Hub : Genes

TRAF3IP2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1120	0.0336	7.4e-06	0.064	NA	0.097	NA	0.073	9.2e-06	NA	4.8e-08	NA	2.4e-06
2	GTEx	Nerve Tibial	0.1262	0.0527	1.6e-03	0.001	NA	-0.002	NA	0.005	2.9e-01	NA	5.3e-01	NA	1.3e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0693	0.0271	8.7e-05	0.012	0.022	0.030	0.024	0.026	9.8e-03	7.3e-04	9.0e-05	0.00042	2.3e-04
4	TCGA	Brain Lower Grade Glioma	0.0694	0.0306	5.4e-05	0.052	0.039	0.031	NA	0.045	1.5e-06	2.6e-05	1.8e-04	NA	7.4e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.8	4.4	8.6	2.9	-0.1	1.4	-2.7
Bipolar Disorder or Schizophrenia	5.5	13.4	26.1	5.1	1.5	2.0	-4.6
Depressed Affect (Nagel 2018)	0.2	0.3	0.6	-0.3	-0.7	0.4	0.8
Depression (Nagel 2018)	0.2	0.3	1.1	-0.1	0.4	-0.2	1.1
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.1	-1.1	-0.3	-0.0	1.0
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.1	-0.0	0.2	-0.5
Schizophrenia (2018)	4.6	9.5	17.8	4.2	1.9	1.4	-3.8
Schizophrenia vs Biploar Disorder	0.7	1.0	2.1	1.5	0.2	0.6	-1.2
Worry (Nagel 2018)	0.2	0.5	0.8	0.7	0.9	0.2	-0.8
Alzheimer’s Disease (in mother)	2.2	2.6	8.2	1.4	0.1	-0.5	-2.9
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.6	-0.5	0.4	-0.1
Alzheimer’s Disease (including proxy)	1.3	1.9	4.8	1.6	0.1	0.1	-2.2
Crohns Disease (2017)	0.8	1.8	4.7	1.4	-0.2	2.2	0.6
Irritable Bowel Disease (IBD)	2.9	6.9	21.3	1.2	-2.0	4.6	0.8
Ulcerative Colitis (UC)	4.3	8.0	23.2	0.6	-2.9	4.8	0.4
Major Depression (MDD)	0.5	0.6	1.1	-0.3	-0.9	0.5	-1.1
Reaction Time	1.1	2.0	5.3	-2.3	-0.7	0.1	1.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.9	-0.7	-1.4	0.5	0.2
Breast Cancer	1.1	2.7	6.4	-2.5	-0.3	0.0	2.1
Ovarian Cancer	0.2	0.2	0.4	-0.7	0.6	-0.0	0.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.7	2.6	-0.3	-1.6	0.0	-0.6
Bipolar Disorder (2011)	0.9	0.9	2.5	0.7	-0.8	1.6	0.1
Body Mass Index (BMI) (2010)	0.7	1.0	2.0	1.4	1.3	-0.3	-0.6
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.1	-0.8	1.1	0.1
Crohns Disease (2012)	0.8	1.3	4.3	0.9	-0.4	2.1	0.1
Mean Putamen Volume	2.0	2.2	2.8	-1.7	-1.5	1.4	1.4
Fasting Glucose	0.8	1.0	2.7	-0.8	-0.7	-0.2	1.6
HbA1C	0.8	0.8	1.3	-0.9	-1.1	0.4	1.0
HDL Cholesterol	0.8	1.3	2.8	1.2	1.7	0.9	-0.5
LDL Cholesterol	0.4	0.6	1.3	-1.1	-0.1	0.3	1.1
Lupus	0.3	0.5	0.9	-0.6	-0.9	0.1	0.9
Neuroticism (2016)	0.9	1.3	1.9	1.3	1.4	0.0	-1.3
Primary Biliary Cirrhosis	1.6	2.3	5.9	-1.2	-2.4	1.1	0.8
Rheumatoid Arthritis	0.9	1.2	2.6	1.1	0.8	-0.6	-1.6
Schizophrenia (2014)	4.8	10.5	19.9	4.5	1.2	1.4	-4.3
Triglycerides	0.7	1.1	2.4	-1.0	-1.5	-0.7	0.8
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.0	-0.4	-1.7	2.0	1.7
Ulcerative Colitis	2.7	3.9	11.5	-0.2	-1.5	3.4	1.3
Blood Eosinophil Count	0.0	0.2	0.4	-0.0	-0.6	-0.1	0.6
Blood Platelet Count	0.1	0.6	2.0	1.4	-0.2	0.3	-0.5
Blood Red Count	1.6	15.1	37.2	1.1	-0.1	-6.1	-4.7
Blood White Count	0.2	1.3	2.1	0.8	-1.5	-1.4	-0.6
Heel T-Score	0.8	6.4	14.4	-2.8	-1.8	0.2	3.8
BMI	1.2	7.0	15.1	-3.4	-0.1	-0.9	3.9
Height	0.9	17.8	26.4	4.5	4.8	-1.2	-5.1
Waist Hip Ratio (WHR)	0.2	1.0	1.7	-0.5	1.3	-1.1	-1.0
Systolic Blood Pressure	0.4	1.9	5.3	-0.1	1.1	-2.3	-1.0
Smoking Status	3.0	7.2	17.4	-1.6	-1.2	2.7	4.2
Allergy or Eczema	1.0	2.5	4.6	-2.1	-0.4	1.0	2.1
Cardiovascular Disease	1.5	4.8	10.5	-3.2	-0.6	-1.6	2.4
Hypothyroidism (self reported)	1.2	2.7	3.9	-1.9	-2.0	-1.8	-0.2
Respiratory disease	0.2	0.5	1.9	0.2	1.4	0.5	0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.0	2.1	-1.4	-1.0	-0.1	1.0
Lung FEV1/FVC ratio	1.0	5.1	16.8	-1.9	-0.0	-4.1	-0.2
Lung FVC	0.1	0.7	1.5	-1.2	-0.3	-0.4	1.0
Neuroticism	0.1	0.3	1.0	0.1	1.0	-0.2	-0.2
Chronotype (morning person)	1.6	3.7	12.1	0.9	0.6	-1.2	-3.5
Hair Pigment	0.1	2.3	4.5	-2.1	-0.1	0.8	2.0
Tanning	0.5	6.3	11.4	3.3	1.4	-1.1	-3.4
Hand grip strength (left)	1.4	3.6	4.9	1.0	2.2	-1.9	-2.2
Number of treatments/medications taken	0.6	1.1	2.5	-0.1	1.6	-1.1	0.8
Average weekly spirits intake	1.0	1.2	2.9	0.4	1.7	-0.0	1.3
Sensitivity / hurt feelings	0.5	0.8	1.7	-1.3	-0.9	-0.7	0.4
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.2	-0.8	1.5	-0.4	0.8
Hearing difficulty/problems: Yes	0.5	0.8	3.0	-0.2	0.3	-1.7	-0.2
Relative age of first facial hair	0.1	0.2	0.7	-0.4	0.1	-0.1	-0.9
Other serious medical condition/disability diagnosed by doctor	2.5	3.3	6.9	2.6	1.8	0.2	-1.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	0.4	-0.0	0.8	0.8
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	0.7	0.5	1.1	0.6
Systolic blood pressure, automated reading	0.2	0.6	1.2	-0.3	1.1	-0.9	-0.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	4.3	0.6	2.1	-0.1	-0.8
Angina	0.3	0.5	0.7	-0.9	0.6	-0.4	0.7
Medication for hormone replacement therapy	4.2	4.7	7.7	-0.6	-2.6	2.1	2.8
Vitamin and mineral supplements	0.2	0.3	1.0	-0.1	-0.4	1.0	0.2
Supplements: Zinc	0.3	0.3	1.0	0.1	-0.4	-1.0	-0.2
Medication: Co-codamol	0.2	0.2	0.4	0.6	0.3	-0.7	0.1
Medication: Metformin	0.2	0.3	0.9	-0.1	-0.9	0.5	0.2
Diabetes (father)	1.2	1.4	4.8	-0.3	-2.2	0.3	0.9
Diabetes (mother)	0.0	0.1	0.1	-0.3	-0.3	-0.0	0.3
Severe depression (siblings)	0.9	1.1	3.0	1.1	1.7	0.3	0.0
Pack years adult smoking proportion	0.3	0.5	1.5	-1.2	-0.2	0.3	0.7
Impedance of leg (right)	0.1	0.6	0.8	0.9	0.9	-0.4	-0.8
Leg fat-free mass (left)	0.1	0.4	1.0	0.2	1.0	-0.7	0.1
Trunk fat percentage	2.4	9.5	24.5	-3.6	-0.4	-0.5	5.0
Hand grip strength (right)	1.6	4.5	7.5	1.4	2.1	-2.7	-2.0
Townsend deprivation index at recruitment	0.7	0.9	1.9	-1.1	-0.0	0.7	1.4
Current tobacco smoking	2.5	4.0	7.1	-1.1	-1.4	2.5	2.7
Average weekly fortified wine intake	0.4	0.4	1.4	0.4	0.2	-0.3	-1.2
Maternal smoking around birth	2.8	4.1	10.6	-1.6	-1.3	1.2	3.3
Fed-up feelings	0.4	0.7	1.5	-0.0	-1.2	1.1	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	1.2	-0.0	0.1	-0.4	1.1
Relative age voice broke	1.1	1.7	5.0	0.7	1.2	-0.0	-2.2
Taking other prescription medications	0.7	1.1	3.8	0.3	1.9	-0.1	0.8
Age when periods started (menarche)	1.3	3.2	7.4	2.7	0.3	1.8	-1.5
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.7	0.6	-0.8	0.0	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.8	4.5	-2.0	-2.1	0.4	1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.2	1.0	0.1	1.1	-0.6
Qualifications: CSEs or equivalent	0.5	0.7	2.0	0.5	1.4	-0.2	0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.2	1.1	0.7	-0.0	0.5
High blood pressure	0.8	2.1	4.8	-2.2	-0.6	-0.9	1.5
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.3	-1.4	-0.2	0.4	1.5
Multivitamins +/- minerals	1.9	2.4	7.7	-1.2	0.7	-2.8	-0.1
Stomach or abdominal pain in last month	0.2	0.2	0.7	0.8	0.1	0.2	-0.4
Supplements: Glucosamine	0.7	0.9	2.0	1.4	-0.2	-0.3	-1.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.3	-1.2	-1.8	-0.9	-0.0
Medication: Atenolol	0.4	0.5	0.8	0.0	0.9	-0.5	-0.9
Medication: Levothyroxine sodium	0.6	1.0	1.7	-1.3	-0.9	-1.3	-0.1
Sitting height	0.3	1.9	4.0	0.5	1.7	-2.0	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.8	-0.4	0.1	-0.1
High blood pressure (mother)	0.3	0.5	1.0	-0.6	1.0	-0.7	0.2
Body mass index (BMI)	1.0	4.4	12.9	-2.1	0.2	-0.2	3.6
Impedance of leg (left)	0.1	0.4	0.7	0.8	0.9	0.1	-0.5
Leg predicted mass (left)	0.1	0.4	0.9	0.2	1.0	-0.7	0.1
Trunk fat mass	1.3	5.7	15.4	-2.6	0.5	-0.5	3.9
Waist circumference	0.5	1.9	3.3	-0.8	1.8	-1.3	1.4
Number of incorrect matches in round	1.0	1.6	3.9	1.1	-1.1	0.3	-2.0
Past tobacco smoking	3.7	6.9	13.4	0.5	1.3	-3.5	-3.7
Alcohol usually taken with meals	0.1	0.2	0.7	-0.8	-0.2	-0.4	0.2
Nervous feelings	0.6	1.1	3.7	-0.1	0.4	-1.9	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.2	-0.1	0.2	-1.1	0.4
Hearing difficulty/problems with background noise	0.5	0.9	1.4	1.2	1.0	-0.7	-0.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.3	-0.2	1.2	-0.6	0.2
Had menopause	0.8	1.0	2.1	-1.5	0.4	-0.2	1.3
Had other major operations	1.5	1.9	4.0	1.7	-0.6	2.0	0.4
Forced vital capacity (FVC)	0.4	1.7	3.6	-0.4	1.8	-1.9	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	3.3	-1.8	-1.8	0.4	1.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.2	-1.5	-1.0	-0.5	1.1
Qualifications: None of the above	0.2	0.5	1.0	-0.4	0.8	0.6	1.0
Financial difficulties in last 2 years	0.6	0.8	1.5	0.6	1.2	1.2	0.0
Mouth/teeth dental problems	0.6	0.9	1.9	-0.6	-1.4	0.8	-0.9
Heart attack	0.1	0.2	0.3	-0.3	0.3	-0.6	0.3
Allergy	1.0	2.3	4.5	2.0	-0.4	-0.7	-2.1
Pain all over the body in last month	2.6	2.8	5.0	2.2	1.1	1.4	-1.8
Diabetes (self-reported)	0.1	0.2	0.3	-0.6	-0.1	-0.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.4	0.2	1.2	0.0	-0.2
Medication: Ramipril	0.2	0.3	0.8	-0.5	0.2	-0.1	0.9
Medication: Simvastatin	0.3	0.5	1.7	-0.1	1.3	0.4	-0.0
Fluid intelligence score	0.8	1.7	3.7	-1.4	-1.9	-0.9	0.3
Illnesses of siblings	0.3	0.5	1.2	0.8	-0.1	1.1	-0.1
Neuroticism score	0.0	0.1	0.2	0.1	0.2	-0.4	-0.0
Weight	0.4	1.8	3.6	-0.8	1.6	-0.6	1.9
Impedance of arm (right)	0.5	2.3	4.4	-2.1	-1.7	-0.8	1.2
Arm fat percentage (right)	2.4	9.3	24.1	-3.5	-0.7	-0.3	4.9
Trunk fat-free mass	1.0	5.5	8.8	2.7	3.0	-0.3	-2.4
Hip circumference	0.4	1.7	2.5	-0.4	1.6	-1.5	1.4
Time employed in main current job	2.1	2.5	5.1	2.2	0.7	0.9	-1.9
Alcohol intake versus 10 years previously	0.3	0.4	1.5	-0.0	-0.4	-1.2	-0.3
Father’s age at death	0.3	0.4	0.9	0.6	1.0	0.6	-0.3
Worrier / anxious feelings	0.5	1.0	2.3	0.3	1.2	-0.4	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.7	-0.6	0.6	0.2	1.7
Falls in the last year	1.3	1.7	3.5	1.6	1.9	-0.1	-1.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	-0.0	0.7	0.7	-0.3
Number of live births	0.9	1.2	4.8	0.0	2.2	0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	6.2	-1.2	1.7	-2.5	0.1
Pulse rate	0.6	1.0	2.4	0.6	-1.0	-1.6	-0.6
Happiness	0.6	0.7	1.9	-0.9	-1.4	-0.3	-0.0
Noisy workplace	1.4	1.7	2.4	0.3	1.6	-1.4	-1.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.4	-0.6	-0.7	-0.7	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	4.5	-1.4	0.5	-2.1	0.7
Mouth/teeth dental problems: Dentures	0.7	1.2	1.4	1.2	1.2	0.9	1.1
Asthma	0.7	1.3	2.0	-1.2	1.4	-0.5	1.2
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	5.1	1.4	2.3	0.4	-0.8
Medication: Cholesterol lowering	0.9	1.4	2.4	-1.5	0.7	-1.1	1.2
Depression (self-reported)	0.3	0.4	0.9	-0.0	0.7	0.2	0.9
Medication: Lansoprazole	0.4	0.4	1.5	0.1	0.1	0.5	1.2
Prospective memory result	2.1	2.6	3.5	1.8	1.9	-0.1	-1.9
Lung cancer (father)	5.0	5.9	12.6	-3.1	-1.2	-0.2	3.6
Illnesses of mother	0.2	0.2	0.8	-0.0	-0.3	-0.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.7	-1.0	1.8	-1.9	0.2
Pulse wave Arterial Stiffness index	2.0	2.3	4.3	2.1	-1.1	1.6	-1.0
Impedance of arm (left)	0.5	2.4	5.2	-2.3	-1.5	-1.1	1.0
Arm fat mass (right)	1.3	5.4	14.9	-2.5	0.4	-0.4	3.9
Trunk predicted mass	1.0	5.5	9.0	2.7	3.0	-0.3	-2.4
Standing height	0.7	7.0	11.1	2.5	3.1	-1.1	-3.3
Length of working week for main job	1.1	1.2	2.1	1.4	-0.8	0.2	-1.4
Exposure to tobacco smoke at home	1.1	1.2	2.8	1.7	1.0	0.1	-1.0
Breastfed as a baby	2.2	2.7	6.7	2.6	0.7	0.7	-1.7
Tense / ‘highly strung’	0.7	1.2	2.0	1.4	1.0	-0.2	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.0	0.7	0.7	-0.2
Hair/balding pattern: Pattern 4	2.7	6.6	13.3	-3.1	1.6	1.1	3.6
Birth weight of first child	0.3	0.5	1.3	0.4	-0.4	-1.1	-0.7
Peak expiratory flow (PEF)	1.5	3.4	8.7	-3.0	0.2	-1.5	1.6
Pulse wave reflection index	1.5	1.8	5.9	0.5	-0.9	2.4	0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	-0.4	-0.5	0.1	0.7
Loud music exposure frequency	0.2	0.2	0.4	0.6	0.2	0.2	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	0.4	-0.0	0.3	-1.0
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.1	0.7	1.0	-1.0	0.8
Blood clot in the leg (DVT)	0.6	0.8	1.6	-1.3	0.8	0.8	0.6
Medication: Paracetamol	0.5	0.9	2.0	-0.4	1.4	-1.1	0.6
Headache pain in last month	0.4	0.7	1.3	-0.0	0.7	-1.1	1.1
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.3	1.7	0.4	1.8	-1.0
Glaucoma (self-reported)	1.4	1.7	5.0	0.2	0.7	-2.2	-1.1
Gout (self-reported)	1.9	2.6	5.6	-2.1	-0.4	-0.3	2.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.0	-1.7	-0.6	-2.0	0.2
Medication: Amlodipine	0.5	0.7	1.8	-0.6	-0.7	-1.3	-0.4
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.4	0.5	0.4	-0.3	-0.7
Birth weight	2.1	4.6	10.4	1.1	0.6	-2.5	-3.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	0.5	-1.2	1.1	0.3
High blood pressure (siblings)	0.2	0.3	0.6	0.2	0.6	-0.8	0.4
Forced vital capacity (FVC), Best measure	0.4	1.6	3.6	-0.6	1.9	-1.6	-0.0
Body fat percentage	2.1	8.3	22.5	-3.2	-0.1	-0.5	4.7
Leg fat percentage (right)	0.8	2.8	9.3	-1.1	0.7	-0.3	3.0
Arm fat-free mass (right)	0.6	3.0	8.0	1.7	2.8	-0.3	-1.0
Exposure to tobacco smoke outside home	2.5	3.4	6.5	2.6	2.2	0.6	-1.4
Comparative body size at age 10	0.9	2.5	6.2	-2.5	-0.5	0.2	1.8
Number of full brothers	2.3	2.9	5.3	-1.1	1.1	-2.3	1.9
Worry too long after embarrassment	0.7	1.1	4.0	-0.4	-2.0	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	0.1	0.5	-0.8	-1.3
Wheeze or whistling in the chest in last year	0.9	1.5	3.3	-0.2	1.1	1.2	1.8
Number of children fathered	0.4	0.5	1.1	-0.2	-1.1	-0.6	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	3.3	3.9	7.3	2.4	1.4	0.7	-2.7
Age at first live birth	0.4	0.8	2.6	0.4	0.2	-0.5	-1.6
Pulse wave peak to peak time	1.8	2.2	3.4	-1.8	1.3	-1.7	0.9
Health satisfaction	0.6	0.8	1.8	-0.4	1.1	0.1	1.3
Shortness of breath walking on level ground	0.9	1.0	2.9	0.7	1.7	-0.7	0.4
Qualifications: College or University degree	0.4	1.4	3.9	-0.2	-0.0	-1.3	-2.0
Eye problems/disorders: None of the above	0.3	0.3	0.9	-1.0	-0.2	-0.5	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.2	-0.7	0.1	-0.9	1.1
Emphysema/chronic bronchitis	1.0	1.1	2.0	1.4	1.3	0.9	0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	2.5	0.8	-1.6	0.5	-0.7
Neck or shoulder pain in last month	2.9	4.1	9.1	-0.7	3.0	-2.5	-0.5
Medication: Blood pressure	0.4	0.8	1.4	-1.2	-0.7	-1.1	0.3
Angina (self-reported)	0.1	0.2	0.2	-0.4	0.5	-0.3	0.4
Migraine (self-reported)	1.2	1.4	2.6	-1.1	1.6	-1.4	0.2
Medication: Ibuprofen	1.7	2.0	3.9	1.6	2.0	0.4	-1.1
Medication: Allopurinol	1.1	1.5	2.9	-1.7	0.4	0.1	1.7
Medication: Omeprazole	0.5	0.6	0.9	0.7	-0.0	1.0	0.9
Medication: Seretide 50 evohaler	0.3	0.4	0.7	-0.9	0.0	-0.5	0.8
Mean time to correctly identify matches	0.8	1.5	3.4	-1.8	-0.2	0.5	1.5
Heart disease (mother)	0.2	0.2	0.7	-0.4	0.0	0.9	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.7	-0.7	-0.1	0.3	0.9
Whole body fat mass	1.3	5.6	15.7	-2.5	0.4	-0.4	4.0
Leg fat mass (right)	0.6	2.4	7.5	-1.0	0.9	-0.5	2.7
Arm predicted mass (right)	0.6	3.1	8.2	1.8	2.9	-0.2	-1.0
Pulse rate, automated reading	0.6	2.0	6.2	0.6	-0.7	-2.5	-1.0
Alcohol intake frequency.	0.2	0.5	0.8	-0.9	-0.3	0.8	0.7
Comparative height size at age 10	0.2	1.1	3.1	-0.7	1.8	-0.9	-0.2
Number of full sisters	1.1	1.3	2.0	0.3	1.2	1.4	1.3
Suffer from ‘nerves’	0.2	0.3	0.8	0.0	0.4	0.2	0.9
Overall health rating	1.2	2.6	8.4	-0.0	2.9	0.5	1.3
Chest pain or discomfort	0.7	1.1	2.1	1.4	1.5	0.5	0.0
Had major operations	1.3	1.5	2.9	1.7	1.4	0.4	-1.1
Age at last live birth	0.5	0.7	2.0	0.3	-0.9	0.1	-1.4
Family relationship satisfaction	0.3	0.3	1.0	-0.3	-1.0	-0.0	-0.3
Leg pain on walking	2.3	2.9	4.9	1.6	2.2	0.2	-2.0
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.1	6.0	0.5	-2.4	2.5	0.3
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.8	1.3	1.7	-0.1	-0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.7	-0.1	-0.1	-0.6	-1.3
Medication: Aspirin	0.3	0.4	1.3	0.3	0.4	-0.1	-1.1
Supplements: Vitamin C	0.8	1.0	2.1	1.3	-0.2	-0.4	-1.5
Knee pain experienced in last month	1.9	2.9	5.7	0.8	2.4	-1.3	-1.9
Hypertension (Self-reported)	0.8	2.3	4.6	-2.1	-0.6	-1.4	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.4	-0.4	1.2	0.9	1.6
Illnesses of father: Heart disease	1.8	2.5	5.7	-1.9	-0.0	-2.4	0.7
Illnesses of siblings: Diabetes	1.3	1.6	2.5	-1.3	-0.8	-1.2	1.6
Smoking status: Previous	2.3	3.4	9.1	-0.8	-0.4	2.0	3.0
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	3.8	1.7	1.7	-0.9	-2.0
Whole body fat-free mass	0.5	2.6	5.6	1.7	2.4	-0.4	-1.3
Leg fat-free mass (right)	0.1	0.3	1.0	0.1	1.0	-0.6	0.2
Arm fat percentage (left)	2.5	10.0	24.9	-3.8	-0.8	-0.4	5.0
Average weekly red wine intake	0.1	0.1	0.3	-0.1	-0.6	0.1	0.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	-0.4	0.1	1.3	0.1
Mood swings	0.0	0.0	0.1	0.2	-0.0	0.1	0.4
Loneliness, isolation	0.5	0.7	1.8	0.0	1.0	-1.4	-0.2
Long-standing illness, disability or infirmity	0.5	0.8	2.0	1.4	0.7	0.7	-0.2
Ever had bowel cancer screening	0.4	0.4	1.1	0.3	-0.4	-1.0	-0.6
Diabetes diagnosed by doctor	0.1	0.1	0.4	0.2	0.0	0.6	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.8	0.9	2.2	0.2	-0.5
Friendships satisfaction	0.6	0.7	1.6	0.3	-0.2	-1.2	-1.1
Qualifications: nursing, teaching	0.5	0.7	1.3	0.1	-0.7	-1.2	-1.0
Commuting to job workplace: Walk	0.3	0.4	0.8	-0.9	-0.3	-0.5	-0.5
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.1	-0.2	0.0	0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	0.9	0.9	-0.9	0.8	-0.6
Medication for cholesterol	0.5	0.8	1.1	0.7	0.8	-0.9	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	0.9	-0.2	-1.1	-0.6
Back pain experienced in last month	1.3	2.0	4.1	-0.6	2.0	-1.5	1.1
Mineral and other dietary supplements	0.4	0.5	1.3	-0.5	-1.2	0.5	0.3
Breast cancer (self-reported)	2.8	3.3	7.1	1.3	-1.8	2.7	-0.9
Asthma (self-reported)	0.7	1.3	2.0	-1.4	1.1	-0.5	1.3
Osteoporosis (self-reported)	1.4	1.7	3.5	1.9	1.1	-1.2	-0.9
Osteoarthritis (self-reported)	0.9	1.2	1.6	1.2	1.2	0.5	-1.3
Medication: Aspirin	0.7	0.9	1.9	0.6	0.9	-0.6	-1.4
Medication: Gliclazide	1.1	1.2	3.0	-0.0	-1.7	1.3	0.5
Illnesses of father: None of the above (group 1)	0.8	1.0	2.4	1.1	0.6	1.6	-0.3
Smoking status: Current	2.7	4.3	8.3	-0.7	-1.6	2.9	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.7	-1.3	-0.7	-1.2	0.5
Whole body water mass	0.5	2.6	5.9	1.6	2.4	-0.5	-1.3
Leg predicted mass (right)	0.1	0.4	1.1	0.1	1.0	-0.6	0.1
Arm fat mass (left)	1.5	6.3	16.2	-2.9	0.1	-0.7	4.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	0.3	0.6	-0.0	0.1
Average weekly champagne plus white wine intake	0.2	0.3	0.7	-0.8	-0.6	-0.2	-0.0
Miserableness	0.8	1.4	2.4	-1.6	-1.5	0.2	1.1
Guilty feelings	1.4	2.2	4.8	1.0	2.2	-0.7	-1.5
Wears glasses or contact lenses	0.5	0.5	0.9	-1.0	-0.3	0.6	0.9
Ever taken oral contraceptive pill	0.7	0.8	2.4	0.9	-0.1	1.5	0.3
Hearing aid user	1.6	1.8	3.4	-0.6	-1.8	-1.2	1.4
Mother’s age at death	0.4	0.6	1.0	0.7	-0.5	1.0	-0.7
Financial situation satisfaction	0.6	0.8	1.6	-1.1	-0.2	-0.4	1.3
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.2	0.3	-0.7	-1.5	-1.2
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.8	-0.8	0.3	-0.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	0.6	0.1	-0.8	-0.3
Medication: Blood pressure	0.5	1.0	1.8	-0.9	1.3	-0.2	1.1
Pain type(s) experienced in last month: Hip pain	1.4	1.8	3.8	-0.6	2.0	-0.6	1.6
Supplements: Fish oil (including cod liver oil)	1.5	2.0	3.9	1.3	2.0	-0.9	-1.2
High cholesterol (Self-reported)	0.5	1.0	1.7	-0.7	1.2	-1.3	0.3
Medication: Bendroflumethiazide	0.3	0.4	1.0	-0.2	1.0	-0.8	-0.3
Medication: Paracetamol	0.2	0.4	1.0	-0.1	1.0	-0.6	0.4
Medication: Lisinopril	1.1	1.4	2.5	-1.1	1.2	-0.5	1.6
Medication: Atorvastatin	0.9	1.1	4.1	-0.4	-0.2	-2.0	0.2
Illnesses of father: High blood pressure	2.1	2.6	8.4	-1.4	-0.0	-2.9	0.2
Alcohol drinker status: Never	1.6	2.0	3.5	1.9	-0.5	1.1	-1.7
Ever smoked	3.2	5.6	12.5	-0.8	-1.0	2.9	3.5
Basal metabolic rate	0.3	1.5	4.7	1.0	2.2	-0.5	-0.4
Leg fat percentage (left)	0.9	3.2	10.8	-1.2	0.6	0.1	3.3
Arm fat-free mass (left)	0.6	3.1	9.3	1.5	3.0	-0.5	-0.8
Number of operations (self-reported)	1.5	2.2	4.5	2.1	1.6	1.1	-0.9
Average weekly beer plus cider intake	1.4	2.0	5.0	0.9	2.2	1.5	0.4
Irritability	0.0	0.1	0.3	0.6	0.0	-0.0	0.0
Risk taking	0.3	0.5	0.9	0.8	0.1	-0.6	-0.9
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.2	-0.4	-0.4	-1.1	-0.7
Fractured/broken bones in last 5 years	1.1	1.4	4.2	2.0	0.8	0.4	-0.8
Age started oral contraceptive pill	0.8	1.0	3.3	0.0	-0.5	-0.5	-1.8
Diastolic blood pressure, automated reading	1.1	3.5	5.5	-2.3	-0.8	-2.3	1.5
Ever depressed for a whole week	0.3	0.4	1.1	0.0	-1.1	0.1	-0.8
Unable to work because of sickness or disability	2.8	3.6	6.8	2.6	1.6	1.6	-1.6
Commuting to job workplace: Cycle	0.5	0.6	1.8	0.6	0.1	-0.2	-1.4
Myopia	0.1	0.1	0.3	-0.3	0.2	-0.3	-0.5
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.0	1.7	0.3	0.6	-1.3
Cholesterol lowering medication	0.7	1.0	2.9	0.6	1.7	0.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	1.1	0.7	0.8	0.4
Pain experienced in last month	1.2	2.0	4.0	-0.9	-2.0	1.5	1.0
Supplements: Calcium	1.4	1.6	3.6	0.9	1.9	1.3	-0.3
Basal cell carcinoma (self-reported)	2.5	2.9	5.8	1.9	2.4	-0.7	-1.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	-0.0	-0.3	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.5	-1.2	0.9	0.3	0.7
Heart disease (siblings)	0.8	1.0	2.4	-0.6	-0.4	-1.5	-1.1
Alcohol drinker status: Previous	1.2	1.4	4.6	0.7	-0.6	2.1	0.5
Pack years of smoking	0.1	0.1	0.4	-0.6	-0.2	0.1	0.1
Impedance of whole body	0.1	0.6	1.3	-1.1	-0.6	-0.5	0.7
Leg fat mass (left)	0.7	2.7	8.5	-1.1	0.9	-0.4	2.9
Arm predicted mass (left)	0.6	2.8	7.8	1.6	2.8	-0.5	-0.9