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chr3:51,306,844-54,077,726

Best TWAS P=1.14e-15 · Best GWAS P=4.86e-17 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	GTEx	Thyroid	DCP1A	0.09	0.05	enet	13	0.05	9.0e-05	-6.90	8.0	1.1e-15	-0.78	0.04	0.91	TRUE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RFT1	0.18	0.10	lasso	7	0.10	1.8e-08	-7.14	-7.4	1.1e-13	0.11	0.01	0.99	TRUE
10	GTEx	Pancreas	RFT1	0.32	0.13	lasso	4	0.17	1.3e-07	-7.12	-7.3	3.9e-13	0.08	0.88	0.03	TRUE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	GLT8D1	0.10	0.01	enet	7	0.03	4.4e-06	-5.08	-6.6	4.9e-11	0.06	0.00	0.90	TRUE
57	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TMEM110	0.26	0.09	lasso	4	0.09	1.6e-04	-6.33	-6.5	6.2e-11	0.07	0.05	0.89	TRUE
11	GTEx	Skin Not Sun Exposed Suprapubic	GNL3	0.07	0.06	lasso	4	0.06	4.5e-04	-4.24	-6.2	5.1e-10	0.00	0.07	0.75	TRUE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM110	0.21	0.14	lasso	3	0.13	5.1e-08	-5.97	-6.1	1.1e-09	0.01	0.09	0.90	TRUE
19	NTR	Blood	TKT	0.06	0.04	enet	16	0.04	7.8e-13	5.45	-6.1	1.2e-09	0.33	1.00	0.00	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	NEK4	0.04	0.05	blup	359	0.05	1.1e-06	5.01	5.7	1.4e-08	-0.22	0.99	0.00	TRUE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RFT1	0.14	0.08	enet	12	0.15	5.5e-08	-7.15	-5.3	9.8e-08	0.08	0.02	0.98	TRUE
9	GTEx	Nerve Tibial	RP11-155D18.12	0.25	0.00	enet	26	0.08	4.8e-06	-2.20	5.1	2.8e-07	-0.03	0.02	0.09	TRUE
1	CommonMind	Brain Pre-frontal Cortex	GNL3	0.15	0.07	bslmm	390	0.08	1.3e-09	-4.24	5.1	3.1e-07	0.02	0.97	0.02	TRUE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM110	0.27	0.10	blup	59	0.14	3.0e-15	-6.24	-7.3	2.3e-13	0.04	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM110	0.20	0.06	blup	59	0.10	1.2e-10	-7.02	-7.3	2.3e-13	0.10	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TMEM110	0.20	0.01	lasso	2	0.09	3.2e-04	-7.02	-7.3	2.7e-13	0.07	0.00	0.93	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TMEM110	0.19	0.13	blup	59	0.13	4.2e-11	-6.65	-7.2	6.9e-13	0.04	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SFMBT1	0.17	0.08	lasso	2	0.06	5.5e-04	-7.18	-7.1	9.3e-13	0.08	0.01	0.94	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	RFT1	0.14	0.11	blup	45	0.11	1.9e-12	-7.30	-7.1	1.1e-12	0.06	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RFT1	0.39	0.22	lasso	4	0.25	3.1e-09	-7.28	-7.1	1.1e-12	0.07	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM110	0.21	0.10	lasso	4	0.08	2.3e-05	-6.65	-7.1	1.4e-12	0.05	0.03	0.97	FALSE
20	NTR	Blood	TMEM110	0.02	0.01	blup	391	0.01	1.1e-04	-4.45	-7.1	1.5e-12	0.13	0.90	0.00	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	SFMBT1	0.27	0.07	lasso	7	0.06	2.9e-07	-7.11	-7.1	1.6e-12	0.04	0.02	0.98	FALSE
55	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM110	0.20	0.13	blup	59	0.15	3.0e-10	-7.02	-7.0	3.3e-12	0.13	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Soft Tissue Sarcoma	TMEM110	0.12	0.07	blup	59	0.12	7.5e-08	-6.45	-7.0	3.6e-12	0.15	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM110	0.19	0.12	blup	59	0.13	1.6e-09	-6.33	-6.9	4.4e-12	0.04	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM110	0.13	0.06	blup	59	0.08	3.3e-09	-4.53	-6.9	5.2e-12	0.17	0.68	0.32	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM110	0.29	0.16	lasso	6	0.17	1.8e-18	-6.57	-6.8	7.9e-12	0.05	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	RFT1	0.18	0.09	blup	45	0.09	4.8e-10	-7.15	-6.8	8.8e-12	0.02	0.01	0.99	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM110	0.13	0.09	lasso	3	0.10	5.9e-20	-6.45	-6.8	1.1e-11	0.03	0.06	0.94	FALSE
71	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RFT1	0.29	0.15	blup	45	0.15	6.5e-05	-5.94	-6.8	1.2e-11	0.12	0.01	0.90	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	SFMBT1	0.13	0.03	blup	66	0.07	3.0e-08	-6.45	-6.8	1.5e-11	0.09	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	TKT	0.06	0.05	blup	14	0.05	3.4e-06	-7.80	6.7	1.9e-11	-0.77	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM110	0.19	0.10	lasso	5	0.11	2.1e-12	-6.45	-6.7	2.1e-11	0.12	0.04	0.96	FALSE
24	YFS	Blood	TMEM110	0.11	0.08	lasso	9	0.09	3.8e-29	-6.24	-6.7	2.8e-11	0.04	0.99	0.01	FALSE
65	The Cancer Genome Atlas	Stomach Adenocarcinoma	RFT1	0.13	0.05	blup	45	0.10	6.9e-08	-7.18	-6.6	4.7e-11	0.09	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM110	0.36	0.05	blup	59	0.08	3.4e-04	-6.45	-6.5	8.0e-11	0.14	0.01	0.77	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM110	0.16	0.13	lasso	3	0.12	2.1e-14	-6.45	-6.5	8.8e-11	0.04	0.03	0.97	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM110	0.09	0.00	blup	59	0.02	1.0e-02	-5.97	-6.5	1.0e-10	0.14	0.02	0.33	FALSE
61	The Cancer Genome Atlas	Soft Tissue Sarcoma	RFT1	0.16	0.12	enet	16	0.14	1.7e-08	-7.15	-6.4	1.7e-10	0.06	0.01	0.99	FALSE
8	GTEx	Esophagus Mucosa	TKT	0.07	0.02	enet	12	0.02	2.1e-02	0.92	6.4	2.0e-10	-0.60	0.10	0.68	FALSE
32	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM110	0.24	0.09	blup	59	0.14	1.4e-07	-6.65	-6.3	3.2e-10	0.17	0.01	0.98	FALSE
12	GTEx	Skin Sun Exposed Lower leg	TMEM110	0.11	0.06	lasso	3	0.06	1.7e-05	-6.42	6.2	7.7e-10	0.01	0.67	0.02	FALSE
48	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RFT1	0.31	0.07	blup	45	0.19	1.8e-09	-2.32	-6.1	8.6e-10	0.09	0.01	0.99	FALSE
15	GTEx	Testis	ITIH4-AS1	0.23	0.13	enet	12	0.21	8.2e-10	-7.14	6.0	1.5e-09	0.09	0.61	0.39	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	RFT1	0.10	0.05	enet	12	0.05	1.0e-03	-7.18	-6.0	1.5e-09	0.06	0.01	0.91	FALSE
63	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RFT1	0.29	0.04	blup	45	0.11	8.2e-04	-7.30	-5.9	3.2e-09	0.13	0.01	0.86	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	DCP1A	0.04	0.01	blup	18	0.02	5.1e-03	-6.45	5.9	4.1e-09	-0.69	0.00	0.74	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GLT8D1	0.21	0.02	enet	15	0.04	5.8e-05	-5.08	-5.9	4.2e-09	0.07	0.00	0.68	FALSE
64	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TMEM110	0.33	0.15	enet	10	0.16	4.6e-05	-6.57	-5.9	4.4e-09	0.08	0.02	0.75	FALSE
17	GTEx	Thyroid	TMEM110	0.15	0.09	lasso	3	0.13	3.5e-10	-6.42	5.8	5.4e-09	0.11	0.98	0.01	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPCS1	0.15	0.03	lasso	3	0.04	4.3e-05	-5.08	-5.8	5.8e-09	-0.01	0.00	0.88	FALSE
7	GTEx	Esophagus Gastroesophageal Junction	SPCS1	0.13	0.00	lasso	5	0.00	3.1e-01	4.18	5.8	5.9e-09	-0.16	0.08	0.39	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RFT1	0.07	0.03	enet	7	0.06	1.2e-07	-5.94	-5.8	7.3e-09	0.05	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RFT1	0.24	0.12	lasso	5	0.20	1.3e-11	-7.30	-5.8	7.5e-09	0.06	0.01	0.99	FALSE
23	YFS	Blood	TKT	0.28	0.25	enet	25	0.29	1.5e-97	4.75	-5.8	9.0e-09	0.28	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC440957	0.03	0.00	blup	45	0.01	9.8e-03	-3.14	-5.7	9.2e-09	0.08	0.01	0.57	FALSE
35	The Cancer Genome Atlas	Esophageal Carcinoma	TMEM110	0.35	0.07	enet	18	0.21	3.2e-07	-6.45	-5.7	1.2e-08	0.11	0.03	0.93	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	RFT1	0.10	0.08	enet	11	0.15	2.3e-29	-7.30	-5.7	1.5e-08	0.07	0.01	0.99	FALSE
14	GTEx	Testis	TMEM110	0.34	0.24	enet	20	0.25	2.8e-11	-7.16	5.6	2.1e-08	0.06	0.77	0.23	FALSE
18	METSIM	Adipose	TMEM110	0.19	0.04	blup	391	0.08	8.8e-12	-2.83	5.6	2.3e-08	0.12	0.97	0.02	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPCS1	0.08	0.04	lasso	2	0.04	4.7e-08	5.00	-5.5	3.3e-08	0.14	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	TMEM110	0.12	0.05	lasso	6	0.03	7.3e-04	-6.42	5.5	3.6e-08	0.06	0.27	0.06	FALSE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFT1	0.21	0.10	lasso	6	0.23	1.9e-15	-7.11	-5.5	3.6e-08	0.06	0.02	0.98	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	ITIH4	0.30	0.19	enet	22	0.27	9.0e-35	-6.42	5.4	6.8e-08	0.13	0.96	0.04	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	NISCH	0.12	0.00	blup	57	0.05	1.3e-02	-3.80	-5.4	6.8e-08	0.06	0.01	0.26	FALSE
5	GTEx	Breast Mammary Tissue	NT5DC2	0.13	0.12	enet	11	0.08	9.9e-05	5.23	5.3	1.4e-07	-0.19	0.70	0.07	FALSE
13	GTEx	Stomach	RFT1	0.23	0.03	enet	19	0.06	6.3e-04	-1.96	-5.3	1.4e-07	-0.02	0.49	0.03	FALSE
6	GTEx	Breast Mammary Tissue (Female)	NT5DC2	0.09	0.08	lasso	1	0.06	5.9e-03	5.23	5.2	1.7e-07	-0.13	0.07	0.14	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TKT	0.06	0.05	enet	12	0.03	2.7e-04	4.16	5.2	1.8e-07	-0.32	0.98	0.01	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	NISCH	0.06	0.05	lasso	4	0.04	7.5e-06	-5.25	-5.2	1.9e-07	-0.03	0.00	0.99	FALSE
4	GTEx	Brain Frontal Cortex BA9	GNL3	0.14	0.15	enet	10	0.13	2.3e-04	4.13	5.1	2.8e-07	-0.16	0.20	0.06	FALSE