0.8	-0.8	-1.0
Lupus	0.5	0.7	2.0	0.7	-0.0	1.4	0.5	1.1	0.5	-1.0	0.1	-0.5	-1.4	-0.7
Neuroticism (2016)	0.9	1.2	3.3	-0.4	1.8	0.8	-0.2	1.4	0.8	-1.0	-0.4	-1.7	-1.3	-1.1
Primary Biliary Cirrhosis	0.4	0.6	2.3	0.4	0.8	-0.3	1.5	0.6	-0.0	0.7	0.6	-1.1	0.8	0.6
Rheumatoid Arthritis	0.5	0.7	1.6	1.3	0.5	-0.0	1.3	-0.5	0.2	0.8	1.1	0.7	0.6	1.2
Schizophrenia (2014)	0.2	0.5	2.2	-1.5	-1.3	-0.2	-0.2	0.1	-0.6	0.5	-0.4	0.5	-0.4	-0.8
Triglycerides	0.2	0.4	1.5	0.9	0.2	0.7	1.2	-0.2	-0.5	0.2	0.5	-0.2	0.4	0.7
Type 2 Diabetes (T2D) (2012)	1.6	1.9	6.5	-2.5	-1.6	-0.4	-1.9	-0.9	-1.6	0.2	-1.6	0.4	-0.2	-1.5
Ulcerative Colitis	1.1	1.6	4.7	0.8	-1.6	0.8	1.2	-0.4	-0.9	1.6	2.2	1.3	1.2	1.3
Blood Eosinophil Count	0.8	6.2	15.4	2.5	0.8	0.7	2.1	-0.5	3.9	2.7	3.0	1.3	3.5	3.4
Blood Platelet Count	0.6	6.4	24.6	1.1	3.3	0.8	1.0	-1.8	5.0	1.9	3.6	-1.2	2.4	2.2
Blood Red Count	0.2	1.8	3.7	0.6	-0.4	1.5	1.8	1.3	1.9	0.8	1.2	1.9	1.3	1.1
Blood White Count	0.3	2.1	7.8	-1.2	2.8	1.0	1.8	0.9	1.6	-0.5	-0.5	-2.0	-0.8	-1.0
Heel T-Score	0.6	4.7	11.6	-2.6	-1.7	-2.8	-3.4	-2.9	-3.3	0.9	-0.9	-0.0	0.2	-1.1
BMI	0.4	2.6	7.1	2.4	2.1	0.4	2.6	2.7	0.6	-0.6	0.9	-0.3	0.6	1.5
Height	0.2	4.7	21.2	1.2	2.9	0.2	3.5	4.6	2.2	-0.0	1.5	-0.1	0.3	0.7
Waist Hip Ratio (WHR)	0.3	1.2	2.8	-1.5	-1.7	-1.1	-0.8	-1.1	0.5	-0.4	-1.1	0.5	-0.8	-1.6
Systolic Blood Pressure	1.7	8.4	18.2	-2.0	-0.6	0.6	-0.7	2.4	-3.0	-3.7	-4.3	-2.4	-4.1	-4.1
Smoking Status	0.9	2.1	6.0	0.6	2.4	1.8	2.4	2.2	-0.2	-0.0	1.4	-0.7	-0.3	0.5
Allergy or Eczema	0.9	2.5	7.5	-2.3	-2.1	-0.8	-2.7	-2.7	0.3	1.0	-0.1	-0.4	0.8	-0.4
Cardiovascular Disease	1.9	6.2	15.2	-0.8	0.4	-1.0	-0.7	2.2	-2.4	-3.9	-3.3	-2.7	-3.5	-3.1
Hypothyroidism (self reported)	2.5	5.7	12.8	0.2	0.7	1.1	-0.8	3.5	-1.8	-3.6	-3.0	-3.3	-2.9	-2.0
Respiratory disease	0.7	1.6	6.0	-1.4	-0.3	-0.7	0.5	-1.8	-0.8	2.5	1.7	-0.1	1.2	0.8
Type 2 Diabetes (T2D) (2018)	2.2	4.1	11.3	-3.4	-2.7	-2.9	-2.0	-2.4	-0.1	0.9	-1.1	2.0	0.6	-1.3
Lung FEV1/FVC ratio	6.5	33.1	88.1	7.8	1.5	7.2	5.6	1.4	9.4	2.8	6.7	2.6	4.6	6.8
Lung FVC	1.5	7.7	18.2	-4.3	-0.3	-3.1	-4.2	-1.8	-2.3	-1.1	-3.2	-1.5	-2.3	-3.4
Neuroticism	0.3	0.7	2.3	0.6	-0.3	1.1	-0.2	0.5	0.1	-1.3	-0.6	-0.4	-1.5	-0.8
Chronotype (morning person)	1.3	3.0	8.4	2.5	2.9	0.2	2.9	0.3	1.0	0.7	1.9	0.4	1.1	1.8
Hair Pigment	0.0	0.8	1.6	-0.7	-1.0	-0.7	-0.3	1.3	0.9	-1.0	-0.9	-0.4	-1.0	-0.9
Tanning	0.1	1.7	5.2	-0.4	-0.3	0.2	1.7	-1.2	0.3	2.3	1.4	1.6	1.9	1.2
Hand grip strength (left)	0.7	1.8	3.7	-0.4	1.3	-1.3	-0.8	1.6	-1.9	-1.6	-1.6	-1.0	-1.3	-1.2
Number of treatments/medications taken	1.0	1.9	6.6	-1.0	0.1	-0.4	-2.6	-1.2	-2.1	-0.6	-0.8	-1.8	-1.1	-1.2
Average weekly spirits intake	0.6	0.8	2.4	-0.1	-0.1	1.0	1.3	-0.0	-0.1	1.5	1.6	-0.3	0.7	0.5
Sensitivity / hurt feelings	1.0	1.8	4.4	0.1	0.5	0.4	-1.8	2.1	0.0	-1.9	-1.6	-1.0	-1.6	-1.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	-0.4	-1.1	-0.1	-0.1	-0.5	0.2	-0.1	0.1	-0.7	-0.7	-0.6
Hearing difficulty/problems: Yes	1.8	2.8	5.7	2.4	0.4	-0.0	0.8	-1.5	1.0	1.7	2.1	1.9	2.1	2.3
Relative age of first facial hair	0.5	1.1	2.9	-0.1	-0.5	0.7	-1.6	0.2	-0.7	-1.4	-1.7	-0.9	-1.1	-1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.0	1.1	0.7	-0.4	0.3	-1.5	0.4	0.8	1.7	0.6	0.6	0.8
Ever used hormone-replacement therapy (HRT)	1.4	1.8	4.1	0.8	-0.0	-0.4	1.8	-2.0	0.3	1.6	1.6	1.6	1.2	1.4
Ever had hysterectomy (womb removed)	1.0	1.2	4.9	0.3	-1.4	-0.3	-0.4	-1.1	-0.3	1.4	0.8	2.2	1.2	0.6
Systolic blood pressure, automated reading	0.5	1.5	3.1	-0.4	0.5	0.3	1.3	1.7	-1.1	-1.4	-1.6	-1.1	-1.8	-1.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	-0.6	-0.3	0.2	0.5	0.1	-0.2	0.1	-0.5	-0.3	0.1	-0.4
Angina	0.7	1.0	3.3	1.8	0.3	-0.8	-0.1	1.6	1.0	-1.3	-0.6	-0.7	0.0	0.4
Medication for hormone replacement therapy	1.3	1.5	3.7	0.8	0.5	1.0	0.8	-1.9	1.2	1.3	1.9	0.1	1.2	1.3
Vitamin and mineral supplements	0.8	1.1	5.9	-0.4	2.4	1.3	1.4	0.3	0.8	0.2	0.6	-0.4	-0.7	-0.6
Supplements: Zinc	0.7	0.8	2.8	0.0	-1.2	-1.7	-0.1	0.0	1.2	0.7	0.4	0.7	0.9	0.8
Medication: Co-codamol	4.4	5.1	10.4	1.7	-0.2	1.5	1.6	-2.2	1.8	2.6	2.7	3.2	2.7	2.9
Medication: Metformin	1.6	2.3	9.1	-3.0	-2.3	-1.2	-0.8	-1.7	0.1	0.7	-1.2	1.4	0.2	-1.3
Diabetes (father)	0.3	0.4	1.0	-0.4	-1.0	-1.0	-0.7	-0.8	-0.4	0.4	-0.3	0.6	0.7	0.1
Diabetes (mother)	2.6	3.3	12.6	-3.5	-2.5	-0.5	-3.1	-1.1	-0.5	0.6	-1.3	0.8	-0.1	-1.8
Severe depression (siblings)	0.5	0.6	2.1	-0.7	0.3	0.8	-0.6	0.6	-0.9	0.2	0.3	-1.5	-0.8	-0.9
Pack years adult smoking proportion	3.7	5.7	10.8	1.5	1.0	1.5	2.9	-1.4	1.2	3.3	3.3	1.8	3.2	3.2
Impedance of leg (right)	0.5	2.6	10.0	-1.6	-0.3	-1.2	-3.1	-3.2	-0.6	-0.1	-1.3	-0.3	-0.7	-1.5
Leg fat-free mass (left)	0.9	4.8	20.8	1.7	2.7	1.9	3.7	4.6	0.7	-0.6	1.3	-0.9	-0.1	0.9
Trunk fat percentage	0.5	1.9	6.0	1.3	2.5	1.5	2.1	1.1	0.6	0.5	1.9	-0.5	0.4	0.9
Hand grip strength (right)	0.2	0.6	2.5	-0.0	0.9	-0.4	0.3	1.6	-1.2	-0.5	-0.3	-0.8	-0.4	-0.4
Townsend deprivation index at recruitment	0.3	0.4	1.4	0.3	1.0	0.7	0.6	-0.4	-1.2	0.6	0.5	-0.1	0.1	0.1
Current tobacco smoking	1.5	2.5	14.5	0.6	1.6	3.8	2.0	0.9	0.6	0.9	1.4	0.0	0.8	1.0
Average weekly fortified wine intake	0.1	0.2	0.9	-0.7	-0.9	-0.1	-0.4	-0.4	-0.2	0.2	-0.2	-0.3	0.2	-0.0
Maternal smoking around birth	0.7	1.0	5.3	0.9	1.4	0.2	1.1	2.3	0.7	-0.2	1.0	-0.2	-0.2	0.4
Fed-up feelings	0.2	0.4	1.3	-0.1	0.4	0.9	0.1	0.1	-0.2	-0.6	0.1	-1.2	-0.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	2.5	-0.5	-1.6	0.1	0.8	0.1	-0.6	0.2	0.4	0.1	-0.7	-0.4
Relative age voice broke	0.5	0.8	4.2	0.1	-2.0	0.2	-1.5	-0.8	-0.3	0.1	-0.6	1.2	0.4	0.1
Taking other prescription medications	0.7	1.1	2.8	-0.2	-0.2	-1.2	-1.5	0.1	-1.7	-0.6	-0.6	-1.6	-1.2	-1.2
Age when periods started (menarche)	1.2	3.0	6.1	-1.1	0.1	2.0	-1.8	1.4	-0.8	-1.9	-2.1	-2.5	-1.9	-1.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.3	0.1	-0.3	1.0	-1.1	-1.8	-1.2	0.3	0.3	0.7	0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.7	-0.2	-0.3	-0.7	-0.8	-1.1	-1.3	0.5	0.5	0.2	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	3.7	0.2	1.9	0.3	0.8	0.9	0.6	-0.6	-0.2	-1.9	-0.5	-0.3
Qualifications: CSEs or equivalent	0.4	0.5	1.5	1.0	1.2	1.0	0.4	0.7	0.6	-0.0	0.8	0.1	0.2	0.3
Serious illness, injury or assault to yourself	0.2	0.3	1.0	1.0	-0.1	-0.0	-0.4	0.7	-1.0	-0.4	0.4	0.2	-0.2	0.3
High blood pressure	0.7	1.9	4.2	0.3	1.1	-1.3	-0.0	1.4	-1.2	-2.0	-1.8	-1.9	-1.3	-1.2
Hayfever, allergic rhinitis or eczema	1.1	2.4	7.5	-2.6	-1.9	-0.9	-2.3	-2.7	0.3	0.8	-0.2	-1.0	0.6	-0.7
Multivitamins +/- minerals	0.7	0.9	4.6	0.4	-1.1	-2.1	-1.1	-0.6	-0.1	0.2	-0.5	-0.6	0.9	0.8
Stomach or abdominal pain in last month	0.8	1.0	2.5	-1.6	0.2	-1.2	-0.9	0.4	-0.4	-0.3	-0.9	-1.5	-0.9	-1.2
Supplements: Glucosamine	0.5	0.7	4.2	-0.4	-1.2	-2.0	-0.2	0.0	-0.9	-0.4	-0.9	-0.1	0.0	-0.1
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	5.0	-1.9	-0.8	-1.0	-2.1	-0.8	-1.7	-1.0	-1.8	-1.3	-1.5	-2.2
Medication: Atenolol	0.4	0.4	1.4	0.8	0.8	-0.3	-0.7	0.4	-1.2	-0.6	-0.6	-0.8	0.3	0.2
Medication: Levothyroxine sodium	2.5	4.2	9.4	-1.2	-0.4	0.6	-1.1	3.1	-2.0	-2.6	-2.4	-2.4	-2.6	-2.2
Sitting height	0.4	2.6	13.9	-0.7	1.3	0.9	2.9	3.7	-0.0	-0.9	-0.5	-0.8	-1.0	-0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	1.0	-0.0	-0.3	-0.3	0.3	-0.7	0.2	0.4	-0.1	1.0	0.4	0.3
High blood pressure (mother)	0.2	0.2	0.7	0.2	-0.2	0.8	-0.1	-0.1	-0.8	-0.4	-0.5	0.8	-0.0	0.1
Body mass index (BMI)	0.3	1.4	3.8	1.2	2.0	1.0	1.8	1.8	-0.4	0.1	1.4	-0.8	-0.1	0.6
Impedance of leg (left)	0.5	2.6	10.0	-1.9	-0.9	-1.4	-2.7	-3.2	-0.7	0.0	-1.2	-0.1	-0.6	-1.5
Leg predicted mass (left)	0.9	4.7	20.2	1.7	2.6	1.9	3.7	4.5	0.7	-0.6	1.3	-0.9	-0.0	0.9
Trunk fat mass	0.6	2.6	8.2	1.4	2.9	1.4	2.7	2.1	0.4	0.1	1.7	-0.7	0.2	0.8
Waist circumference	0.5	1.8	6.1	1.1	2.4	0.8	1.9	2.5	-0.5	-0.6	0.8	-0.9	-0.7	-0.0
Number of incorrect matches in round	0.2	0.4	1.2	-0.7	0.3	-1.1	-0.1	0.1	-0.3	-0.4	-0.5	-1.0	-0.5	-0.6
Past tobacco smoking	0.5	1.0	3.6	-1.0	-0.8	0.9	-0.7	-1.9	1.5	0.9	-0.4	0.0	0.9	-0.0
Alcohol usually taken with meals	0.6	1.0	4.9	0.3	-1.6	-0.8	-1.3	-0.4	2.2	-0.0	-0.4	-0.2	1.0	0.6
Nervous feelings	0.2	0.4	4.3	0.1	-0.1	2.1	0.2	0.5	0.2	-0.2	-0.0	-0.1	-0.2	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.4	0.1	-1.2	-0.2	-0.2	-0.4	0.0	-0.2	0.0	-0.4	-0.4	-0.5
Hearing difficulty/problems with background noise	0.7	1.2	5.0	2.2	0.4	-1.9	-0.6	-0.2	-0.3	-0.2	1.2	0.6	0.7	1.1
Hair/balding pattern: Pattern 2	1.7	2.2	4.8	1.3	0.7	-1.3	1.8	-0.9	1.1	1.8	1.6	0.9	2.2	2.0
Had menopause	1.2	1.5	4.9	-0.9	-1.2	-2.2	-0.9	-2.1	0.0	0.9	-0.1	1.7	0.7	-0.0
Had other major operations	1.1	1.4	4.0	-0.4	-1.6	-1.2	-1.9	0.3	-2.0	-0.8	-0.4	0.4	-1.0	-1.0
Forced vital capacity (FVC)	0.6	2.5	8.5	-2.9	-0.1	-0.5	-1.2	0.7	-0.0	-1.4	-1.9	-1.1	-1.9	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	4.1	0.1	-0.1	-0.2	-0.4	-2.0	-1.1	0.5	0.7	0.3	-0.1	0.0
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.5	-1.2	-1.2	-1.4	-1.7	-1.2	-2.1	0.5	-0.2	-1.6	-0.4	-1.0
Qualifications: None of the above	0.7	1.4	7.8	1.5	1.5	2.8	1.2	0.6	-0.5	-0.3	0.6	0.3	-0.0	0.7
Financial difficulties in last 2 years	1.0	1.4	4.4	0.7	1.8	1.6	0.7	-0.6	0.7	1.0	2.1	-1.2	0.5	0.6
Mouth/teeth dental problems	0.8	1.2	5.9	-0.6	-2.4	-0.8	-1.3	-1.0	-0.4	-0.2	-1.3	1.1	0.3	-0.4
Heart attack	0.7	0.9	4.5	2.1	0.1	0.2	-0.9	0.2	1.2	0.0	0.8	0.7	1.1	1.1
Allergy	0.9	2.0	7.2	1.9	1.7	1.1	1.4	2.7	-0.1	-1.8	-0.9	-0.0	-1.2	-0.1
Pain all over the body in last month	0.9	1.0	2.8	-1.7	0.7	1.4	-0.3	-0.7	1.4	0.8	1.5	0.1	-0.3	-0.4
Diabetes (self-reported)	1.3	2.0	6.4	-2.5	-2.1	-1.8	-0.6	-1.3	0.5	0.6	-0.9	1.6	0.2	-1.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.3	-2.3	-0.2	-2.3	-0.5	-0.7	0.5	-0.7	-0.9	-0.7	-1.4	-1.9
Medication: Ramipril	1.0	1.3	4.0	-0.0	0.1	-1.8	-0.3	-0.5	-2.0	-1.3	-1.5	-0.9	-1.1	-1.1
Medication: Simvastatin	0.5	0.7	4.3	0.4	2.1	-1.3	0.2	0.3	-0.0	-0.1	-0.1	-1.3	0.2	0.3
Fluid intelligence score	1.0	2.1	6.5	-0.2	-1.4	-2.5	0.1	-1.0	0.4	2.1	1.1	1.8	1.8	1.3
Illnesses of siblings	2.0	2.8	5.3	1.3	-0.2	1.6	1.7	-1.0	2.1	1.9	2.3	1.5	1.8	1.9
Neuroticism score	0.2	0.4	1.2	0.7	-0.4	0.7	0.1	1.1	-0.3	-0.8	-0.1	-0.6	-0.8	-0.4
Weight	0.6	2.9	11.8	1.0	2.5	1.1	2.8	3.4	-0.1	-0.4	1.3	-1.2	-0.4	0.4
Impedance of arm (right)	0.2	0.7	1.7	-0.5	-1.3	1.1	-0.7	-1.2	1.2	0.6	0.2	1.0	0.6	0.0
Arm fat percentage (right)	0.4	1.7	4.2	1.3	1.9	1.5	2.0	1.1	0.4	0.6	1.9	-0.0	0.6	1.1
Trunk fat-free mass	0.3	1.8	9.7	0.7	1.1	-0.0	2.7	3.1	0.2	-0.4	0.6	-0.5	-0.1	0.5
Hip circumference	0.8	3.6	10.6	2.0	3.1	1.7	2.7	3.3	0.4	-0.7	1.3	-1.4	-0.3	0.9
Time employed in main current job	1.0	1.1	3.3	-0.4	-1.6	-1.1	-0.7	-1.8	-1.2	1.2	0.2	0.7	0.8	0.4
Alcohol intake versus 10 years previously	1.0	1.5	3.6	0.6	1.9	0.7	1.2	-0.7	1.0	1.3	1.1	1.6	1.4	1.2
Father’s age at death	0.7	1.0	2.6	0.0	-1.6	0.5	-0.5	1.5	1.4	-1.0	-1.6	0.4	0.0	-0.1
Worrier / anxious feelings	0.7	1.4	5.5	0.5	-1.2	1.1	-0.6	2.3	-0.2	-1.6	-1.1	-0.1	-1.2	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.0	-0.2	-1.0	0.1	0.3	0.7	0.5	-0.2	-0.4	0.5	-0.5	-0.4
Falls in the last year	0.8	1.1	5.3	-0.4	-1.1	-2.3	-1.9	-0.2	-0.1	-0.5	-1.0	-0.3	-0.1	-0.5
Hair/balding pattern: Pattern 3	1.4	2.0	3.6	-1.6	-0.6	0.1	-1.5	0.9	-1.8	-1.4	-1.9	-1.5	-1.6	-1.7
Number of live births	0.1	0.2	0.5	0.5	-0.2	0.2	0.6	0.5	0.0	-0.5	0.0	0.6	-0.7	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.8	-0.9	0.7	1.6	0.3	1.2	2.2	-0.6	-0.1	-0.7	-0.8	-0.7
Pulse rate	0.8	1.3	4.3	0.9	1.2	0.9	2.1	1.1	0.9	0.6	1.5	-0.8	0.7	1.1
Happiness	0.4	0.5	3.1	-0.5	0.1	0.5	-0.4	0.3	-0.9	-0.3	0.1	-1.8	-0.8	-0.7
Noisy workplace	0.5	0.6	1.7	0.5	0.2	1.3	-0.9	0.7	-0.7	-1.1	-0.2	-0.7	-0.9	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.7	-1.1	-2.2	-1.5	-1.1	-0.1	0.1	-0.3	-1.3	0.5	-0.6	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.5	-1.8	-1.2	-0.1	-1.6	0.9	-0.5	-1.3	-1.8	-1.7	-1.4	-1.9
Mouth/teeth dental problems: Dentures	1.9	3.2	11.4	1.8	2.5	2.5	3.4	1.1	0.8	0.4	2.2	0.6	0.0	1.0
Asthma	0.5	0.9	2.4	-1.2	-0.2	-1.5	0.2	-0.9	-0.3	1.6	1.1	-0.7	0.8	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	4.1	0.6	2.0	0.6	-0.2	0.6	0.4	-0.2	0.2	-0.9	0.1	0.4
Medication: Cholesterol lowering	0.7	1.2	3.7	0.5	-0.2	-1.9	-1.9	0.8	-0.3	-1.3	-1.2	-0.8	-0.4	-0.6
Depression (self-reported)	0.3	0.3	1.4	-0.2	0.8	0.4	-0.2	0.1	-0.3	-0.3	-0.7	-1.2	-0.8	-0.5
Medication: Lansoprazole	1.6	1.8	6.9	-0.4	1.3	0.2	-1.7	-0.1	-2.6	-1.3	-1.0	-0.7	-1.7	-1.5
Prospective memory result	1.2	1.4	3.4	1.1	0.8	1.0	-0.4	1.7	0.9	-1.9	-1.6	-1.6	-0.8	-0.3
Lung cancer (father)	1.0	1.2	4.1	-1.4	2.0	0.3	1.0	0.6	-0.5	-0.5	-0.1	-0.9	-1.6	-1.3
Illnesses of mother	0.6	0.8	2.6	-0.2	-0.1	-0.3	0.3	0.9	-0.3	-1.2	-0.4	-1.4	-1.6	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.3	-1.1	0.8	1.8	-0.3	1.4	1.6	-1.1	-0.8	-0.7	-1.4	-1.1
Pulse wave Arterial Stiffness index	1.5	1.7	7.0	-0.3	-0.8	-1.3	1.5	-2.6	-0.4	1.8	1.5	0.3	0.9	0.8
Impedance of arm (left)	0.1	0.6	2.5	-0.4	-0.4	1.5	-0.8	-0.7	1.6	0.2	0.0	0.1	0.3	-0.2
Arm fat mass (right)	0.5	2.0	5.8	1.2	2.4	1.3	2.3	2.2	0.1	0.1	1.5	-0.7	0.0	0.7
Trunk predicted mass	0.3	1.8	10.2	0.7	1.1	-0.0	2.7	3.2	0.1	-0.5	0.5	-0.6	-0.2	0.4
Standing height	0.3	2.6	14.9	0.0	1.8	0.6	2.7	3.9	0.9	-0.9	0.3	-1.0	-0.5	-0.1
Length of working week for main job	2.6	2.9	6.1	1.8	0.7	0.2	2.1	-1.3	1.1	1.9	2.5	1.4	2.0	2.2
Exposure to tobacco smoke at home	0.3	0.3	2.2	0.0	1.5	-0.3	-0.1	0.3	-0.3	0.1	-0.8	0.2	-0.3	-0.4
Breastfed as a baby	0.6	0.8	1.9	0.0	-1.1	-1.2	0.3	-0.9	1.1	1.0	0.5	1.4	0.6	0.3
Tense / ‘highly strung’	0.2	0.4	0.9	0.3	-0.7	-0.9	-0.5	0.4	-0.8	-0.5	-1.0	-0.4	-0.3	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	6.5	0.8	1.1	0.8	-1.2	1.7	0.3	-2.1	-1.2	-2.5	-1.4	-0.8
Hair/balding pattern: Pattern 4	0.3	0.6	2.2	-0.4	-0.5	-0.5	-1.5	-1.4	0.9	-0.2	-0.8	-0.4	-0.1	-0.5
Birth weight of first child	0.7	1.2	6.0	-2.1	-0.6	-2.4	0.4	-0.5	-0.2	1.3	0.8	-0.4	-0.1	-0.5
Peak expiratory flow (PEF)	0.5	1.1	5.8	0.2	1.0	1.4	0.7	0.3	2.4	0.6	1.1	0.1	0.8	0.6
Pulse wave reflection index	2.0	2.4	9.4	-1.6	-1.7	-0.8	-1.1	-3.1	-2.5	0.2	-0.2	0.7	-1.1	-1.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.1	-0.3	-0.5	0.1	0.1	-0.4	-0.3	1.1	0.9	-0.1	1.0	0.4
Loud music exposure frequency	1.4	1.5	3.6	0.8	-1.3	1.3	0.6	-0.7	1.5	1.6	0.9	0.5	1.9	1.4
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.6	-0.1	-0.1	-1.9	-1.8	0.7	0.8	-0.5	-0.6	-1.2	0.2	-0.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.6	-0.5	0.8	1.3	-0.4	1.0	-0.3	-0.4	-0.4	-1.2	-0.4	-0.3
Blood clot in the leg (DVT)	0.5	0.6	2.4	1.0	0.1	-0.3	-0.4	-0.1	-0.0	0.8	1.6	0.7	0.9	1.1
Medication: Paracetamol	1.9	3.2	5.9	-1.7	0.7	1.0	-2.3	0.6	-1.4	-1.8	-1.7	-2.2	-2.4	-2.4
Headache pain in last month	2.9	5.0	10.6	-2.5	-0.2	-2.1	-2.8	0.9	-1.1	-2.2	-3.2	-1.8	-2.6	-3.0
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	7.6	-0.3	-0.4	2.0	2.7	-0.0	0.6	2.1	2.2	2.2	0.7	0.9
Glaucoma (self-reported)	0.6	0.7	2.6	1.6	0.6	-0.5	-0.1	-0.2	1.4	0.1	0.5	1.0	0.7	0.8
Gout (self-reported)	0.5	0.7	2.8	-0.4	-0.3	-1.1	-0.1	0.7	-1.7	-0.7	-0.6	-1.2	-0.7	-0.7
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	11.2	-0.3	0.2	0.8	-1.2	3.3	-2.0	-2.9	-2.7	-3.0	-2.6	-2.0
Medication: Amlodipine	0.7	0.9	2.2	0.4	-0.8	0.1	0.1	1.2	-1.5	-1.4	-0.8	-1.3	-1.1	-0.6
Medication: Ventolin 100micrograms inhaler	1.9	2.5	8.1	0.3	-0.2	-0.0	0.2	-2.0	0.3	2.8	2.9	1.0	1.7	1.6
Birth weight	0.2	0.4	1.7	-1.3	-0.8	0.5	-0.2	-0.1	-1.0	0.4	0.5	0.4	-0.5	-0.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.6	-0.5	1.5	-0.0	-0.0	0.2	-1.9	-0.6	-0.7	-0.2	-1.2	-1.2
High blood pressure (siblings)	1.7	2.5	6.2	-1.6	0.7	-1.1	-0.9	0.5	-2.5	-1.5	-2.1	-1.5	-1.7	-1.9
Forced vital capacity (FVC), Best measure	0.8	2.9	9.9	-3.1	-0.3	-0.2	-1.6	0.6	-1.0	-1.3	-1.9	-0.7	-2.3	-2.6
Body fat percentage	0.4	1.6	6.2	1.1	2.5	1.4	1.9	0.9	0.2	0.4	1.6	-0.6	0.2	0.7
Leg fat percentage (right)	0.2	0.8	5.2	0.7	2.3	0.6	0.8	0.4	-0.5	0.3	1.1	-0.5	-0.2	0.2
Arm fat-free mass (right)	0.5	2.6	10.0	1.0	2.5	0.5	2.9	3.2	0.2	-0.5	0.8	-1.1	-0.2	0.5
Exposure to tobacco smoke outside home	0.4	0.5	1.7	-0.2	0.7	-0.1	-1.1	-0.8	-0.9	-0.0	-1.3	-0.5	-0.1	-0.4
Comparative body size at age 10	0.5	1.3	5.2	-0.3	0.8	0.3	0.5	-0.4	0.9	1.9	2.3	0.8	1.3	1.1
Number of full brothers	0.7	0.8	3.1	1.5	-0.2	0.9	1.8	0.5	0.5	-0.8	-0.7	1.1	0.1	0.6
Worry too long after embarrassment	0.6	0.9	4.4	2.1	0.2	-0.1	-0.7	1.1	0.9	-1.5	-0.1	-1.0	-0.3	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.9	1.7	0.7	1.7	0.4	-0.2	1.6	0.5	1.3	0.2	1.1	1.2
Wheeze or whistling in the chest in last year	0.4	0.7	3.3	-1.5	0.1	0.1	-0.2	-0.6	-1.8	0.3	-0.0	-0.9	-0.6	-0.8
Number of children fathered	1.7	1.9	6.9	1.6	2.6	1.1	1.5	1.9	1.4	-0.2	1.2	0.0	0.5	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	4.4	-0.2	-2.1	0.4	-1.3	-0.9	0.0	-0.1	-0.3	0.4	-0.3	-0.3
Age at first live birth	0.9	1.5	3.5	-1.8	-1.9	-0.2	-1.5	-0.7	-1.4	-0.4	-1.5	-1.0	-0.9	-1.2
Pulse wave peak to peak time	1.5	1.8	8.1	0.5	1.1	1.3	-1.3	2.8	0.7	-1.8	-1.4	-0.3	-0.9	-0.6
Health satisfaction	0.5	0.7	3.3	0.2	-0.7	-1.3	0.1	0.9	0.4	-0.8	-0.2	-1.8	-0.5	-0.3
Shortness of breath walking on level ground	0.5	0.7	2.9	-0.2	-0.6	-0.9	-0.3	-1.7	-0.3	1.2	0.4	-0.6	0.9	0.3
Qualifications: College or University degree	0.6	1.7	9.2	-1.1	-3.0	-1.1	-0.6	-2.2	-0.2	1.0	-0.2	0.9	0.5	-0.1
Eye problems/disorders: None of the above	1.7	1.9	4.0	-0.7	2.0	1.1	-0.5	0.2	-0.9	-1.7	-1.4	-1.8	-2.0	-1.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	4.6	0.3	0.1	-2.1	0.3	-0.3	-1.3	0.6	0.6	1.3	0.2	0.3
Emphysema/chronic bronchitis	0.3	0.4	2.7	-0.6	-0.3	-0.1	0.1	-0.6	-1.6	0.7	-0.4	0.1	0.0	-0.3
Medication for pain relief, constipation, heartburn	1.4	2.4	9.7	1.3	-1.4	-0.5	3.1	0.8	1.4	1.0	0.5	2.1	1.5	1.5
Neck or shoulder pain in last month	0.3	0.4	1.3	-0.9	-0.5	-0.5	-0.4	0.2	1.1	-0.1	-0.3	-1.0	0.0	-0.4
Medication: Blood pressure	0.9	1.5	4.7	0.4	0.7	-1.6	-2.2	-0.9	-0.7	-1.1	-1.7	-1.8	0.1	-0.4
Angina (self-reported)	0.6	0.9	3.0	1.7	0.6	-0.6	-0.1	1.7	0.8	-1.1	-0.4	-0.8	-0.0	0.4
Migraine (self-reported)	0.5	0.7	2.2	-0.8	-0.5	1.1	0.3	-0.0	-0.7	1.3	0.4	1.5	0.7	0.4
Medication: Ibuprofen	0.4	0.5	4.0	0.3	2.0	0.7	0.3	0.3	0.2	-0.1	0.3	-0.9	-0.2	0.2
Medication: Allopurinol	0.6	0.8	3.1	-1.1	0.8	-1.4	-0.0	-0.1	-1.8	-0.2	-0.2	-1.0	-0.3	-0.7
Medication: Omeprazole	0.6	0.7	3.2	0.7	1.3	-0.5	-1.1	1.0	-0.4	-0.4	0.4	-1.8	-0.2	-0.2
Medication: Seretide 50 evohaler	1.1	1.3	3.5	0.9	-1.6	-0.8	-0.4	-0.8	0.4	1.1	0.5	1.9	1.5	1.4
Mean time to correctly identify matches	0.3	0.6	3.6	1.9	1.3	-0.3	0.4	-0.1	-0.5	-0.6	0.3	-0.3	0.0	0.6
Heart disease (mother)	0.6	0.7	2.7	1.6	0.5	-1.3	0.7	-0.1	0.5	0.3	0.5	-0.4	0.8	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	5.6	0.2	-0.1	-0.8	-0.2	1.7	0.1	-2.4	-1.9	-1.9	-1.2	-1.2
Whole body fat mass	0.6	2.4	8.8	1.3	3.0	1.3	2.4	2.3	0.2	-0.2	1.3	-1.0	-0.2	0.5
Leg fat mass (right)	0.5	2.0	9.4	1.0	3.1	1.0	1.7	2.1	-0.6	-0.6	0.8	-1.2	-0.7	0.0
Arm predicted mass (right)	0.4	2.3	10.0	0.8	2.3	0.3	2.6	3.2	-0.1	-0.6	0.5	-1.1	-0.3	0.3
Pulse rate, automated reading	1.5	4.7	10.6	2.3	3.2	2.1	3.1	1.8	2.3	1.0	2.7	0.1	1.1	2.0
Alcohol intake frequency.	0.9	2.2	4.7	1.7	2.1	1.6	2.2	-0.2	0.8	1.1	2.0	0.6	0.9	1.6
Comparative height size at age 10	0.3	1.5	6.2	-0.5	1.8	-0.2	2.5	1.4	-0.3	1.1	1.1	0.8	0.9	0.7
Number of full sisters	0.5	0.6	2.0	0.1	1.3	0.6	0.7	1.4	-0.1	0.3	1.3	-0.1	-0.4	0.0
Suffer from ‘nerves’	0.4	0.6	2.9	0.3	0.1	1.7	-0.2	1.4	0.2	-0.4	-0.6	-1.2	0.0	0.1
Overall health rating	1.1	2.4	8.3	-0.1	0.9	0.4	0.2	2.9	-0.8	-1.9	-0.8	-2.0	-2.2	-1.7
Chest pain or discomfort	0.2	0.4	0.9	-0.1	-0.0	-0.9	0.7	-0.9	-0.7	0.4	0.5	0.9	-0.1	0.0
Had major operations	1.1	1.3	3.6	0.6	1.0	1.2	0.9	1.7	0.9	-1.9	-1.5	0.9	-0.8	-0.4
Age at last live birth	0.7	1.1	3.0	-1.4	-0.6	0.5	-0.3	-0.1	-1.7	-1.0	-1.3	-0.3	-1.4	-1.1
Family relationship satisfaction	0.3	0.3	1.0	-0.9	-0.6	-0.2	-0.1	0.0	-0.3	-0.1	0.4	-0.9	-1.0	-0.8
Leg pain on walking	0.6	0.7	2.2	1.2	0.0	-1.5	0.9	-0.5	1.1	0.1	0.4	0.3	1.0	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.9	0.9	0.7	-1.0	-1.4	1.1	-0.5	-0.5	-0.4	-0.2	0.2	0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.9	1.5	-0.0	2.0	-0.0	1.0	0.5	-0.9	-0.1	-0.2	-0.3	0.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.8	-1.1	-2.2	-0.3	-0.1	-0.8	-0.3	1.1	0.0	2.1	0.7	0.1
Medication: Aspirin	0.7	0.9	2.9	-0.6	-1.0	-1.1	-1.7	-1.2	-1.6	0.2	0.4	0.8	-0.2	-0.4
Supplements: Vitamin C	0.5	0.6	3.5	0.4	-1.9	1.1	-0.8	-0.6	-0.0	-0.1	-0.0	1.0	0.1	-0.0
Knee pain experienced in last month	1.8	2.8	6.2	-0.4	0.6	0.2	-2.3	2.3	-0.8	-2.5	-2.0	-1.3	-1.9	-1.9
Hypertension (Self-reported)	0.7	1.8	3.8	0.4	1.2	-1.8	0.1	1.3	-1.3	-2.0	-1.5	-1.7	-1.3	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	8.4	-0.7	-0.0	-1.2	-2.9	-0.1	-2.4	-0.6	-0.9	-1.4	-0.6	-0.9
Illnesses of father: Heart disease	1.1	1.5	4.7	-1.9	-0.3	-1.8	-0.8	-2.2	-1.6	0.6	-0.1	-0.0	-0.6	-0.9
Illnesses of siblings: Diabetes	2.0	2.5	5.9	-1.9	-2.4	-1.5	-2.2	-0.5	-1.5	-0.9	-2.0	0.5	-0.8	-1.6
Smoking status: Previous	0.5	0.8	3.7	-0.4	-0.4	-1.5	0.3	1.1	-1.9	-0.5	0.2	-0.0	-0.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	3.0	6.3	16.5	-1.0	1.1	0.9	0.0	4.1	-1.9	-3.2	-2.8	-2.8	-3.4	-2.8
Whole body fat-free mass	0.5	3.0	14.6	1.1	1.8	0.7	3.3	3.8	0.4	-0.5	0.9	-0.7	-0.1	0.7
Leg fat-free mass (right)	0.9	4.7	22.0	1.4	2.3	1.9	3.9	4.7	0.7	-0.7	1.1	-0.9	-0.1	0.8
Arm fat percentage (left)	0.5	2.1	6.0	1.4	2.4	2.0	2.2	1.4	0.5	0.5	1.8	-0.3	0.4	1.0
Average weekly red wine intake	0.3	0.5	2.0	0.2	0.2	-1.4	0.0	-0.4	0.7	0.8	0.1	0.1	1.1	0.7
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.6	-0.1	0.1	-0.8	-1.2	0.3	-0.7	-1.6	-1.2	-0.3	-0.9	-0.8
Mood swings	0.3	0.6	3.0	0.1	-0.3	1.7	1.1	0.4	-0.6	0.2	0.6	-0.7	-0.7	-0.2
Loneliness, isolation	0.5	0.6	4.0	-0.3	1.2	0.2	2.0	-0.2	-0.2	0.9	0.6	0.0	-0.2	0.1
Long-standing illness, disability or infirmity	0.8	1.1	6.9	-0.3	-0.3	-2.6	-1.4	-1.7	-0.2	0.3	-0.4	0.6	0.3	-0.3
Ever had bowel cancer screening	0.3	0.3	1.5	0.1	-1.2	-0.7	0.1	-0.3	0.8	0.2	0.0	0.7	-0.2	-0.1
Diabetes diagnosed by doctor	1.8	3.0	9.6	-3.1	-2.8	-2.3	-1.1	-1.6	-0.3	0.5	-1.2	1.6	0.1	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.6	-0.6	0.9	1.4	-0.1	-1.9	-0.9	1.8	1.2	1.3	1.4	0.9
Friendships satisfaction	0.3	0.4	1.8	-0.3	-0.2	1.1	0.4	0.5	-1.4	0.0	0.3	-0.8	-0.4	-0.0
Qualifications: nursing, teaching	1.5	2.4	8.5	0.2	-2.9	-0.8	-1.4	-2.5	0.4	0.9	-0.1	2.4	1.3	0.7
Commuting to job workplace: Walk	0.8	0.9	2.9	-0.4	0.2	-1.6	-0.5	-1.7	-0.8	1.2	1.2	0.1	0.3	0.3
Eye problems/disorders: Cataract	1.6	1.8	4.9	-0.1	-1.1	-0.2	0.5	-0.6	1.1	2.2	1.8	1.5	2.0	1.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.5	-0.6	-1.2	-0.3	-0.8	-0.2	0.1	0.6	0.6	-0.8	0.1	0.1
Medication for cholesterol	0.4	0.6	1.5	1.0	-0.0	-1.0	-0.8	0.5	1.2	0.0	-0.1	0.4	1.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	2.7	-0.1	-0.3	-0.2	-1.6	-0.7	0.0	-0.1	-0.9	-0.1	0.4	-0.1
Back pain experienced in last month	0.5	0.7	3.7	-0.1	-0.3	-0.2	-0.8	1.3	-1.9	-0.5	-0.4	-0.6	-0.9	-0.6
Mineral and other dietary supplements	0.6	0.8	2.8	0.7	1.7	0.6	1.1	0.5	1.4	0.4	0.6	1.0	0.3	0.4
Breast cancer (self-reported)	0.3	0.3	1.0	1.0	0.4	0.4	0.7	0.9	0.4	-0.1	0.6	0.4	-0.1	0.2
Asthma (self-reported)	0.4	0.8	2.7	-1.6	-0.0	-1.4	0.2	-0.6	-0.6	1.3	0.9	-1.1	0.3	0.1
Osteoporosis (self-reported)	1.0	1.2	4.5	-0.2	-0.3	1.2	0.7	-0.7	-0.1	1.9	2.1	0.8	0.9	0.9
Osteoarthritis (self-reported)	0.1	0.2	1.3	0.1	0.3	-0.4	0.1	-0.6	1.1	-0.1	0.1	0.1	0.2	0.1
Medication: Aspirin	0.8	1.1	3.5	-0.9	-0.8	-1.3	-1.9	-1.0	-1.7	0.1	0.2	0.8	-0.4	-0.6
Medication: Gliclazide	0.8	1.0	4.1	-1.3	-0.5	0.3	-1.3	-0.9	-0.7	1.2	-0.2	2.0	0.5	-0.2
Illnesses of father: None of the above (group 1)	1.3	1.6	3.5	1.9	-0.5	0.2	1.8	1.9	1.6	0.2	1.4	0.7	0.7	1.3
Smoking status: Current	1.3	2.1	11.9	0.9	1.8	3.4	1.8	1.2	0.5	0.5	1.1	-0.1	0.5	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	4.8	-0.3	-0.9	0.4	-0.3	0.4	2.2	0.1	-0.4	1.6	0.4	0.3
Whole body water mass	0.5	3.0	14.4	1.2	1.8	0.9	3.2	3.8	0.4	-0.5	0.9	-0.8	-0.1	0.7
Leg predicted mass (right)	0.9	4.7	22.8	1.4	2.3	2.0	3.9	4.8	0.6	-0.7	1.1	-0.9	-0.2	0.8
Arm fat mass (left)	0.5	2.1	5.8	1.1	2.4	1.6	2.3	2.1	0.0	0.2	1.6	-0.8	0.1	0.7
Number of self-reported non-cancer illnesses	0.8	1.4	3.5	-0.7	-0.6	-1.9	-0.8	-0.4	-1.8	-1.1	-0.9	-0.7	-1.6	-1.4
Average weekly champagne plus white wine intake	0.5	0.6	2.7	-0.3	-1.4	-0.1	-1.6	-0.7	-0.4	-0.6	-0.6	-0.7	-0.1	-0.6
Miserableness	0.4	0.7	2.2	0.4	-0.0	0.3	1.3	1.2	0.2	-0.8	0.1	-1.5	-1.1	-0.5
Guilty feelings	0.5	0.7	2.5	1.3	-1.6	-0.5	0.1	0.0	0.5	0.4	1.0	0.7	0.6	1.0
Wears glasses or contact lenses	1.8	2.1	7.3	0.7	-2.7	1.1	0.5	-1.4	0.6	1.6	1.2	1.0	1.9	1.8
Ever taken oral contraceptive pill	0.2	0.2	0.7	-0.8	0.2	-0.3	0.2	-0.7	0.2	0.2	0.2	0.3	-0.3	-0.4
Hearing aid user	0.8	0.9	2.5	0.9	0.5	0.3	1.4	0.8	1.3	0.6	0.6	1.6	0.7	0.9
Mother’s age at death	2.3	2.8	7.7	0.5	-1.2	-0.6	-1.6	-2.8	1.6	1.9	1.1	1.1	2.6	1.8
Financial situation satisfaction	0.7	0.8	2.6	0.2	-1.4	0.9	-0.2	0.5	-1.6	-0.9	-0.6	-1.3	-0.5	-0.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	4.5	0.8	-0.6	0.2	2.1	0.3	1.6	0.3	0.7	0.8	0.4	0.5
Commuting to job workplace: Public transport	1.2	1.4	4.2	-0.1	-1.5	-1.7	0.4	-1.2	0.5	1.1	0.1	2.0	1.4	0.9
Eye problems/disorders: Glaucoma	0.5	0.6	3.2	1.8	-0.3	-0.3	-0.5	0.1	1.1	-0.3	0.2	1.0	0.5	0.8
Medication: Blood pressure	0.2	0.5	2.7	-0.6	-0.1	-0.6	0.1	-0.4	-1.6	-0.4	-0.2	-0.2	-0.8	-0.8
Pain type(s) experienced in last month: Hip pain	0.7	0.8	3.8	1.9	0.5	0.6	-0.2	0.8	1.0	-1.4	-0.9	0.1	-0.2	0.3
Supplements: Fish oil (including cod liver oil)	1.3	1.7	7.1	-1.2	-1.1	-1.5	-1.9	-0.9	-2.7	-0.3	-1.0	-0.7	-0.7	-0.8
High cholesterol (Self-reported)	0.4	0.7	2.4	0.1	-0.8	-0.4	-0.7	0.4	-0.6	-1.4	-1.6	-0.1	-0.9	-0.6
Medication: Bendroflumethiazide	1.6	2.4	4.6	-2.1	-0.5	-1.4	-1.5	-0.5	-1.9	-1.1	-1.6	-2.0	-1.4	-1.7
Medication: Paracetamol	0.6	0.9	2.8	-1.4	0.0	0.8	-1.7	-0.1	-0.6	-0.5	-0.5	-0.8	-1.1	-1.0
Medication: Lisinopril	0.5	0.7	1.6	0.6	-1.3	1.1	0.0	-1.0	0.3	0.8	0.6	0.7	1.0	1.0
Medication: Atorvastatin	2.2	2.7	6.1	-1.9	-0.2	-0.0	-1.9	1.0	-1.3	-1.9	-1.9	-1.1	-2.3	-2.5
Illnesses of father: High blood pressure	1.0	1.2	6.3	-0.8	0.2	1.3	-0.0	0.4	-2.5	-0.8	-1.0	-0.5	-1.2	-1.0
Alcohol drinker status: Never	1.1	1.4	3.5	1.0	-0.7	0.8	0.6	-1.3	0.5	1.5	1.3	0.4	1.8	1.9
Ever smoked	0.3	0.5	1.7	0.8	0.7	0.1	0.8	1.0	-1.3	-0.3	0.4	0.7	-0.4	0.2
Basal metabolic rate	0.6	3.3	15.8	1.1	2.1	1.0	3.3	4.0	0.2	-0.6	0.9	-1.0	-0.3	0.5
Leg fat percentage (left)	0.2	0.7	3.7	0.7	1.9	0.5	1.1	0.3	-0.4	0.5	1.3	-0.4	0.1	0.4
Arm fat-free mass (left)	0.4	2.0	8.5	0.9	1.8	0.3	2.7	2.9	0.0	-0.4	0.8	-0.8	-0.2	0.5
Number of operations (self-reported)	0.7	1.1	3.2	0.3	-0.1	0.8	-0.4	1.7	-0.1	-1.8	-1.1	0.9	-1.4	-1.0
Average weekly beer plus cider intake	1.6	2.3	6.9	0.3	-0.8	0.3	0.0	2.6	-1.8	-2.5	-1.6	-0.4	-1.9	-1.2
Irritability	0.4	0.6	2.0	0.8	0.5	-0.3	1.4	-0.6	0.1	0.8	1.1	0.8	0.6	0.7
Risk taking	2.2	3.3	7.4	0.9	1.1	-0.2	1.8	-1.6	1.5	2.3	2.7	1.5	2.4	2.4
Ever had prostate specific antigen (PSA) test	1.2	1.4	6.0	-0.8	-2.5	-1.9	-1.0	-1.5	0.3	1.0	0.4	0.5	0.8	0.3
Fractured/broken bones in last 5 years	0.5	0.6	1.8	-1.4	-0.9	-0.7	-0.2	-1.1	-1.1	0.5	-0.5	0.8	-0.1	-0.3
Age started oral contraceptive pill	0.9	1.1	3.0	-1.6	-0.9	-1.7	-1.6	-1.0	-0.6	0.4	-1.1	0.1	0.0	-0.8
Diastolic blood pressure, automated reading	0.9	2.6	6.8	-1.1	0.7	1.2	1.2	2.6	-1.2	-1.6	-1.9	-1.4	-2.1	-1.9
Ever depressed for a whole week	1.6	2.0	5.9	-0.5	-1.1	-2.4	-1.1	-2.0	-0.6	2.0	1.2	-0.1	1.6	0.7
Unable to work because of sickness or disability	0.5	0.7	2.1	1.3	1.2	-0.1	1.4	0.2	1.1	-0.6	0.4	-0.3	-0.2	0.4
Commuting to job workplace: Cycle	1.9	2.3	5.2	-2.1	-2.3	-0.9	-1.5	-0.4	-1.5	-0.9	-1.8	-1.3	-1.3	-1.6
Myopia	1.5	2.2	5.9	0.9	-1.3	0.6	2.3	-0.3	0.7	1.6	1.6	2.4	1.4	1.5
Vascular/heart problems diagnosed by doctor	0.8	2.3	5.4	-0.6	-1.2	1.4	0.4	-1.9	0.9	2.3	1.9	2.1	1.5	1.3
Cholesterol lowering medication	0.3	0.4	1.0	-0.8	0.0	0.3	1.0	-0.8	-0.4	1.0	0.6	0.2	0.2	0.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	4.9	1.1	1.6	-0.0	-1.3	1.2	-0.3	-0.7	0.3	-2.2	-0.3	-0.2
Pain experienced in last month	1.3	2.2	3.8	0.8	-1.0	0.6	1.9	-1.7	-0.4	1.8	1.6	1.8	1.7	1.8
Supplements: Calcium	4.2	4.6	9.7	1.1	-2.6	-0.5	-0.4	-2.0	2.2	2.5	2.4	2.1	3.1	2.6
Basal cell carcinoma (self-reported)	1.3	1.5	6.4	0.2	-2.5	-1.8	-0.4	-0.8	1.4	0.5	0.2	1.8	0.9	0.3
Heart attack/myocardial infarction (self-reported)	0.8	1.1	5.2	2.3	-0.1	0.6	-0.8	0.3	1.2	0.1	0.9	0.8	1.1	1.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.9	1.0	0.3	-0.3	-0.3	0.2	-0.1	0.5	1.4	0.7	0.6	0.8
Heart disease (siblings)	1.0	1.2	4.1	0.5	2.0	-0.9	-0.6	1.6	-0.7	-0.7	-0.2	-1.9	-0.6	-0.4
Alcohol drinker status: Previous	0.8	0.9	2.4	0.3	0.9	1.0	0.5	1.3	-0.5	-1.1	-0.7	-0.8	-1.6	-1.0
Pack years of smoking	4.5	6.7	13.0	1.6	0.7	1.0	3.0	-2.0	1.3	3.6	3.5	2.3	3.4	3.5
Impedance of whole body	0.2	1.0	5.0	-1.1	-0.7	0.3	-1.5	-2.2	0.7	0.5	-0.3	0.3	0.2	-0.6
Leg fat mass (left)	0.5	2.0	8.2	1.1	2.9	1.0	1.9	2.2	-0.5	-0.5	1.0	-1.1	-0.5	0.2
Arm predicted mass (left)	0.4	2.1	9.3	0.9	1.8	0.4	2.8	3.0	-0.1	-0.4	0.8	-0.7	-0.2	0.5