TWAS hub - TRAF3IP2-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.566	0.0520	0	0.288	0.338	0.429	0.374	0.436	2.4e-35	1.8e-42	6.2e-57	7.3e-48	4.1e-58
2	ROSMAP	Brain Pre-frontal Cortex	0.242	0.0482	0	0.298	0.182	0.278	0.297	0.295	9.5e-39	8.9e-23	8.4e-36	1.3e-38	2.7e-38

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ulcerative Colitis (UC)	14.3	26.8	29.3	-4.9	5.4
Irritable Bowel Disease (IBD)	11.3	26.8	31.6	-4.7	5.6
Ulcerative Colitis	11.2	16.2	18.0	-3.8	4.2
Exposure to tobacco smoke at home	7.9	8.9	10.1	3.2	-2.8
Hair/balding pattern: Pattern 4	4.4	10.6	13.2	-3.6	2.9
Mean Putamen Volume	3.8	4.4	4.8	-2.2	2.0
Hearing difficulty/problems: Yes	3.8	5.8	6.5	2.3	-2.5
Ever had bowel cancer screening	3.6	4.2	4.2	2.0	-2.1
Triglycerides	3.5	5.8	9.5	1.4	-3.1
Glaucoma (self-reported)	3.5	4.1	4.3	1.9	-2.1
Tinnitus: Yes, now most or all of the time	3.4	3.9	5.6	1.5	-2.4
Bipolar Disorder (2011)	3.3	3.2	3.7	-1.6	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	4.8	2.2	-1.6
Supplements: Calcium	3.1	3.4	4.9	-1.4	2.2
Bilateral oophorectomy (both ovaries removed)	2.9	3.4	4.3	1.6	-2.1
Multivitamins +/- minerals	2.9	3.6	5.8	1.2	-2.4
Pulse rate, automated reading	2.9	9.2	10.4	2.8	-3.2
Crohns Disease (2017)	2.8	6.1	8.6	-1.9	2.9
Blood Red Count	2.8	26.9	37.8	4.0	-6.2
Crohns Disease (2012)	2.7	4.3	6.7	-1.4	2.6
Waist circumference	2.7	10.0	10.0	3.2	-3.2
Leg fat mass (right)	2.7	10.7	11.6	3.4	-3.1
Taking other prescription medications	2.6	4.0	5.8	2.4	-1.5
Birth weight	2.6	5.7	7.3	2.1	-2.7
Leg fat percentage (right)	2.6	9.3	9.4	3.1	-3.0
Had menopause	2.5	3.1	3.2	1.8	-1.7
Hip circumference	2.5	10.9	11.3	3.2	-3.4
Worrier / anxious feelings	2.5	4.8	6.5	-2.5	1.7
Knee pain experienced in last month	2.4	3.8	4.9	2.2	-1.6
Mother’s age at death	2.4	2.9	3.0	-1.7	1.7
Leg fat mass (left)	2.4	9.2	10.4	3.2	-2.8
Allergy or Eczema	2.3	6.0	6.2	-2.4	2.5
Pulse rate	2.3	3.8	4.3	1.8	-2.1
Illnesses of siblings: Diabetes	2.3	2.9	3.8	1.4	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.8	5.1	2.1	-2.3
Number of self-reported non-cancer illnesses	2.3	4.0	5.3	2.3	-1.6
Medication: Bendroflumethiazide	2.3	3.5	4.5	2.1	-1.6
Medication: Co-codamol	2.2	2.5	3.3	1.8	-1.3
Past tobacco smoking	2.2	4.0	7.1	-2.7	1.0
Whole body fat mass	2.2	9.3	9.7	3.0	-3.1
Supplements: Vitamin C	2.2	2.6	3.1	1.5	-1.8
Ever taken oral contraceptive pill	2.2	2.4	4.1	2.0	-0.9
Number of treatments/medications taken	2.1	3.7	3.8	1.9	-2.0
Supplements: Zinc	2.1	2.2	3.3	1.1	-1.8
Medication: Atenolol	2.1	2.6	2.7	1.6	-1.6
Average weekly champagne plus white wine intake	2.1	2.8	4.4	-2.1	1.1
Medication: Atorvastatin	2.1	2.6	4.0	1.1	-2.0
Lupus	2.0	3.0	3.8	-1.9	1.5
Vitamin and mineral supplements	2.0	2.7	3.8	-1.2	1.9
Hand grip strength (right)	2.0	5.5	5.7	2.4	-2.3
Hearing difficulty/problems with background noise	2.0	3.2	4.0	2.0	-1.6
Father’s age at death	2.0	2.7	2.8	-1.7	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	3.5	1.9	-1.1
Age at last live birth	2.0	3.0	4.5	-2.1	1.2
Smoking status: Previous	2.0	3.0	4.7	2.2	-1.1
Leg fat percentage (left)	2.0	7.1	7.5	2.7	-2.6
Commuting to job workplace: Cycle	2.0	2.4	3.4	-1.2	1.9
Mouth/teeth dental problems: Dentures	1.9	3.3	4.8	2.2	-1.3
Arm fat mass (left)	1.9	7.7	8.2	2.7	-2.9
Wears glasses or contact lenses	1.9	2.2	3.3	1.8	-1.0
Weight	1.8	8.9	10.2	3.2	-2.8
Body fat percentage	1.8	7.3	8.2	2.5	-2.9
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	3.0	-1.2	1.7
Mineral and other dietary supplements	1.8	2.4	2.9	-1.7	1.4
Financial situation satisfaction	1.8	2.3	2.5	-1.6	1.4
Supplements: Fish oil (including cod liver oil)	1.8	2.3	3.5	1.9	-1.1
Lung cancer (father)	1.7	2.0	3.9	0.2	-2.0
Illnesses of father: High blood pressure	1.7	2.1	3.2	1.0	-1.8
Trunk fat percentage	1.6	6.5	7.6	2.3	-2.8
Trunk fat mass	1.6	7.0	7.2	2.6	-2.7
Medication: Ramipril	1.6	2.0	2.0	1.4	-1.4
Noisy workplace	1.6	1.9	2.3	1.2	-1.5
Arm fat mass (right)	1.6	6.7	6.8	2.6	-2.6
Loneliness, isolation	1.6	2.2	3.4	-1.8	1.0
HbA1C	1.5	1.7	2.8	0.8	-1.7
Lung FVC	1.5	7.6	9.0	-3.0	2.5
Pulse wave Arterial Stiffness index	1.5	1.8	3.4	1.8	-0.3
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	3.7	-1.1	1.9
Leg predicted mass (left)	1.4	7.2	8.4	2.9	-2.5
Medication: Lansoprazole	1.4	1.5	2.2	1.5	-0.9
Exposure to tobacco smoke outside home	1.4	1.8	3.5	1.9	-0.3
Arm fat-free mass (left)	1.4	7.2	9.6	3.1	-2.2
Risk taking	1.4	2.1	3.1	1.8	-1.1
Arm predicted mass (left)	1.4	7.0	9.4	3.1	-2.1
Smoking Status	1.3	3.1	6.1	2.5	-0.5
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.8	1.7	-0.7
Leg fat-free mass (left)	1.3	7.1	8.3	2.9	-2.4
Breastfed as a baby	1.3	1.6	3.2	1.8	-0.3
Pulse wave peak to peak time	1.3	1.5	2.9	-1.7	0.3
Arm fat percentage (left)	1.3	5.2	6.4	2.0	-2.5
Average weekly beer plus cider intake	1.3	1.9	3.1	-0.9	1.7
Worry (Nagel 2018)	1.2	2.6	4.1	-2.0	1.0
Reaction Time	1.2	2.4	3.8	-1.9	1.0
Qualifications: CSEs or equivalent	1.2	1.6	2.4	-0.9	1.5
Body mass index (BMI)	1.2	5.1	5.4	2.3	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	6.6	-2.6	1.1
Medication: Blood pressure	1.2	2.0	2.8	1.1	-1.7
Basal metabolic rate	1.2	6.7	8.5	2.9	-2.2
Pain experienced in last month	1.2	1.9	2.2	-1.3	1.5
Basal cell carcinoma (self-reported)	1.2	1.4	1.9	1.4	-0.9
Height	1.1	21.0	27.2	5.2	-3.9
Hand grip strength (left)	1.1	2.9	3.8	1.9	-1.5
Diabetes (father)	1.1	1.3	1.5	1.1	-1.2
Hayfever, allergic rhinitis or eczema	1.1	2.4	2.8	-1.4	1.7
Arm fat percentage (right)	1.1	4.4	5.1	1.9	-2.3
Arm fat-free mass (right)	1.1	5.8	7.7	2.8	-2.0
Leg predicted mass (right)	1.1	5.9	7.2	2.7	-2.1
Ever smoked	1.1	1.9	3.6	1.9	-0.5
Age started oral contraceptive pill	1.1	1.4	2.2	0.8	-1.5
Bipolar Disorder (2018)	1.0	1.6	2.9	-0.6	1.7
Chronic bronchitis/emphysema (father)	1.0	1.2	1.3	1.1	-1.1
Blood clot in the leg (DVT)	1.0	1.3	1.6	-1.3	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	1.4	1.1	-1.2
Migraine (self-reported)	1.0	1.3	1.7	0.9	-1.3
Leg fat-free mass (right)	1.0	5.5	6.7	2.6	-2.1
Breast cancer (self-reported)	1.0	1.2	1.3	-1.2	1.0
Hearing aid user	1.0	1.2	1.3	1.1	-1.0
Bipolar Disorder or Schizophrenia	0.9	2.3	4.5	0.3	2.1
Alzheimer’s Disease (in mother)	0.9	1.1	1.7	0.7	-1.3
Breast Cancer	0.9	2.1	3.8	-2.0	0.5
Hypothyroidism (self reported)	0.9	2.1	3.7	0.6	-1.9
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	5.9	-2.4	0.7
Arm predicted mass (right)	0.9	4.7	6.6	2.6	-1.7
Hypertension (Self-reported)	0.9	2.4	3.8	1.0	-2.0
Whole body fat-free mass	0.9	5.1	7.1	2.7	-1.8
Whole body water mass	0.9	5.0	6.9	2.6	-1.8
Medication: Blood pressure	0.9	1.6	1.7	1.2	-1.3
Townsend deprivation index at recruitment	0.8	1.2	1.6	-0.8	1.3
High blood pressure	0.8	2.2	3.2	1.1	-1.8
Allergy	0.8	1.8	1.8	1.3	-1.4
Alcohol intake versus 10 years previously	0.8	1.1	1.4	1.2	-1.0
High blood pressure (siblings)	0.8	1.2	1.6	0.8	-1.3
Illnesses of father: None of the above (group 1)	0.8	1.0	1.9	-0.3	1.4
Eye problems/disorders: Glaucoma	0.8	1.0	1.1	1.1	-0.9
Unable to work because of sickness or disability	0.8	1.0	1.9	0.3	1.4
Fasting Glucose	0.7	0.8	1.2	-1.1	0.6
Blood White Count	0.7	5.1	6.8	1.9	-2.6
Systolic blood pressure, automated reading	0.7	2.0	2.2	1.3	-1.5
Maternal smoking around birth	0.7	1.0	1.1	0.9	-1.0
Sitting height	0.7	5.2	6.2	2.5	-2.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	1.5	-0.9	1.2
Headache pain in last month	0.7	1.2	1.3	1.0	-1.1
Forced vital capacity (FVC), Best measure	0.7	2.6	4.3	-2.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	0.2	-1.3
Medication: Aspirin	0.7	0.9	1.2	0.8	-1.1
Illnesses of father: Heart disease	0.7	1.0	1.7	0.6	-1.3
Long-standing illness, disability or infirmity	0.7	1.0	2.1	1.4	0.0
Guilty feelings	0.7	1.0	1.1	-1.1	0.9
Neuroticism (Nagel 2018)	0.6	1.5	2.4	-1.6	0.7
Schizophrenia (2018)	0.6	1.3	1.9	0.8	1.4
Neuroticism (2016)	0.6	0.9	1.2	-1.1	0.8
Schizophrenia (2014)	0.6	1.2	2.3	0.4	1.5
Average weekly spirits intake	0.6	0.7	1.0	-1.0	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.6	-0.9	1.3
Had other major operations	0.6	0.8	1.2	1.1	0.6
Forced vital capacity (FVC)	0.6	2.2	3.8	-1.9	0.8
Illnesses of siblings	0.6	0.8	1.5	-0.4	1.2
Trunk fat-free mass	0.6	3.4	5.4	2.3	-1.2
Number of live births	0.6	0.8	1.0	-0.8	1.0
Trunk predicted mass	0.6	3.3	5.3	2.3	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.0	1.0	-1.0
Gout (self-reported)	0.6	0.8	1.1	-1.1	0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	1.9	0.7	-1.4
Number of full brothers	0.6	0.8	1.2	0.6	-1.1
Medication: Ibuprofen	0.6	0.8	0.8	0.9	-0.9
Back pain experienced in last month	0.6	0.9	1.6	0.4	-1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.0	0.7	-1.0
Diastolic blood pressure, automated reading	0.6	2.0	3.6	0.6	-1.9
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.3	-1.0	1.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.1	-1.0	0.8
Sensitivity / hurt feelings	0.5	0.8	1.5	-1.2	0.2
Supplements: Glucosamine	0.5	0.6	0.9	0.6	-0.9
Financial difficulties in last 2 years	0.5	0.6	0.9	0.6	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.3	1.1	-0.3
Asthma	0.5	1.0	1.1	1.0	-1.1
Wheeze or whistling in the chest in last year	0.5	0.8	1.7	1.3	-0.1
Age at first live birth	0.5	0.9	1.6	-1.2	0.4
Eye problems/disorders: None of the above	0.5	0.6	0.7	-0.8	0.8
Medication: Omeprazole	0.5	0.6	1.0	1.0	-0.4
Alcohol intake frequency.	0.5	1.2	1.7	-0.8	1.3
Leg pain on walking	0.5	0.6	1.0	1.0	-0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	0.6	-0.7	0.8
Irritability	0.5	0.8	0.9	1.0	-0.9
Cholesterol lowering medication	0.5	0.7	1.0	0.7	-1.0
Heart disease (siblings)	0.5	0.6	1.3	0.0	-1.1
Coronary Artery Disease (CAD)	0.4	0.4	0.7	-0.8	0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.7	-0.6	0.8
BMI	0.4	2.1	3.3	1.0	-1.8
Lung FEV1/FVC ratio	0.4	2.0	4.1	0.0	-2.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	0.9	-0.3
Diabetes (mother)	0.4	0.5	1.1	-1.0	0.2
Severe depression (siblings)	0.4	0.4	0.8	0.9	0.2
Pack years adult smoking proportion	0.4	0.6	1.0	-0.3	1.0
Age when periods started (menarche)	0.4	0.9	1.8	1.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.9	-1.0	0.4
Mouth/teeth dental problems	0.4	0.6	1.0	-1.0	0.5
Fluid intelligence score	0.4	0.9	1.7	0.3	-1.3
Prospective memory result	0.4	0.5	0.9	1.0	-0.2
Standing height	0.4	3.6	4.6	2.1	-1.6
Length of working week for main job	0.4	0.4	0.8	0.9	0.2
Pulse wave reflection index	0.4	0.4	0.7	-0.4	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.6	0.8	-0.5
Emphysema/chronic bronchitis	0.4	0.4	0.9	0.0	0.9
Family relationship satisfaction	0.4	0.5	0.7	0.5	-0.8
Friendships satisfaction	0.4	0.4	0.6	0.5	-0.8
Eye problems/disorders: Cataract	0.4	0.5	0.5	-0.7	0.7
Asthma (self-reported)	0.4	0.8	0.9	0.8	-1.0
Osteoporosis (self-reported)	0.4	0.5	0.9	1.0	0.1
Smoking status: Current	0.4	0.6	0.9	0.5	0.9
High cholesterol (Self-reported)	0.4	0.6	1.0	0.5	-1.0
Fractured/broken bones in last 5 years	0.4	0.5	1.0	1.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	1.0	-0.3
Alcohol drinker status: Previous	0.4	0.5	0.8	0.9	0.3
Alzheimer’s Disease (in father)	0.3	0.3	0.4	-0.5	0.6
Age at First Birth	0.3	0.4	0.7	-0.9	0.3
Primary Biliary Cirrhosis	0.3	0.5	0.8	-0.9	0.3
Neuroticism	0.3	0.7	1.0	-1.0	0.6
Hair Pigment	0.3	8.3	11.2	-3.3	2.3
Angina	0.3	0.4	0.6	0.5	-0.8
Medication for hormone replacement therapy	0.3	0.3	0.5	-0.3	0.7
Current tobacco smoking	0.3	0.5	1.0	1.0	0.2
Average weekly fortified wine intake	0.3	0.4	0.6	0.8	-0.4
Serious illness, injury or assault to yourself	0.3	0.4	0.7	0.8	-0.4
Medication: Levothyroxine sodium	0.3	0.5	0.7	0.4	-0.9
Hair/balding pattern: Pattern 2	0.3	0.4	0.6	-0.4	0.8
Pain all over the body in last month	0.3	0.3	0.6	0.8	0.1
Falls in the last year	0.3	0.3	0.7	0.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	0.6	-0.7
Peak expiratory flow (PEF)	0.3	0.7	1.3	-1.1	0.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	-0.8	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.8	-0.1
Shortness of breath walking on level ground	0.3	0.4	0.8	0.9	-0.2
Qualifications: College or University degree	0.3	0.9	1.4	0.6	-1.2
Medication for pain relief, constipation, heartburn	0.3	0.6	0.6	-0.7	0.8
Mean time to correctly identify matches	0.3	0.5	1.0	-1.0	0.3
Suffer from ‘nerves’	0.3	0.5	0.7	-0.9	0.4
Had major operations	0.3	0.3	0.6	0.2	0.8
Mood swings	0.3	0.6	0.6	0.8	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.4	0.5	-0.6
Medication: Lisinopril	0.3	0.3	0.4	0.6	-0.5
Number of operations (self-reported)	0.3	0.5	0.7	0.8	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	0.8	0.4	-0.9
Major Depression (MDD)	0.2	0.3	0.4	0.6	-0.4
Ovarian Cancer	0.2	0.3	0.4	-0.4	-0.6
HDL Cholesterol	0.2	0.4	0.6	0.5	0.8
Cardiovascular Disease	0.2	0.8	1.6	-0.3	-1.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.6	0.4
Relative age voice broke	0.2	0.3	0.5	0.7	-0.1
High blood pressure (mother)	0.2	0.3	0.6	-0.8	0.3
Impedance of leg (left)	0.2	0.8	1.3	-1.1	0.6
Nervous feelings	0.2	0.4	0.5	-0.7	-0.5
Diabetes (self-reported)	0.2	0.3	0.3	0.5	-0.5
Medication: Simvastatin	0.2	0.3	0.4	-0.6	0.5
Impedance of arm (right)	0.2	0.7	1.5	-1.2	0.0
Happiness	0.2	0.3	0.6	0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.5	-0.7	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.2	-0.6
Medication: Cholesterol lowering	0.2	0.3	0.5	0.1	-0.7
Depression (self-reported)	0.2	0.2	0.3	0.6	-0.2
Illnesses of mother	0.2	0.2	0.3	0.6	0.3
Birth weight of first child	0.2	0.4	0.5	0.5	-0.7
Loud music exposure frequency	0.2	0.2	0.2	-0.4	0.5
Worry too long after embarrassment	0.2	0.4	0.8	-0.9	-0.2
Neck or shoulder pain in last month	0.2	0.3	0.5	0.3	-0.7
Angina (self-reported)	0.2	0.3	0.5	0.3	-0.7
Medication: Allopurinol	0.2	0.3	0.5	-0.7	0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.6	0.4
Number of full sisters	0.2	0.2	0.4	0.3	0.6
Chest pain or discomfort	0.2	0.2	0.5	0.1	0.7
Average weekly red wine intake	0.2	0.2	0.4	0.2	-0.6
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.7	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.5	-0.5	0.7
Medication for cholesterol	0.2	0.3	0.6	-0.2	0.8
Medication: Aspirin	0.2	0.3	0.5	0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	-0.6	0.2
Pack years of smoking	0.2	0.2	0.5	0.1	0.7
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.2	-0.4
Rheumatoid Arthritis	0.1	0.1	0.2	0.2	-0.4
Blood Eosinophil Count	0.1	0.7	1.3	0.3	-1.1
Blood Platelet Count	0.1	1.0	1.8	1.3	-0.3
Systolic Blood Pressure	0.1	0.6	1.0	0.5	-1.0
Respiratory disease	0.1	0.3	0.4	0.6	-0.4
Chronotype (morning person)	0.1	0.3	0.6	-0.8	-0.1
Tanning	0.1	1.1	1.8	1.4	-0.6
Ever had hysterectomy (womb removed)	0.1	0.2	0.3	0.5	-0.2
Medication: Metformin	0.1	0.2	0.3	0.5	-0.3
Impedance of leg (right)	0.1	0.3	0.6	-0.8	0.0
Fed-up feelings	0.1	0.2	0.3	0.1	0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.4	0.4
Stomach or abdominal pain in last month	0.1	0.2	0.3	0.2	0.5
Number of incorrect matches in round	0.1	0.1	0.2	-0.2	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	-0.2	0.5
Heart attack	0.1	0.1	0.2	-0.5	0.1
Neuroticism score	0.1	0.2	0.3	-0.6	0.2
Time employed in main current job	0.1	0.1	0.2	0.3	0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	-0.4	0.5
Impedance of arm (left)	0.1	0.7	1.1	-1.1	-0.5
Tense / ‘highly strung’	0.1	0.1	0.2	0.1	-0.4
Medication: Amlodipine	0.1	0.1	0.2	-0.3	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.2	0.4
Number of children fathered	0.1	0.1	0.1	0.3	-0.2
Health satisfaction	0.1	0.2	0.2	-0.5	0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.0	-0.4
Comparative height size at age 10	0.1	0.3	0.7	0.1	-0.8
Overall health rating	0.1	0.1	0.2	0.3	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.4	0.2
Diabetes diagnosed by doctor	0.1	0.1	0.1	0.2	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.5	-0.0
Osteoarthritis (self-reported)	0.1	0.2	0.3	-0.1	0.6
Medication: Paracetamol	0.1	0.1	0.2	0.4	-0.3
Ever depressed for a whole week	0.1	0.1	0.2	-0.2	0.5
Impedance of whole body	0.1	0.6	1.2	-1.1	-0.1
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	0.0	-0.2
Depression (Nagel 2018)	0.0	0.0	0.1	0.1	-0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.1	0.1
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	-0.1	-0.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	-0.1	-0.3
LDL Cholesterol	0.0	0.1	0.2	-0.4	-0.0
Heel T-Score	0.0	0.1	0.3	-0.5	-0.2
Waist Hip Ratio (WHR)	0.0	0.1	0.2	-0.4	0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	-0.3	0.0
Relative age of first facial hair	0.0	0.0	0.1	0.2	-0.2
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	0.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.1	-0.2
Alcohol usually taken with meals	0.0	0.0	0.1	-0.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.1	-0.3	-0.1
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.0	0.1	-0.1
Qualifications: None of the above	0.0	0.0	0.0	0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	-0.1	-0.1
Medication: Paracetamol	0.0	0.0	0.1	-0.1	-0.2
Comparative body size at age 10	0.0	0.1	0.2	-0.5	-0.1
Heart disease (mother)	0.0	0.0	0.1	-0.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	-0.2	0.2
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.1	0.0
Medication: Gliclazide	0.0	0.0	0.1	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.0	-0.1	0.2
Miserableness	0.0	0.0	0.1	-0.3	0.0
Commuting to job workplace: Public transport	0.0	0.0	0.0	-0.1	0.1
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	0.2
Myopia	0.0	0.0	0.0	0.2	-0.2

Hub : Genes

TRAF3IP2-AS1

Models

Trait associations