TWAS hub - TOX2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.440	0.0580	3.6e-11	0.309	NA	0.295	NA	0.309	9.6e-26	NA	2.1e-24	NA	1.1e-25
2	GTEx	Adipose Visceral Omentum	0.377	0.0700	1.6e-06	0.125	NA	0.378	NA	0.388	5.1e-07	NA	1.0e-20	NA	2.3e-21
3	GTEx	Breast Mammary Tissue	0.443	0.0750	8.7e-07	0.304	NA	0.279	NA	0.317	4.5e-16	NA	1.1e-14	NA	7.4e-17
4	GTEx	Breast Mammary Tissue (Female)	0.244	0.1025	2.1e-02	0.190	NA	0.106	NA	0.157	2.5e-06	NA	4.8e-04	NA	2.0e-05
5	GTEx	Heart Left Ventricle	0.285	0.0710	5.6e-05	0.104	NA	0.199	NA	0.156	3.4e-06	NA	7.8e-11	NA	1.1e-08
6	GTEx	Muscle Skeletal	0.180	0.0473	5.1e-05	0.087	NA	0.077	NA	0.077	7.2e-09	NA	5.2e-08	NA	4.7e-08
7	GTEx	Nerve Tibial	0.644	0.0422	0.0e+00	0.534	NA	0.604	NA	0.604	4.3e-44	NA	5.6e-53	NA	5.5e-53
8	GTEx	Skin Not Sun Exposed Suprapubic	0.348	0.0740	5.0e-06	0.255	NA	0.246	NA	0.262	3.3e-14	NA	9.6e-14	NA	1.3e-14
9	GTEx	Skin Sun Exposed Lower leg	0.157	0.0580	4.5e-03	0.080	NA	0.077	NA	0.070	3.5e-07	NA	6.2e-07	NA	2.0e-06
10	GTEx	Testis	0.199	0.0720	9.1e-03	0.091	NA	-0.006	NA	0.038	7.8e-05	NA	7.5e-01	NA	8.6e-03
11	METSIM	Adipose	0.182	0.0326	1.7e-16	0.071	0.127	0.163	0.161	0.162	8.5e-11	1.5e-18	1.2e-23	2.5e-23	1.7e-23

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Number of full sisters	6.6	8.0	11.4	-3.2	-2.9	-3.2	-3.3	-1.8	-3.2	-1.6	-3.4	-3.1	-1.3	-3.1
Hypothyroidism/myxoedema (self-reported)	4.3	8.3	15.0	-2.8	-2.9	-2.7	-2.8	-3.9	-2.9	-2.3	-3.0	-2.9	-0.9	-3.7
Pain all over the body in last month	3.9	4.2	7.4	-2.2	-2.0	-2.4	-2.2	-2.7	-2.1	-1.2	-2.1	-2.4	0.3	-1.7
Hearing difficulty/problems: Yes	3.8	5.9	11.6	-2.4	-2.5	-2.4	-2.3	-2.7	-2.7	-1.6	-2.5	-2.5	-0.7	-3.4
Neuroticism score	3.8	8.0	11.1	-3.1	-3.1	-3.1	-3.1	-2.7	-2.9	-2.3	-3.3	-3.0	0.0	-2.9
Loneliness, isolation	3.8	5.2	11.4	-2.0	-2.6	-2.1	-2.1	-2.1	-2.0	-2.1	-2.5	-2.2	-1.4	-3.4
Qualifications: nursing, teaching	3.8	5.8	8.3	2.8	2.8	2.8	2.9	0.7	2.7	1.6	2.9	2.8	0.1	2.5
Glaucoma (self-reported)	3.6	4.2	6.1	2.4	2.2	2.3	2.4	1.3	2.2	1.2	2.5	2.4	1.9	1.2
Eye problems/disorders: Diabetes related eye disease	3.5	3.9	8.0	-2.1	-2.3	-2.0	-2.1	-1.0	-1.9	-1.7	-2.1	-2.2	-0.5	-2.8
Medication: Levothyroxine sodium	3.5	6.0	11.8	-2.2	-2.5	-2.4	-2.2	-3.4	-2.4	-2.0	-2.6	-2.4	-1.4	-2.8
Mean Putamen Volume	3.3	3.8	7.8	-1.9	-2.4	-2.1	-1.9	-1.4	-1.7	-1.6	-2.1	-2.0	0.1	-2.8
Miserableness	3.3	5.6	8.3	-2.8	-2.1	-2.6	-2.7	-2.9	-2.6	-0.9	-2.8	-2.9	0.3	-1.8
Hypothyroidism (self reported)	3.2	7.4	12.5	-2.5	-3.0	-2.4	-2.5	-3.5	-2.4	-2.8	-2.8	-2.7	-0.7	-3.5
Ever had hysterectomy (womb removed)	2.9	3.3	5.5	-1.9	-2.3	-2.0	-1.8	-1.1	-1.6	-2.0	-1.9	-1.7	-1.2	-2.2
Major Depression (MDD)	2.6	3.1	7.5	-1.3	-2.2	-1.4	-1.3	-1.6	-1.4	-2.4	-1.4	-1.2	-1.7	-2.7
Birth weight	2.6	5.7	11.0	2.2	2.9	2.4	2.2	2.9	1.7	2.6	2.4	1.7	0.8	3.3
Worry too long after embarrassment	2.5	4.1	5.8	-2.4	-2.1	-2.3	-2.3	-2.1	-1.8	-1.1	-2.3	-2.3	0.9	-2.0
Number of incorrect matches in round	2.4	3.9	11.1	-1.4	-2.5	-1.4	-1.3	-1.6	-1.0	-2.6	-1.5	-1.2	-2.3	-3.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	10.1	-0.9	-2.5	-1.1	-0.9	-3.2	-0.7	-2.9	-1.3	-0.6	-2.5	-2.1
Neuroticism	2.3	5.7	8.3	-2.4	-2.7	-2.4	-2.4	-2.5	-2.3	-2.2	-2.7	-2.4	-0.2	-2.9
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	7.5	-2.4	-2.5	-2.5	-2.4	-2.3	-2.7	-1.5	-2.4	-2.3	0.1	-2.7
High blood pressure	2.3	6.5	14.7	-2.9	-2.3	-3.0	-2.9	-2.2	-3.8	-0.9	-2.9	-2.6	-0.8	-2.3
Breastfed as a baby	2.3	2.8	5.0	1.9	1.6	1.8	2.0	2.2	1.7	0.8	2.1	1.8	0.0	1.0
Medication for cholesterol, blood pressure or diabetes	2.3	3.8	8.1	2.3	1.6	2.3	2.2	1.7	2.8	0.3	2.1	2.4	0.2	1.7
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	7.9	-2.6	-2.4	-2.6	-2.6	-1.8	-2.8	-1.3	-2.5	-2.5	0.0	-2.3
Hypertension (Self-reported)	2.2	6.0	13.4	-2.7	-2.3	-2.8	-2.6	-2.3	-3.7	-1.1	-2.7	-2.4	-0.8	-2.3
Average weekly spirits intake	2.1	2.6	4.1	-1.9	-0.4	-1.8	-1.9	-1.6	-1.9	1.1	-1.8	-2.0	1.7	-0.1
Bilateral oophorectomy (both ovaries removed)	2.1	2.4	3.7	-1.8	-1.9	-1.9	-1.7	-0.1	-1.5	-1.2	-1.8	-1.8	-1.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.5	5.5	-1.7	-2.3	-2.0	-1.8	-1.5	-1.8	-1.9	-1.9	-2.1	-0.9	-2.1
Alcohol intake frequency.	2.1	4.9	10.8	-2.2	-2.5	-2.2	-2.1	-0.9	-2.0	-2.5	-2.2	-2.2	-1.5	-3.3
Vitamin and mineral supplements	2.0	2.7	6.6	1.1	2.3	1.2	1.1	1.6	1.1	2.3	1.3	1.0	2.6	1.5
Medication: Ramipril	2.0	2.5	4.3	-1.8	-1.4	-1.8	-1.8	-1.9	-2.1	-0.8	-1.8	-1.6	0.6	-1.4
Vascular/heart problems diagnosed by doctor	2.0	5.4	11.6	2.5	2.2	2.7	2.4	2.4	3.4	1.2	2.5	2.2	0.7	2.3
Pack years of smoking	2.0	2.9	5.0	-1.4	-2.2	-1.7	-1.4	-1.7	-1.4	-2.0	-1.6	-1.7	-1.0	-2.2
Depressed Affect (Nagel 2018)	1.9	4.0	5.6	-2.0	-2.2	-1.9	-2.0	-2.3	-1.9	-1.7	-2.3	-2.3	-0.1	-2.4
Mood swings	1.9	3.4	6.7	-1.9	-1.8	-1.7	-1.9	-2.6	-1.9	-1.5	-2.3	-1.8	0.5	-1.5
Guilty feelings	1.9	2.8	5.0	-1.8	-1.8	-1.6	-1.8	-1.4	-1.7	-1.5	-2.0	-1.7	-0.5	-2.2
Fed-up feelings	1.8	3.3	5.2	-1.7	-2.2	-1.7	-1.7	-2.3	-1.6	-2.2	-2.0	-1.8	-0.4	-1.6
Medication: Blood pressure	1.8	3.2	7.5	-2.1	-1.6	-2.1	-1.9	-1.5	-2.7	-0.5	-1.8	-1.9	-0.5	-1.7
Ever taken oral contraceptive pill	1.8	2.0	3.9	-1.9	-0.6	-1.5	-1.9	-1.3	-1.8	0.4	-1.8	-2.0	0.4	0.1
Chronic bronchitis/emphysema (father)	1.7	1.9	3.3	-1.5	-1.5	-1.6	-1.5	-1.3	-1.5	-0.9	-1.5	-1.3	-0.2	-1.8
Shortness of breath walking on level ground	1.7	2.0	8.1	-0.6	-1.5	-0.7	-0.6	-1.2	-0.3	-1.8	-0.8	-0.6	-2.9	-2.1
Overall health rating	1.7	3.7	7.6	-2.1	-1.4	-1.9	-2.2	-2.1	-2.8	-0.7	-2.2	-2.5	0.6	-1.1
Neuroticism (Nagel 2018)	1.6	3.7	7.5	-1.7	-2.4	-1.8	-1.8	-1.8	-1.7	-2.2	-2.0	-1.9	-0.3	-2.7
HDL Cholesterol	1.6	2.7	11.4	0.0	2.1	0.2	0.1	0.9	-0.4	3.2	0.4	-0.3	3.4	1.5
Current tobacco smoking	1.6	2.7	8.9	1.4	-1.2	1.0	1.3	-0.8	1.4	-2.8	0.8	1.3	-3.0	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	6.5	-1.0	-2.4	-1.3	-1.1	-1.0	-1.0	-2.6	-1.3	-1.2	-1.6	-1.9
Number of children fathered	1.6	1.8	3.6	1.0	1.9	1.1	1.1	1.4	1.0	1.7	1.1	0.6	1.7	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	4.9	1.4	-0.3	1.3	1.4	0.8	1.8	-1.6	1.3	1.4	-2.2	-0.3
Chest pain or discomfort	1.6	2.2	6.8	-1.5	-1.6	-1.4	-1.4	-1.1	-1.3	-1.3	-1.5	-1.4	-0.9	-2.6
Smoking status: Current	1.6	2.5	8.5	1.2	-1.3	0.9	1.2	-0.9	1.3	-2.8	0.7	1.1	-2.9	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	5.5	1.6	2.3	1.8	1.7	1.2	2.1	2.0	1.9	1.7	1.3	2.3
Blood Red Count	1.5	14.6	33.9	2.7	5.5	3.3	2.6	1.0	2.9	5.8	2.9	2.6	5.1	4.5
Cardiovascular Disease	1.5	4.8	12.7	-2.6	-1.8	-2.6	-2.6	-1.9	-3.6	-0.6	-2.6	-2.3	-0.5	-0.8
Sensitivity / hurt feelings	1.5	2.5	4.2	-1.9	-1.1	-1.9	-2.0	-1.7	-2.0	0.0	-1.9	-1.8	0.9	-0.3
Pack years adult smoking proportion	1.5	2.3	5.6	-0.9	-2.1	-1.2	-0.9	-1.5	-0.8	-2.4	-1.1	-1.2	-1.7	-2.0
Relative age voice broke	1.5	2.2	5.2	1.2	1.8	1.2	1.2	1.6	1.1	1.8	1.4	1.2	0.9	2.3
Worrier / anxious feelings	1.5	2.8	5.3	-1.5	-2.2	-1.6	-1.5	-2.3	-1.1	-2.1	-1.5	-1.2	-1.0	-2.0
Gout (self-reported)	1.5	2.0	4.6	-1.7	-0.4	-1.5	-1.8	0.6	-2.1	0.8	-1.8	-2.1	-0.2	0.1
Exposure to tobacco smoke outside home	1.5	2.0	2.9	1.7	1.4	1.5	1.6	1.7	1.7	0.8	1.6	1.5	-0.2	1.0
Heart disease (mother)	1.5	1.8	5.5	-1.0	-1.6	-0.9	-0.9	-0.9	-1.0	-1.7	-1.0	-0.7	-1.7	-2.4
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	9.2	0.0	2.1	0.4	0.1	0.1	-0.1	3.0	0.5	0.1	2.3	0.9
Reaction Time	1.4	2.7	4.3	1.9	1.6	2.0	1.9	2.1	2.0	0.9	1.8	1.8	-0.1	1.0
Frequency of depressed mood in last 2 weeks	1.4	1.9	5.4	-0.8	-2.1	-1.0	-0.8	-1.1	-0.5	-2.3	-1.1	-0.9	-0.2	-2.3
Nervous feelings	1.4	2.6	6.8	-1.0	-2.4	-1.3	-1.0	-1.5	-1.1	-2.6	-1.2	-0.9	-0.7	-2.4
Medication: Cholesterol lowering	1.4	2.2	4.1	-1.7	-1.2	-1.7	-1.6	-1.8	-2.0	-0.2	-1.4	-1.9	0.4	-1.4
Illnesses of mother	1.4	1.7	3.7	1.5	0.7	1.5	1.5	0.7	1.9	0.1	1.6	1.5	0.8	1.4
Medication: Gliclazide	1.4	1.6	2.3	-1.4	-1.2	-1.2	-1.4	-0.8	-1.5	-1.1	-1.4	-1.3	0.7	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	3.3	-1.1	-1.8	-1.1	-1.0	-1.8	-0.8	-1.7	-1.3	-1.2	-0.2	-1.7
Prospective memory result	1.3	1.5	7.1	-0.7	1.2	-0.5	-0.7	0.3	-1.1	2.7	-0.3	-0.9	2.2	0.4
Average weekly beer plus cider intake	1.3	1.8	5.2	-0.7	-2.1	-1.0	-0.8	-0.5	-0.8	-2.3	-1.1	-0.8	-2.1	-1.1
Worry (Nagel 2018)	1.2	2.4	8.6	-0.4	-2.2	-0.8	-0.4	-1.1	-0.3	-2.9	-0.6	-0.2	-1.6	-2.8
Breast Cancer	1.2	2.8	8.0	1.7	1.5	1.6	1.8	1.9	1.7	0.6	1.7	1.4	-0.4	2.8
Triglycerides	1.2	1.9	9.2	-0.3	-2.2	-0.4	-0.2	-1.7	-0.1	-3.0	-0.5	-0.3	-1.3	-1.3
Number of treatments/medications taken	1.2	2.1	5.9	-0.5	-1.8	-0.7	-0.5	-1.6	-1.1	-2.4	-0.9	-0.4	-2.0	-2.0
Supplements: Zinc	1.2	1.3	3.6	1.2	-0.3	1.0	1.3	0.5	1.4	-1.4	0.9	1.3	-1.9	-0.1
Medication: Metformin	1.2	1.7	3.8	-1.4	-1.6	-1.4	-1.3	-0.2	-1.2	-1.4	-1.4	-1.4	0.1	-1.9
Medication: Simvastatin	1.2	1.7	3.0	-1.4	-1.6	-1.7	-1.4	-1.1	-1.4	-0.8	-1.4	-1.3	0.5	-1.3
Time employed in main current job	1.2	1.4	2.0	1.3	1.3	1.2	1.3	1.2	0.9	1.2	1.4	1.2	-0.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	4.3	-1.2	-1.3	-1.1	-1.3	-0.5	-1.0	-1.2	-1.4	-1.2	-0.6	-2.1
Medication: Paracetamol	1.2	2.0	3.1	-1.4	-1.7	-1.4	-1.5	-0.8	-1.5	-1.8	-1.7	-1.4	-0.8	-1.1
Medication: Ventolin 100micrograms inhaler	1.2	1.6	2.9	-1.5	-1.0	-1.4	-1.5	-0.8	-1.3	-0.2	-1.3	-1.7	-0.5	-1.7
Suffer from ‘nerves’	1.2	1.9	2.8	-1.2	-1.7	-1.5	-1.3	-1.5	-1.3	-1.4	-1.4	-1.2	-0.7	-1.6
Alcohol drinker status: Previous	1.2	1.4	7.6	-0.4	-1.4	-0.4	-0.4	-0.4	-0.3	-2.0	-0.6	-0.6	-2.8	-0.8
Primary Biliary Cirrhosis	1.1	1.6	6.1	0.7	1.7	1.2	0.8	2.5	0.6	1.6	1.0	0.8	0.7	1.2
Ulcerative Colitis	1.1	1.6	4.7	0.9	1.5	1.1	0.9	1.4	0.9	1.6	1.2	1.0	0.3	2.2
Townsend deprivation index at recruitment	1.1	1.5	3.3	-1.2	-1.4	-1.1	-1.2	-0.6	-1.2	-1.2	-1.3	-1.4	-0.4	-1.8
Number of live births	1.1	1.6	2.9	-1.1	-1.5	-1.1	-1.1	0.3	-1.3	-1.5	-1.2	-1.2	-1.7	-1.3
Supplements: Vitamin C	1.1	1.3	6.1	-0.0	-1.7	-0.4	-0.1	-1.1	-0.2	-2.5	-0.4	-0.2	-1.9	-0.6
Medication: Paracetamol	1.1	1.6	3.6	-1.1	-1.7	-1.2	-1.2	-1.1	-1.1	-1.9	-1.4	-1.1	-0.8	-1.1
Alzheimer’s Disease (in father)	1.0	1.1	1.5	-1.2	-1.1	-1.2	-1.2	-1.2	-1.1	-0.3	-1.2	-0.7	-0.3	-1.2
Neuroticism (2016)	1.0	1.5	5.4	-0.3	-1.6	-0.5	-0.4	-0.6	-0.1	-2.3	-0.4	-0.4	-1.7	-2.1
Impedance of leg (right)	1.0	5.0	14.3	-1.1	-3.5	-1.6	-1.1	-1.8	-0.0	-3.8	-1.5	-1.3	-2.7	-3.0
Taking other prescription medications	1.0	1.6	3.0	-1.1	-1.5	-1.1	-1.1	-1.7	-1.4	-1.5	-1.3	-1.2	-1.0	-0.9
Qualifications: CSEs or equivalent	1.0	1.3	3.3	-1.5	-0.5	-1.2	-1.5	-0.8	-1.2	0.2	-1.4	-1.8	-0.5	-0.3
Fluid intelligence score	1.0	2.2	4.0	1.8	0.9	1.6	1.8	2.0	1.9	-0.1	1.8	1.6	0.2	0.6
Peak expiratory flow (PEF)	1.0	2.4	6.0	1.1	1.9	1.1	1.1	1.0	1.4	2.0	1.2	1.1	2.4	2.0
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.5	-1.3	-1.2	-1.2	-1.4	0.1	-1.2	-0.8	-1.6	-1.5	-0.7	-0.1
Arm fat percentage (left)	1.0	3.9	13.1	-1.1	2.0	-0.8	-1.2	1.3	-1.8	3.6	-0.9	-1.7	3.1	2.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.1	-1.1	-1.3	-1.2	-1.2	0.0	-1.1	-1.2	-1.2	-1.1	-0.8	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	5.2	-0.3	-1.2	-0.4	-0.4	-0.7	-0.4	-1.6	-0.4	-0.3	-2.3	-1.1
Back pain experienced in last month	1.0	1.5	3.4	1.3	0.2	1.2	1.3	1.8	1.5	-0.6	1.1	1.2	-1.7	0.4
Mineral and other dietary supplements	1.0	1.3	5.8	-0.2	1.7	0.2	-0.2	1.0	-0.3	2.4	0.1	-0.3	2.0	0.9
Eye problems/disorders: Glaucoma	1.0	1.2	2.7	1.5	0.8	1.3	1.5	0.3	1.4	0.1	1.4	1.6	0.2	0.3
Supplements: Calcium	1.0	1.1	1.6	1.0	1.3	1.1	1.0	1.2	0.9	1.0	1.1	1.1	0.8	1.2
HbA1C	0.9	1.0	3.3	-0.7	-1.5	-0.6	-0.6	-0.8	-0.6	-1.8	-0.6	-0.6	0.9	-1.0
Rheumatoid Arthritis	0.9	1.3	2.9	-1.3	-0.6	-1.1	-1.3	-0.9	-1.5	0.0	-1.2	-1.7	1.2	-0.6
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.7	-1.2	-1.3	-1.0	-1.1	-0.2	-0.9	-1.3	-1.1	-1.2	-0.6	-1.2
Hair/balding pattern: Pattern 2	0.9	1.2	5.1	0.1	-1.4	-0.1	0.2	0.1	0.6	-2.2	0.0	0.1	-2.1	-1.0
Tense / ‘highly strung’	0.9	1.5	3.5	-1.1	-1.5	-1.1	-1.1	-0.4	-1.0	-1.6	-1.2	-1.2	-0.8	-1.9
Qualifications: College or University degree	0.9	2.8	6.0	1.9	0.8	1.8	2.0	1.1	2.5	-0.3	1.7	2.1	-1.9	0.9
Medication for pain relief, constipation, heartburn	0.9	1.6	3.0	1.1	1.7	1.2	1.1	1.1	1.2	1.7	1.3	1.0	0.3	1.5
Medication: Ibuprofen	0.9	1.1	3.6	-0.5	-1.2	-0.6	-0.7	-0.6	-0.6	-1.5	-0.9	-0.5	-1.3	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.4	-1.0	-1.2	-1.0	-1.0	-1.1	-1.2	-1.1	-1.1	-0.9	0.3	-1.1
Depression (Nagel 2018)	0.8	1.2	3.7	-0.5	-1.6	-0.6	-0.5	-1.9	-0.3	-1.9	-0.8	-0.6	-0.1	-1.1
Coronary Artery Disease (CAD)	0.8	1.0	2.0	0.8	1.3	1.2	0.8	-0.1	1.0	1.0	1.0	1.4	0.6	1.2
Smoking Status	0.8	1.9	7.7	1.3	-0.6	1.0	1.3	0.7	1.2	-1.9	1.1	1.2	-2.8	0.4
Lung FEV1/FVC ratio	0.8	4.2	7.4	2.5	1.3	2.4	2.5	2.4	2.7	0.2	2.4	2.3	-0.9	0.8
Systolic blood pressure, automated reading	0.8	2.2	4.9	-1.7	-1.3	-1.8	-1.6	-2.0	-2.2	-0.3	-1.6	-1.3	0.3	-1.0
Heart attack	0.8	1.0	3.5	-0.9	-0.8	-0.9	-0.7	-1.9	-0.8	-0.8	-0.6	-0.8	0.9	-1.2
Pulse wave reflection index	0.8	1.0	1.9	-1.2	0.3	-0.8	-1.0	-0.3	-1.3	1.3	-1.1	-0.9	1.4	0.4
Medication: Amlodipine	0.8	1.1	2.4	-0.6	-1.3	-0.8	-0.7	-1.1	-1.3	-1.5	-0.8	-0.4	-1.5	-0.4
Family relationship satisfaction	0.8	1.0	5.3	-0.1	1.0	0.1	-0.1	2.3	-0.0	1.6	-0.1	-0.2	1.2	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.9	-0.9	-1.1	-1.0	-0.9	-1.4	-0.8	-1.2	-1.0	-1.0	-0.6	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	4.0	0.3	-1.0	0.3	0.3	-0.7	0.5	-2.0	-0.1	0.2	-2.0	-0.2
Illnesses of father: None of the above (group 1)	0.8	1.0	3.5	1.0	1.2	1.0	0.9	0.7	1.0	0.7	0.8	0.6	1.9	0.9
Ulcerative Colitis (UC)	0.7	1.3	3.3	0.6	1.5	0.8	0.7	1.4	0.6	1.5	1.0	0.8	0.8	1.8
Relative age of first facial hair	0.7	1.4	2.9	0.8	1.7	1.0	0.8	1.5	0.8	1.7	0.9	0.9	0.7	1.6
Serious illness, injury or assault to yourself	0.7	0.9	2.2	0.7	-0.4	0.5	0.8	1.1	1.0	-1.3	0.5	0.7	-1.5	-1.1
Medication: Atenolol	0.7	0.9	1.7	0.8	1.3	0.8	0.8	1.1	0.2	1.3	0.9	1.0	1.0	0.3
Arm fat percentage (right)	0.7	2.8	8.5	-1.1	1.4	-0.9	-1.2	1.2	-1.7	2.9	-1.0	-1.7	2.4	1.7
Mouth/teeth dental problems: Dentures	0.7	1.2	2.7	-1.3	-0.6	-1.1	-1.3	-0.4	-1.4	-0.1	-1.3	-1.4	0.0	-1.7
Exposure to tobacco smoke at home	0.7	0.8	2.9	-0.6	-1.3	-0.6	-0.5	-1.1	-0.3	-1.7	-0.5	-0.4	-0.8	-1.0
Hair/balding pattern: Pattern 4	0.7	1.6	6.9	-0.5	1.2	-0.3	-0.6	0.5	-0.9	2.3	-0.3	-0.5	2.6	1.4
Blood clot in the leg (DVT)	0.7	0.9	1.9	1.0	1.2	1.4	1.0	1.1	0.8	0.5	1.1	0.2	-0.3	1.0
Health satisfaction	0.7	1.0	1.9	-0.8	-1.0	-0.8	-0.8	1.0	-0.8	-1.2	-0.9	-1.1	-1.4	-0.8
Medication: Atorvastatin	0.7	0.9	1.5	1.1	1.0	1.2	1.1	-0.4	0.8	0.7	1.2	1.2	0.5	0.5
Age started oral contraceptive pill	0.7	0.9	2.9	0.8	1.2	0.9	0.8	0.6	0.7	1.1	0.9	0.8	1.7	0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	3.4	-0.8	-0.6	-0.8	-0.6	-1.8	-0.8	-0.6	-0.5	-0.8	1.2	-1.0
Intelligence (Savage-Jansen 2018)	0.6	1.9	6.6	1.6	0.9	1.3	1.4	2.6	1.6	0.3	1.3	1.4	0.2	0.5
Schizophrenia vs Biploar Disorder	0.6	0.7	4.2	0.2	-0.9	-0.0	0.2	-0.5	0.3	-1.6	-0.1	0.2	-2.0	0.1
Prostate Cancer	0.6	0.8	2.3	-0.3	-1.1	-0.5	-0.2	-1.2	-0.0	-1.4	-0.7	-0.5	-1.5	-0.9
Schizophrenia (2014)	0.6	1.4	7.0	0.7	-1.2	0.4	0.7	-0.6	0.7	-2.0	0.5	0.8	-2.6	0.3
Blood Platelet Count	0.6	6.5	12.8	-2.3	-3.6	-2.5	-2.3	-2.3	-1.3	-3.2	-2.6	-1.8	-1.9	-3.1
Respiratory disease	0.6	1.3	3.3	-1.4	-0.3	-0.9	-1.3	-1.8	-1.1	0.6	-1.2	-1.8	0.6	-0.0
Chronotype (morning person)	0.6	1.5	6.2	-1.0	1.1	-0.7	-1.0	0.1	-1.0	1.9	-0.6	-1.2	2.5	0.2
Trunk fat percentage	0.6	2.5	9.1	-0.8	1.6	-0.6	-1.0	1.4	-1.4	3.0	-0.6	-1.5	2.3	1.6
Maternal smoking around birth	0.6	0.9	3.9	0.1	-1.1	0.0	-0.1	-0.5	0.0	-2.0	-0.3	-0.3	-1.0	-1.6
Sitting height	0.6	4.4	7.3	2.2	2.4	2.4	2.2	2.7	2.2	1.7	2.2	1.9	0.3	1.9
Impedance of leg (left)	0.6	3.1	8.9	-0.8	-2.8	-1.2	-0.9	-1.8	0.2	-3.0	-1.1	-0.9	-1.8	-2.4
Qualifications: None of the above	0.6	1.2	2.5	-1.3	-0.8	-1.4	-1.3	0.0	-1.6	0.0	-1.2	-1.4	1.3	0.1
Trunk fat-free mass	0.6	3.2	6.8	2.0	1.3	2.1	2.0	2.6	1.6	0.1	2.0	1.8	-1.9	1.1
Alcohol intake versus 10 years previously	0.6	1.0	2.0	-1.1	-0.6	-0.9	-1.1	-1.4	-1.3	-0.5	-0.9	-1.1	0.8	-0.6
Medication: Lansoprazole	0.6	0.7	3.5	0.1	-0.9	-0.0	0.1	-0.1	0.3	-1.7	-0.1	0.1	-1.9	-0.6
Pulse wave Arterial Stiffness index	0.6	0.7	1.2	-1.1	-0.5	-1.0	-1.0	-0.4	-0.9	0.2	-1.0	-1.0	0.5	-0.7
Trunk predicted mass	0.6	3.5	7.8	2.1	1.5	2.2	2.1	2.8	1.6	0.3	2.0	1.9	-1.8	1.2
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.5	0.6	1.3	0.7	0.6	1.2	0.7	1.6	0.7	0.6	1.0	0.8
Body fat percentage	0.6	2.3	6.7	-1.1	1.2	-0.9	-1.2	1.1	-1.6	2.6	-0.9	-1.7	2.0	1.4
Leg fat percentage (right)	0.6	2.2	5.7	-1.7	-0.5	-1.8	-1.8	0.2	-2.1	0.8	-1.7	-2.4	0.4	-0.4
Age at first live birth	0.6	1.0	1.9	1.2	0.4	0.9	1.3	0.2	1.3	0.1	1.2	1.4	0.5	1.2
Medication: Seretide 50 evohaler	0.6	0.7	1.4	-1.1	0.0	-0.7	-1.1	-0.4	-1.0	0.8	-1.0	-1.2	0.0	-0.6
Comparative height size at age 10	0.6	3.0	12.0	1.6	-0.6	1.5	1.5	1.5	1.7	-2.3	1.3	1.1	-3.5	-1.0
Leg fat-free mass (right)	0.6	3.2	6.9	1.3	2.6	1.8	1.3	2.5	0.6	2.3	1.5	1.1	0.9	2.3
Long-standing illness, disability or infirmity	0.6	0.9	4.0	-0.1	-1.1	-0.0	-0.1	-0.8	-0.2	-2.0	-0.2	-0.2	-1.6	-1.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.0	-0.2	-1.1	-0.0	-0.1	1.4	-0.1	-1.7	-0.3	-0.4	-1.5	-1.4
Leg predicted mass (right)	0.6	3.0	6.6	1.3	2.6	1.7	1.3	2.4	0.6	2.3	1.5	1.0	0.9	2.3
Arm fat mass (left)	0.6	2.4	8.9	-0.2	2.1	0.1	-0.3	2.1	-0.9	3.0	-0.0	-0.7	1.8	2.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.7	-1.0	-0.7	-1.1	-0.9	-0.7	-1.3	0.1	-1.0	-1.3	0.4	-0.1
Medication: Bendroflumethiazide	0.6	1.0	3.8	-0.1	-1.1	-0.4	-0.0	-1.9	-0.8	-1.3	-0.1	0.6	-1.1	-1.3
Leg fat percentage (left)	0.6	2.0	4.9	-1.6	-0.1	-1.6	-1.7	0.1	-2.1	1.3	-1.5	-2.2	1.1	-0.0
Irritability	0.6	1.0	2.2	-1.1	-0.5	-0.9	-1.1	-0.5	-1.1	-0.0	-1.1	-1.5	1.3	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.5	0.8	1.1	1.2	0.8	1.0	0.6	0.6	0.9	0.2	-0.2	1.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.2	1.3	0.9	1.1	1.2	1.5	1.3	0.6	1.1	1.1	0.5	0.7
Angina	0.5	0.7	1.5	0.4	-0.6	0.2	0.6	-1.2	0.6	-1.2	0.6	0.7	-1.1	-1.0
Diabetes (father)	0.5	0.6	3.4	0.3	0.2	0.5	0.3	1.0	0.8	-0.3	0.3	-0.2	-1.8	0.7
Multivitamins +/- minerals	0.5	0.6	4.3	0.2	-0.8	0.1	0.3	-0.3	0.1	-1.2	0.1	0.2	-2.1	-0.4
Trunk fat mass	0.5	2.1	8.0	-0.2	1.9	0.0	-0.3	2.0	-0.8	2.8	-0.0	-1.0	1.7	1.8
Falls in the last year	0.5	0.7	2.0	1.1	0.5	0.9	1.0	1.4	0.8	0.1	0.7	0.6	-0.7	0.8
Depression (self-reported)	0.5	0.6	2.2	-0.7	-0.7	-0.8	-0.7	-1.5	-0.9	-0.5	-0.9	-0.6	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	3.7	1.3	0.7	1.4	1.3	1.5	1.9	-0.0	1.3	1.4	0.1	0.6
Arm fat mass (right)	0.5	1.9	6.4	-0.5	1.6	-0.2	-0.6	1.8	-1.2	2.5	-0.3	-0.9	1.6	1.8
Arm fat-free mass (right)	0.5	2.4	5.9	1.6	1.6	1.8	1.6	2.4	1.1	0.7	1.6	1.4	-1.1	1.4
Number of full brothers	0.5	0.6	1.1	1.0	0.1	0.8	1.0	-0.5	0.9	-0.6	0.8	1.1	-0.3	0.7
Wheeze or whistling in the chest in last year	0.5	0.9	1.8	-1.2	0.4	-0.8	-1.1	-0.4	-1.1	1.3	-1.1	-1.3	0.8	0.3
Pulse wave peak to peak time	0.5	0.6	1.0	1.0	0.5	1.0	0.9	0.6	0.8	-0.2	0.9	0.9	-0.5	0.7
Emphysema/chronic bronchitis	0.5	0.6	2.2	-0.4	-0.8	-0.5	-0.5	-0.1	-0.4	-1.0	-0.5	-0.8	-1.5	-0.9
Angina (self-reported)	0.5	0.7	1.7	0.3	-0.8	0.1	0.5	-1.3	0.4	-1.3	0.4	0.5	-0.9	-1.3
Migraine (self-reported)	0.5	0.7	3.3	0.1	1.2	0.4	0.1	0.7	0.0	1.1	0.5	0.6	0.6	1.8
Medication: Omeprazole	0.5	0.6	1.5	-0.5	-0.9	-0.5	-0.5	-1.1	-0.6	-1.2	-0.6	-0.4	-0.3	-1.0
Mean time to correctly identify matches	0.5	0.9	1.8	1.1	0.7	1.2	1.1	1.3	1.2	-0.0	1.1	0.9	-0.1	-0.4
Arm predicted mass (right)	0.5	2.5	5.7	1.6	1.7	1.8	1.6	2.4	1.1	1.0	1.7	1.4	-0.9	1.5
Leg pain on walking	0.5	0.6	4.1	-0.1	-0.8	-0.3	-0.2	0.4	-0.2	-1.2	-0.3	-0.3	-2.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	-0.8	-0.0	-0.7	-0.8	-0.6	-0.9	0.5	-0.7	-1.1	1.0	0.3
Illnesses of father: Heart disease	0.5	0.6	2.7	-0.6	0.8	-0.2	-0.6	-0.2	-1.0	1.6	-0.3	-0.8	0.8	0.5
Illnesses of siblings: Diabetes	0.5	0.7	1.3	0.9	0.9	0.8	0.9	1.1	0.9	0.4	0.9	0.8	-0.5	0.3
Whole body fat-free mass	0.5	2.6	6.9	1.6	1.8	1.9	1.6	2.6	1.1	1.0	1.7	1.4	-0.9	1.6
Ever had bowel cancer screening	0.5	0.6	2.1	-0.6	0.8	-0.3	-0.5	0.3	-0.9	1.4	-0.2	-0.5	1.3	0.4
Osteoarthritis (self-reported)	0.5	0.7	1.3	1.0	1.0	1.1	1.0	0.1	0.7	0.3	1.0	0.5	0.6	1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.8	-0.5	-1.1	-0.8	-0.5	-1.0	-0.5	-0.9	-0.6	-0.4	0.1	-1.4
Heart disease (siblings)	0.5	0.7	2.4	-0.8	0.4	-0.4	-0.7	0.3	-0.9	1.2	-0.7	-0.8	1.6	-0.1
Crohns Disease (2012)	0.4	0.7	3.0	0.5	1.4	0.7	0.4	-0.2	0.4	1.7	0.4	-0.1	1.1	0.5
Lupus	0.4	0.6	2.7	0.3	-0.6	0.3	0.3	0.2	0.5	-1.2	0.1	0.2	-1.6	-1.1
Blood White Count	0.4	3.1	10.3	-0.6	-2.5	-0.9	-0.6	-2.7	-0.1	-3.2	-0.9	-0.2	-2.1	-1.8
BMI	0.4	2.6	8.9	-0.8	1.8	-0.6	-1.0	1.8	-1.6	3.0	-0.6	-1.2	1.2	2.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	2.0	0.6	-0.4	0.6	0.6	-0.8	0.7	-1.4	0.5	1.0	-0.9	0.0
Leg fat-free mass (left)	0.4	2.0	5.6	0.9	2.1	1.3	0.9	2.4	0.2	2.0	1.0	0.5	0.5	1.9
Hand grip strength (right)	0.4	1.1	3.6	0.8	1.3	0.8	0.8	0.7	1.0	1.4	0.7	0.6	0.8	1.9
Average weekly fortified wine intake	0.4	0.5	1.0	-0.8	-0.5	-1.0	-0.7	-0.1	-1.0	0.2	-0.5	-1.0	1.0	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.6	-0.0	0.8	-0.0	-0.1	0.6	-0.4	1.0	-0.1	-0.2	1.3	1.1
Body mass index (BMI)	0.4	1.7	6.4	-0.5	1.5	-0.3	-0.6	1.3	-1.4	2.5	-0.4	-0.9	1.4	1.7
Leg predicted mass (left)	0.4	2.0	5.8	0.9	2.1	1.3	0.9	2.4	0.2	2.0	1.1	0.6	0.5	1.8
Alcohol usually taken with meals	0.4	0.6	2.0	0.5	1.3	0.6	0.5	0.5	0.3	1.4	0.5	0.9	0.7	0.8
Weight	0.4	1.7	5.2	0.6	1.9	0.8	0.5	2.3	-0.1	2.1	0.7	0.1	0.6	1.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-0.7	0.1	-0.7	-0.8	-0.7	-1.0	0.8	-0.8	-0.7	1.0	-0.6
Standing height	0.4	4.5	7.9	2.5	1.2	2.6	2.5	2.5	2.8	-0.5	2.5	2.1	-1.6	0.7
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.6	0.2	1.0	0.3	0.2	1.3	0.1	1.2	0.4	-0.3	0.9	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.8	-0.4	-1.0	-0.7	-0.4	-1.4	-0.7	-1.2	-0.6	-0.3	-0.1	-0.3
Whole body fat mass	0.4	1.7	6.1	-0.3	1.6	-0.1	-0.5	1.9	-1.0	2.5	-0.2	-1.0	1.5	1.6
Average weekly red wine intake	0.4	0.5	1.0	0.9	0.6	0.7	1.0	0.3	1.0	0.4	0.7	0.7	-0.8	0.6
Commuting to job workplace: Walk	0.4	0.4	1.0	0.8	-0.1	0.6	0.8	-1.0	0.7	-0.6	0.5	0.8	0.1	-0.6
Medication for cholesterol	0.4	0.7	1.2	0.7	1.1	0.9	0.7	0.8	0.9	0.9	0.7	0.4	0.8	0.8
Whole body water mass	0.4	2.4	6.5	1.6	1.7	1.8	1.5	2.5	1.0	1.0	1.6	1.3	-0.9	1.5
Number of self-reported non-cancer illnesses	0.4	0.6	1.5	-1.0	-0.3	-0.7	-0.9	-1.0	-1.2	-0.0	-0.9	-0.9	0.4	-0.3
Hearing aid user	0.4	0.5	1.4	-0.5	-0.7	-0.6	-0.5	-1.2	-0.8	-0.8	-0.7	-0.6	-0.8	-0.2
Commuting to job workplace: Public transport	0.4	0.5	1.6	0.2	-0.4	0.3	0.2	1.3	0.3	-0.9	0.2	0.4	-1.3	-0.8
High cholesterol (Self-reported)	0.4	0.7	1.2	-1.0	-0.4	-1.1	-0.9	-0.3	-1.1	0.7	-0.8	-0.9	1.1	-0.6
Alcohol drinker status: Never	0.4	0.4	1.4	0.5	-0.1	0.3	0.5	1.2	0.4	-0.4	0.4	0.7	-1.2	-0.6
Basal metabolic rate	0.4	2.2	6.8	1.4	1.8	1.6	1.4	2.6	0.8	1.2	1.4	1.1	-0.6	1.6
Arm fat-free mass (left)	0.4	2.0	6.2	1.4	1.2	1.5	1.4	2.5	1.0	0.4	1.4	1.2	-1.5	1.1
Diastolic blood pressure, automated reading	0.4	1.1	4.0	-0.7	0.9	-0.5	-0.6	-0.9	-1.1	2.0	-0.4	-0.3	1.5	1.3
Myopia	0.4	0.5	2.1	-0.2	-1.0	-0.3	-0.3	0.6	-0.3	-1.4	-0.4	-0.5	-1.1	-0.6
Pain experienced in last month	0.4	0.7	2.6	-0.4	0.4	-0.4	-0.3	-1.5	-0.6	1.4	-0.3	-0.2	1.6	-0.1
Arm predicted mass (left)	0.4	1.8	5.8	1.3	1.2	1.5	1.3	2.4	0.8	0.5	1.3	1.1	-1.5	0.9
Alzheimer’s Disease (in mother)	0.3	0.4	2.3	0.1	0.1	0.2	0.2	1.1	0.2	0.0	0.3	0.0	-1.5	-0.5
Age at First Birth	0.3	0.5	1.0	0.8	0.6	0.7	0.8	0.3	1.0	0.1	0.8	0.8	0.0	0.8
Bipolar Disorder (2011)	0.3	0.2	0.9	-0.3	-0.7	-0.3	-0.4	0.3	-0.1	-0.5	-0.5	-0.2	-0.9	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.7	0.0	0.6	0.2	0.1	0.1	0.2	0.7	0.1	0.1	1.3	0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	-1.1	-0.5	-0.9	-0.9	0.4	-0.9	-0.1	-0.8	-0.9	0.7	-1.0
Medication for hormone replacement therapy	0.3	0.4	1.0	-0.5	-0.8	-0.6	-0.5	-0.5	-0.0	-0.8	-0.5	-0.6	-1.0	-0.1
Medication: Co-codamol	0.3	0.4	0.7	-0.7	-0.6	-0.7	-0.7	-0.8	-0.9	-0.2	-0.5	-0.4	0.6	-0.1
Severe depression (siblings)	0.3	0.4	2.5	0.1	-0.6	-0.1	0.0	0.3	0.2	-0.9	-0.0	-0.2	-1.6	0.2
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.5	0.7	0.5	0.4	0.8	0.5	0.5	0.5	0.5	1.0	-0.3
Supplements: Glucosamine	0.3	0.4	0.7	0.7	-0.0	0.7	0.8	0.5	0.7	-0.7	0.8	0.7	-0.5	0.5
Waist circumference	0.3	1.1	3.6	0.0	1.3	0.2	-0.0	1.9	-0.6	1.6	0.1	-0.5	0.7	1.5
Had menopause	0.3	0.4	0.8	0.6	0.1	0.7	0.7	0.5	0.4	-0.6	0.6	0.9	-0.9	-0.2
Financial difficulties in last 2 years	0.3	0.3	2.0	0.0	-0.6	-0.2	-0.1	-1.4	-0.1	-1.0	-0.3	-0.3	-0.5	-0.1
Allergy	0.3	0.8	1.5	-0.8	-1.1	-1.2	-0.9	-0.8	-0.9	-0.7	-1.1	-0.2	0.8	-1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.4	-0.3	-0.7	-0.4	-0.3	-0.9	-0.3	-0.7	-0.4	-0.2	-0.4	-1.2
Hip circumference	0.3	1.3	4.1	0.4	1.7	0.6	0.4	2.0	-0.2	1.8	0.5	0.1	0.3	1.7
Father’s age at death	0.3	0.5	1.5	0.5	-0.1	0.4	0.5	-0.8	0.7	-0.5	0.6	1.1	-1.2	0.2
Happiness	0.3	0.4	1.0	-0.8	-0.4	-0.7	-0.8	0.8	-0.6	0.2	-0.7	-1.0	0.0	0.1
Asthma	0.3	0.6	1.4	0.5	1.2	0.9	0.6	0.3	0.8	1.2	0.7	-0.0	0.3	0.8
Length of working week for main job	0.3	0.3	1.8	0.2	0.6	0.4	0.3	-0.7	0.3	0.4	0.5	-0.1	1.4	0.0
Birth weight of first child	0.3	0.6	1.1	1.0	0.7	1.0	0.9	0.4	0.9	0.1	1.0	0.6	0.4	1.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.8	-0.9	0.1	-0.6	-0.8	0.3	-0.9	0.7	-0.8	-0.6	0.2	0.4
High blood pressure (siblings)	0.3	0.4	1.5	0.6	-0.3	0.2	0.5	-1.2	-0.0	-0.6	0.3	0.6	-1.1	0.2
Comparative body size at age 10	0.3	0.8	1.9	-0.9	-0.4	-1.0	-1.0	-0.5	-1.4	0.4	-1.0	-1.3	0.5	-0.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	-0.4	0.1	-0.6	-0.4	-0.3	-0.6	1.0	-0.4	-0.4	0.9	-0.3
Medication: Allopurinol	0.3	0.3	1.0	-0.6	-0.3	-0.5	-0.6	-0.0	-1.0	0.2	-0.8	-1.0	0.1	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	0.8	0.3	0.5	0.8	0.7	0.7	0.2	0.9	0.7	-0.6	0.2
Leg fat mass (right)	0.3	1.2	2.8	-1.0	0.3	-1.0	-1.2	0.9	-1.6	1.3	-1.0	-1.7	0.7	0.5
Pulse rate, automated reading	0.3	1.0	2.2	-1.2	-0.8	-1.3	-1.1	-0.8	-0.5	-0.3	-1.1	-1.5	0.5	-1.2
Smoking status: Previous	0.3	0.5	3.0	0.2	0.3	0.1	0.2	1.7	0.0	0.3	0.3	-0.0	-0.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	3.8	0.6	-0.2	0.7	0.6	0.7	0.9	-1.1	0.5	0.3	-1.9	-0.4
Diabetes diagnosed by doctor	0.3	0.5	1.8	-0.7	-0.7	-0.7	-0.6	0.4	-0.7	-0.4	-0.6	-0.7	0.3	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.7	-0.0	-0.5	-0.7	-0.1	-0.8	0.6	-0.6	-0.7	0.2	-0.6
Average weekly champagne plus white wine intake	0.3	0.4	1.0	-0.6	0.1	-0.6	-0.8	-0.8	-0.6	0.5	-0.7	-0.6	1.0	-0.3
Wears glasses or contact lenses	0.3	0.3	0.7	-0.5	0.1	-0.6	-0.5	-0.5	-0.6	0.8	-0.3	-0.6	0.9	0.4
Ever smoked	0.3	0.5	2.8	0.3	0.1	0.1	0.3	1.2	0.1	0.3	0.3	0.1	-1.1	1.7
Ever depressed for a whole week	0.3	0.4	1.7	0.5	0.2	0.6	0.5	0.9	0.5	-0.2	0.5	0.6	-1.3	0.1
Commuting to job workplace: Cycle	0.3	0.4	1.9	0.2	-0.5	0.3	0.3	0.1	0.6	-1.1	0.3	0.3	-0.1	-1.4
Leg fat mass (left)	0.3	1.2	2.4	-1.0	0.5	-0.9	-1.1	0.9	-1.5	1.5	-0.9	-1.5	1.0	0.7
Alzheimer’s Disease (including proxy)	0.2	0.2	1.3	-0.3	0.1	-0.0	-0.1	0.8	-0.3	0.3	0.0	-0.0	-1.2	-0.6
Crohns Disease (2017)	0.2	0.3	1.0	0.6	0.7	0.8	0.6	-1.0	0.6	0.5	0.4	-0.0	0.3	-0.3
Irritable Bowel Disease (IBD)	0.2	0.6	1.5	0.5	1.2	0.8	0.6	0.4	0.5	1.2	0.7	0.2	0.5	0.8
LDL Cholesterol	0.2	0.3	0.6	0.5	-0.1	0.4	0.6	-0.0	0.5	-0.5	0.6	0.7	-0.3	0.8
Heel T-Score	0.2	1.2	2.1	-1.2	-1.4	-1.2	-1.2	-0.9	-1.1	-1.1	-1.0	-1.2	-0.2	-1.1
Systolic Blood Pressure	0.2	1.2	4.1	-0.9	-0.7	-1.0	-0.9	-2.0	-2.0	-0.2	-1.1	-0.4	-0.1	0.4
Allergy or Eczema	0.2	0.6	1.4	-0.6	-0.7	-0.4	-0.5	-0.8	-0.7	-0.7	-0.4	-0.7	-1.1	-1.2
Hand grip strength (left)	0.2	0.4	2.4	0.3	0.7	0.3	0.2	-0.1	0.6	0.9	0.1	0.1	0.8	1.6
Diabetes (mother)	0.2	0.2	0.9	0.6	0.2	0.4	0.5	-0.2	0.5	-0.0	0.2	0.3	-1.0	0.2
Age when periods started (menarche)	0.2	0.4	4.0	-0.0	0.3	0.1	-0.1	-0.4	0.0	0.7	0.1	-0.1	2.0	0.4
Past tobacco smoking	0.2	0.5	2.3	-0.2	-0.0	-0.0	-0.1	-1.5	0.1	-0.2	-0.2	0.2	0.8	-1.4
Hearing difficulty/problems with background noise	0.2	0.3	1.4	-0.3	0.2	-0.2	-0.3	-0.1	-0.7	0.5	-0.4	-0.7	0.4	-1.2
Mouth/teeth dental problems	0.2	0.3	1.4	0.3	-0.4	-0.0	0.3	-1.2	0.5	-0.4	0.3	0.4	-0.2	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.0	0.6	0.8	0.7	0.6	1.4	1.2	0.7	0.6	0.7	0.6	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.6	0.7	0.5	0.7	0.6	0.8	0.8	0.2	0.5	0.7	-0.5	-0.1
Lung cancer (father)	0.2	0.2	1.0	-0.3	0.1	-0.4	-0.3	0.4	-0.4	0.3	-0.1	-0.5	1.0	-0.6
Loud music exposure frequency	0.2	0.2	1.3	0.1	0.2	0.1	0.1	0.2	0.0	0.2	0.0	0.1	0.7	1.1
Headache pain in last month	0.2	0.3	2.5	0.4	0.4	0.5	0.3	1.6	0.4	0.0	0.4	0.3	-0.3	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.8	2.1	0.8	0.6	1.0	0.8	1.2	1.4	0.2	0.9	0.8	0.4	0.7
Eye problems/disorders: None of the above	0.2	0.3	1.2	-0.4	0.3	-0.4	-0.4	-0.1	-0.4	0.6	-0.3	-0.5	0.7	1.1
Neck or shoulder pain in last month	0.2	0.3	1.3	0.2	-0.5	0.3	0.3	0.6	0.4	-1.1	0.1	0.1	-0.6	-0.9
Had major operations	0.2	0.3	0.6	-0.5	-0.4	-0.7	-0.6	-0.4	-0.6	-0.2	-0.7	-0.8	0.1	-0.2
Medication: Aspirin	0.2	0.2	1.4	-0.3	-0.3	-0.5	-0.2	-0.4	-0.7	-0.1	-0.2	-0.1	1.2	-0.3
Knee pain experienced in last month	0.2	0.4	0.7	-0.6	-0.6	-0.7	-0.6	0.5	-0.3	-0.7	-0.7	-0.9	-0.6	-0.6
Friendships satisfaction	0.2	0.2	0.3	0.4	0.5	0.6	0.4	0.6	0.5	0.3	0.4	0.5	0.3	-0.3
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.4	-0.1	0.5	0.5	-0.0	0.6	-0.5	0.4	0.6	-0.1	-0.7
Asthma (self-reported)	0.2	0.4	1.1	0.4	1.0	0.8	0.5	0.1	0.7	1.0	0.7	-0.0	0.2	0.9
Osteoporosis (self-reported)	0.2	0.2	0.5	0.4	-0.2	0.4	0.4	-0.6	0.3	-0.7	0.2	0.6	-0.0	0.1
Medication: Aspirin	0.2	0.2	0.9	-0.2	-0.5	-0.6	-0.2	-0.5	-0.5	-0.3	-0.1	-0.1	1.0	-0.6
Mother’s age at death	0.2	0.3	1.0	0.3	0.6	0.5	0.4	-0.4	0.5	0.6	0.6	0.5	1.0	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.8	0.2	-0.0	0.1	0.3	1.3	0.0	-0.4	0.4	0.1	-0.1	-0.1
Medication: Blood pressure	0.2	0.4	2.0	-0.6	-0.4	-0.6	-0.6	-0.4	-1.4	-0.1	-0.6	-0.2	-0.1	-0.5
Medication: Lisinopril	0.2	0.2	0.8	0.1	0.6	0.0	0.1	0.1	-0.6	0.9	0.4	0.3	0.6	0.7
Illnesses of father: High blood pressure	0.2	0.2	1.1	-0.1	-0.6	-0.2	-0.1	0.3	-0.2	-0.9	-0.1	0.2	-1.1	-0.3
Number of operations (self-reported)	0.2	0.3	0.7	-0.6	-0.1	-0.5	-0.6	0.2	-0.8	0.3	-0.7	-0.8	0.1	-0.6
Risk taking	0.2	0.3	1.6	0.3	0.5	0.4	0.3	1.2	0.3	0.3	0.1	-0.3	0.0	0.8
Basal cell carcinoma (self-reported)	0.2	0.2	1.3	0.4	-0.1	0.3	0.3	0.2	0.5	-0.4	0.2	0.5	-1.1	-0.4
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.3	-0.2	-0.2	-0.3	-0.6	-0.3	0.1	-0.3	-0.3	0.5	-0.2
Schizophrenia (2018)	0.1	0.3	1.6	0.2	-0.5	0.1	0.2	-0.6	0.1	-0.8	0.3	0.2	-1.2	0.4
Ovarian Cancer	0.1	0.2	1.0	-0.3	0.1	-0.2	-0.2	-0.5	-0.5	0.2	-0.2	-0.5	0.3	-1.0
Body Mass Index (BMI) (2010)	0.1	0.2	0.9	-0.1	-0.3	-0.5	-0.1	-0.6	0.1	-0.3	-0.0	0.3	-0.5	1.0
Fasting Glucose	0.1	0.1	0.8	-0.1	-0.1	-0.1	-0.1	-0.9	0.0	0.0	-0.0	0.2	-0.3	-0.0
Blood Eosinophil Count	0.1	0.8	5.7	0.3	-0.7	0.1	0.3	-2.4	0.3	-1.2	0.2	-0.1	-0.3	-1.0
Height	0.1	1.1	5.2	0.0	-0.8	0.0	-0.1	0.4	0.3	-1.0	-0.3	-0.8	-1.9	-2.3
Lung FVC	0.1	0.7	4.8	-0.7	0.1	-0.6	-0.7	0.3	-0.2	0.6	-0.5	-0.4	2.2	0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.4	-0.2	0.2	0.3	0.1	0.3	-0.7	0.1	0.4	-0.4	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	1.0	-0.2	-0.4	0.0	-0.1	-0.3	-0.2	-0.6	-0.1	-0.3	-1.0	-0.3
High blood pressure (mother)	0.1	0.1	0.6	-0.2	0.1	-0.1	-0.2	-0.3	-0.5	0.0	-0.2	0.2	-0.8	-0.1
Had other major operations	0.1	0.1	0.4	0.4	0.0	0.5	0.4	0.7	0.3	-0.4	0.2	0.2	-0.5	-0.1
Forced vital capacity (FVC)	0.1	0.4	1.3	0.4	0.6	0.5	0.4	1.1	1.0	0.5	0.4	0.5	0.4	1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.9	-0.2	-0.2	-0.1	-0.1	0.1	-0.2	0.0	-0.1	-0.1	-1.0	-0.3
Diabetes (self-reported)	0.1	0.2	1.0	0.1	-0.5	0.0	0.2	0.5	0.1	-0.7	0.1	0.0	-0.3	-1.0
Impedance of arm (right)	0.1	0.5	1.0	-0.7	-0.6	-0.8	-0.9	-0.4	-0.1	-0.2	-0.9	-1.0	0.8	-0.7
Pulse rate	0.1	0.1	0.5	-0.2	-0.2	-0.3	-0.2	0.7	0.2	0.1	-0.1	-0.4	-0.3	-0.1
Noisy workplace	0.1	0.1	1.2	-0.2	0.1	-0.1	-0.2	0.2	-0.2	0.3	-0.2	-0.2	-0.1	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.8	-0.1	-0.2	-0.2	-0.2	0.4	-0.1	-0.1	-0.3	-0.1	0.2	0.9
Impedance of arm (left)	0.1	0.4	2.9	-0.3	0.5	-0.2	-0.4	0.1	0.2	0.8	-0.3	-0.6	1.7	0.3
Age at last live birth	0.1	0.1	0.7	0.0	-0.8	-0.2	0.0	-0.3	0.1	-0.7	-0.0	0.1	-0.4	-0.2
Breast cancer (self-reported)	0.1	0.1	0.4	0.1	-0.4	0.0	0.1	-0.4	0.2	-0.7	0.1	0.3	0.0	-0.5
Financial situation satisfaction	0.1	0.2	0.4	-0.4	-0.1	-0.2	-0.5	0.6	-0.6	-0.2	-0.2	-0.7	0.6	-0.0
Fractured/broken bones in last 5 years	0.1	0.1	0.4	0.5	0.0	0.2	0.4	0.1	0.2	-0.2	0.5	0.7	0.1	-0.3
Unable to work because of sickness or disability	0.1	0.2	0.7	0.2	-0.2	0.2	0.1	-0.8	-0.0	-0.7	-0.0	0.1	-0.7	-0.5
Cholesterol lowering medication	0.1	0.1	0.5	-0.0	-0.6	-0.2	0.0	-0.3	0.1	-0.5	-0.2	0.3	-0.3	-0.7
Impedance of whole body	0.1	0.5	1.2	-0.3	-1.0	-0.5	-0.4	-0.6	0.6	-1.1	-0.5	-0.6	-0.2	-1.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.4	-0.1	-0.5	-0.1	-0.1	-0.5	-0.1	-0.5	-0.0	-0.1	-0.6	0.2
Waist Hip Ratio (WHR)	0.0	0.1	0.7	0.1	0.4	0.4	0.1	0.8	0.1	0.3	0.2	-0.1	-0.1	0.3
Hair Pigment	0.0	0.4	1.7	-0.1	0.8	0.2	-0.0	0.6	-0.1	1.1	0.0	0.1	1.3	0.9
Tanning	0.0	0.3	1.0	0.7	-0.1	0.5	0.7	-0.4	0.6	-0.6	0.7	1.0	-0.2	-0.0
Illnesses of siblings	0.0	0.1	0.4	-0.0	0.1	0.1	0.0	0.6	0.4	-0.1	0.0	-0.1	0.2	0.1
Ever had prostate specific antigen (PSA) test	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.1	0.3	0.1	-0.0	-0.2	-0.2	-0.3	-0.1

Hub : Genes

TOX2

Models

Trait associations