TWAS hub - DCP1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.268	0.090	0.00140	-0.005	NA	-0.004	NA	-0.009	0.50000	NA	4.6e-01	NA	0.88000
2	GTEx	Liver	0.200	0.096	0.00530	0.014	NA	-0.010	NA	0.024	0.13000	NA	8.5e-01	NA	0.06900
3	GTEx	Thyroid	0.094	0.040	0.00520	0.049	NA	0.051	NA	0.038	0.00012	NA	9.0e-05	NA	0.00070
4	TCGA	Soft Tissue Sarcoma	0.095	0.076	0.00041	0.035	0.060	0.069	NA	0.055	0.00360	0.00018	6.2e-05	NA	0.00035
5	TCGA	Thyroid Carcinoma	0.037	0.027	0.00690	0.013	0.019	0.010	NA	0.010	0.01700	0.00510	3.5e-02	NA	0.03400

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4	5
Pulse rate, automated reading	7.4	24.0	64.2	3.1	8.0	-3.5	5.9
Pulse rate	5.6	9.4	18.3	3.4	4.3	-2.3	3.4
Bipolar Disorder or Schizophrenia	5.4	13.1	33.3	5.8	4.1	-2.5	3.1
Worrier / anxious feelings	5.4	10.3	35.9	6.0	2.5	-2.6	1.6
Schizophrenia (2014)	4.9	10.7	24.9	5.0	4.0	-1.1	3.4
Bipolar Disorder (2018)	4.0	6.3	15.4	3.9	3.0	-1.6	2.1
Bipolar Disorder (2011)	4.0	3.9	10.2	3.2	1.7	-2.1	1.4
Guilty feelings	3.8	5.8	14.6	2.7	3.8	-1.9	1.9
Worry (Nagel 2018)	3.6	7.7	29.8	5.5	1.2	-2.4	1.0
Schizophrenia (2018)	3.3	6.9	18.1	4.3	2.8	-1.9	2.2
Neuroticism	3.3	7.8	16.3	4.0	3.3	-2.6	2.4
Sensitivity / hurt feelings	3.1	5.3	13.6	1.8	3.7	-1.0	3.0
Ulcerative Colitis	3.0	4.4	10.0	3.2	0.1	3.1	1.5
Qualifications: College or University degree	3.0	9.4	18.1	3.1	4.2	-1.7	4.0
Headache pain in last month	2.8	4.9	14.4	3.8	1.7	-0.6	2.6
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.3	9.8	3.1	1.8	-1.8	2.2
Eye problems/disorders: None of the above	2.7	3.2	9.1	-2.1	-1.4	-0.6	-3.0
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	8.7	-1.4	-3.0	-0.2	-2.4
Neuroticism (Nagel 2018)	2.5	5.8	14.5	3.8	2.4	-2.6	1.4
Gout (self-reported)	2.5	3.4	8.5	2.8	0.8	-0.1	2.9
Wears glasses or contact lenses	2.5	2.9	10.0	-0.8	-1.0	-3.2	-1.7
Verbal and Numeric Reasoning (VNR)	2.4	5.8	20.4	-4.5	-0.6	-1.7	-2.3
Neuroticism score	2.4	5.1	8.7	3.0	2.4	-2.2	2.5
Eye problems/disorders: Cataract	2.4	2.8	6.6	2.2	1.4	0.8	2.6
Supplements: Fish oil (including cod liver oil)	2.4	3.2	8.4	-1.6	-2.9	1.6	-1.6
Multivitamins +/- minerals	2.3	2.9	5.0	-2.2	-1.4	-1.7	-2.2
Falls in the last year	2.3	3.2	10.3	0.6	1.9	1.2	3.2
Depression (self-reported)	2.3	2.7	9.8	3.1	0.8	-0.6	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	7.2	2.7	1.2	-2.7	1.3
Eye problems/disorders: Glaucoma	2.3	2.8	7.7	1.5	1.5	1.4	2.8
Major Depression (MDD)	2.2	2.7	8.0	2.8	1.9	-0.2	1.4
Neuroticism (2016)	2.2	3.2	10.4	3.2	1.6	-1.1	1.4
Mineral and other dietary supplements	2.2	3.0	5.4	2.3	2.2	-0.9	2.0
Smoking Status	2.1	5.0	16.2	-4.0	-2.3	1.6	-1.1
Average weekly spirits intake	2.1	2.6	5.4	-2.0	-2.3	1.2	-1.5
Financial difficulties in last 2 years	2.1	2.8	5.1	0.2	2.2	2.3	2.0
Fluid intelligence score	2.1	4.4	14.7	-3.8	0.0	-2.1	-1.6
Worry too long after embarrassment	2.1	3.5	6.1	2.3	2.3	-0.8	2.5
Nervous feelings	2.0	3.8	12.5	3.5	1.5	-1.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.5	2.1	2.0	-1.3	1.1
Ever highly irritable/argumentative for 2 days	2.0	2.4	5.6	-2.4	-1.2	-2.0	-0.9
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.5	-1.3	-1.1	-2.0	-2.1
Back pain experienced in last month	2.0	3.0	7.5	-1.6	-2.7	-1.2	-1.8
Irritable Bowel Disease (IBD)	1.9	4.4	9.6	3.1	0.7	3.1	1.6
Migraine (self-reported)	1.9	2.4	5.7	2.4	1.6	0.7	1.8
Smoking status: Previous	1.9	2.8	7.1	-2.7	-1.6	2.0	-0.1
Hearing aid user	1.9	2.2	4.9	-2.2	-1.6	0.8	-1.6
Ulcerative Colitis (UC)	1.8	3.4	7.0	2.7	0.6	2.4	2.0
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	6.9	1.5	1.5	0.6	2.6
Medication: Amlodipine	1.8	2.5	8.0	1.4	1.3	0.9	2.8
Commuting to job workplace: Car/motor vehicle	1.8	2.1	4.3	1.2	1.4	-2.1	1.6
Qualifications: nursing, teaching	1.8	2.8	12.7	-0.1	1.0	-3.6	0.5
Intelligence (Savage-Jansen 2018)	1.7	5.3	20.9	-4.6	-0.8	-1.4	-1.8
Townsend deprivation index at recruitment	1.7	2.4	9.3	-3.0	0.6	1.4	-0.5
Happiness	1.7	2.1	6.5	1.8	-0.7	-2.5	-0.4
Knee pain experienced in last month	1.7	2.6	6.2	-1.9	-2.5	0.9	-1.6
Friendships satisfaction	1.7	2.1	4.1	1.6	-1.0	-2.0	-1.7
Type 2 Diabetes (T2D) (2012)	1.6	1.9	5.8	-2.4	-0.6	1.6	-0.8
Maternal smoking around birth	1.6	2.3	8.0	-0.8	0.5	2.8	1.6
Stomach or abdominal pain in last month	1.6	1.9	6.6	2.6	0.4	-1.2	1.2
Risk taking	1.6	2.3	6.3	0.2	0.7	2.5	2.2
Ever had prostate specific antigen (PSA) test	1.6	1.8	7.6	0.4	-2.8	0.4	-1.0
Past tobacco smoking	1.5	2.7	8.7	3.0	1.1	-1.9	-0.2
Exposure to tobacco smoke at home	1.5	1.7	3.5	1.5	1.6	-0.4	1.9
Ever depressed for a whole week	1.5	1.8	9.0	0.2	-0.0	-3.0	0.5
Age at First Birth	1.4	2.0	6.0	-1.5	1.0	-2.4	-0.9
LDL Cholesterol	1.4	2.2	8.3	-2.9	-0.5	-0.1	-1.5
Diabetes (father)	1.4	1.7	5.3	-2.3	-1.2	-0.7	-1.1
Number of incorrect matches in round	1.4	2.4	11.4	3.4	0.4	-0.1	0.5
Impedance of arm (left)	1.4	6.4	21.4	2.2	-0.3	-4.6	-2.3
Length of working week for main job	1.4	1.5	5.6	-0.9	-0.9	2.4	0.7
Loneliness, isolation	1.4	1.9	4.8	1.3	1.7	0.0	2.2
Primary Biliary Cirrhosis	1.3	1.9	3.4	-1.7	-1.8	0.3	-1.7
Hand grip strength (left)	1.3	3.4	10.6	3.2	1.3	-2.1	-0.5
Impedance of arm (right)	1.3	5.9	17.4	2.5	-0.4	-4.2	-2.4
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.0	4.5	2.0	0.7	-2.1	1.0
Asthma	1.3	2.6	10.0	-1.2	-0.9	-3.2	-0.8
Peak expiratory flow (PEF)	1.3	3.1	9.1	-0.4	-3.0	-0.2	-2.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.4	1.5	0.6	2.1	1.1
Suffer from ‘nerves’	1.3	2.0	7.4	2.7	0.7	-1.4	0.4
Family relationship satisfaction	1.3	1.6	4.6	2.1	1.2	-0.8	1.1
Miserableness	1.3	2.3	6.4	0.8	1.8	-2.5	1.0
Ever taken oral contraceptive pill	1.3	1.5	4.6	-0.6	1.4	0.6	2.1
Alcohol drinker status: Never	1.3	1.6	4.4	2.1	0.9	0.5	1.6
Coronary Artery Disease (CAD)	1.2	1.4	2.8	1.0	1.7	0.8	1.7
Lupus	1.2	1.8	3.3	0.1	1.8	1.7	1.7
Waist Hip Ratio (WHR)	1.2	5.4	17.9	2.0	4.2	-1.5	1.6
Cardiovascular Disease	1.2	3.9	8.4	-2.3	-2.9	2.3	-0.3
Type 2 Diabetes (T2D) (2018)	1.2	2.2	9.2	-3.0	-0.4	1.3	0.2
Lung FEV1/FVC ratio	1.2	6.0	21.9	-1.6	-4.7	-0.4	-2.3
Relative age of first facial hair	1.2	2.5	7.3	-0.1	2.7	1.2	2.0
High blood pressure (mother)	1.2	1.6	3.4	1.7	1.2	0.6	1.9
Had other major operations	1.2	1.5	3.9	-0.7	-1.5	-2.0	-0.9
Allergy	1.2	2.7	7.5	-1.1	-1.3	1.8	-2.7
Emphysema/chronic bronchitis	1.2	1.3	3.0	1.7	1.5	-0.6	1.0
Osteoarthritis (self-reported)	1.2	1.5	2.9	-1.1	-1.7	-1.1	-1.5
Impedance of whole body	1.2	6.2	18.9	2.6	0.6	-4.3	-2.2
Depression (Nagel 2018)	1.1	1.6	3.4	1.9	1.0	-1.8	0.3
BMI	1.1	6.4	22.1	-4.7	-1.4	2.4	1.5
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.0	2.0	1.1	-1.3	1.0
Diabetes (mother)	1.1	1.5	3.5	-0.2	1.9	-0.8	1.8
Prospective memory result	1.1	1.3	5.4	2.3	1.0	-0.4	0.1
Pulse wave reflection index	1.1	1.3	3.2	-1.8	-1.3	1.3	0.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	5.8	0.4	0.9	-2.4	-0.5
Leg pain on walking	1.1	1.4	4.5	-0.1	1.2	0.9	2.1
Asthma (self-reported)	1.1	2.3	9.1	-1.1	-0.8	-3.0	-0.6
Pain experienced in last month	1.1	1.8	3.4	1.2	1.9	1.5	1.4
Systolic blood pressure, automated reading	1.0	2.9	7.1	-0.7	-2.7	2.6	-0.4
Vitamin and mineral supplements	1.0	1.4	2.2	0.6	1.5	1.5	1.4
Impedance of leg (right)	1.0	5.1	16.0	1.9	1.7	-4.0	-1.6
Hand grip strength (right)	1.0	2.8	7.0	2.3	0.0	-2.6	-1.3
Average weekly fortified wine intake	1.0	1.2	3.1	1.8	1.4	-0.3	0.8
Qualifications: None of the above	1.0	2.1	5.7	-1.6	-2.4	1.0	-1.2
Hair/balding pattern: Pattern 4	1.0	2.4	6.9	-2.6	-0.7	0.1	-2.1
Loud music exposure frequency	1.0	1.1	2.3	1.1	1.5	1.2	0.9
Medication: Omeprazole	1.0	1.2	4.6	0.8	0.7	-0.3	2.2
Illnesses of siblings: Diabetes	1.0	1.2	4.2	-0.5	-2.0	0.2	-1.3
Ever had bowel cancer screening	1.0	1.2	4.8	0.6	-2.2	0.7	-0.5
Diabetes diagnosed by doctor	1.0	1.7	8.1	-2.9	-0.2	0.4	0.5
Fractured/broken bones in last 5 years	1.0	1.2	5.0	0.3	0.3	2.2	1.0
Cholesterol lowering medication	1.0	1.4	6.1	0.1	-0.1	2.5	1.0
Alzheimer’s Disease (in mother)	0.9	1.1	3.8	0.6	1.9	-0.1	1.2
Blood Red Count	0.9	8.3	26.9	5.2	1.2	2.6	2.5
Chronotype (morning person)	0.9	2.1	4.7	-2.2	-2.1	-0.3	-1.1
Fed-up feelings	0.9	1.6	3.6	0.8	1.6	-1.9	1.2
Serious illness, injury or assault to yourself	0.9	1.0	2.7	1.7	1.2	-0.6	0.9
Body mass index (BMI)	0.9	3.9	7.2	-2.6	-0.6	2.7	2.2
Pain all over the body in last month	0.9	1.0	2.8	-0.9	-1.2	-1.7	-0.0
Diabetes (self-reported)	0.9	1.3	6.1	-2.5	-0.5	0.0	0.6
Medication: Ramipril	0.9	1.2	4.1	-0.7	-2.0	1.0	-0.4
Illnesses of siblings	0.9	1.3	3.7	-0.4	1.6	-1.9	0.5
Number of full brothers	0.9	1.2	2.5	-1.3	1.6	0.0	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	3.5	-0.9	-1.9	-0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	8.5	2.9	0.5	-0.7	0.6
Ever smoked	0.9	1.6	6.2	-2.5	-0.0	1.3	0.4
Depressed Affect (Nagel 2018)	0.8	1.7	4.2	1.6	1.2	-2.0	0.6
Mean Putamen Volume	0.8	0.9	2.8	1.0	1.7	0.4	0.8
Triglycerides	0.8	1.2	4.0	-1.0	-2.0	0.1	-1.1
Blood Eosinophil Count	0.8	6.0	19.7	-4.4	-1.5	-2.8	0.6
Height	0.8	14.8	60.8	7.8	-2.1	-1.4	-2.6
Respiratory disease	0.8	1.8	7.9	-0.7	-0.8	-2.8	0.5
Severe depression (siblings)	0.8	0.9	1.9	0.9	1.3	-1.4	0.6
Sitting height	0.8	5.7	26.3	5.1	-1.1	-0.1	-0.9
Mouth/teeth dental problems	0.8	1.3	3.0	-0.1	-1.6	-1.0	-1.7
Hair/balding pattern: Pattern 3	0.8	1.2	3.2	-1.0	-1.2	-1.8	-0.3
Breastfed as a baby	0.8	1.0	1.6	-1.3	-1.1	-1.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.3	1.8	0.1	-1.4	-0.0
Number of children fathered	0.8	0.9	1.9	-1.1	-1.1	0.3	-1.4
Medication: Allopurinol	0.8	1.0	2.5	1.4	0.6	0.6	1.6
Mean time to correctly identify matches	0.8	1.5	5.3	-1.2	-2.3	0.1	-0.9
Number of full sisters	0.8	1.0	2.3	0.2	1.0	1.5	1.2
Medication: Aspirin	0.8	1.0	3.2	0.8	-0.2	1.8	1.1
Illnesses of father: Heart disease	0.8	1.1	4.2	0.7	-2.0	0.5	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.8	-0.8	-1.3	1.1	-0.6
Medication: Aspirin	0.8	1.1	3.6	0.9	-0.6	1.9	0.8
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.7	1.0	1.1	1.6	0.3
Medication: Bendroflumethiazide	0.8	1.2	3.1	-1.4	-1.7	0.4	-0.9
Medication: Paracetamol	0.8	1.2	2.9	1.7	0.7	0.2	1.7
Illnesses of father: High blood pressure	0.8	1.0	1.9	1.4	-0.8	0.9	1.3
Average weekly beer plus cider intake	0.8	1.2	4.2	1.1	0.8	0.1	2.1
Prostate Cancer	0.7	1.0	2.2	0.7	-1.5	0.9	-1.2
Rheumatoid Arthritis	0.7	1.0	2.1	-1.3	-1.4	-0.5	-0.9
Systolic Blood Pressure	0.7	3.3	9.1	-1.8	-3.0	1.7	-1.2
Number of treatments/medications taken	0.7	1.3	3.1	-0.0	-1.8	1.2	1.4
Medication: Metformin	0.7	0.9	1.8	-1.1	0.7	1.1	1.3
Hayfever, allergic rhinitis or eczema	0.7	1.6	5.2	1.1	1.3	-0.2	2.3
Impedance of leg (left)	0.7	3.4	8.2	1.9	1.3	-2.9	-1.9
Number of live births	0.7	1.0	2.2	0.9	1.5	-0.5	1.4
Noisy workplace	0.7	0.8	3.0	-0.6	-1.7	-0.0	-0.8
Standing height	0.7	6.8	28.1	5.3	-0.2	-1.7	-1.6
Tense / ‘highly strung’	0.7	1.2	4.4	2.1	-1.0	0.5	-0.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.9	-0.0	0.6	-2.2	-0.3
Medication: Seretide 50 evohaler	0.7	0.8	3.4	0.4	1.8	-0.4	0.7
Chest pain or discomfort	0.7	1.1	3.7	1.9	0.5	-0.3	1.1
Hypertension (Self-reported)	0.7	2.0	6.8	-0.9	-2.6	1.6	-0.0
Illnesses of father: None of the above (group 1)	0.7	0.9	3.6	-0.2	1.9	-0.8	-0.6
Age started oral contraceptive pill	0.7	0.9	3.1	1.1	-0.4	-1.8	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.6	1.1	0.0	-0.6	1.6
Heart disease (siblings)	0.7	0.8	1.7	1.0	0.5	1.3	1.1
Alzheimer’s Disease (including proxy)	0.6	0.9	3.5	0.5	1.9	0.1	0.9
HbA1C	0.6	0.7	1.5	-0.8	-1.2	1.0	-0.2
Age when periods started (menarche)	0.6	1.5	4.2	-1.1	0.1	-2.1	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.0	-2.0	-0.9	0.9	1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.1	0.1	0.6	-1.8	-0.1
Alcohol usually taken with meals	0.6	1.0	3.9	2.0	-0.5	-0.1	-1.0
Had menopause	0.6	0.8	2.5	-0.5	-1.0	0.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	4.7	-2.2	-1.6	0.2	0.3
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.0	0.3	0.2	-1.4	1.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.0	1.2	-1.4	0.9	0.2
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.4	1.1	1.1	-2.1	0.3
Illnesses of mother	0.6	0.7	1.5	-1.0	-1.0	-0.4	-1.2
High blood pressure (siblings)	0.6	0.9	3.0	-0.2	-1.7	1.1	-0.4
Wheeze or whistling in the chest in last year	0.6	1.1	2.1	1.1	0.5	-1.4	1.4
Pulse wave peak to peak time	0.6	0.7	2.5	1.0	-0.3	-1.6	-0.4
Comparative height size at age 10	0.6	3.4	11.0	3.3	-0.0	-1.8	-1.7
Average weekly red wine intake	0.6	0.9	2.6	-0.5	-1.6	1.2	-0.2
Osteoporosis (self-reported)	0.6	0.8	1.9	0.8	1.4	-0.9	0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.9	-0.4	0.7	1.2	1.4
Medication: Atorvastatin	0.6	0.7	1.5	0.6	-1.1	1.2	0.5
Diastolic blood pressure, automated reading	0.6	2.0	5.9	1.6	0.9	0.8	2.4
Basal cell carcinoma (self-reported)	0.6	0.7	2.2	1.2	0.1	1.5	-0.2
Schizophrenia vs Biploar Disorder	0.5	0.6	1.7	0.3	1.0	0.6	1.3
Crohns Disease (2017)	0.5	1.2	3.1	1.8	-0.1	1.6	0.3
Fasting Glucose	0.5	0.6	2.1	0.2	-0.1	1.0	1.4
HDL Cholesterol	0.5	0.8	2.4	0.9	0.5	-1.5	-0.8
Hearing difficulty/problems: Yes	0.5	0.8	2.7	-1.0	-0.3	1.7	0.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	0.1	-0.0	1.0	1.3
Medication: Co-codamol	0.5	0.6	1.6	-0.6	0.8	-1.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.5	1.2	0.8	-1.1	0.2
Taking other prescription medications	0.5	0.8	1.5	0.5	-0.9	-1.1	1.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.3	-0.4	-0.3	1.1	-1.0
High blood pressure	0.5	1.4	4.4	-0.6	-2.1	1.5	0.0
Chronic bronchitis/emphysema (father)	0.5	0.5	2.5	-0.1	-0.3	-1.6	0.2
Waist circumference	0.5	1.7	5.8	0.0	1.0	1.3	2.4
Hearing difficulty/problems with background noise	0.5	0.8	1.6	0.6	0.8	1.3	1.1
Father’s age at death	0.5	0.7	3.2	0.2	1.8	0.1	0.2
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	-0.8	0.3	1.4	0.2
Forced vital capacity (FVC), Best measure	0.5	1.8	9.0	3.0	-0.0	-0.2	0.3
Comparative body size at age 10	0.5	1.4	5.8	-2.4	0.3	-0.9	-0.5
Medication: Blood pressure	0.5	0.8	2.4	-0.3	-0.9	1.6	0.9
Overall health rating	0.5	1.2	5.6	0.4	0.1	-2.4	0.1
Long-standing illness, disability or infirmity	0.5	0.8	2.0	-0.7	-1.1	0.5	1.4
Commuting to job workplace: Walk	0.5	0.5	1.6	-0.7	-0.5	1.3	-0.7
Smoking status: Current	0.5	0.7	2.9	-1.7	-0.5	-0.0	-0.7
Number of self-reported non-cancer illnesses	0.5	0.9	2.4	1.1	-1.5	-0.7	0.7
Leg fat percentage (left)	0.5	1.8	5.1	-2.2	-0.4	1.6	1.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.3	0.1	1.8	-1.6	-0.8
Supplements: Calcium	0.5	0.5	1.3	-0.3	-0.6	-1.1	-0.9
Breast Cancer	0.4	0.9	2.6	-0.7	1.1	-0.1	1.6
Heel T-Score	0.4	3.6	15.8	-4.0	-0.8	0.6	1.0
Medication for hormone replacement therapy	0.4	0.5	1.7	-0.8	-0.1	-1.3	0.2
Supplements: Zinc	0.4	0.4	1.1	-0.7	0.1	-1.0	-0.7
Pack years adult smoking proportion	0.4	0.7	2.5	0.3	-0.0	1.6	0.9
Current tobacco smoking	0.4	0.7	2.6	-1.6	-0.3	0.1	-0.8
Relative age voice broke	0.4	0.6	3.1	-1.8	-0.2	0.1	0.1
Hair/balding pattern: Pattern 2	0.4	0.6	1.4	-0.8	-0.8	-1.2	-0.2
Forced vital capacity (FVC)	0.4	1.4	5.6	2.4	-0.8	-0.1	-0.8
Alcohol intake versus 10 years previously	0.4	0.7	2.2	-1.5	-0.1	-1.0	-0.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.5	1.6	-1.9	-0.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.2	2.0	-1.4	-0.1	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.5	0.2	-0.2	-1.2	1.1
Medication: Paracetamol	0.4	0.6	2.7	1.6	0.2	-0.1	0.7
Glaucoma (self-reported)	0.4	0.5	1.2	0.7	0.9	0.4	1.1
Birth weight	0.4	1.0	4.3	2.1	0.1	-0.7	-0.1
Exposure to tobacco smoke outside home	0.4	0.6	1.4	0.3	1.2	-0.5	1.1
Health satisfaction	0.4	0.6	2.1	-0.7	-1.5	-0.2	-0.4
Medication for pain relief, constipation, heartburn	0.4	0.6	1.4	-1.2	1.2	-0.5	-0.4
Age at last live birth	0.4	0.6	2.3	0.3	0.8	1.5	0.0
Supplements: Vitamin C	0.4	0.5	1.3	0.5	-0.5	-1.1	-0.9
Mood swings	0.4	0.7	1.9	1.4	0.5	-0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.1	0.4	-1.8	-0.8	-0.1
Mother’s age at death	0.4	0.5	1.7	-0.0	0.4	-0.7	-1.3
Financial situation satisfaction	0.4	0.4	1.0	-0.7	0.0	1.0	0.8
Arm fat-free mass (left)	0.4	2.0	7.7	0.8	-0.2	2.8	1.3
Myopia	0.4	0.7	2.9	-1.7	-0.0	-0.6	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	0.0	-0.2	-1.3	0.8
Alcohol drinker status: Previous	0.4	0.5	2.1	-0.3	-1.5	0.5	0.3
Pack years of smoking	0.4	0.5	1.9	0.3	-0.4	1.4	0.7
Leg fat mass (left)	0.4	1.6	3.6	-1.5	-0.6	1.9	1.3
Arm predicted mass (left)	0.4	2.1	8.2	0.6	-0.3	2.9	1.4
Reaction Time	0.3	0.6	1.7	-1.0	-1.3	0.1	-0.1
Ovarian Cancer	0.3	0.4	1.3	-0.6	-0.2	1.1	-0.6
Crohns Disease (2012)	0.3	0.4	1.4	1.2	0.4	0.8	-0.0
Tanning	0.3	3.9	15.0	-3.9	-1.7	-0.0	-1.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.2	-1.1	-0.1	0.9	-0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.7	0.6	0.6	0.7
Medication: Atenolol	0.3	0.3	0.6	-0.7	-0.7	-0.8	0.2
Medication: Levothyroxine sodium	0.3	0.6	1.1	1.0	0.2	-0.8	1.1
Arm fat percentage (right)	0.3	1.4	3.0	-1.5	-0.7	1.1	1.7
Trunk fat-free mass	0.3	1.9	6.3	1.5	-0.2	2.5	0.9
Hip circumference	0.3	1.4	3.6	-0.3	-1.3	1.9	1.3
Time employed in main current job	0.3	0.4	0.9	-0.9	-1.0	0.0	0.5
Mouth/teeth dental problems: Dentures	0.3	0.4	1.7	-0.1	0.6	0.5	1.3
Medication: Lansoprazole	0.3	0.4	1.0	0.9	0.1	-1.0	0.4
Arm fat mass (right)	0.3	1.4	3.2	-0.9	-0.6	1.6	1.8
Trunk predicted mass	0.3	1.9	6.7	1.4	-0.2	2.6	0.9
Birth weight of first child	0.3	0.5	1.9	0.2	1.4	0.2	-0.8
Leg fat percentage (right)	0.3	1.3	4.2	-2.1	0.0	0.6	1.3
Shortness of breath walking on level ground	0.3	0.3	1.2	-1.1	0.3	-0.4	-0.1
Neck or shoulder pain in last month	0.3	0.5	1.5	-0.9	-0.3	-0.1	-1.2
Angina (self-reported)	0.3	0.4	0.7	0.8	-0.2	0.7	0.8
Leg fat mass (right)	0.3	1.1	2.1	-1.4	-0.4	1.3	1.3
Arm predicted mass (right)	0.3	1.7	5.8	0.8	0.0	2.4	1.4
Alcohol intake frequency.	0.3	0.6	2.0	0.7	1.4	-0.5	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	0.3	-1.1	-0.5	-0.1
Whole body fat-free mass	0.3	1.8	6.5	1.1	-0.4	2.5	1.1
Leg fat-free mass (right)	0.3	1.5	5.3	0.4	-1.1	2.3	0.8
Arm fat percentage (left)	0.3	1.3	3.1	-1.5	-0.6	0.8	1.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	0.6	0.9	0.8	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	-1.1	0.9	-0.1	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.9	0.5	-1.0	-0.7	0.1
Whole body water mass	0.3	1.7	6.2	0.9	-0.4	2.5	1.1
Leg predicted mass (right)	0.3	1.3	4.8	0.3	-1.1	2.2	0.8
Arm fat mass (left)	0.3	1.4	2.5	-1.2	-0.8	1.6	1.6
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.4	-0.5	0.9	-0.7
Medication: Blood pressure	0.3	0.6	2.0	0.2	-1.4	0.6	0.8
Basal metabolic rate	0.3	1.5	5.4	0.7	-0.5	2.3	1.1
Number of operations (self-reported)	0.3	0.5	1.4	-0.1	-1.2	-0.9	-0.5
Unable to work because of sickness or disability	0.3	0.3	0.9	0.4	0.5	0.6	0.9
Commuting to job workplace: Cycle	0.3	0.3	1.2	-0.4	-0.4	-0.4	-1.1
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.4	0.1	0.7	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	-0.9	-0.2	-0.5	0.7
Blood White Count	0.2	1.2	5.0	-2.2	0.7	0.4	0.4
Allergy or Eczema	0.2	0.5	2.2	-0.0	0.6	-0.1	1.5
Lung FVC	0.2	0.8	1.7	-1.2	-1.3	-0.4	-0.8
Hair Pigment	0.2	4.9	11.3	0.3	3.4	1.5	3.3
Angina	0.2	0.3	0.7	0.7	0.0	0.6	0.9
Leg fat-free mass (left)	0.2	1.0	3.4	0.2	-0.9	1.8	0.9
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.4	-0.3	-0.8	-0.2
Supplements: Glucosamine	0.2	0.3	0.7	-0.8	-0.0	-0.3	-0.7
Leg predicted mass (left)	0.2	0.9	3.0	0.2	-0.8	1.7	1.0
Heart attack	0.2	0.2	0.6	-0.4	-0.4	-0.2	0.8
Medication: Simvastatin	0.2	0.3	0.8	-0.2	0.4	0.9	0.6
Weight	0.2	1.1	3.5	-0.2	-0.7	1.9	1.3
Lung cancer (father)	0.2	0.3	1.3	-0.1	0.1	-0.1	-1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.2	0.6	-0.8	-0.9
Body fat percentage	0.2	0.6	2.0	-0.8	-0.6	0.1	1.4
Arm fat-free mass (right)	0.2	1.3	4.6	0.6	-0.1	2.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.9	-0.2	-1.0	0.4	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.9	1.0	-0.3	-0.3	0.5
Heart disease (mother)	0.2	0.3	1.2	0.0	-1.1	0.1	0.4
Whole body fat mass	0.2	0.7	2.6	-0.4	-0.5	0.7	1.6
Had major operations	0.2	0.2	0.5	-0.1	0.7	-0.7	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.6	0.4	0.8	0.6
Medication for cholesterol	0.2	0.4	0.7	0.8	0.8	-0.4	-0.5
Medication: Gliclazide	0.2	0.3	0.7	-0.9	-0.2	0.6	0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	-0.6	-0.8	-0.1	0.3
Blood Platelet Count	0.1	1.0	4.4	-2.1	0.5	0.1	0.7
Hypothyroidism (self reported)	0.1	0.3	0.9	0.9	0.3	-0.3	0.4
Trunk fat percentage	0.1	0.5	1.5	0.1	-0.7	-0.7	1.2
Qualifications: CSEs or equivalent	0.1	0.1	0.3	0.5	-0.1	-0.4	0.4
Trunk fat mass	0.1	0.5	1.7	0.3	-0.7	0.2	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.1	-0.2	0.4	0.3	-0.3
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.6	-0.2	-0.6	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.7	-0.0	-0.3	0.5
Age at first live birth	0.1	0.2	0.4	0.4	0.2	-0.4	-0.6
Breast cancer (self-reported)	0.1	0.1	0.3	0.4	0.2	-0.5	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.5	0.6	-0.3	-0.3
High cholesterol (Self-reported)	0.1	0.1	0.3	-0.6	-0.3	0.2	0.3
Medication: Lisinopril	0.1	0.2	0.5	-0.5	-0.4	-0.7	-0.1
Irritability	0.1	0.1	0.3	-0.5	-0.1	0.3	0.6
Medication: Ibuprofen	0.0	0.1	0.1	-0.4	0.1	0.0	-0.4

Hub : Genes

DCP1A

Models

Trait associations