Best TWAS P=2.82e-18 · Best GWAS P=9.88e-16 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LIME1 | 0.04 | 0.00 | bslmm | 439 | 0.01 | 3.3e-02 | -4.77 | 7.2 | 7.3e-13 | 0.00 | 0.28 | 0.02 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | TPD52L2 | 0.13 | 0.07 | bslmm | 418 | 0.08 | 4.5e-10 | -4.77 | 6.8 | 1.1e-11 | 0.27 | 0.96 | 0.03 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | ZBTB46 | 0.11 | 0.08 | lasso | 3 | 0.07 | 1.2e-08 | -7.72 | -7.7 | 1.3e-14 | -0.25 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | TCEA2 | 0.11 | 0.06 | lasso | 2 | 0.03 | 9.4e-04 | 7.21 | 7.2 | 5.2e-13 | 0.61 | 0.21 | 0.44 | FALSE |
| 5 | GTEx | Adrenal Gland | OPRL1 | 0.48 | 0.29 | enet | 21 | 0.22 | 1.5e-08 | -7.73 | -6.8 | 1.1e-11 | -0.79 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Adrenal Gland | RGS19 | 0.32 | 0.20 | lasso | 8 | 0.21 | 5.8e-08 | -7.73 | -8.0 | 1.6e-15 | -0.78 | 0.01 | 0.98 | TRUE |
| 7 | GTEx | Artery Aorta | TPD52L2 | 0.16 | 0.07 | enet | 15 | 0.16 | 4.4e-09 | 0.56 | -6.1 | 7.9e-10 | -0.20 | 0.71 | 0.03 | FALSE |
| 8 | GTEx | Artery Aorta | OPRL1 | 0.27 | 0.19 | lasso | 4 | 0.17 | 1.4e-09 | -7.73 | -8.7 | 2.8e-18 | -0.80 | 0.01 | 0.99 | TRUE |
| 9 | GTEx | Artery Aorta | TCEA2 | 0.09 | 0.04 | lasso | 3 | 0.03 | 1.3e-02 | -7.73 | 8.3 | 7.3e-17 | 0.77 | 0.01 | 0.98 | FALSE |
| 10 | GTEx | Artery Tibial | OPRL1 | 0.10 | 0.10 | lasso | 2 | 0.06 | 1.1e-05 | -7.73 | -8.0 | 1.4e-15 | -0.88 | 0.00 | 0.99 | FALSE |
| 11 | GTEx | Artery Tibial | RGS19 | 0.12 | 0.07 | lasso | 2 | 0.07 | 2.8e-06 | 8.03 | -7.9 | 2.3e-15 | -1.00 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Brain Cerebellar Hemisphere | OPRL1 | 0.27 | 0.14 | lasso | 7 | 0.17 | 4.4e-05 | -7.73 | -6.8 | 1.5e-11 | -0.75 | 0.02 | 0.81 | TRUE |
| 13 | GTEx | Brain Cerebellar Hemisphere | RGS19 | 0.36 | 0.10 | lasso | 5 | 0.07 | 8.2e-03 | -5.63 | -6.0 | 2.6e-09 | -0.57 | 0.02 | 0.64 | FALSE |
| 14 | GTEx | Brain Cerebellum | RGS19 | 0.28 | 0.22 | lasso | 4 | 0.18 | 7.2e-06 | -7.73 | -7.0 | 2.6e-12 | -0.79 | 0.01 | 0.96 | FALSE |
| 15 | GTEx | Breast Mammary Tissue | GMEB2 | 0.18 | 0.02 | lasso | 5 | 0.06 | 3.0e-04 | -4.67 | -6.4 | 1.2e-10 | -0.16 | 0.16 | 0.05 | FALSE |
| 16 | GTEx | Breast Mammary Tissue (Female) | GMEB2 | 0.36 | 0.06 | lasso | 4 | 0.05 | 1.2e-02 | -4.74 | -5.9 | 3.7e-09 | -0.03 | 0.16 | 0.06 | FALSE |
| 17 | GTEx | Cells Transformed fibroblasts | OPRL1 | 0.25 | 0.07 | enet | 13 | 0.12 | 5.5e-09 | 4.92 | -6.4 | 1.4e-10 | -0.73 | 0.03 | 0.97 | TRUE |
| 18 | GTEx | Cells Transformed fibroblasts | RGS19 | 0.37 | 0.28 | lasso | 8 | 0.29 | 3.2e-22 | 8.03 | -8.0 | 1.0e-15 | -0.96 | 0.00 | 1.00 | FALSE |
| 19 | GTEx | Colon Sigmoid | RGS19 | 0.27 | 0.07 | enet | 33 | 0.09 | 3.8e-04 | -5.94 | -7.2 | 7.3e-13 | -0.59 | 0.03 | 0.95 | FALSE |
| 20 | GTEx | Esophagus Gastroesophageal Junction | LINC00176 | 0.25 | 0.09 | lasso | 2 | 0.04 | 1.0e-02 | 5.96 | 6.0 | 2.2e-09 | 0.06 | 0.06 | 0.12 | FALSE |
| 21 | GTEx | Esophagus Mucosa | RGS19 | 0.43 | 0.28 | enet | 17 | 0.34 | 7.9e-24 | -7.73 | -7.8 | 5.3e-15 | -0.91 | 0.00 | 1.00 | FALSE |
| 22 | GTEx | Esophagus Muscularis | OPRL1 | 0.17 | 0.14 | lasso | 1 | 0.13 | 4.7e-08 | -7.73 | -7.7 | 1.0e-14 | -0.82 | 0.01 | 0.99 | FALSE |
| 23 | GTEx | Esophagus Muscularis | RGS19 | 0.22 | 0.10 | lasso | 4 | 0.10 | 1.6e-06 | -7.73 | -7.3 | 3.7e-13 | -0.78 | 0.01 | 0.99 | FALSE |
| 24 | GTEx | Muscle Skeletal | RGS19 | 0.26 | 0.16 | lasso | 4 | 0.16 | 5.1e-15 | 8.03 | -7.8 | 4.5e-15 | -0.98 | 0.00 | 1.00 | FALSE |
| 25 | GTEx | Nerve Tibial | OPRL1 | 0.20 | 0.15 | lasso | 3 | 0.14 | 3.3e-10 | -7.73 | -8.0 | 1.5e-15 | -0.81 | 0.01 | 0.99 | FALSE |
| 26 | GTEx | Pancreas | OPRL1 | 0.39 | 0.27 | lasso | 5 | 0.32 | 6.9e-14 | -7.73 | -8.1 | 6.5e-16 | -0.91 | 0.00 | 1.00 | FALSE |
| 27 | GTEx | Skin Not Sun Exposed Suprapubic | RGS19 | 0.51 | 0.28 | enet | 28 | 0.32 | 4.3e-18 | -7.73 | -7.0 | 3.5e-12 | -0.76 | 0.01 | 0.99 | TRUE |
| 28 | GTEx | Skin Sun Exposed Lower leg | OPRL1 | 0.14 | 0.10 | lasso | 6 | 0.11 | 4.4e-09 | 8.03 | -8.0 | 9.4e-16 | -0.95 | 0.00 | 1.00 | FALSE |
| 29 | GTEx | Skin Sun Exposed Lower leg | RGS19 | 0.42 | 0.26 | lasso | 6 | 0.33 | 4.6e-28 | -7.73 | -8.3 | 9.3e-17 | -0.94 | 0.00 | 1.00 | FALSE |
| 30 | GTEx | Stomach | OPRL1 | 0.36 | 0.23 | enet | 16 | 0.19 | 1.3e-09 | -7.73 | -7.8 | 6.5e-15 | -0.76 | 0.01 | 0.99 | FALSE |
| 31 | GTEx | Stomach | RGS19 | 0.18 | 0.25 | lasso | 2 | 0.25 | 2.2e-12 | -7.73 | -7.8 | 8.6e-15 | -0.82 | 0.01 | 0.99 | FALSE |
| 32 | GTEx | Thyroid | RGS19 | 0.23 | 0.14 | enet | 11 | 0.19 | 3.3e-14 | 8.03 | -8.1 | 7.9e-16 | -0.92 | 0.00 | 1.00 | TRUE |
| 33 | GTEx | Vagina | RGS19 | 0.39 | 0.08 | lasso | 8 | 0.03 | 7.5e-02 | 8.03 | -8.7 | 3.3e-18 | -0.94 | 0.00 | 0.92 | FALSE |
| 34 | GTEx | Whole Blood | OPRL1 | 0.09 | 0.06 | enet | 8 | 0.07 | 4.3e-07 | 7.66 | 7.7 | 1.5e-14 | 0.90 | 0.00 | 1.00 | FALSE |
| 35 | ROSMAP | Brain Pre-frontal Cortex | ZBTB46 | 0.11 | 0.07 | lasso | 1 | 0.06 | 5.2e-08 | -7.72 | -7.7 | 1.1e-14 | -0.24 | 0.02 | 0.98 | TRUE |
| 36 | ROSMAP | Brain Pre-frontal Cortex | C20orf201 | 0.10 | 0.09 | enet | 9 | 0.10 | 9.9e-13 | -5.63 | 6.5 | 7.8e-11 | 0.66 | 0.35 | 0.65 | FALSE |
| 37 | YFS | Blood | OPRL1 | 0.07 | 0.07 | lasso | 5 | 0.09 | 5.0e-27 | -7.73 | 7.4 | 1.6e-13 | 0.82 | 0.01 | 0.99 | FALSE |
| 38 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C20orf201 | 0.05 | 0.00 | enet | 12 | 0.01 | 6.8e-02 | 2.51 | 5.3 | 1.1e-07 | 0.55 | 0.01 | 0.10 | FALSE |
| 39 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RGS19 | 0.04 | 0.04 | blup | 48 | 0.03 | 1.1e-03 | -7.73 | -6.1 | 8.2e-10 | -0.71 | 0.01 | 0.86 | TRUE |
| 40 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RGS19 | 0.03 | 0.02 | blup | 48 | 0.02 | 6.9e-06 | 6.87 | -7.7 | 1.0e-14 | -0.69 | 0.01 | 0.98 | FALSE |
| 41 | The Cancer Genome Atlas | Colon Adenocarcinoma | RGS19 | 0.09 | 0.04 | enet | 4 | 0.04 | 2.8e-03 | -5.61 | -5.9 | 3.8e-09 | -0.57 | 0.07 | 0.70 | FALSE |
| 42 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RGS19 | 0.06 | 0.06 | blup | 47 | 0.05 | 1.4e-06 | -7.73 | -6.7 | 1.7e-11 | -0.80 | 0.01 | 0.99 | FALSE |
| 43 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC2A4RG | 0.03 | 0.01 | blup | 48 | 0.02 | 2.4e-03 | -4.80 | 5.3 | 9.2e-08 | 0.03 | 0.11 | 0.05 | TRUE |
| 44 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RGS19 | 0.12 | 0.05 | blup | 47 | 0.08 | 1.8e-05 | -5.63 | -5.9 | 3.8e-09 | -0.41 | 0.12 | 0.36 | FALSE |
| 45 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIME1 | 0.02 | 0.03 | blup | 47 | 0.02 | 6.2e-03 | -4.88 | -5.3 | 1.3e-07 | 0.01 | 0.07 | 0.11 | FALSE |
| 46 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OPRL1 | 0.03 | 0.02 | lasso | 1 | 0.01 | 3.5e-02 | -7.73 | -7.7 | 1.0e-14 | -0.82 | 0.00 | 0.94 | FALSE |
| 47 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RGS19 | 0.05 | 0.02 | blup | 48 | 0.02 | 1.1e-03 | 3.73 | -6.3 | 2.8e-10 | -0.75 | 0.03 | 0.90 | FALSE |
| 48 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RGS19 | 0.11 | 0.00 | blup | 48 | 0.03 | 1.7e-02 | 6.87 | -8.0 | 1.5e-15 | -0.64 | 0.04 | 0.35 | TRUE |
| 49 | The Cancer Genome Atlas | Prostate Adenocarcinoma | OPRL1 | 0.07 | 0.08 | lasso | 4 | 0.08 | 7.8e-09 | -5.63 | -6.4 | 1.6e-10 | -0.65 | 0.30 | 0.70 | FALSE |
| 50 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RGS19 | 0.07 | 0.05 | blup | 48 | 0.07 | 1.1e-07 | -5.63 | -8.2 | 3.3e-16 | -0.80 | 0.01 | 0.99 | FALSE |
| 51 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC2A4RG | 0.05 | 0.01 | blup | 48 | 0.02 | 2.0e-03 | -2.71 | 5.1 | 2.7e-07 | 0.06 | 0.19 | 0.05 | FALSE |
| 52 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RGS19 | 0.13 | 0.10 | enet | 5 | 0.11 | 1.8e-08 | 6.87 | -7.0 | 2.0e-12 | -0.70 | 0.03 | 0.97 | FALSE |
| 53 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RGS19 | 0.18 | 0.08 | enet | 10 | 0.07 | 2.2e-03 | 3.73 | -5.6 | 1.7e-08 | -0.60 | 0.12 | 0.30 | FALSE |
| 54 | The Cancer Genome Atlas | Thyroid Carcinoma | RGS19 | 0.07 | 0.04 | blup | 48 | 0.06 | 8.4e-07 | 4.95 | -6.3 | 2.3e-10 | -0.63 | 0.04 | 0.96 | FALSE |
| 55 | The Cancer Genome Atlas | Thyroid Carcinoma | UCKL1AS | 0.05 | 0.02 | blup | 41 | 0.03 | 4.6e-04 | 6.29 | -7.2 | 8.2e-13 | -0.16 | 0.00 | 0.96 | FALSE |
| 56 | The Cancer Genome Atlas | Thyroid Carcinoma | ZGPAT | 0.05 | 0.04 | blup | 60 | 0.03 | 2.3e-04 | -4.67 | 5.5 | 4.0e-08 | -0.04 | 0.81 | 0.05 | FALSE |