Hub : Genes

GTF3C6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0890	0.0390	0.00140	0.023	NA	0.029	NA	0.015	0.005	NA	0.002	NA	0.0200
2	GTEx	Brain Hypothalamus	0.3240	0.1100	0.00082	0.039	NA	0.046	NA	0.079	0.044	NA	0.032	NA	0.0068
3	TCGA	Head and Neck Squamous Cell Carcinoma	0.0362	0.0263	0.00560	0.012	0.005	0.013	NA	-0.002	0.013	0.084	0.012	NA	0.7500
4	TCGA	Brain Lower Grade Glioma	0.0297	0.0218	0.00500	-0.001	0.007	-0.002	NA	-0.001	0.390	0.050	0.950	NA	0.4800

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.6	0.8	-0.6	-0.2	0.4
Bipolar Disorder or Schizophrenia	0.9	2.1	6.0	2.4	0.2	1.5	0.6
Depressed Affect (Nagel 2018)	0.5	0.9	2.8	1.7	-0.8	-0.6	-0.2
Depression (Nagel 2018)	0.8	1.3	4.5	2.1	0.6	0.1	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.5	3.7	-1.4	-0.0	-1.9	-0.6
Neuroticism (Nagel 2018)	0.7	1.6	4.1	2.0	1.3	0.2	0.8
Schizophrenia (2018)	1.4	2.8	6.4	2.5	0.7	2.0	0.4
Schizophrenia vs Biploar Disorder	1.1	1.5	4.4	-0.5	2.1	0.3	-1.1
Worry (Nagel 2018)	1.9	4.0	9.7	1.8	3.1	0.6	1.7
Alzheimer’s Disease (in mother)	0.6	0.7	1.6	-0.7	1.3	-0.5	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.7	0.0	-0.8	0.8	-0.4
Alzheimer’s Disease (including proxy)	0.7	1.0	2.5	-1.0	0.3	-0.4	-1.6
Crohns Disease (2017)	0.6	1.4	3.6	0.2	-0.3	1.3	-1.9
Irritable Bowel Disease (IBD)	0.3	0.7	1.4	-1.2	0.6	-0.1	-1.1
Ulcerative Colitis (UC)	0.9	1.6	3.6	-1.9	1.4	-1.0	-0.1
Major Depression (MDD)	0.5	0.6	1.1	0.8	-1.0	0.6	-0.3
Reaction Time	0.6	1.1	1.7	-1.2	1.1	-1.3	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	-0.0	0.7	0.7	-0.5
Breast Cancer	0.5	1.1	1.4	1.2	-1.2	0.7	1.1
Ovarian Cancer	0.2	0.3	0.8	0.4	0.9	-0.1	0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.1	0.2	0.3	0.4	0.0	0.5	0.5
Bipolar Disorder (2011)	0.4	0.4	1.4	1.2	-0.3	-0.0	-0.4
Body Mass Index (BMI) (2010)	0.8	1.1	3.6	0.8	0.4	0.2	1.9
Coronary Artery Disease (CAD)	1.8	2.1	4.0	-1.1	-1.7	-2.0	-0.6
Crohns Disease (2012)	0.6	1.0	1.9	1.0	-0.1	1.1	-1.4
Mean Putamen Volume	1.8	2.0	3.6	-1.7	0.3	-1.9	-1.2
Fasting Glucose	0.4	0.5	0.9	-0.8	0.9	-0.4	-0.7
HbA1C	0.9	1.0	3.0	-0.9	-0.5	0.3	-1.7
HDL Cholesterol	1.3	2.2	4.3	-2.1	-0.4	-1.2	-1.7
LDL Cholesterol	0.4	0.6	1.3	0.8	1.1	0.5	0.3
Lupus	0.9	1.4	2.2	-1.5	-1.4	-1.0	-0.7
Neuroticism (2016)	0.9	1.2	2.4	1.1	1.5	1.0	0.6
Primary Biliary Cirrhosis	1.3	1.9	3.5	1.6	-1.9	0.6	1.1
Rheumatoid Arthritis	0.7	1.0	2.0	1.4	0.7	0.6	-1.0
Schizophrenia (2014)	1.3	2.8	5.6	2.4	1.1	2.1	0.2
Triglycerides	1.0	1.6	3.5	0.8	-1.4	0.3	1.9
Type 2 Diabetes (T2D) (2012)	1.4	1.6	5.8	0.2	-2.4	0.5	-0.4
Ulcerative Colitis	0.3	0.5	1.2	-1.1	0.2	-0.8	0.2
Blood Eosinophil Count	0.7	5.5	10.5	2.5	-3.2	0.8	2.1
Blood Platelet Count	0.1	0.6	1.0	1.0	0.3	-0.8	-0.8
Blood Red Count	1.4	13.4	27.2	3.2	5.2	3.3	2.2
Blood White Count	0.1	0.5	1.9	1.4	-0.2	0.4	-0.2
Heel T-Score	0.2	1.2	2.4	0.3	-1.5	1.5	-0.1
BMI	1.2	7.2	22.9	0.9	-4.8	-2.3	0.0
Height	0.3	5.7	9.4	-2.6	0.3	-2.6	-3.1
Waist Hip Ratio (WHR)	0.2	1.1	1.9	-0.2	-0.9	1.3	1.4
Systolic Blood Pressure	0.5	2.7	4.6	-2.0	1.2	-0.8	-2.1
Smoking Status	9.3	22.3	81.3	2.3	-9.0	-0.1	-1.5
Allergy or Eczema	0.7	1.9	5.2	2.3	-0.3	1.3	0.7
Cardiovascular Disease	0.4	1.4	2.4	1.5	-0.3	0.9	1.5
Hypothyroidism (self reported)	0.3	0.7	2.1	-0.0	1.5	0.4	0.8
Respiratory disease	0.0	0.0	0.1	0.3	-0.1	0.0	-0.2
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.4	1.2	-2.1	0.2	0.2
Lung FEV1/FVC ratio	0.2	0.8	1.2	-0.4	0.9	-1.1	-1.0
Lung FVC	0.2	0.9	2.7	-0.5	1.6	0.9	0.1
Neuroticism	1.6	3.9	9.1	3.0	1.7	1.0	1.6
Chronotype (morning person)	1.6	3.8	8.8	-3.0	2.2	-0.3	-1.1
Hair Pigment	0.1	3.7	6.4	-2.4	2.5	-1.6	-0.0
Tanning	0.3	3.1	5.4	-2.3	1.5	-1.1	-1.9
Hand grip strength (left)	1.1	2.9	7.1	1.5	2.7	1.4	0.5
Number of treatments/medications taken	2.3	4.1	6.2	2.5	-2.1	0.6	2.3
Average weekly spirits intake	0.1	0.1	0.4	-0.2	0.6	-0.2	-0.0
Sensitivity / hurt feelings	1.9	3.3	7.1	2.7	0.8	2.3	-0.1
Frequency of depressed mood in last 2 weeks	1.2	1.7	5.1	2.3	1.2	-0.1	0.6
Hearing difficulty/problems: Yes	1.2	1.9	5.2	-0.5	-0.2	-1.5	-2.3
Relative age of first facial hair	0.4	0.9	1.7	0.2	1.3	0.9	-1.0
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	0.9	-0.7	1.5	-0.0
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.6	1.5	-1.9	-0.5	-0.3
Ever had hysterectomy (womb removed)	1.5	1.7	3.1	1.5	-0.7	1.8	0.9
Systolic blood pressure, automated reading	1.6	4.6	7.2	-2.5	0.8	-2.1	-2.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.4	-0.5	0.1	-1.2	-0.6
Angina	0.0	0.0	0.1	-0.1	0.3	-0.1	-0.2
Medication for hormone replacement therapy	3.1	3.5	9.1	1.9	-3.0	1.0	-0.3
Vitamin and mineral supplements	0.8	1.0	3.8	0.2	0.4	0.2	1.9
Supplements: Zinc	0.7	0.8	1.9	-1.4	-0.0	-0.9	-0.7
Medication: Co-codamol	0.8	0.9	1.8	1.4	-0.6	0.7	0.9
Medication: Metformin	1.3	1.8	6.9	0.2	-2.6	-0.5	-0.0
Diabetes (father)	0.5	0.7	2.5	-1.6	0.2	-0.2	0.4
Diabetes (mother)	0.5	0.6	1.6	0.5	0.3	1.2	0.8
Severe depression (siblings)	2.9	3.3	10.0	-1.2	-0.6	-1.1	-3.2
Pack years adult smoking proportion	0.4	0.6	1.0	0.5	-1.0	1.0	0.5
Impedance of leg (right)	0.1	0.6	1.4	0.5	0.2	1.2	0.7
Leg fat-free mass (left)	0.4	2.4	3.2	-0.9	-1.8	-1.7	-1.6
Trunk fat percentage	1.4	5.8	17.6	1.4	-4.2	-1.7	0.8
Hand grip strength (right)	0.9	2.6	4.2	1.6	2.1	1.7	0.9
Townsend deprivation index at recruitment	4.2	5.9	13.0	3.6	-1.6	2.5	1.3
Current tobacco smoking	4.5	7.3	17.0	3.3	-4.1	1.2	0.1
Average weekly fortified wine intake	0.1	0.1	0.2	-0.1	-0.4	-0.4	-0.3
Maternal smoking around birth	2.8	4.0	15.2	0.4	-3.9	0.1	-0.8
Fed-up feelings	1.8	3.2	7.6	2.7	-1.5	1.6	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.6	1.9	0.4	0.0	0.9
Relative age voice broke	0.7	1.1	2.8	-0.4	1.1	-0.1	-1.7
Taking other prescription medications	1.5	2.4	6.0	1.6	-2.4	0.8	0.7
Age when periods started (menarche)	1.1	2.7	5.7	1.9	-0.9	0.9	2.4
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.3	1.5	-1.5	0.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.6	-0.4	-0.7	1.2	0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.1	-0.9	-1.4	-1.4	-0.1
Qualifications: CSEs or equivalent	0.7	0.9	2.3	1.1	0.0	-0.2	1.5
Serious illness, injury or assault to yourself	0.9	1.1	2.1	1.4	-1.4	0.8	-0.1
High blood pressure	0.4	1.2	2.9	0.8	-0.2	1.2	1.7
Hayfever, allergic rhinitis or eczema	1.7	3.7	8.1	2.9	-0.8	2.1	1.3
Multivitamins +/- minerals	0.3	0.4	1.4	-0.1	0.2	-0.4	-1.2
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.5	0.1	0.2	-0.5
Supplements: Glucosamine	1.0	1.2	3.0	-0.7	-0.5	-1.1	-1.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.5	0.3	0.3	0.6
Medication: Atenolol	0.5	0.7	2.4	-0.1	-0.3	0.5	1.5
Medication: Levothyroxine sodium	0.6	1.0	3.1	-0.3	1.8	0.5	0.8
Sitting height	0.2	1.6	3.4	-1.1	1.8	0.2	-1.3
Chronic bronchitis/emphysema (father)	1.4	1.6	4.9	-0.9	-2.2	-0.9	0.1
High blood pressure (mother)	0.9	1.2	3.0	-1.3	1.7	0.4	-0.2
Body mass index (BMI)	1.1	4.6	15.4	1.0	-3.9	-0.9	1.0
Impedance of leg (left)	0.2	0.8	1.4	0.6	0.3	1.2	1.2
Leg predicted mass (left)	0.5	2.6	3.5	-1.0	-1.9	-1.7	-1.7
Trunk fat mass	1.0	4.4	13.8	0.9	-3.7	-1.6	0.5
Waist circumference	0.8	3.1	9.7	0.6	-3.1	-0.7	1.3
Number of incorrect matches in round	0.8	1.3	2.9	1.7	0.5	0.6	1.4
Past tobacco smoking	9.1	16.7	63.9	-0.8	8.0	0.9	1.1
Alcohol usually taken with meals	1.2	1.9	4.4	-2.1	1.6	0.7	-0.4
Nervous feelings	2.1	3.9	5.6	2.1	2.4	1.0	2.1
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	8.6	1.0	2.9	0.4	0.4
Hearing difficulty/problems with background noise	0.4	0.6	1.7	0.7	-0.1	-0.6	-1.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	-0.0	-0.0	0.5
Had menopause	0.4	0.5	1.6	0.0	-1.3	-0.7	-0.3
Had other major operations	2.5	3.1	7.0	2.6	-0.8	2.0	0.8
Forced vital capacity (FVC)	0.6	2.4	5.2	-1.6	2.3	-0.0	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.8	-0.3	-0.8	1.3	0.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.9	1.5	0.2	1.7	0.1
Qualifications: None of the above	0.7	1.5	1.8	1.3	-1.1	1.3	1.2
Financial difficulties in last 2 years	2.1	2.9	6.6	2.6	-1.1	1.9	-0.3
Mouth/teeth dental problems	0.2	0.3	0.7	0.3	0.5	0.2	0.8
Heart attack	0.6	0.8	1.3	-0.9	-1.2	-0.8	0.6
Allergy	0.7	1.6	4.4	-2.1	1.0	-1.1	-0.0
Pain all over the body in last month	0.6	0.7	2.7	1.6	-0.1	-0.0	0.0
Diabetes (self-reported)	0.6	0.9	1.9	1.2	-1.4	0.7	0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.7	0.6	-0.5	1.6	1.5
Medication: Ramipril	0.5	0.6	0.9	-1.0	-0.8	0.3	-0.9
Medication: Simvastatin	1.7	2.6	7.0	1.6	0.3	0.7	2.7
Fluid intelligence score	0.3	0.5	1.7	0.5	1.3	0.0	-0.4
Illnesses of siblings	0.8	1.1	1.9	-1.3	-0.9	-1.4	-0.4
Neuroticism score	2.1	4.3	12.0	3.5	1.4	1.7	0.7
Weight	0.6	3.2	9.8	-0.2	-3.1	-1.7	-0.2
Impedance of arm (right)	0.2	0.9	2.9	0.6	1.7	-0.3	-0.4
Arm fat percentage (right)	1.2	4.6	13.2	1.2	-3.6	-1.5	1.2
Trunk fat-free mass	0.3	1.7	3.7	-1.9	-0.2	-1.2	-1.4
Hip circumference	0.5	2.0	5.3	1.0	-2.3	-1.0	1.0
Time employed in main current job	0.8	0.9	1.9	0.0	1.3	1.4	0.3
Alcohol intake versus 10 years previously	4.0	6.0	10.4	3.2	-1.6	3.0	1.4
Father’s age at death	2.3	3.1	5.6	-2.4	1.5	-1.2	-1.8
Worrier / anxious feelings	4.0	7.5	14.9	2.7	3.9	1.9	2.1
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	9.6	3.1	-0.9	1.2	1.5
Falls in the last year	0.4	0.5	1.3	-0.7	-0.4	-0.2	-1.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.2	-0.7	0.1	-1.1	-0.2
Number of live births	0.6	0.8	1.3	0.9	0.6	0.9	1.2
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	5.8	-1.9	2.4	-0.1	-1.4
Pulse rate	2.7	4.6	8.9	3.0	1.2	2.4	1.5
Happiness	1.0	1.2	2.1	1.5	0.7	0.6	1.4
Noisy workplace	0.5	0.6	1.7	-0.1	0.0	0.9	-1.3
Qualifications: A levels/AS levels or equivalent	1.3	2.8	6.0	-2.4	1.7	-0.0	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.3	-0.2	1.2	1.0	0.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.2	-0.5	-1.1	-1.1	-0.6
Asthma	0.1	0.3	0.6	-0.5	-0.8	-0.4	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.0	-0.7	0.7	-0.1
Medication: Cholesterol lowering	1.1	1.6	3.9	0.9	1.0	1.0	2.0
Depression (self-reported)	0.2	0.3	0.3	0.4	0.5	0.6	0.6
Medication: Lansoprazole	0.8	0.9	3.0	0.3	-1.7	0.0	-0.8
Prospective memory result	1.5	1.9	5.0	2.2	0.3	0.7	1.4
Lung cancer (father)	1.8	2.1	4.1	1.4	0.0	1.6	2.0
Illnesses of mother	1.0	1.2	2.6	0.4	-1.6	-1.1	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.3	-0.1	1.8	0.8	-1.6
Pulse wave Arterial Stiffness index	0.8	0.9	2.3	0.1	-0.9	-1.5	-0.7
Impedance of arm (left)	0.1	0.6	1.9	0.7	1.4	-0.3	-0.3
Arm fat mass (right)	1.0	4.3	13.2	0.5	-3.6	-1.7	0.7
Trunk predicted mass	0.3	1.6	3.3	-1.8	-0.2	-1.1	-1.3
Standing height	0.5	4.6	7.0	-2.6	1.2	-1.8	-2.6
Length of working week for main job	1.1	1.2	1.7	-0.8	-1.3	-1.1	-1.2
Exposure to tobacco smoke at home	0.9	1.0	3.1	0.6	-1.8	0.4	0.5
Breastfed as a baby	0.4	0.5	1.1	0.8	0.5	0.4	1.0
Tense / ‘highly strung’	0.5	0.8	2.8	-0.0	1.7	-0.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	0.5	-1.3	-0.5	-1.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.4	0.5	-0.3	-0.4	-1.2
Birth weight of first child	0.6	1.0	2.7	-1.1	0.5	-1.7	0.1
Peak expiratory flow (PEF)	1.2	2.7	4.0	-2.0	1.3	-1.2	-2.0
Pulse wave reflection index	1.9	2.3	5.6	-0.8	-2.4	-1.5	-1.0
Ever highly irritable/argumentative for 2 days	2.6	3.1	5.4	2.1	1.0	2.3	1.2
Loud music exposure frequency	1.1	1.2	3.6	-1.9	0.3	0.4	-0.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	4.2	-1.2	2.1	0.3	-0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	2.7	0.6	-1.6	-1.1	0.3
Blood clot in the leg (DVT)	0.9	1.1	2.3	-0.2	-1.2	-1.5	-0.8
Medication: Paracetamol	0.5	0.8	1.7	0.1	-1.2	-0.6	-1.3
Headache pain in last month	1.2	2.0	4.6	2.1	-1.4	0.7	-1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.9	-0.8	-1.0	-0.9	-0.6
Glaucoma (self-reported)	0.7	0.8	1.7	-1.1	0.5	-1.3	-0.0
Gout (self-reported)	0.4	0.6	1.2	-0.4	-0.9	-1.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.5	-0.0	1.2	0.1	1.2
Medication: Amlodipine	1.6	2.2	3.9	1.7	0.3	1.4	2.0
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.9	-1.7	-0.3	-1.1	-1.5
Birth weight	3.3	7.2	11.8	-3.4	1.6	-2.7	-2.7
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.4	0.8	-0.6	1.6	0.3
High blood pressure (siblings)	0.5	0.8	1.4	0.9	1.2	0.8	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.2	2.3	-0.4	1.5	0.4	-1.4
Body fat percentage	1.5	6.1	17.8	1.5	-4.2	-1.5	1.4
Leg fat percentage (right)	1.9	6.9	20.2	1.6	-4.5	-0.5	2.1
Arm fat-free mass (right)	0.3	1.7	3.3	-1.2	-1.8	-1.1	-0.9
Exposure to tobacco smoke outside home	1.4	1.8	3.6	0.4	-0.6	1.9	-1.8
Comparative body size at age 10	1.4	3.8	6.5	-1.4	-2.0	-2.5	-1.7
Number of full brothers	3.9	4.9	8.4	2.1	-2.5	1.0	2.9
Worry too long after embarrassment	2.1	3.4	7.3	2.7	2.1	1.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	4.7	2.2	0.2	1.6	0.4
Wheeze or whistling in the chest in last year	0.8	1.3	3.7	-0.3	-1.0	-0.8	-1.9
Number of children fathered	0.6	0.7	2.4	-0.2	1.6	-0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.9	0.6	2.0	1.1	-1.9
Age at first live birth	1.7	3.0	5.4	-1.8	2.3	-1.6	-1.1
Pulse wave peak to peak time	0.7	0.9	1.9	-0.1	1.1	1.4	0.6
Health satisfaction	0.3	0.4	1.1	0.1	-1.0	-0.3	0.6
Shortness of breath walking on level ground	1.0	1.2	4.4	2.1	0.6	0.3	0.3
Qualifications: College or University degree	1.9	6.1	11.3	-3.0	0.8	-1.8	-3.4
Eye problems/disorders: None of the above	0.9	1.1	2.9	0.0	1.7	0.7	-1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	0.5	0.2	0.8	-0.6
Emphysema/chronic bronchitis	0.6	0.7	2.0	0.7	0.2	0.4	-1.4
Medication for pain relief, constipation, heartburn	1.6	2.6	10.2	-0.6	3.2	-0.2	-0.0
Neck or shoulder pain in last month	0.5	0.7	2.0	1.4	0.1	0.5	-0.8
Medication: Blood pressure	0.1	0.1	0.2	0.3	0.4	0.5	-0.1
Angina (self-reported)	0.0	0.0	0.1	-0.1	0.1	-0.3	-0.1
Migraine (self-reported)	0.5	0.6	1.9	-0.4	-1.4	0.5	-0.2
Medication: Ibuprofen	0.2	0.2	0.5	-0.4	-0.7	0.1	-0.4
Medication: Allopurinol	0.2	0.3	0.6	-0.2	-0.7	-0.2	0.7
Medication: Omeprazole	1.0	1.2	4.3	0.5	-2.1	-0.5	-0.2
Medication: Seretide 50 evohaler	1.7	2.0	3.8	-1.3	-0.3	-1.5	-2.0
Mean time to correctly identify matches	0.6	1.1	2.2	-1.4	0.4	-1.5	-0.3
Heart disease (mother)	0.5	0.7	1.4	-0.8	0.7	-0.4	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	-0.6	-0.9	0.4	0.5
Whole body fat mass	1.2	5.2	17.1	0.8	-4.1	-1.6	0.6
Leg fat mass (right)	1.4	5.5	19.2	0.5	-4.4	-1.4	0.8
Arm predicted mass (right)	0.3	1.5	2.7	-1.2	-1.6	-1.0	-0.9
Pulse rate, automated reading	0.9	2.8	7.1	2.7	1.4	1.0	1.2
Alcohol intake frequency.	0.9	2.1	2.9	1.7	-1.1	1.3	1.7
Comparative height size at age 10	0.4	2.1	4.7	-2.2	0.5	-1.5	-1.1
Number of full sisters	1.5	1.8	2.9	1.3	-1.1	1.7	1.2
Suffer from ‘nerves’	1.3	2.0	5.5	1.5	2.4	0.3	-0.2
Overall health rating	2.2	4.7	11.2	3.4	-1.6	1.6	1.6
Chest pain or discomfort	0.6	0.9	1.6	0.8	-0.8	0.7	-1.3
Had major operations	0.4	0.5	0.9	0.9	0.3	1.0	-0.4
Age at last live birth	1.6	2.3	3.5	-1.6	1.9	-1.4	-1.1
Family relationship satisfaction	0.2	0.2	0.6	0.5	-0.4	-0.8	-0.1
Leg pain on walking	0.3	0.4	1.4	0.2	-0.0	0.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	1.0	-0.4	-0.1	0.8
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	0.9	0.1	1.5	-0.3
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	2.9	-1.5	1.6	-1.7	1.1
Medication: Aspirin	1.6	2.1	4.5	0.8	-1.5	1.1	2.1
Supplements: Vitamin C	0.6	0.7	1.7	-1.3	-0.1	-0.2	-1.0
Knee pain experienced in last month	0.3	0.5	1.2	0.8	-0.1	1.1	-0.3
Hypertension (Self-reported)	0.5	1.3	3.2	0.9	0.1	1.0	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.7	0.3	-1.6	-0.1	-1.1
Illnesses of father: Heart disease	0.1	0.2	0.4	-0.1	-0.4	-0.7	0.3
Illnesses of siblings: Diabetes	0.1	0.2	0.6	0.7	-0.3	-0.0	0.2
Smoking status: Previous	6.6	9.9	37.5	-0.0	-6.1	-1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.7	-0.9	0.5	-1.2	-1.6
Whole body fat-free mass	0.3	2.0	2.5	-1.6	-1.0	-1.5	-1.5
Leg fat-free mass (right)	0.4	1.9	2.6	-0.8	-1.5	-1.6	-1.5
Arm fat percentage (left)	1.3	5.1	15.2	1.2	-3.9	-1.4	1.3
Average weekly red wine intake	1.9	2.8	6.8	-0.7	2.6	0.6	-1.9
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.4	-0.2	-0.6	-0.4	0.4
Mood swings	0.3	0.6	1.5	1.2	-0.5	0.6	0.4
Loneliness, isolation	0.9	1.2	1.9	1.3	1.4	-1.0	-0.0
Long-standing illness, disability or infirmity	3.2	4.9	15.2	1.7	-3.9	0.9	0.7
Ever had bowel cancer screening	1.0	1.1	2.1	1.4	-0.6	-1.2	0.9
Diabetes diagnosed by doctor	1.3	2.2	4.4	1.8	-2.1	0.8	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	3.0	1.7	0.1	-0.1	-0.1
Friendships satisfaction	0.3	0.3	1.1	0.3	1.1	-0.2	0.0
Qualifications: nursing, teaching	0.9	1.3	2.5	-1.6	0.8	-0.5	-1.4
Commuting to job workplace: Walk	0.4	0.4	0.8	-0.9	0.9	-0.5	0.2
Eye problems/disorders: Cataract	0.1	0.2	0.6	0.1	-0.7	-0.3	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	-0.9	-0.5	0.7	-0.0
Medication for cholesterol	2.4	3.6	6.0	-2.2	2.5	-0.6	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.8	-0.4	0.0	0.7	-1.3
Back pain experienced in last month	2.7	4.0	10.0	3.2	-1.1	1.8	1.2
Mineral and other dietary supplements	2.9	4.0	5.8	2.0	1.1	2.1	2.4
Breast cancer (self-reported)	0.0	0.1	0.2	-0.2	0.0	0.0	-0.4
Asthma (self-reported)	0.1	0.3	0.6	-0.5	-0.8	-0.5	0.1
Osteoporosis (self-reported)	1.5	1.8	3.8	1.0	1.9	1.6	-0.3
Osteoarthritis (self-reported)	0.7	0.9	2.3	0.6	-1.0	-0.1	-1.5
Medication: Aspirin	1.9	2.5	6.2	1.1	-0.7	1.4	2.5
Medication: Gliclazide	0.8	1.0	3.0	0.5	-1.7	-0.6	0.3
Illnesses of father: None of the above (group 1)	0.5	0.7	1.7	-0.6	0.8	-0.2	-1.3
Smoking status: Current	4.3	6.8	16.0	3.2	-4.0	1.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.5	0.2	0.6	0.2
Whole body water mass	0.3	1.7	2.0	-1.4	-1.0	-1.4	-1.3
Leg predicted mass (right)	0.4	1.9	2.4	-0.8	-1.5	-1.5	-1.5
Arm fat mass (left)	1.1	4.7	14.9	0.8	-3.9	-1.6	0.8
Number of self-reported non-cancer illnesses	2.0	3.4	6.4	2.2	-2.5	1.6	0.5
Average weekly champagne plus white wine intake	1.8	2.4	5.3	-2.3	1.2	-0.3	-1.7
Miserableness	0.9	1.5	2.8	1.7	-1.0	0.4	-1.4
Guilty feelings	2.1	3.1	4.4	1.8	2.0	0.9	2.1
Wears glasses or contact lenses	0.5	0.6	1.3	0.6	-1.2	0.3	-0.7
Ever taken oral contraceptive pill	1.6	1.7	3.8	1.0	-1.2	0.8	-2.0
Hearing aid user	0.3	0.3	0.5	0.0	-0.6	-0.7	-0.7
Mother’s age at death	0.4	0.5	1.2	-0.6	1.1	-0.6	0.0
Financial situation satisfaction	0.8	1.0	1.9	1.2	1.4	0.4	0.8
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.3	-1.5	-0.6	-0.5	-1.8
Commuting to job workplace: Public transport	0.8	0.9	2.0	-1.4	0.8	-0.1	-1.0
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.1	0.0	-0.7	0.0
Medication: Blood pressure	1.3	2.4	4.3	2.0	-1.1	0.7	2.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.9	-0.2	-2.0	-0.3	-1.3
Supplements: Fish oil (including cod liver oil)	1.2	1.6	2.4	-1.3	-0.8	-1.2	-1.6
High cholesterol (Self-reported)	2.4	4.2	8.5	2.2	1.0	1.6	2.9
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.4	-0.2	-0.4	-0.1
Medication: Paracetamol	1.1	1.7	2.8	-0.7	-1.3	-1.3	-1.7
Medication: Lisinopril	0.7	0.9	2.2	0.4	0.9	1.5	0.8
Medication: Atorvastatin	0.3	0.4	1.2	0.0	-0.4	0.4	1.1
Illnesses of father: High blood pressure	1.0	1.2	2.9	0.6	1.7	1.1	0.5
Alcohol drinker status: Never	0.2	0.2	0.7	-0.0	-0.8	0.4	0.1
Ever smoked	6.6	11.6	45.4	0.4	-6.7	-0.4	-0.7
Basal metabolic rate	0.3	1.9	3.0	-1.1	-1.7	-1.5	-1.1
Leg fat percentage (left)	1.9	7.0	19.5	1.6	-4.4	-0.6	2.4
Arm fat-free mass (left)	0.2	1.2	2.3	-1.0	-1.5	-1.1	-0.6
Number of operations (self-reported)	1.3	1.9	3.2	1.8	-1.1	1.8	0.4
Average weekly beer plus cider intake	4.8	7.0	11.7	3.4	-2.5	1.7	2.7
Irritability	0.4	0.7	1.6	1.3	-0.7	-0.0	0.8
Risk taking	2.8	4.1	6.2	-2.5	-1.6	-1.1	-2.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	-0.6	-0.3	0.8	0.4
Fractured/broken bones in last 5 years	1.7	2.2	4.4	-1.0	-0.6	-1.7	-2.1
Age started oral contraceptive pill	2.7	3.3	7.1	-1.5	2.7	-1.8	-0.9
Diastolic blood pressure, automated reading	0.8	2.4	4.2	-1.6	1.6	-0.7	-2.0
Ever depressed for a whole week	0.4	0.5	1.0	0.7	-0.8	1.0	0.1
Unable to work because of sickness or disability	0.4	0.5	1.5	-0.2	-1.2	-0.5	-0.4
Commuting to job workplace: Cycle	1.2	1.5	5.7	-0.1	2.4	-0.5	0.1
Myopia	0.7	1.0	3.5	-1.9	-0.6	-0.5	-0.3
Vascular/heart problems diagnosed by doctor	0.5	1.5	3.6	-0.6	0.7	-1.2	-1.9
Cholesterol lowering medication	1.4	2.0	4.2	1.6	-1.1	0.3	2.1
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	3.4	0.5	-1.8	-0.1	-0.0
Pain experienced in last month	1.2	2.1	4.2	-1.6	2.0	-0.5	1.1
Supplements: Calcium	0.1	0.1	0.2	0.5	-0.0	-0.4	-0.1
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	-0.9	0.0	-0.0	-0.9
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.1	-0.7	-0.9	-0.6	1.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.2	-0.1	-1.3	-1.5	-0.8
Heart disease (siblings)	0.3	0.3	0.9	0.6	-0.0	0.9	0.1
Alcohol drinker status: Previous	1.2	1.4	4.1	1.0	-2.0	0.2	0.7
Pack years of smoking	0.2	0.3	0.9	0.3	-0.4	0.9	0.3
Impedance of whole body	0.1	0.5	0.9	0.8	0.9	0.4	0.4
Leg fat mass (left)	1.4	5.5	18.6	0.5	-4.3	-1.5	0.9
Arm predicted mass (left)	0.3	1.6	3.7	-1.0	-1.9	-1.2	-0.6