[Hub]/) : Traits : Pulse rate, automated reading :

chr3:51,306,844-54,077,726

Best TWAS P=1.14e-15 · Best GWAS P=4.86e-17 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GNL3 0.15 0.07 bslmm 390 0.08 1.3e-09 -4.24 5.1 3.1e-07 0.02 0.97 0.02 TRUE
2 CommonMind Brain Pre-frontal Cortex TKT 0.06 0.05 enet 12 0.03 2.7e-04 4.16 5.2 1.8e-07 -0.32 0.98 0.01 FALSE
3 GTEx Adipose Subcutaneous TMEM110 0.12 0.05 lasso 6 0.03 7.3e-04 -6.42 5.5 3.6e-08 0.06 0.27 0.06 FALSE
4 GTEx Brain Frontal Cortex BA9 GNL3 0.14 0.15 enet 10 0.13 2.3e-04 4.13 5.1 2.8e-07 -0.16 0.20 0.06 FALSE
5 GTEx Breast Mammary Tissue NT5DC2 0.13 0.12 enet 11 0.08 9.9e-05 5.23 5.3 1.4e-07 -0.19 0.70 0.07 FALSE
6 GTEx Breast Mammary Tissue (Female) NT5DC2 0.09 0.08 lasso 1 0.06 5.9e-03 5.23 5.2 1.7e-07 -0.13 0.07 0.14 FALSE
7 GTEx Esophagus Gastroesophageal Junction SPCS1 0.13 0.00 lasso 5 0.00 3.1e-01 4.18 5.8 5.9e-09 -0.16 0.08 0.39 FALSE
8 GTEx Esophagus Mucosa TKT 0.07 0.02 enet 12 0.02 2.1e-02 0.92 6.4 2.0e-10 -0.60 0.10 0.68 FALSE
9 GTEx Nerve Tibial RP11-155D18.12 0.25 0.00 enet 26 0.08 4.8e-06 -2.20 5.1 2.8e-07 -0.03 0.02 0.09 TRUE
10 GTEx Pancreas RFT1 0.32 0.13 lasso 4 0.17 1.3e-07 -7.12 -7.3 3.9e-13 0.08 0.88 0.03 TRUE
11 GTEx Skin Not Sun Exposed Suprapubic GNL3 0.07 0.06 lasso 4 0.06 4.5e-04 -4.24 -6.2 5.1e-10 0.00 0.07 0.75 TRUE
12 GTEx Skin Sun Exposed Lower leg TMEM110 0.11 0.06 lasso 3 0.06 1.7e-05 -6.42 6.2 7.7e-10 0.01 0.67 0.02 FALSE
13 GTEx Stomach RFT1 0.23 0.03 enet 19 0.06 6.3e-04 -1.96 -5.3 1.4e-07 -0.02 0.49 0.03 FALSE
14 GTEx Testis TMEM110 0.34 0.24 enet 20 0.25 2.8e-11 -7.16 5.6 2.1e-08 0.06 0.77 0.23 FALSE
15 GTEx Testis ITIH4-AS1 0.23 0.13 enet 12 0.21 8.2e-10 -7.14 6.0 1.5e-09 0.09 0.61 0.39 FALSE
16 GTEx Thyroid DCP1A 0.09 0.05 enet 13 0.05 9.0e-05 -6.90 8.0 1.1e-15 -0.78 0.04 0.91 TRUE
17 GTEx Thyroid TMEM110 0.15 0.09 lasso 3 0.13 3.5e-10 -6.42 5.8 5.4e-09 0.11 0.98 0.01 FALSE
18 METSIM Adipose TMEM110 0.19 0.04 blup 391 0.08 8.8e-12 -2.83 5.6 2.3e-08 0.12 0.97 0.02 FALSE
19 NTR Blood TKT 0.06 0.04 enet 16 0.04 7.8e-13 5.45 -6.1 1.2e-09 0.33 1.00 0.00 TRUE
20 NTR Blood TMEM110 0.02 0.01 blup 391 0.01 1.1e-04 -4.45 -7.1 1.5e-12 0.13 0.90 0.00 FALSE
21 ROSMAP Brain Pre-frontal Cortex ITIH4 0.30 0.19 enet 22 0.27 9.0e-35 -6.42 5.4 6.8e-08 0.13 0.96 0.04 FALSE
22 ROSMAP Brain Pre-frontal Cortex NEK4 0.04 0.05 blup 359 0.05 1.1e-06 5.01 5.7 1.4e-08 -0.22 0.99 0.00 TRUE
23 YFS Blood TKT 0.28 0.25 enet 25 0.29 1.5e-97 4.75 -5.8 9.0e-09 0.28 1.00 0.00 FALSE
24 YFS Blood TMEM110 0.11 0.08 lasso 9 0.09 3.8e-29 -6.24 -6.7 2.8e-11 0.04 0.99 0.01 FALSE
25 The Cancer Genome Atlas Bladder Urothelial Carcinoma RFT1 0.18 0.10 lasso 7 0.10 1.8e-08 -7.14 -7.4 1.1e-13 0.11 0.01 0.99 TRUE
26 The Cancer Genome Atlas Bladder Urothelial Carcinoma TMEM110 0.19 0.13 blup 59 0.13 4.2e-11 -6.65 -7.2 6.9e-13 0.04 0.02 0.98 FALSE
27 The Cancer Genome Atlas Breast Invasive Carcinoma GLT8D1 0.10 0.01 enet 7 0.03 4.4e-06 -5.08 -6.6 4.9e-11 0.06 0.00 0.90 TRUE
28 The Cancer Genome Atlas Breast Invasive Carcinoma RFT1 0.10 0.08 enet 11 0.15 2.3e-29 -7.30 -5.7 1.5e-08 0.07 0.01 0.99 FALSE
29 The Cancer Genome Atlas Breast Invasive Carcinoma SPCS1 0.08 0.04 lasso 2 0.04 4.7e-08 5.00 -5.5 3.3e-08 0.14 0.00 1.00 FALSE
30 The Cancer Genome Atlas Breast Invasive Carcinoma TMEM110 0.13 0.09 lasso 3 0.10 5.9e-20 -6.45 -6.8 1.1e-11 0.03 0.06 0.94 FALSE
31 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma RFT1 0.14 0.08 enet 12 0.15 5.5e-08 -7.15 -5.3 9.8e-08 0.08 0.02 0.98 TRUE
32 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma TMEM110 0.24 0.09 blup 59 0.14 1.4e-07 -6.65 -6.3 3.2e-10 0.17 0.01 0.98 FALSE
33 The Cancer Genome Atlas Colon Adenocarcinoma RFT1 0.10 0.05 enet 12 0.05 1.0e-03 -7.18 -6.0 1.5e-09 0.06 0.01 0.91 FALSE
34 The Cancer Genome Atlas Colon Adenocarcinoma TMEM110 0.21 0.14 lasso 3 0.13 5.1e-08 -5.97 -6.1 1.1e-09 0.01 0.09 0.90 TRUE
35 The Cancer Genome Atlas Esophageal Carcinoma TMEM110 0.35 0.07 enet 18 0.21 3.2e-07 -6.45 -5.7 1.2e-08 0.11 0.03 0.93 FALSE
36 The Cancer Genome Atlas Glioblastoma Multiforme NISCH 0.12 0.00 blup 57 0.05 1.3e-02 -3.80 -5.4 6.8e-08 0.06 0.01 0.26 FALSE
37 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GLT8D1 0.21 0.02 enet 15 0.04 5.8e-05 -5.08 -5.9 4.2e-09 0.07 0.00 0.68 FALSE
38 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMEM110 0.27 0.10 blup 59 0.14 3.0e-15 -6.24 -7.3 2.3e-13 0.04 0.00 1.00 FALSE
39 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TMEM110 0.29 0.16 lasso 6 0.17 1.8e-18 -6.57 -6.8 7.9e-12 0.05 0.03 0.97 FALSE
40 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RFT1 0.24 0.12 lasso 5 0.20 1.3e-11 -7.30 -5.8 7.5e-09 0.06 0.01 0.99 FALSE
41 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TMEM110 0.21 0.10 lasso 4 0.08 2.3e-05 -6.65 -7.1 1.4e-12 0.05 0.03 0.97 FALSE
42 The Cancer Genome Atlas Brain Lower Grade Glioma LOC440957 0.03 0.00 blup 45 0.01 9.8e-03 -3.14 -5.7 9.2e-09 0.08 0.01 0.57 FALSE
43 The Cancer Genome Atlas Brain Lower Grade Glioma NISCH 0.06 0.05 lasso 4 0.04 7.5e-06 -5.25 -5.2 1.9e-07 -0.03 0.00 0.99 FALSE
44 The Cancer Genome Atlas Brain Lower Grade Glioma SFMBT1 0.13 0.03 blup 66 0.07 3.0e-08 -6.45 -6.8 1.5e-11 0.09 0.02 0.98 FALSE
45 The Cancer Genome Atlas Brain Lower Grade Glioma SPCS1 0.15 0.03 lasso 3 0.04 4.3e-05 -5.08 -5.8 5.8e-09 -0.01 0.00 0.88 FALSE
46 The Cancer Genome Atlas Brain Lower Grade Glioma TKT 0.06 0.05 blup 14 0.05 3.4e-06 -7.80 6.7 1.9e-11 -0.77 0.00 1.00 FALSE
47 The Cancer Genome Atlas Brain Lower Grade Glioma TMEM110 0.13 0.06 blup 59 0.08 3.3e-09 -4.53 -6.9 5.2e-12 0.17 0.68 0.32 FALSE
48 The Cancer Genome Atlas Liver Hepatocellular Carcinoma RFT1 0.31 0.07 blup 45 0.19 1.8e-09 -2.32 -6.1 8.6e-10 0.09 0.01 0.99 FALSE
49 The Cancer Genome Atlas Liver Hepatocellular Carcinoma SFMBT1 0.17 0.08 lasso 2 0.06 5.5e-04 -7.18 -7.1 9.3e-13 0.08 0.01 0.94 FALSE
50 The Cancer Genome Atlas Lung Adenocarcinoma RFT1 0.14 0.11 blup 45 0.11 1.9e-12 -7.30 -7.1 1.1e-12 0.06 0.00 1.00 FALSE
51 The Cancer Genome Atlas Lung Adenocarcinoma TMEM110 0.16 0.13 lasso 3 0.12 2.1e-14 -6.45 -6.5 8.8e-11 0.04 0.03 0.97 FALSE
52 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RFT1 0.07 0.03 enet 7 0.06 1.2e-07 -5.94 -5.8 7.3e-09 0.05 0.01 0.99 FALSE
53 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TMEM110 0.19 0.10 lasso 5 0.11 2.1e-12 -6.45 -6.7 2.1e-11 0.12 0.04 0.96 FALSE
54 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RFT1 0.21 0.10 lasso 6 0.23 1.9e-15 -7.11 -5.5 3.6e-08 0.06 0.02 0.98 FALSE
55 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma TMEM110 0.20 0.13 blup 59 0.15 3.0e-10 -7.02 -7.0 3.3e-12 0.13 0.00 1.00 FALSE
56 The Cancer Genome Atlas Pancreatic Adenocarcinoma TMEM110 0.36 0.05 blup 59 0.08 3.4e-04 -6.45 -6.5 8.0e-11 0.14 0.01 0.77 FALSE
57 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TMEM110 0.26 0.09 lasso 4 0.09 1.6e-04 -6.33 -6.5 6.2e-11 0.07 0.05 0.89 TRUE
58 The Cancer Genome Atlas Prostate Adenocarcinoma RFT1 0.18 0.09 blup 45 0.09 4.8e-10 -7.15 -6.8 8.8e-12 0.02 0.01 0.99 FALSE
59 The Cancer Genome Atlas Prostate Adenocarcinoma SFMBT1 0.27 0.07 lasso 7 0.06 2.9e-07 -7.11 -7.1 1.6e-12 0.04 0.02 0.98 FALSE
60 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM110 0.20 0.06 blup 59 0.10 1.2e-10 -7.02 -7.3 2.3e-13 0.10 0.00 1.00 FALSE
61 The Cancer Genome Atlas Soft Tissue Sarcoma RFT1 0.16 0.12 enet 16 0.14 1.7e-08 -7.15 -6.4 1.7e-10 0.06 0.01 0.99 FALSE
62 The Cancer Genome Atlas Soft Tissue Sarcoma TMEM110 0.12 0.07 blup 59 0.12 7.5e-08 -6.45 -7.0 3.6e-12 0.15 0.01 0.99 FALSE
63 The Cancer Genome Atlas Skin Cutaneous Melanoma RFT1 0.29 0.04 blup 45 0.11 8.2e-04 -7.30 -5.9 3.2e-09 0.13 0.01 0.86 FALSE
64 The Cancer Genome Atlas Skin Cutaneous Melanoma TMEM110 0.33 0.15 enet 10 0.16 4.6e-05 -6.57 -5.9 4.4e-09 0.08 0.02 0.75 FALSE
65 The Cancer Genome Atlas Stomach Adenocarcinoma RFT1 0.13 0.05 blup 45 0.10 6.9e-08 -7.18 -6.6 4.7e-11 0.09 0.01 0.99 FALSE
66 The Cancer Genome Atlas Stomach Adenocarcinoma TMEM110 0.19 0.12 blup 59 0.13 1.6e-09 -6.33 -6.9 4.4e-12 0.04 0.02 0.98 FALSE
67 The Cancer Genome Atlas Testicular Germ Cell Tumors RFT1 0.39 0.22 lasso 4 0.25 3.1e-09 -7.28 -7.1 1.1e-12 0.07 0.00 1.00 FALSE
68 The Cancer Genome Atlas Testicular Germ Cell Tumors TMEM110 0.20 0.01 lasso 2 0.09 3.2e-04 -7.02 -7.3 2.7e-13 0.07 0.00 0.93 FALSE
69 The Cancer Genome Atlas Thyroid Carcinoma DCP1A 0.04 0.01 blup 18 0.02 5.1e-03 -6.45 5.9 4.1e-09 -0.69 0.00 0.74 FALSE
70 The Cancer Genome Atlas Thyroid Carcinoma TMEM110 0.09 0.00 blup 59 0.02 1.0e-02 -5.97 -6.5 1.0e-10 0.14 0.02 0.33 FALSE
71 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma RFT1 0.29 0.15 blup 45 0.15 6.5e-05 -5.94 -6.8 1.2e-11 0.12 0.01 0.90 FALSE