[Hub]/) : Traits : Sitting height :

chr17:60,821,100-65,498,820

Best TWAS P=3.58e-62 · Best GWAS P=2.39e-57 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex KCNH6 0.04 0.02 enet 9 0.04 1.4e-05 12.87 12.4 4.3e-35 -0.49 0.69 0.11 FALSE
2 CommonMind Brain Pre-frontal Cortex SMARCD2 0.03 0.03 blup 330 0.03 1.1e-04 13.11 10.0 2.1e-23 -0.24 0.78 0.02 TRUE
3 CommonMind Brain Pre-frontal Cortex TCAM1P 0.05 0.03 enet 8 0.04 4.1e-06 -13.44 7.4 1.6e-13 -0.62 0.83 0.16 FALSE
4 GTEx Adipose Subcutaneous CD79B 0.15 0.16 enet 9 0.17 3.5e-14 -15.59 16.6 3.6e-62 -0.98 0.00 1.00 TRUE
5 GTEx Adipose Subcutaneous MAP3K3 0.09 0.07 lasso 6 0.07 3.5e-06 12.93 12.5 4.9e-36 -0.34 1.00 0.00 FALSE
6 GTEx Adipose Visceral Omentum CD79B 0.15 0.00 lasso 6 0.02 4.1e-02 -15.59 13.5 1.1e-41 -0.89 0.03 0.78 FALSE
7 GTEx Adipose Visceral Omentum MAP3K3 0.10 0.04 enet 12 0.05 9.0e-04 12.88 12.6 1.1e-36 -0.34 0.31 0.08 FALSE
8 GTEx Artery Tibial DDX42 0.13 0.14 lasso 5 0.15 9.1e-12 12.88 -9.4 4.0e-21 0.13 1.00 0.00 FALSE
9 GTEx Artery Tibial MAP3K3 0.05 0.07 lasso 5 0.07 2.9e-06 12.76 12.8 2.1e-37 -0.39 0.83 0.02 FALSE
10 GTEx Brain Hypothalamus DDX42 0.15 0.18 lasso 3 0.09 4.2e-03 13.11 -10.1 6.9e-24 0.21 0.14 0.06 FALSE
11 GTEx Brain Nucleus accumbens basal ganglia DDX42 0.23 0.04 lasso 12 0.07 8.1e-03 12.86 -11.6 2.9e-31 0.33 0.20 0.05 FALSE
12 GTEx Brain Putamen basal ganglia DDX42 0.16 0.04 lasso 4 0.06 1.5e-02 -1.32 -5.2 2.3e-07 0.03 0.11 0.05 FALSE
13 GTEx Breast Mammary Tissue PSMC5 0.10 0.00 enet 24 0.00 4.5e-01 5.53 -6.7 1.7e-11 0.46 0.13 0.10 FALSE
14 GTEx Breast Mammary Tissue DCAF7 0.08 0.00 enet 18 0.05 1.1e-03 8.91 8.5 1.7e-17 -0.14 0.09 0.07 FALSE
15 GTEx Breast Mammary Tissue MAP3K3 0.10 0.11 lasso 8 0.08 8.9e-05 12.87 13.0 1.6e-38 -0.36 0.95 0.00 FALSE
16 GTEx Breast Mammary Tissue (Male) MAP3K3 0.12 0.14 lasso 2 0.07 1.2e-02 12.66 9.9 6.4e-23 -0.13 0.15 0.07 FALSE
17 GTEx Breast Mammary Tissue (Female) CD79B 0.04 0.07 lasso 2 0.03 4.2e-02 -14.25 14.0 8.8e-45 -0.70 0.04 0.25 FALSE
18 GTEx Breast Mammary Tissue (Female) DCAF7 0.10 0.02 lasso 3 0.00 4.4e-01 11.50 11.6 2.4e-31 -0.29 0.07 0.06 FALSE
19 GTEx Breast Mammary Tissue (Female) MAP3K3 0.07 0.01 lasso 1 0.00 4.1e-01 12.90 12.9 4.5e-38 -0.36 0.05 0.12 FALSE
20 GTEx Cells EBV-transformed lymphocytes DDX42 0.11 0.14 lasso 2 0.12 1.3e-04 12.88 -12.9 5.8e-38 0.36 0.33 0.04 FALSE
21 GTEx Cells Transformed fibroblasts CD79B 0.20 0.00 lasso 4 0.00 4.3e-01 -1.97 -7.5 7.2e-14 0.32 0.11 0.08 FALSE
22 GTEx Cells Transformed fibroblasts PSMC5 0.19 0.09 lasso 5 0.10 7.1e-08 -13.48 -12.2 4.3e-34 0.68 0.44 0.55 FALSE
23 GTEx Cells Transformed fibroblasts ICAM2 0.17 0.06 lasso 5 0.09 5.6e-07 4.52 -6.1 8.5e-10 0.29 0.94 0.00 FALSE
24 GTEx Colon Sigmoid CD79B 0.17 0.00 lasso 9 0.08 9.7e-04 12.91 9.2 2.8e-20 -0.23 0.09 0.08 FALSE
25 GTEx Colon Sigmoid CEP112 0.18 0.01 enet 22 0.02 5.0e-02 -8.63 6.9 5.0e-12 0.07 0.11 0.13 FALSE
26 GTEx Colon Transverse DDX42 0.19 0.07 lasso 4 0.11 4.4e-06 -0.22 -6.0 1.7e-09 -0.02 0.77 0.01 TRUE
27 GTEx Esophagus Mucosa PSMC5 0.11 0.09 lasso 4 0.14 1.1e-09 1.23 -7.4 1.8e-13 0.58 0.99 0.00 FALSE
28 GTEx Esophagus Mucosa CCDC47 0.12 0.00 lasso 5 0.00 3.7e-01 12.88 5.5 3.6e-08 -0.05 0.10 0.04 FALSE
29 GTEx Esophagus Mucosa DDX42 0.08 0.06 lasso 3 0.09 1.3e-06 12.91 -10.5 8.4e-26 0.19 0.96 0.00 FALSE
30 GTEx Esophagus Mucosa MAP3K3 0.05 0.01 enet 11 0.02 1.8e-02 8.97 10.6 4.7e-26 -0.29 0.29 0.03 FALSE
31 GTEx Esophagus Mucosa STRADA 0.05 0.07 lasso 2 0.05 1.9e-04 -13.57 -13.5 1.7e-41 0.74 0.23 0.28 TRUE
32 GTEx Esophagus Muscularis PSMC5 0.12 0.08 lasso 3 0.07 3.8e-05 -14.00 -13.0 1.2e-38 0.74 0.44 0.18 FALSE
33 GTEx Esophagus Muscularis DCAF7 0.08 0.06 lasso 7 0.05 6.7e-04 12.82 12.9 4.4e-38 -0.35 0.68 0.02 FALSE
34 GTEx Esophagus Muscularis MAP3K3 0.07 0.02 enet 8 0.02 3.0e-02 12.86 8.0 1.9e-15 -0.04 0.52 0.02 FALSE
35 GTEx Heart Atrial Appendage CYB561 0.19 0.01 enet 28 0.06 1.3e-03 -2.64 7.2 4.2e-13 -0.28 0.06 0.26 FALSE
36 GTEx Heart Atrial Appendage PRKCA 0.25 0.21 enet 13 0.25 1.2e-11 -8.63 8.1 8.5e-16 -0.01 0.01 0.99 TRUE
37 GTEx Heart Left Ventricle PRKCA 0.42 0.24 enet 40 0.26 4.0e-14 -8.63 7.7 1.9e-14 -0.02 0.01 0.99 FALSE
38 GTEx Lung PSMC5 0.04 0.00 enet 5 0.01 4.1e-02 1.23 -7.5 6.0e-14 0.59 0.35 0.05 FALSE
39 GTEx Lung TEX2 0.04 0.02 enet 13 0.01 5.0e-02 1.31 5.5 3.0e-08 -0.08 0.15 0.03 FALSE
40 GTEx Lung MAP3K3 0.07 0.07 lasso 2 0.06 2.8e-05 12.66 12.7 8.6e-37 -0.36 0.94 0.01 FALSE
41 GTEx Muscle Skeletal PSMC5 0.04 0.02 lasso 2 0.02 3.1e-03 9.07 5.2 1.9e-07 0.04 0.49 0.02 TRUE
42 GTEx Muscle Skeletal SMARCD2 0.13 0.03 lasso 5 0.04 1.3e-04 -13.48 -9.9 3.9e-23 0.59 0.78 0.08 FALSE
43 GTEx Nerve Tibial MAP3K3 0.07 0.10 lasso 2 0.08 4.1e-06 12.86 12.9 7.3e-38 -0.35 0.95 0.02 FALSE
44 GTEx Pancreas DDX42 0.17 0.18 lasso 3 0.16 3.6e-07 12.90 -10.4 2.3e-25 0.20 0.99 0.00 FALSE
45 GTEx Pancreas MAP3K3 0.10 0.08 lasso 4 0.07 9.0e-04 12.87 10.0 9.9e-24 -0.27 0.14 0.16 FALSE
46 GTEx Pituitary MAP3K3 0.11 0.07 lasso 6 0.04 3.5e-02 12.90 11.8 3.2e-32 -0.28 0.13 0.05 FALSE
47 GTEx Skin Not Sun Exposed Suprapubic MAP3K3 0.12 0.13 enet 10 0.15 1.8e-08 12.87 12.9 3.1e-38 -0.36 1.00 0.00 FALSE
48 GTEx Skin Sun Exposed Lower leg PSMC5 0.07 0.02 enet 23 0.02 1.6e-02 3.74 -7.8 5.7e-15 0.54 0.23 0.06 FALSE
49 GTEx Skin Sun Exposed Lower leg DDX42 0.07 0.04 lasso 4 0.05 2.5e-05 12.99 -10.6 2.8e-26 0.22 0.99 0.00 FALSE
50 GTEx Skin Sun Exposed Lower leg MAP3K3 0.08 0.08 lasso 3 0.08 6.8e-07 12.87 12.8 2.7e-37 -0.34 0.96 0.00 FALSE
51 GTEx Spleen FTSJ3 0.19 0.07 lasso 3 0.06 1.2e-02 11.66 7.5 7.8e-14 -0.03 0.35 0.10 FALSE
52 GTEx Spleen MAP3K3 0.21 0.14 lasso 10 0.10 1.4e-03 12.86 12.8 2.3e-37 -0.34 0.46 0.05 FALSE
53 GTEx Stomach DCAF7 0.24 0.00 enet 33 0.08 1.2e-04 4.64 11.7 1.0e-31 -0.18 0.08 0.04 FALSE
54 GTEx Testis PSMC5 0.14 0.13 lasso 6 0.14 6.0e-07 12.99 -13.1 5.2e-39 0.37 0.89 0.06 FALSE
55 GTEx Testis CCDC47 0.17 0.06 enet 28 0.09 1.0e-04 -13.93 8.9 8.0e-19 -0.68 0.02 0.97 FALSE
56 GTEx Testis TEX2 0.22 0.03 enet 17 0.06 1.3e-03 2.01 6.0 2.3e-09 -0.24 0.27 0.04 TRUE
57 GTEx Whole Blood CCDC47 0.05 0.00 lasso 5 0.01 9.8e-02 0.34 -8.3 1.2e-16 0.28 0.07 0.08 FALSE
58 METSIM Adipose CD79B 0.04 0.01 lasso 5 0.01 4.3e-03 -5.96 9.6 5.8e-22 -0.56 0.03 0.88 FALSE
59 METSIM Adipose RP11-214C8.2 0.03 0.00 blup 304 0.01 4.2e-03 -0.89 -7.0 2.3e-12 0.48 0.23 0.11 FALSE
60 NTR Blood LIMD2 0.04 0.03 blup 304 0.03 2.2e-10 12.81 -11.7 7.5e-32 0.42 1.00 0.00 FALSE
61 NTR Blood MAP3K3 0.02 0.01 lasso 2 0.01 2.0e-04 12.81 -13.3 2.3e-40 0.39 0.99 0.00 FALSE
62 YFS Blood AXIN2 0.20 0.05 enet 34 0.10 5.1e-31 6.80 -9.2 2.2e-20 0.01 1.00 0.00 TRUE
63 YFS Blood ICAM2 0.06 0.03 enet 21 0.04 1.3e-11 4.22 -7.3 2.6e-13 0.35 1.00 0.00 FALSE
64 YFS Blood LIMD2 0.03 0.03 enet 11 0.03 3.6e-11 11.50 -11.9 1.9e-32 0.42 1.00 0.00 FALSE
65 YFS Blood SMARCD2 0.03 0.04 lasso 7 0.05 7.6e-15 12.99 8.7 2.5e-18 -0.10 1.00 0.00 TRUE
66 The Cancer Genome Atlas Breast Invasive Carcinoma CD79B 0.02 0.02 lasso 2 0.01 3.0e-03 -15.96 15.7 3.3e-55 -0.99 0.00 0.94 FALSE
67 The Cancer Genome Atlas Breast Invasive Carcinoma SCN4A 0.04 0.01 blup 39 0.03 1.4e-07 -15.96 -14.5 1.0e-47 0.74 0.00 1.00 FALSE
68 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CSH2 0.09 0.01 blup 37 0.08 5.7e-05 1.32 7.4 1.5e-13 -0.66 0.42 0.25 FALSE
69 The Cancer Genome Atlas Colon Adenocarcinoma TCAM1P 0.05 0.03 blup 26 0.05 6.0e-04 2.65 7.6 2.4e-14 -0.63 0.03 0.79 FALSE
70 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma STRADA 0.05 0.03 lasso 1 0.02 1.7e-03 -13.48 -13.5 2.1e-41 0.75 0.00 0.89 FALSE
71 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DDX42 0.04 0.02 blup 51 0.03 3.9e-04 12.99 -7.9 3.5e-15 0.07 0.24 0.02 FALSE
72 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PRKCA 0.13 0.06 lasso 6 0.05 7.5e-06 5.36 5.4 6.9e-08 0.03 1.00 0.00 FALSE
73 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SCN4A 0.05 0.01 blup 41 0.04 2.2e-05 3.63 -10.2 3.1e-24 0.66 0.02 0.92 FALSE
74 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma STRADA 0.07 0.01 blup 57 0.03 5.5e-04 3.74 10.8 2.3e-27 -0.70 0.01 0.92 FALSE
75 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PSMC5 0.13 0.06 blup 27 0.07 7.2e-05 1.43 5.3 1.1e-07 0.09 0.40 0.02 TRUE
76 The Cancer Genome Atlas Brain Lower Grade Glioma DDX42 0.06 0.04 blup 51 0.06 7.9e-08 1.21 -6.3 2.1e-10 -0.05 0.99 0.00 FALSE
77 The Cancer Genome Atlas Brain Lower Grade Glioma SMARCD2 0.08 0.04 blup 28 0.04 5.1e-05 12.99 11.3 1.1e-29 -0.26 0.61 0.03 FALSE
78 The Cancer Genome Atlas Brain Lower Grade Glioma STRADA 0.03 0.00 blup 57 0.01 5.2e-02 -13.48 12.5 1.0e-35 -0.73 0.01 0.77 FALSE
79 The Cancer Genome Atlas Brain Lower Grade Glioma TCAM1P 0.02 0.03 blup 26 0.02 9.4e-04 1.55 7.7 1.7e-14 -0.62 0.02 0.63 FALSE
80 The Cancer Genome Atlas Lung Adenocarcinoma SMARCD2 0.04 0.02 blup 28 0.01 1.6e-02 12.88 10.6 2.1e-26 -0.21 0.02 0.04 FALSE
81 The Cancer Genome Atlas Pancreatic Adenocarcinoma FTSJ3 0.30 0.12 enet 10 0.18 6.7e-08 1.32 -6.1 1.0e-09 0.53 0.16 0.84 FALSE
82 The Cancer Genome Atlas Pancreatic Adenocarcinoma PSMC5 0.12 0.05 enet 19 0.07 6.2e-04 -13.93 -8.1 4.2e-16 0.53 0.01 0.86 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma DDX42 0.07 0.07 enet 11 0.07 9.2e-08 12.87 -9.5 3.1e-21 0.14 0.99 0.00 FALSE
84 The Cancer Genome Atlas Prostate Adenocarcinoma PSMC5 0.04 0.03 lasso 1 0.03 5.6e-04 -13.93 -13.9 4.0e-44 0.76 0.00 0.97 FALSE
85 The Cancer Genome Atlas Stomach Adenocarcinoma DDX42 0.04 0.02 blup 51 0.04 5.2e-04 12.93 -6.2 5.0e-10 -0.05 0.10 0.03 FALSE
86 The Cancer Genome Atlas Thyroid Carcinoma MAP3K3 0.02 0.02 blup 52 0.01 1.4e-02 12.66 11.8 3.6e-32 -0.27 0.07 0.06 FALSE
87 The Cancer Genome Atlas Thyroid Carcinoma SCN4A 0.04 0.01 blup 41 0.02 5.7e-03 3.63 -6.5 1.1e-10 0.21 0.02 0.04 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma TCAM1P 0.07 0.07 blup 26 0.08 2.8e-08 1.48 7.5 6.8e-14 -0.61 0.08 0.92 FALSE