TWAS hub - ISYNA1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.049	0.030	0.00980	0.026	0.019	0.027	NA	0.017	2.6e-03	0.00880	2.3e-03	NA	1.2e-02
2	TCGA	Colon Adenocarcinoma	0.081	0.044	0.00020	0.092	0.057	0.083	NA	0.090	5.7e-06	0.00031	1.5e-05	NA	7.0e-06
3	TCGA	Stomach Adenocarcinoma	0.050	0.030	0.00042	0.042	0.044	0.051	NA	0.033	5.1e-04	0.00037	1.4e-04	NA	2.0e-03
4	TCGA	Thyroid Carcinoma	0.044	0.030	0.00044	-0.001	0.019	-0.001	NA	0.008	4.1e-01	0.00480	4.8e-01	NA	5.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Breast Cancer	26.4	63.6	102.0	4.5	7.9	8.4	10.1
Family relationship satisfaction	9.7	11.9	15.3	-3.9	-3.4	-3.2	-3.2
Supplements: Glucosamine	6.2	8.0	12.0	-2.4	-2.6	-3.5	-2.7
Ever had prostate specific antigen (PSA) test	5.5	6.4	9.6	-1.1	-3.1	-2.5	-2.9
Medication: Atorvastatin	5.3	6.6	8.7	2.4	2.4	3.0	2.5
Number of operations (self-reported)	5.1	7.6	12.1	2.9	1.8	3.5	2.6
Allergy or Eczema	4.7	12.4	23.9	-3.4	-2.1	-4.9	-3.1
Hayfever, allergic rhinitis or eczema	4.2	9.1	17.1	-2.5	-2.1	-4.1	-2.9
Frequency of tiredness / lethargy in last 2 weeks	4.0	6.5	14.7	-0.4	-2.0	-2.7	-3.8
Friendships satisfaction	3.9	4.8	7.2	-1.0	-2.6	-2.1	-2.7
Pulse wave peak to peak time	3.7	4.3	9.8	-1.5	-1.1	-3.1	-2.0
Stomach or abdominal pain in last month	3.6	4.4	6.4	-1.1	-2.4	-2.0	-2.5
Nervous feelings	3.6	6.7	12.6	-1.0	-2.5	-2.6	-3.5
Number of children fathered	3.5	3.9	6.6	0.5	2.4	1.8	2.6
Angina (self-reported)	3.4	4.5	6.5	2.5	1.5	2.5	1.7
Medication: Omeprazole	3.4	4.1	7.4	-0.5	-2.7	-1.8	-2.4
Waist Hip Ratio (WHR)	3.3	14.8	27.8	-3.0	-5.3	-3.2	-3.5
Hayfever/allergic rhinitis (self-reported)	3.2	4.2	6.3	-2.0	-1.6	-2.5	-1.9
Number of live births	3.2	4.6	7.2	-1.1	-1.7	-2.7	-2.7
Mouth/teeth dental problems: Mouth ulcers	3.2	5.0	6.7	-2.6	-2.5	-2.6	-0.5
Qualifications: None of the above	3.1	6.7	8.0	2.2	2.5	2.8	2.8
Angina	3.0	3.9	6.1	2.5	1.4	2.3	1.5
Hearing difficulty/problems with background noise	3.0	4.8	8.0	-0.3	-2.8	-2.1	-2.6
Noisy workplace	3.0	3.7	5.5	1.6	1.4	2.3	2.2
LDL Cholesterol	2.8	4.4	6.2	1.1	2.2	2.4	2.5
Impedance of leg (left)	2.8	13.7	26.4	-5.1	-2.7	-4.1	-2.0
Impedance of leg (right)	2.7	13.3	30.0	-5.5	-2.3	-4.1	-1.2
Happiness	2.7	3.2	5.1	-1.6	-2.0	-1.1	-2.2
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	6.2	0.2	-2.5	-1.1	-2.4
Lupus	2.6	3.9	6.9	-0.5	-1.4	-2.6	-2.5
Blood Red Count	2.6	25.4	46.5	-0.7	6.8	3.4	6.6
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.3	7.2	0.2	-1.8	-1.7	-2.7
Overall health rating	2.4	5.3	11.6	0.9	-2.8	-1.0	-3.4
Health satisfaction	2.3	3.0	5.6	-0.7	-2.1	-1.3	-2.4
Heel T-Score	2.2	17.9	43.8	1.5	4.0	3.1	6.6
Smoking Status	2.2	5.3	7.7	2.8	2.0	2.7	1.6
Illnesses of siblings: Diabetes	2.2	2.7	3.8	-0.8	-1.9	-1.7	-1.8
Medication: Aspirin	2.1	2.8	3.6	1.8	1.2	1.9	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	6.7	2.6	-1.2	0.6	-1.2
Lung FVC	2.0	10.3	20.4	-0.0	4.3	1.6	4.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	6.2	0.7	-1.7	-1.1	-2.5
Qualifications: CSEs or equivalent	2.0	2.6	5.0	1.3	1.4	2.2	1.3
Past tobacco smoking	2.0	3.6	5.1	-1.6	-2.0	-1.8	-2.2
Pulse wave Arterial Stiffness index	2.0	2.3	6.2	1.1	0.6	2.5	1.3
Long-standing illness, disability or infirmity	2.0	3.0	6.8	0.3	-2.0	-1.0	-2.6
Qualifications: nursing, teaching	2.0	3.2	6.0	-0.1	-2.5	-1.9	-1.8
Worry (Nagel 2018)	1.9	4.0	8.5	-0.4	-1.7	-2.1	-2.9
Ulcerative Colitis (UC)	1.9	3.5	7.3	-1.4	-2.7	-1.2	-1.8
Mean Putamen Volume	1.9	2.1	3.8	0.4	-2.0	-1.4	-1.6
Height	1.9	36.9	51.4	-5.2	-5.0	-6.7	-7.2
Frequency of depressed mood in last 2 weeks	1.9	2.6	5.0	-0.1	-1.9	-1.4	-2.2
Suffer from ‘nerves’	1.9	3.0	7.7	-0.0	-1.3	-1.6	-2.8
Crohns Disease (2012)	1.8	2.9	5.8	2.1	0.7	2.4	1.0
Neuroticism	1.8	4.3	8.2	-0.2	-2.1	-2.1	-2.9
Medication: Atenolol	1.8	2.3	5.3	2.3	0.3	1.9	0.3
Pulse wave reflection index	1.8	2.2	5.1	0.9	1.0	2.3	1.4
Smoking status: Previous	1.8	2.6	3.7	1.3	1.4	1.7	1.9
Intelligence (Savage-Jansen 2018)	1.7	5.3	8.0	-2.0	-2.8	-2.3	-2.0
Schizophrenia (2014)	1.7	3.7	7.3	0.0	-2.3	-1.5	-2.7
Fed-up feelings	1.7	3.0	7.3	1.3	-1.4	-1.1	-2.7
Arm fat percentage (right)	1.7	6.5	15.9	4.0	0.8	3.0	0.8
Medication: Lansoprazole	1.7	1.9	3.3	1.7	1.0	1.8	0.5
Standing height	1.7	16.4	24.0	-3.1	-3.4	-4.6	-4.9
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	6.7	2.6	0.1	1.4	0.5
Had major operations	1.7	2.0	4.7	2.2	0.4	1.7	0.7
Medication: Paracetamol	1.7	2.6	3.7	-1.6	-1.3	-1.6	-1.9
Crohns Disease (2017)	1.6	3.5	5.8	0.7	1.6	2.3	2.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	2.6	1.6	1.2	1.5	1.1
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	5.3	-0.2	-1.8	-1.2	-2.3
Comparative body size at age 10	1.6	4.5	15.1	3.9	0.5	1.6	0.3
Bipolar Disorder or Schizophrenia	1.5	3.6	8.2	-0.0	-1.8	-1.7	-2.9
Neuroticism (Nagel 2018)	1.5	3.4	7.3	0.2	-1.8	-1.8	-2.7
Body Mass Index (BMI) (2010)	1.5	2.0	4.6	2.2	0.6	1.5	0.8
Medication: Blood pressure	1.5	2.7	7.4	2.7	-0.1	1.8	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.7	2.7	1.6	1.4	1.1	1.1
Arm fat percentage (left)	1.5	5.8	15.3	3.9	0.6	2.7	0.6
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	3.5	0.1	-1.3	-1.2	-1.9
Allergy	1.4	3.2	5.0	1.5	1.4	2.2	1.8
Exposure to tobacco smoke outside home	1.4	1.9	3.0	-0.6	-1.2	-1.7	-1.7
Migraine (self-reported)	1.4	1.7	3.5	0.1	1.7	0.9	1.9
Age at last live birth	1.4	2.0	3.0	-1.1	-1.4	-1.7	-1.3
Depressed Affect (Nagel 2018)	1.3	2.8	6.0	0.2	-1.5	-1.8	-2.4
Depression (Nagel 2018)	1.3	2.0	4.0	-0.0	-1.6	-1.2	-2.0
Alzheimer’s Disease (including proxy)	1.3	1.9	5.0	1.3	0.2	2.2	0.9
Ever had hysterectomy (womb removed)	1.3	1.5	3.4	0.2	1.0	1.2	1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	4.9	1.5	1.8	1.3	2.2
Sitting height	1.3	9.0	12.5	-2.4	-2.3	-3.5	-3.5
Qualifications: A levels/AS levels or equivalent	1.3	3.0	4.3	-1.8	-1.5	-2.1	-1.5
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	5.9	-2.4	0.3	-1.4	-0.7
Comparative height size at age 10	1.3	7.3	10.7	-1.6	-2.9	-2.7	-3.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	4.5	-1.5	-1.1	-1.7	-2.1
Commuting to job workplace: Public transport	1.3	1.5	2.8	-1.7	-0.5	-1.6	-0.8
Cholesterol lowering medication	1.3	1.9	4.3	-0.0	1.3	1.3	2.1
Heart disease (siblings)	1.3	1.6	2.8	0.8	1.1	1.7	1.2
Primary Biliary Cirrhosis	1.2	1.7	2.4	-0.6	-1.6	-1.4	-1.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.2	0.7	1.5	0.8	1.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.4	-1.9	0.5	-1.2	-0.1
Body mass index (BMI)	1.2	5.1	14.9	3.9	0.5	2.3	0.0
Falls in the last year	1.2	1.6	2.3	1.4	1.5	1.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.0	-0.7	-0.7	-1.1	-1.7
Peak expiratory flow (PEF)	1.2	2.7	5.5	-0.5	2.4	0.3	2.2
Qualifications: College or University degree	1.2	3.9	6.0	-1.8	-1.6	-2.4	-1.9
Mean time to correctly identify matches	1.2	2.2	4.5	0.7	-1.7	-1.1	-2.1
Chest pain or discomfort	1.2	1.7	4.1	0.8	-1.3	-0.6	-2.0
Eye problems/disorders: Cataract	1.2	1.4	2.7	-0.9	-1.6	-0.8	-1.1
Schizophrenia (2018)	1.1	2.2	4.5	0.1	-1.4	-1.5	-2.1
Schizophrenia vs Biploar Disorder	1.1	1.5	2.8	0.0	-1.7	-1.4	-1.0
Relative age of first facial hair	1.1	2.3	3.0	0.9	1.7	1.6	1.7
Father’s age at death	1.1	1.5	4.1	-2.0	0.4	-1.0	0.9
Length of working week for main job	1.1	1.3	4.0	2.0	-0.3	0.9	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.2	1.5	-0.9	-0.1	-1.4
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.1	1.3	0.8	1.4	0.9
Mood swings	1.1	2.0	5.3	2.3	-0.1	0.2	-1.6
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.7	1.6	0.3	1.6	0.4
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.2	1.1	0.8	1.6	1.8
Current tobacco smoking	1.0	1.6	3.3	1.8	1.2	1.3	0.5
Heart attack	1.0	1.3	3.0	1.7	0.2	1.5	0.2
Lung cancer (father)	1.0	1.1	2.6	-1.6	-0.7	-1.2	-0.1
Medication: Paracetamol	1.0	1.6	2.8	-0.9	-1.0	-1.3	-1.7
Medication: Ibuprofen	1.0	1.2	2.4	1.6	-0.2	0.1	-1.5
Commuting to job workplace: Walk	1.0	1.1	2.2	-1.5	-0.1	-1.4	-0.3
Breast cancer (self-reported)	1.0	1.2	3.2	-0.5	-0.8	-0.8	-1.8
Arm fat mass (left)	1.0	3.9	12.3	3.5	-0.0	1.7	-0.6
Miserableness	1.0	1.8	3.9	1.2	-0.7	-1.1	-2.0
Bipolar Disorder (2018)	0.9	1.3	3.6	0.3	-1.1	-0.7	-1.9
Rheumatoid Arthritis	0.9	1.3	2.8	-0.9	-0.9	-1.7	-0.8
Lung FEV1/FVC ratio	0.9	4.7	8.6	-1.4	-1.4	-2.9	-2.5
Chronotype (morning person)	0.9	2.2	5.0	1.6	-1.0	-0.5	-2.2
Average weekly spirits intake	0.9	1.1	3.3	0.0	0.2	1.8	0.9
Townsend deprivation index at recruitment	0.9	1.3	3.4	1.9	0.4	1.2	0.4
Neuroticism score	0.9	2.0	4.4	0.5	-1.0	-1.5	-2.1
Hair/balding pattern: Pattern 3	0.9	1.4	2.4	0.3	1.5	1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.4	1.9	0.1	0.7	-0.9
Arm fat mass (right)	0.9	3.5	10.7	3.3	-0.1	1.7	-0.5
Exposure to tobacco smoke at home	0.9	1.0	1.8	1.3	-0.8	-0.2	-1.3
High blood pressure (siblings)	0.9	1.4	4.1	2.0	-0.8	0.4	-0.7
Arm predicted mass (right)	0.9	4.5	12.1	0.7	-1.7	-1.7	-3.5
Smoking status: Current	0.9	1.4	3.3	1.8	1.0	1.0	0.3
Number of self-reported non-cancer illnesses	0.9	1.6	3.8	1.3	0.3	2.0	0.8
Wears glasses or contact lenses	0.9	1.0	1.7	-0.7	-1.1	-1.3	-0.8
Ever smoked	0.9	1.6	2.3	1.5	1.4	0.9	1.1
Age started oral contraceptive pill	0.9	1.2	2.4	0.4	-1.5	0.3	-1.5
Alzheimer’s Disease (in father)	0.8	0.9	1.5	1.2	-0.0	0.8	-1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	2.7	-0.9	-1.6	-1.6	-1.3
Fasting Glucose	0.8	1.0	3.2	-1.8	-0.4	-0.6	0.6
HDL Cholesterol	0.8	1.3	3.1	0.1	1.8	0.5	1.3
Ulcerative Colitis	0.8	1.2	2.8	-0.9	-1.7	-0.7	-0.7
Blood White Count	0.8	6.3	19.4	0.9	0.4	4.4	2.2
Respiratory disease	0.8	1.9	2.8	1.3	1.5	1.7	0.8
Systolic blood pressure, automated reading	0.8	2.3	6.2	0.9	-1.3	-0.5	-2.5
Maternal smoking around birth	0.8	1.1	2.5	0.4	0.5	1.6	1.2
Age when periods started (menarche)	0.8	2.0	3.7	-0.2	1.9	1.0	1.8
Alcohol usually taken with meals	0.8	1.4	3.4	0.2	-1.9	-0.2	-1.4
Financial difficulties in last 2 years	0.8	1.0	2.2	0.8	-0.7	-0.9	-1.5
Illnesses of siblings	0.8	1.1	2.4	-1.6	1.0	0.1	1.0
Depression (self-reported)	0.8	0.9	1.6	1.3	0.9	1.1	0.5
Glaucoma (self-reported)	0.8	0.9	1.4	0.8	1.2	0.9	0.9
Osteoporosis (self-reported)	0.8	1.0	2.8	-0.4	-0.8	-0.7	-1.7
Medication: Aspirin	0.8	1.1	1.7	0.9	0.6	1.2	1.3
Impedance of whole body	0.8	4.3	12.2	-3.5	-1.2	-1.9	-0.1
Neuroticism (2016)	0.7	1.0	2.5	1.6	-0.6	0.4	-1.0
Trunk fat percentage	0.7	2.9	8.1	2.8	-0.9	1.3	-1.0
Taking other prescription medications	0.7	1.0	2.7	1.6	-0.3	1.1	-0.4
Trunk fat mass	0.7	3.1	7.7	2.8	-1.1	0.9	-1.6
Waist circumference	0.7	2.6	3.8	2.0	-1.8	0.3	-1.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	4.5	-2.1	1.4	-1.5	0.9
Pulse rate	0.7	1.1	3.2	-1.8	-0.1	-1.0	0.5
Asthma	0.7	1.4	3.0	1.1	0.9	1.7	0.6
Birth weight	0.7	1.4	3.5	-1.9	-0.2	-1.4	-0.7
Body fat percentage	0.7	2.6	7.6	2.8	-0.7	1.3	-0.8
Arm fat-free mass (right)	0.7	3.7	10.0	0.9	-1.4	-1.5	-3.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	0.9	0.7	1.3	0.7
Emphysema/chronic bronchitis	0.7	0.8	1.1	-0.2	-1.0	-1.0	-1.0
Whole body fat mass	0.7	3.0	8.6	2.9	-0.8	1.1	-1.3
Asthma (self-reported)	0.7	1.3	3.2	1.1	0.8	1.8	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.4	-1.2	1.6	0.0	1.3
Mother’s age at death	0.7	0.9	2.6	-0.3	1.6	0.1	1.0
Arm fat-free mass (left)	0.7	3.7	10.0	1.0	-1.4	-1.3	-3.2
Risk taking	0.7	1.1	1.9	1.1	1.0	1.4	0.3
Systolic Blood Pressure	0.6	3.2	8.4	1.1	-1.7	-0.5	-2.9
Number of treatments/medications taken	0.6	1.0	1.7	1.3	-1.0	0.6	-0.9
Supplements: Zinc	0.6	0.6	1.5	-1.2	-0.4	-0.9	-0.1
Had other major operations	0.6	0.7	1.7	0.8	-0.0	1.3	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.8	1.7	1.1	0.5	1.3
Fluid intelligence score	0.6	1.2	1.3	-1.0	-1.2	-1.1	-1.0
Hip circumference	0.6	2.7	7.1	2.7	0.8	1.8	0.1
Worrier / anxious feelings	0.6	1.1	2.8	0.4	-0.6	-1.1	-1.7
Medication: Cholesterol lowering	0.6	0.9	1.4	1.2	0.1	1.0	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.8	-2.0	0.4	-1.9	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	1.1	-0.7	0.1	-1.4
Birth weight of first child	0.6	1.0	2.8	-0.4	-1.7	-0.5	-0.9
Medication: Amlodipine	0.6	0.8	1.7	-1.3	-1.2	-0.2	-0.2
Number of full brothers	0.6	0.7	1.3	-1.1	-0.3	-1.2	-0.6
Neck or shoulder pain in last month	0.6	0.9	2.4	1.6	1.0	0.3	-0.2
Pulse rate, automated reading	0.6	1.9	5.5	-2.3	0.7	-1.2	0.5
Leg pain on walking	0.6	0.7	1.2	0.8	-1.1	-0.2	-1.0
Leg fat-free mass (right)	0.6	3.3	9.6	3.1	0.1	1.2	-1.5
Illnesses of father: None of the above (group 1)	0.6	0.8	1.3	-0.8	-0.7	-1.1	-0.7
Leg predicted mass (right)	0.6	3.3	9.6	3.1	0.1	1.2	-1.5
Ever taken oral contraceptive pill	0.6	0.7	1.4	-1.2	-0.7	-0.6	-0.8
Hearing aid user	0.6	0.7	1.8	0.7	-1.3	-0.2	-0.8
Average weekly beer plus cider intake	0.6	0.9	2.8	-1.7	0.3	-0.6	0.4
Unable to work because of sickness or disability	0.6	0.7	1.8	1.4	-0.2	1.0	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.7	0.4	0.6	0.8	1.3
Arm predicted mass (left)	0.6	3.0	8.4	1.0	-1.1	-1.2	-2.9
Reaction Time	0.5	0.9	1.8	0.6	-1.1	-0.3	-1.4
Triglycerides	0.5	0.8	1.1	0.4	0.9	1.0	1.1
BMI	0.5	2.8	8.8	3.0	-0.3	1.4	-0.2
Hair Pigment	0.5	14.6	23.0	1.8	4.5	3.4	4.8
Leg fat-free mass (left)	0.5	2.5	7.6	2.8	0.1	1.0	-1.1
Serious illness, injury or assault to yourself	0.5	0.6	1.3	-0.1	-0.3	-1.1	-1.1
Multivitamins +/- minerals	0.5	0.6	1.9	0.4	-0.0	-0.5	-1.4
Leg predicted mass (left)	0.5	2.4	7.5	2.7	0.1	1.0	-1.1
Had menopause	0.5	0.7	1.3	-0.7	-0.5	-1.1	-0.8
Medication: Ramipril	0.5	0.7	2.3	0.3	-1.5	0.3	-0.6
Weight	0.5	2.6	5.2	2.3	-1.0	0.2	-2.0
Illnesses of mother	0.5	0.7	1.1	-1.0	0.8	-0.9	0.2
Breastfed as a baby	0.5	0.6	1.4	-0.1	1.2	-0.3	1.0
Blood clot in the leg (DVT)	0.5	0.6	1.3	0.5	0.5	0.9	1.2
Gout (self-reported)	0.5	0.7	2.4	-0.4	-1.5	-0.4	-0.1
Forced vital capacity (FVC), Best measure	0.5	1.9	3.9	-2.0	0.0	-1.8	-0.5
Medication: Seretide 50 evohaler	0.5	0.5	1.1	-1.1	0.5	0.1	0.8
Heart disease (mother)	0.5	0.6	1.0	0.7	-1.0	0.2	-1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	-0.4	-0.4	0.8	1.1
Fractured/broken bones in last 5 years	0.5	0.6	0.8	-0.7	-0.9	-0.7	-0.9
Leg fat mass (left)	0.5	2.1	6.0	2.4	-0.7	0.6	-1.3
Diabetes (father)	0.4	0.4	0.8	0.7	-0.1	-0.9	-0.7
Diabetes (mother)	0.4	0.6	1.0	-0.8	-1.0	-0.7	-0.4
Number of incorrect matches in round	0.4	0.6	1.7	-0.5	-0.6	-0.5	-1.3
Hair/balding pattern: Pattern 2	0.4	0.6	1.1	-0.2	-1.0	-0.4	-1.0
Forced vital capacity (FVC)	0.4	1.7	4.2	-2.0	0.8	-1.3	0.3
Pain all over the body in last month	0.4	0.5	0.7	-0.7	-0.7	-0.6	-0.8
Trunk fat-free mass	0.4	2.4	7.1	0.6	-0.9	-1.2	-2.7
Trunk predicted mass	0.4	2.4	7.2	0.5	-0.9	-1.2	-2.7
Loud music exposure frequency	0.4	0.5	1.5	1.2	-0.4	0.4	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	-0.2	0.4	-1.2	-0.8
Age at first live birth	0.4	0.7	2.1	-1.5	-0.4	-0.8	0.1
Leg fat mass (right)	0.4	1.5	4.7	2.2	-0.5	0.6	-0.9
Alcohol intake frequency.	0.4	1.0	1.8	1.3	-0.6	0.5	-1.3
Knee pain experienced in last month	0.4	0.6	1.4	1.2	-0.6	0.3	-0.7
Illnesses of father: Heart disease	0.4	0.5	1.1	0.6	-0.7	0.4	-1.0
Whole body water mass	0.4	2.2	5.6	1.6	-0.6	-0.4	-2.4
Medication: Blood pressure	0.4	0.7	1.7	-1.3	-1.0	-0.3	0.4
Basal metabolic rate	0.4	2.1	4.7	1.8	-0.6	-0.2	-2.2
Alcohol drinker status: Previous	0.4	0.4	0.9	0.9	0.2	0.9	0.2
Alzheimer’s Disease (in mother)	0.3	0.3	1.0	-0.1	-1.0	0.1	-0.5
Ovarian Cancer	0.3	0.4	1.0	-1.0	-0.2	-0.6	0.0
HbA1C	0.3	0.4	1.3	0.2	-1.1	-0.1	-0.4
Blood Platelet Count	0.3	3.7	6.0	1.4	1.2	2.4	2.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	0.1	0.7	0.6	0.8
Vitamin and mineral supplements	0.3	0.3	1.1	0.1	0.2	0.4	1.1
Medication: Metformin	0.3	0.4	1.0	0.9	0.3	1.0	0.1
Average weekly fortified wine intake	0.3	0.3	0.8	-0.9	0.4	0.2	0.5
Relative age voice broke	0.3	0.5	1.2	-0.3	0.9	0.3	1.1
High blood pressure (mother)	0.3	0.4	1.3	1.1	0.1	0.3	-0.3
Mouth/teeth dental problems	0.3	0.5	1.0	-0.6	1.0	0.6	0.4
Impedance of arm (right)	0.3	1.6	3.8	-1.1	0.8	0.9	2.0
Prospective memory result	0.3	0.4	0.7	0.5	0.4	0.8	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.0	0.4	-0.5	-0.1	-1.0
Worry too long after embarrassment	0.3	0.5	1.0	0.1	-0.5	-0.8	-1.0
Wheeze or whistling in the chest in last year	0.3	0.6	1.0	0.8	-0.7	0.6	-1.0
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.6	0.8	-0.3	0.5
Medication: Allopurinol	0.3	0.4	1.5	0.4	-1.2	0.4	0.2
Whole body fat-free mass	0.3	2.0	5.0	1.6	-0.4	-0.3	-2.2
Average weekly red wine intake	0.3	0.4	1.1	0.7	-1.0	0.3	-0.2
Ever had bowel cancer screening	0.3	0.3	0.8	-0.5	-0.1	-0.9	-0.5
Diabetes diagnosed by doctor	0.3	0.5	0.8	0.7	0.4	0.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.1	-0.6	-0.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.8	0.0	-0.9	-0.6	-0.6
Mineral and other dietary supplements	0.3	0.4	0.7	0.3	0.1	0.9	0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.8	-0.7	0.3	-0.1
High cholesterol (Self-reported)	0.3	0.5	1.3	0.2	0.4	0.5	1.1
Leg fat percentage (left)	0.3	1.0	2.3	1.5	-0.9	0.3	-0.9
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.3	-1.1	0.4	-1.1	-0.8
Supplements: Calcium	0.3	0.3	0.6	-0.7	0.7	-0.3	0.4
Irritable Bowel Disease (IBD)	0.2	0.5	1.4	-0.5	-1.2	0.4	0.2
Major Depression (MDD)	0.2	0.2	0.7	0.0	0.3	0.0	-0.8
Prostate Cancer	0.2	0.3	0.5	-0.4	0.5	-0.7	0.5
Age at First Birth	0.2	0.3	0.5	0.7	0.1	0.7	0.3
Sensitivity / hurt feelings	0.2	0.3	0.5	0.2	-0.6	-0.7	-0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.7	-0.4	-0.3	-0.4	0.9
Medication for hormone replacement therapy	0.2	0.2	0.4	0.4	-0.5	0.6	-0.0
Medication: Co-codamol	0.2	0.2	0.8	-0.1	-0.9	0.0	-0.3
Severe depression (siblings)	0.2	0.2	0.5	-0.4	0.1	0.4	0.7
High blood pressure	0.2	0.5	0.9	0.6	-0.2	0.9	0.9
Diabetes (self-reported)	0.2	0.4	0.7	0.6	0.3	0.5	0.9
Impedance of arm (left)	0.2	1.1	2.7	-1.6	0.1	0.0	1.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	0.3	0.5	0.7	-0.4
Shortness of breath walking on level ground	0.2	0.3	1.0	1.0	-0.2	0.1	0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.9	0.5	-0.3	0.5
Number of full sisters	0.2	0.2	0.4	-0.0	-0.2	-0.7	-0.5
Supplements: Vitamin C	0.2	0.2	0.4	-0.5	-0.6	0.2	-0.6
Hypertension (Self-reported)	0.2	0.7	1.2	0.7	-0.4	1.1	0.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	0.8	0.2	0.1	-0.6
Medication for cholesterol	0.2	0.2	0.4	0.3	0.5	-0.4	-0.6
Back pain experienced in last month	0.2	0.3	0.8	-0.3	-0.3	-0.3	-0.9
Osteoarthritis (self-reported)	0.2	0.2	0.7	0.2	-0.8	0.0	-0.4
Medication: Gliclazide	0.2	0.2	0.6	0.8	-0.0	0.3	-0.5
Guilty feelings	0.2	0.3	0.8	0.9	-0.6	-0.3	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	-0.3	-0.2	-0.6	-0.8
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.5	0.3	0.5	0.7
Medication: Lisinopril	0.2	0.2	0.7	-0.2	-0.9	0.4	-0.1
Alcohol drinker status: Never	0.2	0.3	0.7	0.3	-0.4	0.4	-0.8
Diastolic blood pressure, automated reading	0.2	0.7	1.5	0.5	0.4	1.0	1.2
Commuting to job workplace: Cycle	0.2	0.2	0.5	-0.5	-0.7	-0.2	-0.3
Pain experienced in last month	0.2	0.3	0.9	-0.4	0.2	0.4	1.0
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	0.3	0.3	0.8	0.4
Blood Eosinophil Count	0.1	1.1	2.3	0.9	1.5	1.0	0.6
Cardiovascular Disease	0.1	0.4	1.0	0.3	-0.2	0.8	1.0
Hypothyroidism (self reported)	0.1	0.2	0.4	-0.6	0.3	-0.7	-0.2
Tanning	0.1	0.6	1.2	0.4	-0.8	-0.7	-1.1
Hand grip strength (left)	0.1	0.4	0.8	-0.5	0.9	-0.5	0.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	-0.0	-0.1	-0.5	-0.6
Hand grip strength (right)	0.1	0.2	0.5	-0.2	0.7	-0.4	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.5	0.2	-0.3	-0.2
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	-0.0	-0.0	-0.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	0.4	-0.4	-0.1	-0.5
Medication: Simvastatin	0.1	0.2	0.4	-0.2	-0.6	0.0	0.4
Time employed in main current job	0.1	0.1	0.4	-0.7	-0.2	-0.1	-0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.7	0.4	-0.2	0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	0.4	0.4	0.5	0.5
Tense / ‘highly strung’	0.1	0.2	0.3	0.0	0.6	0.3	0.6
Hair/balding pattern: Pattern 4	0.1	0.3	1.1	0.4	-1.0	0.1	0.1
Headache pain in last month	0.1	0.2	0.4	0.6	0.6	-0.3	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.5	0.4	-0.6	-0.1
Leg fat percentage (right)	0.1	0.5	1.4	1.2	-0.6	0.4	-0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.3	-0.7	0.2	-0.2
Financial situation satisfaction	0.1	0.1	0.4	0.7	0.2	-0.3	0.0
Eye problems/disorders: Glaucoma	0.1	0.1	0.1	-0.0	0.3	0.3	0.4
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	-0.5	-0.5	-0.3	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.4	0.6	0.0	0.1	-0.2
Irritability	0.1	0.2	0.5	0.7	-0.2	0.5	-0.0
Ever depressed for a whole week	0.1	0.1	0.4	-0.6	-0.1	-0.0	0.2
Myopia	0.1	0.1	0.3	0.5	0.4	0.0	-0.1
Pack years of smoking	0.1	0.1	0.4	0.1	-0.0	0.6	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Pack years adult smoking proportion	0.0	0.1	0.1	-0.1	-0.2	0.4	0.3
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.2	0.1	-0.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.1	0.1	0.1	-0.3	0.4	-0.1
Loneliness, isolation	0.0	0.0	0.0	0.0	0.1	-0.2	0.0

Hub : Genes

ISYNA1

Models

Trait associations