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chr3:51,616,334-53,778,875

Best TWAS P=4.12e-11 · Best GWAS P=6.31e-10 conditioned to 0.232

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Cells EBV-transformed lymphocytes	ITIH4-AS1	0.11	0.05	enet	10	0.02	5.1e-02	6.1	-6.6	4.1e-11	0.84	0.03	0.88	TRUE
11	GTEx	Breast Mammary Tissue	NT5DC2	0.13	0.12	enet	11	0.08	9.9e-05	6.1	6.4	2.0e-10	-0.92	0.01	0.98	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	RP5-966M1.6	0.16	0.07	enet	19	0.11	1.8e-04	-5.4	-6.3	3.0e-10	0.89	0.04	0.95	FALSE
24	GTEx	Lung	GLYCTK	0.12	0.09	lasso	6	0.08	1.5e-06	5.5	6.3	4.0e-10	-0.73	0.04	0.96	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	NEK4	0.04	0.05	blup	359	0.05	1.1e-06	5.6	6.2	4.5e-10	-0.88	0.07	0.93	FALSE
54	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ITIH4	0.23	0.01	enet	7	0.02	1.6e-02	-4.6	-6.2	4.5e-10	0.69	0.03	0.95	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ITIH4	0.04	0.03	blup	53	0.03	7.4e-04	-5.1	-6.1	8.3e-10	0.82	0.04	0.85	FALSE
13	GTEx	Breast Mammary Tissue (Female)	NT5DC2	0.09	0.08	lasso	1	0.06	5.9e-03	6.1	6.1	1.2e-09	-0.96	0.02	0.79	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ITIH4	0.05	0.02	blup	53	0.02	1.1e-02	-5.0	-6.1	1.3e-09	0.75	0.06	0.44	FALSE
27	GTEx	Lung	GLYCTK-AS1	0.11	0.09	lasso	5	0.09	3.0e-07	5.5	6.0	1.9e-09	-0.78	0.04	0.96	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	GNL3	0.15	0.23	enet	16	0.22	2.0e-28	5.6	6.0	2.5e-09	-0.90	0.09	0.91	FALSE
21	GTEx	Esophagus Muscularis	NEK4	0.06	0.00	lasso	3	0.02	2.8e-02	5.6	6.0	2.8e-09	-0.78	0.15	0.70	FALSE
4	GTEx	Artery Tibial	GNL3	0.08	0.06	lasso	3	0.06	3.0e-05	5.6	5.9	3.3e-09	-0.87	0.13	0.86	FALSE
46	YFS	Blood	GNL3	0.02	0.03	enet	11	0.03	2.9e-09	-4.8	5.9	3.7e-09	-0.85	0.40	0.60	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	PBRM1	0.15	0.14	enet	9	0.16	7.0e-15	6.0	-5.8	7.0e-09	0.85	0.00	1.00	FALSE
16	GTEx	Cells Transformed fibroblasts	NEK4	0.07	0.11	lasso	5	0.08	7.2e-07	4.8	5.7	1.0e-08	-0.88	0.12	0.88	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	GLT8D1	0.10	0.01	enet	7	0.03	4.4e-06	-2.2	-5.7	1.0e-08	0.68	0.00	0.84	FALSE
6	GTEx	Brain Cerebellum	GNL3	0.14	0.07	enet	43	0.09	1.3e-03	-4.5	5.7	1.4e-08	-0.81	0.24	0.63	FALSE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ITIH4	0.14	0.08	lasso	3	0.10	7.0e-12	-5.4	-5.7	1.5e-08	0.71	0.10	0.90	FALSE
60	The Cancer Genome Atlas	Rectum Adenocarcinoma	ITIH4	0.12	0.09	blup	53	0.06	1.4e-02	-4.7	-5.7	1.5e-08	0.85	0.03	0.54	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	ITIH4	0.20	0.12	enet	8	0.16	6.0e-15	-5.0	-5.7	1.5e-08	0.50	0.70	0.30	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPCS1	0.08	0.04	lasso	2	0.04	4.7e-08	5.6	-5.7	1.6e-08	0.90	0.00	1.00	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	TMEM110	0.02	0.01	blup	321	0.02	9.7e-04	-5.1	-5.6	1.7e-08	0.86	0.09	0.77	FALSE
22	GTEx	Esophagus Muscularis	GNL3	0.06	0.12	lasso	1	0.10	1.5e-06	5.6	5.6	2.1e-08	-0.90	0.08	0.92	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPCS1	0.04	0.03	enet	1	0.03	2.9e-04	5.6	-5.6	2.1e-08	0.90	0.00	0.91	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	ITIH4	0.08	0.09	blup	53	0.08	3.1e-05	-4.9	-5.6	2.3e-08	0.64	0.34	0.53	FALSE
7	GTEx	Brain Cerebellum	GLYCTK	0.15	0.10	lasso	12	0.11	3.2e-04	5.5	-5.6	2.4e-08	0.62	0.05	0.89	FALSE
39	NTR	Blood	TMEM110	0.02	0.01	blup	391	0.01	1.1e-04	-5.4	-5.6	2.6e-08	0.79	0.02	0.98	FALSE
12	GTEx	Breast Mammary Tissue (Female)	NEK4	0.02	-0.01	lasso	2	0.01	1.4e-01	5.6	5.5	2.8e-08	-0.63	0.04	0.19	FALSE
10	GTEx	Breast Mammary Tissue	NEK4	0.06	0.03	enet	7	0.06	7.8e-04	4.9	5.5	2.9e-08	-0.76	0.06	0.79	FALSE
31	GTEx	Spleen	GLYCTK	0.56	0.14	enet	10	0.13	4.1e-04	5.6	5.5	3.0e-08	-0.64	0.05	0.90	FALSE
35	GTEx	Thyroid	GLYCTK	0.13	0.19	lasso	3	0.17	7.1e-13	5.5	5.5	3.1e-08	-0.64	0.04	0.96	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM110	0.13	0.06	blup	59	0.08	3.3e-09	-5.4	-5.5	3.3e-08	0.80	0.08	0.92	FALSE
26	GTEx	Lung	ITIH4-AS1	0.32	0.26	lasso	6	0.26	8.0e-20	-5.0	-5.5	3.4e-08	0.56	0.73	0.27	FALSE
5	GTEx	Artery Tibial	GLYCTK	0.04	0.02	enet	4	0.01	4.9e-02	5.4	5.5	3.5e-08	-0.68	0.07	0.79	FALSE
19	GTEx	Esophagus Mucosa	NEK4	0.05	0.03	lasso	8	0.02	2.4e-02	5.4	5.5	3.7e-08	-0.80	0.14	0.80	FALSE
8	GTEx	Brain Cerebellum	GLYCTK-AS1	0.09	0.14	lasso	8	0.12	1.6e-04	5.5	-5.5	3.9e-08	0.63	0.06	0.64	FALSE
61	The Cancer Genome Atlas	Soft Tissue Sarcoma	ITIH4	0.03	0.03	lasso	4	0.03	5.1e-03	-5.4	-5.5	4.1e-08	0.75	0.03	0.57	FALSE
20	GTEx	Esophagus Mucosa	GLYCTK	0.11	0.11	lasso	3	0.10	3.8e-07	5.4	5.5	4.2e-08	-0.63	0.05	0.95	FALSE
28	GTEx	Muscle Skeletal	ITIH4-AS1	0.06	0.03	lasso	4	0.06	2.3e-06	-4.3	-5.5	4.5e-08	0.78	0.28	0.72	FALSE
45	YFS	Blood	GLYCTK	0.15	0.14	enet	17	0.13	1.1e-41	5.5	5.5	4.8e-08	-0.62	0.05	0.95	FALSE
37	GTEx	Whole Blood	ITIH4-AS1	0.33	0.24	lasso	7	0.25	9.7e-23	-5.0	-5.5	4.9e-08	0.57	0.72	0.28	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	RP5-966M1.6	0.17	0.06	lasso	5	0.04	4.2e-03	-5.0	-5.4	5.6e-08	0.49	0.46	0.17	FALSE
18	GTEx	Colon Transverse	ITIH4-AS1	0.20	0.03	lasso	4	0.05	2.4e-03	-5.0	-5.4	5.8e-08	0.52	0.30	0.15	FALSE
29	GTEx	Pituitary	SFMBT1	0.16	0.01	enet	9	0.02	1.2e-01	-4.5	-5.4	5.8e-08	0.73	0.12	0.49	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	GLYCTK	0.05	0.08	lasso	5	0.08	2.5e-10	5.4	5.4	6.5e-08	-0.63	0.05	0.95	FALSE
40	NTR	Blood	WDR82	0.02	0.03	blup	325	0.03	4.9e-09	5.4	-5.4	7.3e-08	0.73	0.03	0.97	FALSE
33	GTEx	Testis	NT5DC2	0.11	0.16	enet	8	0.11	1.0e-05	4.9	5.4	8.5e-08	-0.88	0.07	0.92	FALSE
9	GTEx	Brain Nucleus accumbens basal ganglia	TMEM110	0.13	0.07	lasso	3	0.05	1.5e-02	-4.8	-5.3	8.6e-08	0.64	0.14	0.10	FALSE
47	YFS	Blood	PPM1M	0.07	0.06	lasso	4	0.07	3.8e-22	5.5	5.3	8.6e-08	-0.60	0.03	0.97	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	ITIH4	0.17	0.16	lasso	5	0.14	3.1e-15	-5.1	-5.3	9.0e-08	0.59	0.64	0.36	FALSE
23	GTEx	Esophagus Muscularis	GLYCTK	0.09	0.10	lasso	4	0.08	9.7e-06	5.5	5.3	9.7e-08	-0.70	0.09	0.91	FALSE
17	GTEx	Colon Sigmoid	NT5DC2	0.08	0.07	enet	8	0.06	4.5e-03	4.4	5.3	1.2e-07	-0.90	0.04	0.84	FALSE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	ITIH4	0.10	0.02	blup	53	0.05	1.2e-02	-5.1	-5.3	1.2e-07	0.68	0.04	0.22	FALSE
32	GTEx	Spleen	GLYCTK-AS1	0.32	0.08	enet	18	0.09	2.2e-03	5.6	5.3	1.4e-07	-0.61	0.06	0.79	FALSE
36	GTEx	Thyroid	GLYCTK-AS1	0.08	0.07	enet	10	0.08	9.7e-07	5.5	5.2	1.5e-07	-0.64	0.06	0.94	FALSE
1	GTEx	Adrenal Gland	RP5-966M1.6	0.11	0.07	lasso	5	0.05	6.6e-03	-5.0	-5.2	1.7e-07	0.56	0.24	0.19	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ITIH4	0.04	0.02	blup	53	0.03	3.0e-04	-4.7	-5.2	1.7e-07	0.79	0.20	0.43	FALSE
25	GTEx	Lung	TMEM110	0.13	0.10	lasso	7	0.07	8.4e-06	-4.9	-5.2	1.8e-07	0.58	0.81	0.19	FALSE
34	GTEx	Thyroid	NEK4	0.09	0.09	lasso	4	0.10	4.1e-08	-4.5	5.2	2.2e-07	-0.81	0.44	0.56	FALSE
38	METSIM	Adipose	GNL3	0.04	0.06	enet	25	0.05	4.5e-08	-4.4	5.2	2.3e-07	-0.80	0.50	0.50	FALSE
2	GTEx	Artery Aorta	TMEM110	0.19	0.08	enet	16	0.10	6.0e-06	-5.1	-5.2	2.4e-07	0.63	0.69	0.28	FALSE
3	GTEx	Artery Aorta	ITIH4-AS1	0.38	0.45	lasso	10	0.42	1.4e-24	-5.1	-5.1	3.0e-07	0.56	0.73	0.27	FALSE