TWAS hub - PLEKHB1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0840	0.0270	3.6e-07	0.063	0.050	0.038	0.051	0.049	3.6e-08	8.3e-07	1.6e-05	6.5e-07	1.3e-06
2	GTEx	Brain Frontal Cortex BA9	0.4153	0.1178	1.1e-03	0.165	NA	-0.004	NA	0.084	3.8e-05	NA	4.2e-01	NA	3.0e-03
3	GTEx	Heart Atrial Appendage	0.2660	0.0870	7.1e-06	0.118	NA	0.164	NA	0.180	6.1e-06	NA	7.7e-08	NA	1.6e-08
4	GTEx	Lung	0.1047	0.0355	7.1e-05	0.065	NA	0.041	NA	0.059	1.1e-05	NA	4.2e-04	NA	2.8e-05
5	GTEx	Skin Not Sun Exposed Suprapubic	0.2090	0.0820	3.2e-04	0.183	NA	0.111	NA	0.133	2.8e-10	NA	1.2e-06	NA	9.8e-08
6	GTEx	Testis	0.4390	0.0910	4.4e-09	0.179	NA	0.236	NA	0.241	2.3e-08	NA	7.6e-11	NA	4.7e-11
7	GTEx	Thyroid	0.1640	0.0570	2.0e-05	0.143	NA	0.118	NA	0.134	4.5e-11	NA	2.7e-09	NA	1.9e-10
8	METSIM	Adipose	0.0581	0.0223	4.2e-04	0.009	0.016	0.009	0.015	0.005	1.3e-02	1.6e-03	1.2e-02	2.1e-03	4.4e-02
9	ROSMAP	Brain Pre-frontal Cortex	0.1165	0.0432	3.5e-06	0.061	0.040	0.047	0.051	0.075	2.8e-08	5.8e-06	1.1e-06	3.1e-07	6.2e-10
10	TCGA	Breast Invasive Carcinoma	0.0300	0.0138	3.4e-05	0.032	0.027	0.024	NA	0.026	3.2e-07	2.3e-06	7.4e-06	NA	3.0e-06
11	TCGA	Colon Adenocarcinoma	0.0530	0.0310	9.8e-03	0.034	0.015	0.010	NA	0.023	4.7e-03	4.6e-02	8.2e-02	NA	1.6e-02
12	TCGA	Lung Adenocarcinoma	0.1202	0.0402	7.6e-09	0.100	0.085	0.098	NA	0.095	1.1e-11	3.7e-10	1.6e-11	NA	3.2e-11
13	TCGA	Lung Squamous Cell Carcinoma	0.0818	0.0298	2.0e-07	0.088	0.059	0.084	NA	0.084	3.3e-10	2.6e-07	9.0e-10	NA	8.0e-10
14	TCGA	Ovarian Serous Cystadenocarcinoma	0.0770	0.0320	2.4e-05	0.089	0.075	0.074	NA	0.088	1.2e-06	8.3e-06	1.1e-05	NA	1.5e-06
15	TCGA	Pancreatic Adenocarcinoma	0.1070	0.0520	2.0e-03	0.085	0.070	0.048	NA	0.079	2.0e-04	6.9e-04	4.3e-03	NA	3.3e-04
16	TCGA	Prostate Adenocarcinoma	0.2576	0.0556	0.0e+00	0.304	0.234	0.280	NA	0.298	2.9e-32	3.1e-24	2.2e-29	NA	1.7e-31
17	TCGA	Testicular Germ Cell Tumors	0.2290	0.0760	3.8e-05	0.062	0.112	0.104	NA	0.131	3.1e-03	9.2e-05	1.6e-04	NA	2.4e-05
18	TCGA	Thyroid Carcinoma	0.0620	0.0230	1.2e-06	0.040	0.066	0.069	NA	0.068	8.7e-05	4.8e-07	3.1e-07	NA	3.4e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Alzheimer’s Disease (in father)	6.2	6.7	12.5	-1.7	-0.9	-0.2	-3.2	-0.8	-3.3	-3.3	-0.9	-0.9	-3.1	-2.5	-3.5	-3.5	-3.4	-3.2	-3.3	-1.2	-2.8
Fluid intelligence score	4.4	9.2	17.7	1.1	1.1	-0.7	3.6	-1.0	4.2	3.8	2.9	1.0	3.1	3.3	4.0	3.9	3.8	3.7	3.8	0.2	3.3
Ulcerative Colitis	4.3	6.2	12.4	2.3	0.8	-0.4	3.0	-0.6	2.8	2.7	1.1	1.8	1.6	3.1	2.8	3.2	2.8	2.8	2.6	3.5	3.3
Verbal and Numeric Reasoning (VNR)	4.0	9.7	18.8	1.1	-0.1	-0.9	3.8	-2.4	4.3	3.9	3.9	-0.3	2.2	3.6	4.1	3.8	4.0	3.9	3.9	-0.0	2.9
Number of full brothers	3.7	4.6	10.1	0.6	1.2	1.2	-2.7	1.3	-3.2	-2.9	-1.3	0.6	-1.3	-2.7	-2.7	-2.7	-2.8	-2.9	-2.9	0.0	-1.8
Chronic bronchitis/emphysema (mother)	3.6	4.2	9.2	1.6	0.2	-0.5	2.6	-1.0	2.5	2.4	0.6	0.8	0.6	2.0	2.7	2.8	2.6	2.3	2.4	3.0	2.1
Fractured/broken bones in last 5 years	3.5	4.5	7.7	1.3	-1.2	1.5	2.4	1.0	2.7	2.4	2.0	1.6	2.2	2.6	2.4	2.6	2.8	2.4	2.3	1.4	2.0
Ever smoked	3.3	5.8	14.4	2.3	0.3	1.0	2.6	1.3	2.5	2.7	1.2	2.3	2.0	2.0	2.5	3.0	2.5	2.6	2.7	3.8	3.3
Intelligence (Savage-Jansen 2018)	3.0	9.2	18.1	1.0	-0.9	-0.9	3.7	-2.3	4.3	3.7	3.7	-0.3	2.0	3.7	3.8	3.6	3.9	3.8	3.7	-0.3	2.9
Vitamin and mineral supplements	3.0	4.1	7.9	1.8	1.3	1.3	1.9	0.3	2.5	1.8	2.8	2.1	2.6	2.3	1.6	2.1	2.0	1.9	1.8	2.0	2.7
Medication: Co-codamol	3.0	3.5	7.2	-2.1	-1.3	0.2	-1.9	0.6	-2.3	-2.3	-1.1	-0.8	-1.8	-1.2	-2.6	-2.7	-2.3	-2.0	-2.2	-1.5	-2.2
Glaucoma (self-reported)	2.7	3.1	9.4	2.6	2.1	1.6	1.1	2.1	1.5	0.9	1.5	3.1	2.5	1.6	1.0	1.4	1.2	1.0	0.9	1.1	2.4
Tinnitus: Yes, now most or all of the time	2.6	3.1	6.4	-0.2	1.5	0.2	-2.2	1.5	-1.9	-2.4	-0.9	1.1	-0.9	-1.9	-2.5	-2.1	-2.5	-2.3	-2.4	0.3	-1.0
Type 2 Diabetes (T2D) (2018)	2.4	4.5	10.1	-0.0	-1.3	-0.2	2.7	-0.6	2.6	3.1	0.9	-1.6	1.7	1.5	3.2	2.8	3.0	2.8	3.1	-0.5	0.5
Past tobacco smoking	2.4	4.3	11.9	-0.8	0.6	-0.5	-2.5	-0.9	-2.5	-2.6	-1.3	-1.6	-1.5	-1.5	-2.2	-2.6	-2.1	-2.5	-2.6	-3.4	-2.6
Alzheimer’s Disease (including proxy)	2.3	3.3	6.2	-1.0	1.2	-0.4	-2.4	0.0	-2.1	-2.1	-2.1	0.1	-2.1	-2.5	-2.1	-2.1	-2.4	-2.3	-2.2	0.5	-1.5
Mean time to correctly identify matches	2.3	4.4	8.1	-1.2	-0.1	1.1	-2.4	0.7	-2.6	-2.6	-1.2	-1.7	-1.6	-2.3	-2.7	-2.8	-2.3	-2.6	-2.5	-1.8	-2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.9	8.7	-1.0	-0.2	-0.0	-3.0	0.9	-2.6	-2.7	-2.2	-0.2	-2.0	-2.5	-2.6	-2.7	-2.7	-2.7	-2.7	-1.8	-2.8
Medication: Atorvastatin	2.3	2.8	9.4	2.7	1.1	2.1	1.0	1.7	1.3	1.2	0.8	3.1	2.2	0.6	1.3	1.9	1.2	1.1	1.1	1.6	2.0
Unable to work because of sickness or disability	2.3	3.0	9.2	2.5	0.9	2.2	1.6	2.8	1.0	1.1	-0.4	2.3	3.0	1.6	1.0	1.3	1.2	1.3	1.1	0.8	2.3
Worrier / anxious feelings	2.2	4.2	11.0	3.0	2.5	2.3	-1.9	3.1	-2.0	-2.1	-0.8	3.3	-0.3	-1.7	-1.7	-1.1	-1.6	-2.1	-2.1	1.9	0.1
Neck or shoulder pain in last month	2.2	3.1	15.9	2.5	1.1	2.5	0.6	4.0	0.4	0.5	-1.0	2.9	2.6	1.0	0.6	1.0	0.9	0.6	0.5	1.3	1.8
Medication: Gliclazide	2.2	2.5	5.3	1.9	-1.4	2.3	1.5	0.5	1.3	1.5	2.0	1.1	1.3	1.1	1.8	1.9	2.0	1.4	1.5	1.5	1.2
Medication for cholesterol, blood pressure or diabetes	2.1	3.5	8.0	-2.8	-1.6	-1.8	-1.7	-2.8	-0.9	-1.4	0.9	-2.3	-2.4	-0.9	-1.2	-1.9	-1.2	-1.4	-1.4	-2.4	-2.4
Smoking status: Previous	2.1	3.2	6.7	0.3	-1.3	0.5	2.3	0.3	2.4	2.3	1.9	1.2	1.0	1.4	1.9	2.1	1.9	2.2	2.2	2.6	1.8
Eye problems/disorders: Glaucoma	2.1	2.5	10.8	2.3	1.5	2.4	0.5	2.8	0.5	0.0	1.0	3.3	2.1	1.1	0.0	0.5	0.4	0.3	0.0	1.5	1.8
Major Depression (MDD)	2.0	2.4	13.1	1.1	3.6	0.0	-0.7	2.5	-0.4	-0.1	-2.7	2.0	0.8	-1.2	0.4	0.5	-0.5	-0.4	-0.1	2.8	1.0
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	9.0	2.7	1.4	3.0	1.0	3.0	1.0	0.7	0.2	2.5	2.8	1.2	1.0	1.3	1.5	0.8	0.7	1.3	2.1
Diabetes (mother)	1.9	2.4	4.5	-1.4	-2.0	-1.6	1.8	-1.1	1.4	2.1	0.6	-1.9	0.8	1.6	1.8	1.5	1.6	2.1	2.1	-0.9	0.3
Average weekly fortified wine intake	1.8	2.1	4.1	1.2	1.3	0.2	1.4	1.7	1.3	1.7	-1.3	0.7	2.0	0.6	1.8	1.9	1.5	1.5	1.7	0.8	1.6
Migraine (self-reported)	1.8	2.3	6.4	-0.6	0.1	-2.0	1.6	-2.5	1.9	1.8	1.2	-1.2	-0.1	1.4	1.8	1.5	1.5	1.8	1.8	0.2	0.9
Ovarian Cancer	1.7	2.3	5.0	-0.6	-0.3	0.8	-2.2	-0.7	-1.3	-2.1	0.7	0.3	-1.4	-1.3	-2.2	-2.2	-1.9	-2.0	-2.1	0.0	-1.6
Neuroticism	1.7	4.0	13.2	3.2	2.6	1.8	-1.7	2.9	-1.7	-2.0	-1.3	3.6	-0.4	-1.1	-1.6	-0.9	-1.5	-1.9	-2.0	2.3	0.4
Maternal smoking around birth	1.7	2.4	6.0	1.6	2.5	0.2	1.0	1.8	1.5	1.2	-1.9	2.0	1.9	0.4	1.6	1.8	1.1	1.1	1.2	1.8	1.8
Asthma (self-reported)	1.7	3.4	14.6	2.5	1.3	1.5	1.1	1.1	1.6	0.9	1.7	3.2	1.2	1.6	0.9	1.4	1.1	1.0	0.8	3.8	2.7
Hand grip strength (left)	1.6	4.1	11.6	-2.3	0.1	-2.5	-1.7	-1.3	-2.2	-1.6	-3.4	-2.8	-2.0	-2.3	-1.6	-2.0	-2.0	-1.8	-1.6	-1.4	-2.0
Nervous feelings	1.6	2.9	12.3	3.2	2.2	3.1	-1.1	1.9	-0.9	-1.2	1.0	3.5	1.1	-0.4	-1.0	-0.4	-0.7	-1.1	-1.2	1.1	0.7
Hair/balding pattern: Pattern 3	1.6	2.4	4.7	1.0	-0.2	0.0	2.0	0.3	1.8	2.2	1.0	0.6	1.6	1.3	1.9	2.1	1.7	2.1	2.2	0.5	1.9
Asthma	1.6	3.3	14.4	2.5	1.1	1.5	1.0	1.2	1.5	0.8	1.6	3.2	1.1	1.5	0.9	1.4	1.1	1.0	0.8	3.8	2.7
Medication: Cholesterol lowering	1.6	2.6	6.1	2.0	0.8	1.2	1.7	2.3	1.1	1.7	-0.6	1.4	2.5	0.9	1.5	1.9	1.4	1.6	1.7	1.3	1.9
Ever taken oral contraceptive pill	1.6	1.8	9.8	-2.0	-0.2	-2.5	0.5	-3.1	0.7	0.6	1.1	-2.3	-1.1	0.4	0.4	0.0	0.2	0.5	0.6	-1.2	-0.7
Depression (Nagel 2018)	1.5	2.2	10.3	2.3	1.2	2.8	-0.0	3.2	0.1	-0.0	-0.8	2.8	1.8	0.4	0.3	0.6	0.7	0.0	-0.0	0.7	1.0
Worry (Nagel 2018)	1.5	3.2	14.2	3.2	2.1	3.0	-0.8	2.7	-0.7	-1.0	0.7	3.8	1.0	-0.4	-0.8	-0.2	-0.5	-1.0	-1.1	2.1	0.8
Ever had hysterectomy (womb removed)	1.5	1.7	3.9	-0.7	-1.8	1.0	-1.2	0.9	-1.8	-1.3	-1.0	-0.7	-1.1	-1.5	-1.6	-1.4	-1.4	-1.3	-1.3	0.0	-2.0
Medication: Ramipril	1.5	1.9	3.5	1.0	1.0	0.0	1.8	0.4	1.7	1.7	-0.9	0.2	1.6	0.9	1.7	1.8	1.6	1.5	1.7	1.1	1.9
Falls in the last year	1.5	2.1	4.2	1.3	1.1	0.6	1.5	1.1	1.5	1.5	-0.5	1.0	2.0	1.4	1.7	1.8	1.7	1.5	1.5	0.8	1.9
Had major operations	1.5	1.7	4.8	0.9	0.5	-0.0	1.5	1.1	1.0	1.6	-0.2	1.1	2.2	1.2	1.6	1.7	1.3	1.6	1.6	0.0	1.9
Cholesterol lowering medication	1.5	2.1	4.5	0.7	-1.7	-0.2	2.1	-0.4	1.5	1.9	1.5	0.1	1.0	1.8	1.8	1.7	1.8	1.9	1.8	0.2	1.4
Serious illness, injury or assault to yourself	1.4	1.7	4.4	-0.1	-1.1	-0.1	-1.2	0.5	-2.1	-1.6	-1.5	-0.3	-1.3	-1.0	-1.7	-1.7	-1.7	-1.4	-1.6	-1.4	-1.3
Multivitamins +/- minerals	1.4	1.8	6.8	-2.0	-1.0	-2.0	-0.4	-1.8	-0.7	-0.1	-1.0	-2.6	-1.9	-1.0	-0.1	-0.6	-0.5	-0.3	-0.1	-1.7	-1.9
High blood pressure (mother)	1.4	1.9	3.9	-0.0	-1.4	1.3	-1.5	0.3	-1.8	-1.6	-0.4	-0.2	-1.1	-2.0	-1.6	-1.6	-1.6	-1.7	-1.6	-0.7	-1.8
Peak expiratory flow (PEF)	1.4	3.3	9.3	-3.0	-0.8	-1.0	-2.1	0.2	-2.0	-1.8	-3.0	-1.1	-1.5	-1.9	-1.7	-2.0	-2.0	-1.9	-1.8	-0.8	-1.8
Exposure to tobacco smoke outside home	1.4	1.9	6.4	2.4	1.1	0.6	1.1	1.7	0.8	0.7	-0.3	2.5	1.3	0.9	0.6	1.1	0.6	0.8	0.7	1.7	2.5
Medication: Paracetamol	1.4	2.2	13.8	1.7	0.3	3.1	0.4	3.7	-0.3	0.1	-1.9	1.5	2.5	0.5	0.2	0.4	0.7	0.2	0.1	0.0	1.0
Ulcerative Colitis (UC)	1.3	2.5	6.9	2.3	0.7	-0.1	1.8	-0.3	1.3	1.5	-0.4	1.4	1.3	2.2	1.7	2.0	1.8	1.7	1.5	1.1	2.6
Breast Cancer	1.3	3.2	5.9	-2.4	-2.2	-0.7	-1.4	-0.5	-1.8	-1.8	-1.6	-2.4	-1.4	-1.1	-2.1	-2.4	-1.8	-1.7	-1.8	-1.9	-1.9
Bipolar Disorder (2011)	1.3	1.2	5.6	-1.2	-0.2	-1.4	-0.7	-0.5	-1.1	-0.6	-2.4	-2.1	-0.9	-0.8	-0.6	-1.0	-0.8	-0.6	-0.5	0.0	-1.5
Hand grip strength (right)	1.3	3.6	6.9	-2.6	-0.3	-2.2	-1.7	-1.2	-2.0	-1.8	-2.4	-2.4	-2.1	-1.8	-1.6	-2.1	-1.8	-1.8	-1.7	-1.3	-1.9
Mouth/teeth dental problems	1.3	2.0	4.0	-1.5	-1.4	-0.8	-1.4	-1.0	-1.7	-1.3	0.3	-1.5	-1.9	-1.1	-1.4	-1.6	-1.4	-1.3	-1.3	-2.0	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	9.1	-1.8	-0.5	-0.6	-2.5	1.0	-2.4	-2.0	-2.6	-0.9	-1.6	-2.2	-1.8	-2.2	-2.1	-2.1	-2.0	-2.5	-3.0
Headache pain in last month	1.3	2.3	4.8	0.7	0.3	0.0	1.8	0.9	1.4	1.9	-0.6	-0.1	2.0	1.9	2.1	1.9	2.2	1.9	1.9	-0.0	1.6
Medication: Blood pressure	1.3	2.3	6.8	2.6	1.6	1.5	1.1	2.2	0.6	1.0	-1.3	2.0	1.3	0.0	0.7	1.3	0.6	0.8	1.0	2.6	1.9
Diabetes diagnosed by doctor	1.3	2.1	4.5	0.6	-0.4	-0.3	1.9	-0.6	1.7	2.1	0.7	-1.4	1.1	1.3	2.1	1.8	2.1	2.0	2.1	-0.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.8	-1.7	-1.9	-1.9	1.2	-1.0	0.8	1.4	0.2	-1.5	-0.2	0.7	1.2	0.9	0.8	1.3	1.4	-0.5	0.5
Osteoporosis (self-reported)	1.3	1.7	6.3	2.5	2.0	2.0	-0.4	1.6	-0.1	-0.2	-1.8	2.2	0.6	-0.4	-0.1	0.3	-0.0	-0.2	-0.2	1.8	0.9
Schizophrenia (2018)	1.2	2.5	6.8	1.6	2.1	0.7	-1.8	2.6	-1.7	-1.7	-2.0	1.0	0.1	-1.7	-1.5	-1.3	-1.7	-1.8	-1.7	-0.2	-1.0
Reaction Time	1.2	2.3	4.3	-1.4	0.1	0.1	-1.8	-0.4	-1.7	-1.9	-1.1	-1.6	-1.4	-1.4	-1.9	-2.1	-1.6	-1.8	-1.9	-1.4	-1.8
Worry too long after embarrassment	1.2	2.1	4.3	-0.1	0.6	0.4	-1.9	0.2	-2.0	-1.7	-1.1	0.2	-1.5	-2.1	-1.7	-1.6	-1.8	-1.8	-1.7	0.0	-1.7
Leg pain on walking	1.2	1.5	3.0	0.1	-0.5	0.3	-1.5	-0.6	-1.6	-1.7	1.4	0.2	-1.5	-0.7	-1.7	-1.6	-1.4	-1.5	-1.7	0.1	-0.6
Mood swings	1.2	2.2	8.6	0.8	0.1	1.1	-1.4	2.9	-1.9	-1.7	-1.7	2.1	-0.4	-0.8	-1.8	-1.2	-1.5	-1.5	-1.7	1.0	-0.2
Neuroticism (Nagel 2018)	1.1	2.6	9.9	2.9	1.4	2.4	-1.2	2.8	-1.2	-1.4	-0.4	3.1	0.4	-0.4	-1.2	-0.6	-0.8	-1.3	-1.5	1.4	0.2
Neuroticism (2016)	1.1	1.5	7.5	2.3	1.1	1.8	-0.6	2.7	-0.7	-0.8	0.0	2.4	0.6	0.0	-0.7	-0.2	-0.4	-0.6	-0.8	1.1	-0.0
Medication for hormone replacement therapy	1.1	1.3	5.4	1.7	2.3	0.8	0.1	1.9	0.5	0.0	-0.6	2.2	1.4	0.6	0.0	0.4	0.1	0.2	0.0	0.7	1.3
Number of incorrect matches in round	1.1	1.8	4.0	-0.2	-0.4	0.9	-1.5	1.2	-2.0	-1.8	-1.1	0.3	-1.0	-1.4	-1.6	-1.6	-1.4	-1.8	-1.8	-0.4	-1.7
Hair/balding pattern: Pattern 2	1.1	1.5	4.5	-2.1	-1.5	0.4	-1.0	-0.9	-1.0	-1.1	-0.7	-1.9	-1.6	-0.7	-1.1	-1.4	-0.6	-1.0	-1.0	0.1	-1.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.5	1.3	1.9	-1.1	1.1	0.0	1.4	1.1	1.7	1.0	0.8	1.3	1.0	1.1	0.9	1.2	1.1	0.9	1.7
Alcohol intake versus 10 years previously	1.1	1.6	3.9	-0.0	-0.3	-0.3	-1.5	-0.5	-2.0	-1.4	-0.5	-1.0	-1.9	-1.2	-1.3	-1.5	-1.3	-1.4	-1.4	-1.0	-1.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	6.2	-1.8	-0.7	-0.2	-2.5	1.5	-2.4	-2.1	-2.5	-0.6	-1.3	-1.9	-1.9	-2.2	-2.0	-2.1	-2.1	-2.0	-2.5
Number of children fathered	1.1	1.2	5.1	-0.0	2.1	1.5	-1.1	2.3	-0.5	-0.8	-0.7	0.8	0.8	-1.4	-0.9	-0.7	-0.8	-1.0	-0.8	0.2	-0.5
Shortness of breath walking on level ground	1.1	1.3	2.6	1.1	0.8	-0.4	1.4	-0.1	1.3	1.3	1.2	0.2	1.4	1.6	1.1	1.4	1.3	1.4	1.3	0.1	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	4.5	-0.5	-0.5	-1.1	-0.9	-1.6	-1.3	-1.1	0.3	-1.4	-2.1	-0.9	-1.3	-1.4	-1.3	-1.1	-1.1	0.1	-1.2
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.2	1.0	1.0	1.4	-1.1	1.8	-1.1	-1.1	-0.8	1.7	-0.3	-1.4	-1.0	-0.7	-1.1	-1.2	-1.1	1.2	-0.2
Pain experienced in last month	1.1	1.8	8.6	-1.3	-0.3	-2.1	1.2	-2.9	1.6	1.3	1.8	-1.3	-0.8	0.6	1.2	1.0	0.9	1.2	1.3	0.4	-0.1
HbA1C	1.0	1.1	2.3	0.9	-1.1	0.3	1.1	-1.1	1.2	1.3	1.4	0.0	0.6	1.1	1.4	1.1	1.5	1.2	1.2	-0.2	0.2
Frequency of depressed mood in last 2 weeks	1.0	1.4	6.8	2.1	1.6	2.3	-0.7	1.6	-0.3	-0.5	0.2	2.6	0.7	-0.3	-0.2	0.2	-0.0	-0.5	-0.5	1.4	0.5
Ever used hormone-replacement therapy (HRT)	1.0	1.3	6.8	1.6	0.8	1.6	0.8	2.6	0.1	0.6	-1.0	1.2	2.0	0.5	0.4	0.6	0.4	0.6	0.6	0.2	1.2
Medication: Metformin	1.0	1.4	2.5	0.6	-0.7	-0.1	1.5	-1.1	1.5	1.4	1.3	-1.0	1.0	1.6	1.4	1.2	1.6	1.5	1.5	0.1	0.6
Medication: Atenolol	1.0	1.2	8.2	1.3	1.3	1.1	0.6	2.9	0.1	0.2	-0.6	1.0	2.3	0.4	0.2	0.4	0.2	0.3	0.3	0.1	1.2
Qualifications: None of the above	1.0	2.1	9.2	0.3	0.3	1.4	-1.3	3.0	-1.3	-1.5	-1.6	1.8	0.1	-1.1	-1.8	-1.1	-1.5	-1.5	-1.5	1.6	-0.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.4	0.2	-1.1	0.4	1.3	0.8	1.3	1.5	0.7	0.4	0.7	0.9	1.2	1.4	1.4	1.4	1.5	1.3	0.9
Qualifications: nursing, teaching	1.0	1.6	4.4	-1.3	-1.4	-0.7	1.3	-2.1	1.0	1.4	1.5	-1.8	-0.0	0.9	1.4	0.9	1.3	1.3	1.4	-1.2	-0.0
Illnesses of father: None of the above (group 1)	1.0	1.3	2.6	0.5	0.3	0.1	1.4	-0.4	1.5	1.5	1.5	0.5	1.0	0.9	1.6	1.5	1.4	1.4	1.4	0.4	0.8
High cholesterol (Self-reported)	1.0	1.7	3.5	0.7	-0.5	-0.2	1.9	0.6	0.9	1.8	-0.1	0.2	1.7	1.4	1.6	1.8	1.5	1.8	1.8	0.0	1.7
Alcohol drinker status: Never	1.0	1.2	2.4	1.1	0.3	1.5	-1.2	0.5	-0.9	-1.4	0.9	0.8	-0.5	-0.9	-1.6	-1.3	-1.3	-1.3	-1.4	-0.3	-1.3
Number of operations (self-reported)	1.0	1.4	3.0	-0.3	-0.6	-0.5	1.5	0.4	1.3	1.7	0.2	-0.3	1.2	1.5	1.7	1.4	1.6	1.7	1.7	-0.5	0.9
Myopia	1.0	1.5	4.4	-0.9	0.8	-1.4	-1.3	-1.6	-1.0	-0.9	-0.9	-1.6	-2.1	-1.2	-0.9	-1.1	-1.1	-1.0	-0.9	-0.6	-1.4
Heart disease (siblings)	1.0	1.3	6.3	-1.3	-2.5	-0.6	-0.4	-0.2	-1.0	-0.5	-1.5	-2.2	-0.9	-0.3	-0.7	-0.9	-0.6	-0.5	-0.5	-0.9	-1.5
Bipolar Disorder or Schizophrenia	0.9	2.3	3.9	1.0	1.2	0.1	-2.0	1.5	-1.8	-1.9	-1.7	0.6	-1.1	-1.7	-1.5	-1.5	-1.7	-1.9	-1.9	0.0	-1.6
Fasting Glucose	0.9	1.0	4.7	-1.7	-2.2	-1.3	0.0	-1.7	-0.4	-0.2	-0.2	-1.9	-0.8	-0.2	-0.5	-0.2	-0.5	-0.1	-0.2	-0.7	-0.8
Schizophrenia (2014)	0.9	2.0	5.6	2.1	2.0	1.2	-1.3	2.3	-1.0	-1.3	-0.6	2.4	0.2	-1.5	-1.0	-0.7	-1.3	-1.4	-1.3	1.4	-0.2
Smoking Status	0.9	2.0	8.2	1.0	0.9	0.3	1.4	1.6	0.9	1.5	-0.8	1.7	1.3	0.4	1.1	1.6	0.8	1.3	1.5	2.9	2.3
Lung FEV1/FVC ratio	0.9	4.4	27.9	-3.0	1.6	-0.7	-2.3	2.1	-2.2	-1.6	-5.3	0.0	-0.4	-2.2	-1.7	-1.6	-2.2	-1.7	-1.6	-1.0	-1.1
Hearing difficulty/problems: Yes	0.9	1.3	4.5	-0.9	-2.1	-0.8	1.5	-0.8	0.9	1.4	-0.3	-1.1	0.2	1.3	1.3	1.0	1.3	1.5	1.4	0.4	0.7
Taking other prescription medications	0.9	1.4	8.2	2.9	2.1	1.6	0.0	1.6	0.0	0.0	-0.2	2.0	1.1	-0.1	0.1	0.5	0.1	-0.0	0.0	1.3	1.0
Diabetes (self-reported)	0.9	1.4	3.8	-0.1	-1.1	-0.5	1.3	-1.5	1.3	1.5	0.7	-2.0	0.2	0.9	1.5	1.1	1.5	1.4	1.5	-0.8	-0.3
Neuroticism score	0.9	2.0	4.7	1.9	1.3	1.2	-1.4	2.1	-1.6	-1.6	-1.0	2.2	-0.6	-1.0	-1.4	-0.9	-1.2	-1.5	-1.6	1.4	-0.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.5	0.9	-0.1	-0.6	1.2	-1.4	1.2	1.6	0.5	-0.0	0.1	0.7	1.6	1.6	1.3	1.4	1.5	0.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	3.9	-1.5	0.8	-2.0	-1.0	-1.2	-0.7	-0.6	-1.5	-1.0	-1.7	-1.3	-0.6	-0.8	-1.1	-0.8	-0.6	-0.1	-0.8
Wheeze or whistling in the chest in last year	0.9	1.6	8.2	2.9	1.9	1.8	0.1	1.4	0.2	0.1	-0.8	2.2	1.1	-0.1	0.0	0.5	0.0	0.1	0.1	1.7	1.2
Emphysema/chronic bronchitis	0.9	1.0	5.9	2.4	1.3	1.8	-0.1	0.5	-0.1	0.0	0.5	1.8	0.6	-0.7	0.2	0.5	0.0	-0.1	-0.0	1.6	0.6
Pulse rate, automated reading	0.9	2.8	10.6	2.1	0.6	0.2	1.4	-0.2	1.5	1.3	2.4	2.4	0.4	1.4	1.3	1.8	1.3	1.3	1.2	3.3	2.5
Breast cancer (self-reported)	0.9	1.1	6.7	1.3	-1.1	2.6	0.1	1.4	0.2	-0.2	1.1	1.8	0.7	0.1	-0.1	0.3	0.4	-0.2	-0.2	1.6	0.4
Financial situation satisfaction	0.9	1.1	3.4	1.5	0.8	1.4	0.3	1.8	0.3	0.4	-0.4	1.6	1.1	0.6	0.7	0.9	0.9	0.4	0.4	1.8	1.1
Age at First Birth	0.8	1.2	3.6	0.5	0.7	0.2	0.9	1.5	1.1	1.2	0.7	0.7	1.9	1.4	1.2	1.2	1.2	1.3	1.2	-0.5	1.1
Number of treatments/medications taken	0.8	1.4	4.3	2.1	1.1	1.1	0.8	1.9	0.6	0.8	-0.9	1.6	1.0	0.5	0.8	1.1	0.8	0.7	0.8	1.6	1.5
Sensitivity / hurt feelings	0.8	1.4	3.2	1.2	1.8	0.6	-1.5	1.7	-1.3	-1.4	-0.8	0.9	-0.2	-1.1	-1.3	-1.1	-1.3	-1.3	-1.4	0.1	-0.8
Supplements: Zinc	0.8	0.9	2.4	-1.5	-0.4	0.2	-1.0	-0.6	-1.0	-0.8	0.1	-0.7	-1.6	-1.4	-0.9	-1.0	-1.0	-0.9	-0.8	-0.0	-1.3
Current tobacco smoking	0.8	1.3	5.9	0.6	1.4	0.3	-1.0	1.3	-1.3	-0.7	-2.4	0.5	-0.5	-1.6	-1.0	-0.5	-1.2	-0.8	-0.7	1.6	0.1
Chronic bronchitis/emphysema (father)	0.8	0.9	3.5	-0.6	-1.9	0.4	-0.7	-0.3	-1.1	-0.4	0.2	-1.7	-0.8	-1.1	-0.7	-0.7	-0.6	-0.5	-0.4	-1.5	-1.6
Hearing difficulty/problems with background noise	0.8	1.3	6.3	0.2	-2.2	-0.1	0.9	-1.6	0.9	0.7	2.5	0.4	-0.7	1.0	0.8	0.6	0.9	0.8	0.7	1.7	0.7
Financial difficulties in last 2 years	0.8	1.0	2.0	-0.2	-0.8	0.1	1.1	0.4	1.0	1.2	-0.3	0.5	0.5	1.4	1.2	1.2	1.4	1.3	1.2	1.4	1.2
Pain all over the body in last month	0.8	0.9	6.8	1.0	0.1	2.6	-0.3	2.1	-0.3	-0.1	-0.0	1.4	1.2	-0.2	0.2	0.3	0.5	-0.2	-0.1	-0.3	-0.2
High blood pressure (siblings)	0.8	1.2	6.4	0.9	-0.8	-0.2	1.2	-1.1	1.0	1.0	1.5	0.7	-0.5	0.4	0.8	1.1	0.7	1.0	1.0	2.5	1.1
Medication: Ibuprofen	0.8	0.9	2.8	0.7	1.3	1.1	0.5	1.6	0.3	0.4	-0.4	1.4	1.7	1.0	0.5	0.7	0.7	0.5	0.4	0.1	1.6
Family relationship satisfaction	0.8	1.0	5.9	1.5	0.4	1.4	-0.5	1.5	-0.5	-0.8	0.6	2.4	0.5	0.0	-0.4	-0.1	-0.3	-0.7	-0.8	1.4	0.4
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.4	-0.1	-0.9	0.4	-1.2	0.7	-1.6	-1.1	-1.1	0.4	-1.1	-1.1	-1.2	-1.1	-1.2	-1.1	-1.1	0.6	-0.7
Medication: Lisinopril	0.8	1.0	3.4	1.7	-0.1	1.9	-0.7	1.1	-1.1	-0.7	-0.5	1.4	-0.3	-1.2	-0.7	-0.4	-0.7	-0.8	-0.7	1.6	-0.4
Basal cell carcinoma (self-reported)	0.8	1.0	2.2	-0.7	-0.0	1.0	-1.2	-0.6	-1.1	-1.1	0.1	-0.7	-1.2	-1.5	-1.1	-1.2	-1.0	-1.2	-1.1	0.0	-1.5
Depressed Affect (Nagel 2018)	0.7	1.5	5.9	1.9	0.8	1.5	-0.8	2.4	-0.9	-1.1	-1.4	2.4	0.3	0.1	-0.8	-0.5	-0.5	-0.9	-1.1	1.2	0.5
Alzheimer’s Disease (in mother)	0.7	0.8	5.1	0.1	2.3	0.0	-0.4	1.0	0.1	-0.1	-1.5	1.4	0.3	-0.8	0.1	0.2	-0.4	-0.3	-0.1	1.6	0.9
Allergy or Eczema	0.7	1.8	4.2	1.2	0.1	-0.1	1.7	0.1	1.6	1.7	0.7	0.5	1.2	2.1	1.6	1.5	1.7	1.8	1.7	-0.1	1.7
Average weekly spirits intake	0.7	0.9	3.9	0.6	1.0	1.1	0.6	1.2	0.7	0.5	-0.3	2.0	1.2	0.3	0.5	0.8	0.4	0.5	0.5	1.7	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.6	1.6	0.7	1.3	0.2	2.2	0.4	0.1	-0.8	1.9	1.1	0.7	0.3	0.6	0.6	0.2	0.1	0.4	1.2
Stomach or abdominal pain in last month	0.7	0.8	1.6	-0.4	0.3	-1.0	0.9	-0.7	1.0	1.1	-0.9	-1.2	0.6	0.6	1.3	0.9	1.0	1.0	1.2	-1.2	0.2
Alcohol usually taken with meals	0.7	1.1	2.0	-0.2	-1.1	0.2	1.2	0.5	1.2	1.3	1.1	0.1	0.8	1.3	1.3	1.3	1.4	1.3	1.3	0.3	0.9
Pulse rate	0.7	1.1	7.7	0.7	0.8	-0.5	-0.6	-1.1	-0.3	-0.8	2.8	1.6	-1.0	0.4	-1.0	-0.7	-0.9	-0.6	-0.9	0.9	0.7
Illnesses of mother	0.7	0.9	2.8	0.3	0.3	-0.5	0.9	0.8	0.8	0.7	0.6	0.1	1.4	1.7	0.9	0.7	1.0	0.9	0.7	-1.7	1.1
Hair/balding pattern: Pattern 4	0.7	1.7	3.7	0.9	0.7	-0.3	1.3	1.2	1.5	1.5	0.6	1.6	1.9	1.1	1.2	1.7	1.0	1.4	1.4	0.7	1.9
Pulse wave reflection index	0.7	0.8	4.7	-1.0	0.0	-0.9	-0.6	-2.2	-0.1	-0.6	0.9	-1.3	-1.3	-0.8	-0.4	-0.7	-0.6	-0.6	-0.5	-0.2	-1.2
Loud music exposure frequency	0.7	0.8	2.9	-0.2	-1.1	-1.0	1.0	-0.7	0.6	1.1	-0.6	-0.0	-0.5	0.5	1.0	1.1	0.9	1.0	1.1	1.7	0.4
Gout (self-reported)	0.7	1.0	5.4	2.3	0.4	1.2	-0.0	1.8	-0.5	-0.5	0.2	1.6	0.2	0.6	-0.8	-0.3	-0.3	-0.3	-0.5	1.5	1.0
Age at first live birth	0.7	1.2	4.0	-2.0	-1.7	-1.2	0.4	-1.3	0.5	0.8	-0.1	-1.8	-0.3	0.5	1.0	0.4	0.8	0.7	0.8	-1.8	-0.6
Health satisfaction	0.7	0.9	3.7	1.6	0.8	1.0	-0.9	1.0	-0.6	-1.1	1.3	1.9	-0.1	-0.0	-0.9	-0.6	-0.7	-0.9	-1.1	-0.3	0.2
Qualifications: College or University degree	0.7	2.2	16.6	-1.7	-0.9	-1.5	0.7	-4.1	1.4	1.1	1.9	-1.6	-0.9	0.7	1.3	0.9	1.2	1.0	1.1	-0.5	-0.3
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-0.1	-0.5	0.2	-1.0	0.1	-1.2	-1.0	-0.1	-0.2	-1.3	-1.3	-0.9	-1.0	-1.0	-1.1	-1.0	-0.3	-1.1
Comparative height size at age 10	0.7	3.7	7.3	0.5	-1.9	-0.9	2.7	-0.9	2.2	2.5	0.8	-1.0	1.3	2.3	2.7	2.4	2.7	2.5	2.5	-0.7	1.3
Average weekly red wine intake	0.7	1.0	2.2	-0.5	-0.9	-0.8	1.2	-1.3	1.5	1.1	0.8	-1.1	0.3	1.2	1.1	0.9	1.2	1.1	1.1	-0.6	0.2
Back pain experienced in last month	0.7	1.0	6.7	-0.4	-0.4	-0.2	-0.8	0.5	-1.3	-0.9	-2.6	-0.6	-0.3	-0.9	-1.2	-1.1	-1.1	-0.9	-0.9	-0.6	-0.1
Wears glasses or contact lenses	0.7	0.8	2.2	0.9	-0.5	1.1	0.8	0.6	0.6	0.8	0.9	0.9	1.5	0.7	0.7	0.9	0.8	0.8	0.8	0.5	1.2
Mother’s age at death	0.7	0.9	1.9	-0.6	-0.5	1.1	-1.1	-1.1	-0.8	-1.0	1.2	-0.1	-0.8	-1.0	-1.4	-1.1	-1.1	-1.0	-1.0	-0.0	-1.2
Ever had prostate specific antigen (PSA) test	0.7	0.8	3.1	-1.3	-0.7	0.5	-0.8	-0.9	-0.4	-0.6	1.0	-1.3	-1.0	-1.1	-0.7	-0.9	-0.6	-0.7	-0.6	0.1	-1.8
Commuting to job workplace: Cycle	0.7	0.8	4.0	-0.5	-0.8	0.0	0.5	-2.0	1.1	0.3	2.0	0.5	-0.4	0.9	0.4	0.3	0.6	0.4	0.3	1.4	0.4
Alcohol drinker status: Previous	0.7	0.8	2.2	-1.4	0.5	-1.3	-0.8	-0.1	-0.6	-0.7	0.2	-1.2	-0.8	-0.6	-0.7	-0.9	-0.8	-0.7	-0.7	-1.5	-1.3
Coronary Artery Disease (CAD)	0.6	0.7	2.3	1.5	1.3	0.5	0.1	1.2	-0.1	0.0	-1.5	1.4	0.7	-0.2	-0.0	0.2	-0.2	0.0	0.0	0.0	1.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	0.9	-0.5	-0.5	1.2	1.1	0.6	1.0	-0.2	0.7	0.5	1.1	0.9	1.0	0.7	1.0	1.0	0.0	1.0
Blood Platelet Count	0.6	6.6	11.5	-0.2	2.5	0.8	-3.2	-0.8	-3.2	-3.2	-1.9	0.8	-2.3	-3.3	-3.2	-3.0	-3.4	-3.3	-3.2	-0.4	-2.6
Chronotype (morning person)	0.6	1.3	4.3	-2.1	0.3	-0.5	-1.1	-0.2	-1.0	-1.0	-1.4	-1.4	-0.5	-1.1	-1.0	-1.4	-1.0	-1.1	-1.0	-1.7	-1.3
Relative age of first facial hair	0.6	1.2	3.8	0.8	0.8	1.2	-1.2	2.0	-1.5	-1.0	-1.6	0.9	0.1	-1.5	-0.9	-0.9	-1.1	-1.2	-1.0	-0.3	-0.1
Diabetes (father)	0.6	0.7	3.5	-1.3	-1.9	-0.6	0.4	-1.0	0.7	0.4	0.5	-1.2	-0.9	0.8	0.4	0.1	0.7	0.4	0.4	-0.2	-1.1
Pack years adult smoking proportion	0.6	0.9	2.1	0.5	-0.0	-0.5	1.5	-0.5	1.0	1.3	-0.6	-0.1	0.9	0.9	1.5	1.3	1.2	1.2	1.3	-0.2	0.6
Qualifications: CSEs or equivalent	0.6	0.9	3.2	0.3	1.7	-1.2	-0.7	0.9	-0.9	-0.9	-1.8	0.0	0.1	0.1	-0.9	-0.9	-0.9	-0.7	-0.9	-1.1	0.1
Had menopause	0.6	0.7	5.2	0.3	-2.3	1.3	0.7	0.6	0.2	0.4	1.4	0.1	0.6	0.8	0.6	0.4	0.9	0.4	0.4	-0.3	0.1
Medication: Simvastatin	0.6	0.9	2.6	0.4	-1.1	-0.9	1.6	-0.2	0.8	1.4	-0.0	-0.8	0.2	0.9	1.2	1.2	1.1	1.3	1.4	0.2	0.6
Impedance of arm (right)	0.6	2.6	8.0	1.3	0.2	2.3	1.1	0.6	1.9	1.2	2.8	2.3	1.8	1.5	1.3	1.7	1.7	1.3	1.2	1.3	1.6
Time employed in main current job	0.6	0.7	3.3	-0.5	-1.8	-0.1	-0.2	-1.7	0.0	-0.2	1.1	-0.9	-1.4	-0.1	-0.2	-0.4	-0.0	-0.2	-0.3	0.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.6	2.1	1.0	1.7	-0.4	2.1	-0.3	-0.3	-0.9	1.6	1.1	0.4	0.1	0.3	0.4	-0.2	-0.3	-0.1	0.4
Happiness	0.6	0.8	1.8	1.1	0.5	-0.7	1.0	0.4	0.7	0.9	-0.5	0.8	0.8	0.9	1.2	1.3	1.1	0.9	0.9	0.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.7	0.2	0.7	0.5	0.7	1.4	0.3	0.5	-0.4	0.8	1.6	1.3	0.5	0.7	0.7	0.7	0.5	-0.7	1.6
Impedance of arm (left)	0.6	2.6	8.5	1.8	0.4	2.5	0.9	0.9	1.6	1.0	2.9	2.4	1.8	1.5	1.2	1.6	1.6	1.1	1.0	1.0	1.6
Breastfed as a baby	0.6	0.7	6.5	-0.4	-0.6	-0.2	0.5	0.4	-0.2	0.4	-1.0	-1.6	0.8	0.2	0.4	0.1	0.4	0.4	0.4	-2.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.4	1.2	1.6	0.9	-1.0	1.5	-1.1	-0.8	-0.2	1.4	-0.1	-1.1	-0.8	-0.5	-0.9	-0.9	-0.8	0.5	0.0
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.9	-1.3	-0.2	-0.1	-1.0	-0.6	-0.9	-1.0	0.8	-0.5	-1.1	-0.9	-1.2	-1.4	-1.2	-1.0	-1.0	-0.9	-0.9
Medication: Paracetamol	0.6	1.0	6.0	1.2	0.3	1.6	0.2	2.5	-0.4	-0.1	-1.9	0.7	1.4	0.6	-0.1	0.1	0.4	0.0	-0.1	-0.1	0.8
Arm predicted mass (right)	0.6	3.0	13.1	-2.7	-2.4	-2.4	-0.2	-2.0	-1.2	-0.2	-1.6	-3.6	-1.5	-0.5	-0.3	-1.0	-0.5	-0.3	-0.2	-2.6	-1.7
Suffer from ‘nerves’	0.6	1.0	4.4	2.1	1.5	1.1	-0.2	1.8	-0.6	-0.3	-0.8	1.9	0.5	-0.3	-0.3	0.1	-0.3	-0.3	-0.4	0.7	0.8
Overall health rating	0.6	1.3	5.5	2.3	1.5	1.1	-0.4	2.3	-0.4	-0.4	-1.4	1.9	0.8	-0.3	-0.2	0.2	-0.2	-0.4	-0.4	1.1	0.8
Smoking status: Current	0.6	1.0	5.5	0.5	1.4	-0.1	-0.8	0.9	-1.1	-0.5	-2.3	0.4	-0.4	-1.2	-0.8	-0.4	-1.1	-0.6	-0.5	1.5	0.3
Number of self-reported non-cancer illnesses	0.6	1.1	4.8	1.6	-0.3	-0.3	1.1	-0.4	0.9	0.8	1.1	1.0	-0.3	1.4	0.5	0.8	0.7	0.9	0.8	2.2	1.4
Miserableness	0.6	1.1	4.1	2.0	0.8	1.3	-0.7	1.8	-0.8	-0.8	-1.8	1.7	0.5	0.0	-0.6	-0.3	-0.4	-0.7	-0.8	-0.3	0.5
Guilty feelings	0.6	0.9	2.8	1.6	0.7	0.4	-0.7	0.8	-1.0	-1.0	-0.9	1.3	-1.1	-0.4	-0.8	-0.4	-0.6	-1.0	-1.1	1.7	0.1
Illnesses of father: High blood pressure	0.6	0.8	4.7	1.0	2.2	-0.2	-0.4	-0.0	0.1	-0.3	-1.1	0.8	-0.1	-0.5	-0.3	-0.1	-0.5	-0.4	-0.3	2.1	0.7
Arm fat-free mass (left)	0.6	2.8	11.3	-2.8	-2.8	-2.2	-0.2	-1.8	-1.3	-0.2	-1.6	-3.4	-1.6	-0.6	-0.4	-1.0	-0.6	-0.3	-0.2	-2.0	-1.6
Primary Biliary Cirrhosis	0.5	0.7	1.7	1.2	1.3	-0.5	-0.6	-0.6	-0.1	-1.0	1.2	1.2	-0.8	0.0	-0.7	-0.5	-0.7	-0.8	-1.0	0.7	0.3
Respiratory disease	0.5	1.2	4.8	2.1	0.9	1.0	0.4	0.4	0.6	0.2	0.8	2.2	0.4	0.7	0.4	0.7	0.4	0.3	0.2	2.2	1.5
Lung FVC	0.5	2.8	17.4	1.3	-0.3	2.6	-1.5	4.2	-1.6	-1.4	-1.0	1.5	0.2	-1.8	-1.4	-1.1	-1.4	-1.5	-1.4	0.0	-1.4
Angina	0.5	0.6	4.0	0.8	0.1	1.4	-0.5	2.0	-0.2	-0.4	-0.2	1.6	0.3	-0.1	-0.2	0.0	-0.1	-0.3	-0.4	1.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	5.5	2.3	0.7	1.4	-0.4	0.9	-0.1	-0.5	0.1	1.9	-0.0	0.4	-0.0	0.1	0.3	-0.4	-0.6	1.1	0.4
Allergy	0.5	1.2	2.7	-1.4	0.2	-0.9	-1.0	-0.1	-1.1	-1.1	-1.0	-1.2	-0.7	-1.1	-1.1	-1.2	-1.2	-1.1	-1.1	-1.6	-1.6
Trunk fat-free mass	0.5	2.9	13.0	-2.5	-2.8	-2.1	-0.1	-2.2	-1.0	-0.1	-1.4	-3.6	-1.5	-0.5	-0.2	-0.9	-0.3	-0.1	-0.0	-2.5	-1.7
Qualifications: A levels/AS levels or equivalent	0.5	1.2	4.9	-1.7	-0.9	-1.3	0.8	-2.2	1.1	0.9	1.4	-1.4	-0.5	0.6	1.0	0.6	0.9	0.9	0.9	-0.8	0.1
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	5.7	-0.1	2.4	-0.8	0.2	-0.4	1.1	0.3	0.3	0.1	0.6	0.7	0.4	0.3	0.2	0.4	0.4	0.1	0.4
Pulse wave Arterial Stiffness index	0.5	0.6	5.0	0.1	0.2	-0.9	0.3	-1.9	0.4	0.2	2.2	-0.3	-0.6	0.1	0.0	0.0	-0.1	0.2	0.2	-0.3	-0.0
Trunk predicted mass	0.5	2.8	12.9	-2.5	-2.8	-2.0	-0.0	-2.2	-1.0	-0.0	-1.4	-3.6	-1.4	-0.4	-0.2	-0.9	-0.3	-0.1	-0.0	-2.5	-1.7
Birth weight	0.5	1.1	3.4	0.2	-0.7	-0.1	-1.1	0.6	-1.7	-1.3	-1.8	-0.0	-1.3	-0.7	-1.2	-1.2	-1.1	-1.2	-1.3	-0.5	-0.7
Arm fat-free mass (right)	0.5	2.6	11.8	-2.6	-2.1	-2.4	-0.1	-2.0	-1.1	-0.1	-1.3	-3.4	-1.4	-0.4	-0.2	-0.9	-0.4	-0.2	-0.1	-2.4	-1.5
Pulse wave peak to peak time	0.5	0.6	6.2	-0.2	-0.1	0.8	-0.4	1.7	-0.5	-0.3	-2.5	0.1	0.5	-0.3	-0.1	-0.1	-0.0	-0.3	-0.3	0.1	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.8	4.6	-1.0	0.2	-1.4	-0.2	-2.1	0.6	-0.0	1.7	-0.5	-0.9	-0.6	0.1	-0.2	-0.3	-0.2	-0.1	-0.6	-1.1
Angina (self-reported)	0.5	0.7	3.5	1.1	0.1	1.6	-0.2	1.9	0.1	-0.2	0.1	1.8	0.4	0.1	-0.0	0.3	0.2	-0.1	-0.2	1.3	0.6
Medication: Omeprazole	0.5	0.7	2.3	0.2	-0.7	0.1	0.9	-0.5	0.9	0.9	1.5	-0.2	0.0	1.1	0.8	0.8	1.0	1.0	0.9	0.4	0.8
Heart disease (mother)	0.5	0.6	2.8	0.3	-1.1	0.7	-0.4	-1.5	0.0	-0.5	1.2	-0.0	-1.7	-0.3	-0.5	-0.4	-0.3	-0.4	-0.5	1.2	-0.7
Number of full sisters	0.5	0.7	4.4	0.8	0.8	-0.0	-0.4	1.2	-0.7	-0.4	-2.1	1.0	-0.3	-0.4	-0.5	-0.3	-0.6	-0.4	-0.4	1.2	0.5
Whole body fat-free mass	0.5	3.0	13.6	-2.8	-2.8	-2.1	-0.2	-2.1	-1.1	-0.1	-1.2	-3.7	-1.4	-0.4	-0.3	-1.0	-0.4	-0.2	-0.1	-2.5	-1.8
Leg fat-free mass (right)	0.5	2.7	12.2	-2.9	-2.9	-2.0	-0.0	-1.9	-0.8	-0.0	-0.5	-3.5	-1.1	-0.1	-0.1	-0.8	-0.1	-0.0	0.0	-2.4	-1.5
Friendships satisfaction	0.5	0.6	4.3	0.5	0.3	0.4	-0.6	0.6	-0.5	-0.7	0.3	1.8	-0.2	-0.4	-0.7	-0.3	-0.8	-0.6	-0.7	2.1	0.3
Commuting to job workplace: Walk	0.5	0.5	2.1	0.4	-0.4	-0.0	0.8	-1.5	0.7	0.4	1.3	0.3	0.5	1.0	0.6	0.5	0.7	0.5	0.4	-0.1	0.8
Whole body water mass	0.5	3.0	12.7	-2.8	-2.8	-2.0	-0.3	-1.9	-1.2	-0.3	-1.3	-3.6	-1.4	-0.5	-0.4	-1.1	-0.5	-0.3	-0.2	-2.6	-1.8
Leg predicted mass (right)	0.5	2.7	12.2	-2.9	-2.9	-2.1	-0.1	-1.9	-0.8	-0.0	-0.5	-3.5	-1.2	-0.0	-0.1	-0.8	-0.1	-0.0	0.0	-2.4	-1.5
Commuting to job workplace: Public transport	0.5	0.6	2.9	-1.7	-1.4	-0.8	0.2	-1.1	0.1	0.3	0.1	-1.7	-0.7	0.2	0.1	-0.1	0.3	0.3	0.3	-0.1	-0.7
Basal metabolic rate	0.5	2.6	11.6	-2.8	-2.9	-2.0	-0.0	-2.0	-0.9	0.0	-1.1	-3.4	-1.2	-0.3	-0.1	-0.8	-0.3	-0.0	0.1	-2.2	-1.5
Risk taking	0.5	0.7	2.2	-1.4	-1.5	-0.7	-0.3	-1.1	-0.6	-0.5	-0.7	-0.9	-1.5	-0.2	-0.6	-0.7	-0.4	-0.5	-0.6	-0.1	-0.4
Supplements: Calcium	0.5	0.6	2.2	0.5	-0.3	0.4	-1.0	-0.2	-0.8	-1.0	-0.1	0.3	-1.5	-0.7	-0.8	-0.8	-0.6	-1.0	-1.1	0.3	-0.8
Arm predicted mass (left)	0.5	2.7	10.5	-2.7	-2.5	-2.3	-0.2	-2.0	-1.2	-0.3	-1.5	-3.2	-1.7	-0.6	-0.4	-1.0	-0.6	-0.3	-0.2	-1.9	-1.5
Bipolar Disorder (2018)	0.4	0.6	2.3	-0.3	-0.6	-0.6	-0.9	-0.9	-0.6	-0.9	-0.5	-0.4	-1.5	-0.5	-0.6	-0.8	-0.6	-0.9	-0.9	-0.3	-1.3
Crohns Disease (2017)	0.4	0.9	2.0	-0.6	-1.3	-0.1	-0.9	-0.8	-1.3	-0.9	-1.1	-0.5	-1.4	-0.9	-0.8	-0.9	-0.8	-1.0	-1.0	-0.5	-1.0
Irritable Bowel Disease (IBD)	0.4	0.9	2.7	1.4	-0.5	0.2	1.1	-0.4	0.5	0.8	-0.5	0.9	0.5	1.5	1.0	1.2	1.2	0.9	0.8	0.8	1.6
Mean Putamen Volume	0.4	0.4	1.4	-0.6	0.2	-1.1	0.6	0.2	0.3	0.8	-1.2	-0.5	-0.2	-0.2	0.9	0.7	0.5	0.6	0.8	0.4	0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	4.0	1.1	-0.5	1.0	0.1	2.0	-0.6	-0.0	-1.3	0.9	0.6	0.1	-0.1	0.1	0.1	0.0	-0.0	-0.1	0.4
Impedance of leg (right)	0.4	1.9	8.0	2.0	2.1	1.6	0.5	0.6	1.1	0.6	0.8	2.8	1.3	0.6	0.7	1.2	0.7	0.6	0.6	2.0	1.9
Leg fat-free mass (left)	0.4	2.2	10.0	-2.7	-2.7	-1.7	-0.1	-1.6	-0.8	-0.1	-0.4	-3.2	-0.9	-0.1	-0.2	-0.8	-0.2	-0.1	-0.0	-2.3	-1.4
Townsend deprivation index at recruitment	0.4	0.6	3.4	1.3	1.0	0.2	0.1	1.8	-0.3	-0.0	-0.8	1.2	0.7	0.3	-0.1	0.2	-0.1	0.1	-0.0	0.7	1.0
Relative age voice broke	0.4	0.6	3.1	-0.3	0.7	0.8	-0.7	1.3	-1.1	-0.4	-1.8	-0.4	0.5	-0.9	-0.5	-0.5	-0.5	-0.5	-0.4	-0.7	-0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	3.9	-0.6	-2.0	0.7	0.2	0.0	-0.5	0.3	-0.3	-1.0	0.1	-0.2	0.1	0.1	0.2	0.2	0.2	-1.0	-1.0
High blood pressure	0.4	1.1	3.1	1.6	1.8	0.2	1.3	1.4	0.5	1.0	-1.4	0.1	1.6	0.2	0.7	0.9	0.5	0.9	1.0	0.3	1.1
Supplements: Glucosamine	0.4	0.5	2.7	-1.7	-0.3	-1.3	0.1	-0.2	0.2	0.3	-1.5	-1.0	-0.5	-0.4	0.2	0.1	-0.0	0.1	0.3	-0.4	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.2	0.2	-0.5	-0.6	0.9	-0.1	0.9	0.7	1.0	0.2	0.6	1.1	0.5	0.5	0.5	0.8	0.7	-0.6	0.5
Leg predicted mass (left)	0.4	2.2	9.7	-2.7	-2.8	-1.6	-0.2	-1.5	-0.8	-0.1	-0.4	-3.1	-1.0	-0.2	-0.2	-0.9	-0.3	-0.1	-0.1	-2.3	-1.5
Heart attack	0.4	0.6	2.2	1.2	0.9	0.7	-0.4	1.5	-0.3	-0.3	-1.5	1.3	0.3	-0.6	-0.3	0.0	-0.4	-0.3	-0.3	0.6	0.2
Illnesses of siblings	0.4	0.6	5.3	-0.9	1.1	-0.1	-0.3	0.6	-0.0	-0.2	-0.8	-0.2	1.2	0.2	-0.1	-0.3	-0.0	-0.2	-0.2	-2.3	-0.1
Hip circumference	0.4	1.9	9.0	-3.0	-3.0	-0.7	-0.4	-1.3	-1.1	-0.2	-0.1	-2.5	-1.2	-0.9	-0.5	-0.8	-0.5	-0.3	-0.2	-0.9	-1.6
Noisy workplace	0.4	0.4	1.5	-0.1	-0.8	-1.1	-0.2	-1.2	-0.4	-0.3	-0.5	-0.7	-1.2	-0.1	-0.6	-0.7	-0.7	-0.3	-0.3	0.6	0.2
Prospective memory result	0.4	0.5	1.6	-0.1	-1.0	-0.7	-0.4	-0.5	-0.7	-0.3	0.6	-1.0	-1.2	-0.5	-0.3	-0.4	-0.4	-0.3	-0.3	-0.7	-1.3
Length of working week for main job	0.4	0.5	3.3	-1.8	-1.5	0.9	-0.2	-0.0	-0.5	-0.1	-0.2	-0.8	0.1	-0.2	-0.2	-0.4	0.1	-0.1	-0.1	-1.0	-0.5
Birth weight of first child	0.4	0.8	10.1	-0.5	-0.3	-0.6	-0.1	0.4	-0.5	0.0	-3.2	-1.1	-0.3	-0.7	-0.1	-0.1	-0.2	-0.1	0.0	-1.0	-0.5
Eye problems/disorders: None of the above	0.4	0.5	2.0	-1.2	0.1	-0.8	-0.4	-1.2	-0.2	-0.1	-0.6	-1.4	-0.3	-0.5	-0.1	-0.3	-0.2	-0.1	-0.1	-1.2	-0.3
Medication: Allopurinol	0.4	0.5	1.8	1.2	0.3	0.9	-0.4	1.3	-0.7	-0.8	0.3	0.8	0.0	0.2	-1.0	-0.7	-0.5	-0.6	-0.8	0.6	0.5
Age at last live birth	0.4	0.6	1.4	-0.2	-0.8	0.0	0.8	0.7	0.7	1.0	-0.6	-0.1	1.0	0.4	1.2	0.9	1.0	0.9	1.0	-0.9	0.3
Hypertension (Self-reported)	0.4	1.2	3.2	1.8	1.4	0.5	1.4	1.5	0.6	1.0	-1.1	0.3	1.6	0.4	0.7	0.9	0.6	1.0	1.0	0.7	1.3
Loneliness, isolation	0.4	0.6	2.4	1.4	0.4	-0.2	-0.1	0.7	-0.4	-0.4	-1.1	1.5	-0.6	0.3	-0.1	0.1	-0.1	-0.3	-0.5	1.5	0.7
Long-standing illness, disability or infirmity	0.4	0.5	2.5	1.6	0.0	0.5	0.7	0.5	0.5	0.7	0.1	0.9	0.0	0.6	0.6	0.9	0.6	0.7	0.7	1.3	0.7
Eye problems/disorders: Cataract	0.4	0.4	4.4	-0.3	-2.1	0.5	0.6	0.4	0.2	0.3	0.5	-0.5	-0.0	0.9	0.1	0.0	0.5	0.5	0.3	0.1	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.0	-0.9	-0.7	-1.4	0.1	-1.2	-0.1	0.3	-0.9	-1.0	-1.3	-0.2	0.3	0.2	0.1	0.2	0.3	0.7	0.1
Average weekly champagne plus white wine intake	0.4	0.6	1.0	-0.6	-0.4	0.1	0.7	-0.7	1.0	1.0	0.9	-0.1	0.6	1.0	1.0	0.7	1.0	1.0	1.0	-0.2	0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	0.6	0.3	-0.8	0.9	-0.5	1.0	0.9	0.2	0.2	0.0	0.7	0.8	0.9	0.7	0.9	0.9	0.7	0.7
Medication: Bendroflumethiazide	0.4	0.6	2.9	1.3	0.9	0.5	0.3	1.6	-0.0	0.2	-1.1	0.7	0.5	-0.8	-0.0	0.3	-0.3	0.0	0.2	1.7	0.0
Age started oral contraceptive pill	0.4	0.5	1.6	-0.9	-0.1	0.1	-0.5	-1.1	-0.5	-0.5	0.1	-1.2	-0.5	-0.7	-0.4	-0.6	-0.4	-0.5	-0.5	-1.3	-1.3
Ever depressed for a whole week	0.4	0.5	3.4	0.8	1.5	-0.6	-0.1	0.2	0.1	-0.1	0.0	1.2	-0.6	-0.4	-0.2	0.2	-0.5	-0.2	-0.1	1.8	0.7
Pack years of smoking	0.4	0.5	1.5	0.4	-0.2	-0.2	1.2	-0.1	0.7	1.0	-0.9	-0.2	0.8	0.6	1.1	1.0	0.9	0.9	1.0	-0.4	0.2
Impedance of whole body	0.4	2.2	5.8	1.5	1.0	1.9	0.9	0.6	1.6	1.1	2.0	2.4	1.6	1.2	1.2	1.6	1.5	1.1	1.0	1.4	1.8
BMI	0.3	2.0	8.9	-3.0	-2.2	-2.1	-0.4	-1.8	-1.1	-0.3	-0.3	-2.4	-1.7	-0.5	-0.5	-0.9	-0.7	-0.4	-0.3	-0.5	-1.2
Waist Hip Ratio (WHR)	0.3	1.4	4.2	1.5	1.2	-0.2	1.2	0.1	1.2	1.1	0.2	1.2	1.4	1.7	1.2	1.3	1.1	1.3	1.1	0.5	2.0
Hypothyroidism (self reported)	0.3	0.6	2.7	-0.9	-0.4	-0.9	-0.9	-1.1	-0.2	-0.5	-0.2	-0.2	-1.6	-1.0	-0.5	-0.4	-0.6	-0.6	-0.5	0.6	-1.0
Systolic blood pressure, automated reading	0.3	1.0	3.8	0.1	-1.3	-0.4	1.2	-1.5	0.8	0.8	1.1	-1.9	-0.2	1.1	0.7	0.2	0.9	0.9	0.8	-1.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.3	1.2	0.7	-0.7	0.6	0.3	0.6	0.5	0.1	0.8	-0.1	0.3	0.7	0.7	0.4	0.5	0.5	0.9	0.5
Medication: Levothyroxine sodium	0.3	0.6	3.6	1.4	0.3	0.0	-0.4	0.1	-0.2	-0.3	-0.6	1.3	-1.0	-0.9	-0.3	0.1	-0.4	-0.5	-0.3	1.9	0.4
Impedance of leg (left)	0.3	1.4	5.5	1.5	1.9	1.0	0.5	0.1	0.9	0.6	0.6	2.4	0.9	0.5	0.8	1.2	0.7	0.6	0.6	1.9	1.8
Trunk fat mass	0.3	1.2	8.1	-2.3	-2.9	-0.4	0.6	-1.0	0.2	0.8	0.5	-1.6	-0.2	0.3	0.6	0.4	0.7	0.8	0.9	-0.1	-0.4
Weight	0.3	1.5	9.2	-2.4	-3.0	-1.1	0.3	-1.4	-0.5	0.4	-0.2	-2.4	-0.8	-0.1	0.2	-0.2	0.2	0.3	0.4	-0.8	-0.9
Father’s age at death	0.3	0.5	1.7	-0.6	-0.3	-0.1	-0.7	-1.3	-0.6	-0.3	1.2	-0.6	-0.8	-0.6	-0.4	-0.5	-0.5	-0.4	-0.4	-0.7	-0.9
Number of live births	0.3	0.4	0.9	0.4	0.3	-0.2	-0.4	0.9	-0.9	-0.6	-0.9	0.5	-0.2	-0.6	-0.7	-0.7	-0.9	-0.6	-0.6	-0.2	-0.1
Mouth/teeth dental problems: Dentures	0.3	0.5	6.9	0.1	0.1	1.0	0.2	0.4	0.7	-0.0	-0.2	0.8	0.2	0.0	0.2	0.2	0.3	-0.1	-0.0	2.6	0.3
Depression (self-reported)	0.3	0.4	1.1	1.0	1.0	0.9	-0.6	1.0	-0.3	-0.6	-0.1	0.9	0.4	-0.4	-0.4	-0.2	-0.3	-0.6	-0.6	0.3	-0.2
Lung cancer (father)	0.3	0.4	1.6	0.2	-1.3	0.2	0.8	-0.3	0.4	0.7	0.9	-0.2	0.3	0.7	0.5	0.6	0.6	0.8	0.7	-0.5	0.2
Arm fat mass (right)	0.3	1.2	8.5	-2.4	-2.9	-1.0	0.4	-1.1	-0.2	0.5	-0.1	-1.8	-0.6	0.1	0.2	-0.0	0.2	0.5	0.5	-0.2	-0.6
Exposure to tobacco smoke at home	0.3	0.3	2.1	0.6	-1.4	1.1	-0.0	-0.7	-0.0	-0.3	0.7	0.3	-0.5	-0.0	-0.6	-0.4	-0.3	-0.2	-0.3	0.5	0.2
Tense / ‘highly strung’	0.3	0.5	2.6	1.6	-0.2	0.9	0.2	0.8	0.0	0.2	1.1	1.2	0.4	0.1	0.4	0.6	0.4	0.2	0.2	0.0	0.1
Blood clot in the leg (DVT)	0.3	0.4	1.8	-0.4	-0.6	0.1	0.7	0.7	0.1	0.7	-1.3	-0.3	0.7	0.5	0.6	0.7	0.6	0.7	0.8	-0.3	0.5
Medication: Amlodipine	0.3	0.4	1.8	0.6	0.5	0.6	0.4	1.3	0.1	0.6	-1.2	0.3	0.9	-0.1	0.3	0.6	0.3	0.4	0.6	0.7	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.9	0.6	-0.8	0.9	-0.2	0.4	0.2	0.1	-0.1	1.4	-0.4	-0.1	0.4	0.5	0.4	0.0	0.0	1.2	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	2.0	0.2	0.3	0.1	0.4	0.0	0.5	0.3	0.6	1.2	0.1	-0.1	0.1	0.4	0.0	0.2	0.3	1.4	0.9
Medication: Aspirin	0.3	0.4	1.4	1.0	-0.9	1.1	0.5	1.0	0.0	0.4	0.2	0.6	0.4	0.3	0.2	0.5	0.4	0.4	0.4	1.2	0.7
Illnesses of father: Heart disease	0.3	0.4	1.1	-0.1	-1.0	0.0	-0.3	1.1	-1.0	-0.8	-0.5	-0.4	-0.3	0.5	-0.9	-0.9	-0.5	-0.5	-0.8	-0.6	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	4.8	-0.8	-0.5	-1.4	-0.3	-2.2	-0.2	-0.1	0.8	-1.3	-1.2	-0.1	-0.1	-0.4	-0.2	-0.1	-0.1	-0.5	-0.4
Ever had bowel cancer screening	0.3	0.4	2.7	0.1	-0.3	-0.0	-0.4	0.1	-0.5	-0.6	-0.9	-0.6	-0.3	0.1	-0.3	-0.8	-0.3	-0.5	-0.6	-1.6	-0.9
Osteoarthritis (self-reported)	0.3	0.4	1.2	-0.2	-0.3	0.0	0.6	-0.1	0.7	0.8	0.9	0.6	0.0	0.3	0.7	0.9	0.6	0.7	0.8	1.1	0.4
Hearing aid user	0.3	0.3	1.4	-0.7	-0.3	-0.7	0.2	-1.2	0.6	0.3	-1.1	-0.7	-0.4	0.2	0.1	0.1	0.1	0.3	0.3	0.5	0.0
Irritability	0.3	0.5	2.7	1.4	0.2	1.4	0.2	1.6	-0.0	0.0	-0.2	0.8	0.7	0.4	-0.0	0.2	0.4	0.1	0.0	0.0	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.9	-1.4	-1.3	0.2	-1.3	-1.0	-0.7	-1.0	1.3	-0.0	-1.2	-0.4	-0.8	-0.9	-0.5	-1.0	-1.1	-0.6	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.2	1.1	0.9	0.4	-0.0	1.3	0.1	0.1	-1.5	1.1	0.5	-0.2	0.1	0.4	-0.0	0.1	0.1	0.5	0.5
Schizophrenia vs Biploar Disorder	0.2	0.3	1.1	0.3	0.4	1.1	-0.4	1.0	-0.2	-0.2	-0.1	0.8	0.7	-0.8	-0.2	-0.1	-0.3	-0.3	-0.2	0.4	-0.0
Prostate Cancer	0.2	0.3	1.2	0.2	-0.0	-1.0	0.4	-0.8	0.0	0.4	-1.1	-0.9	-0.5	-0.0	0.5	0.3	0.3	0.3	0.4	-0.9	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	1.7	-0.5	-1.3	-0.7	0.1	-0.8	-0.4	-0.2	-0.0	-0.7	-0.4	0.5	-0.3	-0.4	-0.2	-0.1	-0.2	0.0	0.1
Crohns Disease (2012)	0.2	0.3	1.0	-0.3	-0.0	-0.3	-0.5	-0.3	-0.6	-0.5	-0.5	0.2	-1.0	-0.9	-0.5	-0.5	-0.7	-0.6	-0.6	0.5	-0.4
HDL Cholesterol	0.2	0.3	3.4	-0.3	0.0	0.2	0.0	0.4	0.1	-0.0	0.1	-0.8	0.8	0.3	0.2	-0.1	0.4	-0.0	-0.0	-1.9	-0.4
LDL Cholesterol	0.2	0.3	2.5	0.2	0.1	-0.5	0.2	-1.6	0.5	0.4	0.7	-0.6	0.1	0.5	0.5	0.4	0.5	0.4	0.4	0.2	0.3
Lupus	0.2	0.3	0.7	-0.5	-0.8	0.2	0.4	0.1	0.5	0.6	0.8	-0.1	0.6	0.4	0.6	0.5	0.7	0.6	0.6	-0.2	0.7
Triglycerides	0.2	0.4	1.2	-0.6	-0.2	-0.3	-0.6	-1.1	-0.6	-0.7	-0.3	-0.5	-0.8	-0.3	-0.9	-0.8	-0.7	-0.6	-0.7	-0.1	-0.6
Systolic Blood Pressure	0.2	0.8	2.7	0.9	0.8	-1.3	-0.2	-1.6	-0.3	-0.5	-0.0	-1.6	-1.6	-0.5	-0.5	-0.8	-0.6	-0.5	-0.5	-0.4	-0.9
Severe depression (siblings)	0.2	0.3	2.0	0.2	0.1	-0.7	-0.1	-0.9	0.3	-0.0	0.1	-0.0	-1.4	-0.5	-0.0	0.1	-0.1	-0.2	-0.1	0.9	-0.1
Trunk fat percentage	0.2	0.9	6.1	-1.8	-2.5	0.2	0.8	-0.5	0.5	1.0	0.8	-0.7	0.3	0.6	0.7	0.6	0.8	0.9	1.0	0.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.9	-0.4	-0.6	-0.2	0.2	-0.3	-0.1	0.3	-0.6	-1.0	0.4	0.5	0.1	-0.1	0.1	0.3	0.3	-0.9	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.2	0.6	-0.3	-0.2	0.7	-0.9	0.9	0.8	1.1	-0.1	0.1	0.8	0.7	0.6	0.8	0.8	0.8	-0.1	0.7
Sitting height	0.2	1.2	5.1	-1.5	-2.3	-1.1	0.7	-1.6	0.2	0.7	0.4	-2.1	-0.2	0.9	0.7	0.3	0.8	0.8	0.7	-1.4	-0.3
Body mass index (BMI)	0.2	0.8	4.8	-1.9	-2.2	-0.8	-0.2	-0.6	-0.7	-0.1	-0.6	-1.4	-1.0	-0.5	-0.4	-0.5	-0.4	-0.1	-0.1	0.2	-0.8
Had other major operations	0.2	0.3	1.6	0.6	-0.2	0.3	0.2	1.0	0.3	0.1	-0.7	0.8	-0.3	0.2	0.1	0.3	0.3	0.1	0.1	1.3	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	2.5	-0.6	0.1	-1.6	-0.1	-0.0	-0.7	-0.1	-0.2	0.0	-0.7	-0.3	-0.4	-0.2	-0.6	-0.1	-0.1	0.5	0.1
Arm fat percentage (right)	0.2	0.9	7.4	-2.2	-2.7	-0.3	0.3	-0.6	-0.0	0.5	0.1	-1.2	-0.3	0.0	0.1	0.0	0.1	0.4	0.5	0.3	-0.5
Standing height	0.2	1.8	6.7	-1.4	-2.4	-0.9	0.7	-2.4	0.2	0.9	0.7	-2.6	-0.3	0.6	1.1	0.4	1.1	0.8	0.9	-2.3	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	2.5	0.7	0.0	-0.1	0.2	0.1	0.6	0.4	-0.1	1.0	-0.3	-0.1	0.4	0.8	0.4	0.3	0.4	1.6	0.6
Forced vital capacity (FVC), Best measure	0.2	0.9	3.1	-0.5	-0.8	-0.3	-1.1	0.5	-1.0	-0.8	-0.8	-0.8	-0.9	-1.0	-0.6	-0.9	-0.7	-0.9	-0.8	-1.5	-1.8
Body fat percentage	0.2	0.7	5.2	-1.8	-2.3	-0.0	0.6	-0.5	0.3	0.8	0.4	-0.8	0.1	0.2	0.6	0.5	0.6	0.7	0.8	0.6	0.0
Comparative body size at age 10	0.2	0.5	3.0	-1.2	-0.1	-0.7	0.3	-0.8	0.2	0.4	-1.0	-1.7	0.2	0.2	0.5	0.1	0.5	0.4	0.5	-0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	-0.7	-0.8	-0.1	0.1	-0.8	0.5	0.3	0.5	-0.4	-0.1	-0.0	0.6	0.4	0.5	0.2	0.3	-0.0	-0.2
Whole body fat mass	0.2	0.9	6.4	-1.9	-2.5	-0.5	0.5	-1.0	0.0	0.7	0.1	-1.5	-0.3	0.2	0.5	0.2	0.5	0.6	0.7	-0.1	-0.3
Leg fat mass (right)	0.2	0.7	4.2	-2.0	-1.9	-0.8	0.1	-1.0	-0.2	0.3	-0.4	-1.4	-0.6	-0.2	0.1	-0.1	-0.0	0.2	0.3	-0.0	-0.5
Alcohol intake frequency.	0.2	0.5	1.5	-0.6	-0.6	-0.9	0.6	-1.1	0.4	0.5	0.9	-1.2	-0.2	0.9	0.3	0.2	0.4	0.6	0.5	-0.7	-0.4
Chest pain or discomfort	0.2	0.3	2.0	0.4	0.1	1.4	-0.0	-0.8	0.5	0.3	1.0	0.0	-0.2	-0.5	0.4	0.3	0.4	0.2	0.3	0.3	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	0.7	-0.3	0.4	0.5	-0.2	0.5	0.6	0.2	0.0	0.3	-0.2	1.0	0.8	0.8	0.4	0.6	-0.2	0.1
Supplements: Vitamin C	0.2	0.2	0.9	-0.9	-0.5	-0.9	-0.3	-0.1	-0.4	-0.2	-1.0	-0.7	-0.5	-0.3	-0.1	-0.2	-0.2	-0.2	-0.2	-0.6	0.1
Knee pain experienced in last month	0.2	0.3	1.2	-0.7	-1.1	-0.1	-0.6	0.3	-0.8	-0.5	0.3	0.2	-0.7	-0.6	-0.7	-0.6	-0.8	-0.5	-0.5	0.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.3	-0.2	-1.2	0.2	0.1	-0.4	-0.3	-0.0	0.6	0.2	-0.9	-0.3	-0.2	-0.2	-0.2	-0.1	-0.1	1.1	-0.0
Illnesses of siblings: Diabetes	0.2	0.2	1.3	0.2	-1.1	0.7	-0.1	0.1	-0.2	0.0	0.7	-0.5	-0.2	-0.5	0.1	-0.0	0.1	-0.1	0.0	0.1	-0.8
Arm fat percentage (left)	0.2	0.7	6.6	-1.9	-2.6	-0.2	0.5	-0.3	0.1	0.6	0.3	-0.9	-0.0	0.3	0.3	0.2	0.4	0.6	0.7	0.3	-0.2
Medication for cholesterol	0.2	0.3	0.8	-0.7	-0.3	0.2	-0.9	-0.6	-0.5	-0.7	0.3	-0.4	-0.8	-0.3	-0.6	-0.6	-0.3	-0.6	-0.6	-0.5	-0.8
Mineral and other dietary supplements	0.2	0.2	1.6	0.6	0.3	0.3	0.0	0.1	-0.1	-0.2	1.2	0.5	0.7	0.7	-0.2	-0.2	-0.0	-0.0	-0.2	-0.2	0.5
Medication: Aspirin	0.2	0.3	1.4	0.9	-0.7	1.2	0.2	1.0	-0.1	0.1	0.2	0.5	0.3	0.0	0.0	0.2	0.1	0.1	0.1	0.9	0.4
Arm fat mass (left)	0.2	1.0	7.0	-1.9	-2.6	-0.9	0.6	-1.0	0.0	0.7	0.0	-1.5	-0.3	0.3	0.4	0.2	0.4	0.7	0.7	0.1	-0.2
Medication: Blood pressure	0.2	0.4	1.4	0.5	0.1	-0.0	1.0	0.9	0.2	0.8	-0.7	-0.4	1.2	-0.1	0.6	0.5	0.2	0.6	0.8	0.2	0.5
Leg fat percentage (left)	0.2	0.7	4.4	-2.1	-1.6	-0.9	-0.0	-0.9	-0.3	0.2	-0.5	-1.1	-0.9	-0.5	-0.0	-0.1	-0.2	0.1	0.2	0.5	-0.4
Average weekly beer plus cider intake	0.2	0.3	1.7	0.4	1.3	-0.7	-0.3	1.0	-0.5	-0.3	-1.0	0.0	0.1	-0.4	-0.3	-0.2	-0.4	-0.3	-0.3	0.4	-0.0
Diastolic blood pressure, automated reading	0.2	0.7	3.5	-1.0	-0.9	-1.6	0.5	-1.4	0.2	0.3	0.2	-1.9	-1.1	-0.0	0.1	-0.1	0.0	0.3	0.3	0.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.3	0.3	-0.4	0.1	0.4	-0.6	0.7	0.5	1.1	-0.1	-0.3	0.7	0.5	0.5	0.6	0.6	0.5	0.4	0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.3	-0.5	-0.5	-0.2	0.7	0.1	0.1	0.7	-1.1	-0.5	0.4	0.3	0.6	0.6	0.6	0.7	0.8	-0.3	0.5
Leg fat mass (left)	0.2	0.8	4.8	-2.2	-1.9	-1.0	0.1	-1.2	-0.3	0.3	-0.4	-1.6	-0.7	-0.3	0.1	-0.1	-0.0	0.2	0.3	0.0	-0.5
Rheumatoid Arthritis	0.1	0.2	0.6	-0.6	0.2	0.3	0.1	0.7	0.2	0.4	-0.4	0.4	0.3	-0.4	0.3	0.4	0.1	0.2	0.4	0.7	0.4
Blood Eosinophil Count	0.1	0.8	4.9	-1.1	0.3	-1.9	0.4	-2.2	0.7	0.6	-0.5	-0.9	-0.6	0.2	0.6	0.3	0.2	0.6	0.6	-0.2	-0.2
Blood White Count	0.1	1.0	6.4	-0.3	2.5	-1.4	-0.5	-1.6	0.1	0.1	-0.7	-1.0	-0.7	-1.0	-0.2	-0.3	-0.6	-0.1	0.1	-0.7	-1.5
Heel T-Score	0.1	1.0	4.5	0.1	2.1	-1.5	-0.3	-2.0	0.4	-0.4	1.7	0.6	-0.7	0.2	-0.4	-0.2	-0.6	-0.3	-0.4	1.0	0.9
Height	0.1	1.7	6.1	-1.2	-2.2	0.1	1.1	-1.1	0.6	1.0	0.5	-2.3	0.8	1.0	1.2	0.7	1.5	1.0	1.1	-2.5	-0.6
Cardiovascular Disease	0.1	0.4	3.1	0.8	1.1	-0.5	0.4	0.5	-0.6	0.1	-1.8	-0.4	0.7	-0.1	-0.1	-0.0	-0.3	0.1	0.2	-0.6	0.8
Tanning	0.1	0.8	1.7	1.0	1.0	1.2	-1.0	1.3	-1.1	-1.2	-0.5	0.8	0.3	-0.8	-0.8	-0.8	-0.7	-1.2	-1.2	-0.1	-0.2
Fed-up feelings	0.1	0.2	1.9	0.1	0.4	0.5	-0.1	0.6	0.0	0.0	-1.4	0.2	0.0	-0.0	0.1	0.1	0.2	-0.0	0.0	0.5	0.1
Age when periods started (menarche)	0.1	0.3	2.2	0.2	0.6	0.5	-0.3	0.3	-0.4	-0.4	-0.4	0.5	-0.0	-0.5	-0.4	-0.2	-0.4	-0.4	-0.4	1.5	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	1.9	-0.1	0.0	0.1	0.1	-0.9	0.8	0.1	1.4	0.1	0.1	-0.1	-0.2	-0.1	-0.2	0.1	0.1	0.8	0.2
Waist circumference	0.1	0.5	3.7	-1.2	-1.9	-0.3	0.6	-0.7	0.0	0.8	0.2	-1.1	-0.0	0.1	0.5	0.3	0.4	0.7	0.8	0.2	0.0
Forced vital capacity (FVC)	0.1	0.6	1.9	-0.5	-1.2	0.4	-0.8	1.4	-0.8	-0.7	-0.4	-0.1	-0.2	-0.5	-0.5	-0.7	-0.5	-0.6	-0.7	-0.9	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.7	-0.7	-0.1	-0.5	0.5	-0.7	0.9	0.4	0.7	-0.0	0.0	0.0	-0.1	0.2	-0.1	0.4	0.4	1.3	0.4
Medication: Lansoprazole	0.1	0.2	0.6	0.1	-0.7	0.6	0.2	0.6	0.1	0.0	0.1	0.5	0.4	0.4	0.1	0.1	0.3	0.1	0.0	0.5	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.7	0.5	0.2	0.5	-0.4	0.2	-0.1	-0.3	0.4	0.5	-0.6	-0.1	-0.1	-0.2	0.0	-0.3	-0.3	0.8	-0.1
Leg fat percentage (right)	0.1	0.4	2.8	-1.7	-1.5	-0.4	0.1	-0.5	-0.1	0.3	-0.2	-0.7	-0.5	-0.4	0.0	0.0	-0.1	0.2	0.3	0.7	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.3	-0.4	0.6	-0.2	-0.1	0.0	-0.1	0.1	-0.1	-0.3	-0.4	-0.3	-0.2	-0.2	-0.2	-0.2	-0.1	-0.2
Blood Red Count	0.0	0.2	1.1	-0.2	0.9	-1.0	-0.6	0.3	0.2	-0.2	0.4	0.5	-0.2	-0.6	-0.1	-0.0	-0.5	-0.3	-0.2	0.7	0.0
Hair Pigment	0.0	0.9	5.2	-1.7	-0.9	-1.0	0.3	0.9	0.2	0.8	-2.3	-0.9	0.8	-0.3	0.9	0.6	0.4	0.6	0.9	-0.3	-0.3

Hub : Genes

PLEKHB1

Models

Trait associations