Hub : Genes

TKT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0550	0.0220	6.4e-04	0.051	0.006	0.027	0.023	0.027	7.5e-07	5.7e-02	2.7e-04	7.1e-04	2.9e-04
2	GTEx	Cells Transformed fibroblasts	0.1690	0.0570	1.5e-03	0.019	NA	0.013	NA	0.035	1.2e-02	NA	3.5e-02	NA	1.2e-03
3	GTEx	Esophagus Mucosa	0.0700	0.0280	1.3e-03	0.017	NA	0.018	NA	0.018	2.3e-02	NA	2.1e-02	NA	2.3e-02
4	NTR	Blood	0.0584	0.0163	2.5e-09	0.044	0.034	0.040	0.037	0.039	4.5e-14	3.4e-11	7.8e-13	4.0e-12	1.3e-12
5	YFS	Blood	0.2775	0.0366	0.0e+00	0.254	0.263	0.294	0.276	0.291	2.3e-82	5.7e-86	1.5e-97	8.0e-91	1.3e-96
6	TCGA	Brain Lower Grade Glioma	0.0624	0.0360	4.0e-06	0.048	0.048	0.041	NA	0.037	3.6e-06	3.4e-06	1.6e-05	NA	4.1e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	3.1	4.9	11.0	1.0	-1.3	2.8	-1.8	-2.2	3.3
Bipolar Disorder or Schizophrenia	4.4	10.7	22.3	2.6	0.1	4.7	-2.6	-2.8	4.6
Depressed Affect (Nagel 2018)	2.0	4.1	6.0	2.5	2.3	2.3	-1.9	-1.3	1.7
Depression (Nagel 2018)	2.8	4.3	6.1	2.4	2.5	1.9	-2.4	-2.0	0.8
Intelligence (Savage-Jansen 2018)	2.1	6.4	21.6	-3.0	-2.6	-4.7	0.1	-0.1	-0.8
Neuroticism (Nagel 2018)	4.6	10.9	19.0	4.4	3.6	3.9	-2.7	-1.9	2.7
Schizophrenia (2018)	3.2	6.6	14.8	2.5	1.2	3.8	-1.9	-1.9	3.2
Schizophrenia vs Biploar Disorder	0.5	0.7	1.4	1.0	0.8	1.0	-0.4	-0.2	1.2
Worry (Nagel 2018)	4.9	10.3	19.6	4.4	3.6	4.0	-2.4	-1.7	2.2
Alzheimer’s Disease (in mother)	0.3	0.3	1.3	0.4	0.1	0.1	-0.5	-0.1	1.2
Alzheimer’s Disease (in father)	1.3	1.4	3.8	2.0	1.7	-0.0	-0.5	0.3	-1.1
Alzheimer’s Disease (including proxy)	0.5	0.8	2.6	1.6	0.9	0.1	-0.9	-0.3	0.6
Crohns Disease (2017)	0.7	1.4	3.4	-1.1	-1.9	-0.6	1.4	1.2	-0.2
Irritable Bowel Disease (IBD)	0.7	1.8	3.2	-0.1	-1.4	1.3	1.8	1.8	0.8
Ulcerative Colitis (UC)	0.8	1.5	4.0	0.6	-0.7	2.0	1.1	1.3	1.3
Major Depression (MDD)	1.2	1.5	4.8	0.9	-0.2	2.2	0.1	-0.6	1.7
Reaction Time	1.2	2.2	4.0	-2.0	-2.0	-1.3	1.5	1.2	-0.2
Verbal and Numeric Reasoning (VNR)	3.3	7.9	27.5	-3.2	-2.5	-5.2	1.0	0.9	-1.2
Breast Cancer	1.3	3.1	8.0	-2.1	-2.8	-0.8	1.2	1.0	1.7
Ovarian Cancer	1.0	1.3	2.7	-1.2	-1.1	-0.9	1.7	0.7	-1.0
Prostate Cancer	0.5	0.7	1.5	-1.2	-0.9	-0.5	0.5	0.4	-1.2
Age at First Birth	1.6	2.4	7.6	-1.9	-1.5	-2.8	0.1	0.6	0.2
Bipolar Disorder (2011)	1.5	1.4	5.4	0.8	-1.1	1.1	-0.1	-0.4	2.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	0.4	0.2	-0.2	-0.4	-1.0	1.0
Coronary Artery Disease (CAD)	1.1	1.3	3.2	0.8	-0.1	1.8	-0.0	-0.8	1.8
Crohns Disease (2012)	0.5	0.9	2.6	-1.0	-1.6	-0.7	0.8	0.6	-0.2
Mean Putamen Volume	0.9	1.0	2.2	-0.4	-1.5	1.0	1.2	0.5	0.8
Fasting Glucose	0.9	1.1	1.8	1.3	0.7	1.3	0.5	1.1	1.2
HbA1C	0.6	0.6	1.3	0.7	0.5	0.2	1.1	1.0	-0.8
HDL Cholesterol	0.6	1.0	3.6	0.9	0.5	-1.9	-1.0	-0.5	-0.2
LDL Cholesterol	1.4	2.2	5.7	-1.9	-1.2	-2.4	0.4	-0.2	-1.4
Lupus	1.1	1.6	3.4	-0.6	-1.7	0.4	1.1	1.9	1.2
Neuroticism (2016)	1.3	1.8	4.2	1.0	0.7	1.5	-1.3	-1.1	2.1
Primary Biliary Cirrhosis	2.1	3.1	7.1	-1.6	-1.7	-2.7	1.3	0.5	-2.0
Rheumatoid Arthritis	0.5	0.7	1.8	-0.3	0.9	-1.3	-0.9	-0.1	-0.8
Schizophrenia (2014)	3.9	8.6	22.8	2.1	0.1	4.8	-1.8	-1.7	4.3
Triglycerides	0.2	0.3	1.0	-0.6	-0.2	-0.3	0.0	-0.7	-1.0
Type 2 Diabetes (T2D) (2012)	1.2	1.4	3.4	-0.7	-0.7	-0.2	1.4	1.8	-1.5
Ulcerative Colitis	1.1	1.6	4.3	0.6	-0.2	2.1	1.6	1.4	0.6
Blood Eosinophil Count	0.1	0.7	1.5	-0.1	-0.6	-1.2	0.7	0.7	1.1
Blood Platelet Count	0.0	0.1	0.3	0.0	-0.5	-0.3	-0.4	-0.1	0.2
Blood Red Count	0.7	6.9	29.4	1.8	0.2	5.4	2.0	2.0	0.7
Blood White Count	0.5	4.0	9.9	3.1	2.5	2.5	-0.8	-0.9	-0.2
Heel T-Score	0.8	6.4	18.0	2.9	4.2	2.3	-2.5	-0.8	0.1
BMI	0.5	3.1	6.3	-2.0	-2.2	-1.4	2.5	1.2	0.5
Height	0.2	3.9	15.1	1.4	1.7	-3.9	-0.6	0.1	-1.8
Waist Hip Ratio (WHR)	5.2	23.3	54.5	7.4	5.1	6.7	-3.3	-1.6	1.1
Systolic Blood Pressure	0.3	1.7	3.5	-1.7	-0.8	-1.3	1.9	-0.2	-1.3
Smoking Status	0.3	0.7	1.5	-0.5	0.7	-0.8	0.4	1.1	-1.2
Allergy or Eczema	0.6	1.5	3.3	1.8	1.1	1.5	-0.9	0.1	1.0
Cardiovascular Disease	0.1	0.5	1.1	-0.7	-0.1	-0.7	0.3	-0.7	-1.1
Hypothyroidism (self reported)	0.1	0.2	0.5	0.7	0.3	0.2	-0.2	-0.5	0.7
Respiratory disease	0.1	0.3	1.2	0.3	0.1	0.2	-0.2	0.4	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.6	1.1	1.2	0.2	0.0	-0.0	-0.3
Lung FEV1/FVC ratio	0.7	3.6	7.7	-2.0	-1.1	-2.8	0.9	-1.0	-2.6
Lung FVC	0.1	0.3	1.3	-1.1	-0.3	-0.6	-0.3	-0.1	-0.2
Neuroticism	3.1	7.5	12.6	3.4	2.0	3.4	-1.9	-1.3	3.6
Chronotype (morning person)	0.6	1.3	5.6	1.0	2.4	-0.2	-0.8	0.3	-0.9
Hair Pigment	0.2	5.1	9.4	-0.4	-1.8	2.2	2.1	3.1	3.0
Tanning	0.2	1.9	4.7	-2.1	-0.9	-2.2	0.2	-0.1	-1.1
Hand grip strength (left)	1.3	3.5	7.4	2.4	2.7	0.7	-2.3	-1.5	0.2
Number of treatments/medications taken	0.5	1.0	3.0	1.0	0.7	1.7	0.6	0.1	0.9
Average weekly spirits intake	1.4	1.7	3.6	-1.5	-0.0	-1.9	1.3	0.9	-1.4
Sensitivity / hurt feelings	3.8	6.5	13.5	3.5	2.0	3.7	-1.2	-0.2	2.9
Frequency of depressed mood in last 2 weeks	2.8	4.0	6.7	2.5	2.2	2.6	-1.8	-1.1	1.3
Hearing difficulty/problems: Yes	1.3	2.0	6.5	0.3	-0.0	0.1	2.3	2.5	-0.1
Relative age of first facial hair	0.5	1.0	2.1	0.2	-1.0	1.5	0.7	0.6	1.4
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	6.9	1.2	0.1	2.6	-0.5	-0.3	2.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.5	-0.6	-0.4	0.4	1.2	1.2	-1.0
Ever had hysterectomy (womb removed)	0.8	0.9	2.3	-0.5	-1.0	0.7	1.2	1.5	-0.0
Systolic blood pressure, automated reading	1.6	4.5	11.4	-2.8	-2.1	-1.0	3.4	1.3	-1.1
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.1	0.1	0.8	0.7	1.1	0.4
Angina	0.2	0.3	0.9	0.2	0.2	0.6	0.7	0.1	0.9
Medication for hormone replacement therapy	0.6	0.7	1.6	-0.9	-1.3	-0.0	0.7	1.0	0.3
Vitamin and mineral supplements	1.1	1.5	5.4	0.4	-0.6	2.3	1.1	0.9	1.0
Supplements: Zinc	0.7	0.7	1.6	1.1	1.3	0.3	-1.0	0.3	-0.5
Medication: Co-codamol	1.4	1.6	4.2	1.4	2.0	0.6	-1.5	-0.9	-0.2
Medication: Metformin	0.5	0.7	1.6	1.1	0.5	1.2	0.7	0.8	0.5
Diabetes (father)	0.3	0.4	1.9	-0.2	0.1	-0.3	0.6	0.2	-1.4
Diabetes (mother)	2.9	3.7	7.7	2.8	2.1	2.4	-0.8	-0.4	1.9
Severe depression (siblings)	1.0	1.1	2.9	0.4	0.5	0.4	-1.7	-1.6	0.8
Pack years adult smoking proportion	1.4	2.1	8.0	1.3	0.6	2.8	1.3	1.0	-0.1
Impedance of leg (right)	1.5	7.2	18.7	4.3	3.5	1.2	-2.7	-1.9	-0.5
Leg fat-free mass (left)	0.5	2.8	6.0	-2.5	-2.0	-1.5	1.6	1.2	0.4
Trunk fat percentage	0.2	0.7	1.3	0.1	-1.2	0.7	1.0	-0.2	1.1
Hand grip strength (right)	1.3	3.6	8.1	1.9	2.8	-1.2	-2.4	-1.5	-0.6
Townsend deprivation index at recruitment	0.2	0.3	1.4	-0.0	0.4	0.2	-0.3	-0.4	-1.2
Current tobacco smoking	0.1	0.2	0.3	0.2	0.3	-0.3	-0.4	-0.5	-0.5
Average weekly fortified wine intake	0.1	0.1	0.3	0.2	0.1	-0.4	0.2	0.6	0.5
Maternal smoking around birth	1.8	2.5	6.4	0.7	0.5	2.5	1.6	2.2	0.7
Fed-up feelings	2.1	3.9	7.1	2.4	2.1	2.7	-1.6	-0.8	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	3.9	1.8	2.0	1.6	-1.7	-1.2	0.7
Relative age voice broke	0.7	1.0	2.5	-1.2	-1.3	-1.6	-0.2	-0.7	0.4
Taking other prescription medications	1.5	2.3	5.5	2.4	1.8	1.5	-0.7	-0.7	1.3
Age when periods started (menarche)	0.8	1.9	5.9	-0.1	1.3	-2.4	-1.6	-0.7	-0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	0.8	1.2	0.3	-0.6	-0.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.6	1.5	1.9	1.4	0.3	1.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.8	-0.3	-0.6	0.0	1.1	1.1	-1.4
Qualifications: CSEs or equivalent	1.9	2.5	5.8	2.2	2.4	1.5	-1.1	-0.9	0.3
Serious illness, injury or assault to yourself	1.1	1.3	2.1	1.2	1.5	1.4	-1.1	0.0	1.0
High blood pressure	0.1	0.2	1.0	-0.2	-0.1	0.2	-0.1	-1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.9	1.9	5.6	1.3	0.2	2.4	-0.4	0.4	1.9
Multivitamins +/- minerals	1.5	1.9	5.1	-0.1	1.2	-2.3	-0.9	-0.8	-1.8
Stomach or abdominal pain in last month	2.5	3.1	7.6	2.0	1.3	2.8	-1.1	-1.1	1.7
Supplements: Glucosamine	0.2	0.3	0.9	0.3	0.9	-0.2	0.3	0.4	-0.6
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	4.3	1.4	1.7	0.2	-2.1	-1.5	0.6
Medication: Atenolol	0.9	1.1	2.8	1.1	0.7	0.7	-1.1	-1.7	0.4
Medication: Levothyroxine sodium	0.4	0.6	3.0	0.0	-0.5	-0.2	-0.1	-0.7	1.7
Sitting height	0.4	2.9	5.7	-2.3	-1.8	-2.4	1.1	1.4	-0.5
Chronic bronchitis/emphysema (father)	1.0	1.1	1.7	1.1	1.3	1.2	-1.0	-0.3	1.2
High blood pressure (mother)	1.8	2.6	8.8	1.8	0.9	3.0	-0.1	0.3	1.5
Body mass index (BMI)	0.6	2.6	5.2	-1.8	-1.9	1.0	2.3	1.2	1.1
Impedance of leg (left)	1.0	4.9	14.1	3.8	2.8	1.1	-1.8	-1.1	-1.1
Leg predicted mass (left)	0.5	2.7	5.9	-2.4	-2.0	-1.5	1.5	1.1	0.5
Trunk fat mass	0.2	0.8	1.7	-0.4	-1.3	0.1	1.2	0.4	1.0
Waist circumference	0.5	1.8	7.3	1.1	0.0	2.7	0.6	0.2	1.5
Number of incorrect matches in round	0.7	1.1	4.3	1.2	0.5	2.1	-0.0	-0.1	0.8
Past tobacco smoking	0.3	0.6	2.5	0.4	-0.5	-0.0	-0.8	-1.6	0.4
Alcohol usually taken with meals	0.8	1.3	2.1	0.8	1.3	-0.8	-1.4	-1.4	-0.9
Nervous feelings	2.0	3.8	9.6	2.6	1.6	3.1	-0.9	-0.8	1.6
Frequency of tenseness / restlessness in last 2 weeks	3.9	6.1	17.4	2.3	1.3	4.2	-1.5	-0.8	3.1
Hearing difficulty/problems with background noise	0.8	1.3	3.9	1.1	0.5	1.3	0.8	2.0	0.6
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.9	-0.4	-0.3	0.2	0.4	-0.3
Had menopause	2.1	2.6	4.5	-1.8	-1.4	-0.9	2.1	1.8	-1.3
Had other major operations	0.2	0.3	1.3	-0.1	-0.5	-1.2	0.2	-0.2	0.2
Forced vital capacity (FVC)	0.2	0.6	1.6	0.8	1.2	-0.2	-1.0	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	6.7	2.2	2.6	1.3	0.0	1.1	0.2
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.5	1.1	-0.2	1.3	-1.9	-1.9	1.7
Qualifications: None of the above	0.6	1.2	5.6	0.6	2.4	0.1	-0.1	0.3	-1.0
Financial difficulties in last 2 years	1.1	1.5	4.0	-0.2	-0.9	2.0	1.0	1.2	1.2
Mouth/teeth dental problems	1.1	1.8	2.9	0.3	1.6	-0.7	-1.6	-1.7	-1.3
Heart attack	2.2	2.8	6.0	2.2	1.4	1.1	-1.5	-2.4	0.8
Allergy	1.5	3.4	8.0	-1.8	-0.5	-2.8	1.0	0.3	-2.8
Pain all over the body in last month	0.3	0.3	0.9	0.3	0.2	0.6	-0.5	-0.4	1.0
Diabetes (self-reported)	0.5	0.7	2.2	1.5	1.1	0.8	-0.1	-0.1	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.6	0.6	0.8	0.1	0.5	0.1
Medication: Ramipril	1.4	1.8	6.0	0.9	1.0	0.1	-1.6	-2.5	-0.7
Medication: Simvastatin	1.4	2.1	4.0	2.0	2.0	1.5	-1.2	-1.0	0.2
Fluid intelligence score	2.9	6.0	20.2	-2.7	-2.7	-4.5	0.8	0.7	-0.8
Illnesses of siblings	0.3	0.4	0.8	-0.5	-0.9	-0.5	-0.7	0.5	0.9
Neuroticism score	3.2	6.6	13.4	3.1	1.7	3.7	-1.6	-0.8	3.3
Weight	0.3	1.6	3.2	-1.4	-1.4	-0.5	1.8	1.4	0.6
Impedance of arm (right)	0.6	2.7	5.8	2.4	1.1	-0.9	-1.6	-1.9	-1.4
Arm fat percentage (right)	0.4	1.5	3.3	-0.8	-1.8	0.8	1.8	0.3	1.0
Trunk fat-free mass	0.2	1.3	2.8	-1.7	-0.9	-1.4	0.9	1.2	0.4
Hip circumference	0.9	3.9	8.9	-3.0	-2.7	-1.2	2.2	0.9	0.4
Time employed in main current job	1.7	2.0	5.5	1.8	2.3	1.7	-0.4	0.3	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.4	0.3	-0.0	-0.6	-0.5	0.2
Father’s age at death	1.9	2.6	6.1	-1.5	-2.5	-1.4	1.6	1.5	-0.6
Worrier / anxious feelings	5.4	10.2	16.1	4.0	2.8	3.6	-3.0	-2.2	3.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.7	0.4	0.0	1.0	-0.6	-0.3	1.9
Falls in the last year	1.8	2.5	8.6	1.0	-0.0	2.3	-0.3	0.2	2.9
Hair/balding pattern: Pattern 3	0.8	1.2	2.6	1.1	1.2	-0.7	-1.3	-1.6	0.4
Number of live births	2.8	4.0	5.5	1.9	1.7	1.6	-2.0	-2.2	2.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.0	0.3	0.8	-0.9	-1.0	-0.5	-0.9
Pulse rate	11.0	18.5	27.8	3.9	2.9	5.3	-4.7	-4.3	4.4
Happiness	1.6	2.0	4.6	1.4	0.7	0.3	-1.9	-2.1	1.0
Noisy workplace	0.8	0.9	1.9	0.8	1.4	-0.5	-0.9	-1.0	-1.0
Qualifications: A levels/AS levels or equivalent	1.4	3.0	5.5	-1.8	-2.3	-1.9	-1.0	-2.0	1.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.4	0.6	-0.2	1.5	-1.1	-1.5	1.6
Mouth/teeth dental problems: Dentures	0.2	0.4	1.1	0.6	-0.4	0.5	0.6	0.6	1.1
Asthma	0.4	0.8	1.7	0.9	1.3	0.1	-1.2	-0.7	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.1	-0.5	-1.1	-1.4	1.0	0.7	-0.5
Medication: Cholesterol lowering	0.6	1.0	2.5	1.0	0.8	0.0	-1.2	-1.6	0.7
Depression (self-reported)	2.7	3.2	7.8	1.6	0.6	2.8	-1.4	-1.4	2.1
Medication: Lansoprazole	1.0	1.1	2.1	1.2	1.4	0.5	-1.2	-1.2	0.4
Prospective memory result	0.3	0.3	0.9	0.6	0.4	0.1	-0.6	-0.9	0.5
Lung cancer (father)	0.8	1.0	3.0	0.4	0.9	-0.1	0.7	1.7	-1.1
Illnesses of mother	1.3	1.6	3.1	-1.1	-0.8	-1.8	-1.0	-1.4	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.1	0.4	0.6	-0.2	-1.1	-0.5	-0.5
Pulse wave Arterial Stiffness index	1.2	1.4	2.8	-1.6	-1.2	-0.6	1.7	0.9	-0.4
Impedance of arm (left)	0.5	2.4	5.5	2.3	0.8	-0.9	-1.5	-1.9	-1.2
Arm fat mass (right)	0.5	1.9	4.1	-1.4	-2.0	0.4	1.9	0.8	1.0
Trunk predicted mass	0.3	1.5	3.0	-1.7	-1.0	-1.4	1.0	1.3	0.3
Standing height	0.2	2.1	10.1	0.7	0.7	-3.2	-0.9	0.2	-0.8
Length of working week for main job	1.2	1.4	3.4	-0.2	-0.5	1.2	1.7	1.9	-0.4
Exposure to tobacco smoke at home	1.6	1.8	3.9	1.0	0.1	1.7	-1.1	-1.2	2.0
Breastfed as a baby	0.7	0.9	2.6	-0.1	0.7	-1.6	-1.1	-0.7	-0.6
Tense / ‘highly strung’	0.5	0.8	1.7	1.2	1.3	1.2	-0.0	0.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	4.4	6.7	15.9	3.3	2.3	4.0	-1.7	-0.6	2.1
Hair/balding pattern: Pattern 4	1.0	2.4	9.6	-1.1	-0.5	-3.1	0.5	0.1	-1.8
Birth weight of first child	0.3	0.5	2.3	0.1	-0.2	-1.5	-0.3	0.1	-0.5
Peak expiratory flow (PEF)	0.7	1.7	4.6	-0.4	1.0	-2.1	-0.1	0.3	-2.1
Pulse wave reflection index	1.4	1.7	3.6	-1.1	-0.5	-1.4	1.9	1.6	-0.7
Ever highly irritable/argumentative for 2 days	0.6	0.8	2.6	-0.0	0.2	-1.6	-0.9	-1.0	-0.0
Loud music exposure frequency	0.9	1.0	2.5	-0.2	-1.4	0.4	1.6	1.0	0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.1	-0.0	-0.7	-1.4	-0.9	-0.9	0.4
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	3.8	-1.3	-2.0	1.0	1.8	1.4	0.6
Blood clot in the leg (DVT)	1.5	1.9	3.2	1.4	1.8	0.6	-1.5	-1.4	1.3
Medication: Paracetamol	0.4	0.6	1.5	0.5	-0.2	1.2	-0.6	-0.7	1.0
Headache pain in last month	3.5	6.0	11.3	3.1	2.1	3.4	-1.3	-1.0	2.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.2	-1.0	-0.9	-0.6	0.7	1.1	-0.6
Glaucoma (self-reported)	1.4	1.6	6.7	0.9	0.7	2.6	0.6	1.2	0.3
Gout (self-reported)	3.3	4.6	17.0	1.6	0.6	4.1	0.1	1.0	2.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	-0.2	-0.5	-0.5	0.6	0.2	0.8
Medication: Amlodipine	1.4	1.9	6.1	-0.2	-0.9	2.1	0.5	0.2	2.5
Medication: Ventolin 100micrograms inhaler	0.8	1.1	1.6	0.8	1.3	1.2	-1.1	-0.9	0.8
Birth weight	0.3	0.6	1.4	-0.7	-0.7	-1.2	-0.6	-0.9	0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	5.1	0.9	2.3	-1.2	-0.7	0.0	-0.7
High blood pressure (siblings)	0.9	1.3	2.8	-1.5	-1.5	-0.3	1.7	0.4	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.4	0.9	0.9	0.7	0.6	-0.9	0.1	0.3
Body fat percentage	0.2	0.8	1.8	-0.1	-1.1	0.8	1.3	0.2	1.1
Leg fat percentage (right)	0.2	0.5	1.4	0.1	-0.3	1.0	1.2	0.3	0.9
Arm fat-free mass (right)	0.2	0.9	1.8	-1.4	-0.7	-0.5	0.8	1.3	0.8
Exposure to tobacco smoke outside home	0.5	0.6	1.8	0.9	0.3	1.4	-0.4	-0.4	0.8
Comparative body size at age 10	0.5	1.5	3.6	-1.5	-1.9	-1.4	-0.2	-1.1	-0.2
Number of full brothers	0.2	0.3	1.4	-0.2	-0.5	0.4	0.2	-0.1	1.2
Worry too long after embarrassment	1.8	3.1	9.1	1.3	0.2	2.7	-0.2	0.4	3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	2.2	1.2	0.9	1.5	-0.7	0.0	0.5
Wheeze or whistling in the chest in last year	1.6	2.8	5.6	2.2	1.9	2.4	-0.3	0.3	1.6
Number of children fathered	1.1	1.2	3.5	-0.7	0.7	-1.9	0.6	0.8	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	0.8	0.5	-0.0	-0.2	0.0	-1.0
Age at first live birth	1.1	1.9	4.6	-1.3	-1.6	-2.2	0.9	0.9	-0.9
Pulse wave peak to peak time	0.8	1.0	2.1	1.4	1.0	0.3	-1.4	-0.6	0.3
Health satisfaction	0.8	1.0	2.2	1.5	1.3	0.9	-0.8	-1.0	-0.3
Shortness of breath walking on level ground	0.9	1.0	2.5	0.9	1.6	0.9	-1.0	-1.0	0.1
Qualifications: College or University degree	1.8	5.8	20.7	-0.0	-3.1	1.4	-0.8	-1.1	4.5
Eye problems/disorders: None of the above	2.6	3.0	7.4	-0.8	0.7	-2.7	-1.2	-1.2	-2.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.9	0.4	-0.0	0.5	-0.8	-1.4	0.6
Emphysema/chronic bronchitis	0.4	0.4	2.1	0.1	-0.1	-0.2	-0.3	-0.4	1.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.8	-0.8	-0.5	-1.3	-0.2	0.5	-0.6
Neck or shoulder pain in last month	1.3	1.9	5.3	-1.0	-0.2	-1.0	1.6	2.3	-1.1
Medication: Blood pressure	0.3	0.5	1.0	1.0	0.6	0.9	0.0	-0.8	0.5
Angina (self-reported)	0.2	0.3	0.7	0.3	0.3	0.7	0.7	0.1	0.8
Migraine (self-reported)	0.8	1.0	2.9	-0.9	-1.7	0.2	0.3	0.3	1.5
Medication: Ibuprofen	1.4	1.7	4.0	-1.2	-1.5	-2.0	1.3	0.9	-0.3
Medication: Allopurinol	3.0	4.0	11.7	2.2	2.1	3.4	-0.4	0.7	1.6
Medication: Omeprazole	1.4	1.6	5.7	0.1	-0.5	1.5	-0.8	-0.9	2.4
Medication: Seretide 50 evohaler	0.9	1.1	2.7	1.2	1.1	1.7	-0.5	-0.1	0.9
Mean time to correctly identify matches	2.5	4.7	7.7	-2.8	-2.4	-2.4	2.3	1.8	-0.7
Heart disease (mother)	0.4	0.5	1.4	-0.0	0.0	-0.1	0.7	1.1	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.9	0.1	0.8	-0.7	-0.2	-0.6	-0.9
Whole body fat mass	0.3	1.3	2.6	-0.8	-1.6	0.3	1.6	0.8	1.1
Leg fat mass (right)	0.4	1.5	3.7	-1.2	-1.5	0.1	1.9	1.1	0.6
Arm predicted mass (right)	0.2	1.2	2.6	-1.6	-0.9	-0.6	1.0	1.3	0.8
Pulse rate, automated reading	9.8	31.7	45.2	5.2	2.7	6.4	-6.1	-5.8	6.7
Alcohol intake frequency.	1.0	2.2	4.9	2.2	1.6	1.5	-1.0	-1.6	-0.0
Comparative height size at age 10	0.2	1.2	6.2	-0.2	0.3	-2.5	-0.8	0.3	-0.2
Number of full sisters	1.0	1.3	3.3	1.8	1.3	1.4	-0.3	-0.2	0.7
Suffer from ‘nerves’	1.9	2.9	6.1	2.5	2.0	2.4	-0.9	-0.6	0.7
Overall health rating	2.4	5.2	11.8	3.4	3.0	1.9	-1.8	-1.6	0.6
Chest pain or discomfort	1.2	1.7	5.9	1.5	0.9	2.4	-0.2	0.2	1.1
Had major operations	1.0	1.1	3.7	0.7	0.2	0.3	-1.3	-1.9	0.9
Age at last live birth	0.5	0.8	1.7	-0.6	-0.9	-0.9	0.8	1.3	-0.7
Family relationship satisfaction	1.9	2.4	4.5	2.1	1.3	1.7	-1.4	-1.1	1.4
Leg pain on walking	2.1	2.6	6.7	1.9	1.4	2.6	-0.3	-0.4	1.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	3.4	-0.4	-1.2	1.5	1.8	1.3	-0.1
Commuting to job workplace: Car/motor vehicle	1.3	1.5	6.0	0.7	0.2	0.5	-1.2	-0.7	2.4
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	9.2	-0.9	-0.1	-3.0	0.6	0.0	-2.0
Medication: Aspirin	0.4	0.5	2.6	0.2	0.1	1.6	0.4	-0.3	0.4
Supplements: Vitamin C	0.8	1.0	2.0	0.2	0.9	-1.4	-1.1	-1.1	-0.8
Knee pain experienced in last month	0.7	1.0	3.7	-0.8	0.6	-0.7	0.9	0.3	-1.9
Hypertension (Self-reported)	0.1	0.3	1.1	-0.5	-0.3	-0.1	-0.0	-1.1	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.3	0.1	-0.7	-0.4	-0.5	0.1
Illnesses of father: Heart disease	0.6	0.9	2.9	-1.7	-1.2	0.4	0.4	-0.6	0.3
Illnesses of siblings: Diabetes	3.3	4.1	9.6	1.7	3.1	-0.7	-1.9	-2.4	-1.5
Smoking status: Previous	0.9	1.3	5.2	-0.3	0.6	0.2	1.3	2.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.4	0.2	0.1	0.2	-0.6	0.4	0.5
Whole body fat-free mass	0.3	1.8	4.0	-2.0	-1.4	-1.2	1.3	1.4	0.5
Leg fat-free mass (right)	0.6	3.2	7.0	-2.6	-2.2	-1.5	1.8	1.4	0.2
Arm fat percentage (left)	0.4	1.5	3.5	-0.8	-1.9	0.9	1.7	0.2	1.1
Average weekly red wine intake	0.6	0.9	2.9	-1.7	-0.6	-0.5	0.8	1.0	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	0.5	0.6	0.3	-0.7	-1.0	-0.4
Mood swings	2.3	4.2	9.4	2.7	2.5	3.1	-1.0	-0.1	1.1
Loneliness, isolation	1.6	2.2	5.0	1.6	1.0	1.9	-1.1	0.1	2.2
Long-standing illness, disability or infirmity	0.4	0.7	1.4	0.1	-0.4	1.1	1.1	0.3	1.2
Ever had bowel cancer screening	0.4	0.5	1.8	0.8	1.3	-0.1	-0.4	0.4	-0.6
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.8	0.6	0.0	0.7	0.5	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	0.7	1.0	0.1	0.6	0.4	-0.9
Friendships satisfaction	1.3	1.6	2.3	1.3	1.5	-0.7	-1.3	-1.5	-1.0
Qualifications: nursing, teaching	1.1	1.7	3.9	0.6	-0.5	-1.3	-1.7	-2.0	1.2
Commuting to job workplace: Walk	0.9	0.9	2.5	-1.6	-1.3	0.5	0.3	-0.3	-1.1
Eye problems/disorders: Cataract	1.9	2.2	5.7	1.2	-0.4	2.4	0.3	-0.3	2.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.0	-0.7	-1.0	-0.7	0.9	0.8	0.3
Medication for cholesterol	0.6	0.9	3.2	1.2	1.8	0.1	-0.2	0.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.6	1.1	0.9	1.2	0.3	0.2	0.0
Back pain experienced in last month	0.8	1.2	4.6	-0.6	0.6	-2.1	0.4	0.2	-1.4
Mineral and other dietary supplements	1.3	1.7	4.2	1.2	0.1	1.9	-1.0	-0.2	2.1
Breast cancer (self-reported)	0.1	0.2	0.4	-0.1	-0.4	-0.7	-0.2	0.5	0.1
Asthma (self-reported)	0.2	0.4	0.9	0.7	1.0	0.2	-0.8	-0.4	0.6
Osteoporosis (self-reported)	0.6	0.8	3.3	0.4	-0.4	0.4	-0.6	-1.8	0.8
Osteoarthritis (self-reported)	0.4	0.5	0.9	-0.9	-0.0	-0.9	-0.3	-0.8	-0.7
Medication: Aspirin	0.4	0.5	2.0	-0.3	-0.3	1.4	0.7	-0.3	-0.0
Medication: Gliclazide	0.1	0.1	0.2	0.5	0.3	0.1	0.3	0.0	-0.1
Illnesses of father: None of the above (group 1)	2.6	3.2	7.5	2.6	2.7	-0.4	-1.9	-0.6	-0.4
Smoking status: Current	0.2	0.3	0.6	0.1	0.5	-0.4	-0.7	-0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.7	1.1	1.6	0.3	-1.6	-1.2	0.2
Whole body water mass	0.3	1.6	3.7	-1.9	-1.3	-1.2	1.2	1.2	0.5
Leg predicted mass (right)	0.6	3.0	6.7	-2.6	-2.1	-1.4	1.7	1.3	0.2
Arm fat mass (left)	0.4	1.8	3.8	-1.4	-1.9	0.2	1.9	0.9	0.8
Number of self-reported non-cancer illnesses	0.3	0.4	1.2	0.7	0.5	0.7	-0.3	-0.3	1.1
Average weekly champagne plus white wine intake	1.0	1.3	2.9	-1.4	-1.5	-1.7	0.5	0.4	-0.4
Miserableness	1.7	2.9	4.9	1.2	0.8	2.2	-2.2	-1.2	2.0
Guilty feelings	2.2	3.3	10.4	1.4	0.4	2.1	-1.4	-1.1	3.2
Wears glasses or contact lenses	1.9	2.2	10.6	-0.5	-0.7	-3.3	-0.5	-1.2	-0.2
Ever taken oral contraceptive pill	0.6	0.7	3.0	0.5	-0.6	0.6	-0.5	-0.1	1.7
Hearing aid user	1.8	2.0	5.0	-1.5	-0.5	-2.2	0.7	0.7	-1.8
Mother’s age at death	3.5	4.3	8.4	-2.0	-2.5	-2.9	1.9	1.6	-1.2
Financial situation satisfaction	0.6	0.7	2.1	1.1	0.9	1.4	-0.1	-0.0	0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	0.8	0.4	0.7	0.3	0.4	-0.5
Commuting to job workplace: Public transport	0.5	0.6	2.4	-0.5	0.3	-1.6	-0.0	-0.1	-0.9
Eye problems/disorders: Glaucoma	2.9	3.4	11.2	0.9	-0.2	3.4	1.5	1.9	1.6
Medication: Blood pressure	0.6	1.2	4.3	-0.6	-0.9	0.4	-1.2	-2.1	0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.5	0.0	0.0	1.2	1.0	1.0	0.4
Supplements: Fish oil (including cod liver oil)	0.8	1.1	4.0	-0.8	0.2	-1.0	1.0	0.2	-2.0
High cholesterol (Self-reported)	0.1	0.2	0.6	0.6	0.8	0.2	0.1	0.5	0.1
Medication: Bendroflumethiazide	0.3	0.5	0.9	-0.9	-0.6	-0.7	0.4	-0.1	-1.0
Medication: Paracetamol	0.6	0.9	3.1	0.3	-0.5	1.4	-0.1	-0.1	1.7
Medication: Lisinopril	0.6	0.8	1.5	1.0	1.2	0.8	-1.1	-0.8	0.0
Medication: Atorvastatin	0.1	0.1	0.3	-0.0	-0.4	0.4	0.3	-0.5	0.2
Illnesses of father: High blood pressure	1.4	1.7	4.8	-1.6	-2.2	1.2	0.9	0.3	0.8
Alcohol drinker status: Never	1.9	2.3	5.3	1.3	0.6	2.3	-0.4	-1.8	1.7
Ever smoked	0.1	0.1	0.5	-0.4	0.1	-0.1	0.0	0.7	-0.3
Basal metabolic rate	0.3	1.8	3.6	-1.9	-1.4	-1.1	1.4	1.3	0.5
Leg fat percentage (left)	0.3	0.9	3.2	-0.2	-0.6	0.9	1.8	0.9	0.3
Arm fat-free mass (left)	0.3	1.6	3.0	-1.7	-1.0	-0.4	1.5	1.7	0.6
Number of operations (self-reported)	0.4	0.6	1.3	0.8	0.9	-0.7	-0.6	-1.2	-0.1
Average weekly beer plus cider intake	1.8	2.6	7.7	1.5	0.6	2.8	-0.1	-0.2	2.3
Irritability	0.2	0.4	1.7	0.0	-0.3	1.3	0.4	0.1	0.6
Risk taking	2.1	3.1	11.0	2.0	1.6	3.3	-0.6	0.1	0.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.8	-0.6	-0.2	-1.7	0.8	0.2	-1.2
Fractured/broken bones in last 5 years	3.0	3.8	8.3	-2.6	-2.9	-0.9	2.2	1.5	0.1
Age started oral contraceptive pill	0.8	1.0	1.8	-0.8	-0.9	-1.2	-1.0	-1.3	0.5
Diastolic blood pressure, automated reading	1.2	3.7	16.5	1.2	0.6	4.1	0.9	0.1	1.8
Ever depressed for a whole week	1.0	1.2	2.2	1.1	-0.0	0.5	-1.2	-1.5	1.5
Unable to work because of sickness or disability	0.9	1.1	3.8	0.8	0.8	1.9	-0.5	-0.5	1.0
Commuting to job workplace: Cycle	0.2	0.3	0.6	-0.2	0.6	-0.8	-0.7	-0.2	-0.5
Myopia	2.3	3.4	8.7	-0.3	-0.7	-2.0	-2.6	-3.0	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.9	-0.5	-0.5	-0.9	0.6	1.7	-0.5
Cholesterol lowering medication	0.4	0.6	1.6	1.1	0.6	1.3	0.7	0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	4.0	-0.0	-0.6	1.0	-0.7	-1.0	2.0
Pain experienced in last month	0.5	0.9	1.8	-0.1	-0.7	0.7	-1.2	-1.1	1.3
Supplements: Calcium	0.9	1.0	2.8	-0.2	0.1	-1.0	-1.4	-1.7	-0.5
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.2	-0.1	-0.1	0.2	0.1	-0.6
Heart attack/myocardial infarction (self-reported)	1.6	2.0	4.8	1.9	1.2	0.8	-1.2	-2.2	0.3
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.0	1.3	1.7	0.4	-1.5	-1.5	0.9
Heart disease (siblings)	0.9	1.1	3.8	1.1	0.7	1.9	0.4	-0.1	1.1
Alcohol drinker status: Previous	0.2	0.2	0.6	0.2	-0.4	0.3	-0.2	-0.5	0.8
Pack years of smoking	1.1	1.6	5.2	1.1	0.4	2.3	1.4	0.9	-0.2
Impedance of whole body	0.8	4.1	11.6	3.4	2.1	0.3	-2.0	-1.8	-1.1
Leg fat mass (left)	0.5	2.1	5.2	-1.4	-1.7	0.1	2.3	1.4	0.4
Arm predicted mass (left)	0.3	1.3	2.8	-1.5	-0.7	-0.5	1.3	1.7	0.7