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chr11:46,010,847-48,559,571

Best TWAS P=1.52e-14 · Best GWAS P=9.2e-13 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LRP4	0.04	0.05	lasso	4	0.04	6.6e-06	-5.2	-5.6	2.3e-08	0.56	0.83	0.16	FALSE
2	GTEx	Adipose Subcutaneous	ARHGAP1	0.08	0.03	lasso	6	0.05	3.4e-05	-5.7	5.2	2.1e-07	-0.61	0.30	0.64	TRUE
3	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	-3.4	5.6	2.2e-08	-0.64	0.17	0.54	FALSE
4	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	6.0	-6.0	1.5e-09	0.39	0.23	0.50	FALSE
5	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-5.7	-5.2	2.5e-07	0.13	0.40	0.08	FALSE
6	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	5.6	6.4	1.4e-10	-0.33	0.05	0.08	FALSE
7	GTEx	Breast Mammary Tissue	ARHGAP1	0.05	0.00	enet	14	0.01	1.3e-01	-3.4	5.2	1.9e-07	-0.60	0.14	0.09	FALSE
8	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	5.3	-5.7	1.1e-08	0.27	0.92	0.08	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	NUP160	0.18	0.02	enet	18	0.11	7.1e-05	3.6	-6.6	5.4e-11	0.35	0.05	0.82	FALSE
10	GTEx	Esophagus Mucosa	ARFGAP2	0.05	0.06	lasso	4	0.05	4.4e-04	-5.3	-5.2	2.1e-07	0.71	0.23	0.32	TRUE
11	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-5.7	-6.8	1.4e-11	0.30	0.40	0.29	FALSE
12	GTEx	Esophagus Muscularis	MADD	0.13	0.07	enet	8	0.11	2.0e-07	4.4	-5.8	8.2e-09	0.41	0.01	0.98	FALSE
13	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-3.8	6.0	1.6e-09	-0.32	0.42	0.25	FALSE
14	GTEx	Pancreas	LRP4	0.11	0.10	enet	16	0.14	1.8e-06	-5.3	5.5	3.0e-08	-0.71	0.22	0.76	FALSE
15	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	7.0	-7.7	1.5e-14	0.44	0.01	0.98	TRUE
16	GTEx	Prostate	CELF1	0.17	0.16	lasso	2	0.12	6.2e-04	-5.3	-5.3	1.1e-07	0.52	0.15	0.22	FALSE
17	GTEx	Skin Sun Exposed Lower leg	DDB2	0.08	0.10	lasso	4	0.10	5.8e-09	-5.4	-5.8	9.0e-09	0.67	0.97	0.03	TRUE
18	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-3.8	5.4	7.7e-08	-0.21	0.98	0.02	FALSE
19	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-5.7	6.1	1.3e-09	-0.23	0.90	0.05	FALSE
20	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	5.4	6.4	1.4e-10	-0.44	0.59	0.30	FALSE
21	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-5.7	5.6	2.0e-08	-0.17	0.60	0.07	FALSE
22	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-5.7	5.5	3.2e-08	-0.16	0.93	0.07	FALSE
23	METSIM	Adipose	DDB2	0.03	0.03	lasso	2	0.02	1.9e-04	-5.3	5.6	2.4e-08	-0.57	0.15	0.82	TRUE
24	METSIM	Adipose	NR1H3	0.03	0.03	lasso	6	0.04	4.7e-06	5.5	-6.7	3.0e-11	0.51	0.07	0.91	TRUE
25	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-5.7	5.7	1.6e-08	-0.18	0.92	0.08	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-5.7	-5.5	2.9e-08	0.17	0.94	0.06	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	5.4	-6.2	4.8e-10	0.36	0.73	0.27	TRUE
28	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	5.9	-5.3	1.1e-07	0.31	0.30	0.53	FALSE
29	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-5.7	5.3	9.8e-08	-0.16	0.11	0.88	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	5.4	-5.1	2.8e-07	0.26	0.07	0.35	FALSE
31	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	6.0	-6.1	9.0e-10	0.32	0.02	0.79	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-5.7	5.7	1.1e-08	-0.17	0.10	0.90	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-5.7	-5.3	1.3e-07	0.17	0.03	0.92	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-5.9	-5.3	1.1e-07	0.17	0.02	0.92	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-5.7	5.1	2.7e-07	-0.16	0.09	0.91	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-5.7	5.7	1.4e-08	-0.18	0.10	0.90	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-5.7	-5.7	1.0e-08	0.17	0.10	0.90	FALSE
38	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-5.7	5.7	1.0e-08	-0.17	0.10	0.90	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-6.2	-6.8	1.4e-11	0.28	0.01	0.91	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-5.7	5.3	1.1e-07	-0.16	0.04	0.49	FALSE