[Hub]/) : Traits : Lung FVC : ← →

chr3:48,702,606-51,398,958

Best TWAS P=6.94e-13 · Best GWAS P=2.57e-09 conditioned to 4.9e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HEMK1	0.04	0.05	lasso	3	0.05	2.6e-06	-5.8	5.6	2.5e-08	-0.83	0.23	0.77	FALSE
2	GTEx	Adipose Subcutaneous	RNF123	0.19	0.18	enet	29	0.18	2.1e-14	-5.6	-6.0	2.7e-09	0.16	0.02	0.98	FALSE
3	GTEx	Adipose Visceral Omentum	HEMK1	0.07	0.05	lasso	3	0.04	3.2e-03	-5.6	5.6	2.5e-08	-0.86	0.15	0.56	FALSE
4	GTEx	Adipose Visceral Omentum	RNF123	0.08	0.11	lasso	4	0.07	2.2e-04	-5.6	-5.8	5.6e-09	0.18	0.03	0.97	FALSE
5	GTEx	Artery Aorta	SEMA3B-AS1	0.67	0.00	enet	61	0.12	5.0e-07	-5.3	-5.5	3.6e-08	0.42	0.04	0.70	FALSE
6	GTEx	Artery Tibial	HEMK1	0.03	0.03	enet	3	0.02	7.1e-03	-5.5	5.6	1.8e-08	-0.88	0.06	0.92	FALSE
7	GTEx	Artery Tibial	RNF123	0.08	0.08	enet	12	0.09	2.5e-07	-5.6	-6.1	8.0e-10	0.13	0.02	0.97	FALSE
8	GTEx	Brain Caudate basal ganglia	HEMK1	0.15	0.12	lasso	9	0.13	1.2e-04	-5.3	5.6	1.6e-08	-0.85	0.17	0.78	FALSE
9	GTEx	Brain Caudate basal ganglia	RNF123	0.13	0.04	enet	20	0.02	1.2e-01	-5.6	-6.1	1.3e-09	0.16	0.03	0.88	FALSE
10	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	-5.6	-5.4	7.2e-08	0.21	0.03	0.96	FALSE
11	GTEx	Brain Cerebellum	HEMK1	0.14	0.10	lasso	3	0.07	5.2e-03	-5.6	5.7	1.3e-08	-0.85	0.06	0.44	FALSE
12	GTEx	Brain Cerebellum	RNF123	0.36	0.31	enet	43	0.36	2.4e-11	-5.6	-5.5	3.4e-08	0.07	0.03	0.97	FALSE
13	GTEx	Brain Cerebellum	FAM212A	0.27	0.35	lasso	5	0.34	9.7e-11	-5.6	-5.6	2.2e-08	0.19	0.02	0.98	FALSE
14	GTEx	Brain Cortex	HEMK1	0.16	0.01	enet	19	0.03	6.1e-02	-4.8	5.4	5.1e-08	-0.81	0.05	0.58	FALSE
15	GTEx	Brain Frontal Cortex BA9	RNF123	0.25	0.28	enet	34	0.05	2.3e-02	-5.6	-5.5	3.9e-08	0.13	0.03	0.97	FALSE
16	GTEx	Breast Mammary Tissue	RNF123	0.11	0.07	enet	14	0.02	3.2e-02	-5.6	-5.5	4.2e-08	0.17	0.03	0.96	FALSE
17	GTEx	Breast Mammary Tissue (Female)	NICN1	0.01	0.00	lasso	1	0.01	1.6e-01	-5.1	5.1	3.0e-07	0.01	0.02	0.09	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	AMT	0.07	0.07	lasso	1	0.01	1.5e-01	-5.1	5.1	2.8e-07	0.06	0.16	0.23	FALSE
19	GTEx	Cells Transformed fibroblasts	UBA7	0.07	0.06	enet	5	0.04	7.5e-04	-5.5	5.5	3.5e-08	-0.20	0.03	0.97	FALSE
20	GTEx	Colon Sigmoid	HEMK1	0.08	0.08	lasso	13	0.06	2.6e-03	-4.7	5.1	2.6e-07	-0.70	0.13	0.64	FALSE
21	GTEx	Colon Sigmoid	RNF123	0.22	0.10	enet	23	0.20	1.1e-07	-4.9	-6.1	1.1e-09	0.08	0.05	0.94	FALSE
22	GTEx	Colon Transverse	C3orf18	0.04	0.01	lasso	4	0.00	1.8e-01	-5.9	-6.1	1.4e-09	0.91	0.03	0.91	FALSE
23	GTEx	Colon Transverse	RNF123	0.16	0.05	enet	36	0.05	2.3e-03	-4.8	-7.2	6.9e-13	0.08	0.13	0.55	TRUE
24	GTEx	Colon Transverse	UBA7	0.28	0.30	lasso	2	0.30	1.1e-14	-5.6	5.5	3.4e-08	-0.20	0.02	0.98	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	RNF123	0.14	0.13	enet	30	0.10	2.3e-04	-4.9	-6.0	1.7e-09	0.02	0.27	0.62	FALSE
26	GTEx	Esophagus Mucosa	UBA7	0.04	0.07	enet	8	0.05	4.5e-04	-5.5	5.3	1.0e-07	-0.19	0.03	0.96	FALSE
27	GTEx	Esophagus Mucosa	FAM212A	0.19	0.26	enet	24	0.27	4.4e-18	-5.6	-5.5	3.2e-08	0.20	0.02	0.98	FALSE
28	GTEx	Esophagus Muscularis	RASSF1	0.10	0.00	lasso	7	0.01	8.7e-02	-4.0	-6.1	1.4e-09	0.53	0.06	0.62	FALSE
29	GTEx	Esophagus Muscularis	RNF123	0.15	0.14	enet	17	0.14	1.2e-08	-5.6	-5.6	2.5e-08	0.20	0.02	0.98	FALSE
30	GTEx	Esophagus Muscularis	SEMA3B-AS1	0.47	0.00	lasso	7	0.00	5.9e-01	-6.0	-6.6	4.2e-11	0.95	0.03	0.87	TRUE
31	GTEx	Heart Atrial Appendage	HEMK1	0.15	0.10	lasso	5	0.06	1.2e-03	-5.8	6.0	1.7e-09	-0.97	0.03	0.96	FALSE
32	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	-5.5	-5.6	2.4e-08	0.19	0.05	0.86	FALSE
33	GTEx	Heart Atrial Appendage	SEMA3B-AS1	0.62	0.17	enet	83	0.32	3.8e-15	-5.8	-5.5	5.0e-08	0.50	0.02	0.98	FALSE
34	GTEx	Heart Left Ventricle	C3orf18	0.06	0.05	lasso	4	0.04	2.6e-03	-5.6	-5.5	3.5e-08	0.84	0.19	0.75	FALSE
35	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	-5.6	-6.7	2.0e-11	0.16	0.03	0.97	FALSE
36	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	4.7	-5.3	1.2e-07	0.10	0.06	0.74	FALSE
37	GTEx	Muscle Skeletal	C3orf18	0.05	0.06	enet	10	0.06	3.4e-06	-5.6	-5.8	4.9e-09	0.85	0.09	0.91	FALSE
38	GTEx	Muscle Skeletal	FAM212A	0.05	0.08	lasso	3	0.07	4.9e-07	4.8	-5.4	7.7e-08	0.19	0.12	0.88	FALSE
39	GTEx	Muscle Skeletal	SEMA3B-AS1	0.17	0.01	lasso	7	0.02	8.3e-03	-4.4	-5.3	1.2e-07	0.61	0.04	0.91	FALSE
40	GTEx	Nerve Tibial	RASSF1	0.05	0.03	enet	19	0.02	1.0e-02	-4.1	-5.9	4.3e-09	0.52	0.17	0.69	FALSE
41	GTEx	Nerve Tibial	HEMK1	0.09	0.13	lasso	7	0.12	8.3e-09	-5.6	5.6	2.2e-08	-0.85	0.15	0.85	FALSE
42	GTEx	Nerve Tibial	RNF123	0.24	0.16	lasso	5	0.15	1.0e-10	-5.5	-5.8	5.4e-09	0.18	0.03	0.97	FALSE
43	GTEx	Nerve Tibial	SEMA3B-AS1	0.25	0.04	lasso	5	0.03	3.3e-03	-5.3	-6.0	2.0e-09	0.83	0.05	0.94	FALSE
44	GTEx	Nerve Tibial	RP11-804H8.6	0.03	0.03	lasso	6	0.02	2.6e-02	-5.3	5.3	1.0e-07	-0.75	0.14	0.64	FALSE
45	GTEx	Prostate	C3orf18	0.18	0.08	lasso	9	0.11	1.1e-03	-4.5	-6.8	1.1e-11	0.61	0.09	0.61	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	UBA7	0.07	0.03	lasso	6	0.06	2.9e-04	-5.1	6.1	7.8e-10	-0.05	0.08	0.89	FALSE
47	GTEx	Skin Sun Exposed Lower leg	CYB561D2	0.13	0.02	lasso	3	0.05	5.7e-05	-5.8	6.0	2.4e-09	-0.66	0.05	0.94	FALSE
48	GTEx	Skin Sun Exposed Lower leg	RNF123	0.06	0.00	enet	22	0.01	4.6e-02	3.7	-5.9	3.2e-09	0.11	0.04	0.79	TRUE
49	GTEx	Skin Sun Exposed Lower leg	UBA7	0.04	0.01	lasso	8	0.00	2.9e-01	-5.6	6.0	1.6e-09	-0.14	0.03	0.83	FALSE
50	GTEx	Skin Sun Exposed Lower leg	FAM212A	0.05	0.07	enet	16	0.06	1.1e-05	-5.6	-5.6	2.6e-08	0.20	0.02	0.97	FALSE
51	GTEx	Spleen	RNF123	0.13	0.13	lasso	5	0.10	1.3e-03	-5.6	-5.6	2.5e-08	0.20	0.03	0.86	FALSE
52	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	-5.5	5.4	8.1e-08	-0.22	0.03	0.94	FALSE
53	GTEx	Spleen	XXcos-LUCA11.4	0.10	0.08	lasso	5	0.02	9.0e-02	-5.6	-5.7	9.2e-09	0.88	0.06	0.72	FALSE
54	GTEx	Stomach	RNF123	0.23	0.12	lasso	15	0.16	4.6e-08	-4.9	-6.1	1.2e-09	0.08	0.07	0.93	FALSE
55	GTEx	Testis	CACNA2D2	0.08	0.06	lasso	6	0.05	4.1e-03	-3.8	5.1	2.7e-07	-0.74	0.18	0.72	FALSE
56	GTEx	Thyroid	RNF123	0.09	0.13	lasso	9	0.12	2.7e-09	-5.5	-5.6	2.3e-08	0.20	0.03	0.97	FALSE
57	METSIM	Adipose	RNF123	0.03	0.02	lasso	12	0.02	2.0e-04	-5.5	-5.4	5.8e-08	0.20	0.03	0.97	FALSE
58	NTR	Blood	UBA7	0.02	0.03	lasso	4	0.03	1.6e-09	-5.5	5.3	1.3e-07	-0.20	0.03	0.97	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	C3orf18	0.03	0.00	bslmm	232	0.01	2.7e-02	-5.8	-5.2	2.5e-07	0.72	0.06	0.72	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	HEMK1	0.07	0.13	lasso	5	0.13	7.9e-16	-5.6	6.0	2.0e-09	-0.91	0.06	0.94	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	RNF123	0.04	0.05	lasso	3	0.05	1.4e-06	-5.5	-5.9	2.8e-09	0.14	0.03	0.97	FALSE
62	YFS	Blood	UBA7	0.16	0.24	lasso	6	0.23	4.0e-75	-5.6	5.6	2.5e-08	-0.20	0.03	0.97	FALSE
63	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMIGO3	0.01	0.00	enet	13	0.01	5.7e-03	-4.8	-5.7	1.2e-08	0.09	0.02	0.40	FALSE
64	The Cancer Genome Atlas	Breast Invasive Carcinoma	GMPPB	0.03	0.03	enet	12	0.03	3.0e-07	-4.8	-5.6	1.6e-08	0.03	0.36	0.64	FALSE
65	The Cancer Genome Atlas	Breast Invasive Carcinoma	HEMK1	0.02	0.02	lasso	2	0.02	1.0e-04	-5.3	5.5	3.3e-08	-0.84	0.01	0.98	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	UBA7	0.01	0.01	enet	5	0.01	6.6e-04	-5.6	5.4	8.0e-08	-0.20	0.01	0.98	FALSE
67	The Cancer Genome Atlas	Glioblastoma Multiforme	AMIGO3	0.18	0.02	enet	24	0.07	2.9e-03	-4.8	-5.7	1.4e-08	0.08	0.02	0.48	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBA7	0.02	0.02	blup	30	0.02	3.8e-03	-5.5	5.9	4.9e-09	-0.18	0.01	0.83	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf18	0.02	0.02	blup	28	0.02	8.1e-04	-5.5	-5.1	2.9e-07	0.84	0.02	0.89	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HEMK1	0.01	0.00	blup	29	0.01	1.6e-02	-5.6	5.3	9.5e-08	-0.83	0.01	0.80	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBA7	0.08	0.09	lasso	5	0.09	3.4e-10	-5.5	5.6	2.3e-08	-0.19	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBA7	0.13	0.16	lasso	6	0.15	1.1e-08	-5.6	5.6	1.6e-08	-0.20	0.01	0.99	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	GMPPB	0.15	0.12	enet	17	0.13	1.2e-14	-4.8	-5.1	2.6e-07	0.01	0.44	0.56	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	HEMK1	0.04	0.06	blup	31	0.07	4.4e-08	-5.3	5.6	2.4e-08	-0.86	0.02	0.98	FALSE
75	The Cancer Genome Atlas	Lung Adenocarcinoma	AMIGO3	0.02	0.00	blup	40	0.00	3.0e-01	-5.6	-6.2	5.8e-10	0.14	0.01	0.81	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	UBA7	0.03	0.04	enet	9	0.02	1.8e-03	-5.5	5.5	3.1e-08	-0.20	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GMPPB	0.03	0.02	enet	13	0.02	1.3e-03	-4.8	-5.5	4.1e-08	0.01	0.03	0.36	FALSE
78	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GMPPB	0.04	0.02	blup	40	0.02	1.4e-02	-5.6	-6.0	1.5e-09	0.12	0.01	0.71	FALSE
79	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UBA7	0.11	0.14	enet	7	0.11	2.7e-05	-5.5	5.5	3.6e-08	-0.21	0.01	0.98	FALSE
80	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GMPPB	0.13	0.08	blup	40	0.09	2.7e-04	-4.8	-5.6	1.7e-08	0.02	0.06	0.32	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	CACNA2D2	0.04	0.07	lasso	1	0.06	4.6e-07	-6.0	6.0	2.6e-09	-1.00	0.01	0.99	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	HEMK1	0.05	0.06	lasso	3	0.05	6.6e-06	-5.6	5.6	1.7e-08	-0.85	0.01	0.99	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	IP6K1	0.03	0.04	blup	55	0.04	9.2e-05	-5.1	-5.7	1.2e-08	0.02	0.20	0.67	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	UBA7	0.05	0.04	enet	7	0.05	1.6e-05	-5.5	6.1	1.2e-09	-0.16	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Stomach Adenocarcinoma	UBA7	0.04	0.05	lasso	1	0.04	1.0e-03	-5.5	5.5	4.4e-08	-0.20	0.01	0.95	FALSE
86	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CYB561D2	0.08	0.04	blup	17	0.08	9.3e-04	-4.3	5.3	1.1e-07	-0.59	0.01	0.42	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	AMIGO3	0.08	0.07	blup	40	0.06	1.3e-06	-4.8	-5.5	3.2e-08	0.00	0.36	0.64	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	GMPPB	0.08	0.09	lasso	8	0.09	4.3e-09	-4.9	-5.5	3.7e-08	-0.01	0.37	0.63	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	HEMK1	0.06	0.08	lasso	2	0.07	1.3e-07	-5.6	5.6	1.7e-08	-0.86	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	UBA7	0.03	0.01	blup	30	0.02	2.0e-03	-5.6	6.0	2.3e-09	-0.15	0.01	0.87	FALSE