Hub : Genes

GTF3C6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0890 0.0390 0.00140 0.023 NA 0.029 NA 0.015 0.005 NA 0.002 NA 0.0200
2 GTEx Brain Hypothalamus 0.3240 0.1100 0.00082 0.039 NA 0.046 NA 0.079 0.044 NA 0.032 NA 0.0068
3 TCGA Head and Neck Squamous Cell Carcinoma 0.0362 0.0263 0.00560 0.012 0.005 0.013 NA -0.002 0.013 0.084 0.012 NA 0.7500
4 TCGA Brain Lower Grade Glioma 0.0297 0.0218 0.00500 -0.001 0.007 -0.002 NA -0.001 0.390 0.050 0.950 NA 0.4800

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.6 0.8 -0.6 -0.2 0.4
Bipolar Disorder or Schizophrenia 0.9 2.1 6.0 2.4 0.2 1.5 0.6
Depressed Affect (Nagel 2018) 0.5 0.9 2.8 1.7 -0.8 -0.6 -0.2
Depression (Nagel 2018) 0.8 1.3 4.5 2.1 0.6 0.1 0.6
Intelligence (Savage-Jansen 2018) 0.5 1.5 3.7 -1.4 -0.0 -1.9 -0.6
Neuroticism (Nagel 2018) 0.7 1.6 4.1 2.0 1.3 0.2 0.8
Schizophrenia (2018) 1.4 2.8 6.4 2.5 0.7 2.0 0.4
Schizophrenia vs Biploar Disorder 1.1 1.5 4.4 -0.5 2.1 0.3 -1.1
Worry (Nagel 2018) 1.9 4.0 9.7 1.8 3.1 0.6 1.7
Alzheimer’s Disease (in mother) 0.6 0.7 1.6 -0.7 1.3 -0.5 -0.7
Alzheimer’s Disease (in father) 0.3 0.3 0.7 0.0 -0.8 0.8 -0.4
Alzheimer’s Disease (including proxy) 0.7 1.0 2.5 -1.0 0.3 -0.4 -1.6
Crohns Disease (2017) 0.6 1.4 3.6 0.2 -0.3 1.3 -1.9
Irritable Bowel Disease (IBD) 0.3 0.7 1.4 -1.2 0.6 -0.1 -1.1
Ulcerative Colitis (UC) 0.9 1.6 3.6 -1.9 1.4 -1.0 -0.1
Major Depression (MDD) 0.5 0.6 1.1 0.8 -1.0 0.6 -0.3
Reaction Time 0.6 1.1 1.7 -1.2 1.1 -1.3 0.0
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.5 -0.0 0.7 0.7 -0.5
Breast Cancer 0.5 1.1 1.4 1.2 -1.2 0.7 1.1
Ovarian Cancer 0.2 0.3 0.8 0.4 0.9 -0.1 0.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.1 0.2 0.3 0.4 0.0 0.5 0.5
Bipolar Disorder (2011) 0.4 0.4 1.4 1.2 -0.3 -0.0 -0.4
Body Mass Index (BMI) (2010) 0.8 1.1 3.6 0.8 0.4 0.2 1.9
Coronary Artery Disease (CAD) 1.8 2.1 4.0 -1.1 -1.7 -2.0 -0.6
Crohns Disease (2012) 0.6 1.0 1.9 1.0 -0.1 1.1 -1.4
Mean Putamen Volume 1.8 2.0 3.6 -1.7 0.3 -1.9 -1.2
Fasting Glucose 0.4 0.5 0.9 -0.8 0.9 -0.4 -0.7
HbA1C 0.9 1.0 3.0 -0.9 -0.5 0.3 -1.7
HDL Cholesterol 1.3 2.2 4.3 -2.1 -0.4 -1.2 -1.7
LDL Cholesterol 0.4 0.6 1.3 0.8 1.1 0.5 0.3
Lupus 0.9 1.4 2.2 -1.5 -1.4 -1.0 -0.7
Neuroticism (2016) 0.9 1.2 2.4 1.1 1.5 1.0 0.6
Primary Biliary Cirrhosis 1.3 1.9 3.5 1.6 -1.9 0.6 1.1
Rheumatoid Arthritis 0.7 1.0 2.0 1.4 0.7 0.6 -1.0
Schizophrenia (2014) 1.3 2.8 5.6 2.4 1.1 2.1 0.2
Triglycerides 1.0 1.6 3.5 0.8 -1.4 0.3 1.9
Type 2 Diabetes (T2D) (2012) 1.4 1.6 5.8 0.2 -2.4 0.5 -0.4
Ulcerative Colitis 0.3 0.5 1.2 -1.1 0.2 -0.8 0.2
Blood Eosinophil Count 0.7 5.5 10.5 2.5 -3.2 0.8 2.1
Blood Platelet Count 0.1 0.6 1.0 1.0 0.3 -0.8 -0.8
Blood Red Count 1.4 13.4 27.2 3.2 5.2 3.3 2.2
Blood White Count 0.1 0.5 1.9 1.4 -0.2 0.4 -0.2
Heel T-Score 0.2 1.2 2.4 0.3 -1.5 1.5 -0.1
BMI 1.2 7.2 22.9 0.9 -4.8 -2.3 0.0
Height 0.3 5.7 9.4 -2.6 0.3 -2.6 -3.1
Waist Hip Ratio (WHR) 0.2 1.1 1.9 -0.2 -0.9 1.3 1.4
Systolic Blood Pressure 0.5 2.7 4.6 -2.0 1.2 -0.8 -2.1
Smoking Status 9.3 22.3 81.3 2.3 -9.0 -0.1 -1.5
Allergy or Eczema 0.7 1.9 5.2 2.3 -0.3 1.3 0.7
Cardiovascular Disease 0.4 1.4 2.4 1.5 -0.3 0.9 1.5
Hypothyroidism (self reported) 0.3 0.7 2.1 -0.0 1.5 0.4 0.8
Respiratory disease 0.0 0.0 0.1 0.3 -0.1 0.0 -0.2
Type 2 Diabetes (T2D) (2018) 0.8 1.5 4.4 1.2 -2.1 0.2 0.2
Lung FEV1/FVC ratio 0.2 0.8 1.2 -0.4 0.9 -1.1 -1.0
Lung FVC 0.2 0.9 2.7 -0.5 1.6 0.9 0.1
Neuroticism 1.6 3.9 9.1 3.0 1.7 1.0 1.6
Chronotype (morning person) 1.6 3.8 8.8 -3.0 2.2 -0.3 -1.1
Hair Pigment 0.1 3.7 6.4 -2.4 2.5 -1.6 -0.0
Tanning 0.3 3.1 5.4 -2.3 1.5 -1.1 -1.9
Hand grip strength (left) 1.1 2.9 7.1 1.5 2.7 1.4 0.5
Number of treatments/medications taken 2.3 4.1 6.2 2.5 -2.1 0.6 2.3
Average weekly spirits intake 0.1 0.1 0.4 -0.2 0.6 -0.2 -0.0
Sensitivity / hurt feelings 1.9 3.3 7.1 2.7 0.8 2.3 -0.1
Frequency of depressed mood in last 2 weeks 1.2 1.7 5.1 2.3 1.2 -0.1 0.6
Hearing difficulty/problems: Yes 1.2 1.9 5.2 -0.5 -0.2 -1.5 -2.3
Relative age of first facial hair 0.4 0.9 1.7 0.2 1.3 0.9 -1.0
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.3 0.9 -0.7 1.5 -0.0
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.6 1.5 -1.9 -0.5 -0.3
Ever had hysterectomy (womb removed) 1.5 1.7 3.1 1.5 -0.7 1.8 0.9
Systolic blood pressure, automated reading 1.6 4.6 7.2 -2.5 0.8 -2.1 -2.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.4 -0.5 0.1 -1.2 -0.6
Angina 0.0 0.0 0.1 -0.1 0.3 -0.1 -0.2
Medication for hormone replacement therapy 3.1 3.5 9.1 1.9 -3.0 1.0 -0.3
Vitamin and mineral supplements 0.8 1.0 3.8 0.2 0.4 0.2 1.9
Supplements: Zinc 0.7 0.8 1.9 -1.4 -0.0 -0.9 -0.7
Medication: Co-codamol 0.8 0.9 1.8 1.4 -0.6 0.7 0.9
Medication: Metformin 1.3 1.8 6.9 0.2 -2.6 -0.5 -0.0
Diabetes (father) 0.5 0.7 2.5 -1.6 0.2 -0.2 0.4
Diabetes (mother) 0.5 0.6 1.6 0.5 0.3 1.2 0.8
Severe depression (siblings) 2.9 3.3 10.0 -1.2 -0.6 -1.1 -3.2
Pack years adult smoking proportion 0.4 0.6 1.0 0.5 -1.0 1.0 0.5
Impedance of leg (right) 0.1 0.6 1.4 0.5 0.2 1.2 0.7
Leg fat-free mass (left) 0.4 2.4 3.2 -0.9 -1.8 -1.7 -1.6
Trunk fat percentage 1.4 5.8 17.6 1.4 -4.2 -1.7 0.8
Hand grip strength (right) 0.9 2.6 4.2 1.6 2.1 1.7 0.9
Townsend deprivation index at recruitment 4.2 5.9 13.0 3.6 -1.6 2.5 1.3
Current tobacco smoking 4.5 7.3 17.0 3.3 -4.1 1.2 0.1
Average weekly fortified wine intake 0.1 0.1 0.2 -0.1 -0.4 -0.4 -0.3
Maternal smoking around birth 2.8 4.0 15.2 0.4 -3.9 0.1 -0.8
Fed-up feelings 1.8 3.2 7.6 2.7 -1.5 1.6 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 3.6 1.9 0.4 0.0 0.9
Relative age voice broke 0.7 1.1 2.8 -0.4 1.1 -0.1 -1.7
Taking other prescription medications 1.5 2.4 6.0 1.6 -2.4 0.8 0.7
Age when periods started (menarche) 1.1 2.7 5.7 1.9 -0.9 0.9 2.4
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 2.3 1.5 -1.5 0.3 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.6 1.6 -0.4 -0.7 1.2 0.2
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.1 -0.9 -1.4 -1.4 -0.1
Qualifications: CSEs or equivalent 0.7 0.9 2.3 1.1 0.0 -0.2 1.5
Serious illness, injury or assault to yourself 0.9 1.1 2.1 1.4 -1.4 0.8 -0.1
High blood pressure 0.4 1.2 2.9 0.8 -0.2 1.2 1.7
Hayfever, allergic rhinitis or eczema 1.7 3.7 8.1 2.9 -0.8 2.1 1.3
Multivitamins +/- minerals 0.3 0.4 1.4 -0.1 0.2 -0.4 -1.2
Stomach or abdominal pain in last month 0.1 0.1 0.2 0.5 0.1 0.2 -0.5
Supplements: Glucosamine 1.0 1.2 3.0 -0.7 -0.5 -1.1 -1.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.3 0.5 0.3 0.3 0.6
Medication: Atenolol 0.5 0.7 2.4 -0.1 -0.3 0.5 1.5
Medication: Levothyroxine sodium 0.6 1.0 3.1 -0.3 1.8 0.5 0.8
Sitting height 0.2 1.6 3.4 -1.1 1.8 0.2 -1.3
Chronic bronchitis/emphysema (father) 1.4 1.6 4.9 -0.9 -2.2 -0.9 0.1
High blood pressure (mother) 0.9 1.2 3.0 -1.3 1.7 0.4 -0.2
Body mass index (BMI) 1.1 4.6 15.4 1.0 -3.9 -0.9 1.0
Impedance of leg (left) 0.2 0.8 1.4 0.6 0.3 1.2 1.2
Leg predicted mass (left) 0.5 2.6 3.5 -1.0 -1.9 -1.7 -1.7
Trunk fat mass 1.0 4.4 13.8 0.9 -3.7 -1.6 0.5
Waist circumference 0.8 3.1 9.7 0.6 -3.1 -0.7 1.3
Number of incorrect matches in round 0.8 1.3 2.9 1.7 0.5 0.6 1.4
Past tobacco smoking 9.1 16.7 63.9 -0.8 8.0 0.9 1.1
Alcohol usually taken with meals 1.2 1.9 4.4 -2.1 1.6 0.7 -0.4
Nervous feelings 2.1 3.9 5.6 2.1 2.4 1.0 2.1
Frequency of tenseness / restlessness in last 2 weeks 1.6 2.5 8.6 1.0 2.9 0.4 0.4
Hearing difficulty/problems with background noise 0.4 0.6 1.7 0.7 -0.1 -0.6 -1.3
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.2 -0.0 -0.0 0.5
Had menopause 0.4 0.5 1.6 0.0 -1.3 -0.7 -0.3
Had other major operations 2.5 3.1 7.0 2.6 -0.8 2.0 0.8
Forced vital capacity (FVC) 0.6 2.4 5.2 -1.6 2.3 -0.0 -1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.8 -0.3 -0.8 1.3 0.4
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 2.9 1.5 0.2 1.7 0.1
Qualifications: None of the above 0.7 1.5 1.8 1.3 -1.1 1.3 1.2
Financial difficulties in last 2 years 2.1 2.9 6.6 2.6 -1.1 1.9 -0.3
Mouth/teeth dental problems 0.2 0.3 0.7 0.3 0.5 0.2 0.8
Heart attack 0.6 0.8 1.3 -0.9 -1.2 -0.8 0.6
Allergy 0.7 1.6 4.4 -2.1 1.0 -1.1 -0.0
Pain all over the body in last month 0.6 0.7 2.7 1.6 -0.1 -0.0 0.0
Diabetes (self-reported) 0.6 0.9 1.9 1.2 -1.4 0.7 0.2
Hayfever/allergic rhinitis (self-reported) 1.0 1.4 2.7 0.6 -0.5 1.6 1.5
Medication: Ramipril 0.5 0.6 0.9 -1.0 -0.8 0.3 -0.9
Medication: Simvastatin 1.7 2.6 7.0 1.6 0.3 0.7 2.7
Fluid intelligence score 0.3 0.5 1.7 0.5 1.3 0.0 -0.4
Illnesses of siblings 0.8 1.1 1.9 -1.3 -0.9 -1.4 -0.4
Neuroticism score 2.1 4.3 12.0 3.5 1.4 1.7 0.7
Weight 0.6 3.2 9.8 -0.2 -3.1 -1.7 -0.2
Impedance of arm (right) 0.2 0.9 2.9 0.6 1.7 -0.3 -0.4
Arm fat percentage (right) 1.2 4.6 13.2 1.2 -3.6 -1.5 1.2
Trunk fat-free mass 0.3 1.7 3.7 -1.9 -0.2 -1.2 -1.4
Hip circumference 0.5 2.0 5.3 1.0 -2.3 -1.0 1.0
Time employed in main current job 0.8 0.9 1.9 0.0 1.3 1.4 0.3
Alcohol intake versus 10 years previously 4.0 6.0 10.4 3.2 -1.6 3.0 1.4
Father’s age at death 2.3 3.1 5.6 -2.4 1.5 -1.2 -1.8
Worrier / anxious feelings 4.0 7.5 14.9 2.7 3.9 1.9 2.1
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 9.6 3.1 -0.9 1.2 1.5
Falls in the last year 0.4 0.5 1.3 -0.7 -0.4 -0.2 -1.2
Hair/balding pattern: Pattern 3 0.3 0.4 1.2 -0.7 0.1 -1.1 -0.2
Number of live births 0.6 0.8 1.3 0.9 0.6 0.9 1.2
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 5.8 -1.9 2.4 -0.1 -1.4
Pulse rate 2.7 4.6 8.9 3.0 1.2 2.4 1.5
Happiness 1.0 1.2 2.1 1.5 0.7 0.6 1.4
Noisy workplace 0.5 0.6 1.7 -0.1 0.0 0.9 -1.3
Qualifications: A levels/AS levels or equivalent 1.3 2.8 6.0 -2.4 1.7 -0.0 -1.6
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.3 -0.2 1.2 1.0 0.0
Mouth/teeth dental problems: Dentures 0.4 0.7 1.2 -0.5 -1.1 -1.1 -0.6
Asthma 0.1 0.3 0.6 -0.5 -0.8 -0.4 -0.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.5 0.0 -0.7 0.7 -0.1
Medication: Cholesterol lowering 1.1 1.6 3.9 0.9 1.0 1.0 2.0
Depression (self-reported) 0.2 0.3 0.3 0.4 0.5 0.6 0.6
Medication: Lansoprazole 0.8 0.9 3.0 0.3 -1.7 0.0 -0.8
Prospective memory result 1.5 1.9 5.0 2.2 0.3 0.7 1.4
Lung cancer (father) 1.8 2.1 4.1 1.4 0.0 1.6 2.0
Illnesses of mother 1.0 1.2 2.6 0.4 -1.6 -1.1 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 3.3 -0.1 1.8 0.8 -1.6
Pulse wave Arterial Stiffness index 0.8 0.9 2.3 0.1 -0.9 -1.5 -0.7
Impedance of arm (left) 0.1 0.6 1.9 0.7 1.4 -0.3 -0.3
Arm fat mass (right) 1.0 4.3 13.2 0.5 -3.6 -1.7 0.7
Trunk predicted mass 0.3 1.6 3.3 -1.8 -0.2 -1.1 -1.3
Standing height 0.5 4.6 7.0 -2.6 1.2 -1.8 -2.6
Length of working week for main job 1.1 1.2 1.7 -0.8 -1.3 -1.1 -1.2
Exposure to tobacco smoke at home 0.9 1.0 3.1 0.6 -1.8 0.4 0.5
Breastfed as a baby 0.4 0.5 1.1 0.8 0.5 0.4 1.0
Tense / ‘highly strung’ 0.5 0.8 2.8 -0.0 1.7 -0.5 -0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.7 0.5 -1.3 -0.5 -1.0
Hair/balding pattern: Pattern 4 0.2 0.5 1.4 0.5 -0.3 -0.4 -1.2
Birth weight of first child 0.6 1.0 2.7 -1.1 0.5 -1.7 0.1
Peak expiratory flow (PEF) 1.2 2.7 4.0 -2.0 1.3 -1.2 -2.0
Pulse wave reflection index 1.9 2.3 5.6 -0.8 -2.4 -1.5 -1.0
Ever highly irritable/argumentative for 2 days 2.6 3.1 5.4 2.1 1.0 2.3 1.2
Loud music exposure frequency 1.1 1.2 3.6 -1.9 0.3 0.4 -0.9
Qualifications: O levels/GCSEs or equivalent 1.0 1.7 4.2 -1.2 2.1 0.3 -0.9
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.7 0.6 -1.6 -1.1 0.3
Blood clot in the leg (DVT) 0.9 1.1 2.3 -0.2 -1.2 -1.5 -0.8
Medication: Paracetamol 0.5 0.8 1.7 0.1 -1.2 -0.6 -1.3
Headache pain in last month 1.2 2.0 4.6 2.1 -1.4 0.7 -1.0
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 0.9 -0.8 -1.0 -0.9 -0.6
Glaucoma (self-reported) 0.7 0.8 1.7 -1.1 0.5 -1.3 -0.0
Gout (self-reported) 0.4 0.6 1.2 -0.4 -0.9 -1.1 0.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.5 -0.0 1.2 0.1 1.2
Medication: Amlodipine 1.6 2.2 3.9 1.7 0.3 1.4 2.0
Medication: Ventolin 100micrograms inhaler 1.3 1.6 2.9 -1.7 -0.3 -1.1 -1.5
Birth weight 3.3 7.2 11.8 -3.4 1.6 -2.7 -2.7
Chronic bronchitis/emphysema (mother) 0.7 0.9 2.4 0.8 -0.6 1.6 0.3
High blood pressure (siblings) 0.5 0.8 1.4 0.9 1.2 0.8 -0.3
Forced vital capacity (FVC), Best measure 0.3 1.2 2.3 -0.4 1.5 0.4 -1.4
Body fat percentage 1.5 6.1 17.8 1.5 -4.2 -1.5 1.4
Leg fat percentage (right) 1.9 6.9 20.2 1.6 -4.5 -0.5 2.1
Arm fat-free mass (right) 0.3 1.7 3.3 -1.2 -1.8 -1.1 -0.9
Exposure to tobacco smoke outside home 1.4 1.8 3.6 0.4 -0.6 1.9 -1.8
Comparative body size at age 10 1.4 3.8 6.5 -1.4 -2.0 -2.5 -1.7
Number of full brothers 3.9 4.9 8.4 2.1 -2.5 1.0 2.9
Worry too long after embarrassment 2.1 3.4 7.3 2.7 2.1 1.4 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.5 1.9 4.7 2.2 0.2 1.6 0.4
Wheeze or whistling in the chest in last year 0.8 1.3 3.7 -0.3 -1.0 -0.8 -1.9
Number of children fathered 0.6 0.7 2.4 -0.2 1.6 -0.4 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.9 2.2 3.9 0.6 2.0 1.1 -1.9
Age at first live birth 1.7 3.0 5.4 -1.8 2.3 -1.6 -1.1
Pulse wave peak to peak time 0.7 0.9 1.9 -0.1 1.1 1.4 0.6
Health satisfaction 0.3 0.4 1.1 0.1 -1.0 -0.3 0.6
Shortness of breath walking on level ground 1.0 1.2 4.4 2.1 0.6 0.3 0.3
Qualifications: College or University degree 1.9 6.1 11.3 -3.0 0.8 -1.8 -3.4
Eye problems/disorders: None of the above 0.9 1.1 2.9 0.0 1.7 0.7 -1.0
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.6 0.5 0.2 0.8 -0.6
Emphysema/chronic bronchitis 0.6 0.7 2.0 0.7 0.2 0.4 -1.4
Medication for pain relief, constipation, heartburn 1.6 2.6 10.2 -0.6 3.2 -0.2 -0.0
Neck or shoulder pain in last month 0.5 0.7 2.0 1.4 0.1 0.5 -0.8
Medication: Blood pressure 0.1 0.1 0.2 0.3 0.4 0.5 -0.1
Angina (self-reported) 0.0 0.0 0.1 -0.1 0.1 -0.3 -0.1
Migraine (self-reported) 0.5 0.6 1.9 -0.4 -1.4 0.5 -0.2
Medication: Ibuprofen 0.2 0.2 0.5 -0.4 -0.7 0.1 -0.4
Medication: Allopurinol 0.2 0.3 0.6 -0.2 -0.7 -0.2 0.7
Medication: Omeprazole 1.0 1.2 4.3 0.5 -2.1 -0.5 -0.2
Medication: Seretide 50 evohaler 1.7 2.0 3.8 -1.3 -0.3 -1.5 -2.0
Mean time to correctly identify matches 0.6 1.1 2.2 -1.4 0.4 -1.5 -0.3
Heart disease (mother) 0.5 0.7 1.4 -0.8 0.7 -0.4 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.8 -0.6 -0.9 0.4 0.5
Whole body fat mass 1.2 5.2 17.1 0.8 -4.1 -1.6 0.6
Leg fat mass (right) 1.4 5.5 19.2 0.5 -4.4 -1.4 0.8
Arm predicted mass (right) 0.3 1.5 2.7 -1.2 -1.6 -1.0 -0.9
Pulse rate, automated reading 0.9 2.8 7.1 2.7 1.4 1.0 1.2
Alcohol intake frequency. 0.9 2.1 2.9 1.7 -1.1 1.3 1.7
Comparative height size at age 10 0.4 2.1 4.7 -2.2 0.5 -1.5 -1.1
Number of full sisters 1.5 1.8 2.9 1.3 -1.1 1.7 1.2
Suffer from ‘nerves’ 1.3 2.0 5.5 1.5 2.4 0.3 -0.2
Overall health rating 2.2 4.7 11.2 3.4 -1.6 1.6 1.6
Chest pain or discomfort 0.6 0.9 1.6 0.8 -0.8 0.7 -1.3
Had major operations 0.4 0.5 0.9 0.9 0.3 1.0 -0.4
Age at last live birth 1.6 2.3 3.5 -1.6 1.9 -1.4 -1.1
Family relationship satisfaction 0.2 0.2 0.6 0.5 -0.4 -0.8 -0.1
Leg pain on walking 0.3 0.4 1.4 0.2 -0.0 0.4 -1.2
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.0 1.0 -0.4 -0.1 0.8
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.4 0.9 0.1 1.5 -0.3
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 2.9 -1.5 1.6 -1.7 1.1
Medication: Aspirin 1.6 2.1 4.5 0.8 -1.5 1.1 2.1
Supplements: Vitamin C 0.6 0.7 1.7 -1.3 -0.1 -0.2 -1.0
Knee pain experienced in last month 0.3 0.5 1.2 0.8 -0.1 1.1 -0.3
Hypertension (Self-reported) 0.5 1.3 3.2 0.9 0.1 1.0 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 1.0 2.7 0.3 -1.6 -0.1 -1.1
Illnesses of father: Heart disease 0.1 0.2 0.4 -0.1 -0.4 -0.7 0.3
Illnesses of siblings: Diabetes 0.1 0.2 0.6 0.7 -0.3 -0.0 0.2
Smoking status: Previous 6.6 9.9 37.5 -0.0 -6.1 -1.3 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.3 2.7 -0.9 0.5 -1.2 -1.6
Whole body fat-free mass 0.3 2.0 2.5 -1.6 -1.0 -1.5 -1.5
Leg fat-free mass (right) 0.4 1.9 2.6 -0.8 -1.5 -1.6 -1.5
Arm fat percentage (left) 1.3 5.1 15.2 1.2 -3.9 -1.4 1.3
Average weekly red wine intake 1.9 2.8 6.8 -0.7 2.6 0.6 -1.9
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.4 -0.2 -0.6 -0.4 0.4
Mood swings 0.3 0.6 1.5 1.2 -0.5 0.6 0.4
Loneliness, isolation 0.9 1.2 1.9 1.3 1.4 -1.0 -0.0
Long-standing illness, disability or infirmity 3.2 4.9 15.2 1.7 -3.9 0.9 0.7
Ever had bowel cancer screening 1.0 1.1 2.1 1.4 -0.6 -1.2 0.9
Diabetes diagnosed by doctor 1.3 2.2 4.4 1.8 -2.1 0.8 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 3.0 1.7 0.1 -0.1 -0.1
Friendships satisfaction 0.3 0.3 1.1 0.3 1.1 -0.2 0.0
Qualifications: nursing, teaching 0.9 1.3 2.5 -1.6 0.8 -0.5 -1.4
Commuting to job workplace: Walk 0.4 0.4 0.8 -0.9 0.9 -0.5 0.2
Eye problems/disorders: Cataract 0.1 0.2 0.6 0.1 -0.7 -0.3 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.8 -0.9 -0.5 0.7 -0.0
Medication for cholesterol 2.4 3.6 6.0 -2.2 2.5 -0.6 -1.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.8 -0.4 0.0 0.7 -1.3
Back pain experienced in last month 2.7 4.0 10.0 3.2 -1.1 1.8 1.2
Mineral and other dietary supplements 2.9 4.0 5.8 2.0 1.1 2.1 2.4
Breast cancer (self-reported) 0.0 0.1 0.2 -0.2 0.0 0.0 -0.4
Asthma (self-reported) 0.1 0.3 0.6 -0.5 -0.8 -0.5 0.1
Osteoporosis (self-reported) 1.5 1.8 3.8 1.0 1.9 1.6 -0.3
Osteoarthritis (self-reported) 0.7 0.9 2.3 0.6 -1.0 -0.1 -1.5
Medication: Aspirin 1.9 2.5 6.2 1.1 -0.7 1.4 2.5
Medication: Gliclazide 0.8 1.0 3.0 0.5 -1.7 -0.6 0.3
Illnesses of father: None of the above (group 1) 0.5 0.7 1.7 -0.6 0.8 -0.2 -1.3
Smoking status: Current 4.3 6.8 16.0 3.2 -4.0 1.0 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 0.5 0.2 0.6 0.2
Whole body water mass 0.3 1.7 2.0 -1.4 -1.0 -1.4 -1.3
Leg predicted mass (right) 0.4 1.9 2.4 -0.8 -1.5 -1.5 -1.5
Arm fat mass (left) 1.1 4.7 14.9 0.8 -3.9 -1.6 0.8
Number of self-reported non-cancer illnesses 2.0 3.4 6.4 2.2 -2.5 1.6 0.5
Average weekly champagne plus white wine intake 1.8 2.4 5.3 -2.3 1.2 -0.3 -1.7
Miserableness 0.9 1.5 2.8 1.7 -1.0 0.4 -1.4
Guilty feelings 2.1 3.1 4.4 1.8 2.0 0.9 2.1
Wears glasses or contact lenses 0.5 0.6 1.3 0.6 -1.2 0.3 -0.7
Ever taken oral contraceptive pill 1.6 1.7 3.8 1.0 -1.2 0.8 -2.0
Hearing aid user 0.3 0.3 0.5 0.0 -0.6 -0.7 -0.7
Mother’s age at death 0.4 0.5 1.2 -0.6 1.1 -0.6 0.0
Financial situation satisfaction 0.8 1.0 1.9 1.2 1.4 0.4 0.8
Tinnitus: Yes, now most or all of the time 1.3 1.5 3.3 -1.5 -0.6 -0.5 -1.8
Commuting to job workplace: Public transport 0.8 0.9 2.0 -1.4 0.8 -0.1 -1.0
Eye problems/disorders: Glaucoma 0.1 0.1 0.4 -0.1 0.0 -0.7 0.0
Medication: Blood pressure 1.3 2.4 4.3 2.0 -1.1 0.7 2.1
Pain type(s) experienced in last month: Hip pain 1.2 1.5 3.9 -0.2 -2.0 -0.3 -1.3
Supplements: Fish oil (including cod liver oil) 1.2 1.6 2.4 -1.3 -0.8 -1.2 -1.6
High cholesterol (Self-reported) 2.4 4.2 8.5 2.2 1.0 1.6 2.9
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.4 -0.2 -0.4 -0.1
Medication: Paracetamol 1.1 1.7 2.8 -0.7 -1.3 -1.3 -1.7
Medication: Lisinopril 0.7 0.9 2.2 0.4 0.9 1.5 0.8
Medication: Atorvastatin 0.3 0.4 1.2 0.0 -0.4 0.4 1.1
Illnesses of father: High blood pressure 1.0 1.2 2.9 0.6 1.7 1.1 0.5
Alcohol drinker status: Never 0.2 0.2 0.7 -0.0 -0.8 0.4 0.1
Ever smoked 6.6 11.6 45.4 0.4 -6.7 -0.4 -0.7
Basal metabolic rate 0.3 1.9 3.0 -1.1 -1.7 -1.5 -1.1
Leg fat percentage (left) 1.9 7.0 19.5 1.6 -4.4 -0.6 2.4
Arm fat-free mass (left) 0.2 1.2 2.3 -1.0 -1.5 -1.1 -0.6
Number of operations (self-reported) 1.3 1.9 3.2 1.8 -1.1 1.8 0.4
Average weekly beer plus cider intake 4.8 7.0 11.7 3.4 -2.5 1.7 2.7
Irritability 0.4 0.7 1.6 1.3 -0.7 -0.0 0.8
Risk taking 2.8 4.1 6.2 -2.5 -1.6 -1.1 -2.5
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.6 -0.6 -0.3 0.8 0.4
Fractured/broken bones in last 5 years 1.7 2.2 4.4 -1.0 -0.6 -1.7 -2.1
Age started oral contraceptive pill 2.7 3.3 7.1 -1.5 2.7 -1.8 -0.9
Diastolic blood pressure, automated reading 0.8 2.4 4.2 -1.6 1.6 -0.7 -2.0
Ever depressed for a whole week 0.4 0.5 1.0 0.7 -0.8 1.0 0.1
Unable to work because of sickness or disability 0.4 0.5 1.5 -0.2 -1.2 -0.5 -0.4
Commuting to job workplace: Cycle 1.2 1.5 5.7 -0.1 2.4 -0.5 0.1
Myopia 0.7 1.0 3.5 -1.9 -0.6 -0.5 -0.3
Vascular/heart problems diagnosed by doctor 0.5 1.5 3.6 -0.6 0.7 -1.2 -1.9
Cholesterol lowering medication 1.4 2.0 4.2 1.6 -1.1 0.3 2.1
Medication: Omeprazole (e.g. Zanprol) 0.8 0.9 3.4 0.5 -1.8 -0.1 -0.0
Pain experienced in last month 1.2 2.1 4.2 -1.6 2.0 -0.5 1.1
Supplements: Calcium 0.1 0.1 0.2 0.5 -0.0 -0.4 -0.1
Basal cell carcinoma (self-reported) 0.4 0.4 0.9 -0.9 0.0 -0.0 -0.9
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.1 -0.7 -0.9 -0.6 1.0
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.2 -0.1 -1.3 -1.5 -0.8
Heart disease (siblings) 0.3 0.3 0.9 0.6 -0.0 0.9 0.1
Alcohol drinker status: Previous 1.2 1.4 4.1 1.0 -2.0 0.2 0.7
Pack years of smoking 0.2 0.3 0.9 0.3 -0.4 0.9 0.3
Impedance of whole body 0.1 0.5 0.9 0.8 0.9 0.4 0.4
Leg fat mass (left) 1.4 5.5 18.6 0.5 -4.3 -1.5 0.9
Arm predicted mass (left) 0.3 1.6 3.7 -1.0 -1.9 -1.2 -0.6