TWAS hub - PIP4K2C

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue (Male)	0.0725	0.0879	0.2400	-0.012	NA	-0.006	NA	-0.010	0.8100	NA	0.4800	NA	0.650
2	GTEx	Breast Mammary Tissue (Female)	0.0196	0.0413	0.3500	-0.008	NA	-0.007	NA	0.012	0.6900	NA	0.6100	NA	0.140
3	GTEx	Spleen	0.3150	0.1310	0.0049	0.079	NA	0.030	NA	0.062	0.0046	NA	0.0570	NA	0.011
4	YFS	Blood	0.0150	0.0072	0.0029	0.000	0.010	0.003	0.009	0.002	0.3000	0.00025	0.0420	0.00037	0.054
5	TCGA	Brain Lower Grade Glioma	0.0410	0.0209	0.0023	0.002	0.014	0.018	NA	0.012	0.1700	0.00790	0.0038	NA	0.014

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Severe depression (siblings)	5.3	5.9	8.0	2.1	2.7	2.8	2.3	2.1
Rheumatoid Arthritis	5.0	6.8	12.5	-2.0	3.0	3.5	2.9	0.7
Ulcerative Colitis	5.0	7.2	11.5	2.6	3.4	2.6	2.7	1.9
Exposure to tobacco smoke outside home	4.3	5.7	10.5	-2.0	-3.2	-3.2	-1.8	-0.8
Blood Platelet Count	4.1	47.3	88.4	-6.3	-8.4	-9.4	-4.7	-3.9
Schizophrenia vs Biploar Disorder	3.8	5.1	8.6	0.7	2.9	2.8	2.9	-0.6
Sensitivity / hurt feelings	3.7	6.3	11.7	2.8	3.2	3.4	0.5	1.2
Impedance of arm (right)	3.5	16.2	38.7	1.9	5.7	6.2	2.4	-0.2
Worry (Nagel 2018)	3.3	7.0	12.8	3.1	3.6	3.3	-0.2	1.2
Sitting height	3.3	23.2	72.8	1.3	6.4	8.5	0.4	0.1
Medication: Seretide 50 evohaler	3.3	3.8	9.8	-0.7	2.4	1.6	3.1	0.5
Frequency of depressed mood in last 2 weeks	3.2	4.5	6.9	-1.7	1.3	2.2	2.5	2.6
Chronotype (morning person)	3.1	7.1	13.5	-3.0	-3.4	-3.7	-0.6	-1.1
Medication: Levothyroxine sodium	3.1	5.2	15.8	-0.4	2.3	4.0	2.2	0.2
Irritable Bowel Disease (IBD)	2.9	6.9	11.0	1.9	2.9	3.3	2.8	1.9
Impedance of arm (left)	2.9	13.5	31.2	1.9	5.3	5.6	2.2	-0.0
Average weekly champagne plus white wine intake	2.9	4.0	8.2	1.6	1.9	2.9	2.3	-0.5
Commuting to job workplace: Public transport	2.9	3.5	7.3	1.5	1.9	2.7	1.5	-1.4
Depression (Nagel 2018)	2.8	4.3	9.4	-1.2	1.0	2.6	3.1	1.7
Hypothyroidism (self reported)	2.8	6.3	15.5	-0.4	2.4	3.9	3.0	0.9
Tense / ‘highly strung’	2.8	4.6	7.1	2.6	2.4	1.8	-0.5	2.7
Gout (self-reported)	2.8	3.9	7.8	-2.7	-0.9	-0.9	-1.7	-2.8
Medication: Allopurinol	2.7	3.6	6.3	-1.6	-1.8	-1.3	-2.1	-2.5
Body Mass Index (BMI) (2010)	2.6	3.6	6.0	1.2	2.3	2.0	1.2	2.4
Primary Biliary Cirrhosis	2.6	3.7	10.1	0.7	3.2	2.7	0.5	-0.5
High blood pressure (siblings)	2.6	3.7	7.2	1.6	2.7	2.7	-1.3	-0.2
Impedance of whole body	2.6	13.3	30.9	1.8	5.2	5.6	2.3	-0.4
Ulcerative Colitis (UC)	2.5	4.7	8.0	1.3	2.2	2.1	2.8	2.1
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	12.6	-1.3	0.9	1.5	1.7	3.5
Allergy	2.4	5.4	19.1	0.9	-1.3	-1.3	-2.0	-4.4
Commuting to job workplace: Cycle	2.4	2.9	7.8	-1.4	-1.3	-1.7	-0.5	-2.8
Verbal and Numeric Reasoning (VNR)	2.3	5.6	14.7	-0.7	2.3	3.8	1.3	-2.5
Bipolar Disorder (2011)	2.3	2.2	6.2	2.5	-1.3	-1.3	-1.3	0.0
Alcohol intake versus 10 years previously	2.3	3.4	4.7	-2.1	-2.1	-2.2	-1.9	-0.1
Worrier / anxious feelings	2.3	4.3	7.8	2.4	2.8	2.8	-0.4	-0.5
Hypothyroidism/myxoedema (self-reported)	2.3	4.4	11.6	-0.4	1.8	3.4	2.5	1.0
Smoking status: Previous	2.3	3.4	7.3	2.7	1.4	1.4	-2.2	1.0
Illnesses of father: None of the above (group 1)	2.3	2.8	6.7	-2.6	-1.0	-0.7	2.3	0.7
Fasting Glucose	2.2	2.6	6.8	2.6	2.0	1.5	-0.2	0.0
Height	2.2	41.6	125.2	4.0	8.1	11.2	-1.0	0.7
Medication: Atenolol	2.2	2.8	4.7	-1.6	-2.2	-2.2	-0.7	-1.2
Nervous feelings	2.2	4.2	6.3	2.5	2.5	2.1	-1.1	1.6
Pulse wave Arterial Stiffness index	2.2	2.6	7.6	2.8	0.2	2.1	-0.4	-0.8
Past tobacco smoking	2.1	3.8	10.7	-2.1	-0.5	0.3	3.3	-1.8
Financial difficulties in last 2 years	2.1	2.8	8.1	-2.8	-1.0	-1.9	0.8	1.0
Fluid intelligence score	2.1	4.3	12.7	0.5	2.1	3.6	1.6	-1.2
Asthma	2.1	4.1	11.1	-0.4	0.6	1.2	2.7	3.3
Standing height	2.1	20.6	50.6	3.7	5.9	7.1	-1.6	1.2
Supplements: Fish oil (including cod liver oil)	2.1	2.8	6.5	-2.1	-1.0	-0.4	-1.4	-2.5
Cholesterol lowering medication	2.1	3.1	5.1	-2.3	-2.0	-0.7	-0.7	-2.3
Major Depression (MDD)	2.0	2.5	3.5	1.9	1.9	1.6	0.2	1.7
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	5.4	0.1	1.6	1.9	0.9	2.3
Angina	1.9	2.4	5.5	-0.4	-1.6	-2.3	-1.9	0.5
Number of incorrect matches in round	1.9	3.1	9.2	2.0	3.0	1.3	-0.1	0.8
Heart attack	1.9	2.4	6.4	-2.5	-1.3	-1.2	-0.9	-1.3
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	6.6	0.3	2.6	2.0	0.8	1.2
Noisy workplace	1.9	2.4	8.6	-0.7	-1.5	-2.9	-0.6	0.1
Depression (self-reported)	1.9	2.3	6.8	0.6	2.6	1.8	0.8	0.6
Angina (self-reported)	1.9	2.4	5.2	-0.5	-1.6	-2.3	-2.0	0.6
Risk taking	1.9	2.8	4.9	-0.0	-2.2	-2.0	-2.1	-0.7
Average weekly spirits intake	1.8	2.2	6.7	-1.2	-1.5	-2.6	-0.9	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	6.6	1.6	1.2	2.6	1.0	-0.2
Leg pain on walking	1.8	2.3	6.1	-0.3	1.2	1.4	1.3	2.5
Asthma (self-reported)	1.8	3.5	9.0	-0.1	0.6	1.0	2.7	3.0
Illnesses of father: High blood pressure	1.8	2.2	3.1	1.4	1.2	1.3	-1.7	-1.8
Ever had prostate specific antigen (PSA) test	1.8	2.1	6.6	-1.1	0.4	0.3	2.6	-1.7
Ovarian Cancer	1.7	2.2	4.4	-2.0	-1.4	-2.1	-0.8	-0.2
Relative age of first facial hair	1.7	3.5	6.7	-0.0	-2.3	-2.6	-2.2	-0.8
Current tobacco smoking	1.7	2.8	8.5	-1.6	-0.8	-1.5	0.1	2.9
Illnesses of siblings	1.7	2.3	6.0	-1.4	-2.5	-1.6	1.0	-0.1
Medication: Lansoprazole	1.7	1.9	5.9	2.4	1.6	0.9	-0.3	-0.5
Length of working week for main job	1.7	1.9	4.2	-1.4	-2.1	-1.6	0.6	-0.5
Pulse wave peak to peak time	1.7	2.0	6.4	-2.5	0.3	-1.7	0.3	0.7
Suffer from ‘nerves’	1.7	2.6	5.6	2.4	1.8	1.8	0.0	1.0
Long-standing illness, disability or infirmity	1.7	2.7	4.4	0.3	2.1	1.5	2.1	1.6
Medication: Gliclazide	1.7	1.9	6.2	-0.2	-0.6	-1.4	-2.5	-1.1
High cholesterol (Self-reported)	1.7	2.9	3.8	-1.9	-1.0	-1.6	-1.9	-1.9
Medication: Lisinopril	1.7	2.2	4.0	0.1	-1.3	-1.8	-2.0	-1.3
Intelligence (Savage-Jansen 2018)	1.6	4.8	15.7	-0.1	1.4	4.0	0.6	-2.5
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	4.1	1.7	1.4	-0.1	-0.5	2.0
Illnesses of siblings: Diabetes	1.6	1.9	4.3	2.1	1.6	1.2	-0.9	0.8
Friendships satisfaction	1.6	1.9	5.7	-1.6	-0.2	0.5	2.4	1.1
Eye problems/disorders: Cataract	1.6	1.9	5.6	0.6	1.3	2.4	-0.2	-1.3
Medication for cholesterol	1.6	2.4	6.8	2.6	1.8	0.5	1.4	0.3
Smoking status: Current	1.6	2.5	6.2	-1.5	-0.9	-1.8	-0.3	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.5	7.8	0.5	-1.2	-2.8	-2.3	1.5
Medication: Blood pressure	1.6	3.0	5.9	-1.6	-2.4	-1.7	-1.8	0.3
Bipolar Disorder (2018)	1.5	2.4	5.3	1.9	-0.0	-0.8	-2.3	1.5
Crohns Disease (2012)	1.5	2.4	6.9	0.7	2.1	2.6	0.4	0.3
Smoking Status	1.5	3.7	13.7	0.9	1.0	-0.0	-1.7	3.7
Cardiovascular Disease	1.5	4.9	8.9	-0.2	-2.5	-2.8	-3.0	-1.2
Forced vital capacity (FVC)	1.5	6.0	10.2	2.8	2.5	0.8	-3.2	2.1
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	8.3	0.6	0.1	-0.7	-2.9	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.4	4.4	1.4	2.1	1.6	0.1	1.7
Comparative body size at age 10	1.5	4.1	9.4	-0.3	-2.5	-3.1	-0.6	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	5.2	0.1	-1.3	-2.3	-1.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.0	-2.0	0.1	0.1	1.5	1.8
Hayfever, allergic rhinitis or eczema	1.4	3.0	8.4	-1.0	0.9	1.4	1.7	2.9
Mouth/teeth dental problems	1.4	2.1	9.0	-1.2	-0.1	0.3	3.0	-0.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.7	12.0	2.7	1.4	-0.3	-3.5	1.5
Medication for pain relief, constipation, heartburn	1.4	2.4	7.3	2.7	0.9	1.1	1.4	-0.9
Medication: Blood pressure	1.4	2.6	8.5	-0.1	-0.5	-1.8	-0.9	-2.9
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	2.9	1.7	1.3	0.9	-1.2	-1.3
Hypertension (Self-reported)	1.4	4.0	8.4	0.2	-1.4	-2.2	-2.9	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.7	-1.0	1.1	0.7	1.4	1.6
Qualifications: nursing, teaching	1.4	2.2	6.2	2.5	1.4	0.8	-1.4	-0.4
Wears glasses or contact lenses	1.4	1.6	4.0	2.0	0.4	-0.4	-0.9	1.7
Ever smoked	1.4	2.5	8.6	1.4	0.0	-0.5	-2.9	1.2
Unable to work because of sickness or disability	1.4	1.8	6.2	0.2	0.5	1.0	1.1	2.5
Myopia	1.4	2.1	4.6	1.2	2.1	1.7	1.2	-0.1
Vascular/heart problems diagnosed by doctor	1.4	3.8	6.1	0.8	1.6	2.5	2.4	2.0
Heart attack/myocardial infarction (self-reported)	1.4	1.8	5.0	-2.2	-1.1	-1.0	-0.7	-1.3
Respiratory disease	1.3	3.0	5.6	0.7	1.3	1.3	2.3	2.4
Neuroticism	1.3	3.2	6.5	2.0	2.6	2.2	0.3	0.7
Systolic blood pressure, automated reading	1.3	3.7	16.0	-1.0	0.3	1.1	0.3	-4.0
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	4.6	0.8	0.3	-0.7	-2.1	1.1
Vitamin and mineral supplements	1.3	1.8	5.4	0.9	0.7	-0.3	2.3	1.5
Pack years adult smoking proportion	1.3	2.0	5.8	-2.4	-1.3	-1.6	-0.1	0.2
High blood pressure (mother)	1.3	1.8	5.8	-1.1	0.8	0.9	-0.9	-2.4
Medication: Simvastatin	1.3	1.9	3.1	-1.8	-1.2	-1.2	-1.7	-0.8
Pulse rate	1.3	2.2	4.5	-0.8	-0.9	-1.9	-1.1	2.1
Forced vital capacity (FVC), Best measure	1.3	4.8	8.4	2.9	2.4	1.1	-2.7	1.1
Wheeze or whistling in the chest in last year	1.3	2.4	3.8	-1.0	-1.9	-1.6	-1.0	1.9
Loneliness, isolation	1.3	1.8	3.8	-1.9	-1.4	-0.0	0.9	-1.6
Ever taken oral contraceptive pill	1.3	1.4	2.3	1.4	1.2	1.5	0.5	1.0
Financial situation satisfaction	1.3	1.7	4.0	-2.0	-0.8	-0.8	1.7	-0.4
Medication: Atorvastatin	1.3	1.6	5.8	-2.4	-0.4	-0.3	1.2	-0.6
Crohns Disease (2017)	1.2	2.7	6.9	1.8	1.7	2.6	0.7	0.4
HbA1C	1.2	1.4	3.6	1.1	1.0	1.9	0.5	0.9
High blood pressure	1.2	3.2	6.2	0.0	-1.2	-2.3	-2.5	-1.8
Multivitamins +/- minerals	1.2	1.6	3.7	-1.2	-0.8	0.1	-1.9	-1.4
Father’s age at death	1.2	1.7	4.0	0.4	1.1	1.6	0.5	2.0
Pulse wave reflection index	1.2	1.5	4.2	1.2	0.4	2.0	-0.1	-1.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.7	1.6	0.4	-0.2	-2.2	0.6
Birth weight	1.2	2.5	5.2	2.3	1.7	1.2	-1.3	1.3
Medication: Omeprazole	1.2	1.4	2.9	0.1	1.6	0.9	0.8	1.7
Age at last live birth	1.2	1.7	7.4	-0.4	-0.2	0.9	-0.2	-2.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	4.3	-2.1	-0.2	-0.8	0.5	-1.5
Medication: Aspirin	1.2	1.6	3.0	-1.7	-1.7	-1.2	-0.6	0.4
Mineral and other dietary supplements	1.2	1.6	4.9	1.0	0.4	-0.6	1.3	2.2
Hearing aid user	1.2	1.3	3.3	0.3	0.9	1.2	1.8	1.1
Pain type(s) experienced in last month: Hip pain	1.2	1.5	6.2	-0.3	0.7	-0.6	0.6	2.5
Number of operations (self-reported)	1.2	1.7	4.6	-1.5	0.7	2.1	1.1	-0.0
Age started oral contraceptive pill	1.2	1.5	5.2	1.3	-0.1	-0.2	-2.3	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	6.0	-0.9	0.6	0.3	0.5	2.5
Pack years of smoking	1.2	1.7	4.2	-2.1	-1.2	-1.7	-0.3	-0.1
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.1	1.8	1.6	0.8	-0.5	0.4
Taking other prescription medications	1.1	1.7	3.5	1.9	0.8	-0.0	-1.3	1.7
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.3	-2.1	-0.9	0.0	-0.1	-0.9
Impedance of leg (left)	1.1	5.5	10.9	2.0	3.2	3.3	1.4	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	7.3	-0.8	0.5	0.8	0.3	2.7
Happiness	1.1	1.4	3.4	-1.8	0.1	0.1	1.8	0.3
Prospective memory result	1.1	1.3	3.5	-0.3	-1.9	-1.7	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	8.7	2.3	1.3	-0.1	-2.9	1.2
Loud music exposure frequency	1.1	1.2	5.2	-0.5	-0.5	0.3	2.3	-0.3
Qualifications: College or University degree	1.1	3.3	7.3	0.9	2.1	2.7	1.7	-1.0
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.2	0.7	0.1	-0.3	-2.1	1.4
Knee pain experienced in last month	1.1	1.7	4.6	-2.2	-0.6	-1.5	0.8	0.9
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	7.5	0.8	0.8	-0.2	-2.7	0.3
Irritability	1.1	1.8	5.2	-0.1	-1.0	-1.2	-1.3	2.3
Neuroticism (Nagel 2018)	1.0	2.3	4.4	1.3	2.1	2.1	0.8	0.8
Alzheimer’s Disease (in father)	1.0	1.0	2.3	1.1	0.3	-0.4	-1.2	1.5
Reaction Time	1.0	1.9	7.8	-0.2	-0.6	-0.2	-1.0	2.8
Age at First Birth	1.0	1.4	3.7	1.7	-0.2	0.6	-1.9	-0.3
Coronary Artery Disease (CAD)	1.0	1.2	4.3	1.2	-0.0	0.4	-0.4	2.1
Blood Red Count	1.0	9.4	26.2	3.4	2.0	5.1	1.3	-1.9
Allergy or Eczema	1.0	2.6	10.2	-0.2	0.9	1.3	0.2	3.2
Impedance of leg (right)	1.0	5.1	11.9	0.8	3.0	3.5	1.8	-0.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	2.6	-0.3	0.9	1.6	-0.9	1.2
Body mass index (BMI)	1.0	4.4	9.1	-0.4	-2.5	-3.0	-2.4	-0.7
Qualifications: None of the above	1.0	2.2	5.0	-1.4	-1.5	-2.2	-1.2	0.5
Neuroticism score	1.0	2.1	3.4	1.1	1.8	1.8	0.4	1.7
Age at first live birth	1.0	1.8	5.7	0.2	0.8	2.4	0.6	-1.5
Family relationship satisfaction	1.0	1.2	2.8	-1.1	-1.0	-0.4	1.7	-0.9
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.8	0.4	1.3	0.1	1.9	-0.2
Fractured/broken bones in last 5 years	1.0	1.2	5.0	0.7	0.5	-0.8	-0.0	2.2
BMI	0.9	5.2	13.7	0.7	-2.3	-3.7	-2.6	0.0
Lung FEV1/FVC ratio	0.9	4.7	8.0	0.8	-2.7	-2.8	-2.0	2.0
Lung FVC	0.9	4.7	10.4	0.5	-0.5	-2.7	-3.2	2.2
Diabetes (father)	0.9	1.1	2.5	-0.6	0.8	1.3	-0.3	1.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.4	-0.9	-1.3	-1.5	-0.3	-0.6
Serious illness, injury or assault to yourself	0.9	1.1	2.6	-0.2	-0.8	1.6	1.4	0.4
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.9	0.6	1.7	2.2	0.8	-1.1
Glaucoma (self-reported)	0.9	1.0	2.2	0.8	1.5	0.8	0.9	-0.9
Overall health rating	0.9	2.0	8.9	-0.9	-0.3	0.1	0.5	3.0
Illnesses of father: Heart disease	0.9	1.3	3.4	0.5	-0.2	-1.3	-1.9	-0.9
Number of self-reported non-cancer illnesses	0.9	1.5	2.5	-0.9	1.6	1.6	1.2	0.3
Type 2 Diabetes (T2D) (2012)	0.8	1.0	2.0	1.4	0.3	-0.1	-1.3	-1.0
Waist Hip Ratio (WHR)	0.8	3.7	6.5	0.8	2.5	2.4	-2.2	0.7
Systolic Blood Pressure	0.8	4.0	17.2	-0.3	-0.8	-0.4	-1.2	-4.2
Hearing difficulty/problems: Yes	0.8	1.2	3.5	-0.1	1.0	1.2	1.9	0.4
Trunk fat percentage	0.8	3.1	4.3	2.0	2.0	1.5	-2.1	-1.1
Hand grip strength (right)	0.8	2.2	5.8	0.9	0.9	1.4	-1.2	-2.4
Fed-up feelings	0.8	1.4	2.4	-1.5	0.2	0.5	1.5	1.4
Waist circumference	0.8	2.9	11.7	1.5	0.4	-0.1	-3.4	-0.3
Hearing difficulty/problems with background noise	0.8	1.2	2.6	-0.3	1.0	0.6	1.6	1.4
Had menopause	0.8	1.0	2.0	0.5	1.4	1.1	0.9	0.9
Medication: Cholesterol lowering	0.8	1.3	3.5	-1.9	-0.1	-1.4	-0.3	-0.8
Lung cancer (father)	0.8	0.9	1.9	-0.2	-0.4	-1.3	-1.4	-0.8
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.4	-0.7	-0.7	-0.7	1.8	0.5
Medication: Ibuprofen	0.8	1.0	4.1	0.4	0.8	-0.2	-2.0	0.1
Chest pain or discomfort	0.8	1.2	3.1	-1.8	-1.4	-0.7	-0.2	-0.5
Had major operations	0.8	0.9	2.6	-0.8	0.7	1.6	0.8	0.3
Osteoporosis (self-reported)	0.8	0.9	1.5	-1.2	1.0	0.6	0.6	1.2
Miserableness	0.8	1.4	5.9	-0.2	0.3	-0.6	0.7	2.4
Medication: Paracetamol	0.8	1.2	2.6	-1.6	0.5	1.0	1.3	0.8
Heart disease (siblings)	0.8	1.0	2.7	1.2	0.7	0.2	-0.6	1.6
Bipolar Disorder or Schizophrenia	0.7	1.7	7.5	2.7	0.4	-0.1	-0.7	0.7
HDL Cholesterol	0.7	1.1	4.4	0.9	0.6	0.3	0.1	2.1
Lupus	0.7	1.0	3.8	-0.7	-0.0	1.9	0.9	-0.4
Number of treatments/medications taken	0.7	1.2	3.5	-1.9	-0.1	-0.7	-1.3	-0.8
Relative age voice broke	0.7	1.1	3.9	2.0	0.5	0.3	-1.2	-0.0
Qualifications: CSEs or equivalent	0.7	0.9	2.2	0.7	1.5	-0.1	0.2	1.3
Stomach or abdominal pain in last month	0.7	0.9	2.9	-1.7	-0.7	0.5	0.8	0.4
Trunk fat mass	0.7	3.1	5.7	2.0	1.7	1.5	-2.4	-0.9
Pain all over the body in last month	0.7	0.7	2.0	-1.0	-0.2	0.7	1.4	-0.4
Exposure to tobacco smoke at home	0.7	0.8	1.9	0.2	-0.4	-1.4	-1.4	0.4
Medication: Amlodipine	0.7	1.0	2.9	-0.6	-1.3	-1.7	0.0	-0.1
Number of full brothers	0.7	0.8	2.0	-0.1	1.4	-0.1	-1.2	0.9
Comparative height size at age 10	0.7	3.9	11.0	-0.7	2.7	3.3	0.8	0.2
Back pain experienced in last month	0.7	1.0	1.6	-0.3	1.1	1.3	-1.1	-1.0
Breast cancer (self-reported)	0.7	0.8	3.0	0.7	0.4	1.7	0.5	-0.1
Guilty feelings	0.7	1.0	2.5	0.1	1.3	1.6	0.9	0.4
Mother’s age at death	0.7	0.9	2.9	0.5	-0.7	-0.7	-0.4	-1.7
Neuroticism (2016)	0.6	0.8	2.3	0.9	-0.1	-0.2	-1.5	-1.0
Hand grip strength (left)	0.6	1.6	3.2	1.4	1.1	0.7	-1.0	-1.8
Medication: Co-codamol	0.6	0.6	2.7	-1.6	0.5	-0.1	0.4	0.3
Medication: Metformin	0.6	0.9	2.9	1.0	0.3	-0.6	-1.7	0.1
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.6	-0.9	1.2	-0.2	0.1	1.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.8	0.2	0.2	1.2	0.7	1.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	-0.4	0.2	0.6	1.0	1.4
Number of full sisters	0.6	0.7	1.3	-1.0	-0.2	0.7	0.9	1.1
Average weekly red wine intake	0.6	0.9	1.6	0.5	1.3	1.0	1.0	-0.7
Commuting to job workplace: Walk	0.6	0.6	1.0	-0.9	-0.8	-1.0	-0.4	0.8
Osteoarthritis (self-reported)	0.6	0.7	2.3	0.5	1.0	-0.0	0.1	1.5
Medication: Aspirin	0.6	0.8	2.3	-1.5	-1.0	-0.7	-0.4	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	1.3	-0.0	-1.0	0.7	0.3
Medication: Bendroflumethiazide	0.6	0.8	1.4	0.4	-1.2	-0.6	-1.0	1.1
Leg fat mass (left)	0.6	2.3	8.3	1.2	-0.7	-1.0	-2.9	-0.3
Schizophrenia (2018)	0.5	1.1	4.0	2.0	0.5	0.5	1.0	-0.3
Mean Putamen Volume	0.5	0.6	1.6	0.3	0.3	1.1	-0.2	-1.3
Triglycerides	0.5	0.9	2.7	-1.6	-1.2	-0.1	0.2	-0.6
Average weekly fortified wine intake	0.5	0.5	1.4	-1.2	-0.9	0.0	0.2	0.7
Maternal smoking around birth	0.5	0.7	1.9	1.4	0.7	-0.2	-0.5	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.7	0.8	0.3	1.1	-0.4	-1.9
Had other major operations	0.5	0.6	0.9	-0.0	0.8	0.9	-0.7	0.9
Weight	0.5	2.2	9.2	1.3	0.4	0.3	-3.0	0.1
Falls in the last year	0.5	0.7	2.0	0.7	0.4	1.0	-0.2	1.4
Breastfed as a baby	0.5	0.6	1.0	1.0	-0.7	-0.5	0.8	-0.8
Medication: Paracetamol	0.5	0.9	2.2	-1.5	0.1	0.3	0.5	1.3
Eye problems/disorders: None of the above	0.5	0.5	0.9	0.2	-0.8	-0.9	0.5	0.9
Emphysema/chronic bronchitis	0.5	0.6	1.3	-0.6	-0.3	0.1	1.0	1.1
Migraine (self-reported)	0.5	0.6	1.4	1.2	0.4	-0.5	-1.1	-0.3
Whole body fat mass	0.5	2.1	6.4	1.6	0.8	0.6	-2.5	-0.8
Leg fat mass (right)	0.5	1.8	7.0	0.8	-0.8	-0.9	-2.6	-0.3
Pulse rate, automated reading	0.5	1.7	4.6	1.4	-0.1	-1.2	-2.1	0.5
Arm fat mass (left)	0.5	1.9	7.4	0.7	-0.5	-0.8	-2.7	-0.8
Alcohol drinker status: Never	0.5	0.6	1.7	1.3	0.6	0.7	-0.0	0.5
Leg fat percentage (left)	0.5	1.9	4.8	0.8	-1.0	-1.6	-2.2	-0.5
Pain experienced in last month	0.5	0.8	3.0	1.7	-0.4	0.1	0.8	0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.3	-1.0	-1.1	-0.6	-0.5	-0.3
Alcohol drinker status: Previous	0.5	0.6	1.3	0.1	1.1	0.5	-1.1	-0.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.0	-0.5	-0.1	1.0	1.0	-0.1
LDL Cholesterol	0.4	0.6	1.5	-0.6	-0.6	-0.6	0.6	1.2
Schizophrenia (2014)	0.4	0.9	3.0	1.7	0.8	0.6	0.7	0.3
Blood Eosinophil Count	0.4	3.1	7.8	-2.8	0.2	-0.4	1.7	2.2
Diabetes (mother)	0.4	0.5	1.0	-0.9	0.3	1.0	0.2	0.7
Supplements: Glucosamine	0.4	0.5	1.2	-1.1	0.5	1.1	-0.3	0.1
Alcohol usually taken with meals	0.4	0.6	1.4	0.9	0.8	0.5	0.2	-1.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.7	0.6	0.0	-0.5	0.2	1.3
Arm fat percentage (right)	0.4	1.5	5.4	0.6	-0.1	-0.8	-2.3	-1.1
Hip circumference	0.4	1.9	5.6	1.6	-0.1	-0.4	-2.4	-1.2
Time employed in main current job	0.4	0.5	1.1	-0.4	0.4	1.0	0.2	1.1
Number of live births	0.4	0.6	1.5	0.1	1.2	1.1	-0.0	0.2
Arm fat mass (right)	0.4	1.7	6.7	0.9	-0.1	-0.5	-2.6	-0.7
Hair/balding pattern: Pattern 4	0.4	1.0	2.9	-0.9	-0.2	0.9	-0.8	-1.7
Peak expiratory flow (PEF)	0.4	1.0	4.0	0.6	0.5	-0.4	-2.0	0.4
Body fat percentage	0.4	1.8	4.8	1.4	0.9	0.3	-2.2	-1.1
Leg fat percentage (right)	0.4	1.6	4.0	0.2	-1.1	-1.6	-2.0	-0.5
Arm fat-free mass (right)	0.4	2.3	9.4	0.7	-0.9	-0.6	-3.1	0.6
Mean time to correctly identify matches	0.4	0.7	3.0	0.1	-0.3	0.1	-0.6	1.7
Heart disease (mother)	0.4	0.5	1.0	-1.0	0.1	0.9	-0.9	0.0
Arm predicted mass (right)	0.4	2.0	8.5	0.7	-0.6	-0.5	-2.9	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.7	0.8	0.1	0.1	-1.3	-0.0
Leg fat-free mass (right)	0.4	2.0	7.2	1.2	0.1	0.3	-2.7	0.9
Arm fat percentage (left)	0.4	1.4	4.9	0.6	-0.2	-0.9	-2.2	-0.9
Ever had bowel cancer screening	0.4	0.5	1.2	-0.6	0.9	1.1	-0.1	-0.3
Leg predicted mass (right)	0.4	2.0	7.6	1.2	0.0	0.3	-2.7	1.0
Eye problems/disorders: Glaucoma	0.4	0.5	0.9	-0.1	0.9	0.9	0.7	-0.4
Basal metabolic rate	0.4	2.0	8.2	1.1	0.1	0.3	-2.9	0.6
Arm fat-free mass (left)	0.4	1.9	8.2	1.0	-0.3	-0.0	-2.9	0.4
Average weekly beer plus cider intake	0.4	0.6	1.9	-0.5	-0.3	-0.4	-1.4	-0.9
Supplements: Calcium	0.4	0.4	1.3	0.9	0.1	0.1	-1.1	0.2
Arm predicted mass (left)	0.4	2.3	9.9	1.0	-0.6	-0.3	-3.1	0.4
Depressed Affect (Nagel 2018)	0.3	0.7	2.6	-0.8	-0.4	0.5	1.6	0.0
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.4	0.4	0.9	0.6	0.8
Blood White Count	0.3	2.4	7.3	-2.7	-0.2	-0.0	1.9	-1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.3	1.0	1.1	0.0	-0.3	-0.6
Medication for hormone replacement therapy	0.3	0.4	0.7	-0.9	0.6	0.6	0.3	0.5
Leg fat-free mass (left)	0.3	1.7	6.6	0.8	0.1	0.5	-2.6	0.9
Townsend deprivation index at recruitment	0.3	0.5	2.1	-0.1	-0.1	-0.2	-0.5	1.5
Age when periods started (menarche)	0.3	0.7	1.5	1.2	1.1	0.5	-0.8	-0.2
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	0.1	0.3	0.5	0.7	0.8
Leg predicted mass (left)	0.3	1.6	6.7	0.6	-0.0	0.4	-2.6	0.8
Hair/balding pattern: Pattern 2	0.3	0.3	0.7	0.6	-0.7	-0.8	-0.5	-0.1
Diabetes (self-reported)	0.3	0.5	0.8	0.8	0.8	-0.1	-0.9	0.4
Trunk fat-free mass	0.3	1.5	6.3	0.8	-0.0	0.3	-2.5	0.5
Mouth/teeth dental problems: Dentures	0.3	0.4	0.9	-0.2	-0.9	-0.6	-0.9	-0.4
Blood clot in the leg (DVT)	0.3	0.4	0.9	-0.7	-0.9	-0.5	-0.5	-0.5
Worry too long after embarrassment	0.3	0.6	1.3	0.2	1.1	1.1	0.2	0.4
Number of children fathered	0.3	0.3	0.8	0.9	0.3	-0.7	0.2	-0.3
Health satisfaction	0.3	0.3	0.7	0.9	0.2	-0.2	-0.4	0.8
Alcohol intake frequency.	0.3	0.6	1.3	-1.1	-1.0	-0.7	-0.5	0.2
Supplements: Vitamin C	0.3	0.3	0.5	0.7	-0.3	0.7	-0.6	-0.2
Whole body fat-free mass	0.3	1.7	7.2	0.9	-0.1	0.3	-2.7	0.7
Mood swings	0.3	0.5	1.1	-0.5	-1.1	-0.5	0.2	0.7
Diabetes diagnosed by doctor	0.3	0.5	1.7	0.6	0.2	-0.5	-1.3	0.4
Whole body water mass	0.3	2.0	8.1	1.0	-0.2	0.2	-2.8	0.8
Diastolic blood pressure, automated reading	0.3	1.0	1.7	1.1	1.0	1.0	0.2	-1.3
Hair Pigment	0.2	5.9	12.6	2.7	3.5	2.7	0.3	1.6
Supplements: Zinc	0.2	0.2	0.4	0.6	-0.6	-0.0	0.2	0.3
Medication: Ramipril	0.2	0.3	1.1	0.0	-0.2	-0.4	-1.0	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.8	0.4	-0.6	0.2	-0.5
Illnesses of mother	0.2	0.3	0.5	0.6	0.5	-0.5	0.7	0.3
Trunk predicted mass	0.2	1.4	6.0	0.8	-0.1	0.3	-2.4	0.5
Birth weight of first child	0.2	0.4	0.9	0.6	1.0	0.3	-0.7	-0.3
Headache pain in last month	0.2	0.3	0.7	0.4	0.7	-0.1	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.1	-0.5	0.8	1.1	0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	-0.0	-0.0	-0.7	-0.1	0.9
Ever depressed for a whole week	0.2	0.2	0.7	-0.3	-0.1	-0.9	0.0	0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.3	0.8	0.1	0.1	0.7
Heel T-Score	0.1	0.9	2.7	-1.2	-0.7	0.3	0.2	-1.6
Tanning	0.1	1.6	3.2	1.3	-0.5	-0.9	-1.5	1.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.5	0.2	-0.3	-0.5	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	0.4	-0.4	0.3	-0.8	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	0.4	-0.1	0.1	0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.2	-0.3	0.4	0.1	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.3	-0.5	-0.3	-0.0	-0.1	0.5
Neck or shoulder pain in last month	0.1	0.1	0.4	0.0	-0.4	-0.1	-0.7	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	0.1	0.2	0.5	-0.6	0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

PIP4K2C

Models

Trait associations