[Hub]/) : Traits : Irritable Bowel Disease (IBD) : ← →

chr5:129,797,129-132,900,729

Best TWAS P=4.98e-28 · Best GWAS P=3.67e-27 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-5.4	-5.8	7.2e-09	-0.52	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	9.1	-10.1	6.7e-24	-0.78	0.11	0.83	FALSE
3	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-5.8	5.8	8.6e-09	0.66	0.99	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-5.8	5.8	7.7e-09	0.66	0.53	0.13	FALSE
5	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-5.7	5.8	4.9e-09	0.66	0.64	0.16	FALSE
6	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	8.3	8.3	1.5e-16	0.77	0.51	0.47	FALSE
7	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	7.8	7.8	8.5e-15	0.77	0.14	0.71	FALSE
8	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	7.9	7.8	6.3e-15	0.77	0.82	0.18	FALSE
9	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	-4.6	-5.8	7.6e-09	-0.39	0.52	0.12	FALSE
10	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	9.1	-9.7	4.7e-22	-0.82	0.52	0.48	FALSE
11	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	7.9	7.9	3.3e-15	0.77	0.54	0.46	FALSE
12	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-5.8	5.7	9.4e-09	0.67	1.00	0.00	FALSE
13	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	-5.8	5.5	3.3e-08	0.65	0.98	0.02	FALSE
14	GTEx	Brain Frontal Cortex BA9	AC034220.3	0.31	0.20	lasso	14	0.21	3.3e-06	-5.5	5.8	5.3e-09	0.70	0.46	0.44	FALSE
15	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-5.5	7.0	3.5e-12	0.73	0.32	0.40	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	SLC22A5	0.15	0.00	enet	24	0.05	1.4e-02	-5.5	6.0	2.3e-09	0.55	0.10	0.22	TRUE
17	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-5.6	5.8	6.2e-09	0.66	0.87	0.07	FALSE
18	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	9.0	-5.5	4.9e-08	-0.72	0.03	0.96	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	9.0	-7.3	2.7e-13	-0.74	0.05	0.89	FALSE
20	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-5.8	-5.8	7.0e-09	-0.52	0.84	0.02	FALSE
21	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-8.3	-9.3	1.6e-20	-0.79	1.00	0.00	FALSE
22	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	-5.5	5.5	3.3e-08	0.68	0.25	0.14	FALSE
23	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	9.0	-9.9	4.1e-23	-0.77	0.12	0.79	TRUE
24	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-5.9	6.0	2.7e-09	0.67	0.92	0.04	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-5.6	6.8	1.0e-11	0.63	0.40	0.41	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	UQCRQ	0.21	0.01	enet	30	0.04	2.0e-02	-8.4	-6.6	4.5e-11	-0.42	0.08	0.21	FALSE
27	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	8.3	6.8	1.3e-11	0.69	0.94	0.06	FALSE
28	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	9.0	-9.3	1.5e-20	-0.82	0.95	0.05	FALSE
29	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	-5.5	5.6	2.6e-08	0.66	0.97	0.01	FALSE
30	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	8.3	8.2	1.8e-16	0.77	0.43	0.55	FALSE
31	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-5.7	6.2	6.8e-10	0.72	0.88	0.11	FALSE
32	GTEx	Lung	RAD50	0.12	0.09	lasso	11	0.08	1.3e-06	-5.2	-5.3	1.4e-07	-0.44	0.92	0.02	FALSE
33	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	9.0	-9.0	1.7e-19	-0.84	0.70	0.30	FALSE
34	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-5.8	6.3	2.5e-10	0.68	1.00	0.00	FALSE
35	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-5.8	7.7	2.0e-14	0.69	0.20	0.21	FALSE
36	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-5.7	5.2	2.4e-07	0.68	0.94	0.05	FALSE
37	GTEx	Nerve Tibial	SLC22A5	0.17	0.11	lasso	9	0.09	5.5e-07	-4.0	-6.5	6.0e-11	-0.43	0.71	0.25	FALSE
38	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-5.7	5.7	1.2e-08	0.66	1.00	0.00	FALSE
39	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	6.1	5.7	9.7e-09	0.69	0.89	0.10	FALSE
40	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	-5.6	7.0	2.5e-12	0.55	0.35	0.21	FALSE
41	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-5.3	5.8	8.8e-09	0.63	0.70	0.04	FALSE
42	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-5.9	6.7	1.8e-11	0.70	0.65	0.34	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	9.0	-9.5	3.2e-21	-0.78	0.45	0.22	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	-9.2	-8.6	9.5e-18	-0.70	0.14	0.14	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-5.6	-7.2	6.2e-13	-0.78	0.35	0.64	FALSE
46	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	8.3	-9.2	2.5e-20	-0.83	0.13	0.87	FALSE
47	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	9.1	-8.6	5.6e-18	-0.84	1.00	0.00	FALSE
48	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	9.0	8.3	1.2e-16	0.81	0.07	0.82	FALSE
49	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-8.3	-7.3	2.0e-13	-0.71	0.14	0.21	FALSE
50	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-5.4	6.4	1.7e-10	0.63	1.00	0.00	FALSE
51	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	8.3	9.5	2.7e-21	0.83	0.08	0.91	FALSE
52	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-5.8	5.8	8.0e-09	0.66	0.89	0.01	FALSE
53	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	7.9	8.2	3.4e-16	0.76	0.39	0.52	FALSE
54	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	6.1	-7.2	8.7e-13	-0.73	0.05	0.89	FALSE
55	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	-4.0	-8.0	1.2e-15	-0.66	0.66	0.31	FALSE
56	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	7.9	9.1	1.4e-19	0.77	0.24	0.68	FALSE
57	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-8.3	-9.4	3.4e-21	-0.69	0.16	0.74	FALSE
58	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	9.0	-9.0	3.0e-19	-0.84	0.84	0.16	FALSE
59	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	9.3	-9.9	3.2e-23	-0.77	0.14	0.85	FALSE
60	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-5.2	6.4	1.2e-10	0.61	0.18	0.69	FALSE
61	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	7.9	5.9	4.2e-09	0.67	0.97	0.03	FALSE
62	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	6.0	-6.1	1.3e-09	-0.65	0.91	0.03	FALSE
63	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	7.7	-7.7	1.5e-14	-0.70	0.51	0.47	FALSE
64	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	9.0	-9.0	3.0e-19	-0.84	0.44	0.56	FALSE
65	NTR	Blood	C5orf56	0.01	0.01	blup	439	0.01	1.7e-03	-8.7	-8.3	9.6e-17	-0.49	0.23	0.16	FALSE
66	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	-5.2	9.5	1.4e-21	0.67	0.74	0.26	FALSE
67	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	7.7	-8.2	3.7e-16	-0.69	0.07	0.92	FALSE
68	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	9.8	-11.0	5.0e-28	-0.76	0.03	0.96	TRUE
69	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-5.8	-6.1	8.1e-10	-0.57	1.00	0.00	FALSE
70	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-5.8	-7.7	2.0e-14	-0.78	1.00	0.00	FALSE
71	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	9.0	-8.3	7.6e-17	-0.80	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	7.9	6.2	6.4e-10	0.65	0.04	0.95	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-5.8	-6.8	1.2e-11	-0.56	1.00	0.00	TRUE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	9.0	-6.3	2.3e-10	-0.71	0.44	0.13	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-5.4	-5.9	2.8e-09	-0.62	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	-6.7	-8.9	4.9e-19	-0.59	0.42	0.29	FALSE
77	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-8.3	-9.2	5.0e-20	-0.78	0.03	0.91	FALSE
78	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A4	0.02	0.02	lasso	1	0.02	3.0e-03	-5.6	-5.6	1.9e-08	-0.57	0.23	0.12	FALSE
79	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-5.7	-7.3	2.6e-13	-0.76	0.82	0.17	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-5.8	-6.0	1.6e-09	-0.52	0.16	0.72	FALSE
81	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-5.6	-5.6	2.1e-08	-0.66	0.46	0.04	FALSE
82	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A5	0.06	0.04	blup	93	0.04	8.9e-06	-0.4	5.4	6.2e-08	0.42	0.50	0.26	FALSE
83	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	-5.4	-5.4	5.8e-08	-0.55	0.13	0.06	FALSE
84	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf56	0.03	0.01	blup	98	0.02	4.2e-03	-5.1	8.4	4.8e-17	0.73	0.09	0.42	TRUE
85	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	-5.3	-5.8	6.5e-09	-0.54	0.04	0.38	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	LYRM7	0.03	0.01	enet	10	0.02	7.5e-04	-4.2	5.3	1.1e-07	0.24	0.01	0.80	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-8.3	-8.6	1.1e-17	-0.65	0.12	0.46	FALSE
88	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-3.7	-7.6	2.7e-14	-0.68	0.06	0.72	FALSE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-5.4	-6.3	2.6e-10	-0.69	0.65	0.33	FALSE
90	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	-8.3	-8.0	1.2e-15	-0.52	0.10	0.65	FALSE
91	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-5.8	-6.5	7.0e-11	-0.56	1.00	0.00	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-5.7	-8.0	9.0e-16	-0.74	0.06	0.94	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	-4.6	-5.6	1.9e-08	-0.41	0.96	0.01	FALSE
94	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	-6.1	-6.6	4.5e-11	-0.49	0.09	0.15	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-5.4	5.4	7.3e-08	0.59	0.66	0.26	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	10.6	9.0	1.9e-19	0.87	0.00	0.90	TRUE
97	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	7.9	8.4	4.8e-17	0.76	0.61	0.39	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-8.3	-8.3	7.5e-17	-0.70	0.02	0.60	FALSE