[Hub]/) : Traits : Lung FVC :

chr3:48,702,606-51,398,958

Best TWAS P=6.94e-13 · Best GWAS P=2.57e-09 conditioned to 4.9e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HEMK1 0.04 0.05 lasso 3 0.05 2.6e-06 -5.8 5.6 2.5e-08 -0.83 0.23 0.77 FALSE
2 GTEx Adipose Subcutaneous RNF123 0.19 0.18 enet 29 0.18 2.1e-14 -5.6 -6.0 2.7e-09 0.16 0.02 0.98 FALSE
3 GTEx Adipose Visceral Omentum HEMK1 0.07 0.05 lasso 3 0.04 3.2e-03 -5.6 5.6 2.5e-08 -0.86 0.15 0.56 FALSE
4 GTEx Adipose Visceral Omentum RNF123 0.08 0.11 lasso 4 0.07 2.2e-04 -5.6 -5.8 5.6e-09 0.18 0.03 0.97 FALSE
5 GTEx Artery Aorta SEMA3B-AS1 0.67 0.00 enet 61 0.12 5.0e-07 -5.3 -5.5 3.6e-08 0.42 0.04 0.70 FALSE
6 GTEx Artery Tibial HEMK1 0.03 0.03 enet 3 0.02 7.1e-03 -5.5 5.6 1.8e-08 -0.88 0.06 0.92 FALSE
7 GTEx Artery Tibial RNF123 0.08 0.08 enet 12 0.09 2.5e-07 -5.6 -6.1 8.0e-10 0.13 0.02 0.97 FALSE
8 GTEx Brain Caudate basal ganglia HEMK1 0.15 0.12 lasso 9 0.13 1.2e-04 -5.3 5.6 1.6e-08 -0.85 0.17 0.78 FALSE
9 GTEx Brain Caudate basal ganglia RNF123 0.13 0.04 enet 20 0.02 1.2e-01 -5.6 -6.1 1.3e-09 0.16 0.03 0.88 FALSE
10 GTEx Brain Cerebellar Hemisphere RNF123 0.20 0.24 enet 29 0.20 7.7e-06 -5.6 -5.4 7.2e-08 0.21 0.03 0.96 FALSE
11 GTEx Brain Cerebellum HEMK1 0.14 0.10 lasso 3 0.07 5.2e-03 -5.6 5.7 1.3e-08 -0.85 0.06 0.44 FALSE
12 GTEx Brain Cerebellum RNF123 0.36 0.31 enet 43 0.36 2.4e-11 -5.6 -5.5 3.4e-08 0.07 0.03 0.97 FALSE
13 GTEx Brain Cerebellum FAM212A 0.27 0.35 lasso 5 0.34 9.7e-11 -5.6 -5.6 2.2e-08 0.19 0.02 0.98 FALSE
14 GTEx Brain Cortex HEMK1 0.16 0.01 enet 19 0.03 6.1e-02 -4.8 5.4 5.1e-08 -0.81 0.05 0.58 FALSE
15 GTEx Brain Frontal Cortex BA9 RNF123 0.25 0.28 enet 34 0.05 2.3e-02 -5.6 -5.5 3.9e-08 0.13 0.03 0.97 FALSE
16 GTEx Breast Mammary Tissue RNF123 0.11 0.07 enet 14 0.02 3.2e-02 -5.6 -5.5 4.2e-08 0.17 0.03 0.96 FALSE
17 GTEx Breast Mammary Tissue (Female) NICN1 0.01 0.00 lasso 1 0.01 1.6e-01 -5.1 5.1 3.0e-07 0.01 0.02 0.09 FALSE
18 GTEx Cells EBV-transformed lymphocytes AMT 0.07 0.07 lasso 1 0.01 1.5e-01 -5.1 5.1 2.8e-07 0.06 0.16 0.23 FALSE
19 GTEx Cells Transformed fibroblasts UBA7 0.07 0.06 enet 5 0.04 7.5e-04 -5.5 5.5 3.5e-08 -0.20 0.03 0.97 FALSE
20 GTEx Colon Sigmoid HEMK1 0.08 0.08 lasso 13 0.06 2.6e-03 -4.7 5.1 2.6e-07 -0.70 0.13 0.64 FALSE
21 GTEx Colon Sigmoid RNF123 0.22 0.10 enet 23 0.20 1.1e-07 -4.9 -6.1 1.1e-09 0.08 0.05 0.94 FALSE
22 GTEx Colon Transverse C3orf18 0.04 0.01 lasso 4 0.00 1.8e-01 -5.9 -6.1 1.4e-09 0.91 0.03 0.91 FALSE
23 GTEx Colon Transverse RNF123 0.16 0.05 enet 36 0.05 2.3e-03 -4.8 -7.2 6.9e-13 0.08 0.13 0.55 TRUE
24 GTEx Colon Transverse UBA7 0.28 0.30 lasso 2 0.30 1.1e-14 -5.6 5.5 3.4e-08 -0.20 0.02 0.98 FALSE
25 GTEx Esophagus Gastroesophageal Junction RNF123 0.14 0.13 enet 30 0.10 2.3e-04 -4.9 -6.0 1.7e-09 0.02 0.27 0.62 FALSE
26 GTEx Esophagus Mucosa UBA7 0.04 0.07 enet 8 0.05 4.5e-04 -5.5 5.3 1.0e-07 -0.19 0.03 0.96 FALSE
27 GTEx Esophagus Mucosa FAM212A 0.19 0.26 enet 24 0.27 4.4e-18 -5.6 -5.5 3.2e-08 0.20 0.02 0.98 FALSE
28 GTEx Esophagus Muscularis RASSF1 0.10 0.00 lasso 7 0.01 8.7e-02 -4.0 -6.1 1.4e-09 0.53 0.06 0.62 FALSE
29 GTEx Esophagus Muscularis RNF123 0.15 0.14 enet 17 0.14 1.2e-08 -5.6 -5.6 2.5e-08 0.20 0.02 0.98 FALSE
30 GTEx Esophagus Muscularis SEMA3B-AS1 0.47 0.00 lasso 7 0.00 5.9e-01 -6.0 -6.6 4.2e-11 0.95 0.03 0.87 TRUE
31 GTEx Heart Atrial Appendage HEMK1 0.15 0.10 lasso 5 0.06 1.2e-03 -5.8 6.0 1.7e-09 -0.97 0.03 0.96 FALSE
32 GTEx Heart Atrial Appendage RNF123 0.06 0.04 lasso 2 0.02 4.0e-02 -5.5 -5.6 2.4e-08 0.19 0.05 0.86 FALSE
33 GTEx Heart Atrial Appendage SEMA3B-AS1 0.62 0.17 enet 83 0.32 3.8e-15 -5.8 -5.5 5.0e-08 0.50 0.02 0.98 FALSE
34 GTEx Heart Left Ventricle C3orf18 0.06 0.05 lasso 4 0.04 2.6e-03 -5.6 -5.5 3.5e-08 0.84 0.19 0.75 FALSE
35 GTEx Lung RNF123 0.13 0.05 enet 18 0.07 5.8e-06 -5.6 -6.7 2.0e-11 0.16 0.03 0.97 FALSE
36 GTEx Lung GPX1 0.04 0.02 enet 13 0.04 5.7e-04 4.7 -5.3 1.2e-07 0.10 0.06 0.74 FALSE
37 GTEx Muscle Skeletal C3orf18 0.05 0.06 enet 10 0.06 3.4e-06 -5.6 -5.8 4.9e-09 0.85 0.09 0.91 FALSE
38 GTEx Muscle Skeletal FAM212A 0.05 0.08 lasso 3 0.07 4.9e-07 4.8 -5.4 7.7e-08 0.19 0.12 0.88 FALSE
39 GTEx Muscle Skeletal SEMA3B-AS1 0.17 0.01 lasso 7 0.02 8.3e-03 -4.4 -5.3 1.2e-07 0.61 0.04 0.91 FALSE
40 GTEx Nerve Tibial RASSF1 0.05 0.03 enet 19 0.02 1.0e-02 -4.1 -5.9 4.3e-09 0.52 0.17 0.69 FALSE
41 GTEx Nerve Tibial HEMK1 0.09 0.13 lasso 7 0.12 8.3e-09 -5.6 5.6 2.2e-08 -0.85 0.15 0.85 FALSE
42 GTEx Nerve Tibial RNF123 0.24 0.16 lasso 5 0.15 1.0e-10 -5.5 -5.8 5.4e-09 0.18 0.03 0.97 FALSE
43 GTEx Nerve Tibial SEMA3B-AS1 0.25 0.04 lasso 5 0.03 3.3e-03 -5.3 -6.0 2.0e-09 0.83 0.05 0.94 FALSE
44 GTEx Nerve Tibial RP11-804H8.6 0.03 0.03 lasso 6 0.02 2.6e-02 -5.3 5.3 1.0e-07 -0.75 0.14 0.64 FALSE
45 GTEx Prostate C3orf18 0.18 0.08 lasso 9 0.11 1.1e-03 -4.5 -6.8 1.1e-11 0.61 0.09 0.61 FALSE
46 GTEx Skin Not Sun Exposed Suprapubic UBA7 0.07 0.03 lasso 6 0.06 2.9e-04 -5.1 6.1 7.8e-10 -0.05 0.08 0.89 FALSE
47 GTEx Skin Sun Exposed Lower leg CYB561D2 0.13 0.02 lasso 3 0.05 5.7e-05 -5.8 6.0 2.4e-09 -0.66 0.05 0.94 FALSE
48 GTEx Skin Sun Exposed Lower leg RNF123 0.06 0.00 enet 22 0.01 4.6e-02 3.7 -5.9 3.2e-09 0.11 0.04 0.79 TRUE
49 GTEx Skin Sun Exposed Lower leg UBA7 0.04 0.01 lasso 8 0.00 2.9e-01 -5.6 6.0 1.6e-09 -0.14 0.03 0.83 FALSE
50 GTEx Skin Sun Exposed Lower leg FAM212A 0.05 0.07 enet 16 0.06 1.1e-05 -5.6 -5.6 2.6e-08 0.20 0.02 0.97 FALSE
51 GTEx Spleen RNF123 0.13 0.13 lasso 5 0.10 1.3e-03 -5.6 -5.6 2.5e-08 0.20 0.03 0.86 FALSE
52 GTEx Spleen UBA7 0.19 0.14 lasso 22 0.11 8.8e-04 -5.5 5.4 8.1e-08 -0.22 0.03 0.94 FALSE
53 GTEx Spleen XXcos-LUCA11.4 0.10 0.08 lasso 5 0.02 9.0e-02 -5.6 -5.7 9.2e-09 0.88 0.06 0.72 FALSE
54 GTEx Stomach RNF123 0.23 0.12 lasso 15 0.16 4.6e-08 -4.9 -6.1 1.2e-09 0.08 0.07 0.93 FALSE
55 GTEx Testis CACNA2D2 0.08 0.06 lasso 6 0.05 4.1e-03 -3.8 5.1 2.7e-07 -0.74 0.18 0.72 FALSE
56 GTEx Thyroid RNF123 0.09 0.13 lasso 9 0.12 2.7e-09 -5.5 -5.6 2.3e-08 0.20 0.03 0.97 FALSE
57 METSIM Adipose RNF123 0.03 0.02 lasso 12 0.02 2.0e-04 -5.5 -5.4 5.8e-08 0.20 0.03 0.97 FALSE
58 NTR Blood UBA7 0.02 0.03 lasso 4 0.03 1.6e-09 -5.5 5.3 1.3e-07 -0.20 0.03 0.97 FALSE
59 ROSMAP Brain Pre-frontal Cortex C3orf18 0.03 0.00 bslmm 232 0.01 2.7e-02 -5.8 -5.2 2.5e-07 0.72 0.06 0.72 FALSE
60 ROSMAP Brain Pre-frontal Cortex HEMK1 0.07 0.13 lasso 5 0.13 7.9e-16 -5.6 6.0 2.0e-09 -0.91 0.06 0.94 FALSE
61 ROSMAP Brain Pre-frontal Cortex RNF123 0.04 0.05 lasso 3 0.05 1.4e-06 -5.5 -5.9 2.8e-09 0.14 0.03 0.97 FALSE
62 YFS Blood UBA7 0.16 0.24 lasso 6 0.23 4.0e-75 -5.6 5.6 2.5e-08 -0.20 0.03 0.97 FALSE
63 The Cancer Genome Atlas Breast Invasive Carcinoma AMIGO3 0.01 0.00 enet 13 0.01 5.7e-03 -4.8 -5.7 1.2e-08 0.09 0.02 0.40 FALSE
64 The Cancer Genome Atlas Breast Invasive Carcinoma GMPPB 0.03 0.03 enet 12 0.03 3.0e-07 -4.8 -5.6 1.6e-08 0.03 0.36 0.64 FALSE
65 The Cancer Genome Atlas Breast Invasive Carcinoma HEMK1 0.02 0.02 lasso 2 0.02 1.0e-04 -5.3 5.5 3.3e-08 -0.84 0.01 0.98 FALSE
66 The Cancer Genome Atlas Breast Invasive Carcinoma UBA7 0.01 0.01 enet 5 0.01 6.6e-04 -5.6 5.4 8.0e-08 -0.20 0.01 0.98 FALSE
67 The Cancer Genome Atlas Glioblastoma Multiforme AMIGO3 0.18 0.02 enet 24 0.07 2.9e-03 -4.8 -5.7 1.4e-08 0.08 0.02 0.48 FALSE
68 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma UBA7 0.02 0.02 blup 30 0.02 3.8e-03 -5.5 5.9 4.9e-09 -0.18 0.01 0.83 FALSE
69 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C3orf18 0.02 0.02 blup 28 0.02 8.1e-04 -5.5 -5.1 2.9e-07 0.84 0.02 0.89 FALSE
70 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HEMK1 0.01 0.00 blup 29 0.01 1.6e-02 -5.6 5.3 9.5e-08 -0.83 0.01 0.80 FALSE
71 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma UBA7 0.08 0.09 lasso 5 0.09 3.4e-10 -5.5 5.6 2.3e-08 -0.19 0.01 0.99 FALSE
72 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma UBA7 0.13 0.16 lasso 6 0.15 1.1e-08 -5.6 5.6 1.6e-08 -0.20 0.01 0.99 FALSE
73 The Cancer Genome Atlas Brain Lower Grade Glioma GMPPB 0.15 0.12 enet 17 0.13 1.2e-14 -4.8 -5.1 2.6e-07 0.01 0.44 0.56 FALSE
74 The Cancer Genome Atlas Brain Lower Grade Glioma HEMK1 0.04 0.06 blup 31 0.07 4.4e-08 -5.3 5.6 2.4e-08 -0.86 0.02 0.98 FALSE
75 The Cancer Genome Atlas Lung Adenocarcinoma AMIGO3 0.02 0.00 blup 40 0.00 3.0e-01 -5.6 -6.2 5.8e-10 0.14 0.01 0.81 FALSE
76 The Cancer Genome Atlas Lung Adenocarcinoma UBA7 0.03 0.04 enet 9 0.02 1.8e-03 -5.5 5.5 3.1e-08 -0.20 0.01 0.99 FALSE
77 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GMPPB 0.03 0.02 enet 13 0.02 1.3e-03 -4.8 -5.5 4.1e-08 0.01 0.03 0.36 FALSE
78 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma GMPPB 0.04 0.02 blup 40 0.02 1.4e-02 -5.6 -6.0 1.5e-09 0.12 0.01 0.71 FALSE
79 The Cancer Genome Atlas Pancreatic Adenocarcinoma UBA7 0.11 0.14 enet 7 0.11 2.7e-05 -5.5 5.5 3.6e-08 -0.21 0.01 0.98 FALSE
80 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma GMPPB 0.13 0.08 blup 40 0.09 2.7e-04 -4.8 -5.6 1.7e-08 0.02 0.06 0.32 FALSE
81 The Cancer Genome Atlas Prostate Adenocarcinoma CACNA2D2 0.04 0.07 lasso 1 0.06 4.6e-07 -6.0 6.0 2.6e-09 -1.00 0.01 0.99 FALSE
82 The Cancer Genome Atlas Prostate Adenocarcinoma HEMK1 0.05 0.06 lasso 3 0.05 6.6e-06 -5.6 5.6 1.7e-08 -0.85 0.01 0.99 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma IP6K1 0.03 0.04 blup 55 0.04 9.2e-05 -5.1 -5.7 1.2e-08 0.02 0.20 0.67 FALSE
84 The Cancer Genome Atlas Prostate Adenocarcinoma UBA7 0.05 0.04 enet 7 0.05 1.6e-05 -5.5 6.1 1.2e-09 -0.16 0.01 0.99 FALSE
85 The Cancer Genome Atlas Stomach Adenocarcinoma UBA7 0.04 0.05 lasso 1 0.04 1.0e-03 -5.5 5.5 4.4e-08 -0.20 0.01 0.95 FALSE
86 The Cancer Genome Atlas Testicular Germ Cell Tumors CYB561D2 0.08 0.04 blup 17 0.08 9.3e-04 -4.3 5.3 1.1e-07 -0.59 0.01 0.42 FALSE
87 The Cancer Genome Atlas Thyroid Carcinoma AMIGO3 0.08 0.07 blup 40 0.06 1.3e-06 -4.8 -5.5 3.2e-08 0.00 0.36 0.64 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma GMPPB 0.08 0.09 lasso 8 0.09 4.3e-09 -4.9 -5.5 3.7e-08 -0.01 0.37 0.63 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma HEMK1 0.06 0.08 lasso 2 0.07 1.3e-07 -5.6 5.6 1.7e-08 -0.86 0.01 0.99 FALSE
90 The Cancer Genome Atlas Thyroid Carcinoma UBA7 0.03 0.01 blup 30 0.02 2.0e-03 -5.6 6.0 2.3e-09 -0.15 0.01 0.87 FALSE