Hub : Genes

CTSB

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1260 0.0390 1.4e-08 0.098 0.070 0.095 0.088 0.094 6.4e-12 6.7e-09 1.4e-11 6.6e-11 1.5e-11
2 GTEx Brain Nucleus accumbens basal ganglia 0.4130 0.1260 2.7e-03 0.077 NA 0.134 NA 0.077 4.3e-03 NA 1.9e-04 NA 4.3e-03
3 GTEx Cells Transformed fibroblasts 0.4600 0.0590 6.3e-15 0.123 NA 0.323 NA 0.320 1.8e-09 NA 7.7e-25 NA 1.7e-24
4 GTEx Esophagus Mucosa 0.1600 0.0560 1.8e-03 0.043 NA 0.141 NA 0.121 6.8e-04 NA 1.1e-09 NA 1.7e-08
5 GTEx Esophagus Muscularis 0.4030 0.0700 1.8e-08 0.183 NA 0.204 NA 0.223 2.6e-11 NA 1.7e-12 NA 1.1e-13
6 GTEx Heart Atrial Appendage 0.2590 0.0740 2.3e-04 0.077 NA 0.092 NA 0.108 2.5e-04 NA 6.6e-05 NA 1.5e-05
7 GTEx Nerve Tibial 0.4091 0.0692 6.3e-09 0.086 NA 0.110 NA 0.115 1.1e-06 NA 3.4e-08 NA 1.6e-08
8 GTEx Skin Not Sun Exposed Suprapubic 0.2170 0.0840 2.6e-03 0.055 NA 0.031 NA 0.068 5.7e-04 NA 8.3e-03 NA 1.4e-04
9 GTEx Skin Sun Exposed Lower leg 0.1580 0.0490 5.9e-04 0.049 NA 0.046 NA 0.028 6.7e-05 NA 9.9e-05 NA 2.2e-03
10 GTEx Spleen 0.4160 0.1390 1.2e-03 0.238 NA 0.200 NA 0.148 8.5e-07 NA 7.6e-06 NA 1.2e-04
11 GTEx Testis 0.1710 0.0650 4.8e-03 0.166 NA 0.118 NA 0.151 7.6e-08 NA 7.0e-06 NA 3.4e-07
12 GTEx Whole Blood 0.1180 0.0400 3.5e-04 0.036 NA 0.063 NA 0.064 2.6e-04 NA 1.8e-06 NA 1.6e-06
13 METSIM Adipose 0.0792 0.0261 2.9e-04 0.013 0.023 0.015 0.026 0.019 4.4e-03 2.0e-04 2.2e-03 6.3e-05 7.1e-04
14 NTR Blood 0.0364 0.0143 1.7e-03 0.007 0.010 0.008 0.010 0.009 1.8e-03 3.2e-04 7.9e-04 1.9e-04 4.0e-04
15 ROSMAP Brain Pre-frontal Cortex 0.1762 0.0360 0.0e+00 0.142 0.167 0.169 0.170 0.166 8.7e-18 6.6e-21 3.8e-21 3.0e-21 7.7e-21
16 YFS Blood 0.4935 0.0350 0.0e+00 0.131 0.395 0.428 0.393 0.406 1.4e-40 7.8e-140 1.3e-155 6.9e-139 4.5e-145
17 TCGA Bladder Urothelial Carcinoma 0.0470 0.0250 2.7e-03 0.016 0.020 0.021 NA 0.015 1.4e-02 7.2e-03 5.8e-03 NA 1.8e-02
18 TCGA Breast Invasive Carcinoma 0.0405 0.0152 3.6e-09 0.041 0.048 0.040 NA 0.043 7.3e-09 3.4e-10 1.0e-08 NA 2.8e-09
19 TCGA Kidney Renal Clear Cell Carcinoma 0.0465 0.0201 3.5e-04 0.016 0.033 0.030 NA 0.020 5.9e-03 1.0e-04 2.2e-04 NA 2.0e-03
20 TCGA Brain Lower Grade Glioma 0.0357 0.0173 9.3e-04 0.009 0.027 0.016 NA 0.017 3.2e-02 4.5e-04 6.1e-03 NA 4.4e-03
21 TCGA Lung Adenocarcinoma 0.0645 0.0271 4.0e-05 0.040 0.045 0.032 NA 0.033 1.6e-05 4.5e-06 1.1e-04 NA 8.0e-05
22 TCGA Prostate Adenocarcinoma 0.0913 0.0340 6.5e-08 0.077 0.074 0.068 NA 0.082 2.0e-08 3.9e-08 1.2e-07 NA 6.3e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bipolar Disorder (2018) 0.6 0.9 6.2 -0.6 -0.5 1.5 -1.4 -0.4 -0.2 -0.2 -2.1 -0.9 -0.4 -0.6 2.5 0.7 -0.7 0.3 0.4 0.5 0.7 -0.1 0.1 0.3 -0.5
Bipolar Disorder or Schizophrenia 0.7 1.6 6.1 -1.7 -2.5 -0.7 0.5 -1.0 0.7 -1.7 -1.9 -0.5 -1.0 -1.0 0.7 0.4 -0.9 -2.0 -0.9 -0.6 -1.4 1.6 -1.6 -0.1 -1.2
Depressed Affect (Nagel 2018) 0.1 0.2 1.2 0.7 0.3 -0.1 0.8 0.5 0.1 -0.1 1.1 0.7 0.0 0.6 -0.4 -0.5 0.7 -0.2 -0.2 0.5 -0.2 0.5 -0.1 0.5 0.4
Depression (Nagel 2018) 0.9 1.3 2.6 1.5 0.5 1.5 0.7 1.6 0.7 0.9 1.1 1.2 0.6 1.2 0.1 1.5 -1.0 1.1 0.7 1.4 1.2 0.0 1.4 1.6 1.5
Intelligence (Savage-Jansen 2018) 0.7 2.2 4.0 1.9 1.1 1.6 0.0 1.5 1.4 1.5 1.5 1.7 1.9 2.0 0.4 1.7 -1.9 1.0 -0.7 1.7 1.3 0.6 1.7 1.9 1.4
Neuroticism (Nagel 2018) 0.1 0.2 1.0 0.5 0.4 -0.2 -0.0 -0.1 -0.2 -0.4 0.7 0.6 -0.0 0.3 -0.3 -0.6 1.0 -0.1 0.5 0.5 -0.1 -0.1 -0.3 -0.1 -0.4
Schizophrenia (2018) 1.2 2.5 8.0 -1.8 -2.7 -2.1 1.7 -0.9 1.1 -2.1 -0.8 0.1 -0.9 -0.7 -1.1 0.0 -0.6 -2.8 -1.6 -1.2 -2.4 2.2 -2.1 -0.4 -1.2
Schizophrenia vs Biploar Disorder 1.0 1.4 4.3 -0.8 -1.1 -1.8 1.5 -0.7 0.7 -1.0 0.3 0.3 -0.4 -0.4 -1.3 -0.5 -0.3 -1.9 -1.1 -1.1 -2.1 1.8 -1.8 -0.9 -0.4
Worry (Nagel 2018) 0.1 0.2 0.5 0.5 0.6 0.1 -0.1 0.2 0.3 -0.1 0.5 0.4 0.3 0.5 -0.1 0.6 0.7 0.1 0.7 0.7 0.0 -0.0 0.2 0.3 0.1
Alzheimer’s Disease (in mother) 0.5 0.6 1.4 -0.9 -1.0 -0.7 -0.9 -1.0 -0.9 -0.7 -0.3 -0.7 -1.0 -0.6 -1.0 0.3 0.9 0.2 0.9 -0.6 0.4 -1.2 0.1 -0.7 -0.6
Alzheimer’s Disease (in father) 0.4 0.4 1.8 0.3 0.4 -0.6 0.4 0.4 -0.0 -0.2 1.3 1.2 -0.3 0.4 -1.1 -0.6 0.8 -0.7 -1.1 -0.4 -0.4 0.7 0.0 0.4 0.5
Alzheimer’s Disease (including proxy) 0.4 0.6 4.1 -0.5 -1.0 -1.2 -0.5 -0.4 -0.6 -0.9 1.1 0.4 -0.8 0.2 -2.0 -0.2 1.3 -0.5 -0.4 -0.6 0.0 -0.7 0.2 -0.3 -0.3
Crohns Disease (2017) 1.1 2.5 5.8 -1.7 -1.2 -1.2 -0.3 -1.5 -1.8 -1.6 -0.7 -1.4 -2.4 -2.2 -0.1 -2.0 1.2 -1.7 0.3 -2.2 -1.9 -0.5 -2.2 -1.8 -1.6
Irritable Bowel Disease (IBD) 1.6 3.8 9.2 -1.9 -1.1 -0.3 -2.2 -2.3 -3.0 -1.4 -1.3 -2.0 -2.7 -2.7 0.3 -2.0 1.6 0.2 2.6 -1.8 -0.6 -2.7 -1.4 -2.1 -2.2
Ulcerative Colitis (UC) 2.2 4.0 13.4 -1.7 -0.8 0.2 -2.9 -2.2 -3.4 -0.8 -1.0 -2.0 -2.4 -2.4 0.1 -1.6 1.8 1.5 3.7 -1.1 0.4 -3.6 -0.5 -1.9 -1.9
Major Depression (MDD) 0.3 0.4 1.4 -0.8 -1.2 0.6 0.2 0.4 -0.9 -0.0 -0.8 -1.0 -0.6 -0.6 0.5 -0.6 0.1 0.2 1.0 -0.0 0.4 -1.1 0.1 0.3 0.2
Reaction Time 0.3 0.6 2.6 0.5 1.3 1.1 -0.2 0.9 -0.3 1.1 -0.5 0.5 0.2 0.2 1.0 0.3 -0.9 1.0 -0.2 0.6 1.6 -1.1 0.9 0.0 0.1
Verbal and Numeric Reasoning (VNR) 1.3 3.2 6.0 2.0 1.0 1.8 0.2 1.8 1.3 2.2 1.6 1.9 2.4 2.1 0.0 2.3 -2.4 2.2 0.2 2.1 1.6 0.1 2.3 2.2 1.8
Breast Cancer 0.4 1.0 4.9 0.3 -0.7 -0.5 1.2 0.6 1.6 0.5 -0.9 1.1 0.7 0.7 0.1 0.9 -1.5 -1.3 -1.3 0.6 -0.8 2.2 -0.5 0.9 0.6
Ovarian Cancer 0.2 0.2 1.3 0.0 0.5 -0.2 -1.0 -0.5 0.4 0.1 -0.5 0.0 0.3 -0.1 0.1 -0.3 -1.2 0.3 -1.0 0.3 -0.0 0.0 -0.1 -0.0 -0.5
Prostate Cancer 2.6 3.6 8.0 -2.4 -2.0 -1.3 -1.8 -2.8 -1.4 -1.9 -2.6 -1.6 -2.0 -2.2 0.0 -2.3 1.5 -1.2 0.9 -1.9 -1.4 -0.4 -2.2 -2.7 -2.4
Age at First Birth 0.3 0.4 2.0 0.2 1.2 0.3 -0.4 0.2 -0.9 0.4 0.4 -0.0 0.2 -0.0 -0.5 -0.6 0.0 1.0 0.7 0.2 0.7 -1.4 0.7 -0.4 0.3
Bipolar Disorder (2011) 2.2 2.1 6.1 1.2 1.2 2.4 -0.5 1.0 1.4 1.2 -1.2 0.6 1.3 1.2 2.5 2.1 -1.5 1.3 -0.4 2.1 2.0 0.5 1.4 1.4 1.2
Body Mass Index (BMI) (2010) 1.4 2.0 5.7 -1.3 -0.4 -0.9 0.4 -1.3 -0.4 -1.9 -1.7 -1.1 -1.6 -1.4 0.1 -1.4 0.6 -2.4 -1.4 -1.8 -2.1 1.4 -2.0 -1.0 -1.3
Coronary Artery Disease (CAD) 1.9 2.2 8.3 -0.3 -0.6 -2.1 2.3 -0.1 0.5 -0.7 2.9 1.7 -0.4 0.2 -2.4 -0.6 -0.3 -2.5 -2.1 -1.2 -2.1 1.5 -1.1 -0.2 0.6
Crohns Disease (2012) 0.5 0.7 2.2 -0.8 -0.1 -0.3 -0.4 -0.8 -1.5 -0.9 -0.6 -0.7 -1.4 -1.5 0.4 -0.6 -0.0 -0.7 -0.2 -1.4 -0.9 -0.4 -1.0 -1.1 -0.8
Mean Putamen Volume 1.1 1.2 3.4 -1.8 -1.1 -0.0 -1.7 -1.6 -0.2 -0.8 -1.5 -1.9 -0.5 -1.2 0.4 -1.6 -0.0 -1.0 1.1 -1.0 -1.1 0.1 -0.7 -0.1 -1.0
Fasting Glucose 0.8 0.9 4.3 1.0 1.2 1.3 -0.4 0.7 0.7 0.5 -1.6 -0.5 0.4 0.6 2.1 1.4 -0.3 0.7 0.1 0.8 1.3 0.2 1.1 1.2 0.4
HbA1C 1.0 1.1 2.2 -1.0 -1.1 -1.5 0.5 -0.9 -1.0 -0.9 -0.9 -0.3 -1.3 -1.0 -1.0 -1.4 0.3 -1.1 -0.1 -1.3 -1.3 0.1 -1.5 -1.3 -1.2
HDL Cholesterol 0.3 0.5 2.3 0.1 -0.5 -0.7 0.8 0.1 0.6 0.1 1.5 1.1 0.2 0.5 -0.4 -1.0 0.1 -0.8 -1.2 -0.2 -0.7 1.1 -0.5 -0.2 0.6
LDL Cholesterol 0.4 0.7 3.0 0.6 -0.5 -0.9 1.3 0.1 0.1 -0.4 1.4 1.7 -0.1 0.4 -1.4 0.3 0.7 -0.8 -1.0 -0.1 -1.2 0.8 -0.8 -0.1 0.1
Lupus 1.9 2.9 9.6 -2.2 -1.5 -0.6 0.8 -1.0 0.5 -1.6 -3.1 -2.3 -1.5 -1.7 1.2 -1.1 1.0 -2.9 -1.3 -1.9 -1.9 1.7 -2.1 -0.9 -1.6
Neuroticism (2016) 7.6 11.0 30.4 4.4 4.8 2.7 -0.0 3.5 0.6 3.8 5.5 3.0 3.2 3.8 -0.6 1.6 -0.7 4.2 0.1 3.0 4.1 -2.1 5.1 3.2 3.7
Primary Biliary Cirrhosis 6.5 9.3 16.3 -4.0 -3.6 -3.5 -0.5 -3.6 -3.1 -3.5 -1.7 -2.5 -3.6 -3.8 -2.0 -3.7 2.1 -2.5 0.4 -3.4 -3.5 -0.7 -3.8 -3.5 -3.5
Rheumatoid Arthritis 0.6 0.8 2.3 1.5 1.3 1.5 -0.4 0.8 0.2 1.0 0.3 0.1 0.5 0.6 1.5 0.9 0.4 1.0 -0.4 0.6 1.1 -0.2 1.1 0.5 0.6
Schizophrenia (2014) 1.5 3.4 11.8 -2.5 -3.4 -2.2 0.8 -1.7 0.7 -2.4 -1.3 -0.4 -1.3 -1.3 -0.8 -0.4 -0.7 -3.1 -1.7 -1.4 -2.7 2.0 -2.6 -1.0 -1.7
Triglycerides 6.8 11.2 24.6 4.1 3.8 4.0 -0.5 3.8 0.9 4.2 1.6 2.1 3.4 3.4 1.7 3.5 -2.1 5.0 0.6 4.0 4.7 -1.6 4.9 4.0 3.3
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.7 0.8 -0.3 1.2 1.1 1.3 1.3 1.1 -1.1 0.5 1.5 1.1 1.9 1.5 -0.3 -0.4 -1.3 1.5 0.3 1.8 0.4 1.3 0.8
Ulcerative Colitis 2.2 3.2 13.8 0.5 0.7 2.3 -3.7 -0.9 -1.8 1.1 -0.5 -0.4 -0.4 -0.6 1.7 0.3 0.2 3.4 3.0 0.8 2.4 -3.3 1.6 -0.1 -0.5
Blood Eosinophil Count 0.1 1.0 3.3 1.1 1.4 1.8 -1.4 0.3 1.2 0.9 -0.5 0.4 1.0 0.7 1.7 1.6 -1.0 0.7 0.2 0.7 0.8 0.1 0.9 1.1 0.3
Blood Platelet Count 0.2 2.0 11.2 1.6 2.0 0.6 1.2 1.9 0.3 0.4 1.0 1.7 0.8 1.4 -0.3 3.3 1.2 1.2 1.1 0.6 1.6 -0.4 1.9 0.6 1.7
Blood Red Count 0.7 6.5 33.4 -1.4 -1.1 -0.1 -3.8 -1.8 -3.4 -0.5 -1.4 -2.4 -1.6 -1.9 -0.8 0.1 3.0 3.4 5.8 -0.6 2.4 -5.3 1.2 -1.8 -1.7
Blood White Count 0.1 0.5 1.9 -0.2 -0.5 1.0 -1.4 -0.1 0.0 -0.7 -1.0 -0.3 -0.4 -0.0 0.6 1.2 0.9 0.1 0.8 0.4 0.6 -0.9 0.5 0.7 -0.6
Heel T-Score 0.0 0.3 1.6 -0.5 0.0 -0.5 -0.1 -0.4 -0.8 -0.6 -0.1 0.3 -0.5 -0.2 -1.3 0.4 -0.0 0.5 0.6 -0.2 0.2 -1.2 0.4 -0.1 -0.4
BMI 0.5 2.7 4.9 2.2 1.0 1.9 0.2 1.6 2.0 1.8 1.2 1.4 2.1 1.8 1.5 1.9 -1.8 0.4 -1.8 1.8 1.1 1.3 1.5 2.0 2.1
Height 0.4 7.5 28.6 -1.6 -0.3 1.1 -3.9 -2.4 -4.0 -1.2 -2.6 -3.8 -2.4 -2.7 1.3 -1.5 3.4 2.0 5.3 -1.5 1.4 -4.7 -0.1 -3.0 -2.2
Waist Hip Ratio (WHR) 0.7 3.2 8.3 1.3 0.4 -1.4 2.6 1.4 2.2 0.8 2.3 2.5 1.7 2.1 -2.2 2.0 -1.8 -0.8 -2.2 1.2 -0.8 2.9 0.2 1.8 1.3
Systolic Blood Pressure 0.3 1.3 10.0 -1.2 -0.6 -1.8 0.1 -0.9 0.7 -1.1 0.2 -0.5 -0.6 -0.1 -1.0 -3.2 -1.1 -1.5 -0.5 -1.7 -1.1 0.5 -0.6 -0.4 -0.6
Smoking Status 0.7 1.7 5.8 -0.5 -2.4 -1.8 1.3 -0.4 0.9 -0.5 1.6 1.5 0.3 0.4 -1.8 -0.5 -0.5 -2.1 -1.7 -0.3 -2.1 1.6 -1.5 0.1 -0.6
Allergy or Eczema 0.7 1.9 5.2 1.2 0.7 0.3 1.8 1.6 1.4 1.4 1.5 2.3 1.5 1.6 -0.4 2.1 -1.1 0.9 -0.5 1.3 0.7 1.0 1.2 1.4 1.8
Cardiovascular Disease 0.6 2.0 6.7 1.0 1.3 -0.1 0.8 1.4 2.6 0.5 1.5 1.8 1.7 2.4 -0.9 0.5 -0.2 -0.5 -1.7 0.6 0.4 2.1 1.4 1.6 2.1
Hypothyroidism (self reported) 0.7 1.5 3.5 1.3 1.9 1.2 1.0 1.4 1.3 1.6 -0.5 0.2 1.2 0.9 1.8 0.5 -1.0 1.6 -0.2 1.4 1.4 0.9 1.4 1.4 1.4
Respiratory disease 0.3 0.6 4.8 0.8 0.9 -0.1 -0.6 0.1 0.6 0.1 0.8 2.2 0.2 0.7 -0.5 1.2 -0.4 0.8 -0.8 0.7 0.7 -0.1 0.3 -0.5 0.1
Type 2 Diabetes (T2D) (2018) 0.1 0.3 1.1 -0.0 0.6 -0.2 -0.7 -0.3 -0.3 -0.7 0.7 0.2 -0.8 -0.3 -0.1 -0.3 1.1 -0.6 0.3 -1.0 -0.3 -0.5 -0.1 -0.5 0.0
Lung FEV1/FVC ratio 0.2 1.2 4.6 -1.0 -1.0 -0.6 0.8 -0.2 -1.2 -1.2 1.2 -2.2 -0.8 -1.1 -0.9 -0.3 1.7 -1.5 1.4 -1.3 -1.7 -0.0 -0.8 0.7 0.1
Lung FVC 0.5 2.4 7.6 -2.1 -1.4 -0.5 1.1 -0.9 -1.8 -1.5 -2.8 -2.0 -1.6 -2.5 0.1 -1.1 -0.5 -0.4 2.7 -1.4 -0.6 -1.7 -1.0 -0.6 -1.4
Neuroticism 1.5 3.6 10.4 -1.7 -0.6 -1.7 -0.4 -1.8 -2.5 -2.4 0.5 -0.9 -2.5 -2.0 -1.3 -2.2 3.2 -1.9 0.8 -2.3 -2.0 -1.2 -2.1 -2.3 -1.9
Chronotype (morning person) 0.5 1.1 3.3 1.8 1.3 1.3 0.5 1.4 0.2 1.2 1.3 0.6 1.0 0.8 0.8 0.4 0.6 0.9 0.7 0.5 1.1 -0.2 1.4 1.2 1.5
Hair Pigment 0.1 2.9 8.9 -2.4 -0.8 1.1 -1.4 -1.1 -2.6 -0.9 -2.7 -3.0 -1.4 -2.3 1.9 -1.1 0.8 1.1 2.7 0.1 -0.0 -2.0 -1.0 -0.4 -1.8
Tanning 0.2 2.2 4.8 -1.7 -1.2 -1.9 1.2 -1.0 -1.9 -1.6 -0.2 -0.4 -2.1 -1.6 -1.8 -1.5 1.8 -1.6 0.8 -2.2 -1.5 -1.3 -1.3 -1.3 -1.1
Hand grip strength (left) 0.4 1.1 3.8 -1.1 -1.2 0.6 -0.3 -0.2 -1.4 -0.2 -1.8 -1.9 -1.3 -1.5 1.1 -0.9 1.1 0.1 2.0 -0.7 0.1 -0.9 -0.2 -0.4 -0.4
Number of treatments/medications taken 0.6 1.1 5.0 -0.5 -1.1 -0.8 0.3 -0.3 0.8 -1.4 0.9 0.5 -0.4 -0.1 -0.2 -1.2 -0.4 -2.2 -2.1 -1.2 -1.6 1.5 -1.1 0.1 0.0
Average weekly spirits intake 2.1 2.6 5.7 2.1 1.9 1.8 0.8 2.3 0.8 1.8 1.3 1.0 2.1 1.9 1.1 1.8 -0.1 1.5 -0.4 2.4 1.8 0.1 1.8 1.9 1.8
Sensitivity / hurt feelings 3.6 6.1 19.4 3.4 4.4 3.4 -1.6 2.3 0.2 2.6 2.1 2.0 1.9 2.3 1.9 1.5 0.1 3.5 1.3 2.2 3.2 -1.7 3.5 2.4 1.9
Frequency of depressed mood in last 2 weeks 2.7 3.8 7.5 2.7 1.8 2.7 -0.6 2.2 0.7 1.8 2.3 2.4 1.7 2.1 0.5 1.7 -1.0 2.3 0.2 2.2 2.5 -0.8 2.7 2.5 2.2
Hearing difficulty/problems: Yes 0.2 0.3 1.0 0.0 -0.3 0.6 -0.8 -0.4 -0.4 -0.3 0.3 -0.8 -0.1 -0.2 0.4 -0.7 -0.3 -0.7 -1.0 -0.7 -0.2 -0.5 -0.2 -0.2 -0.4
Relative age of first facial hair 0.1 0.3 0.8 -0.0 -0.5 0.2 -0.8 -0.6 -0.8 -0.6 0.7 -0.6 -0.7 -0.6 -0.4 0.2 -0.7 -0.2 0.2 -0.8 -0.2 -0.9 -0.0 -0.5 -0.4
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 4.6 2.2 1.6 1.4 0.7 1.5 1.5 1.5 1.4 1.2 1.7 1.7 1.1 1.0 -0.8 0.7 -1.9 1.6 0.7 1.1 1.0 1.4 1.4
Ever used hormone-replacement therapy (HRT) 1.2 1.6 5.9 1.5 0.6 0.8 -0.1 1.0 2.2 0.8 0.7 1.4 1.3 1.6 1.1 0.9 -0.9 -0.8 -2.4 0.4 -0.2 2.0 0.6 1.8 0.8
Ever had hysterectomy (womb removed) 1.1 1.3 3.0 -1.3 -1.5 -0.5 -0.3 -1.3 -0.8 -1.7 -1.7 -1.2 -1.6 -1.4 0.7 -0.1 0.3 -0.8 0.3 -1.1 -1.1 -0.2 -1.5 -1.2 -1.4
Systolic blood pressure, automated reading 3.3 9.7 19.2 -4.2 -3.4 -2.9 0.2 -3.2 -0.3 -3.9 -3.9 -3.6 -3.3 -3.0 0.4 -3.6 0.4 -4.4 -1.0 -4.1 -3.6 1.9 -4.1 -3.0 -3.2
Eye problems/disorders: Diabetes related eye disease 0.2 0.3 1.2 -0.1 0.2 0.3 -0.8 -0.4 -0.3 -0.7 0.2 0.4 -0.5 -0.5 0.8 -0.2 0.6 -0.5 -0.4 -0.4 -0.0 -0.3 -0.5 -1.1 -0.7
Angina 0.5 0.7 1.8 -0.5 -0.7 -1.2 1.1 -0.5 -0.2 -0.7 -0.1 0.4 -0.5 -0.7 -0.4 -0.9 0.8 -1.2 -0.8 -0.8 -1.4 0.9 -1.2 -1.0 -0.8
Medication for hormone replacement therapy 0.5 0.6 2.0 0.6 -0.2 0.9 -0.7 0.2 1.3 0.6 -1.3 0.6 0.6 0.5 1.4 0.6 -1.2 0.3 -0.7 0.6 0.4 0.8 0.3 0.6 -0.1
Vitamin and mineral supplements 1.6 2.2 6.8 1.9 1.8 2.3 -1.6 1.0 -0.7 1.6 -0.1 0.5 0.9 0.6 1.5 1.1 -0.5 2.6 1.2 1.5 2.3 -1.9 2.1 0.9 0.6
Supplements: Zinc 0.9 1.0 4.1 -0.9 -0.8 -1.7 0.9 -0.6 1.2 -1.1 -0.0 0.3 -0.2 0.2 -1.1 -0.4 0.3 -1.6 -0.9 -0.9 -1.7 2.0 -1.2 -0.3 -0.4
Medication: Co-codamol 1.8 2.1 7.2 -0.7 -0.7 0.5 -2.7 -1.8 -1.8 -1.2 -1.7 -1.1 -2.0 -1.7 1.0 -1.3 1.5 -0.2 1.0 -1.4 -0.7 -1.5 -1.1 -1.5 -2.3
Medication: Metformin 0.3 0.4 1.8 0.1 -0.1 0.2 1.1 0.5 1.0 -0.6 -1.0 0.4 -0.1 0.1 1.1 0.5 -0.1 -1.0 -0.3 -0.6 -0.5 1.4 -0.5 -0.1 0.3
Diabetes (father) 2.1 2.6 7.0 -1.9 -2.1 -1.9 -0.0 -1.9 -0.5 -1.6 -0.6 -1.1 -1.9 -1.6 -0.5 -1.7 0.7 -2.5 -0.4 -2.5 -2.6 0.4 -2.1 -1.0 -1.6
Diabetes (mother) 0.5 0.6 1.9 0.1 -1.2 0.3 0.4 0.8 1.3 -0.2 -0.2 0.1 0.7 0.9 -0.0 0.9 -1.4 -0.5 -1.0 0.6 -0.1 1.1 0.3 1.3 0.6
Severe depression (siblings) 0.6 0.7 2.1 -1.0 -1.3 -0.5 -0.4 -1.1 -0.3 -1.0 -1.0 -0.8 -0.8 -0.7 -0.1 -1.4 0.5 -0.3 -0.2 -1.2 -0.6 -0.4 -0.6 -0.6 -1.4
Pack years adult smoking proportion 0.9 1.4 7.2 -1.2 -2.7 -1.7 0.5 -0.8 1.1 -0.8 -1.8 0.0 0.2 -0.1 -0.7 0.2 -0.9 -1.4 -0.7 -0.1 -1.4 1.9 -1.5 -0.6 -1.1
Impedance of leg (right) 5.0 24.4 61.5 7.0 6.0 2.7 1.2 5.6 2.8 5.9 7.8 6.2 5.5 6.5 -1.5 3.5 -1.1 4.9 -1.0 5.5 5.0 -0.4 6.5 5.1 5.7
Leg fat-free mass (left) 1.5 8.0 25.3 -3.5 -4.1 -0.6 -1.8 -3.2 -1.6 -2.9 -5.0 -4.0 -2.9 -3.7 2.3 -1.5 0.3 -2.5 1.0 -2.9 -2.5 0.4 -3.4 -2.6 -3.2
Trunk fat percentage 0.3 1.0 5.5 1.1 -0.3 1.5 -0.6 0.5 1.3 0.3 -0.3 -0.2 0.6 0.8 2.3 2.2 -0.4 -0.4 -1.3 0.4 0.4 1.5 0.3 0.5 0.6
Hand grip strength (right) 0.5 1.4 4.2 -1.1 -1.0 0.1 -0.5 -0.6 -2.0 -0.2 -1.7 -2.0 -1.5 -1.8 0.9 -1.3 1.1 0.5 1.8 -1.0 0.1 -1.3 -0.4 -1.1 -0.9
Townsend deprivation index at recruitment 0.5 0.7 4.0 -1.0 -1.6 -0.0 -2.0 -1.3 -0.5 -0.1 -0.5 -0.6 -0.6 -0.7 0.0 -1.2 -0.4 -0.1 0.1 -0.8 -0.1 -0.9 -0.4 -0.5 -1.1
Current tobacco smoking 2.2 3.6 10.9 -2.2 -3.1 -1.9 1.4 -1.6 0.7 -1.8 -3.2 -0.9 -0.9 -1.4 0.3 -0.1 -0.5 -2.8 -1.1 -0.8 -2.6 2.6 -3.3 -1.4 -2.0
Average weekly fortified wine intake 3.5 4.1 10.5 2.3 3.2 1.5 -0.3 2.4 0.2 2.4 2.6 1.7 1.7 2.0 -0.1 1.8 -0.1 2.4 0.6 1.6 2.9 -1.3 3.2 1.4 2.8
Maternal smoking around birth 0.8 1.2 4.2 1.2 0.7 1.2 0.3 1.5 1.0 0.4 0.7 2.1 0.8 1.2 0.4 1.7 -0.9 0.3 -1.1 1.2 1.1 0.3 1.2 1.3 1.6
Fed-up feelings 1.8 3.3 9.0 2.8 1.7 1.5 0.7 2.4 0.2 2.1 3.0 2.3 1.7 2.4 -0.3 -0.2 0.6 1.7 -0.0 1.9 1.8 -0.9 2.4 2.2 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 4.1 1.1 0.8 1.3 -0.5 1.0 0.1 0.8 2.0 1.2 0.2 0.9 -0.2 0.4 -0.3 0.8 0.2 0.8 1.0 -0.6 1.2 1.3 1.3
Relative age voice broke 0.4 0.6 2.8 -0.1 -0.9 -1.1 1.7 -0.1 -0.6 -0.4 1.5 0.1 -0.2 -0.2 -1.6 0.3 -0.5 -0.7 -0.7 -0.2 -0.9 0.4 -0.7 -0.4 -0.0
Taking other prescription medications 0.4 0.6 2.3 1.0 1.5 1.0 0.4 1.0 0.5 0.2 0.5 1.1 0.6 0.7 1.2 0.7 -0.0 0.0 -1.5 0.2 0.4 0.6 0.5 0.5 0.6
Age when periods started (menarche) 1.6 3.8 10.2 2.4 1.2 2.2 -0.7 1.8 0.7 3.1 0.6 0.5 2.4 2.0 1.5 2.5 -0.6 2.6 0.7 2.9 3.2 -1.1 2.7 1.2 1.4
Bilateral oophorectomy (both ovaries removed) 1.3 1.6 5.7 -1.1 -1.7 0.3 -0.9 -0.7 -2.4 -1.2 -0.5 -1.5 -1.7 -1.7 0.1 -0.9 1.3 0.2 1.8 -1.1 -0.4 -1.9 -0.7 -1.2 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 9.6 21.7 45.2 -6.7 -5.4 -4.0 -0.9 -5.4 -2.3 -6.2 -5.7 -5.9 -5.3 -5.8 -1.0 -3.1 1.4 -4.9 0.3 -5.0 -5.2 0.6 -6.4 -5.0 -5.3
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 7.0 -1.8 -2.6 -1.2 -0.8 -1.5 -0.8 -1.2 -0.5 -1.5 -1.1 -1.5 -1.1 -1.3 1.0 -1.4 0.6 -1.2 -1.2 -0.1 -1.6 -1.4 -1.1
Qualifications: CSEs or equivalent 0.6 0.8 3.8 1.1 0.3 1.4 0.0 0.8 0.7 0.6 0.4 0.6 0.7 1.0 1.1 2.0 -0.7 0.2 0.6 0.8 0.5 0.4 0.9 1.7 0.9
Serious illness, injury or assault to yourself 2.1 2.6 5.0 1.9 0.2 1.4 1.0 2.0 1.8 1.7 2.0 1.7 2.1 2.1 0.6 2.1 -1.0 0.2 -1.2 2.0 1.2 1.1 1.7 2.2 1.6
High blood pressure 3.5 9.7 21.3 -4.5 -4.3 -3.7 -0.2 -3.3 0.0 -4.6 -3.2 -2.6 -2.9 -2.8 -1.2 -2.8 0.5 -4.5 -1.0 -3.8 -3.8 2.1 -3.9 -2.8 -2.9
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.7 -0.2 -0.2 -0.8 1.1 0.1 0.4 -0.3 1.0 0.9 -0.2 0.2 -1.3 0.9 -0.1 -0.4 -0.4 -0.4 -0.8 0.7 -0.4 -0.3 0.2
Multivitamins +/- minerals 0.6 0.8 2.3 -1.5 -1.2 -1.3 -0.2 -1.2 0.1 -0.8 -0.8 -0.6 -0.9 -1.0 -0.4 -1.0 -0.1 -0.9 0.3 -1.0 -0.9 0.5 -1.2 -1.0 -1.0
Stomach or abdominal pain in last month 1.6 2.0 3.8 1.6 0.1 0.7 -1.1 1.0 0.8 1.8 1.9 1.9 1.7 1.5 -0.1 1.6 -1.5 1.8 -1.0 1.9 1.5 -0.3 1.8 1.2 1.3
Supplements: Glucosamine 1.1 1.5 3.8 1.1 0.1 0.3 1.7 1.3 1.9 1.0 0.9 1.9 1.4 1.5 0.3 1.2 -0.9 -0.7 -1.4 0.2 -0.3 1.9 0.5 1.2 1.6
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 3.7 1.2 1.0 1.6 -0.9 0.8 1.6 1.1 -0.2 1.0 1.5 0.9 1.9 1.9 -1.0 0.6 -0.1 0.8 0.9 0.7 1.2 1.2 0.6
Medication: Atenolol 0.6 0.8 3.8 -0.5 -0.5 -0.3 0.7 -0.2 1.1 -0.7 -1.8 0.0 -0.4 -0.4 1.0 -0.3 -0.9 -1.1 -1.0 -0.2 -0.9 2.0 -0.9 0.0 -0.3
Medication: Levothyroxine sodium 5.5 9.2 16.6 4.1 3.2 2.7 1.3 3.8 2.0 4.0 3.6 3.5 3.6 3.7 1.0 1.9 -1.7 2.9 -1.2 3.6 2.9 0.6 3.8 3.8 3.6
Sitting height 1.2 8.3 14.7 -3.5 -3.2 -3.1 -0.9 -3.4 -2.7 -3.2 -1.9 -2.1 -3.6 -3.4 -1.6 -3.1 3.4 -2.2 1.4 -3.8 -3.2 -0.3 -3.5 -3.6 -2.7
Chronic bronchitis/emphysema (father) 0.8 0.9 3.0 1.1 0.6 1.4 -0.6 0.8 1.1 1.3 -0.5 0.4 1.3 1.1 1.7 1.4 -0.5 0.8 -0.1 1.1 1.2 0.4 0.7 0.6 0.3
High blood pressure (mother) 2.1 3.0 9.1 -2.0 -1.8 -1.0 -2.0 -2.3 -1.1 -2.0 -3.0 -1.7 -1.6 -2.1 0.6 -2.1 0.1 -0.8 1.3 -2.0 -1.0 -0.7 -1.5 -1.7 -2.3
Body mass index (BMI) 2.0 8.5 22.4 -3.4 -4.2 -1.3 0.1 -2.7 0.1 -3.5 -4.7 -3.2 -2.6 -3.1 2.1 -0.7 0.2 -4.3 -1.5 -2.9 -3.6 3.0 -4.3 -2.4 -2.7
Impedance of leg (left) 5.8 28.2 66.7 7.3 6.5 3.0 1.6 6.2 3.0 6.3 8.2 6.4 5.8 6.9 -1.5 4.2 -1.2 5.4 -0.8 5.9 5.6 -0.6 7.0 5.3 6.3
Leg predicted mass (left) 1.5 7.9 25.7 -3.5 -4.0 -0.5 -1.8 -3.1 -1.6 -2.8 -5.1 -4.0 -2.9 -3.7 2.3 -1.5 0.2 -2.4 1.0 -2.9 -2.4 0.3 -3.3 -2.6 -3.2
Trunk fat mass 0.2 1.0 6.4 0.0 -1.2 1.1 -0.8 -0.3 0.7 -0.5 -1.5 -1.2 -0.2 -0.3 2.5 1.4 -0.2 -1.1 -0.9 -0.5 -0.4 1.5 -0.7 -0.3 -0.3
Waist circumference 0.2 0.9 5.0 0.4 -0.8 0.7 0.4 0.1 1.3 -0.2 -0.4 -0.1 0.4 0.3 1.6 1.2 -0.8 -1.4 -1.7 -0.1 -0.9 2.2 -0.7 0.5 0.2
Number of incorrect matches in round 0.3 0.5 4.5 0.4 2.1 -0.2 0.6 0.8 0.5 -0.0 0.5 0.3 0.4 0.6 -0.3 -0.2 -1.0 0.5 -0.8 0.5 0.5 0.1 0.6 0.8 0.6
Past tobacco smoking 1.1 1.9 7.5 1.1 1.8 1.4 -1.9 0.4 -1.9 1.1 0.2 -0.4 -0.1 -0.2 0.3 -0.1 1.1 2.5 1.9 0.7 2.1 -2.7 1.8 -0.3 0.5
Alcohol usually taken with meals 1.2 1.9 3.8 -2.0 -0.9 -1.8 0.2 -1.6 -0.7 -1.7 -0.9 -1.5 -1.0 -1.5 -1.5 -0.7 1.1 -1.4 0.3 -1.8 -1.7 0.1 -1.7 -1.8 -1.6
Nervous feelings 5.5 10.3 28.5 4.5 4.7 2.6 0.2 3.5 1.2 3.4 5.3 4.4 3.5 3.8 -0.3 1.8 -0.8 3.2 -0.3 3.1 3.2 -1.1 4.3 3.3 3.6
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.8 1.5 1.0 1.6 -0.2 1.1 -0.3 1.0 1.2 1.1 0.7 0.9 0.5 1.1 0.2 1.6 0.5 1.7 1.3 -0.4 1.0 1.0 1.0
Hearing difficulty/problems with background noise 0.3 0.5 2.3 0.9 0.5 0.7 -0.5 0.5 0.3 0.6 1.5 0.8 1.0 0.8 0.1 0.3 -0.2 0.1 -0.9 0.5 0.7 -0.4 0.7 0.3 0.7
Hair/balding pattern: Pattern 2 1.1 1.4 4.0 0.9 -0.2 0.9 0.8 1.4 1.8 1.1 0.3 1.2 1.2 1.2 0.8 1.2 -1.4 -0.8 -1.5 0.9 -0.2 2.0 0.4 1.9 1.4
Had menopause 0.7 0.9 3.5 1.1 0.3 0.6 -0.6 0.3 1.9 0.6 -0.1 1.8 1.0 1.2 0.9 0.9 -1.3 -0.3 -1.1 0.4 0.2 1.7 0.5 0.8 0.4
Had other major operations 0.7 0.9 3.8 -0.4 -1.8 -0.6 0.9 0.2 1.2 -0.1 -0.5 0.3 0.4 0.4 0.2 1.2 -1.1 -1.5 -1.4 0.1 -0.9 2.0 -0.6 0.5 0.2
Forced vital capacity (FVC) 0.4 1.4 8.4 0.8 0.4 1.3 -0.5 0.6 -1.5 1.4 0.5 0.4 0.5 -0.0 0.5 0.2 0.6 1.7 2.9 0.3 1.5 -2.4 1.5 0.7 0.5
Heel bone mineral density (BMD) T-score, automated (right) 8.4 19.3 40.6 -6.4 -5.5 -3.6 0.1 -4.8 -2.0 -5.8 -5.6 -5.3 -5.0 -5.4 -0.5 -2.6 0.8 -5.0 -0.7 -4.7 -5.2 1.4 -6.3 -4.3 -5.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.9 0.3 0.9 0.8 0.9 0.9 -0.2 -0.1 0.6 0.2 -0.1 0.1 0.6 0.2 0.3 0.2 0.1 -0.2 0.2 -0.2 0.5 0.8 0.9
Qualifications: None of the above 1.1 2.3 8.8 1.2 0.6 0.4 0.5 1.0 2.5 0.5 1.2 2.6 1.3 1.5 0.9 0.9 -1.5 -1.7 -2.9 0.5 -0.9 3.0 -0.1 1.5 1.2
Financial difficulties in last 2 years 0.6 0.8 1.5 -1.1 -0.9 -0.5 -0.5 -0.9 -1.0 -1.2 -0.0 -0.8 -1.2 -1.0 -0.4 -1.1 1.0 -1.0 0.5 -1.2 -1.2 -0.3 -1.2 -0.8 -1.0
Mouth/teeth dental problems 0.7 1.1 4.9 1.0 1.0 1.1 -1.3 0.3 -1.0 1.1 0.5 0.0 0.5 0.2 0.2 -0.2 0.6 1.5 1.6 0.8 1.6 -2.2 1.3 0.1 -0.1
Heart attack 0.0 0.1 0.5 0.2 -0.2 -0.1 0.0 0.1 -0.4 0.2 0.1 0.2 -0.1 -0.1 0.3 -0.0 0.7 0.2 0.2 -0.1 0.0 -0.4 -0.0 -0.4 -0.1
Allergy 0.3 0.8 2.5 1.1 0.9 1.2 -1.0 0.7 -0.2 1.0 0.4 -0.3 0.7 0.6 0.9 -0.4 -0.2 1.0 0.8 0.8 1.6 -1.1 1.5 0.9 0.7
Pain all over the body in last month 0.7 0.8 2.7 -0.5 -0.9 -0.3 -1.3 -1.2 -0.5 -0.7 -1.0 -1.4 -0.9 -1.1 0.6 0.1 0.9 0.1 1.6 -0.8 -0.4 -0.4 -0.7 -0.9 -0.8
Diabetes (self-reported) 0.3 0.4 2.3 -0.3 -0.3 -0.3 0.2 -0.2 0.5 -1.1 -0.3 0.3 -0.7 -0.4 0.3 -0.3 -0.4 -1.5 -0.7 -1.1 -0.9 0.9 -0.7 -0.3 -0.1
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 4.6 -0.1 0.2 -0.2 -0.4 -0.2 -1.9 0.0 -0.1 -0.3 -0.8 -0.8 -0.5 -1.2 0.5 1.4 0.9 0.1 0.6 -2.2 0.1 -1.2 -0.8
Medication: Ramipril 1.5 2.0 7.3 -2.1 -1.8 -0.4 0.3 -1.2 -0.3 -1.3 -2.7 -1.7 -0.9 -1.6 1.6 -1.5 -0.1 -1.5 0.6 -1.2 -1.5 0.9 -2.0 -1.1 -1.2
Medication: Simvastatin 0.7 1.0 3.0 -1.3 -0.9 -0.6 -0.2 -0.7 -0.4 -1.7 -0.8 -0.7 -1.4 -0.7 -0.0 -1.5 1.1 -1.7 -0.5 -1.4 -1.1 0.0 -1.0 -0.7 -1.1
Fluid intelligence score 1.6 3.4 7.4 1.9 1.5 2.0 0.1 2.0 0.9 2.4 1.2 1.8 2.1 1.9 0.4 2.1 -1.6 2.7 1.0 2.3 2.2 -0.4 2.6 2.4 1.9
Illnesses of siblings 0.3 0.4 2.3 0.3 0.6 -0.1 0.4 0.1 0.1 1.1 -0.6 0.5 0.5 0.0 -0.0 0.3 -0.2 1.4 0.9 1.5 0.6 -0.0 0.2 0.2 -0.0
Neuroticism score 3.5 7.3 31.0 3.5 3.7 2.2 -1.0 2.5 -1.0 2.9 5.6 3.1 2.0 2.5 -0.9 0.2 0.4 3.5 1.1 2.1 2.9 -3.0 3.8 2.4 2.5
Weight 0.8 4.1 11.5 -2.1 -3.0 -0.2 -1.1 -2.1 -0.6 -2.2 -3.4 -2.7 -1.9 -2.4 2.2 -0.6 0.4 -2.5 -0.2 -2.2 -2.1 1.3 -2.6 -1.9 -2.0
Impedance of arm (right) 3.7 17.4 45.9 6.0 5.5 3.2 -1.2 3.9 1.2 4.8 6.8 4.2 3.9 5.1 -1.1 3.2 -0.7 5.1 0.5 4.1 5.2 -2.8 6.3 3.8 4.2
Arm fat percentage (right) 0.7 2.6 7.4 -1.4 -2.3 -0.3 -0.5 -1.5 0.7 -2.0 -2.3 -1.8 -1.2 -1.2 1.7 0.6 -0.2 -2.7 -1.4 -1.5 -1.9 2.1 -2.2 -1.3 -1.4
Trunk fat-free mass 0.8 4.7 11.6 -2.9 -3.3 -1.0 -0.9 -2.4 -1.5 -2.2 -3.4 -2.9 -2.3 -3.0 1.1 -1.9 0.2 -2.0 0.7 -2.4 -2.1 0.3 -2.7 -2.1 -2.2
Hip circumference 0.8 3.4 7.8 -1.7 -2.8 0.2 -0.9 -1.8 -0.6 -2.0 -2.8 -2.3 -2.0 -2.1 2.4 -0.4 0.8 -2.6 -0.7 -2.1 -2.0 1.3 -2.4 -1.6 -1.6
Time employed in main current job 1.7 2.0 7.5 1.2 0.4 -0.8 0.1 0.6 1.2 1.2 2.7 2.4 1.8 1.6 -1.9 0.4 -2.4 0.3 -1.9 1.4 0.5 0.4 1.0 0.9 1.3
Alcohol intake versus 10 years previously 0.7 1.1 4.4 0.1 0.7 1.7 -1.4 -0.3 -1.3 -0.1 -0.6 -1.5 -0.4 -0.7 1.2 -0.1 0.6 1.4 2.1 -0.3 0.7 -1.8 0.5 0.4 -0.6
Father’s age at death 1.2 1.6 9.6 1.4 2.3 -0.0 0.2 1.1 -0.4 1.3 3.1 0.8 0.7 1.0 -1.1 -0.1 0.9 1.5 0.3 0.7 1.0 -1.4 1.7 1.1 1.1
Worrier / anxious feelings 6.8 12.9 30.5 5.0 4.6 3.6 -1.2 3.6 1.0 4.2 5.5 3.2 3.8 4.2 0.1 1.8 -0.7 4.6 0.7 3.3 4.2 -2.5 5.5 4.0 3.5
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 3.5 1.6 0.9 1.8 -0.5 1.4 0.0 0.6 1.5 1.0 0.5 0.9 1.1 0.6 -0.3 1.0 0.3 1.0 1.2 -0.5 1.5 1.9 1.3
Falls in the last year 0.2 0.3 1.1 -0.4 0.1 -0.6 -0.3 -0.4 -0.3 0.1 -0.1 0.3 -0.3 -0.5 -0.3 -1.1 0.1 -0.7 -0.7 -0.9 -0.6 0.3 -0.7 -0.9 -0.6
Hair/balding pattern: Pattern 3 0.5 0.7 4.7 0.7 2.2 0.2 1.1 0.3 1.1 0.1 0.8 0.5 0.9 0.5 1.1 -0.5 0.5 -0.5 -1.2 0.6 -0.2 1.2 -0.2 0.1 0.3
Number of live births 0.3 0.4 1.5 -0.4 -1.2 0.1 -1.0 -0.8 -0.5 0.0 -1.0 -1.0 -0.4 -0.7 1.1 -0.8 -0.1 0.5 0.4 -0.1 0.1 -0.1 -0.3 -0.0 -0.6
Forced expiratory volume in 1-second (FEV1) 1.0 3.2 11.0 1.8 1.4 2.5 -0.4 1.6 -1.9 2.1 1.4 0.1 0.9 0.3 0.9 0.5 0.7 2.5 3.3 0.9 2.3 -3.0 2.5 1.7 1.4
Pulse rate 2.2 3.6 9.0 2.0 2.4 1.7 1.9 3.0 1.3 1.8 1.6 1.7 1.8 2.3 0.8 2.3 0.0 0.7 -1.9 2.2 1.5 1.6 1.8 2.3 3.0
Happiness 0.6 0.7 3.3 -0.3 0.2 -1.4 0.7 -0.2 -0.3 -0.8 1.4 0.2 -0.5 -0.3 -1.8 -1.8 1.3 -0.5 0.0 -0.6 -1.2 0.4 -0.5 -0.4 0.2
Noisy workplace 0.2 0.3 1.4 -0.1 -1.1 1.0 -0.9 -0.4 -0.3 0.1 0.5 0.4 -0.0 -0.1 0.8 -1.2 -0.0 -0.7 -0.2 -0.3 -0.2 0.1 -0.2 0.3 0.2
Qualifications: A levels/AS levels or equivalent 1.1 2.4 6.4 1.6 1.1 0.6 1.9 2.0 0.4 2.2 1.7 1.5 1.8 1.4 -0.9 1.1 -2.5 2.1 -0.3 2.2 1.6 -0.2 1.6 1.1 1.7
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 6.2 1.5 0.5 0.9 -0.2 1.1 0.4 1.5 2.5 1.4 1.5 1.4 -0.3 0.7 -0.2 1.2 -0.1 1.4 0.9 -0.2 1.4 1.4 1.2
Mouth/teeth dental problems: Dentures 2.0 3.3 6.6 -2.5 -1.7 -1.4 -0.6 -2.3 -1.2 -2.5 -2.1 -2.4 -2.2 -2.3 0.1 -1.2 0.9 -1.6 0.0 -2.0 -1.9 0.3 -2.6 -2.4 -2.1
Asthma 0.3 0.6 3.5 -0.5 -0.2 0.4 -1.2 -0.8 0.4 -0.6 -1.9 0.2 -0.8 -0.4 1.2 1.1 -0.7 -0.1 -0.2 -0.2 -0.2 0.2 -0.6 -0.7 -1.2
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.1 8.4 2.0 1.0 0.5 1.3 1.8 2.4 1.5 2.9 2.8 2.1 2.3 -0.6 1.7 -1.4 -0.2 -1.6 1.7 0.6 1.6 1.2 1.8 2.2
Medication: Cholesterol lowering 0.4 0.6 3.9 -0.5 0.5 -0.5 -0.1 -0.5 -0.5 -1.2 0.1 -0.9 -0.8 -0.6 -0.1 -0.8 2.0 -0.7 -0.1 -1.1 -0.6 -0.2 -0.5 -0.8 -0.4
Depression (self-reported) 1.1 1.3 3.8 1.3 0.8 1.9 -1.2 0.7 0.4 1.2 0.1 0.5 1.5 0.9 1.3 0.9 -0.1 1.8 0.5 1.4 1.5 -0.9 1.2 1.3 0.6
Medication: Lansoprazole 0.2 0.2 1.2 0.2 -0.7 0.2 -1.1 -0.3 -0.5 0.1 0.5 0.1 0.1 -0.1 -0.5 0.7 0.2 0.2 0.2 0.3 0.2 -0.5 0.3 0.3 -0.1
Prospective memory result 0.4 0.5 2.6 -0.4 0.0 -0.5 0.1 -0.8 -0.6 -0.8 0.2 0.1 -0.5 -0.6 -0.1 -0.6 1.6 -0.8 -0.0 -1.1 -1.1 0.3 -0.9 -0.6 -0.5
Lung cancer (father) 1.8 2.1 5.7 0.9 -0.1 -0.2 2.3 1.6 2.0 1.1 1.1 2.0 1.5 1.4 0.0 0.6 -1.9 -0.9 -2.4 1.0 0.0 2.3 0.2 1.0 1.8
Illnesses of mother 0.7 0.8 3.7 0.9 0.6 1.3 0.6 0.9 0.4 1.3 -0.5 -0.2 0.8 0.6 1.4 1.9 -0.1 1.3 0.4 1.4 1.1 0.1 0.6 0.4 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 14.3 1.1 1.5 2.1 -0.8 1.0 -2.4 1.3 0.8 -0.4 -0.1 -0.5 0.9 -0.3 0.9 2.3 3.8 0.2 2.0 -3.5 1.9 1.0 0.8
Pulse wave Arterial Stiffness index 2.8 3.3 9.9 -1.8 -2.1 -1.4 0.0 -1.3 -1.2 -2.5 0.6 -1.6 -2.0 -1.6 -1.2 -2.1 2.1 -3.2 -1.4 -2.6 -2.3 -0.5 -1.9 -1.7 -1.3
Impedance of arm (left) 3.4 15.8 37.5 5.6 5.3 3.3 -1.1 3.8 0.6 4.7 6.1 3.6 3.5 4.6 -0.7 3.0 -0.6 5.4 0.9 3.9 5.2 -3.3 6.1 3.4 3.8
Arm fat mass (right) 0.9 3.8 10.3 -1.8 -2.9 -0.5 -0.0 -1.7 0.5 -2.2 -3.1 -2.0 -1.5 -1.7 2.0 0.3 -0.1 -3.2 -1.5 -1.9 -2.4 2.5 -2.8 -1.6 -1.6
Trunk predicted mass 0.8 4.7 11.7 -2.9 -3.3 -1.0 -0.8 -2.3 -1.5 -2.2 -3.4 -2.8 -2.3 -2.9 1.1 -1.9 0.3 -2.0 0.7 -2.4 -2.1 0.3 -2.7 -2.1 -2.2
Standing height 0.5 4.7 14.0 2.6 2.4 2.3 -2.2 1.4 -1.4 2.5 2.5 0.7 1.3 1.4 0.5 0.6 0.5 3.7 2.6 1.4 3.1 -3.2 3.4 1.2 1.7
Length of working week for main job 1.0 1.1 4.1 -1.0 -1.7 -1.6 1.6 0.1 -0.2 -0.7 0.7 -0.7 -0.4 -0.3 -2.0 0.1 -0.0 -1.9 -1.2 -0.7 -1.2 0.5 -0.9 -0.9 0.3
Exposure to tobacco smoke at home 0.4 0.5 2.0 -0.9 -1.3 -0.5 -1.4 -1.0 0.5 -0.6 -0.5 -0.1 -0.3 -0.0 -0.8 -0.4 -1.3 -0.3 0.0 -0.5 -0.6 -0.3 -0.2 -0.1 -0.8
Breastfed as a baby 0.8 1.0 3.9 0.8 0.6 0.0 0.0 0.6 1.5 1.1 1.8 2.0 1.5 1.2 -0.4 -0.2 -1.0 -0.2 -1.4 0.5 0.1 0.7 0.6 0.7 1.0
Tense / ‘highly strung’ 3.8 6.2 15.6 3.6 3.8 2.3 -1.3 2.2 0.6 2.9 4.0 3.1 2.3 2.8 -0.1 1.4 -0.8 3.1 0.3 2.3 2.9 -1.4 3.5 2.2 2.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.9 0.5 0.7 2.0 -1.9 -0.1 -1.5 0.0 0.4 -0.2 -0.2 -0.6 1.6 -0.1 0.2 1.3 1.7 0.5 1.0 -1.7 0.5 0.3 -0.5
Hair/balding pattern: Pattern 4 0.0 0.1 0.5 0.1 -0.5 0.1 -0.2 0.2 -0.4 0.2 -0.1 -0.1 -0.1 0.2 -0.3 0.1 0.5 0.3 0.2 0.1 -0.0 -0.7 0.2 0.2 -0.0
Birth weight of first child 4.3 7.9 16.0 2.9 1.5 2.2 1.7 3.7 2.5 3.7 0.6 1.0 3.5 3.2 0.9 3.9 -3.5 3.1 -0.2 4.0 3.5 0.6 3.6 2.9 3.1
Peak expiratory flow (PEF) 2.5 5.7 12.9 3.1 2.6 2.9 -0.8 2.3 -0.2 3.4 2.4 1.8 2.5 1.9 0.8 1.9 -0.4 3.5 2.1 2.2 2.9 -1.8 3.6 2.9 2.4
Pulse wave reflection index 1.9 2.3 6.6 -1.9 -2.6 -1.6 0.8 -1.0 -0.7 -1.9 -0.2 -0.9 -1.3 -1.6 -1.0 -1.9 0.8 -2.4 -0.7 -2.2 -1.9 -0.1 -1.7 -1.6 -1.1
Ever highly irritable/argumentative for 2 days 4.2 5.1 9.4 3.0 2.5 1.2 1.5 2.9 2.2 2.2 3.1 2.5 2.5 2.8 0.7 1.8 -1.8 0.4 -2.8 1.9 1.0 2.2 1.9 2.7 2.9
Loud music exposure frequency 0.3 0.4 2.3 -0.5 -0.6 0.9 -0.5 -0.4 -0.7 -0.0 -1.3 -0.8 -0.3 -0.5 1.5 -0.3 -0.4 0.4 0.3 0.0 0.2 -0.2 -0.3 0.2 -0.5
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 4.7 1.4 1.4 0.6 0.2 0.9 -0.9 1.4 2.2 -0.2 0.6 0.5 -0.8 -0.3 -0.6 1.8 0.3 0.6 1.7 -1.8 1.5 -0.4 0.7
Mouth/teeth dental problems: Bleeding gums 2.1 2.7 7.5 -2.2 -2.7 -2.0 -0.1 -1.8 -0.3 -2.1 -1.5 -0.7 -1.6 -1.4 -1.2 -0.8 0.3 -2.1 -0.9 -1.8 -2.3 1.0 -2.3 -1.5 -1.8
Blood clot in the leg (DVT) 1.0 1.3 7.0 -0.6 -0.8 -0.8 1.8 -0.0 0.7 -0.4 -1.0 0.2 -0.0 -0.3 0.4 0.6 -0.7 -1.9 -2.1 -0.5 -1.8 2.7 -1.5 0.1 -0.0
Medication: Paracetamol 0.9 1.4 6.1 1.0 -0.6 -0.1 0.5 0.9 1.4 1.1 2.3 2.5 1.4 1.4 -0.6 0.1 -1.6 -0.5 -1.3 0.6 -0.5 1.3 0.4 1.7 1.0
Headache pain in last month 3.1 5.3 11.0 3.1 1.5 1.9 1.9 3.0 1.6 2.7 3.0 3.2 2.6 2.8 0.3 1.6 -1.1 1.0 -1.9 2.5 1.2 1.9 2.1 3.0 3.3
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 6.2 1.8 1.0 1.7 -0.2 1.4 0.4 2.5 0.4 1.5 1.6 1.3 0.8 1.4 -2.1 2.4 0.3 2.3 2.2 -0.5 1.9 1.3 1.3
Glaucoma (self-reported) 0.2 0.3 1.3 -1.1 -0.0 -0.6 0.1 -0.3 -0.1 -1.0 -1.1 -0.2 -0.4 -0.5 -0.2 0.1 -0.5 -0.2 -0.4 -0.1 -0.1 0.2 -0.5 -0.8 -0.2
Gout (self-reported) 0.2 0.3 1.6 0.1 0.2 0.2 -0.8 -0.2 -0.3 -0.4 -0.5 -0.4 -0.5 -0.1 0.6 -0.3 1.3 0.4 1.1 -0.5 0.4 -0.8 0.1 -0.5 -0.4
Hypothyroidism/myxoedema (self-reported) 7.4 14.5 27.6 5.2 5.2 3.5 1.0 4.5 2.6 4.8 4.5 4.1 4.3 4.6 1.3 2.4 -2.0 3.8 -1.4 3.9 3.8 0.4 5.1 4.6 4.6
Medication: Amlodipine 1.6 2.2 9.3 -2.4 -2.0 -1.0 -1.3 -1.9 -0.7 -1.9 -3.1 -1.5 -1.4 -2.0 0.6 -1.0 -0.7 -0.5 0.9 -0.9 -0.6 -0.2 -1.4 -1.4 -1.8
Medication: Ventolin 100micrograms inhaler 0.5 0.7 2.6 -0.4 -0.8 -1.3 0.3 -0.6 0.0 -0.8 0.6 1.2 -0.4 -0.1 -1.6 0.0 0.3 -1.1 -0.7 -0.8 -1.2 0.4 -1.0 -0.8 -0.7
Birth weight 0.6 1.2 4.3 -0.0 0.1 1.5 -1.3 0.4 -0.9 0.3 -1.8 -1.0 -0.2 -0.2 1.8 0.2 0.4 2.1 2.1 0.8 1.6 -1.2 0.9 0.1 0.1
Chronic bronchitis/emphysema (mother) 6.2 7.2 13.7 3.2 2.8 2.0 2.2 3.6 3.7 2.4 2.2 3.0 3.5 3.5 0.7 2.5 -1.7 0.6 -2.5 2.5 1.6 1.9 2.8 3.6 3.4
High blood pressure (siblings) 0.3 0.4 2.0 -0.7 -0.8 -0.2 -1.1 -0.7 -0.3 -0.9 -0.0 -0.5 -0.7 -0.4 0.2 -1.0 -0.2 -0.9 -0.4 -1.4 -0.6 -0.1 -0.4 -0.4 -0.4
Forced vital capacity (FVC), Best measure 0.5 1.7 12.2 -0.2 0.1 0.6 -0.7 -0.3 -2.6 0.1 -0.1 -0.5 -1.1 -1.2 -0.1 -0.9 1.5 1.0 3.5 -0.8 0.8 -3.1 0.5 -0.4 -0.4
Body fat percentage 0.3 1.0 5.0 0.3 -1.0 0.8 -0.3 -0.1 1.4 -0.5 -0.9 -0.4 0.1 0.2 2.1 1.6 -0.4 -1.3 -1.7 -0.1 -0.6 2.2 -0.6 0.0 -0.0
Leg fat percentage (right) 0.5 1.8 13.0 0.2 -1.2 0.2 0.8 0.1 2.0 -0.5 -1.2 0.0 0.2 0.3 1.9 1.2 -0.9 -2.0 -2.4 0.0 -1.3 3.6 -1.2 0.3 0.0
Arm fat-free mass (right) 0.8 4.3 13.6 -2.7 -3.3 -0.9 -0.1 -1.9 -0.7 -2.2 -3.7 -2.4 -2.0 -2.6 1.4 -1.3 0.2 -2.5 -0.0 -2.2 -2.3 1.2 -2.8 -1.8 -1.8
Exposure to tobacco smoke outside home 0.2 0.2 0.6 0.1 -0.5 0.2 -0.3 0.4 0.0 0.5 0.7 0.7 0.3 0.3 -0.3 0.0 0.2 0.8 0.6 0.4 0.6 -0.5 0.6 0.8 0.4
Comparative body size at age 10 5.1 14.0 38.2 -5.1 -5.2 -2.3 -1.1 -4.5 -1.9 -4.6 -6.2 -4.6 -4.1 -4.6 0.7 -2.8 0.9 -3.1 0.8 -3.3 -3.4 0.2 -4.8 -4.1 -4.8
Number of full brothers 0.6 0.7 3.7 -0.1 -1.3 1.1 0.2 0.2 0.8 0.0 -1.6 0.1 0.1 -0.2 1.9 0.3 -0.7 -1.3 -0.7 0.3 -0.4 1.5 -0.8 0.6 0.1
Worry too long after embarrassment 1.7 2.8 26.0 1.4 1.1 -0.3 0.2 1.2 -0.9 1.2 5.1 2.6 1.0 1.2 -2.7 -0.7 1.3 1.2 0.6 0.5 0.9 -1.9 1.5 0.6 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.9 -0.5 0.1 0.8 -1.7 -0.7 -0.6 -0.5 -0.5 -0.4 -0.8 -0.8 0.9 -0.5 0.1 0.4 1.0 0.1 0.7 -1.0 -0.1 -0.6 -1.0
Wheeze or whistling in the chest in last year 1.1 1.9 5.4 -1.3 -1.7 -1.2 -0.4 -1.7 0.2 -2.0 -1.3 -0.3 -1.4 -1.0 0.1 -0.7 0.0 -2.3 -0.9 -1.5 -1.9 1.5 -2.3 -1.6 -1.5
Number of children fathered 2.1 2.4 7.7 -1.4 -2.1 -0.8 0.6 -0.9 -0.9 -1.4 -0.4 -1.2 -1.7 -1.6 0.5 -2.1 1.8 -2.8 -0.3 -2.1 -2.7 0.8 -2.2 -0.8 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 3.5 0.7 0.3 0.4 0.2 0.7 -0.6 0.5 1.9 0.4 0.3 0.7 -0.1 -0.1 0.7 0.7 0.6 -0.1 0.4 -0.8 0.9 0.6 0.8
Age at first live birth 1.7 3.0 11.1 2.2 3.3 1.2 0.8 1.6 -0.4 2.3 1.7 1.5 1.4 1.4 0.1 0.9 0.4 3.3 1.3 1.9 2.3 -1.2 2.0 0.5 1.6
Pulse wave peak to peak time 3.7 4.3 13.1 2.2 2.4 1.8 -0.2 1.6 1.2 2.9 -0.3 1.7 2.3 1.9 1.4 2.4 -2.1 3.6 1.5 3.0 2.8 0.3 2.4 2.0 1.6
Health satisfaction 1.4 1.8 8.4 -1.1 -1.6 -1.4 1.5 0.3 0.3 -1.9 0.5 -0.6 -1.0 -0.4 -1.5 -0.8 1.4 -2.9 -0.7 -1.9 -2.1 1.5 -1.2 -0.1 0.5
Shortness of breath walking on level ground 0.3 0.4 1.6 0.5 1.0 -0.2 0.1 0.2 0.8 -0.0 0.8 1.3 -0.0 0.6 -0.2 0.2 -0.9 -0.7 -0.9 -0.2 -0.5 1.1 -0.3 -0.0 0.7
Qualifications: College or University degree 0.1 0.5 1.7 0.3 -0.3 0.6 0.6 0.5 -0.3 0.8 0.0 0.3 0.9 0.3 -0.4 0.8 -1.3 1.3 1.0 1.0 0.6 -0.7 0.6 0.3 0.0
Eye problems/disorders: None of the above 0.9 1.1 3.0 1.2 1.2 0.7 0.8 1.0 1.5 1.7 -0.1 0.7 1.4 1.0 1.0 0.4 -1.0 0.7 0.3 1.2 0.5 1.3 0.7 1.7 0.8
Mouth/teeth dental problems: Loose teeth 0.9 1.1 5.9 -0.6 -0.4 -0.3 0.5 -0.4 1.2 -0.7 -1.3 -0.7 -0.0 -0.3 0.6 0.0 -1.9 -1.7 -1.6 -0.4 -1.1 2.4 -1.0 0.4 -0.1
Emphysema/chronic bronchitis 2.4 2.7 7.7 -1.7 -2.5 -2.5 1.8 -1.1 0.3 -1.5 -0.5 0.0 -0.9 -0.9 -1.5 -0.5 0.3 -2.8 -1.1 -1.3 -2.6 2.2 -2.7 -1.6 -1.2
Medication for pain relief, constipation, heartburn 0.8 1.4 7.0 -0.9 -0.7 0.2 -1.0 -1.0 -1.8 -0.6 -1.6 -2.6 -1.4 -1.2 0.6 -0.4 0.9 0.5 1.1 -0.6 0.6 -1.9 -0.0 -1.2 -1.2
Neck or shoulder pain in last month 1.4 2.0 5.7 1.2 0.6 1.2 0.4 1.3 2.0 1.4 -0.2 2.2 1.4 1.4 1.4 0.6 -2.4 0.3 -2.0 1.5 0.5 2.0 0.7 1.9 1.4
Medication: Blood pressure 3.0 5.2 12.6 -3.3 -2.7 -2.6 -0.1 -2.5 -0.2 -3.6 -2.2 -2.2 -2.1 -2.2 -0.8 -1.9 0.9 -3.4 -0.2 -2.8 -2.9 0.8 -2.9 -2.1 -2.4
Angina (self-reported) 0.6 0.8 2.3 -0.5 -0.9 -1.1 1.2 -0.4 -0.0 -0.6 -0.2 0.4 -0.4 -0.7 -0.2 -0.9 0.7 -1.5 -1.1 -0.8 -1.5 1.3 -1.4 -0.9 -0.7
Migraine (self-reported) 0.2 0.2 1.0 0.7 0.7 0.4 0.1 0.3 0.2 -0.2 1.0 0.7 0.0 0.3 -0.3 0.4 0.2 -0.5 -0.7 -0.3 -0.1 -0.0 0.2 0.1 0.5
Medication: Ibuprofen 2.4 2.8 7.9 1.6 0.2 0.5 0.5 1.2 2.8 1.4 2.3 2.6 2.2 2.2 -0.2 1.6 -2.3 -0.2 -1.8 2.0 0.6 1.8 1.0 1.7 1.9
Medication: Allopurinol 0.2 0.2 1.6 0.1 0.3 0.7 -0.0 0.1 0.3 -0.4 -0.6 0.4 -0.4 0.0 1.3 0.1 0.8 -0.3 0.3 -0.6 -0.4 0.7 -0.4 0.1 0.2
Medication: Omeprazole 0.7 0.8 4.1 -1.1 -0.7 -0.2 -0.9 -0.9 -0.3 -0.7 -2.0 -0.5 -0.2 -1.2 0.6 -0.9 0.1 0.3 2.0 -0.6 -0.5 -0.1 -0.8 -0.3 -1.1
Medication: Seretide 50 evohaler 0.3 0.4 1.9 -0.1 -0.4 -0.9 0.8 -0.0 0.1 -0.3 0.5 1.0 0.0 0.2 -0.5 0.5 0.1 -0.8 -1.4 -0.1 -1.1 0.9 -0.7 -0.2 0.3
Mean time to correctly identify matches 0.1 0.2 0.9 -0.3 1.0 0.1 0.2 0.1 -0.3 -0.0 -0.5 0.3 -0.4 -0.4 0.3 -0.2 -0.0 -0.3 -0.7 -0.5 0.5 -0.5 -0.1 -0.7 -0.3
Heart disease (mother) 1.6 1.9 6.2 -0.8 -0.4 -1.3 -0.3 -1.4 -0.7 -1.7 1.3 -0.1 -1.0 -0.9 -1.6 -2.5 1.8 -2.0 -0.6 -1.9 -2.5 0.5 -1.6 -0.5 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.3 3.9 7.8 2.8 2.0 2.5 1.0 2.3 1.0 2.7 2.1 2.3 2.3 2.2 1.9 1.5 -1.6 1.5 -0.9 2.0 1.4 0.9 1.8 2.5 2.2
Whole body fat mass 0.4 1.7 6.1 -0.6 -2.0 0.6 -0.4 -0.8 0.8 -1.0 -2.1 -1.3 -0.5 -0.8 2.5 0.9 -0.3 -1.9 -1.3 -0.9 -1.2 2.2 -1.5 -0.6 -0.8
Leg fat mass (right) 0.8 2.9 9.3 -1.2 -2.5 0.0 0.1 -1.1 1.0 -1.6 -2.9 -1.6 -0.9 -1.2 2.4 0.5 -0.5 -2.7 -1.5 -1.1 -2.0 3.1 -2.4 -0.8 -1.2
Arm predicted mass (right) 1.1 5.7 15.4 -3.1 -3.7 -1.1 -0.3 -2.3 -1.1 -2.6 -3.9 -2.7 -2.4 -3.0 1.4 -1.8 0.4 -2.8 0.2 -2.6 -2.7 1.1 -3.2 -2.2 -2.3
Pulse rate, automated reading 0.5 1.7 6.8 1.0 1.7 2.0 0.4 2.0 0.2 1.1 -0.5 0.5 0.9 1.2 1.8 2.6 1.3 0.2 -1.2 1.2 1.7 0.5 1.2 0.7 1.7
Alcohol intake frequency. 0.2 0.4 1.8 0.3 1.2 1.0 -1.1 -0.3 0.3 -0.4 -0.5 -0.6 -0.5 -0.3 1.3 -1.2 0.6 -0.1 -0.2 -0.5 -0.1 0.3 -0.2 0.6 -0.4
Comparative height size at age 10 0.8 4.2 7.7 -2.4 -1.2 -1.1 -2.2 -2.6 -2.8 -2.2 -2.2 -2.0 -2.6 -2.5 0.1 -2.6 1.6 -0.5 2.4 -2.1 -1.0 -1.8 -1.7 -2.4 -2.3
Number of full sisters 0.9 1.1 3.5 -0.7 -1.9 0.4 -0.9 -1.1 -0.4 -0.8 -1.8 -0.4 -1.2 -1.0 1.7 -0.1 0.5 -1.2 -0.1 -1.0 -1.1 0.4 -1.5 -0.8 -1.0
Suffer from ‘nerves’ 4.5 7.1 13.0 3.6 3.1 2.5 -0.2 2.9 1.3 3.2 3.3 3.6 3.0 3.1 0.6 1.9 -0.1 3.1 0.7 3.3 3.0 -0.7 3.5 2.8 3.1
Overall health rating 0.8 1.8 7.9 -0.9 -2.4 0.4 -0.1 -0.4 0.3 -1.5 -1.9 -0.4 -1.3 -0.9 2.0 0.2 0.3 -2.8 -1.2 -1.5 -1.6 1.7 -1.6 -0.3 -0.7
Chest pain or discomfort 0.3 0.4 2.2 -0.2 -1.5 -0.9 0.9 0.4 -0.5 -0.1 1.1 0.3 0.0 -0.2 -1.0 -0.8 0.4 -0.3 -0.3 0.1 -0.2 -0.2 -0.4 -0.5 0.6
Had major operations 0.4 0.5 2.7 0.4 -0.6 -0.2 0.8 0.5 0.8 -0.1 0.9 1.1 0.2 0.7 -0.5 0.4 -0.2 -1.2 -1.6 0.0 -0.6 1.0 -0.2 0.6 0.3
Age at last live birth 2.9 4.2 18.6 2.2 3.2 1.3 -0.2 1.3 -0.7 2.7 1.4 1.3 1.6 1.4 0.2 1.3 -0.4 4.3 2.4 2.4 3.5 -2.2 2.6 0.2 1.2
Family relationship satisfaction 0.6 0.8 5.8 0.9 0.7 -0.1 0.7 0.8 -0.2 0.5 2.4 1.5 0.5 0.6 -1.0 -0.3 1.2 -0.3 -0.6 -0.2 -0.3 0.5 0.4 0.4 1.4
Leg pain on walking 1.3 1.7 8.0 -1.0 -1.0 -1.6 1.1 -0.6 -0.1 -1.2 0.0 -0.2 -0.6 -0.7 -0.8 -1.6 0.9 -2.8 -1.4 -1.5 -2.2 1.3 -1.9 -1.1 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 3.5 1.4 0.6 0.9 -0.2 1.0 0.7 1.9 0.1 0.8 1.1 1.1 0.5 1.7 0.0 1.5 0.5 1.0 1.4 -0.2 1.5 0.7 1.2
Commuting to job workplace: Car/motor vehicle 0.4 0.4 3.6 0.3 0.3 0.7 -0.2 -0.2 -0.1 0.2 -1.5 -0.3 -0.1 -0.3 1.9 0.6 0.1 0.7 1.0 0.4 0.6 -0.1 -0.1 -0.2 -0.5
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 4.0 -0.2 0.6 -0.2 0.1 -0.3 0.2 0.3 -2.0 -0.5 0.3 -0.4 0.7 0.0 -1.2 0.7 0.1 0.1 0.4 0.5 -0.1 -0.4 -0.3
Medication: Aspirin 1.0 1.3 3.7 -1.9 -0.5 -1.2 -0.2 -1.3 -0.6 -1.6 -1.9 -0.6 -1.0 -1.4 -0.2 -0.7 0.7 -0.9 0.3 -1.5 -1.2 0.2 -1.5 -1.7 -1.5
Supplements: Vitamin C 4.1 4.9 19.4 -1.9 -1.6 -3.0 4.4 -0.1 1.3 -2.2 0.1 -0.1 -0.7 -0.3 -2.2 -1.4 0.1 -3.9 -2.4 -1.8 -3.7 3.6 -2.6 0.1 -0.1
Knee pain experienced in last month 0.2 0.3 1.2 -0.5 -0.8 0.2 -0.6 -0.4 -0.2 -0.3 -0.7 0.1 -0.2 -0.7 1.1 -0.5 0.0 -0.5 -0.5 -0.2 -0.6 0.2 -0.9 -0.6 -0.7
Hypertension (Self-reported) 3.2 9.0 21.6 -4.3 -4.2 -3.6 0.2 -3.1 0.2 -4.5 -2.9 -2.3 -2.7 -2.6 -1.1 -2.6 0.5 -4.6 -1.2 -3.7 -3.8 2.3 -3.8 -2.7 -2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 2.3 0.4 -0.2 0.8 -0.4 0.3 0.9 0.3 -0.6 1.0 0.9 0.3 0.8 0.8 -1.1 0.1 0.2 0.8 0.1 1.0 0.4 1.5 0.4
Illnesses of father: Heart disease 0.2 0.2 1.0 -0.2 -0.2 -0.3 -0.8 -0.9 -0.4 -0.6 0.3 0.0 -0.4 -0.4 -0.3 -0.1 -0.3 0.2 0.5 -0.5 -0.2 -0.8 -0.2 -0.3 -1.0
Illnesses of siblings: Diabetes 0.6 0.8 4.0 -0.0 -0.1 -1.1 1.1 0.1 0.8 -0.5 1.1 0.3 0.0 0.4 -0.8 0.0 0.8 -2.0 -1.3 -1.1 -1.1 1.2 -0.8 -0.6 0.3
Smoking status: Previous 0.9 1.4 4.9 0.0 -0.3 -0.6 1.9 0.6 1.9 -0.3 1.1 1.3 0.8 1.0 -0.2 0.3 -1.4 -1.9 -2.1 -0.4 -1.3 2.2 -0.4 1.0 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 1.8 0.2 -0.3 -0.2 -1.0 -0.2 -0.4 0.1 1.1 -0.4 -0.0 -0.2 -0.7 -0.6 0.1 0.4 1.3 -0.3 -0.1 -0.9 0.3 0.4 -0.3
Whole body fat-free mass 1.0 5.9 17.9 -3.2 -3.7 -0.8 -1.1 -2.6 -1.4 -2.5 -4.2 -3.4 -2.5 -3.2 1.7 -1.7 0.2 -2.3 0.8 -2.6 -2.2 0.5 -3.0 -2.2 -2.5
Leg fat-free mass (right) 1.4 7.6 24.8 -3.5 -3.9 -0.5 -1.6 -3.0 -1.7 -2.8 -5.0 -4.1 -2.9 -3.7 2.2 -1.4 0.3 -2.3 1.2 -2.9 -2.3 0.1 -3.2 -2.6 -3.0
Arm fat percentage (left) 0.7 3.0 7.2 -1.7 -2.5 -0.4 -0.5 -1.7 0.5 -2.1 -2.7 -2.0 -1.4 -1.5 1.7 0.3 -0.2 -2.6 -1.3 -1.6 -1.9 1.9 -2.3 -1.5 -1.7
Average weekly red wine intake 0.3 0.5 1.2 -1.0 -0.5 -1.0 0.5 -0.7 -0.4 -1.1 -0.2 -0.7 -0.6 -0.5 -1.0 -0.4 0.4 -0.7 0.1 -0.6 -0.9 0.1 -0.9 -0.7 -0.7
Handedness (chirality/laterality): Left-handed 2.0 2.4 5.2 1.4 1.2 1.8 0.9 1.6 1.6 1.9 -0.7 0.9 1.9 1.5 2.3 1.7 -2.0 0.8 -0.8 1.6 1.4 1.4 1.4 2.3 1.5
Mood swings 3.9 7.1 14.0 3.7 3.5 3.2 0.3 3.1 1.0 3.0 2.8 2.6 2.6 2.9 1.2 1.9 -0.6 3.2 1.0 2.9 3.3 -0.7 3.7 3.1 3.1
Loneliness, isolation 0.4 0.5 1.7 -0.1 0.6 1.1 -1.1 0.0 -1.2 -0.2 1.0 -0.4 -0.6 -0.3 0.2 -0.8 1.1 0.4 0.7 -0.0 0.4 -1.3 0.4 0.4 0.3
Long-standing illness, disability or infirmity 0.4 0.6 4.0 1.0 1.3 0.9 0.3 0.2 0.9 -0.7 0.4 0.5 0.0 0.6 1.3 -0.1 -0.9 -0.9 -2.0 -0.5 -0.5 0.7 -0.1 0.2 -0.1
Ever had bowel cancer screening 0.2 0.3 1.8 0.6 0.7 0.3 -0.6 0.0 -0.2 0.5 0.3 -0.1 0.6 0.2 0.0 0.2 -0.1 1.3 0.7 0.6 0.7 -0.8 0.7 0.0 -0.1
Diabetes diagnosed by doctor 0.5 0.7 2.3 -0.9 -0.9 -0.9 -0.1 -0.9 -0.2 -1.5 -0.4 -0.2 -1.2 -1.0 -0.2 -0.4 0.4 -1.3 0.2 -1.4 -1.2 0.3 -1.1 -1.0 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 6.1 -1.2 -1.5 -2.0 0.9 -0.4 1.3 -0.3 -1.4 0.1 0.1 -0.2 -1.2 0.5 -1.4 -1.1 -0.8 0.1 -1.4 2.5 -1.5 -0.1 -0.6
Friendships satisfaction 0.8 1.0 3.3 0.0 -0.9 -1.0 1.8 0.4 0.4 -0.5 1.2 0.9 -0.2 0.1 -0.8 -0.8 0.5 -1.6 -1.8 -0.4 -1.3 1.7 -0.9 -0.2 0.6
Qualifications: nursing, teaching 0.3 0.4 1.9 0.4 -0.6 0.1 0.4 0.4 -1.0 0.9 -0.0 0.3 0.4 -0.1 -0.4 0.8 0.5 1.4 0.8 0.7 0.9 -1.0 0.4 -0.3 0.1
Commuting to job workplace: Walk 0.4 0.4 3.0 0.5 -0.3 0.3 -0.4 0.2 0.7 0.3 0.8 0.8 0.5 0.6 -0.2 -0.3 -1.2 -0.4 -1.7 0.3 -0.2 0.8 0.1 0.4 0.6
Eye problems/disorders: Cataract 0.5 0.6 2.8 0.7 -0.0 1.1 -1.7 0.4 -0.9 0.3 0.7 0.3 -0.2 0.4 0.1 0.8 0.1 0.8 -0.3 -0.0 1.3 -1.4 1.2 -0.2 0.9
Mouth/teeth dental problems: Mouth ulcers 4.0 6.4 13.4 2.8 2.7 2.4 2.4 3.6 2.4 2.8 1.2 2.4 2.8 2.8 1.5 2.2 -1.6 2.1 -1.3 2.9 2.1 1.6 2.7 3.7 3.7
Medication for cholesterol 0.9 1.3 5.9 0.5 1.1 0.9 -1.2 -0.1 -1.7 0.9 1.7 -0.5 0.0 -0.2 -0.3 0.5 1.4 1.8 2.4 0.5 1.1 -2.3 0.8 -0.2 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.5 6.0 1.1 0.9 0.7 1.1 1.3 2.0 0.9 0.1 2.0 1.3 1.1 1.3 1.0 -0.0 -0.7 -1.5 0.9 -0.4 2.4 -0.1 1.2 1.1
Back pain experienced in last month 0.8 1.2 3.2 1.3 0.3 1.6 0.2 1.2 0.9 0.7 -0.2 1.6 0.5 1.0 1.8 1.1 -1.3 -0.8 -1.7 -0.0 0.1 1.5 0.5 1.3 1.0
Mineral and other dietary supplements 1.5 2.1 5.2 2.0 2.2 1.9 -0.1 1.5 -0.4 1.8 1.2 1.1 1.5 1.0 0.7 0.8 -0.7 2.2 0.4 2.3 1.8 -0.9 1.7 1.4 1.1
Breast cancer (self-reported) 0.5 0.5 1.5 0.8 0.8 1.2 0.7 0.9 0.9 0.3 -0.2 0.4 0.6 0.7 1.2 1.0 0.2 -0.0 -1.1 0.7 0.2 0.6 0.3 0.9 0.6
Asthma (self-reported) 0.3 0.7 2.3 -0.8 -0.6 -0.2 -1.1 -1.2 0.4 -1.1 -1.5 0.4 -1.0 -0.6 0.6 0.7 -0.5 -0.6 -0.5 -0.5 -0.7 0.4 -1.0 -0.9 -1.4
Osteoporosis (self-reported) 1.4 1.7 4.3 1.7 2.1 1.2 -0.9 1.3 0.8 1.4 2.0 0.8 1.3 1.6 -0.2 0.1 0.7 1.5 0.2 1.2 1.5 -0.9 2.0 1.5 1.3
Osteoarthritis (self-reported) 1.5 1.9 9.0 0.7 0.2 0.1 1.7 1.1 2.5 0.1 0.4 1.2 1.2 1.1 0.7 0.7 -1.9 -1.7 -3.0 0.7 -0.8 2.8 -0.4 1.1 1.0
Medication: Aspirin 1.6 2.0 4.7 -2.2 -0.9 -1.4 -0.2 -1.7 -0.9 -2.0 -1.6 -0.9 -1.4 -1.7 -0.5 -1.4 0.8 -1.4 -0.1 -1.9 -1.7 0.1 -1.9 -1.8 -1.8
Medication: Gliclazide 0.9 1.0 2.5 -1.1 -0.4 -1.4 0.7 -0.6 0.3 -1.6 -1.3 -0.4 -0.7 -0.9 -0.8 -0.5 0.1 -1.5 -0.3 -1.3 -1.5 0.7 -1.3 -1.1 -1.1
Illnesses of father: None of the above (group 1) 0.6 0.7 3.4 0.4 1.0 0.2 1.9 1.5 -0.5 0.8 1.2 1.0 0.6 0.5 -0.6 -0.1 0.8 0.3 -0.6 0.7 0.6 -0.2 0.5 0.1 1.5
Smoking status: Current 2.9 4.5 13.7 -2.5 -3.6 -2.3 1.2 -2.1 0.2 -2.3 -3.0 -1.0 -1.5 -1.8 -0.1 -0.4 0.2 -3.0 -0.7 -1.2 -3.0 2.4 -3.7 -1.8 -2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.9 4.0 10.3 2.1 2.6 2.8 0.2 2.0 -1.1 2.2 0.8 0.2 1.3 0.7 1.5 1.1 0.0 3.0 2.8 1.9 3.2 -2.5 2.9 1.7 2.0
Whole body water mass 1.1 6.2 18.0 -3.3 -3.8 -0.9 -1.1 -2.7 -1.5 -2.6 -4.2 -3.4 -2.6 -3.3 1.6 -1.8 0.2 -2.3 0.8 -2.6 -2.3 0.3 -3.0 -2.4 -2.6
Leg predicted mass (right) 1.4 7.3 23.7 -3.5 -3.9 -0.5 -1.5 -2.9 -1.6 -2.8 -4.9 -4.0 -2.9 -3.6 2.2 -1.3 0.3 -2.3 1.1 -2.9 -2.3 0.1 -3.1 -2.5 -2.9
Arm fat mass (left) 1.0 4.1 11.9 -2.1 -3.0 -0.4 -0.6 -2.0 0.1 -2.4 -3.4 -2.6 -1.7 -2.1 2.1 -0.0 -0.0 -2.9 -1.0 -2.0 -2.3 2.0 -2.8 -1.8 -2.0
Number of self-reported non-cancer illnesses 0.6 1.0 4.6 0.5 0.9 -0.4 1.1 1.1 1.7 -0.2 1.1 1.2 0.8 1.3 -0.5 0.7 -0.7 -0.9 -2.1 0.2 -0.2 1.3 0.4 0.9 1.0
Average weekly champagne plus white wine intake 0.3 0.4 1.4 0.3 0.3 -0.7 1.2 0.5 0.9 0.1 0.2 0.5 0.5 0.5 -1.0 0.8 -0.7 0.3 -0.1 0.4 0.3 0.8 0.4 0.0 0.8
Miserableness 2.0 3.4 17.4 2.4 2.0 0.7 0.0 1.9 -0.1 1.5 4.2 2.8 1.6 2.2 -1.7 -0.2 0.0 2.0 0.1 1.5 1.7 -1.4 2.4 1.7 2.2
Guilty feelings 1.4 2.1 13.9 1.1 1.3 -0.7 -0.2 0.7 -1.1 1.0 3.7 2.0 0.5 0.9 -2.7 -1.1 1.4 1.7 0.8 0.7 0.9 -2.1 1.2 -0.0 0.6
Wears glasses or contact lenses 1.0 1.2 3.1 1.5 0.9 0.5 0.7 1.3 1.2 0.4 1.8 1.3 1.3 1.5 -0.6 1.3 -0.1 0.1 -1.4 0.9 1.0 0.1 1.3 1.0 1.1
Ever taken oral contraceptive pill 0.5 0.5 1.3 1.0 0.6 0.2 0.9 0.9 0.8 0.4 0.8 0.2 0.7 0.9 0.2 1.1 -0.9 0.2 -0.1 1.1 0.3 0.9 0.5 0.6 0.7
Hearing aid user 0.2 0.2 1.7 -0.2 -0.2 -0.5 0.4 0.1 0.6 -0.1 0.4 0.5 -0.0 -0.0 -0.6 -1.3 -0.2 -0.3 -0.5 -0.2 -0.4 0.5 -0.2 0.1 0.3
Mother’s age at death 0.8 1.0 2.8 1.3 1.6 -0.4 0.1 0.7 0.5 1.0 1.7 1.6 0.7 1.1 -1.0 1.0 0.7 1.0 -0.4 1.1 1.1 0.0 1.2 -0.1 0.8
Financial situation satisfaction 0.7 0.9 2.5 -1.1 -0.4 -0.7 -0.1 -0.5 -0.4 -1.4 -0.2 -1.3 -1.2 -1.1 -0.6 -1.0 0.7 -1.6 0.8 -1.5 -1.2 0.1 -1.1 -0.7 -0.3
Tinnitus: Yes, now most or all of the time 2.2 2.6 4.9 1.8 0.9 2.0 1.0 2.1 1.3 2.2 -0.2 1.9 1.9 1.6 1.8 1.6 -1.2 1.4 -0.5 2.2 1.6 0.8 1.5 1.9 2.0
Commuting to job workplace: Public transport 0.6 0.7 2.9 0.8 0.4 -0.2 -0.9 0.1 0.1 0.9 1.3 1.7 0.9 1.0 -1.7 0.2 -0.3 1.2 0.2 0.8 0.7 -0.4 0.8 0.1 0.5
Eye problems/disorders: Glaucoma 0.8 1.0 6.0 -1.7 -0.6 -0.5 -0.0 -0.7 -0.7 -1.4 -2.4 -1.4 -1.0 -1.2 0.2 -0.4 -0.3 -0.2 0.5 -0.3 -0.3 -0.2 -1.1 -1.2 -1.0
Medication: Blood pressure 4.1 7.9 17.1 -3.7 -4.1 -3.3 0.4 -2.8 -0.3 -3.8 -2.8 -1.2 -2.9 -2.5 -1.2 -2.6 0.3 -4.0 -1.6 -3.5 -3.8 1.8 -3.7 -2.5 -2.7
Pain type(s) experienced in last month: Hip pain 0.8 1.0 3.8 -1.0 -0.7 -1.0 0.7 -0.2 -0.2 -1.4 0.4 0.1 -1.3 -0.8 -0.2 -1.0 0.4 -2.0 -1.7 -1.3 -1.5 0.8 -1.4 -0.7 -0.1
Supplements: Fish oil (including cod liver oil) 2.5 3.3 7.1 -2.5 -2.6 -1.4 -0.9 -2.3 -0.2 -2.5 -2.0 -1.9 -2.0 -1.8 -0.1 -1.5 0.8 -2.2 0.6 -2.7 -2.0 0.1 -2.0 -1.6 -2.2
High cholesterol (Self-reported) 0.3 0.5 2.1 -0.3 0.0 -1.2 1.1 0.1 0.6 -0.8 -0.1 -0.1 -0.1 0.4 -1.1 -0.9 1.4 -0.8 -1.1 -0.2 -0.5 1.1 -0.4 -0.3 0.2
Medication: Bendroflumethiazide 5.6 8.6 21.4 -4.0 -4.6 -3.3 -1.1 -3.5 -0.3 -3.8 -2.7 -1.8 -2.5 -2.6 -2.0 -2.4 0.5 -4.2 -0.4 -3.7 -3.8 1.2 -3.7 -2.6 -3.4
Medication: Paracetamol 0.4 0.6 2.5 0.2 -1.4 -0.6 -0.5 -0.2 0.6 0.6 1.6 1.4 0.6 0.5 -0.6 -0.9 -1.4 -0.3 -0.8 0.1 -0.6 0.6 -0.2 0.5 -0.1
Medication: Lisinopril 1.5 1.9 6.8 -1.4 -1.9 -1.9 0.8 -0.5 1.3 -1.5 -0.0 -0.0 -0.7 -0.4 -1.2 -1.3 -0.0 -2.6 -2.2 -1.3 -2.1 1.9 -1.6 -0.3 -0.3
Medication: Atorvastatin 0.6 0.7 1.9 0.9 1.1 -1.1 1.1 0.7 1.4 0.2 0.9 0.7 0.6 1.1 -1.0 0.4 0.2 0.1 -1.1 0.4 0.1 1.3 0.4 0.3 0.9
Illnesses of father: High blood pressure 0.5 0.6 2.9 -0.5 -0.6 0.1 -1.2 -1.0 0.6 -0.7 -1.6 -0.9 -0.3 -0.5 1.2 -0.3 -1.7 -0.4 -0.1 -0.4 -0.5 0.7 -0.4 0.3 -0.6
Alcohol drinker status: Never 0.5 0.6 5.9 0.7 2.4 0.1 0.3 0.5 1.0 0.4 0.9 0.5 0.6 0.4 0.1 -0.4 0.7 -0.3 -0.4 0.2 -0.1 0.9 0.4 0.9 0.7
Ever smoked 0.7 1.3 5.0 0.1 -0.8 -0.2 1.4 0.4 2.2 0.3 -0.4 1.0 1.3 1.1 0.4 1.2 -2.0 -0.8 -1.5 1.0 -0.6 2.2 -0.5 1.1 0.3
Basal metabolic rate 1.1 6.0 17.7 -3.1 -3.7 -0.7 -1.2 -2.6 -1.3 -2.5 -4.2 -3.4 -2.5 -3.2 1.9 -1.5 0.3 -2.4 0.7 -2.6 -2.3 0.6 -3.0 -2.3 -2.5
Leg fat percentage (left) 0.4 1.6 11.3 -0.0 -1.1 0.2 0.9 0.1 1.8 -0.5 -1.3 -0.2 0.1 0.1 1.8 1.3 -0.6 -1.9 -2.1 -0.1 -1.2 3.4 -1.3 0.1 0.1
Arm fat-free mass (left) 0.9 4.4 12.7 -2.6 -3.3 -0.9 -0.3 -2.1 -0.5 -2.2 -3.6 -2.4 -1.8 -2.5 1.6 -1.3 0.1 -2.6 -0.2 -2.2 -2.4 1.5 -2.9 -1.8 -1.9
Number of operations (self-reported) 0.8 1.2 7.1 -1.1 -2.7 -0.6 0.5 -0.6 0.7 -1.0 -0.7 -0.4 -0.5 -0.5 0.1 0.1 -0.9 -2.1 -1.5 -0.2 -1.5 1.4 -1.3 0.0 -0.7
Average weekly beer plus cider intake 2.8 4.1 13.5 2.6 1.7 1.4 0.6 2.0 1.1 2.6 3.7 3.6 2.2 2.5 -0.3 0.9 -0.8 1.4 -0.8 2.1 1.7 -0.3 2.3 2.2 2.5
Irritability 6.9 11.7 25.2 5.0 4.5 4.2 -0.8 3.7 0.3 4.2 4.5 3.3 3.2 3.4 1.5 1.6 -1.3 4.4 0.2 3.8 4.4 -2.0 4.7 3.4 3.4
Risk taking 2.1 3.0 6.3 -2.2 -2.4 -1.5 0.6 -1.6 -1.6 -2.1 -2.5 -2.4 -1.9 -2.3 -0.3 -0.3 1.8 -0.8 1.8 -1.6 -1.4 -0.0 -2.1 -1.9 -1.7
Ever had prostate specific antigen (PSA) test 0.7 0.8 5.1 0.3 -0.5 -0.1 -0.2 0.2 -0.3 0.6 -0.9 -0.7 0.4 0.2 0.0 0.8 -0.3 2.3 1.7 1.3 1.3 -1.1 0.9 0.1 -0.1
Fractured/broken bones in last 5 years 0.3 0.4 1.5 0.7 1.0 0.6 -0.3 0.3 1.2 0.6 0.1 0.1 1.2 0.8 0.5 -0.0 -0.4 -0.5 -0.1 0.6 0.4 0.4 0.4 0.8 0.1
Age started oral contraceptive pill 1.3 1.6 4.5 1.6 2.1 1.3 0.7 1.4 0.1 1.7 1.2 1.7 1.4 1.2 0.9 0.7 -1.5 1.5 -0.4 1.4 1.0 0.1 1.2 1.2 1.4
Diastolic blood pressure, automated reading 3.2 10.0 28.1 -3.9 -3.4 -3.4 1.5 -2.6 0.2 -3.9 -3.7 -2.8 -3.1 -2.7 -0.2 -2.6 1.2 -5.3 -2.1 -4.1 -4.2 3.3 -4.4 -2.8 -2.6
Ever depressed for a whole week 0.3 0.4 1.3 0.7 1.1 0.7 -0.0 0.6 -0.0 0.5 1.1 0.7 0.3 0.3 0.5 -1.2 0.3 0.7 -0.0 0.1 0.6 -0.5 0.7 0.9 0.8
Unable to work because of sickness or disability 2.2 2.8 12.0 -1.9 -3.5 -1.0 -1.5 -1.9 -0.7 -2.0 -1.7 -0.8 -1.6 -1.8 -0.0 -1.7 0.4 -2.1 -0.6 -0.8 -1.9 0.8 -2.6 -1.6 -2.1
Commuting to job workplace: Cycle 0.6 0.7 3.3 -0.7 -1.1 -1.5 -0.0 -1.2 0.4 -1.0 0.4 0.5 -0.5 -0.2 -1.8 -0.4 0.2 -0.9 -0.5 -0.7 -1.2 0.6 -0.8 -1.0 -0.8
Myopia 0.4 0.5 2.3 0.9 1.2 0.3 -0.5 0.2 0.3 0.7 1.5 0.6 0.5 1.0 -0.1 0.8 0.4 0.4 0.3 -0.2 0.9 -0.5 1.2 0.3 0.6
Vascular/heart problems diagnosed by doctor 2.7 7.3 17.7 3.8 3.4 3.4 -0.4 2.7 -0.2 4.1 2.5 1.8 2.4 2.2 1.2 2.5 -0.7 4.2 1.3 3.5 3.5 -2.1 3.4 2.5 2.3
Cholesterol lowering medication 0.9 1.3 5.5 0.7 0.4 -1.0 1.5 1.0 1.5 0.0 1.3 1.9 0.8 1.5 -1.6 -0.1 -0.4 -0.8 -2.3 0.3 -0.4 1.6 0.4 0.9 1.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.7 -1.3 -1.2 -0.9 -0.2 -0.9 -0.5 -0.9 -1.3 0.0 -0.2 -1.2 -0.5 -0.9 0.5 -0.2 1.3 -0.4 -1.1 0.2 -1.1 -0.5 -1.1
Pain experienced in last month 0.9 1.4 4.7 -1.2 -0.3 -1.3 -0.2 -1.2 -1.4 -1.2 0.7 -1.2 -1.2 -1.0 -2.2 -1.1 1.7 -0.2 1.5 -1.2 -0.3 -2.0 -0.4 -1.3 -1.0
Supplements: Calcium 0.9 1.0 3.8 -0.9 -1.1 -1.7 -0.8 -0.9 0.2 -0.9 1.3 0.1 -0.5 -0.1 -1.9 -1.4 1.0 -1.3 -0.5 -1.0 -0.9 0.2 -0.6 -1.0 -0.5
Basal cell carcinoma (self-reported) 0.6 0.7 3.4 -0.9 -0.8 -0.7 1.8 0.4 -0.6 -0.7 -0.7 -0.9 -0.5 -0.9 0.1 0.1 1.1 -1.3 -0.3 -1.0 -1.1 0.7 -0.9 -0.1 -0.2
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.7 0.1 -0.2 -0.0 -0.2 -0.0 -0.4 0.1 -0.1 0.2 -0.1 -0.2 0.4 -0.1 0.9 0.1 0.3 -0.1 -0.0 -0.4 -0.1 -0.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 5.3 -1.1 -1.3 -1.1 1.5 -0.4 0.2 -0.9 -1.2 -0.2 -0.6 -0.8 0.1 0.3 -0.5 -2.1 -1.7 -1.0 -2.0 2.3 -1.8 -0.3 -0.4
Heart disease (siblings) 0.7 0.9 2.2 1.0 1.5 1.4 0.2 1.4 0.7 0.6 0.5 0.1 1.0 1.1 0.9 1.0 -0.7 0.7 -0.3 1.2 1.3 0.2 1.0 0.9 1.0
Alcohol drinker status: Previous 0.2 0.2 0.8 0.0 0.3 0.9 -0.3 0.4 -0.6 -0.3 -0.1 -0.6 -0.4 -0.4 0.9 -0.5 0.0 0.1 -0.0 -0.3 0.5 -0.6 0.1 0.1 -0.1
Pack years of smoking 0.6 0.9 4.7 -1.0 -2.2 -1.3 0.2 -0.8 1.0 -0.6 -1.6 -0.0 0.4 -0.0 -0.6 0.3 -1.0 -0.8 -0.3 0.1 -1.0 1.5 -1.0 -0.4 -1.0
Impedance of whole body 4.5 23.0 59.8 6.8 6.2 3.2 0.1 5.1 1.7 5.6 7.7 5.3 4.8 6.0 -1.4 3.8 -0.7 5.7 0.1 5.0 5.6 -2.2 6.8 4.4 5.2
Leg fat mass (left) 0.7 2.8 9.0 -1.2 -2.4 -0.0 0.1 -1.1 1.0 -1.5 -2.9 -1.6 -0.8 -1.2 2.4 0.7 -0.4 -2.6 -1.4 -1.1 -1.9 3.0 -2.3 -0.8 -1.1
Arm predicted mass (left) 0.9 4.8 13.5 -2.8 -3.5 -0.9 -0.3 -2.1 -0.6 -2.4 -3.7 -2.6 -2.0 -2.6 1.7 -1.4 0.2 -2.9 -0.2 -2.3 -2.5 1.5 -3.0 -1.9 -1.9