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chr17:60,821,100-65,498,820

Best TWAS P=3.58e-62 · Best GWAS P=2.39e-57 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	12.87	12.4	4.3e-35	-0.49	0.69	0.11	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	13.11	10.0	2.1e-23	-0.24	0.78	0.02	TRUE
3	CommonMind	Brain Pre-frontal Cortex	TCAM1P	0.05	0.03	enet	8	0.04	4.1e-06	-13.44	7.4	1.6e-13	-0.62	0.83	0.16	FALSE
4	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-15.59	16.6	3.6e-62	-0.98	0.00	1.00	TRUE
5	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	12.93	12.5	4.9e-36	-0.34	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	-15.59	13.5	1.1e-41	-0.89	0.03	0.78	FALSE
7	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	12.88	12.6	1.1e-36	-0.34	0.31	0.08	FALSE
8	GTEx	Artery Tibial	DDX42	0.13	0.14	lasso	5	0.15	9.1e-12	12.88	-9.4	4.0e-21	0.13	1.00	0.00	FALSE
9	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	12.76	12.8	2.1e-37	-0.39	0.83	0.02	FALSE
10	GTEx	Brain Hypothalamus	DDX42	0.15	0.18	lasso	3	0.09	4.2e-03	13.11	-10.1	6.9e-24	0.21	0.14	0.06	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	12.86	-11.6	2.9e-31	0.33	0.20	0.05	FALSE
12	GTEx	Brain Putamen basal ganglia	DDX42	0.16	0.04	lasso	4	0.06	1.5e-02	-1.32	-5.2	2.3e-07	0.03	0.11	0.05	FALSE
13	GTEx	Breast Mammary Tissue	PSMC5	0.10	0.00	enet	24	0.00	4.5e-01	5.53	-6.7	1.7e-11	0.46	0.13	0.10	FALSE
14	GTEx	Breast Mammary Tissue	DCAF7	0.08	0.00	enet	18	0.05	1.1e-03	8.91	8.5	1.7e-17	-0.14	0.09	0.07	FALSE
15	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	12.87	13.0	1.6e-38	-0.36	0.95	0.00	FALSE
16	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	12.66	9.9	6.4e-23	-0.13	0.15	0.07	FALSE
17	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	-14.25	14.0	8.8e-45	-0.70	0.04	0.25	FALSE
18	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	11.50	11.6	2.4e-31	-0.29	0.07	0.06	FALSE
19	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	12.90	12.9	4.5e-38	-0.36	0.05	0.12	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	12.88	-12.9	5.8e-38	0.36	0.33	0.04	FALSE
21	GTEx	Cells Transformed fibroblasts	CD79B	0.20	0.00	lasso	4	0.00	4.3e-01	-1.97	-7.5	7.2e-14	0.32	0.11	0.08	FALSE
22	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	-13.48	-12.2	4.3e-34	0.68	0.44	0.55	FALSE
23	GTEx	Cells Transformed fibroblasts	ICAM2	0.17	0.06	lasso	5	0.09	5.6e-07	4.52	-6.1	8.5e-10	0.29	0.94	0.00	FALSE
24	GTEx	Colon Sigmoid	CD79B	0.17	0.00	lasso	9	0.08	9.7e-04	12.91	9.2	2.8e-20	-0.23	0.09	0.08	FALSE
25	GTEx	Colon Sigmoid	CEP112	0.18	0.01	enet	22	0.02	5.0e-02	-8.63	6.9	5.0e-12	0.07	0.11	0.13	FALSE
26	GTEx	Colon Transverse	DDX42	0.19	0.07	lasso	4	0.11	4.4e-06	-0.22	-6.0	1.7e-09	-0.02	0.77	0.01	TRUE
27	GTEx	Esophagus Mucosa	PSMC5	0.11	0.09	lasso	4	0.14	1.1e-09	1.23	-7.4	1.8e-13	0.58	0.99	0.00	FALSE
28	GTEx	Esophagus Mucosa	CCDC47	0.12	0.00	lasso	5	0.00	3.7e-01	12.88	5.5	3.6e-08	-0.05	0.10	0.04	FALSE
29	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	12.91	-10.5	8.4e-26	0.19	0.96	0.00	FALSE
30	GTEx	Esophagus Mucosa	MAP3K3	0.05	0.01	enet	11	0.02	1.8e-02	8.97	10.6	4.7e-26	-0.29	0.29	0.03	FALSE
31	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	-13.57	-13.5	1.7e-41	0.74	0.23	0.28	TRUE
32	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	-14.00	-13.0	1.2e-38	0.74	0.44	0.18	FALSE
33	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	12.82	12.9	4.4e-38	-0.35	0.68	0.02	FALSE
34	GTEx	Esophagus Muscularis	MAP3K3	0.07	0.02	enet	8	0.02	3.0e-02	12.86	8.0	1.9e-15	-0.04	0.52	0.02	FALSE
35	GTEx	Heart Atrial Appendage	CYB561	0.19	0.01	enet	28	0.06	1.3e-03	-2.64	7.2	4.2e-13	-0.28	0.06	0.26	FALSE
36	GTEx	Heart Atrial Appendage	PRKCA	0.25	0.21	enet	13	0.25	1.2e-11	-8.63	8.1	8.5e-16	-0.01	0.01	0.99	TRUE
37	GTEx	Heart Left Ventricle	PRKCA	0.42	0.24	enet	40	0.26	4.0e-14	-8.63	7.7	1.9e-14	-0.02	0.01	0.99	FALSE
38	GTEx	Lung	PSMC5	0.04	0.00	enet	5	0.01	4.1e-02	1.23	-7.5	6.0e-14	0.59	0.35	0.05	FALSE
39	GTEx	Lung	TEX2	0.04	0.02	enet	13	0.01	5.0e-02	1.31	5.5	3.0e-08	-0.08	0.15	0.03	FALSE
40	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	12.66	12.7	8.6e-37	-0.36	0.94	0.01	FALSE
41	GTEx	Muscle Skeletal	PSMC5	0.04	0.02	lasso	2	0.02	3.1e-03	9.07	5.2	1.9e-07	0.04	0.49	0.02	TRUE
42	GTEx	Muscle Skeletal	SMARCD2	0.13	0.03	lasso	5	0.04	1.3e-04	-13.48	-9.9	3.9e-23	0.59	0.78	0.08	FALSE
43	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	12.86	12.9	7.3e-38	-0.35	0.95	0.02	FALSE
44	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	12.90	-10.4	2.3e-25	0.20	0.99	0.00	FALSE
45	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	12.87	10.0	9.9e-24	-0.27	0.14	0.16	FALSE
46	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	12.90	11.8	3.2e-32	-0.28	0.13	0.05	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	12.87	12.9	3.1e-38	-0.36	1.00	0.00	FALSE
48	GTEx	Skin Sun Exposed Lower leg	PSMC5	0.07	0.02	enet	23	0.02	1.6e-02	3.74	-7.8	5.7e-15	0.54	0.23	0.06	FALSE
49	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	12.99	-10.6	2.8e-26	0.22	0.99	0.00	FALSE
50	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	12.87	12.8	2.7e-37	-0.34	0.96	0.00	FALSE
51	GTEx	Spleen	FTSJ3	0.19	0.07	lasso	3	0.06	1.2e-02	11.66	7.5	7.8e-14	-0.03	0.35	0.10	FALSE
52	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	12.86	12.8	2.3e-37	-0.34	0.46	0.05	FALSE
53	GTEx	Stomach	DCAF7	0.24	0.00	enet	33	0.08	1.2e-04	4.64	11.7	1.0e-31	-0.18	0.08	0.04	FALSE
54	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	12.99	-13.1	5.2e-39	0.37	0.89	0.06	FALSE
55	GTEx	Testis	CCDC47	0.17	0.06	enet	28	0.09	1.0e-04	-13.93	8.9	8.0e-19	-0.68	0.02	0.97	FALSE
56	GTEx	Testis	TEX2	0.22	0.03	enet	17	0.06	1.3e-03	2.01	6.0	2.3e-09	-0.24	0.27	0.04	TRUE
57	GTEx	Whole Blood	CCDC47	0.05	0.00	lasso	5	0.01	9.8e-02	0.34	-8.3	1.2e-16	0.28	0.07	0.08	FALSE
58	METSIM	Adipose	CD79B	0.04	0.01	lasso	5	0.01	4.3e-03	-5.96	9.6	5.8e-22	-0.56	0.03	0.88	FALSE
59	METSIM	Adipose	RP11-214C8.2	0.03	0.00	blup	304	0.01	4.2e-03	-0.89	-7.0	2.3e-12	0.48	0.23	0.11	FALSE
60	NTR	Blood	LIMD2	0.04	0.03	blup	304	0.03	2.2e-10	12.81	-11.7	7.5e-32	0.42	1.00	0.00	FALSE
61	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	12.81	-13.3	2.3e-40	0.39	0.99	0.00	FALSE
62	YFS	Blood	AXIN2	0.20	0.05	enet	34	0.10	5.1e-31	6.80	-9.2	2.2e-20	0.01	1.00	0.00	TRUE
63	YFS	Blood	ICAM2	0.06	0.03	enet	21	0.04	1.3e-11	4.22	-7.3	2.6e-13	0.35	1.00	0.00	FALSE
64	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	11.50	-11.9	1.9e-32	0.42	1.00	0.00	FALSE
65	YFS	Blood	SMARCD2	0.03	0.04	lasso	7	0.05	7.6e-15	12.99	8.7	2.5e-18	-0.10	1.00	0.00	TRUE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-15.96	15.7	3.3e-55	-0.99	0.00	0.94	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-15.96	-14.5	1.0e-47	0.74	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CSH2	0.09	0.01	blup	37	0.08	5.7e-05	1.32	7.4	1.5e-13	-0.66	0.42	0.25	FALSE
69	The Cancer Genome Atlas	Colon Adenocarcinoma	TCAM1P	0.05	0.03	blup	26	0.05	6.0e-04	2.65	7.6	2.4e-14	-0.63	0.03	0.79	FALSE
70	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	-13.48	-13.5	2.1e-41	0.75	0.00	0.89	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DDX42	0.04	0.02	blup	51	0.03	3.9e-04	12.99	-7.9	3.5e-15	0.07	0.24	0.02	FALSE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PRKCA	0.13	0.06	lasso	6	0.05	7.5e-06	5.36	5.4	6.9e-08	0.03	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SCN4A	0.05	0.01	blup	41	0.04	2.2e-05	3.63	-10.2	3.1e-24	0.66	0.02	0.92	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	3.74	10.8	2.3e-27	-0.70	0.01	0.92	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC5	0.13	0.06	blup	27	0.07	7.2e-05	1.43	5.3	1.1e-07	0.09	0.40	0.02	TRUE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	DDX42	0.06	0.04	blup	51	0.06	7.9e-08	1.21	-6.3	2.1e-10	-0.05	0.99	0.00	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	12.99	11.3	1.1e-29	-0.26	0.61	0.03	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	-13.48	12.5	1.0e-35	-0.73	0.01	0.77	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCAM1P	0.02	0.03	blup	26	0.02	9.4e-04	1.55	7.7	1.7e-14	-0.62	0.02	0.63	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	12.88	10.6	2.1e-26	-0.21	0.02	0.04	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FTSJ3	0.30	0.12	enet	10	0.18	6.7e-08	1.32	-6.1	1.0e-09	0.53	0.16	0.84	FALSE
82	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PSMC5	0.12	0.05	enet	19	0.07	6.2e-04	-13.93	-8.1	4.2e-16	0.53	0.01	0.86	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX42	0.07	0.07	enet	11	0.07	9.2e-08	12.87	-9.5	3.1e-21	0.14	0.99	0.00	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	-13.93	-13.9	4.0e-44	0.76	0.00	0.97	FALSE
85	The Cancer Genome Atlas	Stomach Adenocarcinoma	DDX42	0.04	0.02	blup	51	0.04	5.2e-04	12.93	-6.2	5.0e-10	-0.05	0.10	0.03	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	12.66	11.8	3.6e-32	-0.27	0.07	0.06	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	SCN4A	0.04	0.01	blup	41	0.02	5.7e-03	3.63	-6.5	1.1e-10	0.21	0.02	0.04	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	TCAM1P	0.07	0.07	blup	26	0.08	2.8e-08	1.48	7.5	6.8e-14	-0.61	0.08	0.92	FALSE