[Hub]/) : Traits : Heel T-Score : ← →

chr11:63,316,786-66,714,782

Best TWAS P=1e-46 · Best GWAS P=3.23e-33 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NEAT1	0.07	0.02	blup	363	0.03	3.4e-04	2.589	6.2	5.0e-10	0.01	0.85	0.05	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PPP1R14B	0.10	0.09	lasso	5	0.09	1.1e-10	5.566	-6.0	1.5e-09	-0.04	0.10	0.90	FALSE
3	GTEx	Adipose Subcutaneous	LTBP3	0.12	0.09	lasso	3	0.07	1.1e-06	4.882	5.7	9.9e-09	-0.11	0.96	0.02	FALSE
4	GTEx	Adipose Subcutaneous	MAP3K11	0.08	0.12	lasso	2	0.12	7.1e-10	9.022	9.1	1.2e-19	-0.46	0.99	0.01	FALSE
5	GTEx	Adipose Visceral Omentum	MAP3K11	0.08	0.08	lasso	4	0.05	1.7e-03	10.972	10.4	2.2e-25	-0.34	0.48	0.08	FALSE
6	GTEx	Artery Aorta	MAP3K11	0.15	0.15	lasso	4	0.13	1.8e-07	11.022	10.4	3.2e-25	-0.41	0.89	0.11	FALSE
7	GTEx	Artery Tibial	MAP3K11	0.20	0.23	lasso	9	0.21	1.9e-16	9.022	8.4	3.0e-17	-0.40	1.00	0.00	FALSE
8	GTEx	Artery Tibial	PPP1R14B	0.21	0.13	lasso	4	0.13	4.0e-10	5.378	-5.6	2.2e-08	-0.04	0.40	0.60	FALSE
9	GTEx	Artery Tibial	EIF1AD	0.11	0.00	enet	26	0.01	9.4e-02	3.485	-7.8	4.3e-15	0.25	0.09	0.10	FALSE
10	GTEx	Artery Tibial	SSSCA1-AS1	0.07	0.05	lasso	3	0.04	8.0e-04	10.537	10.5	1.4e-25	-0.10	0.64	0.07	TRUE
11	GTEx	Brain Cerebellum	CCDC88B	0.48	0.55	lasso	4	0.54	1.6e-18	5.378	-5.3	1.0e-07	-0.04	0.52	0.48	FALSE
12	GTEx	Breast Mammary Tissue	LTBP3	0.08	0.01	lasso	5	0.02	5.3e-02	7.602	6.7	1.9e-11	-0.07	0.08	0.52	FALSE
13	GTEx	Breast Mammary Tissue	FIBP	0.07	0.00	lasso	4	0.01	9.7e-02	4.184	-7.7	1.2e-14	0.13	0.13	0.06	TRUE
14	GTEx	Breast Mammary Tissue	KAT5	0.15	0.06	lasso	10	0.02	2.1e-02	-9.443	-10.5	8.3e-26	0.66	0.10	0.06	FALSE
15	GTEx	Breast Mammary Tissue	MAP3K11	0.10	0.15	lasso	1	0.13	2.2e-07	9.022	9.0	1.9e-19	-0.46	0.86	0.05	FALSE
16	GTEx	Breast Mammary Tissue	RP11-867G23.1	0.21	0.02	enet	26	0.12	9.6e-07	3.136	6.9	4.2e-12	0.05	0.23	0.03	TRUE
17	GTEx	Breast Mammary Tissue (Male)	KAT5	0.05	-0.01	lasso	4	-0.01	7.4e-01	-9.457	-9.4	6.3e-21	0.61	0.03	0.09	FALSE
18	GTEx	Breast Mammary Tissue (Male)	MAP3K11	0.23	0.09	lasso	4	0.02	1.4e-01	7.494	9.0	1.6e-19	-0.32	0.09	0.07	FALSE
19	GTEx	Breast Mammary Tissue (Female)	MAP3K11	0.18	0.11	enet	29	0.08	2.6e-03	11.333	11.1	1.1e-28	-0.36	0.12	0.07	FALSE
20	GTEx	Breast Mammary Tissue (Female)	RP11-867G23.1	0.24	0.10	enet	30	0.11	4.7e-04	-4.128	5.5	4.8e-08	-0.06	0.07	0.06	TRUE
21	GTEx	Cells EBV-transformed lymphocytes	SSSCA1-AS1	0.20	0.18	lasso	3	0.09	7.3e-04	10.537	10.0	1.8e-23	-0.14	0.28	0.11	FALSE
22	GTEx	Cells Transformed fibroblasts	NAALADL1	0.08	0.04	enet	15	0.08	8.2e-07	-4.024	5.4	8.3e-08	-0.17	0.79	0.01	FALSE
23	GTEx	Cells Transformed fibroblasts	AP000769.1	0.17	0.06	lasso	6	0.05	1.6e-04	4.963	6.4	1.5e-10	-0.12	0.82	0.14	FALSE
24	GTEx	Cells Transformed fibroblasts	SIPA1	0.19	0.00	enet	30	0.05	2.5e-04	11.352	11.9	1.6e-32	-0.61	0.14	0.46	FALSE
25	GTEx	Colon Sigmoid	MAP3K11	0.23	0.05	enet	8	0.08	6.5e-04	11.405	10.2	2.0e-24	-0.29	0.54	0.15	FALSE
26	GTEx	Colon Transverse	DPF2	0.19	0.01	lasso	4	0.05	1.6e-03	6.292	9.5	1.5e-21	-0.41	0.07	0.32	FALSE
27	GTEx	Colon Transverse	MAP3K11	0.19	0.18	lasso	5	0.17	2.4e-08	9.022	9.0	2.7e-19	-0.44	0.93	0.05	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	MAP3K11	0.31	0.27	enet	42	0.26	4.9e-10	9.082	5.3	1.2e-07	-0.22	0.94	0.04	TRUE
29	GTEx	Esophagus Mucosa	DPF2	0.12	0.02	lasso	4	0.03	6.2e-03	-3.757	5.2	1.6e-07	-0.34	0.10	0.21	FALSE
30	GTEx	Esophagus Mucosa	PLCB3	0.28	0.24	lasso	6	0.23	1.1e-15	-5.049	5.8	7.2e-09	0.07	0.84	0.16	FALSE
31	GTEx	Esophagus Mucosa	SIPA1	0.34	0.17	lasso	6	0.20	1.6e-13	-12.008	8.9	7.2e-19	-0.91	0.00	1.00	FALSE
32	GTEx	Esophagus Muscularis	CCDC88B	0.09	0.00	lasso	3	0.06	1.1e-04	-3.310	-5.3	1.2e-07	-0.07	0.12	0.26	FALSE
33	GTEx	Esophagus Muscularis	MAP3K11	0.19	0.20	lasso	7	0.20	4.9e-12	9.022	9.4	4.4e-21	-0.47	0.99	0.01	FALSE
34	GTEx	Esophagus Muscularis	KCNK7	0.17	0.02	enet	27	0.10	6.5e-07	3.823	-7.9	2.7e-15	0.27	0.28	0.21	FALSE
35	GTEx	Heart Atrial Appendage	RP11-755F10.1	0.16	0.11	enet	15	0.09	9.1e-05	2.914	5.7	1.6e-08	-0.17	0.61	0.04	FALSE
36	GTEx	Lung	MAP3K11	0.08	0.08	lasso	5	0.07	4.4e-06	9.082	9.1	1.0e-19	-0.45	0.83	0.08	FALSE
37	GTEx	Nerve Tibial	LTBP3	0.12	0.05	lasso	3	0.09	1.2e-06	4.947	9.1	9.6e-20	-0.17	0.05	0.94	FALSE
38	GTEx	Nerve Tibial	MAP3K11	0.11	0.16	lasso	1	0.15	9.4e-11	9.022	9.0	1.9e-19	-0.46	1.00	0.00	FALSE
39	GTEx	Nerve Tibial	AP000769.1	0.05	0.03	lasso	5	0.03	2.1e-03	10.449	6.6	4.7e-11	-0.01	0.19	0.12	TRUE
40	GTEx	Nerve Tibial	SIPA1	0.17	0.01	enet	19	0.06	6.8e-05	-6.042	8.5	1.3e-17	-0.55	0.08	0.77	FALSE
41	GTEx	Nerve Tibial	RP11-867G23.1	0.15	0.05	lasso	3	0.04	1.2e-03	-6.974	6.8	1.3e-11	-0.19	0.35	0.04	TRUE
42	GTEx	Pancreas	MAP3K11	0.15	0.16	lasso	3	0.11	1.6e-05	9.082	9.0	3.2e-19	-0.44	0.62	0.05	FALSE
43	GTEx	Prostate	MAP3K11	0.27	0.24	lasso	2	0.21	4.6e-06	9.022	9.1	1.3e-19	-0.46	0.15	0.58	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K11	0.07	0.08	lasso	3	0.07	7.6e-05	7.494	7.9	2.2e-15	-0.40	0.49	0.12	FALSE
45	GTEx	Skin Sun Exposed Lower leg	MAP3K11	0.08	0.07	lasso	3	0.06	6.0e-06	9.022	8.9	4.2e-19	-0.45	0.72	0.04	FALSE
46	GTEx	Spleen	MAP3K11	0.34	0.38	lasso	5	0.38	1.0e-10	9.022	9.1	6.2e-20	-0.42	0.88	0.04	FALSE
47	GTEx	Stomach	MAP3K11	0.09	0.02	lasso	3	0.04	4.4e-03	9.082	7.8	8.4e-15	-0.40	0.18	0.13	FALSE
48	GTEx	Thyroid	MAP3K11	0.20	0.19	lasso	8	0.21	4.4e-16	9.022	9.0	3.0e-19	-0.44	0.99	0.01	FALSE
49	GTEx	Thyroid	PCNXL3	0.07	0.05	lasso	4	0.03	2.2e-03	11.022	9.1	7.6e-20	-0.26	0.38	0.08	TRUE
50	GTEx	Uterus	PACS1	0.21	-0.01	enet	21	0.05	3.6e-02	2.670	-5.4	8.3e-08	0.15	0.09	0.05	FALSE
51	GTEx	Whole Blood	MAP3K11	0.12	0.07	lasso	6	0.08	1.1e-07	9.082	8.8	2.0e-18	-0.42	0.98	0.01	FALSE
52	METSIM	Adipose	BANF1	0.10	0.06	bslmm	343	0.07	4.9e-10	-2.790	6.7	1.9e-11	-0.31	1.00	0.00	FALSE
53	METSIM	Adipose	FIBP	0.05	0.02	blup	344	0.02	1.0e-03	1.965	5.2	2.5e-07	-0.20	0.96	0.00	FALSE
54	METSIM	Adipose	LTBP3	0.03	0.00	bslmm	369	0.01	1.5e-02	0.512	5.6	2.3e-08	-0.33	0.09	0.12	FALSE
55	METSIM	Adipose	MAP3K11	0.22	0.26	lasso	10	0.26	1.4e-38	9.022	8.9	4.9e-19	-0.44	1.00	0.00	FALSE
56	METSIM	Adipose	RNASEH2C	0.07	0.03	blup	325	0.04	3.4e-07	0.025	-9.1	1.4e-19	0.44	0.72	0.17	FALSE
57	METSIM	Adipose	SART1	0.08	0.05	enet	26	0.05	1.1e-07	-2.696	7.8	4.0e-15	-0.26	1.00	0.00	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	POLA2	0.04	0.04	bslmm	339	0.03	4.6e-05	-3.311	5.5	3.1e-08	-0.16	0.98	0.00	TRUE
59	ROSMAP	Brain Pre-frontal Cortex	CCDC88B	0.33	0.39	lasso	9	0.40	1.1e-54	5.184	-5.5	4.8e-08	-0.05	0.34	0.66	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	CTSW	0.06	0.03	bslmm	328	0.03	3.6e-05	1.806	-7.6	3.1e-14	0.36	0.39	0.36	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	OVOL1	0.16	0.24	lasso	2	0.24	1.3e-30	10.972	10.9	8.1e-28	-0.35	1.00	0.00	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	PPP1R14B	0.12	0.13	lasso	7	0.12	2.4e-15	5.483	-6.3	3.9e-10	-0.04	0.31	0.69	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	BANF1	0.05	0.02	blup	325	0.03	2.4e-04	-3.284	5.1	3.0e-07	-0.12	0.66	0.02	TRUE
64	ROSMAP	Brain Pre-frontal Cortex	KCNK4	0.14	0.12	bslmm	334	0.11	3.0e-14	-5.138	-5.8	8.0e-09	-0.08	0.84	0.16	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	TEX40	0.25	0.23	lasso	3	0.23	2.5e-29	-5.010	5.2	1.8e-07	0.08	0.86	0.14	FALSE
66	YFS	Blood	FIBP	0.04	0.02	bslmm	343	0.03	6.4e-09	1.948	7.7	1.1e-14	-0.26	1.00	0.00	FALSE
67	YFS	Blood	TM7SF2	0.07	0.04	bslmm	328	0.06	1.6e-17	3.462	-7.5	8.5e-14	0.16	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNASEH2C	0.05	0.00	blup	32	0.02	1.1e-04	0.026	-9.9	4.8e-23	0.71	0.03	0.02	FALSE
69	The Cancer Genome Atlas	Colon Adenocarcinoma	LTBP3	0.07	0.04	lasso	3	0.02	2.2e-02	4.947	-5.8	7.6e-09	0.16	0.02	0.28	TRUE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SIPA1	0.06	0.04	blup	43	0.05	4.6e-06	-9.693	13.4	7.8e-41	-0.86	0.01	0.98	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KCNK7	0.04	0.01	blup	42	0.01	1.2e-02	4.947	-6.9	5.0e-12	0.52	0.13	0.71	TRUE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP3K11	0.06	0.03	lasso	4	0.03	2.1e-04	-9.693	11.3	9.7e-30	-0.71	0.02	0.76	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RNASEH2C	0.15	0.05	blup	32	0.05	3.1e-06	0.026	-7.4	1.4e-13	0.62	0.62	0.02	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SIPA1	0.04	0.00	blup	43	0.02	6.2e-03	-12.008	14.4	1.0e-46	-0.80	0.00	0.70	TRUE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BAD	0.09	0.05	enet	4	0.07	7.7e-05	-3.209	-6.0	2.5e-09	-0.06	0.00	0.83	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	OVOL1	0.03	0.03	blup	36	0.02	8.3e-04	10.972	8.9	4.9e-19	-0.25	0.00	0.99	FALSE
77	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SIPA1	0.09	0.03	blup	43	0.06	1.2e-07	-12.008	9.8	1.7e-22	-0.82	0.00	1.00	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf20	0.07	0.03	enet	10	0.05	3.8e-06	-5.049	7.0	2.9e-12	0.06	0.11	0.81	TRUE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	KCNK7	0.04	0.02	blup	42	0.03	3.1e-04	3.836	-7.0	2.0e-12	0.16	0.13	0.03	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	MAP3K11	0.06	0.02	blup	47	0.03	1.4e-04	-12.008	8.3	6.7e-17	-0.76	0.00	0.98	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	NAALADL1	0.04	0.02	blup	45	0.02	2.0e-03	-4.400	5.2	2.6e-07	-0.11	0.00	0.33	FALSE
82	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SNX32	0.51	0.26	blup	60	0.36	1.9e-10	1.379	5.5	3.1e-08	-0.27	0.68	0.09	FALSE
83	The Cancer Genome Atlas	Stomach Adenocarcinoma	NEAT1	0.09	0.06	enet	6	0.09	5.8e-07	5.793	7.9	3.3e-15	-0.11	0.01	0.99	FALSE
84	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RNASEH2C	0.10	0.01	blup	32	0.05	7.9e-03	-1.918	-7.6	3.4e-14	0.04	0.01	0.30	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	DPF2	0.05	0.02	blup	29	0.03	3.7e-04	-2.031	5.2	2.0e-07	-0.20	0.08	0.15	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K11	0.04	0.04	lasso	2	0.03	6.9e-04	9.082	9.6	7.3e-22	-0.50	0.07	0.27	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	NAALADL1	0.05	0.00	blup	44	0.02	1.8e-03	-4.418	5.5	3.6e-08	-0.18	0.00	0.25	FALSE