Hub : Genes

ARRDC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.3363	0.0849	6.3e-05	0.005	NA	-0.004	NA	0.000	0.17000	NA	5.7e-01	NA	3.2e-01
2	GTEx	Thyroid	0.1360	0.0480	4.6e-03	0.011	NA	0.014	NA	0.007	0.04200	NA	2.7e-02	NA	8.5e-02
3	TCGA	Bladder Urothelial Carcinoma	0.0480	0.0250	7.2e-03	0.016	0.022	0.013	NA	0.021	0.01500	5.0e-03	2.7e-02	NA	5.9e-03
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0817	0.0306	8.2e-05	0.033	0.043	0.047	NA	0.054	0.00011	1.3e-05	4.7e-06	NA	9.3e-07
5	TCGA	Lung Adenocarcinoma	0.0391	0.0217	5.7e-03	0.008	0.012	0.025	NA	0.015	0.03400	1.4e-02	5.4e-04	NA	6.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	1.9	1.4	0.0	-0.5	-1.2	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	0.5	0.9	-0.6	0.8	1.3
Depressed Affect (Nagel 2018)	0.3	0.6	2.2	-1.5	-0.3	0.7	0.2	0.0
Depression (Nagel 2018)	0.4	0.6	2.0	-1.4	0.0	0.5	0.6	0.8
Intelligence (Savage-Jansen 2018)	1.2	3.7	9.7	-0.2	2.8	-0.6	-3.1	0.4
Neuroticism (Nagel 2018)	0.6	1.3	5.7	-2.4	0.7	0.5	-0.5	-0.2
Schizophrenia (2018)	1.1	2.2	3.8	-0.5	1.8	-0.4	1.9	1.9
Schizophrenia vs Biploar Disorder	0.9	1.2	5.3	-2.3	0.0	-0.8	0.2	-0.3
Worry (Nagel 2018)	1.3	2.7	9.6	-3.1	1.3	-0.4	-0.9	-1.2
Alzheimer’s Disease (in mother)	1.0	1.2	3.9	1.4	0.1	-2.0	0.3	-0.0
Alzheimer’s Disease (in father)	0.5	0.5	1.2	-0.9	0.7	0.2	0.0	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.9	0.3	-1.0	0.4	0.2
Crohns Disease (2017)	1.1	2.5	5.0	-1.0	-2.2	-1.0	0.6	-2.2
Irritable Bowel Disease (IBD)	0.3	0.8	3.5	-0.0	0.5	0.3	-0.0	-1.9
Ulcerative Colitis (UC)	1.5	2.8	10.4	0.2	3.2	1.9	-0.1	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	2.7	5.2	10.1	-3.2	2.4	-1.1	-2.6	-1.4
Verbal and Numeric Reasoning (VNR)	0.8	1.8	5.5	1.0	1.3	-0.9	-2.3	0.2
Breast Cancer	0.4	0.9	4.2	2.1	0.3	-0.0	-0.4	0.1
Ovarian Cancer	1.2	1.5	7.3	-2.7	0.2	0.2	-0.2	0.6
Prostate Cancer	1.8	2.5	4.9	1.3	0.3	2.0	2.2	1.2
Age at First Birth	0.7	1.1	3.0	1.5	0.2	0.2	-1.7	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	2.1	-1.4	-1.0	-0.2	0.5	-1.4
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.5	0.8	2.2	0.3	-1.5	-0.0	-0.7	-1.1
Mean Putamen Volume	2.0	2.3	4.4	1.0	1.3	0.6	2.1	2.0
Fasting Glucose	0.3	0.3	0.9	0.6	-1.0	0.3	0.5	0.2
HbA1C	1.1	1.3	2.6	-1.0	1.2	-1.0	-1.6	-0.2
HDL Cholesterol	0.8	1.3	2.6	-0.4	1.6	1.4	0.6	1.3
LDL Cholesterol	0.8	1.3	4.8	0.4	-0.5	-2.2	-0.1	-1.1
Lupus	1.1	1.7	4.1	-1.9	-0.4	-0.5	-0.7	-2.0
Neuroticism (2016)	0.9	1.3	2.9	-1.1	-0.9	-0.4	-1.1	-1.7
Primary Biliary Cirrhosis	1.3	1.9	5.9	-1.6	-2.4	-0.2	0.4	-0.8
Rheumatoid Arthritis	1.2	1.6	2.4	-1.6	-0.8	1.0	1.4	1.3
Schizophrenia (2014)	0.3	0.7	1.3	-0.8	0.0	-0.6	1.1	1.1
Triglycerides	1.9	3.1	6.5	1.6	-2.1	-0.4	-1.4	-2.5
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.6	0.8	3.2	0.5	0.0	1.8	-0.5	-0.6
Blood Eosinophil Count	0.8	5.9	13.1	-3.6	2.6	-1.8	-2.0	-1.7
Blood Platelet Count	0.5	5.7	7.7	2.8	2.8	2.7	1.0	2.2
Blood Red Count	0.5	5.2	9.1	-2.9	3.0	2.4	1.4	1.1
Blood White Count	0.3	1.9	5.1	-1.3	-0.1	1.5	-0.4	-2.3
Heel T-Score	5.3	41.9	93.9	1.5	-7.7	-5.6	-4.7	-9.7
BMI	1.3	7.7	17.7	-4.2	-0.8	2.9	3.3	0.8
Height	0.9	17.2	35.3	-1.3	-2.2	-5.9	-4.9	-4.5
Waist Hip Ratio (WHR)	2.5	11.4	27.5	-0.9	-1.1	2.2	4.8	5.2
Systolic Blood Pressure	0.6	2.9	5.8	-2.4	1.1	1.6	2.2	0.5
Smoking Status	0.3	0.7	2.4	-1.5	0.3	-0.9	-0.5	0.5
Allergy or Eczema	1.2	3.2	6.3	-0.5	1.7	2.2	1.2	2.5
Cardiovascular Disease	0.5	1.6	5.2	-1.0	-0.7	0.6	2.3	-1.0
Hypothyroidism (self reported)	0.1	0.3	0.5	-0.2	0.7	0.7	-0.7	-0.3
Respiratory disease	1.0	2.3	4.8	-0.6	1.2	2.2	1.6	1.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.8	0.5	0.6	-0.1	-0.2	-0.9
Lung FEV1/FVC ratio	0.4	2.1	4.1	0.3	2.0	0.6	2.0	1.4
Lung FVC	0.3	1.4	2.0	1.4	0.5	-1.3	-1.4	-1.0
Neuroticism	0.4	1.1	3.3	-1.8	0.1	-0.8	0.4	-1.1
Chronotype (morning person)	3.1	7.1	29.8	-5.5	-0.2	-0.6	-1.2	-2.0
Hair Pigment	0.1	4.1	13.1	0.2	1.9	1.3	1.3	3.6
Tanning	0.1	1.4	5.2	0.6	-0.9	0.4	-0.8	-2.3
Hand grip strength (left)	0.6	1.6	5.1	1.3	-0.2	-2.3	-0.6	-0.7
Number of treatments/medications taken	0.6	1.0	3.2	-1.8	0.6	0.3	0.0	-1.2
Average weekly spirits intake	1.4	1.7	5.7	0.2	-0.9	0.7	2.4	1.3
Sensitivity / hurt feelings	1.4	2.4	6.5	-0.2	0.5	-1.0	-2.5	-2.1
Frequency of depressed mood in last 2 weeks	0.9	1.3	4.2	-2.1	1.1	-0.0	-1.0	0.0
Hearing difficulty/problems: Yes	0.7	1.1	2.5	-0.8	0.9	0.7	1.6	1.0
Relative age of first facial hair	0.3	0.6	1.6	0.1	1.1	-0.6	-0.1	-1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.9	0.1	-1.1	0.0	0.1	-1.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	-0.8	1.1	-0.3	1.3	0.7
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	0.4	-0.0	1.0	0.4	1.0
Systolic blood pressure, automated reading	0.7	1.9	5.3	-1.4	0.5	0.8	2.3	1.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.4	0.1	0.6	-0.2	-1.5	-0.7
Angina	0.5	0.7	2.4	0.3	-1.5	-0.2	0.7	0.5
Medication for hormone replacement therapy	0.4	0.4	1.0	0.4	1.0	-0.8	-0.6	0.2
Vitamin and mineral supplements	0.4	0.6	1.3	-0.2	0.2	-0.4	1.1	1.1
Supplements: Zinc	0.8	0.9	3.0	-0.5	-0.0	1.7	0.4	1.0
Medication: Co-codamol	0.8	0.9	2.3	0.3	0.9	0.4	-1.1	-1.5
Medication: Metformin	0.7	1.0	2.9	-1.1	0.8	1.7	0.2	0.0
Diabetes (father)	0.8	1.0	2.1	0.7	0.5	1.4	1.4	0.5
Diabetes (mother)	0.7	0.8	3.5	-0.5	0.0	1.9	0.7	0.3
Severe depression (siblings)	2.1	2.4	5.4	0.1	-0.7	-0.9	-2.2	-2.3
Pack years adult smoking proportion	0.4	0.7	1.9	-1.4	-0.9	0.1	0.7	-0.1
Impedance of leg (right)	0.8	4.1	11.7	0.5	1.6	0.4	2.4	3.4
Leg fat-free mass (left)	0.6	3.1	5.3	-2.3	-1.7	-1.2	-1.5	-1.9
Trunk fat percentage	1.9	7.5	13.0	-2.9	-1.2	2.6	3.6	2.8
Hand grip strength (right)	0.5	1.4	2.7	1.3	0.1	-1.6	-1.5	-0.4
Townsend deprivation index at recruitment	0.8	1.1	3.3	-1.8	-0.6	0.3	-0.7	-1.1
Current tobacco smoking	0.5	0.9	3.3	-1.8	0.6	-0.4	0.1	0.7
Average weekly fortified wine intake	1.4	1.6	2.4	1.1	-1.5	1.4	1.6	0.4
Maternal smoking around birth	0.8	1.1	4.9	-2.2	0.0	-0.8	-0.5	0.3
Fed-up feelings	1.5	2.7	10.2	-3.2	0.0	1.3	-0.6	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	4.4	-2.1	0.4	0.5	-0.1	0.4
Relative age voice broke	0.5	0.8	2.5	-1.6	-0.4	-0.5	0.2	-1.0
Taking other prescription medications	0.6	0.9	3.5	-1.9	-0.5	0.2	-0.6	-0.8
Age when periods started (menarche)	0.1	0.1	0.4	0.1	0.3	0.2	-0.6	-0.2
Bilateral oophorectomy (both ovaries removed)	4.6	5.3	12.5	-0.2	-0.2	2.7	2.6	3.5
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	8.9	0.4	-3.0	-2.2	-0.6	-1.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.2	-0.5	-0.5	-0.8	-0.6	-1.1
Qualifications: CSEs or equivalent	0.2	0.3	1.3	-0.4	-0.0	1.1	0.1	-0.2
Serious illness, injury or assault to yourself	0.3	0.4	1.2	-0.6	-1.1	-0.5	0.5	0.0
High blood pressure	0.6	1.6	6.0	-0.7	-0.0	1.3	2.4	0.2
Hayfever, allergic rhinitis or eczema	1.0	2.3	4.8	-0.8	1.6	1.8	0.5	2.2
Multivitamins +/- minerals	0.2	0.2	0.5	0.2	-0.4	0.5	-0.1	-0.7
Stomach or abdominal pain in last month	1.4	1.8	6.6	-2.6	-0.6	-0.6	-0.7	-0.9
Supplements: Glucosamine	0.5	0.7	2.1	-0.0	1.4	0.3	0.1	1.2
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	3.3	-1.8	-0.9	-0.3	-0.3	-1.0
Medication: Atenolol	0.7	0.9	2.5	-1.6	-0.7	0.4	0.9	-0.6
Medication: Levothyroxine sodium	0.9	1.6	4.3	-0.6	-0.1	0.6	-1.7	-2.1
Sitting height	0.5	3.3	8.7	-0.8	-1.6	-3.0	-0.4	-2.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	-0.8	-0.7	0.0	0.5	-0.4
High blood pressure (mother)	1.7	2.3	6.4	-0.4	0.5	2.5	1.9	1.2
Body mass index (BMI)	1.0	4.2	8.1	-2.8	-1.5	1.9	2.5	0.8
Impedance of leg (left)	0.6	2.7	8.1	0.2	1.8	0.4	1.4	2.9
Leg predicted mass (left)	0.6	3.2	5.4	-2.3	-1.7	-1.3	-1.5	-1.9
Trunk fat mass	1.2	5.1	9.2	-3.0	-1.5	1.7	2.8	1.8
Waist circumference	1.5	5.5	9.8	-3.0	-1.1	1.8	3.1	2.1
Number of incorrect matches in round	1.0	1.7	6.2	-1.0	2.5	-1.1	-0.1	-0.3
Past tobacco smoking	0.5	1.0	2.0	0.2	-1.4	1.3	1.1	-0.2
Alcohol usually taken with meals	0.3	0.4	1.3	0.6	-0.5	0.5	0.2	-1.2
Nervous feelings	1.8	3.3	8.5	-2.9	1.1	-1.2	-1.1	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	10.3	-3.2	1.3	-0.7	-1.1	-0.6
Hearing difficulty/problems with background noise	1.1	1.8	4.6	-1.6	-0.9	0.9	-0.6	-2.1
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	0.1	0.7	0.8	-0.0	0.7
Had menopause	1.3	1.6	6.0	-0.1	-0.5	0.4	2.5	1.2
Had other major operations	1.6	1.9	3.3	0.5	1.7	1.8	1.4	1.1
Forced vital capacity (FVC)	0.8	2.9	7.9	0.6	0.3	-1.8	-2.8	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	5.2	0.7	-2.3	-1.9	-0.2	-1.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.8	0.9	-0.0	0.9	0.4	-0.9
Qualifications: None of the above	0.3	0.7	2.5	-0.4	-0.3	-1.6	0.8	0.6
Financial difficulties in last 2 years	0.6	0.7	2.2	1.0	-0.0	-1.5	-0.1	-0.8
Mouth/teeth dental problems	2.4	3.6	11.5	-0.6	2.3	1.0	-0.1	3.4
Heart attack	1.4	1.8	3.8	-0.7	-1.9	-1.1	-0.2	-2.0
Allergy	2.0	4.5	10.8	1.5	-2.1	-1.8	-1.3	-3.3
Pain all over the body in last month	1.4	1.5	4.6	-2.1	0.7	-0.9	-1.2	0.5
Diabetes (self-reported)	0.5	0.7	1.9	1.4	1.2	0.3	0.1	-0.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.3	-1.7	0.7	0.7	1.2	1.8
Medication: Ramipril	0.9	1.1	2.1	-0.9	-1.2	1.4	1.0	-0.6
Medication: Simvastatin	1.4	2.1	3.0	-1.2	-1.7	-1.4	1.6	1.0
Fluid intelligence score	0.7	1.4	5.1	-0.9	-0.6	-0.8	-2.3	-0.3
Illnesses of siblings	0.4	0.6	2.1	0.5	0.2	0.5	0.4	1.4
Neuroticism score	1.2	2.5	5.7	-2.4	0.4	-0.5	-1.3	-2.1
Weight	0.5	2.5	9.0	-3.0	-1.6	-0.1	0.8	-0.3
Impedance of arm (right)	0.8	3.6	7.6	2.2	1.4	1.5	1.2	2.8
Arm fat percentage (right)	1.9	7.4	14.5	-2.3	-1.4	3.1	3.8	2.3
Trunk fat-free mass	1.2	6.8	10.9	-1.9	-2.0	-3.1	-2.4	-3.3
Hip circumference	0.4	1.7	5.0	-2.2	-1.2	0.9	0.9	-0.6
Time employed in main current job	2.3	2.6	7.1	2.7	-2.0	0.3	1.4	0.1
Alcohol intake versus 10 years previously	0.3	0.4	1.4	0.6	0.4	1.2	-0.0	-0.5
Father’s age at death	1.1	1.5	4.0	1.8	0.1	0.0	0.6	2.0
Worrier / anxious feelings	1.3	2.5	6.2	-2.5	0.9	-0.6	-1.9	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.6	-1.6	-0.6	0.1	-0.4	-1.0
Falls in the last year	1.2	1.6	4.1	0.7	2.0	1.4	0.0	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.1	-0.8	-0.9	-0.4	-0.7	-1.0
Number of live births	1.9	2.7	8.9	0.7	-1.8	-3.0	0.6	0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.9	0.8	0.5	-1.1	-2.2	-1.2
Pulse rate	1.8	3.1	6.8	1.3	0.4	2.6	1.8	1.9
Happiness	1.1	1.4	3.0	-0.3	-0.7	-1.0	-1.7	-1.5
Noisy workplace	0.4	0.4	1.0	-1.0	-0.2	0.4	-1.0	-0.2
Qualifications: A levels/AS levels or equivalent	2.0	4.3	10.5	-0.2	0.7	-2.4	-3.2	-2.3
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.2	-0.0	1.1	0.1	0.3	0.5
Mouth/teeth dental problems: Dentures	1.2	2.0	4.2	0.5	-2.0	-1.9	1.1	-0.9
Asthma	0.6	1.2	3.2	-0.9	1.0	0.9	0.5	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.8	-1.0	1.7	1.1	0.2	0.7
Medication: Cholesterol lowering	0.6	0.9	1.4	-1.2	-0.9	-1.1	-0.6	-0.8
Depression (self-reported)	0.4	0.4	1.4	-0.3	0.1	-0.6	-1.2	-0.6
Medication: Lansoprazole	0.8	0.9	3.2	-1.8	-0.0	0.2	1.0	0.1
Prospective memory result	0.1	0.1	0.4	0.1	0.2	-0.2	0.4	0.6
Lung cancer (father)	0.2	0.3	0.8	-0.9	0.1	0.2	-0.3	-0.6
Illnesses of mother	2.3	2.9	5.5	0.2	-1.1	-1.6	-2.3	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.8	3.4	0.5	0.3	-1.6	-1.9	-1.6
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	0.3	0.4	0.5	-0.1	-0.5
Impedance of arm (left)	0.7	3.3	7.7	1.5	1.3	2.0	0.9	2.8
Arm fat mass (right)	1.1	4.6	9.1	-3.0	-1.8	1.8	2.4	1.2
Trunk predicted mass	1.2	6.7	10.5	-1.9	-1.9	-3.1	-2.4	-3.2
Standing height	0.8	8.0	19.1	-0.8	-1.0	-4.4	-3.5	-2.6
Length of working week for main job	0.6	0.7	1.4	0.7	-0.1	1.1	0.6	-1.2
Exposure to tobacco smoke at home	1.2	1.4	4.9	2.2	0.3	-1.2	0.4	-0.6
Breastfed as a baby	1.7	2.1	6.3	2.5	-0.9	-1.8	0.1	0.4
Tense / ‘highly strung’	1.5	2.5	5.9	-2.4	0.6	-0.5	-1.6	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.6	-1.2	1.0	-0.2	-1.1	-0.5
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	-0.7	0.8	-0.7	-0.2	0.7
Birth weight of first child	0.6	1.1	4.8	-0.8	-0.0	-0.3	0.4	2.2
Peak expiratory flow (PEF)	0.5	1.1	1.8	1.3	1.1	1.2	-0.8	0.3
Pulse wave reflection index	0.1	0.2	0.6	-0.3	0.4	0.8	0.1	-0.1
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	-1.2	0.5	0.2	-0.8	0.9
Loud music exposure frequency	2.2	2.4	7.5	1.0	-0.8	-1.0	-1.4	-2.7
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.1	0.2	1.1	-1.1	-2.0	-2.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.6	1.9	-0.3	0.0	-1.5	-0.9
Blood clot in the leg (DVT)	0.5	0.6	1.6	-0.1	0.3	-1.0	0.5	1.3
Medication: Paracetamol	0.5	0.7	1.3	-1.0	-0.6	1.1	1.0	0.0
Headache pain in last month	1.0	1.7	4.6	-0.9	-1.3	-0.3	-1.0	-2.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	0.8	0.6	0.1	-0.5	0.1
Glaucoma (self-reported)	0.6	0.7	2.0	0.1	-0.1	1.4	1.0	0.7
Gout (self-reported)	1.1	1.5	3.6	-1.1	1.4	-0.8	0.2	1.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	-0.6	-0.2	0.5	-0.9	-1.2
Medication: Amlodipine	0.9	1.3	2.3	-1.5	1.0	1.5	1.0	-0.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.3	-1.5	-0.1	0.1	0.0	1.5
Birth weight	0.4	0.9	1.9	1.2	0.7	-0.2	0.9	1.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	-0.0	0.6	0.1	0.7	0.6
High blood pressure (siblings)	0.3	0.5	1.3	-1.1	-1.0	0.2	0.2	-0.4
Forced vital capacity (FVC), Best measure	0.7	2.7	5.3	-0.2	0.3	-2.3	-2.3	-1.7
Body fat percentage	2.4	9.3	17.0	-3.0	-1.0	3.0	4.1	3.2
Leg fat percentage (right)	2.5	9.0	20.7	-2.6	-0.8	2.5	4.6	3.2
Arm fat-free mass (right)	1.1	5.8	10.2	-3.2	-1.7	-2.4	-1.9	-2.5
Exposure to tobacco smoke outside home	1.1	1.4	4.9	-1.0	0.8	0.1	2.2	0.7
Comparative body size at age 10	0.4	1.1	1.6	-0.6	1.3	1.2	0.9	1.1
Number of full brothers	1.3	1.7	2.8	-0.9	-1.4	-1.1	-1.3	-1.7
Worry too long after embarrassment	2.3	3.9	9.0	-2.2	0.6	-1.1	-3.0	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.6	-1.2	-1.2	0.3	0.4	0.5
Wheeze or whistling in the chest in last year	1.5	2.6	4.9	-1.4	0.7	2.2	1.1	2.1
Number of children fathered	1.1	1.2	4.1	0.8	-2.0	0.3	0.6	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	3.0	-1.7	-0.4	-0.2	1.2	-0.1
Age at first live birth	0.9	1.7	4.2	1.3	0.6	1.0	-2.0	-1.1
Pulse wave peak to peak time	0.2	0.2	0.6	-0.3	-0.3	-0.8	-0.3	0.1
Health satisfaction	0.8	1.1	3.8	-1.9	-0.1	0.7	-1.0	-0.4
Shortness of breath walking on level ground	1.3	1.6	3.1	-1.6	-0.5	1.8	0.9	1.1
Qualifications: College or University degree	1.7	5.3	11.8	0.7	0.1	-2.3	-3.0	-3.4
Eye problems/disorders: None of the above	1.1	1.3	5.1	-0.5	-0.3	-2.3	-0.7	-0.7
Mouth/teeth dental problems: Loose teeth	1.5	1.8	6.4	0.1	-0.4	2.5	0.6	-1.4
Emphysema/chronic bronchitis	0.7	0.8	3.6	0.3	-0.3	1.9	0.4	0.3
Medication for pain relief, constipation, heartburn	0.6	1.0	2.1	1.5	0.3	-1.2	-1.1	-0.3
Neck or shoulder pain in last month	1.4	2.0	5.2	1.7	-0.1	-0.7	-1.2	-2.3
Medication: Blood pressure	0.4	0.6	1.6	-0.6	-0.0	1.1	1.2	0.1
Angina (self-reported)	0.4	0.6	2.5	0.2	-1.6	0.2	0.5	0.3
Migraine (self-reported)	0.9	1.1	2.4	0.1	1.4	1.6	0.7	0.8
Medication: Ibuprofen	1.3	1.6	5.0	-2.2	1.4	0.6	-0.1	0.6
Medication: Allopurinol	0.8	1.0	2.8	-1.5	-0.2	-0.4	-0.0	1.7
Medication: Omeprazole	1.9	2.3	5.5	-2.4	-1.3	1.6	1.1	-0.7
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.4	0.5	0.3	-0.3	-0.4
Mean time to correctly identify matches	2.3	4.4	7.8	-2.8	1.5	-2.5	-2.0	-1.3
Heart disease (mother)	1.3	1.6	5.3	-2.3	-1.4	0.3	0.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	2.4	1.6	0.8	0.9	1.4	1.1
Whole body fat mass	1.3	5.5	10.5	-3.2	-1.4	1.7	2.9	2.0
Leg fat mass (right)	1.3	5.0	9.5	-3.1	-1.4	1.4	2.9	1.7
Arm predicted mass (right)	1.2	6.2	10.4	-3.2	-1.8	-2.6	-2.1	-2.6
Pulse rate, automated reading	0.4	1.2	5.1	2.3	-0.5	-0.0	0.6	0.7
Alcohol intake frequency.	0.7	1.6	4.3	-2.1	-1.0	0.2	-1.3	-1.0
Comparative height size at age 10	0.5	2.7	8.8	-1.1	-0.4	-3.0	-1.7	-0.1
Number of full sisters	1.7	2.0	3.8	-1.9	-1.4	-0.9	-1.8	-0.8
Suffer from ‘nerves’	1.0	1.6	3.0	-1.7	1.3	-0.9	-0.4	-1.5
Overall health rating	0.3	0.6	2.4	-1.6	-0.2	0.0	-0.1	-0.7
Chest pain or discomfort	1.7	2.4	10.2	-3.2	-1.1	0.7	-0.2	0.1
Had major operations	2.8	3.3	10.5	-0.3	-3.2	-1.2	-1.4	-1.7
Age at last live birth	0.5	0.7	1.0	1.0	0.7	-0.7	-0.9	-0.8
Family relationship satisfaction	1.7	2.1	4.7	-0.5	-0.1	-1.2	-2.2	-2.1
Leg pain on walking	1.2	1.5	5.2	-0.4	2.3	1.4	-0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	4.3	5.2	10.5	-0.2	2.0	3.2	2.0	2.8
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.0	2.0	-0.9	-1.2	0.9	-1.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	0.5	-0.1	1.3	-0.5	1.0
Medication: Aspirin	0.3	0.4	1.4	1.2	0.2	0.1	0.6	-0.1
Supplements: Vitamin C	0.6	0.7	2.7	1.6	-0.3	-0.3	0.0	-0.8
Knee pain experienced in last month	0.3	0.4	1.2	-0.2	0.4	1.1	0.6	0.5
Hypertension (Self-reported)	0.6	1.7	5.7	-0.9	-0.1	1.4	2.4	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	8.0	-2.8	1.0	1.1	0.3	0.6
Illnesses of father: Heart disease	0.3	0.4	0.9	-0.4	-0.5	0.4	1.0	-0.6
Illnesses of siblings: Diabetes	1.0	1.2	3.1	1.8	-0.7	-0.2	-0.3	-1.5
Smoking status: Previous	0.6	0.9	1.9	1.0	1.4	-0.9	-1.0	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.0	-0.8	-0.2	-1.4	-2.0	-1.5
Whole body fat-free mass	1.0	5.8	8.2	-2.3	-1.9	-2.6	-2.3	-2.9
Leg fat-free mass (right)	0.8	4.3	5.8	-2.4	-1.8	-1.5	-2.1	-2.4
Arm fat percentage (left)	1.9	7.8	13.2	-2.5	-1.6	3.5	3.6	2.3
Average weekly red wine intake	0.2	0.2	0.6	0.6	-0.3	-0.1	-0.4	-0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-0.9	-0.4	-1.0	-0.5	-0.5
Mood swings	0.8	1.5	3.6	-1.4	-0.2	-0.1	-1.3	-1.9
Loneliness, isolation	0.8	1.1	3.3	-1.8	-0.7	0.3	-0.9	-0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.5	-0.3	-0.4	0.7	-0.3	-0.7
Ever had bowel cancer screening	0.4	0.4	1.0	0.2	-0.6	-0.8	-0.2	-1.0
Diabetes diagnosed by doctor	0.3	0.5	1.5	0.7	1.2	0.3	-0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	0.3	0.0	1.0	0.4	-0.9
Friendships satisfaction	1.6	2.0	5.0	-0.8	-0.4	-0.3	-2.0	-2.2
Qualifications: nursing, teaching	0.9	1.4	3.8	1.1	-0.5	-0.3	-1.9	-1.2
Commuting to job workplace: Walk	0.8	0.9	3.0	-1.0	-0.7	1.7	-0.3	-0.0
Eye problems/disorders: Cataract	0.5	0.6	1.5	-0.4	-0.9	0.6	1.2	0.3
Mouth/teeth dental problems: Mouth ulcers	3.7	5.8	20.7	-0.2	-2.9	-0.1	-0.3	-4.5
Medication for cholesterol	0.5	0.8	3.7	0.1	-0.2	0.4	-1.9	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	-0.7	0.7	-0.5	-0.6	-1.2
Back pain experienced in last month	0.4	0.6	1.4	-0.2	0.7	0.8	1.2	0.5
Mineral and other dietary supplements	0.4	0.6	1.7	-0.8	-1.3	0.5	0.4	0.0
Breast cancer (self-reported)	0.7	0.9	1.9	1.2	0.0	0.5	1.4	0.8
Asthma (self-reported)	0.6	1.2	3.1	-0.9	1.2	0.7	0.3	1.8
Osteoporosis (self-reported)	1.3	1.6	3.1	-1.0	-1.8	1.3	1.2	0.9
Osteoarthritis (self-reported)	2.6	3.4	6.5	-0.5	0.8	1.9	2.6	2.5
Medication: Aspirin	0.4	0.5	1.1	1.0	0.1	0.2	1.0	0.6
Medication: Gliclazide	1.1	1.2	4.8	-0.7	0.1	0.8	-0.2	-2.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.3	0.2	0.4	-0.4	-1.1	-0.9
Smoking status: Current	0.9	1.4	4.4	-2.1	0.8	-1.3	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.4	0.7	-0.4	-1.2	-0.0	0.3
Whole body water mass	1.0	5.8	8.8	-2.2	-2.0	-2.5	-2.3	-3.0
Leg predicted mass (right)	0.8	4.3	5.6	-2.4	-1.8	-1.6	-2.2	-2.3
Arm fat mass (left)	1.1	4.4	7.3	-2.7	-1.8	1.9	2.5	1.3
Number of self-reported non-cancer illnesses	0.6	1.1	3.0	-1.3	-0.8	1.7	-0.1	0.3
Average weekly champagne plus white wine intake	0.4	0.5	1.8	0.3	-1.4	0.2	-0.8	0.1
Miserableness	0.1	0.2	1.1	-0.1	0.1	-0.0	0.2	-1.1
Guilty feelings	0.8	1.1	4.5	-2.1	0.7	0.0	-0.6	0.5
Wears glasses or contact lenses	1.2	1.4	4.1	-0.7	0.1	0.5	1.4	2.0
Ever taken oral contraceptive pill	0.8	0.9	2.0	-0.2	0.4	-0.8	-1.4	-1.2
Hearing aid user	0.4	0.4	0.6	0.8	0.7	-0.8	-0.1	0.5
Mother’s age at death	0.4	0.5	1.2	1.0	-0.2	-1.1	0.2	-0.6
Financial situation satisfaction	0.9	1.1	3.2	-0.2	-1.8	0.1	-0.7	-1.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.4	0.3	-1.2	1.0	1.2	0.0
Commuting to job workplace: Public transport	0.3	0.4	1.0	-0.0	0.5	1.0	-0.2	0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	0.4	-0.6	0.5	0.6	-0.0
Medication: Blood pressure	0.7	1.3	4.3	0.6	-0.7	1.0	2.1	0.3
Pain type(s) experienced in last month: Hip pain	1.4	1.7	3.6	-1.2	0.2	1.7	0.8	1.9
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.1	1.8	0.8	-0.8	-0.6	-0.8
High cholesterol (Self-reported)	0.4	0.6	1.1	-0.9	-0.5	-1.0	1.0	-0.0
Medication: Bendroflumethiazide	0.9	1.4	4.5	-0.4	-0.2	1.5	2.1	0.3
Medication: Paracetamol	0.3	0.4	1.0	-0.8	-0.0	1.0	0.7	0.1
Medication: Lisinopril	0.1	0.1	0.3	-0.3	0.4	-0.3	-0.0	0.5
Medication: Atorvastatin	0.6	0.7	2.5	-0.3	0.3	-0.0	-0.9	-1.6
Illnesses of father: High blood pressure	1.4	1.8	4.4	-2.1	-0.2	1.6	0.9	1.0
Alcohol drinker status: Never	0.9	1.0	2.9	-1.7	-1.1	0.7	0.6	-0.3
Ever smoked	0.5	0.9	2.7	0.0	1.0	-0.9	-1.6	-0.1
Basal metabolic rate	0.9	4.8	6.8	-2.6	-2.0	-2.0	-1.7	-2.4
Leg fat percentage (left)	2.2	8.0	16.0	-2.9	-0.7	2.6	4.0	2.9
Arm fat-free mass (left)	1.0	5.2	8.0	-2.5	-1.8	-2.8	-1.7	-2.4
Number of operations (self-reported)	0.3	0.4	1.2	0.0	-0.7	-0.4	-1.1	-0.6
Average weekly beer plus cider intake	0.2	0.3	1.0	-0.3	0.5	-1.0	0.3	-0.5
Irritability	0.3	0.6	1.8	-0.4	1.3	0.9	0.1	0.2
Risk taking	2.1	3.0	5.0	-0.5	-1.8	-2.2	-1.3	-2.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	0.1	-0.2	-0.3	0.1	0.7
Fractured/broken bones in last 5 years	1.9	2.4	8.4	-0.2	2.9	0.8	0.2	1.7
Age started oral contraceptive pill	2.1	2.6	4.6	-2.2	-0.9	-1.8	-1.1	-1.8
Diastolic blood pressure, automated reading	0.7	2.1	6.1	-0.8	-1.3	1.5	2.5	0.1
Ever depressed for a whole week	0.2	0.2	0.6	-0.2	0.4	0.4	-0.7	-0.4
Unable to work because of sickness or disability	0.9	1.2	2.4	-1.5	0.7	-1.1	-1.3	-0.4
Commuting to job workplace: Cycle	0.8	1.0	2.2	0.7	1.5	0.9	-0.5	-1.0
Myopia	0.9	1.3	4.9	-1.0	0.5	0.2	-2.2	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	5.0	0.5	0.6	-1.0	-2.2	-0.0
Cholesterol lowering medication	0.6	0.9	3.4	0.1	-0.4	-0.8	1.9	0.5
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	7.6	-2.8	-1.7	1.4	1.3	-0.6
Pain experienced in last month	0.3	0.6	1.3	0.6	-0.0	0.3	1.2	1.0
Supplements: Calcium	1.0	1.1	2.2	0.6	1.2	1.5	1.1	-0.3
Basal cell carcinoma (self-reported)	0.7	0.8	3.2	-0.5	-0.5	-0.5	-1.8	0.1
Heart attack/myocardial infarction (self-reported)	1.3	1.6	3.9	-0.6	-1.7	-0.9	-0.2	-2.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.1	-0.2	-0.1	-0.9	0.8	1.4
Heart disease (siblings)	0.4	0.5	1.1	-1.1	0.7	0.3	0.1	-1.0
Alcohol drinker status: Previous	2.4	2.7	4.8	-2.2	-1.5	-2.0	-1.2	-1.1
Pack years of smoking	0.5	0.7	1.3	-1.0	-1.1	-0.1	1.1	0.2
Impedance of whole body	0.7	3.4	10.8	1.1	1.6	1.1	1.2	3.3
Leg fat mass (left)	1.2	4.6	9.1	-3.0	-1.2	1.6	2.7	1.7
Arm predicted mass (left)	1.1	5.5	8.1	-2.6	-1.6	-2.9	-1.8	-2.6