TWAS hub - C19orf50

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0240	0.0122	5.9e-06	0.038	0.031	0.027	NA	0.035	2.2e-08	5.2e-07	2.8e-06	NA	8.8e-08
2	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1210	0.0610	1.4e-03	0.000	0.008	0.012	NA	0.009	3.1e-01	1.0e-01	6.5e-02	NA	9.3e-02
3	TCGA	Brain Lower Grade Glioma	0.0663	0.0334	2.8e-04	0.001	0.036	0.021	NA	0.012	2.3e-01	5.6e-05	1.5e-03	NA	1.6e-02
4	TCGA	Ovarian Serous Cystadenocarcinoma	0.0430	0.0270	8.5e-03	0.012	0.025	0.001	NA	0.006	5.1e-02	8.3e-03	2.7e-01	NA	1.1e-01
5	TCGA	Prostate Adenocarcinoma	0.0430	0.0307	1.0e-02	0.016	0.010	0.025	NA	0.020	8.1e-03	2.8e-02	1.1e-03	NA	3.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Breast Cancer	8.2	19.7	40.4	-1.3	-6.2	-6.4	2.2	-3.5
Family relationship satisfaction	4.8	5.9	7.7	2.5	2.7	2.8	1.4	2.5
Commuting to job workplace: Walk	4.7	5.1	11.4	-3.1	-0.5	-1.0	-3.4	-1.7
Depression (self-reported)	4.1	4.9	8.0	-2.3	-2.1	-1.8	-1.8	-2.8
Alcohol drinker status: Never	4.1	4.9	11.7	-2.1	-1.9	-2.1	-0.5	-3.4
Mother’s age at death	3.7	4.6	6.9	-2.4	-2.1	-2.3	-0.9	-2.6
Medication: Atorvastatin	3.4	4.2	10.3	-1.5	-1.2	-3.2	0.2	-2.6
Length of working week for main job	3.3	3.6	6.0	2.4	1.5	0.1	2.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	3.0	6.8	9.5	-3.1	-2.9	-2.6	-2.1	-2.2
Blood Red Count	2.7	25.8	50.3	-4.5	-5.1	-7.1	-1.7	-5.4
Supplements: Glucosamine	2.7	3.5	6.5	1.3	2.5	2.6	-0.4	1.8
Ever had prostate specific antigen (PSA) test	2.7	3.1	5.4	1.3	2.3	2.2	0.0	1.9
Qualifications: CSEs or equivalent	2.4	3.1	8.1	-1.4	-2.8	-1.7	-0.4	-1.7
Multivitamins +/- minerals	2.3	2.9	4.8	-2.2	-0.5	-1.6	-1.7	-2.0
Number of children fathered	2.3	2.6	6.3	2.1	0.1	-0.4	2.5	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	7.6	-1.9	-0.4	-0.3	-2.8	-1.4
Time employed in main current job	2.2	2.5	4.9	2.2	1.0	0.9	2.0	1.4
Mood swings	2.2	4.0	8.4	-2.6	0.6	-1.3	-2.9	-1.5
Hearing difficulty/problems with background noise	2.1	3.3	5.8	0.9	2.4	2.3	-0.8	2.1
Handedness (chirality/laterality): Left-handed	2.1	2.5	5.4	-2.3	0.0	-1.0	-2.3	-0.9
Pulse rate	2.0	3.4	7.2	2.7	0.9	1.1	2.7	0.8
HDL Cholesterol	1.9	3.1	8.2	-2.3	-0.5	-0.7	-2.9	-1.1
Ever had hysterectomy (womb removed)	1.9	2.2	5.3	1.2	-2.3	-0.6	2.0	-0.1
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.7	2.2	-0.3	0.9	1.8	1.4
Friendships satisfaction	1.9	2.4	7.6	0.8	2.8	1.4	0.1	1.3
Qualifications: nursing, teaching	1.9	3.0	5.3	1.7	1.9	2.3	0.4	1.7
Number of operations (self-reported)	1.9	2.7	4.7	0.8	-1.8	-2.1	2.2	-0.9
Average weekly spirits intake	1.8	2.3	7.3	1.6	-0.3	-0.5	2.7	1.1
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	4.8	0.1	-2.2	-1.6	0.8	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.1	6.5	-2.5	-2.1	-1.5	-2.3	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.7	4.4	-2.1	-0.6	-1.6	-1.8	-1.8
Pulse wave reflection index	1.8	2.2	6.0	-1.4	-2.5	-1.4	-0.5	-0.9
Basal cell carcinoma (self-reported)	1.8	2.1	5.6	-1.2	-0.5	-2.4	0.6	-1.8
Heel T-Score	1.7	13.3	29.8	-2.9	-5.5	-4.1	-1.6	-3.0
Alcohol intake versus 10 years previously	1.7	2.5	3.6	-1.9	-1.0	-1.6	-1.8	-1.5
Worrier / anxious feelings	1.7	3.3	7.4	-2.7	0.5	-1.5	-2.1	-1.5
Noisy workplace	1.7	2.1	5.9	-0.8	-2.4	-1.7	0.2	-1.0
Diabetes (father)	1.6	2.0	6.1	-1.3	1.1	0.2	-2.5	-0.9
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	5.9	-0.5	2.4	1.7	-1.9	0.5
Ever highly irritable/argumentative for 2 days	1.6	1.9	5.0	-1.8	0.0	-0.2	-2.2	-1.0
Crohns Disease (2017)	1.5	3.3	9.4	1.0	-3.1	-0.9	2.3	-0.4
Lung FVC	1.5	7.6	11.7	-2.4	-3.3	-3.4	-1.1	-2.9
Serious illness, injury or assault to yourself	1.5	1.9	3.2	-1.8	0.4	-1.1	-1.7	-1.4
Number of live births	1.5	2.1	4.1	0.6	2.0	1.9	0.3	1.5
Pulse wave peak to peak time	1.5	1.7	4.5	0.2	2.1	1.6	-1.2	0.3
Number of full sisters	1.5	1.9	3.3	1.8	0.8	0.8	1.6	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.1	4.6	-1.9	-1.6	-1.8	-1.3	-2.1
Mean Putamen Volume	1.4	1.5	2.4	1.6	0.8	1.4	1.3	1.0
Headache pain in last month	1.4	2.3	4.3	-1.8	-1.2	-1.2	-1.0	-2.1
Leg pain on walking	1.4	1.7	3.6	1.1	1.9	1.5	-0.4	1.2
Long-standing illness, disability or infirmity	1.4	2.1	6.9	0.2	2.6	1.4	-0.6	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.6	1.6	0.0	1.1	1.4	1.2
Risk taking	1.4	2.0	3.2	-1.7	-1.7	-1.8	-0.6	-0.9
Alzheimer’s Disease (in father)	1.3	1.4	4.0	-1.1	1.3	0.4	-2.0	0.5
Lupus	1.3	2.0	5.3	0.1	2.3	1.8	-0.9	1.0
Allergy or Eczema	1.3	3.4	9.7	0.0	3.1	2.1	-1.4	0.9
Vitamin and mineral supplements	1.3	1.8	2.9	1.6	0.2	1.7	0.7	1.7
Supplements: Zinc	1.3	1.4	1.8	1.4	0.9	1.3	1.2	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.5	0.6	1.9	1.8	-0.3	1.1
Chronic bronchitis/emphysema (father)	1.3	1.6	4.4	-1.5	-0.7	-0.4	-2.1	-0.8
Supplements: Vitamin C	1.3	1.5	3.0	-1.4	-0.2	-1.6	-0.3	-1.7
Illnesses of siblings: Diabetes	1.3	1.7	4.3	0.1	2.1	1.1	-1.5	0.7
Myopia	1.3	2.0	3.2	-1.8	-0.6	-0.8	-1.7	-1.7
Crohns Disease (2012)	1.2	2.0	4.5	1.5	-2.1	0.2	1.8	0.1
Fed-up feelings	1.2	2.1	5.2	-1.0	2.1	0.4	-2.3	-0.1
Medication: Levothyroxine sodium	1.2	2.1	4.0	1.4	1.5	1.3	0.7	2.0
Pain all over the body in last month	1.2	1.3	3.8	-0.3	2.0	0.8	-1.2	0.8
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	6.9	-1.5	0.3	0.5	-2.6	0.2
Glaucoma (self-reported)	1.2	1.4	2.2	-1.2	-0.2	-1.5	-1.3	-1.3
Gout (self-reported)	1.2	1.7	3.5	1.5	-0.1	1.9	0.4	1.6
Exposure to tobacco smoke outside home	1.2	1.6	2.9	1.0	1.7	1.2	0.6	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.9	0.9	1.7	1.2	-0.2	1.4
Alcohol intake frequency.	1.2	2.8	6.9	-1.5	-0.4	-2.2	-0.2	-2.6
Heart attack/myocardial infarction (self-reported)	1.2	1.5	4.0	1.2	-1.4	-0.2	2.0	-0.6
Depressed Affect (Nagel 2018)	1.1	2.2	4.9	-1.1	2.2	0.5	-2.2	-0.0
Age at First Birth	1.1	1.7	2.2	-1.4	-1.4	-0.3	-1.5	-1.5
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.7	-1.0	0.7	-1.6	-0.9	-1.0
Number of incorrect matches in round	1.1	1.9	4.6	1.8	0.8	0.7	2.2	0.6
Nervous feelings	1.1	2.1	6.1	0.4	2.5	1.7	-0.2	1.0
Hair/balding pattern: Pattern 2	1.1	1.3	4.7	-1.0	0.7	0.6	-2.2	-0.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.9	-1.8	0.2	0.1	-2.4	-0.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.7	1.3	1.5	1.3	0.6	2.2
Comparative body size at age 10	1.1	2.9	5.1	-1.6	-0.4	-2.2	-1.5	-2.3
Average weekly red wine intake	1.1	1.6	4.7	1.1	-1.3	0.4	2.2	0.5
Miserableness	1.1	1.8	5.3	-1.3	1.3	0.2	-2.3	-0.6
Commuting to job workplace: Public transport	1.1	1.3	2.6	-1.6	1.1	-1.2	-1.2	-0.4
Ever smoked	1.1	1.9	3.5	1.7	0.7	0.2	1.9	1.6
Average weekly beer plus cider intake	1.1	1.6	3.1	1.8	1.0	1.5	0.6	1.1
Cholesterol lowering medication	1.1	1.6	4.4	-0.5	-1.0	-2.1	0.6	-1.5
Intelligence (Savage-Jansen 2018)	1.0	3.2	6.7	0.7	2.6	2.5	-0.8	1.4
Coronary Artery Disease (CAD)	1.0	1.1	1.7	-1.0	-1.3	-1.2	0.3	-1.2
Waist Hip Ratio (WHR)	1.0	4.4	9.4	1.0	3.1	2.3	-0.8	2.4
Hypothyroidism (self reported)	1.0	2.3	3.6	1.8	1.2	1.5	0.9	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.7	-1.3	1.3	0.5	-1.9	-0.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.0	-1.3	-1.4	-0.6	-1.2	-0.8
Heart attack	1.0	1.3	3.7	1.1	-1.2	-0.1	1.9	-0.4
Migraine (self-reported)	1.0	1.3	2.9	-1.2	-0.5	-1.7	-0.8	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.0	1.0	1.4	-0.2	1.7	0.1
Prostate Cancer	0.9	1.3	3.6	-1.0	-1.9	-1.2	-0.2	-0.5
Number of treatments/medications taken	0.9	1.6	2.8	-1.7	-0.2	-1.2	-1.6	-1.1
Father’s age at death	0.9	1.2	4.2	-0.5	-2.1	-0.8	0.2	-1.0
Happiness	0.9	1.1	3.3	0.5	1.8	1.1	0.0	0.9
Exposure to tobacco smoke at home	0.9	1.0	2.3	0.7	1.4	1.5	-0.3	0.3
Worry too long after embarrassment	0.9	1.5	3.6	-1.1	1.9	-0.3	-1.6	0.1
Medication: Omeprazole	0.9	1.1	3.1	1.1	1.8	0.1	1.0	0.2
Mean time to correctly identify matches	0.9	1.8	5.4	0.8	2.3	1.1	-0.2	1.3
Illnesses of father: Heart disease	0.9	1.2	2.5	1.3	0.8	1.6	0.7	0.9
Hearing aid user	0.9	1.0	3.0	0.3	0.9	1.1	-0.3	1.7
Age started oral contraceptive pill	0.9	1.1	3.0	-1.1	0.4	0.6	-1.7	0.8
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.6	-0.5	1.4	1.6	-2.1	0.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.2	0.3	1.1	1.5	-0.9	0.4
Systolic Blood Pressure	0.8	4.1	11.3	-2.5	0.8	-0.1	-3.4	-1.5
Sensitivity / hurt feelings	0.8	1.4	2.5	0.9	1.2	1.6	-0.1	1.5
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.2	-0.9	0.6	0.8	-1.8	-0.9
Medication: Co-codamol	0.8	0.9	1.5	0.9	1.1	0.9	-0.2	1.2
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.3	-0.8	0.6	-0.1	-1.8	-0.1
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.7	-0.6	1.9	1.4	-1.5	0.2
Had other major operations	0.8	0.9	2.7	-0.0	-1.2	-1.7	0.6	-0.5
Pulse wave Arterial Stiffness index	0.8	0.9	2.2	-0.1	-1.5	-1.1	1.0	0.0
Medication: Ibuprofen	0.8	1.0	2.5	-1.2	0.9	0.1	-1.6	-0.7
Heart disease (mother)	0.8	0.9	2.4	0.9	0.8	1.6	0.1	0.9
Loneliness, isolation	0.8	1.1	2.2	-1.5	0.4	-1.1	-1.4	-0.3
Diabetes diagnosed by doctor	0.8	1.4	2.5	1.6	1.6	0.3	1.2	0.6
Number of self-reported non-cancer illnesses	0.8	1.3	2.9	-0.9	-0.9	-1.7	-0.4	-1.4
Wears glasses or contact lenses	0.8	1.0	2.6	0.7	1.6	-0.3	1.2	0.3
Heart disease (siblings)	0.8	1.0	2.6	-0.1	-1.6	-1.0	0.5	-1.0
Neuroticism (Nagel 2018)	0.7	1.7	5.9	-0.4	2.4	0.9	-1.3	0.4
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	3.2	-1.2	-0.3	-0.0	-1.8	0.1
Medication: Metformin	0.7	1.0	2.9	1.1	1.7	0.4	0.8	0.2
Past tobacco smoking	0.7	1.3	3.1	-1.4	0.4	0.5	-1.8	-1.0
Neuroticism score	0.7	1.6	3.3	-1.2	1.7	-0.0	-1.8	-0.1
Birth weight of first child	0.7	1.3	3.0	1.7	1.0	1.0	1.0	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.8	-1.3	0.2	-0.0	-1.3	-0.8
Health satisfaction	0.7	0.9	2.3	0.9	1.5	1.1	-0.2	0.6
Neck or shoulder pain in last month	0.7	1.0	3.0	-1.3	-0.3	-1.7	-0.3	-0.6
Overall health rating	0.7	1.5	3.5	-0.9	1.5	0.7	-1.9	-0.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.5	0.8	-0.7	0.9	1.0	1.2
Eye problems/disorders: Glaucoma	0.7	0.9	1.7	-0.9	0.0	-1.3	-1.0	-0.8
Medication: Paracetamol	0.7	1.1	2.4	0.1	1.4	1.5	-1.0	0.3
Irritability	0.7	1.2	2.2	-1.3	-0.1	-1.1	-1.5	-1.0
Worry (Nagel 2018)	0.6	1.3	4.7	0.1	2.2	1.0	-0.4	0.7
Alzheimer’s Disease (in mother)	0.6	0.7	2.5	0.5	0.5	0.6	0.1	1.6
Irritable Bowel Disease (IBD)	0.6	1.5	3.1	1.0	-1.8	0.8	1.2	1.2
Ulcerative Colitis (UC)	0.6	1.1	3.1	0.4	-0.1	1.4	-0.1	1.8
Neuroticism	0.6	1.4	4.0	-0.4	2.0	0.9	-1.4	0.4
Impedance of leg (right)	0.6	3.1	7.6	1.4	0.9	2.8	0.9	2.0
High blood pressure (mother)	0.6	0.8	2.7	-0.6	0.9	-0.3	-1.6	0.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	-1.0	0.7	0.8	-1.3	0.1
Falls in the last year	0.6	0.8	1.5	-1.2	-0.4	-0.9	-1.2	-0.1
Hair/balding pattern: Pattern 3	0.6	0.9	2.0	-0.2	-0.8	-1.4	1.0	-1.0
Hair/balding pattern: Pattern 4	0.6	1.5	3.1	1.5	0.5	1.0	0.9	1.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.2	-0.6	-1.1	-0.9	-0.8	-1.1
Medication: Paracetamol	0.6	0.9	1.8	0.1	1.3	1.2	-1.0	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	-1.1	-0.8	-0.5	-0.9	-0.7
Had major operations	0.6	0.7	2.0	1.1	0.1	-0.3	1.4	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.3	-0.8	1.2	-0.6	-1.1	-0.4
Illnesses of father: None of the above (group 1)	0.6	0.8	1.6	-1.3	-0.6	-0.6	-1.0	-0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.8	-1.4	0.3	-0.5	-0.9	-1.0
Pain experienced in last month	0.6	1.1	3.5	1.0	-0.9	-0.3	1.9	-0.2
Bipolar Disorder (2018)	0.5	0.8	2.8	-0.5	1.7	-0.3	-0.6	-0.6
LDL Cholesterol	0.5	0.8	1.9	0.3	-1.4	-1.0	0.7	-0.7
Primary Biliary Cirrhosis	0.5	0.7	1.4	-1.1	0.0	-0.5	-1.2	-0.9
Triglycerides	0.5	0.9	2.0	1.1	-0.3	-1.1	1.4	-0.2
Smoking Status	0.5	1.1	2.3	1.2	-0.7	-0.2	1.5	1.0
Relative age of first facial hair	0.5	1.0	1.9	0.9	-0.8	0.3	1.4	1.3
Angina	0.5	0.7	1.9	-0.0	-1.4	-0.1	0.1	-1.2
Diabetes (mother)	0.5	0.7	1.8	0.8	0.2	1.3	-0.9	0.4
Pack years adult smoking proportion	0.5	0.7	1.3	0.1	-1.1	-1.1	0.7	-0.8
Maternal smoking around birth	0.5	0.7	1.8	0.4	-1.0	-0.7	1.4	0.3
Impedance of leg (left)	0.5	2.3	7.0	0.9	1.0	2.6	0.5	1.6
Alcohol usually taken with meals	0.5	0.8	2.1	-0.2	-1.4	-0.3	1.1	-0.8
Medication: Simvastatin	0.5	0.8	2.2	1.1	-0.4	-0.3	1.5	0.3
Fluid intelligence score	0.5	1.0	3.1	0.0	1.8	0.7	-0.8	0.8
Medication: Cholesterol lowering	0.5	0.8	2.4	1.1	-0.6	-0.2	1.5	0.2
Medication: Lansoprazole	0.5	0.6	1.4	-1.0	0.5	-1.2	-0.4	-0.4
Lung cancer (father)	0.5	0.6	1.3	-0.6	-0.8	-0.9	-0.1	-1.2
Birth weight	0.5	1.2	3.5	-0.9	-0.3	-1.2	-0.1	-1.9
Emphysema/chronic bronchitis	0.5	0.6	1.0	0.6	0.9	0.5	0.5	1.0
Medication: Blood pressure	0.5	0.9	2.7	1.1	0.1	-0.4	1.6	0.5
Angina (self-reported)	0.5	0.7	2.0	-0.0	-1.4	-0.0	-0.0	-1.2
Medication: Seretide 50 evohaler	0.5	0.6	2.1	0.4	0.2	-0.4	0.8	1.4
Comparative height size at age 10	0.5	2.6	6.0	-0.3	2.4	1.5	-1.4	1.6
Smoking status: Previous	0.5	0.7	1.3	1.0	-0.4	-0.4	1.1	0.9
Mineral and other dietary supplements	0.5	0.7	1.2	1.0	-0.4	0.7	0.8	1.1
Alcohol drinker status: Previous	0.5	0.6	2.0	0.4	0.4	-0.7	1.4	0.2
Pack years of smoking	0.5	0.7	1.3	0.4	-0.9	-1.1	1.1	-0.7
Bipolar Disorder or Schizophrenia	0.4	0.9	2.6	-0.9	1.6	-0.1	-0.8	-0.7
Depression (Nagel 2018)	0.4	0.6	1.5	-0.1	1.2	1.0	-0.6	0.1
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	0.7	0.7	0.9	0.1	0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	2.5	0.1	0.2	0.1	-0.6	1.6
HbA1C	0.4	0.5	1.2	0.6	1.1	0.7	0.0	0.4
Neuroticism (2016)	0.4	0.5	1.2	-1.0	0.1	-0.4	-1.1	-0.5
Blood White Count	0.4	3.2	8.4	1.7	-1.6	-1.4	2.9	-0.1
Height	0.4	8.2	15.8	-1.2	4.0	3.7	-2.8	1.5
Lung FEV1/FVC ratio	0.4	1.9	5.3	-1.6	0.1	0.3	-2.3	-1.3
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	-0.4	-0.4	-1.3	0.6	-0.3
Systolic blood pressure, automated reading	0.4	1.2	2.8	-0.8	1.7	0.1	-1.6	-0.2
Medication for hormone replacement therapy	0.4	0.4	1.2	-0.7	-0.4	-0.3	-1.1	-0.2
Average weekly fortified wine intake	0.4	0.4	1.4	-0.4	-1.2	-0.1	-0.3	-0.7
High blood pressure	0.4	1.0	2.4	1.0	-0.5	-1.1	1.5	-0.1
Financial difficulties in last 2 years	0.4	0.5	2.0	-0.1	1.4	0.3	-0.8	-0.0
Diabetes (self-reported)	0.4	0.7	1.5	1.2	0.8	0.2	1.1	0.1
Medication: Ramipril	0.4	0.5	1.5	0.2	-1.2	0.1	0.2	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.4	-0.7	-0.0	0.3	-1.2	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	-0.6	0.5	0.3	-1.3	-0.1
Standing height	0.4	4.4	8.8	-1.1	3.0	2.5	-2.1	1.1
Loud music exposure frequency	0.4	0.4	1.9	-0.4	0.3	0.1	-1.4	0.0
Arm fat-free mass (right)	0.4	2.0	5.8	-0.9	1.4	1.1	-2.4	-0.0
Shortness of breath walking on level ground	0.4	0.4	0.8	0.8	0.2	0.9	-0.1	0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.5	-0.8	-0.3	-0.2	-1.2	0.4
Pulse rate, automated reading	0.4	1.4	2.8	1.0	1.5	0.2	0.9	1.7
Medication: Aspirin	0.4	0.5	2.0	-0.1	-1.4	-0.6	0.5	-0.4
Knee pain experienced in last month	0.4	0.6	1.3	1.1	0.3	1.1	0.5	0.6
Hypertension (Self-reported)	0.4	1.1	2.8	1.1	-0.6	-0.9	1.7	-0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.8	-0.3	1.3	1.4	-1.0	0.3
Leg fat-free mass (right)	0.4	2.2	5.1	-1.7	0.8	-1.0	-2.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.2	1.0	-0.2	0.3	1.1	0.8
Leg predicted mass (right)	0.4	2.1	4.8	-1.7	0.9	-1.0	-2.2	-1.1
Arm fat-free mass (left)	0.4	1.8	3.9	-0.5	2.0	1.0	-1.9	0.3
Fractured/broken bones in last 5 years	0.4	0.5	2.4	0.0	1.6	-0.4	-0.1	-0.2
Ever depressed for a whole week	0.4	0.5	0.8	-0.7	-0.9	0.4	-0.9	0.2
Rheumatoid Arthritis	0.3	0.4	1.0	-0.3	-1.0	-0.5	0.2	-0.6
Schizophrenia (2014)	0.3	0.7	2.0	-0.6	1.4	0.5	-1.0	0.0
Ulcerative Colitis	0.3	0.5	0.8	-0.9	-0.5	0.5	-0.7	0.9
Cardiovascular Disease	0.3	1.1	2.7	1.2	-0.0	-1.0	1.6	-0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	0.5	-0.3	-0.9	0.8	-0.8
Tanning	0.3	3.9	7.2	2.2	1.4	0.9	2.7	2.1
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.4	-0.6	-0.6	0.0	-0.9
Relative age voice broke	0.3	0.4	0.9	0.4	-0.4	1.0	0.2	0.9
Taking other prescription medications	0.3	0.5	1.8	-0.8	0.2	-0.4	-1.3	0.2
Age when periods started (menarche)	0.3	0.8	1.7	0.8	-1.0	0.4	1.3	0.7
Stomach or abdominal pain in last month	0.3	0.3	0.7	-0.8	0.4	0.1	-0.8	-0.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.8	-0.4	0.9	0.4	-0.6	-0.0
Medication: Atenolol	0.3	0.4	0.7	0.2	-0.8	-0.8	0.7	-0.4
Qualifications: None of the above	0.3	0.7	1.7	0.8	0.0	-1.1	1.3	0.3
Allergy	0.3	0.6	2.3	0.3	-1.5	-0.6	0.6	-0.1
Trunk fat-free mass	0.3	1.5	4.0	-0.9	1.5	0.7	-2.0	-0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.7	-1.2	-0.6	-0.3	-1.3	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.9	-1.2	0.2	0.6	-1.4	-0.3
Asthma	0.3	0.5	1.1	-1.0	0.4	-1.1	-0.6	0.3
Trunk predicted mass	0.3	1.5	4.0	-0.9	1.4	0.7	-2.0	-0.1
Tense / ‘highly strung’	0.3	0.5	1.6	-0.3	-0.3	-1.3	0.4	-0.7
High blood pressure (siblings)	0.3	0.4	1.4	0.4	1.2	-0.4	0.3	0.2
Age at first live birth	0.3	0.4	1.0	-0.7	-0.7	-0.1	-0.5	-1.0
Medication: Allopurinol	0.3	0.4	0.6	0.2	-0.8	0.8	-0.2	0.8
Arm predicted mass (right)	0.3	1.7	4.3	-0.6	1.5	1.2	-2.1	0.1
Suffer from ‘nerves’	0.3	0.5	1.4	-0.6	1.2	0.3	-0.7	-0.0
Age at last live birth	0.3	0.4	1.3	-0.5	0.0	1.1	-0.7	0.1
Whole body fat-free mass	0.3	1.5	4.4	-1.1	1.2	0.1	-2.1	-0.4
Back pain experienced in last month	0.3	0.5	0.8	0.1	0.7	0.7	-0.9	0.6
Breast cancer (self-reported)	0.3	0.4	1.2	-0.3	1.1	0.1	-0.7	0.1
Medication: Aspirin	0.3	0.4	0.9	0.6	-0.8	-0.1	0.9	-0.0
Whole body water mass	0.3	1.4	4.1	-0.9	1.4	0.4	-2.0	-0.2
Guilty feelings	0.3	0.4	1.4	-0.3	1.2	-0.4	-0.6	0.4
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.6	-0.4	0.5	-0.8	-0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.8	0.9	0.0	-0.1	0.9	0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.7	-1.0	0.4	0.8	-1.3	-0.2
Arm predicted mass (left)	0.3	1.6	3.7	-0.4	1.9	0.9	-1.8	0.3
Schizophrenia (2018)	0.2	0.3	0.6	-0.7	0.8	0.2	-0.5	-0.4
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	-0.1	-0.6	-0.7	-0.1	-0.5
Blood Platelet Count	0.2	2.0	3.5	1.4	-1.6	-0.5	1.9	1.4
BMI	0.2	1.3	4.8	2.2	1.0	0.1	0.9	0.3
Respiratory disease	0.2	0.4	1.2	-0.8	0.4	-1.1	-0.1	0.1
Chronotype (morning person)	0.2	0.4	0.9	-1.0	0.4	-0.2	-0.9	-0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.9	-0.0	0.6	0.1	0.4
Severe depression (siblings)	0.2	0.2	0.9	-0.1	-1.0	-0.1	-0.1	-0.0
Leg fat-free mass (left)	0.2	1.1	3.1	-1.0	0.8	-0.6	-1.8	-0.6
Hand grip strength (right)	0.2	0.4	1.0	-0.5	-0.0	0.0	-0.9	-1.0
Sitting height	0.2	1.6	3.0	-0.9	1.5	1.7	-1.3	0.3
Leg predicted mass (left)	0.2	1.2	3.2	-1.1	0.8	-0.7	-1.8	-0.7
Waist circumference	0.2	0.9	3.1	0.6	1.8	0.4	-0.5	0.8
Had menopause	0.2	0.2	0.7	-0.3	0.3	0.0	-0.2	0.9
Illnesses of siblings	0.2	0.3	1.0	-0.5	-1.0	-0.1	-0.0	-0.1
Arm fat percentage (right)	0.2	0.7	2.5	0.3	-0.2	-1.6	0.5	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.3	0.9	-0.1	0.6	0.5	-1.0	0.4
Illnesses of mother	0.2	0.2	0.4	-0.4	-0.3	-0.4	0.4	-0.6
Breastfed as a baby	0.2	0.3	0.6	-0.2	0.8	-0.3	0.5	0.7
Medication: Amlodipine	0.2	0.3	0.7	0.6	-0.5	0.2	0.8	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	-0.3	0.3	-0.9	0.4	0.5
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	-0.8	0.2	-0.2	-0.9	0.1
Eye problems/disorders: None of the above	0.2	0.2	0.6	0.5	-0.0	0.3	0.7	0.5
Chest pain or discomfort	0.2	0.3	0.8	0.6	-0.4	0.9	0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	-0.1	0.5	0.4	-0.7	0.4
Arm fat percentage (left)	0.2	0.6	2.2	0.2	-0.4	-1.5	0.4	-0.7
Ever had bowel cancer screening	0.2	0.2	0.5	0.7	0.4	0.3	0.6	0.2
Medication for cholesterol	0.2	0.3	0.5	-0.7	0.7	0.2	-0.6	0.0
Asthma (self-reported)	0.2	0.4	0.9	-0.9	0.3	-0.9	-0.6	0.2
Osteoporosis (self-reported)	0.2	0.3	0.7	0.3	-0.5	0.5	0.8	0.3
Osteoarthritis (self-reported)	0.2	0.3	0.7	0.1	0.2	0.9	-0.8	0.4
Financial situation satisfaction	0.2	0.2	0.7	-0.4	0.4	-0.8	-0.2	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	-0.6	-0.2	-0.4	-0.6	-0.2
Medication: Bendroflumethiazide	0.2	0.3	0.9	0.9	-0.5	0.2	0.5	-0.0
Medication: Lisinopril	0.2	0.3	0.5	0.5	0.7	-0.1	0.4	0.7
Basal metabolic rate	0.2	1.3	3.8	-1.0	1.3	0.1	-1.9	-0.4
Diastolic blood pressure, automated reading	0.2	0.6	1.0	0.8	-0.7	-0.7	1.0	0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	0.0	-0.4	-0.6	0.8	-0.3
Reaction Time	0.1	0.3	0.8	0.0	0.9	0.3	-0.6	0.1
Ovarian Cancer	0.1	0.1	0.2	0.2	-0.4	0.5	-0.3	-0.1
Fasting Glucose	0.1	0.1	0.2	-0.2	-0.5	0.4	-0.0	0.3
Blood Eosinophil Count	0.1	0.8	1.4	0.7	0.9	-1.0	1.2	0.5
Hair Pigment	0.1	4.1	12.4	-1.0	-3.5	-2.1	0.1	-1.6
Hand grip strength (left)	0.1	0.3	0.7	-0.4	0.2	-0.2	-0.9	-0.7
Body mass index (BMI)	0.1	0.3	1.1	0.4	0.0	-1.0	-0.1	-0.6
Trunk fat mass	0.1	0.2	0.9	0.3	0.9	0.0	-0.3	0.1
Forced vital capacity (FVC)	0.1	0.3	0.4	-0.7	-0.3	0.1	-0.6	-0.6
Mouth/teeth dental problems	0.1	0.1	0.3	-0.2	-0.2	-0.2	0.5	-0.2
Weight	0.1	0.5	1.6	-0.1	1.3	0.1	-1.0	-0.1
Impedance of arm (right)	0.1	0.6	1.0	-0.4	-0.8	-1.0	1.0	-0.0
Hip circumference	0.1	0.3	1.1	-0.1	-0.2	-1.1	-0.2	-0.6
Prospective memory result	0.1	0.1	0.3	0.0	-0.4	-0.3	-0.0	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.3	-0.7	0.2	0.3	-1.2	0.0
Impedance of arm (left)	0.1	0.6	1.6	-0.1	-1.0	-0.4	1.3	0.2
Arm fat mass (right)	0.1	0.2	0.8	0.1	0.4	-0.9	-0.3	-0.4
Peak expiratory flow (PEF)	0.1	0.3	0.5	-0.5	-0.7	-0.3	-0.1	-0.7
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.2	-0.3	-0.3	0.7	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.4	-0.3	0.5	0.6	-0.5	0.6
Leg fat percentage (right)	0.1	0.5	1.7	1.3	0.5	0.2	0.7	0.4
Number of full brothers	0.1	0.1	0.4	-0.1	-0.1	-0.0	-0.2	-0.6
Qualifications: College or University degree	0.1	0.3	0.8	-0.9	-0.7	0.2	-0.1	-0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.7	0.2	-0.2	-0.1	0.8	0.4
Leg fat mass (right)	0.1	0.2	0.7	0.3	0.8	-0.1	-0.5	0.1
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.2	0.3	0.4	-0.0	0.4
Medication: Gliclazide	0.1	0.2	0.5	-0.2	-0.0	0.2	-0.7	-0.5
Arm fat mass (left)	0.1	0.3	0.9	-0.2	0.1	-0.9	-0.5	-0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.4	-0.3	-0.4	0.6	-0.2	-0.1
Medication: Blood pressure	0.1	0.3	0.5	0.7	-0.7	0.1	0.5	-0.2
High cholesterol (Self-reported)	0.1	0.2	0.6	0.1	-0.1	-0.8	0.6	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.0	0.1	0.0	-0.4	-0.5
Leg fat percentage (left)	0.1	0.4	1.2	1.1	0.7	0.2	0.4	0.3
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.3	0.1	-0.1	-0.6	0.2
Commuting to job workplace: Cycle	0.1	0.2	0.5	-0.3	-0.1	0.4	-0.4	-0.7
Supplements: Calcium	0.1	0.1	0.3	0.6	-0.2	0.2	0.2	0.2
Impedance of whole body	0.1	0.4	0.8	0.1	-0.2	0.9	0.7	0.7
Leg fat mass (left)	0.1	0.3	0.8	0.2	0.9	-0.1	-0.6	-0.1
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Trunk fat percentage	0.0	0.1	0.3	0.5	0.6	-0.3	0.2	0.1
Current tobacco smoking	0.0	0.1	0.1	-0.1	-0.2	-0.2	-0.3	0.3
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.2	-0.1	0.0	0.1	-0.1	0.4
Body fat percentage	0.0	0.1	0.3	0.5	0.5	-0.3	0.2	0.0
Whole body fat mass	0.0	0.1	0.3	0.1	0.6	-0.3	-0.4	-0.2
Smoking status: Current	0.0	0.0	0.1	-0.0	-0.3	-0.1	-0.2	0.3

Hub : Genes

C19orf50

Models

Trait associations