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chr2:217,967,913-220,744,561

Best TWAS P=2.8e-43 · Best GWAS P=1.16e-40 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CNPPD1	0.05	0.06	lasso	7	0.04	4.8e-06	-5.817	5.5	3.1e-08	-0.03	0.99	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PLCD4	0.06	0.09	blup	382	0.09	1.3e-10	-11.671	13.1	5.8e-39	-0.91	0.23	0.77	FALSE
3	GTEx	Adipose Subcutaneous	BCS1L	0.06	0.01	enet	9	0.04	2.3e-04	-3.758	11.3	1.5e-29	-0.68	0.07	0.27	FALSE
4	GTEx	Adipose Subcutaneous	USP37	0.05	0.03	lasso	6	0.03	2.0e-03	-11.256	-12.2	4.2e-34	0.91	0.42	0.55	FALSE
5	GTEx	Adipose Subcutaneous	SLC23A3	0.07	0.08	lasso	2	0.05	2.7e-05	-6.008	-5.8	5.0e-09	0.07	0.84	0.01	FALSE
6	GTEx	Artery Aorta	PLCD4	0.14	0.18	lasso	4	0.18	2.1e-10	-11.510	11.6	4.3e-31	-0.91	0.97	0.03	FALSE
7	GTEx	Artery Aorta	USP37	0.08	0.05	lasso	4	0.04	1.7e-03	-11.413	-10.7	1.5e-26	0.78	0.14	0.15	FALSE
8	GTEx	Artery Aorta	SLC23A3	0.18	0.18	lasso	7	0.17	1.1e-09	-6.008	-5.8	5.3e-09	0.08	1.00	0.00	FALSE
9	GTEx	Artery Coronary	PLCD4	0.13	0.02	lasso	5	0.02	8.5e-02	-11.618	6.8	8.7e-12	-0.57	0.16	0.15	FALSE
10	GTEx	Artery Tibial	PLCD4	0.07	0.02	lasso	2	0.03	9.9e-04	-11.580	12.1	1.0e-33	-0.88	0.65	0.16	FALSE
11	GTEx	Artery Tibial	SLC23A3	0.12	0.04	lasso	9	0.08	6.7e-07	-6.045	-6.1	9.2e-10	0.03	0.98	0.00	FALSE
12	GTEx	Brain Cerebellar Hemisphere	PLCD4	0.12	0.15	lasso	2	0.07	8.9e-03	-11.529	11.5	8.6e-31	-0.91	0.12	0.45	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RQCD1	0.13	0.04	lasso	11	0.01	2.1e-01	-11.642	-12.7	5.3e-37	0.85	0.10	0.35	FALSE
14	GTEx	Brain Cerebellar Hemisphere	RP11-548H3.1	0.18	0.07	enet	23	0.01	2.0e-01	-13.313	9.4	4.0e-21	-0.80	0.04	0.59	FALSE
15	GTEx	Brain Cerebellum	ZNF142	0.18	0.00	enet	35	-0.01	5.6e-01	-11.256	-7.9	2.4e-15	0.37	0.05	0.36	FALSE
16	GTEx	Brain Cerebellum	CNPPD1	0.13	0.18	lasso	4	0.15	3.6e-05	-6.010	6.3	3.1e-10	-0.01	0.51	0.08	TRUE
17	GTEx	Brain Cerebellum	USP37	0.13	0.16	lasso	1	0.15	4.2e-05	-11.671	11.7	1.8e-31	-0.90	0.20	0.58	FALSE
18	GTEx	Breast Mammary Tissue	BCS1L	0.05	0.03	enet	7	0.03	6.8e-03	12.457	12.3	1.1e-34	-0.85	0.07	0.81	FALSE
19	GTEx	Breast Mammary Tissue	USP37	0.20	0.02	lasso	5	0.01	1.1e-01	-11.529	-8.2	2.2e-16	0.73	0.06	0.14	FALSE
20	GTEx	Breast Mammary Tissue (Male)	BCS1L	0.10	-0.01	enet	7	0.00	3.1e-01	-12.863	13.3	1.4e-40	-0.97	0.07	0.33	FALSE
21	GTEx	Breast Mammary Tissue (Male)	USP37	0.08	-0.01	enet	5	0.00	4.3e-01	12.577	-10.3	5.5e-25	0.66	0.04	0.12	FALSE
22	GTEx	Breast Mammary Tissue (Male)	RQCD1	0.45	0.05	lasso	6	0.10	2.6e-03	-3.952	-5.3	1.4e-07	0.18	0.06	0.06	FALSE
23	GTEx	Breast Mammary Tissue (Female)	BCS1L	0.06	0.03	lasso	1	-0.01	7.1e-01	12.457	12.5	1.3e-35	-0.79	0.04	0.20	FALSE
24	GTEx	Cells EBV-transformed lymphocytes	CNPPD1	0.26	0.10	lasso	7	0.12	8.2e-05	-5.814	-6.0	1.5e-09	0.04	0.48	0.04	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	TTLL4	0.16	0.09	enet	13	0.08	1.6e-03	-12.996	-13.4	9.2e-41	0.93	0.18	0.67	FALSE
26	GTEx	Cells Transformed fibroblasts	USP37	0.11	0.06	enet	16	0.07	4.5e-06	-11.182	-11.2	6.1e-29	0.76	0.94	0.03	FALSE
27	GTEx	Cells Transformed fibroblasts	SLC23A3	0.07	0.10	lasso	2	0.08	1.1e-06	-6.008	-6.1	1.1e-09	0.07	0.97	0.00	FALSE
28	GTEx	Colon Transverse	CYP27A1	0.16	0.12	lasso	6	0.14	2.3e-07	-11.200	-12.0	2.3e-33	0.83	0.39	0.59	FALSE
29	GTEx	Esophagus Mucosa	TTLL4	0.08	0.08	enet	15	0.08	4.3e-06	12.457	-12.9	6.6e-38	0.86	0.41	0.59	FALSE
30	GTEx	Esophagus Mucosa	USP37	0.10	0.07	enet	42	0.06	5.6e-05	-11.529	-8.1	5.7e-16	0.65	0.23	0.73	FALSE
31	GTEx	Heart Atrial Appendage	SLC23A3	0.16	0.05	lasso	3	0.06	1.1e-03	-6.008	-5.1	2.9e-07	0.08	0.21	0.04	FALSE
32	GTEx	Heart Left Ventricle	RQCD1	0.06	0.05	lasso	3	0.03	9.0e-03	-11.527	-12.6	2.3e-36	0.96	0.09	0.83	FALSE
33	GTEx	Liver	PLCD4	0.24	0.15	lasso	2	0.15	4.5e-05	-12.880	-13.0	2.3e-38	0.96	0.22	0.65	FALSE
34	GTEx	Lung	BCS1L	0.06	0.00	enet	58	0.00	4.8e-01	-1.973	6.6	3.2e-11	-0.28	0.05	0.18	FALSE
35	GTEx	Nerve Tibial	PNKD	0.06	0.00	enet	22	0.02	2.6e-02	3.616	-6.1	1.1e-09	0.62	0.12	0.26	FALSE
36	GTEx	Nerve Tibial	TTLL4	0.15	0.13	enet	19	0.17	4.0e-12	12.569	12.1	6.2e-34	-0.89	0.18	0.82	FALSE
37	GTEx	Nerve Tibial	USP37	0.06	0.06	lasso	4	0.05	1.1e-04	-11.281	-11.6	3.5e-31	0.84	0.31	0.33	FALSE
38	GTEx	Nerve Tibial	SLC23A3	0.13	0.06	lasso	4	0.07	1.4e-05	-6.008	-6.8	9.4e-12	0.06	0.95	0.00	FALSE
39	GTEx	Pancreas	USP37	0.10	0.01	lasso	6	0.01	1.8e-01	-11.619	-6.6	3.4e-11	0.56	0.15	0.13	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	USP37	0.11	0.01	enet	13	0.07	1.9e-04	-2.236	-6.4	1.4e-10	0.63	0.19	0.50	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	SLC23A3	0.18	0.14	lasso	5	0.13	8.9e-08	-6.008	-6.6	3.1e-11	0.05	0.98	0.00	TRUE
42	GTEx	Skin Sun Exposed Lower leg	ZNF142	0.10	0.05	enet	26	0.07	1.5e-06	-3.779	-8.5	2.9e-17	0.46	0.47	0.38	FALSE
43	GTEx	Skin Sun Exposed Lower leg	SLC23A3	0.07	0.04	enet	10	0.05	3.0e-05	-6.486	-6.5	9.7e-11	0.06	0.88	0.00	FALSE
44	GTEx	Spleen	CYP27A1	0.21	-0.01	lasso	2	0.03	5.0e-02	-0.038	9.3	1.3e-20	-0.60	0.06	0.34	FALSE
45	GTEx	Testis	CYP27A1	0.20	0.18	lasso	4	0.26	4.0e-12	12.568	-13.5	2.7e-41	0.91	0.33	0.67	FALSE
46	GTEx	Thyroid	BCS1L	0.07	0.00	lasso	3	0.00	6.6e-01	-13.313	12.1	1.8e-33	-0.94	0.03	0.79	FALSE
47	GTEx	Thyroid	PLCD4	0.08	0.10	lasso	2	0.10	3.5e-08	-12.742	-12.1	1.2e-33	0.93	0.28	0.71	FALSE
48	GTEx	Thyroid	USP37	0.09	0.08	lasso	8	0.06	1.8e-05	-11.671	-11.5	8.0e-31	0.87	0.87	0.12	FALSE
49	GTEx	Thyroid	CYP27A1	0.07	0.05	enet	23	0.04	4.8e-04	-12.921	-13.8	2.8e-43	0.87	0.13	0.85	TRUE
50	GTEx	Whole Blood	CYP27A1	0.03	0.05	lasso	5	0.02	1.3e-02	-13.043	-13.2	5.3e-40	0.94	0.12	0.80	FALSE
51	GTEx	Whole Blood	RQCD1	0.04	0.02	lasso	2	0.00	2.4e-01	-11.671	12.8	8.7e-38	-0.93	0.19	0.28	FALSE
52	GTEx	Whole Blood	SLC23A3	0.10	0.09	lasso	5	0.09	2.0e-08	-5.817	-6.4	1.2e-10	0.03	1.00	0.00	TRUE
53	GTEx	Whole Blood	RP11-459I19.1	0.06	0.00	enet	36	0.02	1.3e-02	-13.043	-9.2	2.5e-20	0.68	0.09	0.82	FALSE
54	METSIM	Adipose	CTDSP1	0.07	0.05	lasso	5	0.06	9.9e-09	-11.203	9.7	2.9e-22	-0.74	0.58	0.42	TRUE
55	METSIM	Adipose	CXCR2	0.04	0.00	blup	436	0.02	1.1e-03	-4.082	7.8	6.7e-15	-0.41	0.25	0.12	FALSE
56	METSIM	Adipose	CYP27A1	0.06	0.04	lasso	7	0.04	1.1e-06	-12.996	-13.3	4.2e-40	0.91	0.20	0.80	FALSE
57	METSIM	Adipose	SLC23A3	0.06	0.06	lasso	6	0.05	1.3e-08	-6.008	-6.7	1.5e-11	0.08	1.00	0.00	FALSE
58	METSIM	Adipose	USP37	0.04	0.02	blup	405	0.02	1.5e-04	-11.609	-7.5	5.9e-14	0.57	0.91	0.07	TRUE
59	NTR	Blood	ARPC2	0.02	0.01	blup	462	0.01	4.8e-05	-1.651	5.4	5.7e-08	-0.27	0.92	0.00	FALSE
60	NTR	Blood	C2orf24	0.02	0.02	lasso	2	0.02	1.5e-07	-5.817	5.8	6.0e-09	-0.03	1.00	0.00	FALSE
61	NTR	Blood	CYP27A1	0.21	0.30	enet	44	0.31	3.8e-104	-12.996	-13.1	3.4e-39	0.90	0.14	0.86	FALSE
62	NTR	Blood	RQCD1	0.02	0.04	lasso	5	0.03	1.9e-11	-11.671	11.8	2.8e-32	-0.91	0.59	0.41	FALSE
63	NTR	Blood	TNS1	0.03	0.00	bslmm	540	0.01	5.4e-03	-1.649	-5.7	1.4e-08	0.13	0.21	0.02	TRUE
64	NTR	Blood	TTLL4	0.01	0.01	bslmm	385	0.01	7.0e-03	-12.921	-10.3	9.8e-25	0.77	0.11	0.63	FALSE
65	NTR	Blood	USP37	0.01	0.01	blup	407	0.01	1.7e-03	-12.969	-12.8	9.5e-38	0.89	0.08	0.73	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	PLCD4	0.05	0.04	blup	363	0.06	4.6e-08	-11.529	11.5	8.6e-31	-0.79	0.42	0.58	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	ZNF142	0.03	0.01	enet	8	0.01	7.3e-03	-13.055	-11.5	1.4e-30	0.80	0.16	0.69	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	FAM134A	0.15	0.10	enet	15	0.11	1.1e-13	-5.809	6.3	2.7e-10	-0.02	1.00	0.00	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	RQCD1	0.04	0.06	enet	31	0.07	3.1e-09	-12.866	-12.7	3.9e-37	0.95	0.19	0.81	FALSE
70	YFS	Blood	CYP27A1	0.32	0.52	lasso	16	0.53	2.9e-210	-13.086	-13.3	2.0e-40	0.92	0.16	0.84	FALSE
71	YFS	Blood	RQCD1	0.03	0.07	lasso	4	0.07	9.5e-21	-11.529	12.0	3.8e-33	-0.92	0.65	0.35	FALSE
72	YFS	Blood	SLC23A3	0.25	0.26	lasso	7	0.31	1.6e-105	-6.008	-6.9	4.8e-12	0.06	1.00	0.00	FALSE
73	YFS	Blood	TTLL4	0.02	0.02	lasso	10	0.01	6.9e-05	-13.158	-13.1	2.1e-39	0.93	0.12	0.88	FALSE
74	YFS	Blood	ZNF142	0.10	0.12	lasso	8	0.16	1.1e-51	-12.955	-12.0	2.1e-33	0.84	0.18	0.82	FALSE
75	The Cancer Genome Atlas	Colon Adenocarcinoma	VIL1	0.06	0.06	blup	50	0.05	6.3e-04	-11.091	10.2	3.0e-24	-0.82	0.04	0.45	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC23A3	0.04	0.02	blup	44	0.01	7.6e-03	-5.814	-6.8	1.1e-11	0.06	0.02	0.83	FALSE
77	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TTLL4	0.02	0.01	blup	57	0.01	1.4e-02	-12.794	-13.2	1.5e-39	0.97	0.02	0.80	FALSE
78	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC11A1	0.03	0.01	blup	51	0.02	1.1e-03	-4.300	-9.7	3.2e-22	0.62	0.06	0.18	TRUE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VIL1	0.02	0.01	blup	50	0.01	8.6e-03	-11.578	11.7	1.8e-31	-0.88	0.03	0.43	FALSE
80	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTLL4	0.03	0.04	enet	5	0.04	2.9e-03	-13.305	-13.3	3.7e-40	1.00	0.01	0.80	FALSE
81	The Cancer Genome Atlas	Brain Lower Grade Glioma	CYP27A1	0.04	0.04	enet	10	0.03	3.8e-04	-13.043	-11.5	9.4e-31	0.77	0.02	0.98	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	PLCD4	0.03	0.02	blup	61	0.02	2.1e-03	-12.742	12.6	1.8e-36	-0.94	0.12	0.56	FALSE
83	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF142	0.06	0.05	enet	11	0.05	3.1e-06	-3.696	-9.8	1.2e-22	0.65	0.42	0.44	FALSE
84	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CYP27A1	0.07	0.10	lasso	2	0.09	7.3e-05	-11.200	11.7	1.4e-31	-0.83	0.02	0.96	FALSE
85	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC11A1	0.03	0.03	blup	51	0.03	1.4e-04	-4.561	-8.9	3.9e-19	0.62	0.10	0.44	FALSE
86	The Cancer Genome Atlas	Lung Adenocarcinoma	TTLL4	0.04	0.01	blup	57	0.02	1.9e-03	-11.529	-6.8	1.2e-11	0.52	0.03	0.35	FALSE
87	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC11A1	0.06	0.01	blup	51	0.04	2.2e-05	-11.256	-10.2	1.3e-24	0.69	0.06	0.86	FALSE
88	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TTLL4	0.04	0.04	blup	58	0.03	1.3e-04	-13.307	-13.0	1.3e-38	0.93	0.01	0.99	FALSE
89	The Cancer Genome Atlas	Prostate Adenocarcinoma	USP37	0.02	0.02	enet	4	0.02	3.2e-03	-12.880	-12.8	2.6e-37	0.96	0.04	0.91	FALSE
90	The Cancer Genome Atlas	Stomach Adenocarcinoma	FAM134A	0.05	0.03	lasso	5	0.04	6.7e-04	-5.586	6.7	2.5e-11	-0.03	0.03	0.75	FALSE
91	The Cancer Genome Atlas	Stomach Adenocarcinoma	TTLL4	0.07	0.10	blup	57	0.09	4.9e-07	-11.527	-11.9	1.1e-32	0.88	0.05	0.95	FALSE
92	The Cancer Genome Atlas	Thyroid Carcinoma	USP37	0.05	0.03	blup	72	0.04	3.4e-05	-13.054	-12.1	8.4e-34	0.93	0.04	0.95	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF142	0.09	0.03	blup	46	0.03	7.6e-04	-12.742	-12.1	1.6e-33	0.88	0.07	0.71	FALSE
94	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RQCD1	0.16	0.06	enet	28	0.06	1.1e-02	-13.002	-8.7	4.8e-18	0.77	0.02	0.69	FALSE
95	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	USP37	0.08	0.02	blup	72	0.01	2.2e-01	-11.626	-12.2	4.2e-34	0.92	0.04	0.39	FALSE