[Hub]/) : Traits : Miserableness :

chr11:46,010,847-48,559,571

Best TWAS P=1.52e-14 · Best GWAS P=9.2e-13 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LRP4 0.04 0.05 lasso 4 0.04 6.6e-06 -5.2 -5.6 2.3e-08 0.56 0.83 0.16 FALSE
2 GTEx Adipose Subcutaneous ARHGAP1 0.08 0.03 lasso 6 0.05 3.4e-05 -5.7 5.2 2.1e-07 -0.61 0.30 0.64 TRUE
3 GTEx Artery Tibial ZNF408 0.10 0.00 lasso 6 0.04 2.0e-04 -3.4 5.6 2.2e-08 -0.64 0.17 0.54 FALSE
4 GTEx Brain Cerebellar Hemisphere RP11-750H9.5 0.17 0.25 lasso 6 0.21 3.5e-06 6.0 -6.0 1.5e-09 0.39 0.23 0.50 FALSE
5 GTEx Brain Cortex MTCH2 0.21 0.19 lasso 6 0.16 4.0e-05 -5.7 -5.2 2.5e-07 0.13 0.40 0.08 FALSE
6 GTEx Brain Cortex C1QTNF4 0.26 0.04 lasso 8 0.02 1.2e-01 5.6 6.4 1.4e-10 -0.33 0.05 0.08 FALSE
7 GTEx Breast Mammary Tissue ARHGAP1 0.05 0.00 enet 14 0.01 1.3e-01 -3.4 5.2 1.9e-07 -0.60 0.14 0.09 FALSE
8 GTEx Cells Transformed fibroblasts FNBP4 0.11 0.05 lasso 8 0.08 1.6e-06 5.3 -5.7 1.1e-08 0.27 0.92 0.08 FALSE
9 GTEx Esophagus Gastroesophageal Junction NUP160 0.18 0.02 enet 18 0.11 7.1e-05 3.6 -6.6 5.4e-11 0.35 0.05 0.82 FALSE
10 GTEx Esophagus Mucosa ARFGAP2 0.05 0.06 lasso 4 0.05 4.4e-04 -5.3 -5.2 2.1e-07 0.71 0.23 0.32 TRUE
11 GTEx Esophagus Muscularis MTCH2 0.09 0.04 lasso 6 0.02 1.8e-02 -5.7 -6.8 1.4e-11 0.30 0.40 0.29 FALSE
12 GTEx Esophagus Muscularis MADD 0.13 0.07 enet 8 0.11 2.0e-07 4.4 -5.8 8.2e-09 0.41 0.01 0.98 FALSE
13 GTEx Liver C1QTNF4 0.25 0.14 enet 16 0.20 2.3e-06 -3.8 6.0 1.6e-09 -0.32 0.42 0.25 FALSE
14 GTEx Pancreas LRP4 0.11 0.10 enet 16 0.14 1.8e-06 -5.3 5.5 3.0e-08 -0.71 0.22 0.76 FALSE
15 GTEx Pituitary MADD 0.42 0.32 lasso 6 0.39 8.9e-11 7.0 -7.7 1.5e-14 0.44 0.01 0.98 TRUE
16 GTEx Prostate CELF1 0.17 0.16 lasso 2 0.12 6.2e-04 -5.3 -5.3 1.1e-07 0.52 0.15 0.22 FALSE
17 GTEx Skin Sun Exposed Lower leg DDB2 0.08 0.10 lasso 4 0.10 5.8e-09 -5.4 -5.8 9.0e-09 0.67 0.97 0.03 TRUE
18 GTEx Skin Sun Exposed Lower leg C1QTNF4 0.25 0.22 lasso 12 0.23 4.2e-19 -3.8 5.4 7.7e-08 -0.21 0.98 0.02 FALSE
19 GTEx Spleen C1QTNF4 0.31 0.28 enet 29 0.34 1.8e-09 -5.7 6.1 1.3e-09 -0.23 0.90 0.05 FALSE
20 GTEx Testis C1QTNF4 0.14 0.12 lasso 4 0.11 1.6e-05 5.4 6.4 1.4e-10 -0.44 0.59 0.30 FALSE
21 GTEx Whole Blood C1QTNF4 0.09 0.05 lasso 3 0.03 1.4e-03 -5.7 5.6 2.0e-08 -0.17 0.60 0.07 FALSE
22 METSIM Adipose C1QTNF4 0.24 0.31 lasso 7 0.31 1.2e-46 -5.7 5.5 3.2e-08 -0.16 0.93 0.07 FALSE
23 METSIM Adipose DDB2 0.03 0.03 lasso 2 0.02 1.9e-04 -5.3 5.6 2.4e-08 -0.57 0.15 0.82 TRUE
24 METSIM Adipose NR1H3 0.03 0.03 lasso 6 0.04 4.7e-06 5.5 -6.7 3.0e-11 0.51 0.07 0.91 TRUE
25 NTR Blood MTCH2 0.02 0.04 lasso 1 0.04 1.3e-11 -5.7 5.7 1.6e-08 -0.18 0.92 0.08 FALSE
26 ROSMAP Brain Pre-frontal Cortex MTCH2 0.35 0.40 enet 9 0.40 4.7e-56 -5.7 -5.5 2.9e-08 0.17 0.94 0.06 FALSE
27 ROSMAP Brain Pre-frontal Cortex FNBP4 0.04 0.04 lasso 3 0.04 8.2e-06 5.4 -6.2 4.8e-10 0.36 0.73 0.27 TRUE
28 YFS Blood FNBP4 0.02 0.01 bslmm 301 0.01 8.9e-05 5.9 -5.3 1.1e-07 0.31 0.30 0.53 FALSE
29 The Cancer Genome Atlas Bladder Urothelial Carcinoma C1QTNF4 0.06 0.07 lasso 2 0.06 4.9e-06 -5.7 5.3 9.8e-08 -0.16 0.11 0.88 FALSE
30 The Cancer Genome Atlas Colon Adenocarcinoma NUP160 0.05 0.05 blup 44 0.05 7.7e-04 5.4 -5.1 2.8e-07 0.26 0.07 0.35 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma PSMC3 0.09 0.05 blup 39 0.05 1.0e-03 6.0 -6.1 9.0e-10 0.32 0.02 0.79 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C1QTNF4 0.06 0.08 lasso 3 0.08 7.5e-09 -5.7 5.7 1.1e-08 -0.17 0.10 0.90 FALSE
33 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FNBP4 0.10 0.03 blup 45 0.05 7.7e-06 -5.7 -5.3 1.3e-07 0.17 0.03 0.92 FALSE
34 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma NUP160 0.08 0.03 blup 42 0.04 6.7e-05 -5.9 -5.3 1.1e-07 0.17 0.02 0.92 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C1QTNF4 0.12 0.14 enet 4 0.16 6.5e-18 -5.7 5.1 2.7e-07 -0.16 0.09 0.91 FALSE
36 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C1QTNF4 0.13 0.16 lasso 1 0.16 3.1e-09 -5.7 5.7 1.4e-08 -0.18 0.10 0.90 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma MTCH2 0.11 0.11 lasso 2 0.10 6.4e-12 -5.7 -5.7 1.0e-08 0.17 0.10 0.90 FALSE
38 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C1QTNF4 0.19 0.19 lasso 3 0.19 3.2e-09 -5.7 5.7 1.0e-08 -0.17 0.10 0.90 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma NUP160 0.03 0.02 enet 7 0.02 6.3e-03 -6.2 -6.8 1.4e-11 0.28 0.01 0.91 FALSE
40 The Cancer Genome Atlas Stomach Adenocarcinoma C1QTNF4 0.06 0.04 lasso 4 0.03 4.3e-03 -5.7 5.3 1.1e-07 -0.16 0.04 0.49 FALSE