Hub : Genes

TKT

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0550 0.0220 6.4e-04 0.051 0.006 0.027 0.023 0.027 7.5e-07 5.7e-02 2.7e-04 7.1e-04 2.9e-04
2 GTEx Cells Transformed fibroblasts 0.1690 0.0570 1.5e-03 0.019 NA 0.013 NA 0.035 1.2e-02 NA 3.5e-02 NA 1.2e-03
3 GTEx Esophagus Mucosa 0.0700 0.0280 1.3e-03 0.017 NA 0.018 NA 0.018 2.3e-02 NA 2.1e-02 NA 2.3e-02
4 NTR Blood 0.0584 0.0163 2.5e-09 0.044 0.034 0.040 0.037 0.039 4.5e-14 3.4e-11 7.8e-13 4.0e-12 1.3e-12
5 YFS Blood 0.2775 0.0366 0.0e+00 0.254 0.263 0.294 0.276 0.291 2.3e-82 5.7e-86 1.5e-97 8.0e-91 1.3e-96
6 TCGA Brain Lower Grade Glioma 0.0624 0.0360 4.0e-06 0.048 0.048 0.041 NA 0.037 3.6e-06 3.4e-06 1.6e-05 NA 4.1e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 3.1 4.9 11.0 1.0 -1.3 2.8 -1.8 -2.2 3.3
Bipolar Disorder or Schizophrenia 4.4 10.7 22.3 2.6 0.1 4.7 -2.6 -2.8 4.6
Depressed Affect (Nagel 2018) 2.0 4.1 6.0 2.5 2.3 2.3 -1.9 -1.3 1.7
Depression (Nagel 2018) 2.8 4.3 6.1 2.4 2.5 1.9 -2.4 -2.0 0.8
Intelligence (Savage-Jansen 2018) 2.1 6.4 21.6 -3.0 -2.6 -4.7 0.1 -0.1 -0.8
Neuroticism (Nagel 2018) 4.6 10.9 19.0 4.4 3.6 3.9 -2.7 -1.9 2.7
Schizophrenia (2018) 3.2 6.6 14.8 2.5 1.2 3.8 -1.9 -1.9 3.2
Schizophrenia vs Biploar Disorder 0.5 0.7 1.4 1.0 0.8 1.0 -0.4 -0.2 1.2
Worry (Nagel 2018) 4.9 10.3 19.6 4.4 3.6 4.0 -2.4 -1.7 2.2
Alzheimer’s Disease (in mother) 0.3 0.3 1.3 0.4 0.1 0.1 -0.5 -0.1 1.2
Alzheimer’s Disease (in father) 1.3 1.4 3.8 2.0 1.7 -0.0 -0.5 0.3 -1.1
Alzheimer’s Disease (including proxy) 0.5 0.8 2.6 1.6 0.9 0.1 -0.9 -0.3 0.6
Crohns Disease (2017) 0.7 1.4 3.4 -1.1 -1.9 -0.6 1.4 1.2 -0.2
Irritable Bowel Disease (IBD) 0.7 1.8 3.2 -0.1 -1.4 1.3 1.8 1.8 0.8
Ulcerative Colitis (UC) 0.8 1.5 4.0 0.6 -0.7 2.0 1.1 1.3 1.3
Major Depression (MDD) 1.2 1.5 4.8 0.9 -0.2 2.2 0.1 -0.6 1.7
Reaction Time 1.2 2.2 4.0 -2.0 -2.0 -1.3 1.5 1.2 -0.2
Verbal and Numeric Reasoning (VNR) 3.3 7.9 27.5 -3.2 -2.5 -5.2 1.0 0.9 -1.2
Breast Cancer 1.3 3.1 8.0 -2.1 -2.8 -0.8 1.2 1.0 1.7
Ovarian Cancer 1.0 1.3 2.7 -1.2 -1.1 -0.9 1.7 0.7 -1.0
Prostate Cancer 0.5 0.7 1.5 -1.2 -0.9 -0.5 0.5 0.4 -1.2
Age at First Birth 1.6 2.4 7.6 -1.9 -1.5 -2.8 0.1 0.6 0.2
Bipolar Disorder (2011) 1.5 1.4 5.4 0.8 -1.1 1.1 -0.1 -0.4 2.3
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 0.4 0.2 -0.2 -0.4 -1.0 1.0
Coronary Artery Disease (CAD) 1.1 1.3 3.2 0.8 -0.1 1.8 -0.0 -0.8 1.8
Crohns Disease (2012) 0.5 0.9 2.6 -1.0 -1.6 -0.7 0.8 0.6 -0.2
Mean Putamen Volume 0.9 1.0 2.2 -0.4 -1.5 1.0 1.2 0.5 0.8
Fasting Glucose 0.9 1.1 1.8 1.3 0.7 1.3 0.5 1.1 1.2
HbA1C 0.6 0.6 1.3 0.7 0.5 0.2 1.1 1.0 -0.8
HDL Cholesterol 0.6 1.0 3.6 0.9 0.5 -1.9 -1.0 -0.5 -0.2
LDL Cholesterol 1.4 2.2 5.7 -1.9 -1.2 -2.4 0.4 -0.2 -1.4
Lupus 1.1 1.6 3.4 -0.6 -1.7 0.4 1.1 1.9 1.2
Neuroticism (2016) 1.3 1.8 4.2 1.0 0.7 1.5 -1.3 -1.1 2.1
Primary Biliary Cirrhosis 2.1 3.1 7.1 -1.6 -1.7 -2.7 1.3 0.5 -2.0
Rheumatoid Arthritis 0.5 0.7 1.8 -0.3 0.9 -1.3 -0.9 -0.1 -0.8
Schizophrenia (2014) 3.9 8.6 22.8 2.1 0.1 4.8 -1.8 -1.7 4.3
Triglycerides 0.2 0.3 1.0 -0.6 -0.2 -0.3 0.0 -0.7 -1.0
Type 2 Diabetes (T2D) (2012) 1.2 1.4 3.4 -0.7 -0.7 -0.2 1.4 1.8 -1.5
Ulcerative Colitis 1.1 1.6 4.3 0.6 -0.2 2.1 1.6 1.4 0.6
Blood Eosinophil Count 0.1 0.7 1.5 -0.1 -0.6 -1.2 0.7 0.7 1.1
Blood Platelet Count 0.0 0.1 0.3 0.0 -0.5 -0.3 -0.4 -0.1 0.2
Blood Red Count 0.7 6.9 29.4 1.8 0.2 5.4 2.0 2.0 0.7
Blood White Count 0.5 4.0 9.9 3.1 2.5 2.5 -0.8 -0.9 -0.2
Heel T-Score 0.8 6.4 18.0 2.9 4.2 2.3 -2.5 -0.8 0.1
BMI 0.5 3.1 6.3 -2.0 -2.2 -1.4 2.5 1.2 0.5
Height 0.2 3.9 15.1 1.4 1.7 -3.9 -0.6 0.1 -1.8
Waist Hip Ratio (WHR) 5.2 23.3 54.5 7.4 5.1 6.7 -3.3 -1.6 1.1
Systolic Blood Pressure 0.3 1.7 3.5 -1.7 -0.8 -1.3 1.9 -0.2 -1.3
Smoking Status 0.3 0.7 1.5 -0.5 0.7 -0.8 0.4 1.1 -1.2
Allergy or Eczema 0.6 1.5 3.3 1.8 1.1 1.5 -0.9 0.1 1.0
Cardiovascular Disease 0.1 0.5 1.1 -0.7 -0.1 -0.7 0.3 -0.7 -1.1
Hypothyroidism (self reported) 0.1 0.2 0.5 0.7 0.3 0.2 -0.2 -0.5 0.7
Respiratory disease 0.1 0.3 1.2 0.3 0.1 0.2 -0.2 0.4 1.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.6 1.1 1.2 0.2 0.0 -0.0 -0.3
Lung FEV1/FVC ratio 0.7 3.6 7.7 -2.0 -1.1 -2.8 0.9 -1.0 -2.6
Lung FVC 0.1 0.3 1.3 -1.1 -0.3 -0.6 -0.3 -0.1 -0.2
Neuroticism 3.1 7.5 12.6 3.4 2.0 3.4 -1.9 -1.3 3.6
Chronotype (morning person) 0.6 1.3 5.6 1.0 2.4 -0.2 -0.8 0.3 -0.9
Hair Pigment 0.2 5.1 9.4 -0.4 -1.8 2.2 2.1 3.1 3.0
Tanning 0.2 1.9 4.7 -2.1 -0.9 -2.2 0.2 -0.1 -1.1
Hand grip strength (left) 1.3 3.5 7.4 2.4 2.7 0.7 -2.3 -1.5 0.2
Number of treatments/medications taken 0.5 1.0 3.0 1.0 0.7 1.7 0.6 0.1 0.9
Average weekly spirits intake 1.4 1.7 3.6 -1.5 -0.0 -1.9 1.3 0.9 -1.4
Sensitivity / hurt feelings 3.8 6.5 13.5 3.5 2.0 3.7 -1.2 -0.2 2.9
Frequency of depressed mood in last 2 weeks 2.8 4.0 6.7 2.5 2.2 2.6 -1.8 -1.1 1.3
Hearing difficulty/problems: Yes 1.3 2.0 6.5 0.3 -0.0 0.1 2.3 2.5 -0.1
Relative age of first facial hair 0.5 1.0 2.1 0.2 -1.0 1.5 0.7 0.6 1.4
Other serious medical condition/disability diagnosed by doctor 1.8 2.3 6.9 1.2 0.1 2.6 -0.5 -0.3 2.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.5 -0.6 -0.4 0.4 1.2 1.2 -1.0
Ever had hysterectomy (womb removed) 0.8 0.9 2.3 -0.5 -1.0 0.7 1.2 1.5 -0.0
Systolic blood pressure, automated reading 1.6 4.5 11.4 -2.8 -2.1 -1.0 3.4 1.3 -1.1
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.1 -0.1 0.1 0.8 0.7 1.1 0.4
Angina 0.2 0.3 0.9 0.2 0.2 0.6 0.7 0.1 0.9
Medication for hormone replacement therapy 0.6 0.7 1.6 -0.9 -1.3 -0.0 0.7 1.0 0.3
Vitamin and mineral supplements 1.1 1.5 5.4 0.4 -0.6 2.3 1.1 0.9 1.0
Supplements: Zinc 0.7 0.7 1.6 1.1 1.3 0.3 -1.0 0.3 -0.5
Medication: Co-codamol 1.4 1.6 4.2 1.4 2.0 0.6 -1.5 -0.9 -0.2
Medication: Metformin 0.5 0.7 1.6 1.1 0.5 1.2 0.7 0.8 0.5
Diabetes (father) 0.3 0.4 1.9 -0.2 0.1 -0.3 0.6 0.2 -1.4
Diabetes (mother) 2.9 3.7 7.7 2.8 2.1 2.4 -0.8 -0.4 1.9
Severe depression (siblings) 1.0 1.1 2.9 0.4 0.5 0.4 -1.7 -1.6 0.8
Pack years adult smoking proportion 1.4 2.1 8.0 1.3 0.6 2.8 1.3 1.0 -0.1
Impedance of leg (right) 1.5 7.2 18.7 4.3 3.5 1.2 -2.7 -1.9 -0.5
Leg fat-free mass (left) 0.5 2.8 6.0 -2.5 -2.0 -1.5 1.6 1.2 0.4
Trunk fat percentage 0.2 0.7 1.3 0.1 -1.2 0.7 1.0 -0.2 1.1
Hand grip strength (right) 1.3 3.6 8.1 1.9 2.8 -1.2 -2.4 -1.5 -0.6
Townsend deprivation index at recruitment 0.2 0.3 1.4 -0.0 0.4 0.2 -0.3 -0.4 -1.2
Current tobacco smoking 0.1 0.2 0.3 0.2 0.3 -0.3 -0.4 -0.5 -0.5
Average weekly fortified wine intake 0.1 0.1 0.3 0.2 0.1 -0.4 0.2 0.6 0.5
Maternal smoking around birth 1.8 2.5 6.4 0.7 0.5 2.5 1.6 2.2 0.7
Fed-up feelings 2.1 3.9 7.1 2.4 2.1 2.7 -1.6 -0.8 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.5 3.9 1.8 2.0 1.6 -1.7 -1.2 0.7
Relative age voice broke 0.7 1.0 2.5 -1.2 -1.3 -1.6 -0.2 -0.7 0.4
Taking other prescription medications 1.5 2.3 5.5 2.4 1.8 1.5 -0.7 -0.7 1.3
Age when periods started (menarche) 0.8 1.9 5.9 -0.1 1.3 -2.4 -1.6 -0.7 -0.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.4 0.8 1.2 0.3 -0.6 -0.4 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 3.6 1.5 1.9 1.4 0.3 1.3 0.4
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.8 -0.3 -0.6 0.0 1.1 1.1 -1.4
Qualifications: CSEs or equivalent 1.9 2.5 5.8 2.2 2.4 1.5 -1.1 -0.9 0.3
Serious illness, injury or assault to yourself 1.1 1.3 2.1 1.2 1.5 1.4 -1.1 0.0 1.0
High blood pressure 0.1 0.2 1.0 -0.2 -0.1 0.2 -0.1 -1.0 -0.2
Hayfever, allergic rhinitis or eczema 0.9 1.9 5.6 1.3 0.2 2.4 -0.4 0.4 1.9
Multivitamins +/- minerals 1.5 1.9 5.1 -0.1 1.2 -2.3 -0.9 -0.8 -1.8
Stomach or abdominal pain in last month 2.5 3.1 7.6 2.0 1.3 2.8 -1.1 -1.1 1.7
Supplements: Glucosamine 0.2 0.3 0.9 0.3 0.9 -0.2 0.3 0.4 -0.6
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 4.3 1.4 1.7 0.2 -2.1 -1.5 0.6
Medication: Atenolol 0.9 1.1 2.8 1.1 0.7 0.7 -1.1 -1.7 0.4
Medication: Levothyroxine sodium 0.4 0.6 3.0 0.0 -0.5 -0.2 -0.1 -0.7 1.7
Sitting height 0.4 2.9 5.7 -2.3 -1.8 -2.4 1.1 1.4 -0.5
Chronic bronchitis/emphysema (father) 1.0 1.1 1.7 1.1 1.3 1.2 -1.0 -0.3 1.2
High blood pressure (mother) 1.8 2.6 8.8 1.8 0.9 3.0 -0.1 0.3 1.5
Body mass index (BMI) 0.6 2.6 5.2 -1.8 -1.9 1.0 2.3 1.2 1.1
Impedance of leg (left) 1.0 4.9 14.1 3.8 2.8 1.1 -1.8 -1.1 -1.1
Leg predicted mass (left) 0.5 2.7 5.9 -2.4 -2.0 -1.5 1.5 1.1 0.5
Trunk fat mass 0.2 0.8 1.7 -0.4 -1.3 0.1 1.2 0.4 1.0
Waist circumference 0.5 1.8 7.3 1.1 0.0 2.7 0.6 0.2 1.5
Number of incorrect matches in round 0.7 1.1 4.3 1.2 0.5 2.1 -0.0 -0.1 0.8
Past tobacco smoking 0.3 0.6 2.5 0.4 -0.5 -0.0 -0.8 -1.6 0.4
Alcohol usually taken with meals 0.8 1.3 2.1 0.8 1.3 -0.8 -1.4 -1.4 -0.9
Nervous feelings 2.0 3.8 9.6 2.6 1.6 3.1 -0.9 -0.8 1.6
Frequency of tenseness / restlessness in last 2 weeks 3.9 6.1 17.4 2.3 1.3 4.2 -1.5 -0.8 3.1
Hearing difficulty/problems with background noise 0.8 1.3 3.9 1.1 0.5 1.3 0.8 2.0 0.6
Hair/balding pattern: Pattern 2 0.2 0.2 0.7 -0.9 -0.4 -0.3 0.2 0.4 -0.3
Had menopause 2.1 2.6 4.5 -1.8 -1.4 -0.9 2.1 1.8 -1.3
Had other major operations 0.2 0.3 1.3 -0.1 -0.5 -1.2 0.2 -0.2 0.2
Forced vital capacity (FVC) 0.2 0.6 1.6 0.8 1.2 -0.2 -1.0 0.3 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.4 6.7 2.2 2.6 1.3 0.0 1.1 0.2
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 3.5 1.1 -0.2 1.3 -1.9 -1.9 1.7
Qualifications: None of the above 0.6 1.2 5.6 0.6 2.4 0.1 -0.1 0.3 -1.0
Financial difficulties in last 2 years 1.1 1.5 4.0 -0.2 -0.9 2.0 1.0 1.2 1.2
Mouth/teeth dental problems 1.1 1.8 2.9 0.3 1.6 -0.7 -1.6 -1.7 -1.3
Heart attack 2.2 2.8 6.0 2.2 1.4 1.1 -1.5 -2.4 0.8
Allergy 1.5 3.4 8.0 -1.8 -0.5 -2.8 1.0 0.3 -2.8
Pain all over the body in last month 0.3 0.3 0.9 0.3 0.2 0.6 -0.5 -0.4 1.0
Diabetes (self-reported) 0.5 0.7 2.2 1.5 1.1 0.8 -0.1 -0.1 0.3
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 0.6 0.6 0.8 0.1 0.5 0.1
Medication: Ramipril 1.4 1.8 6.0 0.9 1.0 0.1 -1.6 -2.5 -0.7
Medication: Simvastatin 1.4 2.1 4.0 2.0 2.0 1.5 -1.2 -1.0 0.2
Fluid intelligence score 2.9 6.0 20.2 -2.7 -2.7 -4.5 0.8 0.7 -0.8
Illnesses of siblings 0.3 0.4 0.8 -0.5 -0.9 -0.5 -0.7 0.5 0.9
Neuroticism score 3.2 6.6 13.4 3.1 1.7 3.7 -1.6 -0.8 3.3
Weight 0.3 1.6 3.2 -1.4 -1.4 -0.5 1.8 1.4 0.6
Impedance of arm (right) 0.6 2.7 5.8 2.4 1.1 -0.9 -1.6 -1.9 -1.4
Arm fat percentage (right) 0.4 1.5 3.3 -0.8 -1.8 0.8 1.8 0.3 1.0
Trunk fat-free mass 0.2 1.3 2.8 -1.7 -0.9 -1.4 0.9 1.2 0.4
Hip circumference 0.9 3.9 8.9 -3.0 -2.7 -1.2 2.2 0.9 0.4
Time employed in main current job 1.7 2.0 5.5 1.8 2.3 1.7 -0.4 0.3 0.2
Alcohol intake versus 10 years previously 0.1 0.2 0.4 0.4 0.3 -0.0 -0.6 -0.5 0.2
Father’s age at death 1.9 2.6 6.1 -1.5 -2.5 -1.4 1.6 1.5 -0.6
Worrier / anxious feelings 5.4 10.2 16.1 4.0 2.8 3.6 -3.0 -2.2 3.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 3.7 0.4 0.0 1.0 -0.6 -0.3 1.9
Falls in the last year 1.8 2.5 8.6 1.0 -0.0 2.3 -0.3 0.2 2.9
Hair/balding pattern: Pattern 3 0.8 1.2 2.6 1.1 1.2 -0.7 -1.3 -1.6 0.4
Number of live births 2.8 4.0 5.5 1.9 1.7 1.6 -2.0 -2.2 2.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.0 0.3 0.8 -0.9 -1.0 -0.5 -0.9
Pulse rate 11.0 18.5 27.8 3.9 2.9 5.3 -4.7 -4.3 4.4
Happiness 1.6 2.0 4.6 1.4 0.7 0.3 -1.9 -2.1 1.0
Noisy workplace 0.8 0.9 1.9 0.8 1.4 -0.5 -0.9 -1.0 -1.0
Qualifications: A levels/AS levels or equivalent 1.4 3.0 5.5 -1.8 -2.3 -1.9 -1.0 -2.0 1.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.4 0.6 -0.2 1.5 -1.1 -1.5 1.6
Mouth/teeth dental problems: Dentures 0.2 0.4 1.1 0.6 -0.4 0.5 0.6 0.6 1.1
Asthma 0.4 0.8 1.7 0.9 1.3 0.1 -1.2 -0.7 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.1 -0.5 -1.1 -1.4 1.0 0.7 -0.5
Medication: Cholesterol lowering 0.6 1.0 2.5 1.0 0.8 0.0 -1.2 -1.6 0.7
Depression (self-reported) 2.7 3.2 7.8 1.6 0.6 2.8 -1.4 -1.4 2.1
Medication: Lansoprazole 1.0 1.1 2.1 1.2 1.4 0.5 -1.2 -1.2 0.4
Prospective memory result 0.3 0.3 0.9 0.6 0.4 0.1 -0.6 -0.9 0.5
Lung cancer (father) 0.8 1.0 3.0 0.4 0.9 -0.1 0.7 1.7 -1.1
Illnesses of mother 1.3 1.6 3.1 -1.1 -0.8 -1.8 -1.0 -1.4 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 1.1 0.4 0.6 -0.2 -1.1 -0.5 -0.5
Pulse wave Arterial Stiffness index 1.2 1.4 2.8 -1.6 -1.2 -0.6 1.7 0.9 -0.4
Impedance of arm (left) 0.5 2.4 5.5 2.3 0.8 -0.9 -1.5 -1.9 -1.2
Arm fat mass (right) 0.5 1.9 4.1 -1.4 -2.0 0.4 1.9 0.8 1.0
Trunk predicted mass 0.3 1.5 3.0 -1.7 -1.0 -1.4 1.0 1.3 0.3
Standing height 0.2 2.1 10.1 0.7 0.7 -3.2 -0.9 0.2 -0.8
Length of working week for main job 1.2 1.4 3.4 -0.2 -0.5 1.2 1.7 1.9 -0.4
Exposure to tobacco smoke at home 1.6 1.8 3.9 1.0 0.1 1.7 -1.1 -1.2 2.0
Breastfed as a baby 0.7 0.9 2.6 -0.1 0.7 -1.6 -1.1 -0.7 -0.6
Tense / ‘highly strung’ 0.5 0.8 1.7 1.2 1.3 1.2 -0.0 0.1 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 4.4 6.7 15.9 3.3 2.3 4.0 -1.7 -0.6 2.1
Hair/balding pattern: Pattern 4 1.0 2.4 9.6 -1.1 -0.5 -3.1 0.5 0.1 -1.8
Birth weight of first child 0.3 0.5 2.3 0.1 -0.2 -1.5 -0.3 0.1 -0.5
Peak expiratory flow (PEF) 0.7 1.7 4.6 -0.4 1.0 -2.1 -0.1 0.3 -2.1
Pulse wave reflection index 1.4 1.7 3.6 -1.1 -0.5 -1.4 1.9 1.6 -0.7
Ever highly irritable/argumentative for 2 days 0.6 0.8 2.6 -0.0 0.2 -1.6 -0.9 -1.0 -0.0
Loud music exposure frequency 0.9 1.0 2.5 -0.2 -1.4 0.4 1.6 1.0 0.3
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 2.1 -0.0 -0.7 -1.4 -0.9 -0.9 0.4
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 3.8 -1.3 -2.0 1.0 1.8 1.4 0.6
Blood clot in the leg (DVT) 1.5 1.9 3.2 1.4 1.8 0.6 -1.5 -1.4 1.3
Medication: Paracetamol 0.4 0.6 1.5 0.5 -0.2 1.2 -0.6 -0.7 1.0
Headache pain in last month 3.5 6.0 11.3 3.1 2.1 3.4 -1.3 -1.0 2.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.2 -1.0 -0.9 -0.6 0.7 1.1 -0.6
Glaucoma (self-reported) 1.4 1.6 6.7 0.9 0.7 2.6 0.6 1.2 0.3
Gout (self-reported) 3.3 4.6 17.0 1.6 0.6 4.1 0.1 1.0 2.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.7 -0.2 -0.5 -0.5 0.6 0.2 0.8
Medication: Amlodipine 1.4 1.9 6.1 -0.2 -0.9 2.1 0.5 0.2 2.5
Medication: Ventolin 100micrograms inhaler 0.8 1.1 1.6 0.8 1.3 1.2 -1.1 -0.9 0.8
Birth weight 0.3 0.6 1.4 -0.7 -0.7 -1.2 -0.6 -0.9 0.2
Chronic bronchitis/emphysema (mother) 1.2 1.4 5.1 0.9 2.3 -1.2 -0.7 0.0 -0.7
High blood pressure (siblings) 0.9 1.3 2.8 -1.5 -1.5 -0.3 1.7 0.4 -0.7
Forced vital capacity (FVC), Best measure 0.1 0.4 0.9 0.9 0.7 0.6 -0.9 0.1 0.3
Body fat percentage 0.2 0.8 1.8 -0.1 -1.1 0.8 1.3 0.2 1.1
Leg fat percentage (right) 0.2 0.5 1.4 0.1 -0.3 1.0 1.2 0.3 0.9
Arm fat-free mass (right) 0.2 0.9 1.8 -1.4 -0.7 -0.5 0.8 1.3 0.8
Exposure to tobacco smoke outside home 0.5 0.6 1.8 0.9 0.3 1.4 -0.4 -0.4 0.8
Comparative body size at age 10 0.5 1.5 3.6 -1.5 -1.9 -1.4 -0.2 -1.1 -0.2
Number of full brothers 0.2 0.3 1.4 -0.2 -0.5 0.4 0.2 -0.1 1.2
Worry too long after embarrassment 1.8 3.1 9.1 1.3 0.2 2.7 -0.2 0.4 3.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.8 2.2 1.2 0.9 1.5 -0.7 0.0 0.5
Wheeze or whistling in the chest in last year 1.6 2.8 5.6 2.2 1.9 2.4 -0.3 0.3 1.6
Number of children fathered 1.1 1.2 3.5 -0.7 0.7 -1.9 0.6 0.8 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.9 0.8 0.5 -0.0 -0.2 0.0 -1.0
Age at first live birth 1.1 1.9 4.6 -1.3 -1.6 -2.2 0.9 0.9 -0.9
Pulse wave peak to peak time 0.8 1.0 2.1 1.4 1.0 0.3 -1.4 -0.6 0.3
Health satisfaction 0.8 1.0 2.2 1.5 1.3 0.9 -0.8 -1.0 -0.3
Shortness of breath walking on level ground 0.9 1.0 2.5 0.9 1.6 0.9 -1.0 -1.0 0.1
Qualifications: College or University degree 1.8 5.8 20.7 -0.0 -3.1 1.4 -0.8 -1.1 4.5
Eye problems/disorders: None of the above 2.6 3.0 7.4 -0.8 0.7 -2.7 -1.2 -1.2 -2.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.9 0.4 -0.0 0.5 -0.8 -1.4 0.6
Emphysema/chronic bronchitis 0.4 0.4 2.1 0.1 -0.1 -0.2 -0.3 -0.4 1.4
Medication for pain relief, constipation, heartburn 0.3 0.5 1.8 -0.8 -0.5 -1.3 -0.2 0.5 -0.6
Neck or shoulder pain in last month 1.3 1.9 5.3 -1.0 -0.2 -1.0 1.6 2.3 -1.1
Medication: Blood pressure 0.3 0.5 1.0 1.0 0.6 0.9 0.0 -0.8 0.5
Angina (self-reported) 0.2 0.3 0.7 0.3 0.3 0.7 0.7 0.1 0.8
Migraine (self-reported) 0.8 1.0 2.9 -0.9 -1.7 0.2 0.3 0.3 1.5
Medication: Ibuprofen 1.4 1.7 4.0 -1.2 -1.5 -2.0 1.3 0.9 -0.3
Medication: Allopurinol 3.0 4.0 11.7 2.2 2.1 3.4 -0.4 0.7 1.6
Medication: Omeprazole 1.4 1.6 5.7 0.1 -0.5 1.5 -0.8 -0.9 2.4
Medication: Seretide 50 evohaler 0.9 1.1 2.7 1.2 1.1 1.7 -0.5 -0.1 0.9
Mean time to correctly identify matches 2.5 4.7 7.7 -2.8 -2.4 -2.4 2.3 1.8 -0.7
Heart disease (mother) 0.4 0.5 1.4 -0.0 0.0 -0.1 0.7 1.1 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.9 0.1 0.8 -0.7 -0.2 -0.6 -0.9
Whole body fat mass 0.3 1.3 2.6 -0.8 -1.6 0.3 1.6 0.8 1.1
Leg fat mass (right) 0.4 1.5 3.7 -1.2 -1.5 0.1 1.9 1.1 0.6
Arm predicted mass (right) 0.2 1.2 2.6 -1.6 -0.9 -0.6 1.0 1.3 0.8
Pulse rate, automated reading 9.8 31.7 45.2 5.2 2.7 6.4 -6.1 -5.8 6.7
Alcohol intake frequency. 1.0 2.2 4.9 2.2 1.6 1.5 -1.0 -1.6 -0.0
Comparative height size at age 10 0.2 1.2 6.2 -0.2 0.3 -2.5 -0.8 0.3 -0.2
Number of full sisters 1.0 1.3 3.3 1.8 1.3 1.4 -0.3 -0.2 0.7
Suffer from ‘nerves’ 1.9 2.9 6.1 2.5 2.0 2.4 -0.9 -0.6 0.7
Overall health rating 2.4 5.2 11.8 3.4 3.0 1.9 -1.8 -1.6 0.6
Chest pain or discomfort 1.2 1.7 5.9 1.5 0.9 2.4 -0.2 0.2 1.1
Had major operations 1.0 1.1 3.7 0.7 0.2 0.3 -1.3 -1.9 0.9
Age at last live birth 0.5 0.8 1.7 -0.6 -0.9 -0.9 0.8 1.3 -0.7
Family relationship satisfaction 1.9 2.4 4.5 2.1 1.3 1.7 -1.4 -1.1 1.4
Leg pain on walking 2.1 2.6 6.7 1.9 1.4 2.6 -0.3 -0.4 1.7
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 3.4 -0.4 -1.2 1.5 1.8 1.3 -0.1
Commuting to job workplace: Car/motor vehicle 1.3 1.5 6.0 0.7 0.2 0.5 -1.2 -0.7 2.4
Illness, injury, bereavement, stress in last 2 years 2.0 2.4 9.2 -0.9 -0.1 -3.0 0.6 0.0 -2.0
Medication: Aspirin 0.4 0.5 2.6 0.2 0.1 1.6 0.4 -0.3 0.4
Supplements: Vitamin C 0.8 1.0 2.0 0.2 0.9 -1.4 -1.1 -1.1 -0.8
Knee pain experienced in last month 0.7 1.0 3.7 -0.8 0.6 -0.7 0.9 0.3 -1.9
Hypertension (Self-reported) 0.1 0.3 1.1 -0.5 -0.3 -0.1 -0.0 -1.1 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 0.3 0.1 -0.7 -0.4 -0.5 0.1
Illnesses of father: Heart disease 0.6 0.9 2.9 -1.7 -1.2 0.4 0.4 -0.6 0.3
Illnesses of siblings: Diabetes 3.3 4.1 9.6 1.7 3.1 -0.7 -1.9 -2.4 -1.5
Smoking status: Previous 0.9 1.3 5.2 -0.3 0.6 0.2 1.3 2.3 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.4 0.2 0.1 0.2 -0.6 0.4 0.5
Whole body fat-free mass 0.3 1.8 4.0 -2.0 -1.4 -1.2 1.3 1.4 0.5
Leg fat-free mass (right) 0.6 3.2 7.0 -2.6 -2.2 -1.5 1.8 1.4 0.2
Arm fat percentage (left) 0.4 1.5 3.5 -0.8 -1.9 0.9 1.7 0.2 1.1
Average weekly red wine intake 0.6 0.9 2.9 -1.7 -0.6 -0.5 0.8 1.0 -0.3
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 0.5 0.6 0.3 -0.7 -1.0 -0.4
Mood swings 2.3 4.2 9.4 2.7 2.5 3.1 -1.0 -0.1 1.1
Loneliness, isolation 1.6 2.2 5.0 1.6 1.0 1.9 -1.1 0.1 2.2
Long-standing illness, disability or infirmity 0.4 0.7 1.4 0.1 -0.4 1.1 1.1 0.3 1.2
Ever had bowel cancer screening 0.4 0.5 1.8 0.8 1.3 -0.1 -0.4 0.4 -0.6
Diabetes diagnosed by doctor 0.2 0.3 0.6 0.8 0.6 0.0 0.7 0.5 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.9 0.7 1.0 0.1 0.6 0.4 -0.9
Friendships satisfaction 1.3 1.6 2.3 1.3 1.5 -0.7 -1.3 -1.5 -1.0
Qualifications: nursing, teaching 1.1 1.7 3.9 0.6 -0.5 -1.3 -1.7 -2.0 1.2
Commuting to job workplace: Walk 0.9 0.9 2.5 -1.6 -1.3 0.5 0.3 -0.3 -1.1
Eye problems/disorders: Cataract 1.9 2.2 5.7 1.2 -0.4 2.4 0.3 -0.3 2.4
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.0 -0.7 -1.0 -0.7 0.9 0.8 0.3
Medication for cholesterol 0.6 0.9 3.2 1.2 1.8 0.1 -0.2 0.8 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.6 1.1 0.9 1.2 0.3 0.2 0.0
Back pain experienced in last month 0.8 1.2 4.6 -0.6 0.6 -2.1 0.4 0.2 -1.4
Mineral and other dietary supplements 1.3 1.7 4.2 1.2 0.1 1.9 -1.0 -0.2 2.1
Breast cancer (self-reported) 0.1 0.2 0.4 -0.1 -0.4 -0.7 -0.2 0.5 0.1
Asthma (self-reported) 0.2 0.4 0.9 0.7 1.0 0.2 -0.8 -0.4 0.6
Osteoporosis (self-reported) 0.6 0.8 3.3 0.4 -0.4 0.4 -0.6 -1.8 0.8
Osteoarthritis (self-reported) 0.4 0.5 0.9 -0.9 -0.0 -0.9 -0.3 -0.8 -0.7
Medication: Aspirin 0.4 0.5 2.0 -0.3 -0.3 1.4 0.7 -0.3 -0.0
Medication: Gliclazide 0.1 0.1 0.2 0.5 0.3 0.1 0.3 0.0 -0.1
Illnesses of father: None of the above (group 1) 2.6 3.2 7.5 2.6 2.7 -0.4 -1.9 -0.6 -0.4
Smoking status: Current 0.2 0.3 0.6 0.1 0.5 -0.4 -0.7 -0.8 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 2.7 1.1 1.6 0.3 -1.6 -1.2 0.2
Whole body water mass 0.3 1.6 3.7 -1.9 -1.3 -1.2 1.2 1.2 0.5
Leg predicted mass (right) 0.6 3.0 6.7 -2.6 -2.1 -1.4 1.7 1.3 0.2
Arm fat mass (left) 0.4 1.8 3.8 -1.4 -1.9 0.2 1.9 0.9 0.8
Number of self-reported non-cancer illnesses 0.3 0.4 1.2 0.7 0.5 0.7 -0.3 -0.3 1.1
Average weekly champagne plus white wine intake 1.0 1.3 2.9 -1.4 -1.5 -1.7 0.5 0.4 -0.4
Miserableness 1.7 2.9 4.9 1.2 0.8 2.2 -2.2 -1.2 2.0
Guilty feelings 2.2 3.3 10.4 1.4 0.4 2.1 -1.4 -1.1 3.2
Wears glasses or contact lenses 1.9 2.2 10.6 -0.5 -0.7 -3.3 -0.5 -1.2 -0.2
Ever taken oral contraceptive pill 0.6 0.7 3.0 0.5 -0.6 0.6 -0.5 -0.1 1.7
Hearing aid user 1.8 2.0 5.0 -1.5 -0.5 -2.2 0.7 0.7 -1.8
Mother’s age at death 3.5 4.3 8.4 -2.0 -2.5 -2.9 1.9 1.6 -1.2
Financial situation satisfaction 0.6 0.7 2.1 1.1 0.9 1.4 -0.1 -0.0 0.4
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 0.8 0.4 0.7 0.3 0.4 -0.5
Commuting to job workplace: Public transport 0.5 0.6 2.4 -0.5 0.3 -1.6 -0.0 -0.1 -0.9
Eye problems/disorders: Glaucoma 2.9 3.4 11.2 0.9 -0.2 3.4 1.5 1.9 1.6
Medication: Blood pressure 0.6 1.2 4.3 -0.6 -0.9 0.4 -1.2 -2.1 0.5
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.5 0.0 0.0 1.2 1.0 1.0 0.4
Supplements: Fish oil (including cod liver oil) 0.8 1.1 4.0 -0.8 0.2 -1.0 1.0 0.2 -2.0
High cholesterol (Self-reported) 0.1 0.2 0.6 0.6 0.8 0.2 0.1 0.5 0.1
Medication: Bendroflumethiazide 0.3 0.5 0.9 -0.9 -0.6 -0.7 0.4 -0.1 -1.0
Medication: Paracetamol 0.6 0.9 3.1 0.3 -0.5 1.4 -0.1 -0.1 1.7
Medication: Lisinopril 0.6 0.8 1.5 1.0 1.2 0.8 -1.1 -0.8 0.0
Medication: Atorvastatin 0.1 0.1 0.3 -0.0 -0.4 0.4 0.3 -0.5 0.2
Illnesses of father: High blood pressure 1.4 1.7 4.8 -1.6 -2.2 1.2 0.9 0.3 0.8
Alcohol drinker status: Never 1.9 2.3 5.3 1.3 0.6 2.3 -0.4 -1.8 1.7
Ever smoked 0.1 0.1 0.5 -0.4 0.1 -0.1 0.0 0.7 -0.3
Basal metabolic rate 0.3 1.8 3.6 -1.9 -1.4 -1.1 1.4 1.3 0.5
Leg fat percentage (left) 0.3 0.9 3.2 -0.2 -0.6 0.9 1.8 0.9 0.3
Arm fat-free mass (left) 0.3 1.6 3.0 -1.7 -1.0 -0.4 1.5 1.7 0.6
Number of operations (self-reported) 0.4 0.6 1.3 0.8 0.9 -0.7 -0.6 -1.2 -0.1
Average weekly beer plus cider intake 1.8 2.6 7.7 1.5 0.6 2.8 -0.1 -0.2 2.3
Irritability 0.2 0.4 1.7 0.0 -0.3 1.3 0.4 0.1 0.6
Risk taking 2.1 3.1 11.0 2.0 1.6 3.3 -0.6 0.1 0.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 2.8 -0.6 -0.2 -1.7 0.8 0.2 -1.2
Fractured/broken bones in last 5 years 3.0 3.8 8.3 -2.6 -2.9 -0.9 2.2 1.5 0.1
Age started oral contraceptive pill 0.8 1.0 1.8 -0.8 -0.9 -1.2 -1.0 -1.3 0.5
Diastolic blood pressure, automated reading 1.2 3.7 16.5 1.2 0.6 4.1 0.9 0.1 1.8
Ever depressed for a whole week 1.0 1.2 2.2 1.1 -0.0 0.5 -1.2 -1.5 1.5
Unable to work because of sickness or disability 0.9 1.1 3.8 0.8 0.8 1.9 -0.5 -0.5 1.0
Commuting to job workplace: Cycle 0.2 0.3 0.6 -0.2 0.6 -0.8 -0.7 -0.2 -0.5
Myopia 2.3 3.4 8.7 -0.3 -0.7 -2.0 -2.6 -3.0 -0.1
Vascular/heart problems diagnosed by doctor 0.3 0.8 2.9 -0.5 -0.5 -0.9 0.6 1.7 -0.5
Cholesterol lowering medication 0.4 0.6 1.6 1.1 0.6 1.3 0.7 0.1 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 4.0 -0.0 -0.6 1.0 -0.7 -1.0 2.0
Pain experienced in last month 0.5 0.9 1.8 -0.1 -0.7 0.7 -1.2 -1.1 1.3
Supplements: Calcium 0.9 1.0 2.8 -0.2 0.1 -1.0 -1.4 -1.7 -0.5
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 -0.2 -0.1 -0.1 0.2 0.1 -0.6
Heart attack/myocardial infarction (self-reported) 1.6 2.0 4.8 1.9 1.2 0.8 -1.2 -2.2 0.3
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 3.0 1.3 1.7 0.4 -1.5 -1.5 0.9
Heart disease (siblings) 0.9 1.1 3.8 1.1 0.7 1.9 0.4 -0.1 1.1
Alcohol drinker status: Previous 0.2 0.2 0.6 0.2 -0.4 0.3 -0.2 -0.5 0.8
Pack years of smoking 1.1 1.6 5.2 1.1 0.4 2.3 1.4 0.9 -0.2
Impedance of whole body 0.8 4.1 11.6 3.4 2.1 0.3 -2.0 -1.8 -1.1
Leg fat mass (left) 0.5 2.1 5.2 -1.4 -1.7 0.1 2.3 1.4 0.4
Arm predicted mass (left) 0.3 1.3 2.8 -1.5 -0.7 -0.5 1.3 1.7 0.7