[Hub]/) : Traits : Irritable Bowel Disease (IBD) :

chr5:129,797,129-132,900,729

Best TWAS P=4.98e-28 · Best GWAS P=3.67e-27 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PDLIM4 0.11 0.18 lasso 5 0.18 8.0e-21 -5.4 -5.8 7.2e-09 -0.52 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous SLC22A5 0.05 0.04 lasso 4 0.04 4.2e-04 9.1 -10.1 6.7e-24 -0.78 0.11 0.83 FALSE
3 GTEx Adipose Subcutaneous AC034220.3 0.11 0.11 lasso 10 0.09 4.8e-08 -5.8 5.8 8.6e-09 0.66 0.99 0.00 FALSE
4 GTEx Adipose Visceral Omentum AC034220.3 0.10 0.09 lasso 7 0.08 7.3e-05 -5.8 5.8 7.7e-09 0.66 0.53 0.13 FALSE
5 GTEx Adrenal Gland AC034220.3 0.12 0.11 lasso 16 0.08 7.7e-04 -5.7 5.8 4.9e-09 0.66 0.64 0.16 FALSE
6 GTEx Artery Aorta P4HA2 0.12 0.14 lasso 2 0.11 1.2e-06 8.3 8.3 1.5e-16 0.77 0.51 0.47 FALSE
7 GTEx Artery Aorta P4HA2-AS1 0.08 0.03 lasso 3 0.01 6.6e-02 7.8 7.8 8.5e-15 0.77 0.14 0.71 FALSE
8 GTEx Artery Tibial P4HA2 0.12 0.15 lasso 6 0.14 3.2e-11 7.9 7.8 6.3e-15 0.77 0.82 0.18 FALSE
9 GTEx Artery Tibial HINT1 0.11 0.04 enet 18 0.06 1.0e-05 -4.6 -5.8 7.6e-09 -0.39 0.52 0.12 FALSE
10 GTEx Artery Tibial SLC22A5 0.18 0.12 enet 8 0.12 2.5e-09 9.1 -9.7 4.7e-22 -0.82 0.52 0.48 FALSE
11 GTEx Artery Tibial P4HA2-AS1 0.10 0.09 lasso 4 0.11 1.0e-08 7.9 7.9 3.3e-15 0.77 0.54 0.46 FALSE
12 GTEx Brain Caudate basal ganglia AC034220.3 0.41 0.45 enet 19 0.46 8.8e-15 -5.8 5.7 9.4e-09 0.67 1.00 0.00 FALSE
13 GTEx Brain Cortex AC034220.3 0.43 0.39 lasso 15 0.17 2.4e-05 -5.8 5.5 3.3e-08 0.65 0.98 0.02 FALSE
14 GTEx Brain Frontal Cortex BA9 AC034220.3 0.31 0.20 lasso 14 0.21 3.3e-06 -5.5 5.8 5.3e-09 0.70 0.46 0.44 FALSE
15 GTEx Brain Hippocampus AC034220.3 0.21 0.15 lasso 14 0.18 5.8e-05 -5.5 7.0 3.5e-12 0.73 0.32 0.40 FALSE
16 GTEx Brain Nucleus accumbens basal ganglia SLC22A5 0.15 0.00 enet 24 0.05 1.4e-02 -5.5 6.0 2.3e-09 0.55 0.10 0.22 TRUE
17 GTEx Brain Nucleus accumbens basal ganglia AC034220.3 0.24 0.24 enet 34 0.24 3.7e-07 -5.6 5.8 6.2e-09 0.66 0.87 0.07 FALSE
18 GTEx Breast Mammary Tissue SLC22A5 0.10 0.02 enet 16 0.06 4.5e-04 9.0 -5.5 4.9e-08 -0.72 0.03 0.96 FALSE
19 GTEx Cells EBV-transformed lymphocytes SLC22A5 0.37 0.05 lasso 13 0.10 2.8e-04 9.0 -7.3 2.7e-13 -0.74 0.05 0.89 FALSE
20 GTEx Cells Transformed fibroblasts PDLIM4 0.08 0.09 lasso 1 0.07 6.4e-06 -5.8 -5.8 7.0e-09 -0.52 0.84 0.02 FALSE
21 GTEx Cells Transformed fibroblasts SLC22A5 0.32 0.28 lasso 7 0.35 1.6e-27 -8.3 -9.3 1.6e-20 -0.79 1.00 0.00 FALSE
22 GTEx Colon Sigmoid AC034220.3 0.18 0.11 lasso 12 0.06 3.7e-03 -5.5 5.5 3.3e-08 0.68 0.25 0.14 FALSE
23 GTEx Colon Transverse SLC22A5 0.12 0.07 enet 8 0.07 2.5e-04 9.0 -9.9 4.1e-23 -0.77 0.12 0.79 TRUE
24 GTEx Colon Transverse AC034220.3 0.30 0.15 lasso 3 0.11 8.4e-06 -5.9 6.0 2.7e-09 0.67 0.92 0.04 FALSE
25 GTEx Esophagus Gastroesophageal Junction SEPT8 0.22 0.08 lasso 12 0.10 2.2e-04 -5.6 6.8 1.0e-11 0.63 0.40 0.41 FALSE
26 GTEx Esophagus Gastroesophageal Junction UQCRQ 0.21 0.01 enet 30 0.04 2.0e-02 -8.4 -6.6 4.5e-11 -0.42 0.08 0.21 FALSE
27 GTEx Esophagus Mucosa P4HA2 0.23 0.10 lasso 6 0.14 6.1e-10 8.3 6.8 1.3e-11 0.69 0.94 0.06 FALSE
28 GTEx Esophagus Mucosa SLC22A5 0.16 0.16 enet 8 0.16 6.3e-11 9.0 -9.3 1.5e-20 -0.82 0.95 0.05 FALSE
29 GTEx Esophagus Mucosa AC034220.3 0.08 0.03 lasso 3 0.05 4.7e-04 -5.5 5.6 2.6e-08 0.66 0.97 0.01 FALSE
30 GTEx Esophagus Mucosa P4HA2-AS1 0.09 0.06 lasso 6 0.08 5.4e-06 8.3 8.2 1.8e-16 0.77 0.43 0.55 FALSE
31 GTEx Heart Atrial Appendage AC034220.3 0.16 0.09 enet 17 0.18 1.7e-08 -5.7 6.2 6.8e-10 0.72 0.88 0.11 FALSE
32 GTEx Lung RAD50 0.12 0.09 lasso 11 0.08 1.3e-06 -5.2 -5.3 1.4e-07 -0.44 0.92 0.02 FALSE
33 GTEx Lung SLC22A5 0.10 0.15 enet 11 0.13 3.4e-10 9.0 -9.0 1.7e-19 -0.84 0.70 0.30 FALSE
34 GTEx Muscle Skeletal AC034220.3 0.27 0.23 lasso 9 0.24 9.1e-24 -5.8 6.3 2.5e-10 0.68 1.00 0.00 FALSE
35 GTEx Muscle Skeletal MIR3936 0.04 0.01 lasso 4 0.00 9.9e-02 -5.8 7.7 2.0e-14 0.69 0.20 0.21 FALSE
36 GTEx Nerve Tibial P4HA2 0.19 0.12 enet 26 0.14 6.2e-10 -5.7 5.2 2.4e-07 0.68 0.94 0.05 FALSE
37 GTEx Nerve Tibial SLC22A5 0.17 0.11 lasso 9 0.09 5.5e-07 -4.0 -6.5 6.0e-11 -0.43 0.71 0.25 FALSE
38 GTEx Nerve Tibial AC034220.3 0.15 0.11 lasso 5 0.10 1.9e-07 -5.7 5.7 1.2e-08 0.66 1.00 0.00 FALSE
39 GTEx Nerve Tibial P4HA2-AS1 0.14 0.05 lasso 8 0.08 3.8e-06 6.1 5.7 9.7e-09 0.69 0.89 0.10 FALSE
40 GTEx Ovary PDLIM4 0.25 0.22 enet 10 0.05 2.1e-02 -5.6 7.0 2.5e-12 0.55 0.35 0.21 FALSE
41 GTEx Pituitary AC034220.3 0.25 0.22 lasso 12 0.18 3.1e-05 -5.3 5.8 8.8e-09 0.63 0.70 0.04 FALSE
42 GTEx Prostate AC034220.3 0.38 0.37 lasso 5 0.37 3.0e-10 -5.9 6.7 1.8e-11 0.70 0.65 0.34 FALSE
43 GTEx Skin Not Sun Exposed Suprapubic PDLIM4 0.13 0.08 lasso 2 0.06 2.6e-04 9.0 -9.5 3.2e-21 -0.78 0.45 0.22 FALSE
44 GTEx Skin Not Sun Exposed Suprapubic SLC22A4 0.13 0.00 lasso 4 0.01 7.1e-02 -9.2 -8.6 9.5e-18 -0.70 0.14 0.14 FALSE
45 GTEx Skin Not Sun Exposed Suprapubic SLC22A5 0.13 0.05 lasso 8 0.05 8.3e-04 -5.6 -7.2 6.2e-13 -0.78 0.35 0.64 FALSE
46 GTEx Skin Sun Exposed Lower leg PDLIM4 0.09 0.08 lasso 8 0.09 1.0e-07 8.3 -9.2 2.5e-20 -0.83 0.13 0.87 FALSE
47 GTEx Skin Sun Exposed Lower leg SLC22A5 0.25 0.21 lasso 3 0.20 1.4e-16 9.1 -8.6 5.6e-18 -0.84 1.00 0.00 FALSE
48 GTEx Spleen SLC22A5 0.26 0.28 lasso 4 0.28 6.6e-08 9.0 8.3 1.2e-16 0.81 0.07 0.82 FALSE
49 GTEx Stomach SLC22A5 0.09 0.04 lasso 4 0.01 9.0e-02 -8.3 -7.3 2.0e-13 -0.71 0.14 0.21 FALSE
50 GTEx Stomach AC034220.3 0.17 0.15 enet 21 0.16 4.2e-08 -5.4 6.4 1.7e-10 0.63 1.00 0.00 FALSE
51 GTEx Testis P4HA2 0.14 0.13 lasso 5 0.11 1.4e-05 8.3 9.5 2.7e-21 0.83 0.08 0.91 FALSE
52 GTEx Testis AC034220.3 0.15 0.12 lasso 9 0.12 4.4e-06 -5.8 5.8 8.0e-09 0.66 0.89 0.01 FALSE
53 GTEx Thyroid P4HA2 0.08 0.07 enet 9 0.06 3.5e-05 7.9 8.2 3.4e-16 0.76 0.39 0.52 FALSE
54 GTEx Thyroid PDLIM4 0.05 0.02 enet 5 0.01 3.1e-02 6.1 -7.2 8.7e-13 -0.73 0.05 0.89 FALSE
55 GTEx Thyroid SLC22A5 0.17 0.07 lasso 5 0.13 4.8e-10 -4.0 -8.0 1.2e-15 -0.66 0.66 0.31 FALSE
56 GTEx Thyroid P4HA2-AS1 0.08 0.06 enet 14 0.05 1.6e-04 7.9 9.1 1.4e-19 0.77 0.24 0.68 FALSE
57 GTEx Whole Blood SLC22A4 0.07 0.05 enet 16 0.05 4.6e-05 -8.3 -9.4 3.4e-21 -0.69 0.16 0.74 FALSE
58 GTEx Whole Blood SLC22A5 0.09 0.12 lasso 2 0.10 1.7e-09 9.0 -9.0 3.0e-19 -0.84 0.84 0.16 FALSE
59 GTEx Whole Blood AC034220.3 0.08 0.05 enet 31 0.06 4.0e-06 9.3 -9.9 3.2e-23 -0.77 0.14 0.85 FALSE
60 GTEx Whole Blood AC116366.6 0.05 0.04 lasso 17 0.03 5.7e-04 -5.2 6.4 1.2e-10 0.61 0.18 0.69 FALSE
61 METSIM Adipose P4HA2 0.09 0.08 lasso 12 0.09 2.4e-13 7.9 5.9 4.2e-09 0.67 0.97 0.03 FALSE
62 METSIM Adipose PDLIM4 0.05 0.04 lasso 4 0.02 2.8e-04 6.0 -6.1 1.3e-09 -0.65 0.91 0.03 FALSE
63 METSIM Adipose SLC22A4 0.05 0.02 lasso 3 0.03 8.4e-06 7.7 -7.7 1.5e-14 -0.70 0.51 0.47 FALSE
64 METSIM Adipose SLC22A5 0.05 0.08 lasso 1 0.08 1.0e-11 9.0 -9.0 3.0e-19 -0.84 0.44 0.56 FALSE
65 NTR Blood C5orf56 0.01 0.01 blup 439 0.01 1.7e-03 -8.7 -8.3 9.6e-17 -0.49 0.23 0.16 FALSE
66 NTR Blood IRF1 0.03 0.02 blup 424 0.01 5.7e-05 -5.2 9.5 1.4e-21 0.67 0.74 0.26 FALSE
67 NTR Blood SLC22A4 0.02 0.00 blup 423 0.01 5.2e-04 7.7 -8.2 3.7e-16 -0.69 0.07 0.92 FALSE
68 NTR Blood SLC22A5 0.02 0.01 lasso 5 0.02 2.3e-06 9.8 -11.0 5.0e-28 -0.76 0.03 0.96 TRUE
69 ROSMAP Brain Pre-frontal Cortex PDLIM4 0.25 0.27 lasso 4 0.26 2.7e-33 -5.8 -6.1 8.1e-10 -0.57 1.00 0.00 FALSE
70 YFS Blood SLC22A4 0.10 0.12 enet 47 0.14 5.1e-42 -5.8 -7.7 2.0e-14 -0.78 1.00 0.00 FALSE
71 YFS Blood SLC22A5 0.38 0.36 bslmm 430 0.37 3.0e-128 9.0 -8.3 7.6e-17 -0.80 1.00 0.00 FALSE
72 The Cancer Genome Atlas Breast Invasive Carcinoma P4HA2 0.03 0.02 blup 47 0.03 3.1e-06 7.9 6.2 6.4e-10 0.65 0.04 0.95 FALSE
73 The Cancer Genome Atlas Breast Invasive Carcinoma PDLIM4 0.05 0.05 lasso 4 0.05 9.0e-11 -5.8 -6.8 1.2e-11 -0.56 1.00 0.00 TRUE
74 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A4 0.05 0.01 enet 7 0.02 1.6e-05 9.0 -6.3 2.3e-10 -0.71 0.44 0.13 FALSE
75 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A5 0.05 0.07 enet 11 0.09 5.3e-17 -5.4 -5.9 2.8e-09 -0.62 1.00 0.00 FALSE
76 The Cancer Genome Atlas Colon Adenocarcinoma PDLIM4 0.14 0.04 enet 9 0.09 6.8e-06 -6.7 -8.9 4.9e-19 -0.59 0.42 0.29 FALSE
77 The Cancer Genome Atlas Colon Adenocarcinoma SLC22A5 0.08 0.04 blup 92 0.07 1.2e-04 -8.3 -9.2 5.0e-20 -0.78 0.03 0.91 FALSE
78 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A4 0.02 0.02 lasso 1 0.02 3.0e-03 -5.6 -5.6 1.9e-08 -0.57 0.23 0.12 FALSE
79 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A5 0.06 0.05 blup 93 0.08 1.2e-09 -5.7 -7.3 2.6e-13 -0.76 0.82 0.17 FALSE
80 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDLIM4 0.09 0.02 lasso 6 0.05 4.5e-06 -5.8 -6.0 1.6e-09 -0.52 0.16 0.72 FALSE
81 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SLC22A4 0.03 0.03 lasso 1 0.02 3.5e-03 -5.6 -5.6 2.1e-08 -0.66 0.46 0.04 FALSE
82 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SLC22A5 0.06 0.04 blup 93 0.04 8.9e-06 -0.4 5.4 6.2e-08 0.42 0.50 0.26 FALSE
83 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SLC22A4 0.04 0.03 blup 108 0.01 7.1e-02 -5.4 -5.4 5.8e-08 -0.55 0.13 0.06 FALSE
84 The Cancer Genome Atlas Brain Lower Grade Glioma C5orf56 0.03 0.01 blup 98 0.02 4.2e-03 -5.1 8.4 4.8e-17 0.73 0.09 0.42 TRUE
85 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PDLIM4 0.08 0.03 blup 67 0.05 2.4e-03 -5.3 -5.8 6.5e-09 -0.54 0.04 0.38 FALSE
86 The Cancer Genome Atlas Lung Adenocarcinoma LYRM7 0.03 0.01 enet 10 0.02 7.5e-04 -4.2 5.3 1.1e-07 0.24 0.01 0.80 FALSE
87 The Cancer Genome Atlas Lung Adenocarcinoma SLC22A5 0.06 0.03 lasso 4 0.02 9.3e-04 -8.3 -8.6 1.1e-17 -0.65 0.12 0.46 FALSE
88 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A4 0.04 0.01 blup 111 0.03 3.0e-04 -3.7 -7.6 2.7e-14 -0.68 0.06 0.72 FALSE
89 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A5 0.05 0.03 blup 93 0.05 1.9e-06 -5.4 -6.3 2.6e-10 -0.69 0.65 0.33 FALSE
90 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SLC22A5 0.12 0.04 blup 92 0.07 2.2e-05 -8.3 -8.0 1.2e-15 -0.52 0.10 0.65 FALSE
91 The Cancer Genome Atlas Prostate Adenocarcinoma PDLIM4 0.32 0.36 enet 13 0.37 3.8e-40 -5.8 -6.5 7.0e-11 -0.56 1.00 0.00 FALSE
92 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A4 0.09 0.07 blup 108 0.09 3.0e-09 -5.7 -8.0 9.0e-16 -0.74 0.06 0.94 FALSE
93 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A5 0.12 0.05 lasso 4 0.08 1.8e-08 -4.6 -5.6 1.9e-08 -0.41 0.96 0.01 FALSE
94 The Cancer Genome Atlas Stomach Adenocarcinoma SLC22A5 0.05 0.01 blup 92 0.02 1.1e-02 -6.1 -6.6 4.5e-11 -0.49 0.09 0.15 FALSE
95 The Cancer Genome Atlas Thyroid Carcinoma C5orf56 0.06 0.04 blup 98 0.03 1.3e-03 -5.4 5.4 7.3e-08 0.59 0.66 0.26 FALSE
96 The Cancer Genome Atlas Thyroid Carcinoma IRF1 0.05 0.02 blup 83 0.03 1.5e-03 10.6 9.0 1.9e-19 0.87 0.00 0.90 TRUE
97 The Cancer Genome Atlas Thyroid Carcinoma P4HA2 0.21 0.35 enet 10 0.35 4.7e-35 7.9 8.4 4.8e-17 0.76 0.61 0.39 FALSE
98 The Cancer Genome Atlas Thyroid Carcinoma SLC22A5 0.03 0.02 lasso 1 0.01 2.6e-02 -8.3 -8.3 7.5e-17 -0.70 0.02 0.60 FALSE