[Hub]/) : Traits : Heel T-Score : ← →

chr19:17,094,824-20,163,633

Best TWAS P=3.18e-22 · Best GWAS P=9.98e-22 conditioned to 5.63e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Tibial	SSBP4	0.09	0.04	lasso	5	0.00	3.0e-01	7.3	-7.3	4.0e-13	-0.09	0.48	0.18	FALSE
2	GTEx	Brain Hippocampus	DDX49	0.23	-0.01	lasso	4	-0.01	6.6e-01	5.6	-6.2	6.3e-10	-0.01	0.05	0.07	TRUE
3	GTEx	Brain Nucleus accumbens basal ganglia	ELL	0.17	0.00	lasso	5	0.01	2.1e-01	7.4	-7.0	3.4e-12	-0.07	0.13	0.06	FALSE
4	GTEx	Cells Transformed fibroblasts	SSBP4	0.09	0.07	lasso	2	0.06	5.5e-05	7.2	-7.3	3.5e-13	-0.07	0.86	0.01	FALSE
5	GTEx	Esophagus Mucosa	SSBP4	0.14	0.10	lasso	2	0.14	1.3e-09	7.4	-6.7	2.3e-11	-0.05	1.00	0.00	FALSE
6	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	6.0	-5.6	1.8e-08	0.05	0.02	0.98	FALSE
7	GTEx	Muscle Skeletal	SSBP4	0.09	0.07	lasso	3	0.07	1.3e-07	7.3	-7.5	7.2e-14	-0.10	1.00	0.00	FALSE
8	GTEx	Skin Sun Exposed Lower leg	SSBP4	0.12	0.12	lasso	3	0.11	2.9e-09	7.4	-7.4	1.8e-13	-0.08	1.00	0.00	FALSE
9	GTEx	Thyroid	ARRDC2	0.14	0.01	enet	5	0.01	2.7e-02	7.3	-7.7	1.2e-14	-0.45	0.19	0.07	TRUE
10	GTEx	Thyroid	SSBP4	0.09	0.11	lasso	6	0.10	8.2e-08	7.3	-7.1	1.3e-12	-0.06	1.00	0.00	FALSE
11	GTEx	Whole Blood	ELL	0.10	0.03	enet	17	0.04	1.2e-04	7.3	6.8	8.4e-12	0.08	0.81	0.01	FALSE
12	GTEx	Whole Blood	LRRC25	0.12	0.01	enet	7	0.02	1.0e-02	7.2	-6.4	2.1e-10	-0.02	0.59	0.02	FALSE
13	METSIM	Adipose	ELL	0.08	0.05	lasso	7	0.06	7.1e-09	7.5	8.0	1.2e-15	0.08	1.00	0.00	TRUE
14	METSIM	Adipose	IL12RB1	0.05	0.05	lasso	3	0.04	2.8e-07	-4.7	5.2	1.6e-07	0.16	1.00	0.00	FALSE
15	METSIM	Adipose	LRRC25	0.04	0.01	bslmm	385	0.01	2.8e-02	6.7	-6.5	8.2e-11	-0.01	0.13	0.03	FALSE
16	NTR	Blood	LRRC25	0.03	0.01	lasso	4	0.01	2.9e-04	6.7	-5.3	1.4e-07	-0.06	0.37	0.18	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	ELL	0.27	0.39	lasso	7	0.39	4.0e-53	7.6	-7.6	3.3e-14	-0.07	1.00	0.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	LRRC25	0.09	0.02	blup	383	0.07	7.4e-09	1.1	-6.0	2.4e-09	0.07	0.96	0.00	FALSE
19	YFS	Blood	ELL	0.23	0.41	enet	24	0.43	2.6e-158	7.2	6.0	2.2e-09	0.07	0.86	0.14	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ARRDC2	0.05	0.02	blup	46	0.02	5.0e-03	2.7	-5.6	1.9e-08	-0.03	0.06	0.04	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	IL12RB1	0.06	0.03	lasso	5	0.05	3.9e-10	-7.5	7.3	3.3e-13	0.27	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	LRRC25	0.06	0.07	enet	13	0.06	5.9e-13	6.5	-6.9	5.6e-12	-0.04	0.92	0.08	FALSE
23	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LRRC25	0.14	0.07	enet	5	0.10	8.3e-06	6.7	-6.2	4.0e-10	-0.01	0.13	0.23	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC25	0.06	0.05	blup	44	0.04	1.5e-03	7.3	-6.0	1.8e-09	-0.08	0.01	0.92	FALSE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	SSBP4	0.08	0.05	enet	9	0.07	6.7e-05	7.8	-6.1	1.1e-09	-0.01	0.01	0.97	FALSE
26	The Cancer Genome Atlas	Glioblastoma Multiforme	ELL	0.13	0.10	blup	46	0.08	1.9e-03	7.6	-7.9	3.5e-15	-0.06	0.02	0.87	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL12RB1	0.05	0.03	enet	11	0.05	2.3e-06	6.2	6.4	1.6e-10	0.22	0.68	0.16	FALSE
28	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SSBP4	0.04	0.03	blup	37	0.04	1.6e-05	7.6	-7.9	3.1e-15	-0.07	0.01	0.99	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL12RB1	0.10	0.08	blup	58	0.09	6.9e-10	-4.5	8.0	1.2e-15	0.28	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	-2.8	5.2	1.8e-07	0.16	0.01	0.14	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SSBP4	0.02	0.02	blup	37	0.03	3.7e-04	7.2	-5.6	2.2e-08	-0.03	0.02	0.88	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TM6SF2	0.04	0.03	blup	35	0.03	2.5e-04	5.8	5.9	3.4e-09	-0.04	0.01	0.98	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C19orf50	0.12	0.00	enet	11	0.01	6.5e-02	1.1	-5.5	4.8e-08	0.00	0.01	0.59	FALSE
34	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SSBP4	0.06	0.07	enet	6	0.07	5.6e-05	7.2	-6.7	1.9e-11	-0.04	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	IL12RB1	0.05	0.03	lasso	3	0.03	1.3e-04	-4.7	6.2	4.2e-10	0.18	0.32	0.22	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC25	0.07	0.08	blup	46	0.09	2.2e-10	6.5	-6.7	2.3e-11	-0.03	0.26	0.74	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	SSBP4	0.03	0.03	lasso	1	0.03	9.7e-05	6.5	-6.5	8.9e-11	-0.05	0.15	0.63	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	ARRDC2	0.04	0.01	enet	7	0.03	5.3e-04	-7.5	-9.7	3.2e-22	-0.18	0.02	0.05	TRUE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	IL12RB1	0.10	0.08	enet	13	0.07	3.9e-08	-4.5	6.6	3.2e-11	0.19	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	LRRC25	0.04	0.01	blup	45	0.02	6.2e-04	6.5	-7.7	1.6e-14	-0.06	0.02	0.95	TRUE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C19orf62	0.03	0.01	blup	60	0.01	1.9e-02	4.1	-5.1	2.9e-07	-0.10	0.00	0.16	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	-2.9	7.3	2.5e-13	0.31	0.89	0.09	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LRRC25	0.06	0.02	blup	46	0.04	5.6e-05	6.7	-5.5	2.9e-08	-0.07	0.02	0.95	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LRRC25	0.07	0.03	blup	46	0.02	8.5e-03	6.7	-7.9	3.6e-15	-0.08	0.02	0.75	FALSE
45	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SSBP4	0.06	0.02	blup	37	0.05	4.3e-04	7.6	-5.7	1.4e-08	-0.10	0.01	0.92	TRUE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LRRC25	0.12	0.03	blup	45	0.01	1.1e-01	6.5	-7.7	2.0e-14	-0.08	0.01	0.22	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	ELL	0.03	0.03	blup	47	0.01	1.2e-02	7.6	-7.2	4.8e-13	-0.04	0.01	0.94	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	IL12RB1	0.09	0.01	blup	58	0.05	1.2e-05	-4.7	6.3	2.9e-10	0.28	0.88	0.01	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	SSBP4	0.04	0.08	enet	13	0.08	8.4e-09	7.8	-7.3	3.9e-13	-0.06	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Stomach Adenocarcinoma	OCEL1	0.18	0.08	blup	53	0.11	1.4e-08	4.1	5.4	5.3e-08	0.04	0.00	0.81	TRUE
51	The Cancer Genome Atlas	Stomach Adenocarcinoma	SSBP4	0.05	0.00	blup	37	0.02	8.7e-03	4.0	-6.1	9.9e-10	-0.05	0.02	0.18	FALSE
52	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	-7.5	5.4	6.2e-08	0.23	0.03	0.12	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	ELL	0.06	0.06	blup	46	0.09	1.2e-08	7.5	-7.1	1.7e-12	-0.03	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	ISYNA1	0.04	0.00	blup	34	0.02	4.8e-03	4.0	6.6	3.5e-11	0.07	0.02	0.85	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	LRRC25	0.05	0.08	lasso	3	0.07	5.4e-07	6.7	-7.0	3.4e-12	-0.04	0.06	0.94	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	TM6SF2	0.05	0.04	blup	34	0.05	2.8e-05	5.8	5.8	7.0e-09	-0.03	0.01	0.99	FALSE