Hub : Genes

CLPB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Liver	0.246	0.095	0.00750	0.054	NA	-0.010	NA	0.024	1.3e-02	NA	8.0e-01	NA	7.1e-02
2	GTEx	Testis	0.391	0.077	0.00001	0.339	NA	0.283	NA	0.336	9.6e-16	NA	5.3e-13	NA	1.3e-15
3	TCGA	Testicular Germ Cell Tumors	0.172	0.087	0.00830	0.017	0.001	-0.008	NA	-0.001	8.1e-02	0.3	8.8e-01	NA	3.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.6	0.9	2.3	0.3	1.5	-0.6
Bipolar Disorder or Schizophrenia	0.5	1.1	1.9	1.4	1.1	0.5
Depressed Affect (Nagel 2018)	1.1	2.2	4.8	2.2	-0.9	1.1
Depression (Nagel 2018)	1.3	2.0	3.2	1.8	-1.7	0.2
Intelligence (Savage-Jansen 2018)	1.5	4.7	10.7	-3.3	1.5	1.0
Neuroticism (Nagel 2018)	1.6	3.8	7.7	2.8	-1.4	1.3
Schizophrenia (2018)	0.6	1.2	2.4	1.5	0.2	1.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	-0.3	-0.1	0.5
Worry (Nagel 2018)	2.0	4.3	8.9	3.0	-1.7	1.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.5	1.2	0.4	-0.8
Alzheimer’s Disease (in father)	0.5	0.6	1.4	1.2	-0.6	0.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	1.1	0.1	-0.1
Crohns Disease (2017)	0.5	1.1	2.4	1.5	0.5	-0.7
Irritable Bowel Disease (IBD)	0.4	0.9	1.4	0.5	1.1	-1.2
Ulcerative Colitis (UC)	0.9	1.6	2.3	-1.1	1.5	-1.1
Major Depression (MDD)	0.3	0.4	0.6	-0.2	-0.8	0.6
Reaction Time	0.5	0.9	1.2	1.1	-1.0	0.7
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.4	-1.9	0.9	1.4
Breast Cancer	0.9	2.1	4.3	-1.1	2.1	-0.8
Ovarian Cancer	0.2	0.2	0.6	0.8	-0.2	-0.0
Prostate Cancer	0.9	1.2	1.9	1.1	1.4	-0.7
Age at First Birth	1.9	2.7	7.6	-2.8	-0.0	0.7
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.8	0.3	-0.6
Coronary Artery Disease (CAD)	0.3	0.3	0.9	-0.9	0.2	-0.0
Crohns Disease (2012)	0.4	0.6	1.1	1.0	-0.6	0.6
Mean Putamen Volume	2.8	3.2	4.8	-1.6	-2.2	1.5
Fasting Glucose	5.5	6.6	15.1	-3.9	1.6	-1.4
HbA1C	1.2	1.3	3.3	-1.8	0.5	-0.6
HDL Cholesterol	0.2	0.3	0.5	0.5	-0.3	0.7
LDL Cholesterol	3.3	5.2	11.1	0.9	-3.3	1.9
Lupus	1.0	1.6	2.2	0.6	-1.5	1.4
Neuroticism (2016)	1.2	1.7	3.9	2.0	1.0	0.5
Primary Biliary Cirrhosis	0.2	0.2	0.5	-0.1	0.7	-0.4
Rheumatoid Arthritis	0.0	0.0	0.0	0.2	0.1	0.1
Schizophrenia (2014)	0.3	0.6	1.1	1.0	0.6	0.7
Triglycerides	0.2	0.4	0.8	0.9	0.4	-0.4
Type 2 Diabetes (T2D) (2012)	4.0	4.6	13.2	-3.6	-0.5	0.7
Ulcerative Colitis	0.5	0.8	1.4	-0.3	1.2	-0.9
Blood Eosinophil Count	0.1	0.8	1.1	1.1	-1.1	-0.6
Blood Platelet Count	0.1	0.7	1.2	-0.8	0.3	1.1
Blood Red Count	0.0	0.3	0.4	0.6	0.7	-0.2
Blood White Count	0.3	2.0	3.5	1.9	0.4	1.6
Heel T-Score	1.3	10.7	16.6	-3.7	4.1	-1.3
BMI	0.9	5.4	8.1	1.2	2.6	-2.8
Height	0.1	1.0	1.4	0.3	1.2	-1.2
Waist Hip Ratio (WHR)	0.2	1.1	2.3	-1.5	-0.7	0.8
Systolic Blood Pressure	0.8	3.8	8.3	0.1	-1.8	2.9
Smoking Status	1.9	4.6	10.5	3.2	-1.3	1.2
Allergy or Eczema	0.5	1.4	2.5	-1.6	-1.2	0.4
Cardiovascular Disease	0.1	0.4	0.7	-0.8	-0.1	0.7
Hypothyroidism (self reported)	1.6	3.7	5.8	2.0	1.1	-2.4
Respiratory disease	0.2	0.4	0.7	-0.3	-0.8	0.6
Type 2 Diabetes (T2D) (2018)	6.0	11.1	30.7	-5.5	0.0	1.7
Lung FEV1/FVC ratio	3.8	19.5	55.3	7.4	-1.8	-0.1
Lung FVC	1.2	6.0	16.3	-4.0	1.1	-0.8
Neuroticism	1.0	2.4	6.6	2.6	-0.7	0.4
Chronotype (morning person)	2.7	6.2	8.1	2.9	2.4	-2.2
Hair Pigment	0.0	0.5	1.0	1.0	-0.6	-0.1
Tanning	0.0	0.3	0.7	0.4	-0.2	-0.8
Hand grip strength (left)	0.7	1.9	4.5	0.8	2.1	-0.7
Number of treatments/medications taken	0.5	0.9	2.5	-1.6	-0.1	0.3
Average weekly spirits intake	0.8	1.0	1.8	1.3	1.1	0.3
Sensitivity / hurt feelings	0.5	0.9	2.5	1.6	-0.5	-0.0
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.0	1.0	-0.5	-0.4
Hearing difficulty/problems: Yes	0.4	0.6	1.0	0.2	1.0	-0.8
Relative age of first facial hair	0.4	0.8	1.4	0.4	-1.2	0.9
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	-0.4	1.2	-0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	0.6	1.1	0.3
Ever had hysterectomy (womb removed)	0.8	0.9	1.5	1.2	1.1	0.1
Systolic blood pressure, automated reading	1.2	3.5	8.3	0.9	-1.1	2.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	-0.3	0.5	0.5
Angina	0.6	0.8	1.9	-0.7	1.4	-0.4
Medication for hormone replacement therapy	0.2	0.2	0.2	-0.5	0.3	0.5
Vitamin and mineral supplements	1.2	1.6	3.0	1.4	-1.7	0.2
Supplements: Zinc	1.4	1.5	3.2	-1.1	1.8	0.4
Medication: Co-codamol	1.8	2.1	3.6	1.3	-1.9	0.9
Medication: Metformin	2.8	4.0	5.9	-2.4	-0.9	2.3
Diabetes (father)	1.3	1.6	2.9	-1.7	1.1	-0.8
Diabetes (mother)	2.8	3.6	6.3	-2.5	-0.4	2.1
Severe depression (siblings)	1.5	1.7	4.5	2.1	-0.6	0.5
Pack years adult smoking proportion	0.4	0.6	1.2	0.8	-0.0	-1.1
Impedance of leg (right)	0.7	3.6	6.1	-2.5	-1.2	1.8
Leg fat-free mass (left)	1.1	5.9	9.4	3.1	2.3	-1.8
Trunk fat percentage	0.4	1.4	2.1	1.4	1.4	-0.5
Hand grip strength (right)	0.3	0.9	1.7	1.3	0.7	-0.7
Townsend deprivation index at recruitment	0.5	0.7	1.0	0.3	1.0	-1.0
Current tobacco smoking	3.2	5.3	13.5	3.7	-1.4	0.6
Average weekly fortified wine intake	0.3	0.3	0.6	-0.6	-0.8	0.3
Maternal smoking around birth	1.8	2.6	3.3	1.8	1.7	-1.2
Fed-up feelings	0.9	1.7	2.1	1.2	-1.4	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	3.8	1.5	-2.0	0.3
Relative age voice broke	0.2	0.3	0.5	-0.7	-0.6	0.0
Taking other prescription medications	0.2	0.4	0.8	-0.5	0.9	0.2
Age when periods started (menarche)	0.5	1.2	2.9	0.7	-1.7	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	1.1	0.4	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	-0.2	0.7	0.6
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.1	1.3	-0.7	1.8
Qualifications: CSEs or equivalent	1.5	2.0	4.2	1.3	0.2	-2.0
Serious illness, injury or assault to yourself	0.3	0.4	0.9	0.1	0.9	-0.6
High blood pressure	0.2	0.6	1.3	-0.3	1.1	0.7
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.8	-1.7	-1.0	1.2
Multivitamins +/- minerals	1.2	1.6	3.5	-1.1	1.9	0.3
Stomach or abdominal pain in last month	1.2	1.6	2.5	-0.6	1.6	-1.3
Supplements: Glucosamine	0.9	1.2	2.1	-1.0	0.6	-1.4
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	-0.8	0.4	0.4
Medication: Atenolol	1.2	1.5	3.0	0.1	1.7	-1.2
Medication: Levothyroxine sodium	0.5	0.9	1.6	1.3	0.5	-1.0
Sitting height	0.1	0.5	0.7	0.9	0.7	-0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.4	0.8	-0.9
High blood pressure (mother)	1.9	2.6	4.6	0.9	-1.6	2.1
Body mass index (BMI)	1.0	4.3	6.4	1.7	2.5	-1.9
Impedance of leg (left)	0.6	3.1	6.9	-2.6	-0.8	1.3
Leg predicted mass (left)	1.1	6.0	9.4	3.1	2.3	-1.8
Trunk fat mass	0.8	3.2	4.6	1.8	2.1	-1.3
Waist circumference	1.1	4.2	6.5	1.5	2.6	-1.9
Number of incorrect matches in round	0.6	1.0	1.8	-1.3	-0.5	-1.0
Past tobacco smoking	0.3	0.5	1.0	-0.7	-1.0	-0.2
Alcohol usually taken with meals	0.9	1.5	2.8	-1.0	-0.8	1.7
Nervous feelings	0.8	1.5	3.2	1.8	-1.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.8	-0.5	0.0	1.4
Hearing difficulty/problems with background noise	2.6	4.2	8.1	-0.8	2.0	-2.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	-0.7	0.3	0.7
Had menopause	0.9	1.1	2.6	-1.6	-0.7	0.5
Had other major operations	0.1	0.1	0.1	-0.2	0.3	-0.4
Forced vital capacity (FVC)	0.5	2.1	3.8	-1.9	0.6	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.6	0.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.4	-1.2	0.7	0.1
Qualifications: None of the above	2.1	4.4	11.0	3.3	-1.5	-0.1
Financial difficulties in last 2 years	0.7	0.9	2.5	1.6	0.4	-0.3
Mouth/teeth dental problems	1.3	2.1	6.1	-2.5	0.2	0.3
Heart attack	1.4	1.8	2.7	-0.7	1.6	-1.5
Allergy	0.4	1.0	2.2	1.5	0.5	-0.7
Pain all over the body in last month	0.4	0.5	1.2	0.2	-1.1	0.3
Diabetes (self-reported)	3.8	5.9	14.6	-3.8	0.0	1.7
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.0	-2.0	-1.6	1.0
Medication: Ramipril	0.5	0.7	1.0	-1.0	0.7	-0.6
Medication: Simvastatin	0.7	1.0	2.2	-0.5	-0.8	1.5
Fluid intelligence score	1.6	3.3	7.7	-2.8	1.3	0.7
Illnesses of siblings	0.7	1.0	1.6	1.3	-0.5	1.1
Neuroticism score	0.7	1.4	4.3	2.1	-0.0	0.0
Weight	1.0	5.0	6.9	2.0	2.6	-2.0
Impedance of arm (right)	0.5	2.5	3.8	-1.0	-1.6	2.0
Arm fat percentage (right)	0.8	3.2	4.8	1.7	2.2	-1.4
Trunk fat-free mass	0.9	5.1	6.9	1.6	2.6	-2.4
Hip circumference	1.5	6.7	8.6	2.3	2.9	-2.4
Time employed in main current job	0.9	1.1	2.1	-1.5	0.2	-1.0
Alcohol intake versus 10 years previously	0.1	0.1	0.2	0.4	0.3	0.0
Father’s age at death	0.1	0.2	0.3	-0.2	-0.4	0.5
Worrier / anxious feelings	0.6	1.1	2.1	1.5	-0.5	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.0	1.0	0.5	0.8
Falls in the last year	1.2	1.6	3.0	-1.3	1.7	0.0
Hair/balding pattern: Pattern 3	0.2	0.2	0.5	-0.2	-0.7	0.4
Number of live births	1.5	2.1	5.9	2.4	-0.7	-0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.2	0.3	1.0	-2.0
Pulse rate	0.3	0.5	0.9	1.0	-0.4	-0.8
Happiness	0.3	0.4	0.9	1.0	0.2	0.5
Noisy workplace	0.5	0.6	0.7	0.8	-0.7	-0.8
Qualifications: A levels/AS levels or equivalent	1.7	3.8	6.9	-2.6	-0.7	2.0
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	4.1	-2.0	-1.1	1.6
Mouth/teeth dental problems: Dentures	3.2	5.4	15.7	4.0	-0.7	-0.0
Asthma	0.3	0.6	0.8	-0.7	-0.8	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.5	-0.2	0.1	-1.2
Medication: Cholesterol lowering	1.6	2.5	5.8	-2.4	0.1	1.3
Depression (self-reported)	0.5	0.6	1.5	-0.1	-1.2	0.6
Medication: Lansoprazole	1.3	1.5	3.9	-0.5	0.6	-2.0
Prospective memory result	1.2	1.5	3.6	1.9	0.5	0.7
Lung cancer (father)	0.4	0.4	1.1	0.5	-0.0	-1.1
Illnesses of mother	1.8	2.3	3.6	-0.8	1.6	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	3.5	0.5	0.4	-1.9
Pulse wave Arterial Stiffness index	0.4	0.4	0.8	0.9	0.7	-0.1
Impedance of arm (left)	1.1	5.3	7.8	-0.5	-2.8	2.8
Arm fat mass (right)	1.0	4.1	5.4	1.9	2.3	-1.8
Trunk predicted mass	0.9	5.2	7.1	1.6	2.7	-2.4
Standing height	0.1	1.0	1.7	1.3	0.7	-0.9
Length of working week for main job	0.5	0.6	1.1	1.0	0.7	-0.4
Exposure to tobacco smoke at home	0.9	1.0	2.4	0.7	-1.6	0.1
Breastfed as a baby	3.2	4.0	7.8	0.4	-2.0	2.8
Tense / ‘highly strung’	0.0	0.1	0.2	0.4	0.2	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	8.8	0.6	-1.3	3.0
Hair/balding pattern: Pattern 4	0.4	1.1	2.3	-0.0	-1.5	0.9
Birth weight of first child	1.7	3.1	7.1	-1.2	2.7	-0.9
Peak expiratory flow (PEF)	1.1	2.6	4.3	0.6	1.8	-2.1
Pulse wave reflection index	0.8	1.0	2.4	-0.8	1.6	0.3
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.4	-0.6	0.6	-0.4
Loud music exposure frequency	1.0	1.1	1.7	1.3	-1.1	0.6
Qualifications: O levels/GCSEs or equivalent	2.2	3.6	6.0	-2.1	2.4	-0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	0.5	0.4	-0.1
Blood clot in the leg (DVT)	1.0	1.2	2.7	0.1	1.0	-1.6
Medication: Paracetamol	0.1	0.2	0.4	0.5	-0.6	-0.1
Headache pain in last month	1.2	2.1	4.5	-2.1	0.9	1.0
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	5.7	2.4	0.5	-1.5
Glaucoma (self-reported)	0.1	0.1	0.1	-0.3	0.3	0.3
Gout (self-reported)	4.1	5.6	7.5	-2.2	2.7	-2.2
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	4.3	2.1	0.9	-1.3
Medication: Amlodipine	0.3	0.4	1.0	0.6	0.2	1.0
Medication: Ventolin 100micrograms inhaler	3.0	3.9	5.1	1.6	-2.0	2.3
Birth weight	0.2	0.3	0.6	0.8	-0.2	-0.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	1.4	-0.1	-0.6
High blood pressure (siblings)	0.4	0.6	1.1	0.2	1.0	-0.8
Forced vital capacity (FVC), Best measure	0.5	1.8	2.6	-1.5	0.7	-1.6
Body fat percentage	0.5	1.9	3.1	1.4	1.8	-0.8
Leg fat percentage (right)	0.6	2.1	3.7	1.1	1.9	-1.2
Arm fat-free mass (right)	1.1	5.5	5.9	2.2	2.4	-2.4
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.4	-0.1	0.5
Comparative body size at age 10	0.2	0.5	1.2	1.1	0.5	0.2
Number of full brothers	0.2	0.3	0.6	0.8	0.4	-0.2
Worry too long after embarrassment	0.1	0.1	0.3	0.5	0.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	2.6	1.4	-1.4	1.6
Wheeze or whistling in the chest in last year	0.7	1.2	2.5	1.0	1.6	-0.1
Number of children fathered	1.0	1.1	3.1	1.8	0.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.2	0.5	-1.5	0.1
Age at first live birth	0.9	1.5	3.8	-1.9	-0.1	0.9
Pulse wave peak to peak time	0.3	0.3	0.6	-0.6	-0.8	0.0
Health satisfaction	0.1	0.1	0.4	-0.2	0.6	0.1
Shortness of breath walking on level ground	1.9	2.2	6.0	-0.7	2.5	-0.3
Qualifications: College or University degree	0.7	2.4	5.4	-2.3	0.3	1.3
Eye problems/disorders: None of the above	0.5	0.6	1.2	0.7	-1.1	-0.2
Mouth/teeth dental problems: Loose teeth	1.6	1.9	3.9	0.1	1.3	-2.0
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.0	-0.2	-0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	0.5	0.6	-0.1
Neck or shoulder pain in last month	0.4	0.5	1.3	-1.1	-0.4	0.2
Medication: Blood pressure	0.7	1.3	3.4	-1.8	-0.1	0.7
Angina (self-reported)	0.7	0.9	1.9	-0.5	1.4	-0.7
Migraine (self-reported)	0.7	0.9	2.3	0.2	-1.5	0.6
Medication: Ibuprofen	0.3	0.4	0.9	0.2	-0.5	-1.0
Medication: Allopurinol	3.8	5.1	7.3	-2.1	2.7	-1.9
Medication: Omeprazole	0.6	0.7	2.0	0.2	1.4	-0.1
Medication: Seretide 50 evohaler	1.3	1.5	1.7	-1.0	-1.3	1.3
Mean time to correctly identify matches	0.2	0.4	0.8	0.2	-0.9	0.5
Heart disease (mother)	0.2	0.3	0.4	-0.6	0.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.5	-0.8	1.6	-0.9
Whole body fat mass	0.8	3.4	4.7	1.9	2.2	-1.3
Leg fat mass (right)	1.1	4.1	6.8	1.6	2.6	-1.7
Arm predicted mass (right)	1.0	5.0	6.1	1.9	2.5	-2.3
Pulse rate, automated reading	0.9	2.8	8.0	2.8	-0.4	0.5
Alcohol intake frequency.	1.0	2.3	4.0	2.0	-1.6	0.4
Comparative height size at age 10	0.2	1.3	2.2	1.5	1.0	-0.8
Number of full sisters	0.6	0.7	1.1	1.1	0.2	-1.0
Suffer from ‘nerves’	1.9	3.0	6.6	2.6	-1.5	0.3
Overall health rating	0.1	0.2	0.5	0.5	0.7	0.1
Chest pain or discomfort	1.3	1.8	5.0	-0.7	2.2	-0.3
Had major operations	0.5	0.6	1.6	0.4	-1.3	-0.3
Age at last live birth	0.3	0.5	1.3	-1.1	0.2	0.3
Family relationship satisfaction	0.1	0.1	0.2	-0.2	0.4	-0.4
Leg pain on walking	0.2	0.3	0.5	-0.7	0.6	0.2
Qualifications: NVQ or HND or HNC or equivalent	3.6	4.4	5.9	-1.7	2.4	-2.1
Commuting to job workplace: Car/motor vehicle	3.6	4.1	9.0	3.0	-1.5	1.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.2	-0.3	-0.5
Medication: Aspirin	0.7	0.9	2.5	-1.6	0.2	0.3
Supplements: Vitamin C	0.1	0.1	0.1	-0.2	-0.3	0.2
Knee pain experienced in last month	0.4	0.6	1.2	-1.1	0.4	-0.6
Hypertension (Self-reported)	0.2	0.6	1.3	-0.4	1.1	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.3	-0.7	1.5	-1.4
Illnesses of father: Heart disease	2.6	3.6	9.4	-3.1	1.1	0.4
Illnesses of siblings: Diabetes	2.9	3.6	8.4	-2.9	-0.3	-1.5
Smoking status: Previous	0.2	0.4	0.5	-0.3	0.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	0.5	1.0	-0.3
Whole body fat-free mass	1.1	6.0	7.0	2.3	2.6	-2.5
Leg fat-free mass (right)	1.2	6.3	9.1	3.0	2.5	-2.0
Arm fat percentage (left)	0.7	2.7	4.8	2.2	1.6	-0.9
Average weekly red wine intake	0.3	0.5	1.2	-0.3	0.5	-1.1
Handedness (chirality/laterality): Left-handed	1.8	2.2	3.8	-1.3	2.0	-1.0
Mood swings	1.5	2.7	7.1	2.7	0.2	1.0
Loneliness, isolation	0.8	1.0	2.0	1.4	-0.2	1.0
Long-standing illness, disability or infirmity	2.1	3.2	7.0	-2.6	0.6	1.5
Ever had bowel cancer screening	1.7	1.9	3.7	-0.7	-1.9	1.3
Diabetes diagnosed by doctor	4.8	7.9	20.5	-4.5	0.7	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	0.2	-0.2	-0.9
Friendships satisfaction	0.2	0.2	0.4	-0.0	0.6	-0.5
Qualifications: nursing, teaching	0.8	1.2	3.4	-1.8	-0.6	-0.0
Commuting to job workplace: Walk	0.4	0.4	0.6	-0.8	-0.8	-0.1
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.4	0.5	0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	0.9	-1.3	-0.2
Medication for cholesterol	0.2	0.3	0.7	0.0	0.3	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.5	-0.4	-1.2	1.2
Back pain experienced in last month	2.0	3.0	4.7	0.9	1.9	-2.2
Mineral and other dietary supplements	1.0	1.3	2.5	1.6	-0.4	1.1
Breast cancer (self-reported)	0.3	0.4	0.8	0.5	-0.9	0.4
Asthma (self-reported)	0.2	0.5	0.7	-0.6	-0.8	0.6
Osteoporosis (self-reported)	0.6	0.8	2.1	1.4	-0.3	-0.3
Osteoarthritis (self-reported)	0.7	0.9	2.0	-0.5	-0.7	1.4
Medication: Aspirin	1.1	1.5	4.0	-2.0	0.5	0.4
Medication: Gliclazide	0.3	0.4	0.5	-0.7	-0.5	0.6
Illnesses of father: None of the above (group 1)	1.5	1.9	3.4	1.9	-1.5	-0.2
Smoking status: Current	3.2	5.1	13.0	3.6	-1.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.3	0.3	-0.2	-1.5
Whole body water mass	1.1	6.2	7.1	2.4	2.7	-2.4
Leg predicted mass (right)	1.2	6.3	9.1	3.0	2.4	-2.0
Arm fat mass (left)	0.9	3.8	4.5	2.1	2.1	-1.6
Number of self-reported non-cancer illnesses	0.3	0.4	1.2	-1.1	-0.4	0.1
Average weekly champagne plus white wine intake	1.3	1.8	3.1	-1.8	1.4	-0.4
Miserableness	0.7	1.2	3.5	1.9	0.4	-0.3
Guilty feelings	0.3	0.4	1.0	1.0	0.1	-0.3
Wears glasses or contact lenses	0.9	1.1	1.4	0.9	-1.2	1.0
Ever taken oral contraceptive pill	0.8	0.9	1.3	0.7	0.9	1.1
Hearing aid user	1.0	1.1	2.0	1.4	-0.4	1.1
Mother’s age at death	1.9	2.4	2.5	-1.5	-1.6	1.6
Financial situation satisfaction	1.3	1.6	3.6	0.5	1.9	-1.0
Tinnitus: Yes, now most or all of the time	0.7	0.9	1.4	1.1	-1.2	-0.1
Commuting to job workplace: Public transport	2.5	2.9	6.1	-2.5	1.2	-1.2
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.3	0.2	-0.6
Medication: Blood pressure	0.2	0.4	0.7	-0.6	0.8	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.5	0.7	0.1	-0.1
Supplements: Fish oil (including cod liver oil)	2.1	2.8	7.1	-2.7	0.8	-0.8
High cholesterol (Self-reported)	0.3	0.5	0.9	-1.0	0.7	0.5
Medication: Bendroflumethiazide	1.2	1.9	2.9	-1.4	-0.8	1.7
Medication: Paracetamol	0.1	0.1	0.2	0.3	-0.5	0.2
Medication: Lisinopril	0.9	1.2	2.4	0.6	-0.9	1.5
Medication: Atorvastatin	0.9	1.1	2.0	-1.4	0.9	0.8
Illnesses of father: High blood pressure	0.9	1.1	2.0	1.4	1.1	-0.3
Alcohol drinker status: Never	1.2	1.5	3.3	-0.0	-1.1	-1.8
Ever smoked	0.4	0.7	1.0	1.0	0.8	0.7
Basal metabolic rate	1.1	6.2	7.4	2.3	2.7	-2.4
Leg fat percentage (left)	0.8	2.8	5.5	1.0	2.4	-1.4
Arm fat-free mass (left)	1.2	6.2	8.3	1.8	2.9	-2.7
Number of operations (self-reported)	0.8	1.2	3.4	0.3	-0.1	-1.8
Average weekly beer plus cider intake	1.4	2.0	4.4	-0.2	1.3	-2.1
Irritability	0.1	0.2	0.2	0.3	0.4	0.4
Risk taking	0.2	0.3	0.4	0.5	0.6	-0.3
Ever had prostate specific antigen (PSA) test	2.2	2.6	3.9	-1.4	-2.0	1.4
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.5	-0.2	-0.0
Age started oral contraceptive pill	2.1	2.6	4.8	-2.2	-1.0	1.5
Diastolic blood pressure, automated reading	1.5	4.6	7.8	1.7	-1.8	2.8
Ever depressed for a whole week	1.1	1.3	2.1	-1.4	1.4	0.0
Unable to work because of sickness or disability	1.3	1.7	2.6	1.3	-1.6	0.9
Commuting to job workplace: Cycle	0.7	0.9	2.4	-1.6	-0.5	0.1
Myopia	0.3	0.5	1.3	0.5	-0.1	-1.1
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.1	0.3	-1.1	-0.9
Cholesterol lowering medication	0.7	1.0	2.3	0.6	-0.7	1.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.7	-0.1	1.3	-0.4
Pain experienced in last month	0.6	1.1	2.0	1.4	-0.7	0.8
Supplements: Calcium	1.1	1.2	3.3	-1.8	-0.4	-0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.8	-0.2	-0.4	0.9
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.0	-0.4	1.6	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.2	0.4	1.1	-1.8
Heart disease (siblings)	1.2	1.5	4.0	-0.6	2.0	-0.4
Alcohol drinker status: Previous	0.4	0.5	0.9	0.3	-1.0	0.6
Pack years of smoking	0.3	0.5	1.1	0.6	-0.1	-1.0
Impedance of whole body	0.8	3.8	4.9	-1.8	-1.9	2.2
Leg fat mass (left)	1.2	4.6	7.7	1.6	2.8	-1.9
Arm predicted mass (left)	1.3	6.6	8.2	1.8	2.9	-2.8