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chr15:62,636,766-66,778,617

Best TWAS P=5.02e-50 · Best GWAS P=2e-45 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DENND4A	0.06	0.05	enet	18	0.05	7.1e-07	9.51	7.7	1.8e-14	0.79	0.72	0.28	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SLC24A1	0.05	0.03	lasso	7	0.03	3.0e-04	9.50	8.7	3.2e-18	0.80	0.53	0.35	FALSE
3	GTEx	Adipose Subcutaneous	VWA9	0.05	0.00	lasso	4	0.01	7.9e-02	10.02	-12.2	2.6e-34	-0.56	0.08	0.78	FALSE
4	GTEx	Adipose Subcutaneous	RP11-244F12.3	0.16	0.12	lasso	5	0.10	6.5e-09	5.71	5.7	1.2e-08	0.04	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	PTPLAD1	0.13	0.10	enet	20	0.08	5.6e-05	12.02	11.9	1.6e-32	0.67	0.20	0.70	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-244F12.3	0.15	0.00	lasso	5	0.00	2.2e-01	5.71	5.8	8.1e-09	0.02	0.01	0.96	TRUE
7	GTEx	Artery Tibial	DENND4A	0.05	0.01	enet	8	0.02	8.3e-03	14.15	12.5	1.4e-35	0.96	0.01	0.97	FALSE
8	GTEx	Brain Caudate basal ganglia	RP11-244F12.2	0.47	0.27	lasso	8	0.30	2.5e-09	5.59	5.2	1.8e-07	0.04	0.00	0.99	FALSE
9	GTEx	Brain Cerebellar Hemisphere	IGDCC4	0.19	0.12	lasso	7	0.10	1.2e-03	9.36	-8.5	2.5e-17	-0.81	0.28	0.41	FALSE
10	GTEx	Brain Cerebellar Hemisphere	DENND4A	0.29	-0.01	enet	28	0.04	4.0e-02	10.00	9.2	2.4e-20	0.42	0.07	0.23	FALSE
11	GTEx	Brain Cerebellum	IGDCC4	0.28	0.27	lasso	5	0.24	9.6e-08	8.91	-11.1	2.0e-28	-0.78	0.46	0.46	FALSE
12	GTEx	Brain Hippocampus	TPM1	0.34	0.10	lasso	5	0.17	1.0e-04	5.69	5.3	9.7e-08	0.03	0.02	0.90	FALSE
13	GTEx	Brain Hippocampus	RP11-244F12.2	0.36	0.39	lasso	6	0.36	2.4e-09	5.69	5.3	9.2e-08	0.03	0.01	0.99	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	DENND4A	0.16	0.09	lasso	4	0.06	8.8e-03	13.88	14.0	3.0e-44	0.98	0.01	0.92	FALSE
15	GTEx	Breast Mammary Tissue (Female)	SNX1	0.04	-0.01	lasso	3	0.04	3.0e-02	5.63	5.6	1.8e-08	0.04	0.03	0.23	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	PTPLAD1	0.18	0.18	enet	25	0.15	1.7e-05	12.60	-14.1	4.4e-45	-0.72	0.42	0.50	FALSE
17	GTEx	Cells Transformed fibroblasts	SLC24A1	0.11	0.10	enet	4	0.09	5.3e-07	9.93	-9.9	2.6e-23	-0.39	0.99	0.00	FALSE
18	GTEx	Cells Transformed fibroblasts	CSNK1G1	0.17	0.17	lasso	1	0.15	1.3e-11	5.57	5.6	2.5e-08	0.04	0.02	0.98	FALSE
19	GTEx	Cells Transformed fibroblasts	DENND4A	0.08	0.06	lasso	2	0.04	3.3e-04	9.36	-9.4	8.0e-21	-0.85	0.74	0.10	FALSE
20	GTEx	Colon Transverse	CSNK1G1	0.07	0.00	lasso	4	0.01	1.0e-01	3.07	5.8	6.7e-09	-0.01	0.05	0.44	TRUE
21	GTEx	Esophagus Muscularis	DPP8	0.11	0.03	enet	9	0.04	3.2e-03	11.37	-8.4	5.4e-17	-0.42	0.26	0.21	FALSE
22	GTEx	Heart Atrial Appendage	TRIP4	0.13	0.01	lasso	5	0.04	4.9e-03	3.20	5.8	5.9e-09	0.09	0.14	0.44	FALSE
23	GTEx	Lung	TPM1	0.09	0.03	lasso	5	0.03	1.6e-03	5.59	5.7	1.0e-08	0.03	0.01	0.98	FALSE
24	GTEx	Muscle Skeletal	IGDCC4	0.03	0.01	lasso	2	0.02	9.2e-03	8.60	-8.6	1.2e-17	-0.76	0.23	0.28	FALSE
25	GTEx	Nerve Tibial	PTPLAD1	0.09	0.02	lasso	7	0.03	4.4e-03	6.32	9.2	2.5e-20	0.27	0.26	0.03	FALSE
26	GTEx	Pancreas	ANKDD1A	0.19	0.05	enet	16	0.04	1.1e-02	1.77	-5.5	2.9e-08	-0.18	0.38	0.03	TRUE
27	GTEx	Pituitary	DENND4A	0.19	0.12	enet	9	0.10	1.5e-03	12.51	12.7	4.1e-37	0.73	0.10	0.53	FALSE
28	GTEx	Skin Sun Exposed Lower leg	IGDCC4	0.05	0.00	enet	9	0.00	6.1e-01	11.21	-5.2	1.9e-07	-0.38	0.04	0.05	FALSE
29	GTEx	Testis	DPP8	0.09	0.03	lasso	3	0.04	5.3e-03	9.97	-12.5	6.1e-36	-0.66	0.03	0.79	FALSE
30	METSIM	Adipose	PARP16	0.03	0.01	bslmm	327	0.01	2.8e-03	-2.30	-10.6	3.5e-26	-0.56	0.04	0.31	FALSE
31	METSIM	Adipose	PTPLAD1	0.06	0.02	bslmm	327	0.03	2.0e-05	10.00	9.9	4.6e-23	0.37	0.49	0.05	FALSE
32	YFS	Blood	SLC24A1	0.06	0.02	bslmm	339	0.03	5.8e-10	13.88	-11.8	5.6e-32	-0.70	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DPP8	0.07	0.00	enet	9	0.03	2.9e-03	0.34	-8.9	5.5e-19	-0.70	0.01	0.80	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SLC24A1	0.19	0.04	blup	40	0.04	1.5e-04	6.32	-8.8	8.5e-19	-0.40	0.04	0.05	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	DENND4A	0.01	0.01	blup	68	0.01	7.5e-03	9.27	-6.1	8.5e-10	-0.72	0.03	0.16	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	DPP8	0.08	0.02	lasso	4	0.05	6.1e-10	13.88	-9.1	6.9e-20	-0.81	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PTPLAD1	0.09	0.06	blup	46	0.06	5.2e-04	-9.91	-14.9	5.0e-50	-0.89	0.01	0.90	TRUE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIP4	0.08	0.03	blup	41	0.04	1.3e-03	4.48	5.1	3.1e-07	0.09	0.02	0.87	FALSE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	DPP8	0.25	0.14	enet	6	0.12	1.8e-04	0.34	-6.7	2.6e-11	-0.63	0.01	0.73	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPP8	0.03	0.01	blup	53	0.01	8.4e-03	8.91	-14.5	1.3e-47	-0.93	0.01	0.86	TRUE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC24A1	0.08	0.05	lasso	1	0.05	8.4e-04	9.97	-10.0	2.0e-23	-0.43	0.10	0.15	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	C15orf44	0.06	0.03	blup	34	0.03	9.1e-05	6.14	7.5	4.4e-14	0.13	0.10	0.81	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	SLC24A1	0.05	0.01	enet	8	0.02	6.1e-03	9.97	-7.5	5.1e-14	-0.37	0.02	0.18	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	DPP8	0.07	0.01	blup	53	0.03	1.7e-04	0.56	-9.9	4.5e-23	-0.75	0.02	0.92	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIP4	0.10	0.07	enet	7	0.10	2.1e-11	4.48	5.5	4.9e-08	0.10	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PPIB	0.06	0.04	lasso	5	0.03	9.8e-05	5.44	-5.6	2.4e-08	-0.06	0.00	0.98	FALSE
47	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SNX22	0.04	0.03	blup	26	0.03	2.0e-04	5.44	-6.2	4.5e-10	-0.07	0.00	0.95	TRUE
48	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	APH1B	0.06	0.02	blup	45	0.03	4.6e-03	4.04	-5.1	2.7e-07	0.03	0.00	0.11	TRUE
49	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C15orf44	0.07	0.02	blup	34	0.03	7.4e-03	0.95	6.1	1.3e-09	0.13	0.03	0.62	TRUE
50	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DENND4A	0.04	0.02	blup	67	0.02	1.3e-02	13.90	-9.7	4.6e-22	-0.89	0.02	0.69	FALSE
51	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DPP8	0.08	0.04	blup	53	0.06	2.2e-03	11.37	-12.6	1.9e-36	-0.75	0.06	0.42	TRUE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPP8	0.08	0.08	lasso	4	0.07	1.6e-07	13.85	-14.0	9.9e-45	-0.96	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Rectum Adenocarcinoma	DENND4A	0.17	0.08	blup	68	0.07	1.0e-02	13.90	-12.8	1.7e-37	-0.88	0.03	0.63	FALSE
54	The Cancer Genome Atlas	Soft Tissue Sarcoma	DENND4A	0.13	0.01	blup	69	0.03	9.5e-03	12.56	7.9	2.9e-15	0.29	0.02	0.04	FALSE
55	The Cancer Genome Atlas	Soft Tissue Sarcoma	DPP8	0.16	0.01	blup	53	0.03	9.7e-03	0.30	-8.5	2.6e-17	-0.74	0.01	0.29	FALSE
56	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DENND4A	0.09	0.05	lasso	4	0.03	3.3e-02	9.36	-9.5	2.0e-21	-0.83	0.04	0.32	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	DPP8	0.05	0.02	lasso	5	0.04	5.9e-05	13.85	-14.6	1.5e-48	-0.91	0.00	0.99	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	SLC24A1	0.04	0.03	lasso	1	0.03	4.7e-04	9.97	-10.0	2.0e-23	-0.43	0.09	0.10	FALSE