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chr17:6,229,268-8,879,780

Best TWAS P=2.14e-35 · Best GWAS P=8.69e-34 conditioned to 9.66e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CHRNB1	0.09	0.06	lasso	2	0.08	9.8e-10	12.03	11.9	1.7e-32	0.91	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	EIF5A	0.20	0.12	bslmm	446	0.10	1.2e-12	-4.96	-7.7	1.3e-14	-0.25	1.00	0.00	TRUE
3	CommonMind	Brain Pre-frontal Cortex	PFAS	0.10	0.09	lasso	4	0.10	8.9e-13	-5.42	-6.3	2.4e-10	0.01	0.00	1.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	9.62	9.9	3.0e-23	0.64	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	CHRNB1	0.30	0.22	lasso	8	0.26	1.6e-21	-7.37	10.2	1.7e-24	0.66	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	12.03	12.4	2.1e-35	0.93	0.01	0.99	TRUE
7	GTEx	Artery Aorta	CHRNB1	0.23	0.10	enet	7	0.13	1.3e-07	-7.26	10.2	2.7e-24	0.72	0.04	0.96	FALSE
8	GTEx	Artery Coronary	CHRNB1	0.26	0.08	enet	24	0.11	1.3e-04	9.62	7.9	4.0e-15	0.68	0.02	0.92	FALSE
9	GTEx	Artery Tibial	CHRNB1	0.27	0.20	lasso	5	0.22	8.1e-17	-7.35	10.4	3.2e-25	0.72	0.74	0.26	FALSE
10	GTEx	Artery Tibial	ZBTB4	0.15	0.05	enet	30	0.07	2.9e-06	9.86	6.0	2.1e-09	0.21	0.77	0.03	FALSE
11	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	7.64	7.6	2.1e-14	0.34	0.75	0.04	FALSE
12	GTEx	Brain Frontal Cortex BA9	PFAS	0.28	0.04	lasso	5	0.09	2.2e-03	-5.42	-5.8	7.6e-09	0.04	0.02	0.84	FALSE
13	GTEx	Breast Mammary Tissue	CHRNB1	0.23	0.07	enet	19	0.14	1.6e-07	-7.35	9.5	1.7e-21	0.75	0.00	0.99	FALSE
14	GTEx	Breast Mammary Tissue (Male)	CHRNB1	0.28	-0.01	lasso	6	0.02	9.6e-02	12.03	11.0	5.5e-28	0.84	0.01	0.84	FALSE
15	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	12.03	11.1	1.1e-28	0.73	0.01	0.99	FALSE
16	GTEx	Cells Transformed fibroblasts	PFAS	0.13	0.05	lasso	6	0.07	4.1e-06	-6.34	-6.0	2.3e-09	-0.01	0.01	0.99	FALSE
17	GTEx	Colon Sigmoid	CHRNB1	0.18	0.06	enet	18	0.11	1.3e-04	-7.35	9.7	3.1e-22	0.65	0.15	0.68	FALSE
18	GTEx	Colon Transverse	CHRNB1	0.19	0.01	enet	18	0.11	6.2e-06	9.69	5.5	3.2e-08	0.44	0.06	0.64	FALSE
19	GTEx	Esophagus Mucosa	SOX15	0.16	0.03	enet	9	0.07	2.3e-05	8.44	-5.6	2.0e-08	-0.11	0.26	0.04	TRUE
20	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	12.03	12.3	1.2e-34	0.93	0.00	1.00	FALSE
21	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	9.98	10.0	2.2e-23	0.65	0.90	0.06	FALSE
22	GTEx	Esophagus Muscularis	CHRNB1	0.35	0.19	lasso	7	0.28	1.9e-17	-7.26	10.4	1.9e-25	0.63	0.93	0.07	FALSE
23	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	9.72	9.8	1.1e-22	0.64	0.24	0.35	FALSE
24	GTEx	Heart Left Ventricle	CHRNB1	0.16	0.03	lasso	4	0.05	9.6e-04	-3.46	6.0	2.3e-09	0.39	0.08	0.42	FALSE
25	GTEx	Lung	CNTROB	0.15	0.06	enet	28	0.07	9.5e-06	-2.01	5.2	2.5e-07	0.19	0.64	0.02	FALSE
26	GTEx	Lung	CHRNB1	0.22	0.05	enet	17	0.14	7.5e-11	-6.19	10.6	3.8e-26	0.59	0.18	0.82	FALSE
27	GTEx	Muscle Skeletal	EIF5A	0.14	0.06	enet	35	0.05	4.2e-06	-4.60	-5.8	5.6e-09	-0.06	0.97	0.00	FALSE
28	GTEx	Nerve Tibial	CHRNB1	0.37	0.31	enet	12	0.35	9.7e-26	-7.26	8.7	3.6e-18	0.56	1.00	0.00	FALSE
29	GTEx	Pancreas	TRAPPC1	0.17	0.00	lasso	6	0.01	1.5e-01	9.72	10.3	9.0e-25	0.42	0.05	0.57	FALSE
30	GTEx	Prostate	RP11-104H15.8	0.54	0.01	enet	1	0.06	1.6e-02	-5.69	-5.7	1.3e-08	0.03	0.07	0.07	TRUE
31	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	12.03	12.2	5.0e-34	0.93	0.01	0.99	FALSE
32	GTEx	Skin Sun Exposed Lower leg	PHF23	0.09	0.01	lasso	7	0.00	1.5e-01	3.96	5.4	7.8e-08	0.06	0.14	0.07	FALSE
33	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	9.86	10.8	4.2e-27	0.74	0.56	0.44	FALSE
34	GTEx	Skin Sun Exposed Lower leg	RP11-849F2.9	0.13	0.00	enet	34	0.02	1.1e-02	-6.40	-5.3	1.2e-07	0.02	0.01	0.96	FALSE
35	GTEx	Small Intestine Terminal Ileum	CHRNB1	0.43	-0.01	lasso	9	0.00	2.9e-01	0.24	7.2	5.1e-13	0.26	0.04	0.25	FALSE
36	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	12.03	11.7	8.4e-32	0.86	0.00	1.00	FALSE
37	GTEx	Testis	CHRNB1	0.33	0.28	lasso	4	0.30	4.8e-14	5.15	6.8	1.1e-11	0.69	0.98	0.02	FALSE
38	GTEx	Thyroid	CHRNB1	0.11	0.03	lasso	8	0.02	7.1e-03	-7.37	8.6	6.0e-18	0.55	0.15	0.37	FALSE
39	METSIM	Adipose	CHRNB1	0.22	0.16	bslmm	486	0.20	1.2e-28	-7.35	9.0	2.2e-19	0.60	1.00	0.00	FALSE
40	METSIM	Adipose	CTC1	0.13	0.07	enet	25	0.08	5.8e-12	3.39	-5.1	2.7e-07	0.00	1.00	0.00	FALSE
41	METSIM	Adipose	FGF11	0.07	0.00	bslmm	477	0.02	1.5e-04	9.86	-8.3	7.3e-17	-0.52	0.70	0.08	FALSE
42	METSIM	Adipose	PFAS	0.10	0.00	blup	450	0.03	1.7e-05	-6.34	-5.5	3.3e-08	0.01	0.01	0.91	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	FGF11	0.08	0.04	blup	454	0.04	1.2e-05	-3.46	5.5	3.2e-08	0.51	0.97	0.02	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	12.03	11.5	1.2e-30	0.91	0.00	1.00	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	PFAS	0.08	0.02	enet	10	0.03	4.4e-05	-6.40	-5.9	4.1e-09	0.01	0.00	1.00	FALSE
46	YFS	Blood	BCL6B	0.02	0.00	bslmm	470	0.00	2.1e-02	2.29	-6.1	1.2e-09	-0.37	0.16	0.14	FALSE
47	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	12.12	11.9	6.6e-33	0.93	0.00	1.00	FALSE
48	YFS	Blood	TMEM107	0.17	0.17	lasso	5	0.19	2.0e-61	-4.97	-5.6	1.8e-08	0.02	0.92	0.08	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	AURKB	0.02	0.01	blup	49	0.01	2.9e-03	3.38	-6.6	3.5e-11	0.03	0.00	0.58	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	12.12	10.9	1.8e-27	0.89	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	PFAS	0.02	0.01	lasso	3	0.01	9.7e-03	-6.34	-6.1	1.2e-09	0.02	0.00	0.98	FALSE
52	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	12.03	9.8	7.0e-23	0.90	0.01	0.84	FALSE
53	The Cancer Genome Atlas	Glioblastoma Multiforme	AMAC1L3	0.14	0.12	lasso	3	0.12	1.8e-04	10.65	-10.8	2.1e-27	-0.92	0.01	0.82	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALOXE3	0.04	0.00	blup	77	0.01	3.4e-02	-4.95	-6.1	8.7e-10	0.08	0.00	0.54	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf68	0.05	0.00	blup	59	0.03	3.3e-04	-4.84	-7.1	1.7e-12	0.01	0.01	0.92	TRUE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	7.88	8.9	7.6e-19	0.65	0.53	0.47	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHRNB1	0.04	0.03	blup	57	0.02	1.5e-03	-3.88	5.2	2.6e-07	0.63	0.06	0.28	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	AMAC1L3	0.04	0.02	blup	54	0.02	3.9e-03	7.26	-5.4	8.5e-08	-0.34	0.28	0.06	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	10.76	12.0	3.5e-33	0.92	0.00	1.00	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	EIF5A	0.08	0.12	enet	15	0.13	1.0e-14	-4.60	-5.4	7.8e-08	-0.01	0.03	0.96	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	PFAS	0.03	0.02	blup	54	0.03	1.3e-04	-4.71	-5.3	8.9e-08	0.03	0.09	0.84	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	12.12	9.2	4.5e-20	0.84	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF5A	0.03	0.03	blup	52	0.03	4.2e-04	-4.98	-5.6	2.2e-08	0.00	0.02	0.97	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TNFSF12-TNFSF13	0.06	0.00	blup	58	0.01	3.4e-02	1.95	-5.7	1.5e-08	-0.36	0.01	0.06	FALSE
65	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C17orf68	0.13	0.08	lasso	3	0.10	6.1e-05	3.38	-5.4	7.7e-08	0.01	0.02	0.90	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	12.03	11.1	7.2e-29	0.78	0.00	1.00	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	EIF5A	0.05	0.01	blup	53	0.01	2.3e-02	-5.26	-5.2	1.6e-07	0.00	0.00	0.95	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	-2.66	-6.6	3.2e-11	-0.58	0.01	0.66	FALSE
69	The Cancer Genome Atlas	Soft Tissue Sarcoma	CHRNB1	0.07	0.03	enet	8	0.03	6.9e-03	10.76	6.9	4.8e-12	0.66	0.01	0.39	FALSE
70	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	5.26	10.6	4.0e-26	0.88	0.00	0.75	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	-3.46	9.2	3.3e-20	0.68	0.10	0.78	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	3.97	6.1	8.9e-10	0.42	0.41	0.10	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	-0.80	-5.5	3.6e-08	-0.42	0.04	0.08	FALSE