TWAS hub - ICAM2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1670	0.0600	5.9e-06	0.059	NA	0.061	NA	0.086	3.1e-05	NA	2.3e-05	NA	5.6e-07
2	METSIM	Adipose	0.1110	0.0370	2.9e-07	0.013	0.045	0.043	0.044	0.039	3.4e-03	2.4e-07	4.4e-07	3.2e-07	1.5e-06
3	YFS	Blood	0.0649	0.0203	3.7e-07	0.029	0.033	0.035	0.035	0.029	5.3e-10	5.1e-11	1.3e-11	1.5e-11	5.5e-10
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0325	0.0201	5.6e-03	0.004	-0.001	-0.002	NA	0.000	9.2e-02	3.8e-01	5.8e-01	NA	3.3e-01
5	TCGA	Lung Adenocarcinoma	0.0218	0.0120	7.6e-03	0.006	0.009	0.003	NA	0.008	5.9e-02	3.1e-02	1.1e-01	NA	3.1e-02
6	TCGA	Prostate Adenocarcinoma	0.0257	0.0141	3.9e-03	0.028	0.016	0.014	NA	0.014	5.8e-04	7.2e-03	1.1e-02	NA	1.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Forced vital capacity (FVC), Best measure	6.0	21.9	39.1	-5.9	-2.9	-6.2	-2.3	-3.9	-5.3
Forced expiratory volume in 1-second (FEV1), Best measure	5.8	18.4	31.2	-5.5	-2.5	-5.6	-2.3	-3.6	-5.0
Forced expiratory volume in 1-second (FEV1), predicted	5.5	11.5	22.7	-3.6	-2.0	-4.8	-3.1	-2.9	-3.3
Forced vital capacity (FVC)	5.1	19.6	39.4	-5.4	-2.3	-6.3	-2.3	-4.2	-4.5
Noisy workplace	4.3	5.3	7.9	2.8	2.2	2.5	0.9	2.2	2.7
Supplements: Vitamin C	4.3	5.0	9.3	-2.2	-1.9	-3.1	-2.0	-2.4	-1.7
Diabetes (father)	4.2	5.2	7.9	2.8	2.0	2.8	1.6	1.8	2.4
Hair/balding pattern: Pattern 4	4.2	10.2	14.7	-3.8	-3.8	-3.1	-1.8	-3.2	-2.9
Forced expiratory volume in 1-second (FEV1)	4.1	13.9	26.8	-4.5	-1.8	-5.2	-2.2	-3.2	-4.2
Hair/balding pattern: Pattern 3	4.0	5.9	16.2	2.6	4.0	1.0	1.3	2.3	2.1
Standing height	4.0	40.1	95.1	-8.0	-3.3	-9.8	-2.5	-5.6	-5.8
Comparative height size at age 10	3.9	21.5	50.7	-5.4	-2.4	-7.1	-2.0	-4.5	-4.3
Medication: Metformin	3.8	5.4	10.4	2.9	1.4	3.2	0.8	2.1	2.6
Depression (Nagel 2018)	3.7	5.6	9.7	2.4	2.0	3.1	1.6	2.4	2.4
Mouth/teeth dental problems	3.7	5.6	8.5	-2.4	-2.5	-2.7	-0.9	-2.9	-2.3
Sitting height	3.1	21.7	53.4	-6.1	-2.3	-7.3	-1.4	-4.2	-3.8
Cholesterol lowering medication	3.1	4.5	6.8	2.5	1.7	2.6	1.0	2.4	2.1
Primary Biliary Cirrhosis	3.0	4.2	9.5	1.2	1.3	3.1	2.7	2.2	0.9
Trunk predicted mass	3.0	17.0	45.0	-4.7	-3.1	-6.7	-1.9	-3.5	-3.0
Fasting Glucose	2.9	3.4	5.0	1.6	1.8	1.5	2.0	2.2	1.8
Trunk fat-free mass	2.9	16.5	43.4	-4.6	-3.1	-6.6	-1.9	-3.5	-3.0
Heart attack	2.8	3.5	4.7	1.9	2.0	2.2	2.1	1.0	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.8	5.8	10.4	-3.2	-1.8	-3.1	-1.3	-2.3	-2.2
Height	2.7	52.2	141.6	-9.1	-3.2	-11.9	-2.0	-6.4	-5.8
Frequency of depressed mood in last 2 weeks	2.7	3.8	7.3	2.3	1.1	1.6	1.6	1.8	2.7
Medication: Seretide 50 evohaler	2.7	3.1	5.4	2.1	0.9	2.3	1.5	1.6	1.8
Number of self-reported non-cancer illnesses	2.7	4.6	8.1	2.6	2.3	1.9	1.5	1.5	2.8
Frequency of tenseness / restlessness in last 2 weeks	2.6	4.0	8.0	2.4	1.2	2.8	1.0	2.1	1.8
Asthma	2.6	5.2	6.8	2.6	2.4	1.1	2.2	2.4	2.6
Medication: Blood pressure	2.6	4.6	8.5	2.0	2.0	2.7	1.1	2.9	1.7
Age started oral contraceptive pill	2.5	3.2	6.2	1.2	1.7	1.4	1.8	1.9	2.5
Eye problems/disorders: Glaucoma	2.4	2.8	5.0	-1.1	-1.7	-1.3	-1.9	-2.2	-1.6
Coronary Artery Disease (CAD)	2.3	2.8	7.8	1.4	2.8	1.6	0.0	1.2	1.7
Diabetes (self-reported)	2.3	3.6	6.4	2.5	1.3	2.5	0.8	1.3	2.1
Illnesses of father: Heart disease	2.3	3.2	5.2	1.4	2.3	2.0	1.4	2.0	1.5
Whole body fat-free mass	2.3	13.2	36.5	-4.0	-2.7	-6.0	-1.7	-3.1	-2.5
Mineral and other dietary supplements	2.3	3.1	4.8	1.9	2.1	2.2	0.1	2.0	1.3
Whole body water mass	2.3	13.1	36.2	-4.0	-2.8	-6.0	-1.8	-3.1	-2.5
Average weekly fortified wine intake	2.2	2.6	5.0	-1.6	-1.7	-0.6	-1.7	-1.4	-2.2
Heart attack/myocardial infarction (self-reported)	2.2	2.8	3.8	1.7	1.9	1.9	1.9	0.8	1.6
Had menopause	2.1	2.6	4.1	-1.9	-2.0	-1.4	-0.2	-2.0	-1.4
Leg fat percentage (right)	2.1	7.8	13.7	3.4	2.3	2.9	1.5	2.4	3.7
Multivitamins +/- minerals	2.0	2.5	4.0	-1.6	-2.0	-1.7	-0.6	-1.8	-1.5
Supplements: Glucosamine	2.0	2.6	3.8	-1.9	-1.9	-1.3	-0.6	-2.0	-1.6
Pain all over the body in last month	2.0	2.1	2.8	-1.6	-1.5	-1.6	-0.4	-1.7	-1.5
Medication: Amlodipine	2.0	2.8	4.9	1.5	1.6	2.2	1.1	2.1	1.2
Asthma (self-reported)	1.9	3.8	5.3	2.3	2.2	0.7	1.9	1.9	2.3
Leg fat percentage (left)	1.9	6.8	12.0	3.2	2.0	2.9	1.2	2.2	3.5
Mean Putamen Volume	1.8	2.1	5.6	1.1	1.8	0.2	2.4	0.3	1.6
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	5.5	-2.2	-0.7	-1.3	-0.0	-0.6	-2.3
Diabetes diagnosed by doctor	1.8	2.9	7.2	2.1	0.9	2.7	0.6	1.2	1.8
Medication: Gliclazide	1.8	2.0	3.0	1.6	1.2	1.7	1.2	1.4	1.3
Body fat percentage	1.7	6.6	11.6	3.0	2.4	2.5	1.6	2.1	3.4
Knee pain experienced in last month	1.7	2.6	7.1	-0.6	-1.5	-1.2	-2.7	-1.6	-1.3
Leg fat-free mass (right)	1.7	9.2	24.9	-3.1	-2.4	-5.0	-1.8	-2.6	-2.2
Leg predicted mass (right)	1.7	9.0	24.6	-3.1	-2.4	-5.0	-1.8	-2.6	-2.2
Type 2 Diabetes (T2D) (2012)	1.6	1.8	2.9	1.6	0.6	1.3	1.7	1.4	1.1
Trunk fat percentage	1.6	6.5	10.8	2.9	2.6	2.4	1.6	2.2	3.3
Number of live births	1.6	2.3	4.0	-1.8	-0.5	-1.5	-0.7	-1.9	-2.0
Arm fat-free mass (right)	1.6	8.2	23.9	-3.2	-2.1	-4.9	-1.3	-2.3	-1.9
Basal metabolic rate	1.6	8.6	26.5	-3.1	-2.0	-5.2	-1.4	-2.5	-1.8
Basal cell carcinoma (self-reported)	1.6	1.9	4.6	-1.6	-0.9	-2.1	-0.8	-1.3	-1.0
Leg fat-free mass (left)	1.5	7.8	23.8	-2.9	-1.9	-4.9	-1.5	-2.4	-1.8
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.1	1.4	1.4	1.2	1.4	0.3	1.4
Leg predicted mass (left)	1.5	8.1	24.4	-2.9	-2.0	-4.9	-1.5	-2.4	-1.8
Lupus	1.4	2.2	5.8	0.7	1.4	2.0	0.0	2.4	0.8
Diabetes (mother)	1.4	1.7	3.4	1.8	1.8	0.4	1.0	0.7	1.5
Had other major operations	1.4	1.8	4.2	-1.2	-0.4	-2.0	-0.4	-2.0	-0.8
Mouth/teeth dental problems: Dentures	1.4	2.4	4.0	1.4	1.0	1.5	1.3	1.9	2.0
Arm predicted mass (right)	1.4	7.0	19.9	-3.0	-2.0	-4.5	-1.1	-2.1	-1.8
Type 2 Diabetes (T2D) (2018)	1.3	2.5	4.7	2.2	0.7	2.1	0.4	1.4	1.8
Systolic blood pressure, automated reading	1.3	3.8	6.7	1.7	2.3	2.6	0.8	1.7	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	4.6	1.5	0.4	2.1	0.2	1.0	1.4
Arm fat percentage (right)	1.3	5.2	10.4	2.9	1.8	2.1	1.2	1.9	3.2
Pulse rate	1.3	2.2	5.2	1.9	2.3	1.6	0.3	1.2	0.5
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	5.5	-1.5	-1.0	-1.2	-0.9	-1.0	-2.3
Number of children fathered	1.3	1.4	3.4	-1.4	-0.7	-1.8	0.0	-1.0	-1.3
Pulse wave peak to peak time	1.3	1.6	3.1	-1.8	-1.3	-1.6	0.2	-1.0	-1.0
Age at last live birth	1.3	2.0	4.6	-1.8	-0.5	-2.1	0.6	-1.7	-0.8
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.9	-1.0	-0.8	-1.5	-1.7	-1.1	-1.0
Arm fat-free mass (left)	1.3	6.6	21.7	-2.7	-1.8	-4.7	-1.1	-2.1	-1.4
Supplements: Calcium	1.3	1.4	2.7	-1.3	-0.7	-1.6	-1.0	-1.0	-1.3
Arm predicted mass (left)	1.3	6.7	21.3	-2.7	-1.9	-4.6	-1.0	-2.2	-1.5
Age when periods started (menarche)	1.2	3.0	8.4	-1.6	-2.9	-0.5	-1.7	-1.0	-1.6
Peak expiratory flow (PEF)	1.2	2.7	9.4	-1.8	0.2	-3.1	-0.4	-1.0	-1.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.9	1.4	2.0	1.4	-0.2	1.3	0.5
Wheeze or whistling in the chest in last year	1.2	2.1	4.3	2.1	1.3	1.1	0.7	0.7	2.1
Medication: Omeprazole	1.2	1.4	2.7	1.4	0.6	1.5	-0.1	1.1	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.6	1.5	0.6	1.6	0.8	1.3	1.1
Illnesses of siblings: Diabetes	1.2	1.5	4.2	2.0	1.4	0.9	0.7	0.2	1.2
Arm fat percentage (left)	1.2	4.7	8.7	2.9	1.6	2.1	0.9	1.9	3.0
Ever had bowel cancer screening	1.2	1.4	3.1	-1.3	-1.3	0.1	-1.8	-0.5	-1.2
Osteoporosis (self-reported)	1.2	1.5	3.4	1.1	1.4	0.9	0.6	1.0	1.8
Ulcerative Colitis	1.1	1.6	3.4	1.1	1.3	1.1	0.0	1.8	1.5
Relative age of first facial hair	1.1	2.3	4.5	1.6	1.1	2.0	0.6	2.1	1.2
Medication for hormone replacement therapy	1.1	1.2	2.9	-1.0	-0.6	-1.5	-0.7	-1.7	-0.7
Hearing difficulty/problems with background noise	1.1	1.8	4.7	-0.8	-1.1	-1.2	-2.2	-1.3	-1.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.2	1.3	1.8	0.3	0.9	0.0	1.7
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	2.8	1.4	1.7	1.3	-0.4	1.5	1.2
Medication: Bendroflumethiazide	1.1	1.6	3.6	1.2	1.9	-0.2	1.2	1.1	1.5
Lung FVC	1.0	5.0	9.1	-3.0	-0.4	-2.6	-1.5	-1.7	-2.9
Vitamin and mineral supplements	1.0	1.3	2.0	1.2	1.3	1.4	0.4	1.4	0.9
Serious illness, injury or assault to yourself	1.0	1.2	3.2	1.8	1.1	1.3	-0.4	0.2	0.9
Body mass index (BMI)	1.0	4.2	8.7	2.9	1.1	1.8	0.9	1.8	3.0
Financial difficulties in last 2 years	1.0	1.4	3.4	1.8	0.9	0.9	0.2	0.1	1.8
Illnesses of mother	1.0	1.2	2.4	-1.4	-1.5	-1.3	-0.5	0.2	-1.0
Emphysema/chronic bronchitis	1.0	1.2	2.5	-1.6	-1.3	-1.2	-0.3	-1.0	-0.4
Migraine (self-reported)	1.0	1.3	2.5	-0.7	-1.6	-1.2	-0.6	-1.3	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.9	1.3	1.7	1.3	0.1	0.8	0.5
Long-standing illness, disability or infirmity	1.0	1.5	4.3	1.3	1.2	0.4	1.1	0.7	2.1
Medication for cholesterol	1.0	1.5	2.5	-1.6	-1.5	-0.8	-1.0	-1.0	-1.4
Reaction Time	0.9	1.7	3.2	1.4	1.8	1.5	1.2	0.9	0.9
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.1	-1.8	-1.2	-1.5	-1.1	-1.5	-1.7
Age at First Birth	0.9	1.3	4.1	1.0	2.0	-0.8	-0.6	-0.3	1.3
Body Mass Index (BMI) (2010)	0.9	1.3	4.3	-0.8	-2.1	-0.3	-0.8	-1.1	-0.8
Rheumatoid Arthritis	0.9	1.3	3.4	-0.6	-1.8	-0.0	-1.3	-0.9	-1.2
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.2	0.4	1.2	-0.7	0.6	0.5	1.8
Medication: Simvastatin	0.9	1.3	2.4	1.2	1.0	1.3	-0.9	1.6	0.5
Headache pain in last month	0.9	1.6	4.6	1.6	0.4	0.9	-0.4	1.1	2.1
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.6	1.2	0.6	1.2	1.0	0.9	1.2
Comparative body size at age 10	0.9	2.5	5.0	1.8	2.2	1.3	0.5	1.4	1.6
Medication: Allopurinol	0.9	1.2	2.6	-1.0	-1.2	-1.6	-1.1	-1.0	-0.0
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	-1.2	-1.4	-0.9	-0.8	-0.8	-0.8
Ever taken oral contraceptive pill	0.9	1.1	2.7	-1.6	-0.7	-0.8	0.6	-0.8	-1.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.6	-1.1	-1.6	-1.4	0.2	-1.1	-0.2
BMI	0.8	4.4	8.9	2.9	1.2	1.9	0.9	1.8	3.0
Number of treatments/medications taken	0.8	1.4	2.6	1.6	1.3	1.4	-0.1	1.1	1.2
Impedance of leg (right)	0.8	4.0	9.0	1.3	3.0	2.4	1.8	1.6	1.3
Relative age voice broke	0.8	1.3	3.5	-0.5	-1.9	0.7	-1.3	-0.1	-1.3
Qualifications: CSEs or equivalent	0.8	1.0	3.0	-0.1	-1.1	-0.4	-1.7	-0.9	-0.8
Impedance of leg (left)	0.8	3.7	7.8	1.3	2.5	2.8	1.6	1.6	1.1
Medication: Ramipril	0.8	1.0	2.8	1.1	0.6	1.7	-0.9	0.7	-0.2
Exposure to tobacco smoke outside home	0.8	1.1	3.0	-1.0	-0.7	-1.0	-0.7	-1.7	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.4	-0.8	-0.9	-0.8	-1.0	-1.6	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.9	-1.4	-1.3	-1.2	-0.1	-0.3	-0.4
Neck or shoulder pain in last month	0.8	1.1	3.0	1.1	0.6	1.2	0.5	0.8	1.7
Loneliness, isolation	0.8	1.1	2.5	0.9	0.5	1.1	0.8	1.6	0.9
Fractured/broken bones in last 5 years	0.8	1.1	2.2	1.4	1.5	0.1	0.1	0.9	1.3
Commuting to job workplace: Cycle	0.8	0.9	1.4	-1.1	-1.2	-1.1	0.6	-1.1	-0.2
Depressed Affect (Nagel 2018)	0.7	1.4	4.6	1.0	-0.1	2.1	-1.0	1.4	0.4
Neuroticism (Nagel 2018)	0.7	1.7	5.4	1.1	0.3	2.3	-0.9	1.4	0.9
Waist Hip Ratio (WHR)	0.7	3.3	9.7	1.8	1.8	3.1	-0.2	1.7	1.0
Systolic Blood Pressure	0.7	3.6	10.4	1.2	3.2	1.4	1.1	0.5	2.4
Severe depression (siblings)	0.7	0.8	1.7	0.9	1.3	-0.0	0.2	0.9	1.1
Prospective memory result	0.7	0.8	2.2	0.2	0.7	0.0	1.3	0.5	1.5
High blood pressure (siblings)	0.7	1.0	2.0	-0.8	-1.1	-1.2	-1.4	-0.2	-1.0
Health satisfaction	0.7	0.9	2.7	1.3	0.7	0.5	0.6	-0.0	1.6
Eye problems/disorders: None of the above	0.7	0.8	2.0	0.5	0.4	1.4	1.1	1.0	0.0
Overall health rating	0.7	1.5	4.1	2.0	0.8	1.0	0.4	0.4	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	3.2	0.3	1.8	0.7	0.4	0.8	0.3
Back pain experienced in last month	0.7	1.0	2.5	1.2	0.5	0.2	-1.6	-0.0	1.3
Myopia	0.7	1.0	2.5	-1.6	-1.1	-0.8	0.5	-0.9	-0.6
Schizophrenia (2018)	0.6	1.3	3.3	1.2	0.7	0.9	0.0	1.4	1.8
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	0.6	1.4	0.0	1.5	0.3	0.8
Prostate Cancer	0.6	0.8	1.5	0.9	-0.1	1.2	1.2	0.9	0.4
Taking other prescription medications	0.6	1.0	2.4	1.5	0.8	0.4	0.6	0.1	1.6
Medication: Atenolol	0.6	0.7	1.4	0.8	1.2	0.9	0.7	0.9	0.3
Illnesses of siblings	0.6	0.9	1.7	-1.0	-0.5	-0.7	0.9	-1.3	-0.9
Falls in the last year	0.6	0.8	2.0	-0.2	-1.3	-1.1	-0.2	-1.4	0.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	1.2	1.1	0.8	-0.6	0.5	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.8	0.4	0.4	0.3	1.7	-0.4	1.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	1.0	0.7	1.2	0.3	1.0	0.6
Mean time to correctly identify matches	0.6	1.1	2.6	0.6	1.2	1.6	1.3	0.4	0.6
Leg fat mass (right)	0.6	2.2	5.7	1.9	1.2	0.8	0.8	1.3	2.4
Pulse rate, automated reading	0.6	2.1	4.1	1.5	1.5	1.4	2.0	1.0	1.0
Medication: Paracetamol	0.6	0.9	1.9	1.4	-0.2	1.2	-0.3	0.4	1.3
Diastolic blood pressure, automated reading	0.6	1.9	5.8	1.1	2.4	1.0	1.1	0.8	1.3
Bipolar Disorder or Schizophrenia	0.5	1.3	3.8	1.1	1.1	0.3	0.0	1.3	2.0
Schizophrenia (2014)	0.5	1.1	2.6	0.9	1.0	0.8	0.0	1.6	1.4
Neuroticism	0.5	1.1	4.4	0.9	-0.3	2.1	-0.0	1.0	0.5
Fed-up feelings	0.5	1.0	3.3	0.3	-1.3	0.9	-1.8	0.1	0.1
Waist circumference	0.5	1.8	5.0	1.7	1.1	0.7	0.4	1.0	2.2
Alcohol usually taken with meals	0.5	0.8	3.9	-0.1	0.3	-0.3	2.0	0.8	-0.1
Time employed in main current job	0.5	0.5	1.5	-0.2	-1.2	0.3	-1.0	-0.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.5	-0.9	-0.1	-1.1	-0.6	-1.2	-0.2
Exposure to tobacco smoke at home	0.5	0.6	2.7	-0.1	-0.4	0.2	-1.7	0.1	-0.8
Breastfed as a baby	0.5	0.6	1.7	-1.0	0.1	-0.2	1.3	-0.4	-0.8
Tense / ‘highly strung’	0.5	0.8	1.6	0.4	-0.3	1.3	-0.1	1.3	1.0
Worry too long after embarrassment	0.5	0.8	3.3	1.0	0.7	1.8	-0.2	0.3	0.4
Shortness of breath walking on level ground	0.5	0.6	1.5	0.4	-0.7	-0.5	-1.2	-1.2	0.3
Eye problems/disorders: Cataract	0.5	0.6	1.2	-0.4	0.8	-0.8	0.8	-1.1	0.7
Breast cancer (self-reported)	0.5	0.7	2.2	-1.0	-0.4	-1.5	-0.3	-0.3	-0.5
Guilty feelings	0.5	0.8	2.0	0.0	-1.1	1.4	-1.2	0.2	0.0
Financial situation satisfaction	0.5	0.6	1.3	0.4	0.6	0.8	1.0	0.6	1.1
Medication: Atorvastatin	0.5	0.7	2.8	0.4	0.5	0.6	1.7	0.3	0.6
Risk taking	0.5	0.7	1.4	1.2	0.5	0.6	0.8	1.1	0.6
Ever depressed for a whole week	0.5	0.6	2.0	0.4	0.6	-0.3	1.4	0.0	0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	0.9	0.5	1.1	-0.4	0.6	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.9	-1.7	-0.6	-1.5	-0.7	-0.8	-1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	-0.8	-1.3	-0.1	0.0	-0.8	-0.6
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	0.1	1.0	-0.5	0.9	-0.6	0.4
Major Depression (MDD)	0.4	0.5	1.8	-0.6	-0.7	-0.8	0.0	-1.3	-0.1
Blood Red Count	0.4	3.8	11.8	0.7	1.5	0.5	3.4	1.2	2.5
Lung FEV1/FVC ratio	0.4	2.0	4.1	0.7	0.6	1.8	2.0	1.6	1.1
Hearing difficulty/problems: Yes	0.4	0.6	1.2	0.7	-0.2	1.0	-1.1	0.3	0.9
Angina	0.4	0.6	2.6	0.6	1.6	0.4	0.4	-0.3	0.3
Pack years adult smoking proportion	0.4	0.6	1.8	-0.2	-0.7	0.1	-1.4	-0.6	-0.8
Stomach or abdominal pain in last month	0.4	0.5	1.0	0.5	0.8	-0.7	0.6	0.3	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.3	1.1	1.0	0.9	1.1	0.5	0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	0.5	0.6	0.5	0.7	0.5	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.4	1.2	0.5	1.2	-0.0	0.1	0.8
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.1	-1.1	0.4	-1.0	-0.9	-0.3	-1.4
Medication: Cholesterol lowering	0.4	0.6	1.4	0.5	0.5	1.2	-0.7	1.1	0.2
Arm fat mass (right)	0.4	1.7	4.2	1.7	1.0	0.5	0.6	1.1	2.0
Medication: Paracetamol	0.4	0.6	1.5	0.8	-1.2	0.7	-0.6	-0.1	0.7
Angina (self-reported)	0.4	0.5	2.4	0.5	1.5	0.3	0.3	-0.1	0.0
Whole body fat mass	0.4	1.8	4.4	1.6	1.2	0.6	0.8	1.1	2.1
Chest pain or discomfort	0.4	0.6	0.9	0.9	1.0	0.3	0.4	-0.8	0.9
Leg pain on walking	0.4	0.5	1.3	1.0	0.6	-0.4	-0.5	0.4	1.2
Average weekly red wine intake	0.4	0.7	2.4	-0.9	-0.3	0.0	0.7	-0.3	-1.6
Qualifications: nursing, teaching	0.4	0.6	1.5	-0.7	0.2	-1.0	-0.9	0.2	-1.2
Average weekly champagne plus white wine intake	0.4	0.6	2.2	-1.5	-0.3	-1.0	-0.1	-0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.9	1.0	0.7	-0.2	-0.0	0.7
High cholesterol (Self-reported)	0.4	0.8	2.3	0.7	0.4	1.3	-0.3	1.5	0.2
Alcohol drinker status: Never	0.4	0.5	1.3	0.2	-0.0	1.2	-0.7	0.8	-0.5
Pain experienced in last month	0.4	0.6	1.5	-1.1	-0.7	0.2	0.6	0.2	-1.2
Leg fat mass (left)	0.4	1.6	4.4	1.7	0.8	0.7	0.6	1.0	2.1
Crohns Disease (2017)	0.3	0.7	1.8	-0.9	-0.9	-0.5	-0.2	-0.6	-1.4
HbA1C	0.3	0.3	1.1	0.4	-0.3	-0.6	-1.1	0.5	-0.2
Neuroticism (2016)	0.3	0.4	1.5	-0.5	-0.6	-0.6	0.0	-1.2	0.4
Triglycerides	0.3	0.6	1.1	-0.7	-1.0	-0.3	-0.8	-0.6	-0.9
Heel T-Score	0.3	2.4	6.7	1.6	0.6	1.1	1.8	0.1	2.6
Respiratory disease	0.3	0.6	1.2	0.9	0.9	0.1	0.8	1.1	0.6
Average weekly spirits intake	0.3	0.3	1.0	0.6	1.0	0.1	0.3	0.4	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.7	-0.1	-0.1	-0.1	1.3	-0.6	0.4
Supplements: Zinc	0.3	0.3	0.8	-0.5	-0.1	0.2	-0.9	-0.6	-0.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	-0.0	-0.3	-0.2	-0.2	-0.9	1.0
Medication: Levothyroxine sodium	0.3	0.5	1.6	1.0	1.3	-0.2	-0.6	0.2	-0.1
Trunk fat mass	0.3	1.4	3.9	1.3	1.3	0.2	0.7	0.9	2.0
Fluid intelligence score	0.3	0.6	1.5	-1.2	-0.1	-0.6	-0.5	-0.5	-1.1
Weight	0.3	1.5	7.2	-0.8	-0.4	-2.7	-0.4	-0.9	0.2
Hip circumference	0.3	1.4	4.4	0.7	0.8	-1.4	0.8	0.4	2.1
Alcohol intake versus 10 years previously	0.3	0.5	1.2	0.3	-0.7	1.0	1.1	0.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.3	-0.1	-0.1	0.5	1.1	0.5	0.7
Depression (self-reported)	0.3	0.4	1.4	0.2	0.8	0.5	0.2	0.3	1.2
Length of working week for main job	0.3	0.3	0.5	-0.7	-0.6	-0.5	-0.4	-0.7	-0.3
Pulse wave reflection index	0.3	0.3	0.9	0.0	0.0	-0.7	0.9	-0.4	0.7
Blood clot in the leg (DVT)	0.3	0.3	0.8	-0.7	-0.1	-0.9	0.4	-0.5	-0.5
Glaucoma (self-reported)	0.3	0.3	1.0	-0.3	-0.2	-0.9	-0.4	-1.0	-0.1
Gout (self-reported)	0.3	0.4	1.0	0.2	-0.2	-0.3	-1.0	0.1	1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.0	0.1	-0.9	-0.1	-0.4	0.0	-1.0
Medication for pain relief, constipation, heartburn	0.3	0.5	2.0	-0.7	-0.3	-1.4	-0.0	-0.4	-0.6
Heart disease (mother)	0.3	0.4	1.1	-0.2	-0.9	1.0	-0.2	-0.6	-0.1
Alcohol intake frequency.	0.3	0.6	2.0	-0.1	-1.4	-0.1	-1.0	-0.8	-0.3
Suffer from ‘nerves’	0.3	0.5	1.2	0.9	0.9	1.1	0.7	0.1	0.3
Medication: Aspirin	0.3	0.4	1.5	0.1	0.5	1.2	0.2	0.8	0.2
Smoking status: Previous	0.3	0.5	1.9	-0.7	0.0	-1.4	-0.1	-0.7	-0.1
Mood swings	0.3	0.6	2.0	-0.4	-1.4	0.4	-1.1	-0.2	-0.5
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.5	-0.3	-0.7	1.0	-0.3	-0.2
Medication: Aspirin	0.3	0.3	1.4	0.1	0.4	1.2	0.0	0.6	0.3
Arm fat mass (left)	0.3	1.3	3.6	1.6	0.9	0.3	0.6	0.9	1.9
Wears glasses or contact lenses	0.3	0.3	1.0	0.5	0.2	1.0	0.2	0.7	0.5
Hearing aid user	0.3	0.3	0.9	1.0	-0.0	0.6	0.6	0.2	0.5
Mother’s age at death	0.3	0.3	0.7	-0.3	0.1	-0.7	-0.9	-0.8	0.1
Number of operations (self-reported)	0.3	0.4	1.6	0.0	0.5	-0.7	-0.4	-1.3	-0.1
Alcohol drinker status: Previous	0.3	0.3	1.4	1.2	-0.1	0.7	0.1	-0.2	0.2
Pack years of smoking	0.3	0.4	0.9	-0.2	-0.8	0.2	-0.9	-0.4	-0.7
Impedance of whole body	0.3	1.7	5.5	0.6	2.3	1.7	0.9	0.8	0.5
Bipolar Disorder (2018)	0.2	0.4	0.8	0.4	0.9	-0.5	0.0	0.3	0.9
HDL Cholesterol	0.2	0.3	0.5	0.7	0.7	0.5	-0.1	-0.2	0.6
Chronotype (morning person)	0.2	0.5	0.9	0.4	0.8	-0.9	0.7	-0.2	0.7
Sensitivity / hurt feelings	0.2	0.3	0.9	0.0	0.1	-0.3	-1.0	-0.7	-0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.7	-0.4	-0.5	-0.4	0.1	-0.8	-0.5
Hand grip strength (right)	0.2	0.5	1.3	-0.7	0.3	-1.1	0.5	0.7	-0.4
Current tobacco smoking	0.2	0.3	1.2	0.3	0.4	1.1	0.3	0.2	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.1	0.2	-0.4	0.7	0.3	0.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.9	0.6	-0.2	0.6	-0.1	0.2
Number of incorrect matches in round	0.2	0.3	0.7	-0.2	-0.9	-0.5	-0.2	-0.6	0.1
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	0.4	-0.5	0.5	-0.0	0.1	0.9
Qualifications: None of the above	0.2	0.3	1.5	0.1	-0.2	0.0	0.7	-0.0	1.2
Allergy	0.2	0.5	1.1	-1.0	0.0	-0.5	-0.7	-0.4	-1.1
Neuroticism score	0.2	0.4	0.9	0.3	-0.6	1.0	-0.9	-0.0	0.0
Worrier / anxious feelings	0.2	0.4	1.3	-0.4	-0.3	-0.4	-1.1	-0.7	-0.3
Lung cancer (father)	0.2	0.3	1.4	0.1	-0.1	-0.3	-0.5	-1.2	-0.0
Birth weight of first child	0.2	0.4	0.6	-0.6	-0.7	-0.8	-0.2	-0.7	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.3	-0.2	-0.2	-1.1	0.2	-0.9	-0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	0.9	1.0	0.1	-0.9	0.2	-0.2
Qualifications: College or University degree	0.2	0.5	1.0	-0.4	0.9	-0.2	-0.5	0.9	-1.0
Family relationship satisfaction	0.2	0.3	1.2	0.1	0.3	-0.3	1.1	0.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.7	0.0	0.7	-0.2	-0.1	0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.7	0.4	-0.1	0.8	0.3	0.9	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.3	-0.5	0.3	0.6	-0.3	-0.6
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.7	0.2	0.5	0.1	-0.2	0.8
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.1	-0.5	-0.5	-0.6	-0.4	-0.3
Smoking status: Current	0.2	0.3	1.0	0.3	0.4	1.0	0.6	0.4	-0.1
Miserableness	0.2	0.3	0.6	-0.2	-0.7	0.1	-0.8	-0.4	-0.6
Medication: Blood pressure	0.2	0.4	1.3	0.7	1.1	0.3	0.5	0.4	0.5
Medication: Lisinopril	0.2	0.2	0.4	-0.6	0.3	-0.5	-0.4	-0.3	-0.6
Illnesses of father: High blood pressure	0.2	0.3	1.1	0.3	0.1	0.6	-0.5	1.0	0.2
Worry (Nagel 2018)	0.1	0.3	0.8	0.4	0.1	0.9	-0.3	0.8	0.4
Ulcerative Colitis (UC)	0.1	0.1	0.6	0.2	0.1	0.2	0.7	0.3	0.3
Breast Cancer	0.1	0.2	0.6	0.3	-0.1	0.8	-0.5	0.4	-0.1
Ovarian Cancer	0.1	0.1	0.5	0.0	-0.2	0.1	0.3	-0.3	-0.7
Bipolar Disorder (2011)	0.1	0.1	0.5	0.0	0.5	-0.7	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.2	0.5	0.1	0.2	0.3	0.4	0.7	-0.5
LDL Cholesterol	0.1	0.2	0.4	0.4	-0.7	0.1	0.2	-0.1	0.5
Blood Platelet Count	0.1	0.9	2.7	-0.5	-0.5	1.4	-1.6	-0.1	-0.6
Blood White Count	0.1	0.5	1.4	0.5	-0.1	1.2	0.7	0.0	1.1
Smoking Status	0.1	0.1	0.4	0.1	0.4	0.6	-0.1	0.5	0.2
Cardiovascular Disease	0.1	0.3	1.5	-0.1	0.0	0.1	-1.2	-0.0	0.2
Hypothyroidism (self reported)	0.1	0.3	1.0	0.6	1.0	0.0	-0.0	0.4	0.1
Tanning	0.1	1.0	2.9	1.2	1.7	0.7	0.2	0.8	0.8
Hand grip strength (left)	0.1	0.3	1.1	-0.2	0.3	-0.6	0.3	1.1	-0.4
Ever had hysterectomy (womb removed)	0.1	0.2	0.5	-0.6	-0.7	-0.0	0.2	-0.2	0.2
Medication: Co-codamol	0.1	0.2	0.4	-0.1	-0.2	0.6	-0.6	0.0	-0.5
Maternal smoking around birth	0.1	0.2	0.5	-0.0	-0.5	-0.6	0.3	-0.7	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	0.4	0.2	0.4	0.6	-0.0	0.2
High blood pressure	0.1	0.2	0.7	0.4	0.3	0.7	-0.8	0.0	-0.1
High blood pressure (mother)	0.1	0.2	0.8	0.0	0.9	-0.4	-0.2	-0.3	0.4
Past tobacco smoking	0.1	0.2	0.4	-0.1	-0.3	0.5	-0.6	0.1	-0.6
Nervous feelings	0.1	0.1	0.5	0.2	-0.1	0.2	0.2	-0.7	0.3
Impedance of arm (right)	0.1	0.7	3.0	0.2	1.7	0.7	0.7	0.1	0.1
Father’s age at death	0.1	0.1	0.7	0.1	-0.8	0.0	0.0	0.3	-0.2
Happiness	0.1	0.1	0.3	-0.3	-0.4	-0.6	-0.5	0.2	-0.2
Medication: Lansoprazole	0.1	0.1	0.2	-0.4	0.1	0.0	0.1	-0.5	0.4
Impedance of arm (left)	0.1	0.6	2.7	0.1	1.6	0.7	0.3	0.1	-0.2
Birth weight	0.1	0.1	0.4	0.3	0.1	0.6	-0.3	0.2	-0.2
Number of full brothers	0.1	0.1	0.3	0.4	-0.0	0.0	-0.3	-0.1	-0.5
Age at first live birth	0.1	0.2	0.9	-0.3	0.3	-0.9	0.6	0.2	0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.2	0.1	-0.5	0.2	-0.2	0.3
Medication: Ibuprofen	0.1	0.2	0.6	-0.1	0.8	0.1	-0.2	-0.2	0.5
Number of full sisters	0.1	0.1	0.6	-0.0	0.2	-0.3	-0.3	-0.8	0.0
Had major operations	0.1	0.2	0.7	0.3	0.8	-0.2	0.0	-0.2	-0.3
Hypertension (Self-reported)	0.1	0.4	1.4	0.3	0.4	0.7	-1.2	0.2	-0.3
Friendships satisfaction	0.1	0.1	0.3	-0.5	-0.2	-0.2	-0.0	-0.4	-0.2
Ever smoked	0.1	0.1	0.3	0.5	0.2	0.3	-0.2	0.5	0.5
Average weekly beer plus cider intake	0.1	0.1	0.4	0.2	-0.1	-0.2	-0.6	-0.4	-0.5
Irritability	0.1	0.2	0.5	-0.3	-0.4	0.4	-0.7	-0.3	-0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	0.1	0.4	0.1	0.7	0.1	0.1
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.0	0.1	-0.6	-0.2	-0.5	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.8	-0.7	-0.9	-0.9	0.1	-0.1	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.6	-0.2	0.3	-0.3	0.8	-0.1	0.1
Heart disease (siblings)	0.1	0.2	0.6	0.0	0.1	-0.3	-0.8	-0.1	0.5
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	-0.1	0.2	0.0	0.4	-0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.3	-0.2	-0.3	0.1	0.4	0.1	-0.5
Blood Eosinophil Count	0.0	0.2	1.1	-0.4	-1.1	-0.1	0.0	0.1	0.1
Allergy or Eczema	0.0	0.1	0.2	0.4	-0.0	-0.1	-0.5	-0.1	0.4
Hair Pigment	0.0	0.4	0.8	-0.8	-0.1	-0.9	0.1	-0.8	-0.1
Townsend deprivation index at recruitment	0.0	0.0	0.1	0.1	0.2	0.1	-0.4	0.1	-0.0
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.4	-0.1	0.5	-0.1	-0.2	0.1
Loud music exposure frequency	0.0	0.0	0.1	0.3	0.2	0.2	0.2	0.1	0.3
Commuting to job workplace: Public transport	0.0	0.1	0.1	0.1	0.3	0.3	-0.3	0.1	-0.3

Hub : Genes

ICAM2

Models

Trait associations