TWAS hub - CHSY3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.248	0.062	4.3e-11	0.172	NA	0.197	NA	0.198	6.1e-13	NA	1.0e-14	NA	8.2e-15
2	GTEx	Testis	0.203	0.058	3.8e-07	0.273	NA	0.246	NA	0.233	1.6e-12	NA	2.8e-11	NA	1.0e-10
3	TCGA	Thyroid Carcinoma	0.027	0.018	6.4e-03	0.023	0.02	0.003	NA	0.014	2.5e-03	0.0039	1.5e-01	NA	1.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Depression (self-reported)	7.6	9.1	11.4	2.8	-2.9	3.4
Ever highly irritable/argumentative for 2 days	6.0	7.3	10.2	2.8	-1.9	3.2
Chronotype (morning person)	5.9	13.6	19.5	-3.9	4.4	-2.4
Supplements: Fish oil (including cod liver oil)	5.7	7.4	12.5	3.5	-3.0	0.7
Multivitamins +/- minerals	5.1	6.5	10.1	2.4	-1.8	3.2
Chronic bronchitis/emphysema (father)	5.1	6.0	10.3	-2.4	3.2	-1.4
Frequency of depressed mood in last 2 weeks	4.8	6.8	9.3	2.1	-3.0	2.6
Neuroticism score	4.8	10.0	11.1	3.0	-3.2	3.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.5	5.2	6.6	2.6	-2.4	1.8
Ever depressed for a whole week	4.4	5.4	6.7	2.6	-2.5	1.9
Crohns Disease (2017)	4.3	9.4	20.0	2.5	-1.4	4.5
Medication for cholesterol	4.0	6.0	7.4	-2.7	2.5	-2.1
Medication for hormone replacement therapy	3.9	4.3	6.2	2.5	-2.4	1.0
Blood Eosinophil Count	3.8	28.9	49.3	-7.0	3.7	-4.9
Vitamin and mineral supplements	3.8	5.2	7.8	-2.0	2.0	-2.8
Neuroticism	3.7	9.0	13.0	2.7	-2.6	3.6
Seen a psychiatrist for nerves, anxiety, tension or depression	3.7	4.7	5.6	2.4	-2.0	2.2
Crohns Disease (2012)	3.6	5.7	10.2	2.3	-1.3	3.2
Leg pain on walking	3.6	4.6	5.7	2.4	-1.9	2.1
Mineral and other dietary supplements	3.6	4.9	7.3	-2.7	2.7	-0.3
Qualifications: CSEs or equivalent	3.5	4.6	5.2	2.3	-1.9	2.2
Depressed Affect (Nagel 2018)	3.4	7.1	13.6	1.9	-2.1	3.7
Sitting height	3.4	24.5	39.1	-4.7	6.2	-3.5
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.3	11.2	1.5	-1.5	3.4
Age at first live birth	3.3	5.8	8.3	-2.4	1.8	-2.9
Current tobacco smoking	3.2	5.2	6.9	2.4	-1.7	2.6
Number of full sisters	3.2	3.9	5.6	2.4	-1.4	2.0
Unable to work because of sickness or disability	3.2	4.1	7.3	1.8	-1.4	2.7
Irritable Bowel Disease (IBD)	3.0	7.2	15.4	2.2	-1.1	3.9
Eye problems/disorders: Cataract	3.0	3.5	4.0	-1.6	2.0	-1.9
Smoking status: Current	3.0	4.8	6.2	2.4	-1.6	2.5
Neuroticism (Nagel 2018)	2.9	6.9	11.4	1.9	-2.3	3.4
Falls in the last year	2.9	3.9	8.6	1.5	-1.0	2.9
Fed-up feelings	2.8	5.1	10.8	1.3	-1.6	3.3
Seen doctor (GP) for nerves, anxiety, tension or depression	2.8	4.3	10.0	1.5	-0.9	3.2
Fasting Glucose	2.7	3.2	6.5	1.5	-0.9	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.7	3.2	6.0	1.5	-2.4	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	8.3	0.9	-1.2	2.9
Stomach or abdominal pain in last month	2.6	3.2	5.3	1.7	-1.2	2.3
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	5.2	-1.4	1.5	-2.3
Prospective memory result	2.6	3.2	4.9	-2.0	2.2	-0.9
Family relationship satisfaction	2.6	3.2	4.4	2.0	-2.1	1.1
Supplements: Vitamin C	2.5	3.0	4.7	1.9	-2.2	0.9
Back pain experienced in last month	2.5	3.6	7.1	1.8	-0.8	2.7
Ever used hormone-replacement therapy (HRT)	2.4	3.1	4.6	2.1	-2.2	0.6
Supplements: Glucosamine	2.4	3.1	4.8	2.2	-2.0	0.7
Worry too long after embarrassment	2.4	4.0	5.9	2.4	-2.4	0.6
Commuting to job workplace: Walk	2.4	2.5	4.0	-2.0	1.7	-0.9
Depression (Nagel 2018)	2.3	3.4	4.5	1.5	-2.1	1.9
Sensitivity / hurt feelings	2.3	3.9	5.2	1.3	-2.3	2.2
Forced vital capacity (FVC), Best measure	2.3	8.2	14.5	-2.7	3.8	1.7
Chest pain or discomfort	2.2	3.2	6.6	1.4	-1.1	2.6
Guilty feelings	2.2	3.4	6.3	1.8	-2.5	0.8
Irritability	2.2	3.8	8.6	1.6	-0.6	2.9
High blood pressure (mother)	2.1	2.9	8.3	0.5	-0.5	2.9
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	4.7	-1.5	2.2	-0.9
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	2.8	1.7	-1.6	1.6
Exposure to tobacco smoke outside home	2.0	2.7	8.2	0.1	0.1	2.9
Average weekly spirits intake	1.9	2.3	3.5	1.9	-1.8	0.7
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	3.1	1.0	-1.3	1.8
Medication: Lansoprazole	1.9	2.2	2.8	1.2	-1.5	1.7
Standing height	1.9	18.6	40.3	-3.9	6.3	-0.6
Leg fat percentage (left)	1.9	6.7	8.4	2.6	-2.9	2.2
Alcohol usually taken with meals	1.8	3.0	5.0	2.2	-1.9	0.7
Financial difficulties in last 2 years	1.8	2.5	3.9	2.0	-1.4	1.2
Leg fat percentage (right)	1.8	6.5	8.5	2.7	-2.9	2.0
Number of full brothers	1.8	2.2	3.3	-1.8	1.8	0.3
Eye problems/disorders: None of the above	1.7	1.9	3.0	1.1	-1.7	1.3
Loneliness, isolation	1.7	2.3	5.1	0.5	-1.2	2.3
Qualifications: nursing, teaching	1.7	2.7	4.9	1.8	-2.2	0.3
Miserableness	1.7	3.0	6.8	0.8	-1.2	2.6
Breast Cancer	1.6	4.0	7.3	-1.5	1.5	-2.7
Arm fat percentage (left)	1.6	6.4	6.8	2.5	-2.6	2.4
Friendships satisfaction	1.6	2.0	4.8	0.6	-0.8	2.2
Cholesterol lowering medication	1.6	2.3	4.0	1.5	-0.9	2.0
Forced vital capacity (FVC)	1.5	5.6	10.9	-2.1	3.3	1.1
Pulse wave peak to peak time	1.5	1.8	2.6	-1.4	1.6	-0.9
Ever taken oral contraceptive pill	1.5	1.6	3.5	-1.9	1.1	-0.3
Height	1.4	26.1	61.8	-3.9	7.9	0.9
Smoking Status	1.4	3.3	3.8	1.7	-1.8	1.9
Angina	1.4	1.9	2.8	1.7	-1.0	1.4
Body mass index (BMI)	1.4	5.9	7.3	2.7	-2.4	2.1
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	5.3	-0.4	-0.1	-2.3
Arm fat percentage (right)	1.4	5.5	6.5	2.4	-2.5	2.1
Number of children fathered	1.4	1.6	1.7	1.3	-1.2	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.2	0.1	-0.7	-2.1
Shortness of breath walking on level ground	1.4	1.7	2.6	1.6	-1.1	1.2
Medication: Ibuprofen	1.4	1.7	2.0	1.4	-1.3	1.2
Age at last live birth	1.4	2.0	3.3	-1.0	1.3	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.4	1.2	-1.6	1.2
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.5	1.6	-1.2	1.0
Average weekly red wine intake	1.4	2.1	5.8	0.1	-0.7	-2.4
Medication: Bendroflumethiazide	1.4	2.1	3.4	-1.7	1.8	-0.2
Worry (Nagel 2018)	1.3	2.8	3.8	1.3	-1.6	2.0
BMI	1.3	7.3	9.1	3.0	-2.8	2.2
Relative age of first facial hair	1.3	2.7	5.4	-1.3	1.1	-2.3
Relative age voice broke	1.3	2.0	3.4	-1.8	1.5	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	2.6	1.1	-1.6	1.5
Had menopause	1.3	1.6	3.5	1.9	-1.1	0.0
Peak expiratory flow (PEF)	1.3	3.0	6.4	1.6	-0.5	2.5
Medication: Amlodipine	1.3	1.9	5.1	0.7	-0.2	2.3
Comparative height size at age 10	1.3	7.0	13.8	-2.3	3.7	1.4
Bipolar Disorder (2018)	1.2	2.0	2.6	-1.6	1.6	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	5.1	-1.2	2.3	2.1
Body fat percentage	1.2	4.8	5.4	2.2	-2.1	2.3
Mood swings	1.2	2.1	4.4	0.9	-1.0	2.1
Ulcerative Colitis (UC)	1.1	2.1	4.7	1.2	-0.4	2.2
Bipolar Disorder (2011)	1.1	1.1	1.4	-1.0	0.9	-1.2
Mouth/teeth dental problems	1.1	1.7	2.6	1.6	-1.6	0.3
Angina (self-reported)	1.1	1.5	2.5	1.6	-0.9	1.1
Illnesses of father: Heart disease	1.1	1.5	3.5	0.6	-0.8	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.8	-1.4	2.0	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	2.1	1.4	-1.1	-0.6
Number of operations (self-reported)	1.1	1.7	2.9	0.8	-1.2	1.7
Diastolic blood pressure, automated reading	1.1	3.3	5.1	1.9	-2.3	1.2
Lung FVC	1.0	5.1	7.1	-1.8	2.3	2.7
Hearing difficulty/problems: Yes	1.0	1.5	2.6	-1.4	0.3	-1.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.8	1.4	-0.8	1.0
Qualifications: None of the above	1.0	2.1	2.9	-1.7	1.7	0.7
Length of working week for main job	1.0	1.1	1.7	1.2	-1.3	0.5
Loud music exposure frequency	1.0	1.1	1.5	1.2	-0.8	1.1
Ovarian Cancer	0.9	1.2	1.3	-1.2	1.1	1.1
Prostate Cancer	0.9	1.2	1.7	1.2	-1.3	0.7
Medication: Atenolol	0.9	1.2	2.2	1.5	-1.1	-0.0
Hair/balding pattern: Pattern 3	0.9	1.4	3.3	-0.9	0.2	-1.8
Exposure to tobacco smoke at home	0.9	1.0	1.6	-0.6	1.1	1.3
Leg fat mass (right)	0.9	3.7	4.5	2.1	-1.7	1.9
Financial situation satisfaction	0.9	1.2	1.7	1.3	-1.1	0.7
Eye problems/disorders: Glaucoma	0.9	1.0	1.7	-0.8	0.8	-1.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.4	1.2	-1.1	0.5
Trunk fat percentage	0.8	3.2	5.3	1.6	-1.2	2.3
Serious illness, injury or assault to yourself	0.8	1.0	2.9	0.3	-0.0	1.7
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	3.9	-0.7	2.0	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.8	-0.0	-0.3	1.7
Medication: Cholesterol lowering	0.8	1.2	1.9	-0.9	1.4	-0.9
Hair/balding pattern: Pattern 4	0.8	2.0	4.8	0.7	-0.9	2.2
Birth weight of first child	0.8	1.4	1.8	1.3	-1.0	1.3
Gout (self-reported)	0.8	1.1	2.0	-1.1	1.4	-0.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.7	-0.6	0.7	-1.3
Neck or shoulder pain in last month	0.8	1.2	2.7	-0.7	0.7	1.6
Suffer from ‘nerves’	0.8	1.2	2.5	0.8	-0.7	1.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.4	-0.5	0.6	-1.6
Ever had bowel cancer screening	0.8	0.9	1.6	1.2	-1.0	0.3
Osteoporosis (self-reported)	0.8	1.0	2.2	-0.8	1.5	-0.3
Arm fat mass (left)	0.8	3.2	4.7	1.8	-1.4	2.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.4	0.9	-1.0	1.2
Illnesses of father: High blood pressure	0.8	1.0	1.9	-1.4	1.0	-0.1
Myopia	0.8	1.2	2.9	-0.5	0.6	-1.7
Leg fat mass (left)	0.8	3.0	3.5	1.9	-1.5	1.8
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	-1.4	0.4	-1.0
Schizophrenia (2014)	0.7	1.6	4.3	-0.4	0.6	-2.1
Tanning	0.7	8.4	10.6	2.8	-3.3	2.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.2	1.1	-1.1	0.5
Pulse wave Arterial Stiffness index	0.7	0.8	1.0	1.0	-1.0	0.6
Pulse wave reflection index	0.7	0.8	2.0	-0.6	0.2	1.4
High blood pressure (siblings)	0.7	1.0	1.2	-0.8	1.1	-1.1
Wheeze or whistling in the chest in last year	0.7	1.3	2.0	0.6	-1.4	1.2
Whole body fat mass	0.7	3.0	4.6	1.8	-1.1	2.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	1.6	-1.0	1.0	-1.3
Osteoarthritis (self-reported)	0.7	0.9	1.4	1.0	-1.2	-0.4
Average weekly beer plus cider intake	0.7	1.0	2.0	-0.7	0.8	-1.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	-1.2	0.8	0.7
Bipolar Disorder or Schizophrenia	0.6	1.4	2.7	-0.8	0.9	-1.6
Alzheimer’s Disease (in mother)	0.6	0.7	1.9	-1.4	0.4	-0.1
HbA1C	0.6	0.7	1.8	0.4	-0.2	1.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.0	-1.4	0.6	-1.1
Worrier / anxious feelings	0.6	1.2	1.6	1.1	-1.2	0.9
Happiness	0.6	0.7	1.0	0.8	-1.0	0.8
Arm fat mass (right)	0.6	2.3	3.2	1.6	-1.1	1.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	-1.1	1.0	-0.2
Blood clot in the leg (DVT)	0.6	0.8	1.9	0.6	0.3	1.4
Headache pain in last month	0.6	1.0	1.9	-1.4	1.0	0.2
Birth weight	0.6	1.3	2.4	1.6	-0.9	0.9
Health satisfaction	0.6	0.8	1.7	0.9	-0.1	1.3
Knee pain experienced in last month	0.6	0.9	2.2	0.8	-0.2	1.5
Pain experienced in last month	0.6	1.0	2.3	0.2	-0.8	-1.5
Reaction Time	0.5	0.9	1.2	-1.0	0.8	1.1
LDL Cholesterol	0.5	0.9	2.3	0.0	-0.6	-1.5
Blood Platelet Count	0.5	5.6	10.0	-3.2	2.5	0.6
Waist Hip Ratio (WHR)	0.5	2.2	2.7	1.6	-1.1	1.6
Lung FEV1/FVC ratio	0.5	2.5	5.1	2.3	-1.5	0.3
Severe depression (siblings)	0.5	0.5	1.6	-0.1	0.2	1.3
Impedance of leg (right)	0.5	2.5	4.2	-2.0	1.7	-0.8
Maternal smoking around birth	0.5	0.7	2.0	0.3	0.3	1.4
Trunk fat mass	0.5	2.2	4.5	1.3	-0.5	2.1
Hearing difficulty/problems with background noise	0.5	0.8	1.4	-1.2	0.7	-0.6
Allergy	0.5	1.2	2.8	1.7	-0.9	0.1
Number of live births	0.5	0.8	1.7	1.3	-0.3	0.7
Pulse rate	0.5	0.8	1.6	0.4	-0.7	-1.3
Trunk predicted mass	0.5	2.6	6.7	-1.0	2.6	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.3	-0.7	-0.5	-1.1
Emphysema/chronic bronchitis	0.5	0.6	1.0	1.0	-0.7	0.5
Pulse rate, automated reading	0.5	1.5	4.2	-0.5	-0.1	-2.1
Long-standing illness, disability or infirmity	0.5	0.8	2.4	-0.1	-0.2	1.6
Asthma (self-reported)	0.5	0.9	2.4	-1.6	0.4	-0.4
Illnesses of father: None of the above (group 1)	0.5	0.7	1.9	0.2	-0.2	1.4
Wears glasses or contact lenses	0.5	0.6	1.5	-0.5	0.3	-1.2
Medication: Paracetamol	0.5	0.8	1.1	-1.0	0.5	-1.1
Alcohol drinker status: Never	0.5	0.6	0.7	-0.7	0.8	-0.8
Impedance of whole body	0.5	2.6	4.6	-2.1	1.7	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	0.6	-0.9	-0.5
Coronary Artery Disease (CAD)	0.4	0.5	1.0	-0.4	1.0	-0.4
Neuroticism (2016)	0.4	0.5	1.1	0.4	-1.0	0.6
Rheumatoid Arthritis	0.4	0.6	1.6	-0.4	1.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.1	-0.8	1.1	-0.7
Medication: Co-codamol	0.4	0.5	1.2	0.2	-0.5	-1.1
Diabetes (father)	0.4	0.5	1.2	1.1	-0.6	0.0
Hand grip strength (right)	0.4	1.2	2.1	-0.5	1.1	1.5
Impedance of leg (left)	0.4	2.1	4.0	-2.0	1.5	-0.6
Waist circumference	0.4	1.6	2.9	1.7	-0.8	1.2
Pain all over the body in last month	0.4	0.4	0.8	-0.6	0.9	0.0
Illnesses of siblings	0.4	0.5	0.9	0.3	-0.8	0.9
Trunk fat-free mass	0.4	2.4	6.4	-1.0	2.5	0.2
Asthma	0.4	0.7	1.9	-1.4	0.1	-0.5
Illnesses of mother	0.4	0.4	1.2	-0.3	0.1	-1.1
Glaucoma (self-reported)	0.4	0.5	1.3	-0.2	0.3	-1.2
Smoking status: Previous	0.4	0.6	1.2	-1.1	0.3	-0.6
Medication: Aspirin	0.4	0.5	0.9	0.9	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.3	0.2	-0.2	1.5
Ever smoked	0.4	0.8	1.2	0.6	-0.9	1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.4	0.5	0.3	1.2
Schizophrenia (2018)	0.3	0.6	1.8	0.2	-0.1	-1.3
Major Depression (MDD)	0.3	0.3	0.4	0.6	-0.5	-0.6
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.6	-0.6	1.3	0.4
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.9	-0.5	0.0
Ulcerative Colitis	0.3	0.4	1.1	0.2	0.1	1.0
Respiratory disease	0.3	0.8	2.3	-1.5	0.1	0.1
Hair Pigment	0.3	9.0	11.1	-3.0	2.6	-3.3
Hand grip strength (left)	0.3	0.9	2.2	0.2	0.6	1.5
Systolic blood pressure, automated reading	0.3	0.9	1.7	1.3	-1.0	-0.1
Average weekly fortified wine intake	0.3	0.4	0.8	0.5	-0.9	0.3
Had other major operations	0.3	0.4	0.6	0.8	-0.5	0.5
Diabetes (self-reported)	0.3	0.5	1.4	-0.3	-0.1	-1.2
Weight	0.3	1.4	3.2	1.0	0.4	1.8
Impedance of arm (right)	0.3	1.4	2.2	-1.5	1.3	-0.5
Noisy workplace	0.3	0.4	0.6	0.7	-0.5	0.6
Mouth/teeth dental problems: Dentures	0.3	0.5	1.3	-0.2	0.3	1.1
Impedance of arm (left)	0.3	1.3	2.3	-1.5	1.2	0.1
Breastfed as a baby	0.3	0.3	0.6	0.8	-0.5	0.1
Arm fat-free mass (right)	0.3	1.6	4.2	-0.5	2.1	0.6
Migraine (self-reported)	0.3	0.4	0.7	0.2	-0.9	0.7
Medication: Seretide 50 evohaler	0.3	0.4	0.8	-0.5	-0.2	-0.9
Mean time to correctly identify matches	0.3	0.6	0.9	-0.9	0.8	0.4
Heart disease (mother)	0.3	0.3	0.8	0.5	-0.1	-0.9
Arm predicted mass (right)	0.3	1.4	3.3	-0.4	1.8	0.8
Alcohol intake frequency.	0.3	0.6	1.0	-0.8	1.0	-0.5
Overall health rating	0.3	0.8	1.9	0.5	-0.2	1.4
Whole body fat-free mass	0.3	1.8	4.9	-0.5	2.2	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	0.5	-1.0	-0.0
Diabetes diagnosed by doctor	0.3	0.5	0.7	-0.8	0.5	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	-0.6	0.7	-0.4
Breast cancer (self-reported)	0.3	0.4	0.7	0.6	0.1	-0.9
Whole body water mass	0.3	1.9	5.1	-0.5	2.2	0.7
Hearing aid user	0.3	0.3	0.7	-0.3	-0.9	-0.3
Basal metabolic rate	0.3	1.4	3.3	-0.2	1.8	0.9
Risk taking	0.3	0.4	0.7	0.8	0.1	0.8
Age started oral contraceptive pill	0.3	0.4	0.6	0.7	-0.7	0.1
Heart disease (siblings)	0.3	0.3	0.7	-0.0	0.9	-0.5
Age at First Birth	0.2	0.3	0.6	0.8	-0.4	-0.0
HDL Cholesterol	0.2	0.4	0.9	0.0	-0.4	-1.0
Lupus	0.2	0.4	0.6	0.8	-0.5	-0.5
Triglycerides	0.2	0.3	0.4	-0.5	0.6	-0.5
Blood White Count	0.2	1.5	2.7	-1.4	0.1	-1.6
Number of treatments/medications taken	0.2	0.3	0.5	0.3	-0.6	0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	-0.4	0.4	-0.4
Medication: Metformin	0.2	0.3	0.4	0.7	-0.6	0.1
Pack years adult smoking proportion	0.2	0.3	0.6	0.8	-0.4	-0.4
Leg fat-free mass (left)	0.2	1.2	1.8	0.3	1.3	1.3
Medication: Levothyroxine sodium	0.2	0.4	0.5	0.7	-0.4	-0.7
Leg predicted mass (left)	0.2	1.3	2.0	0.3	1.3	1.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	0.6	0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	-0.5	-0.1	-1.1
Medication: Simvastatin	0.2	0.3	0.8	0.2	0.1	0.9
Time employed in main current job	0.2	0.2	0.5	0.7	-0.3	0.4
Alcohol intake versus 10 years previously	0.2	0.4	0.6	0.3	-0.7	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.7	-0.8	0.8	0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.7	-0.2	0.8	0.3
Medication: Paracetamol	0.2	0.3	0.6	-0.5	0.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.5	0.6	-0.4	-0.7
Comparative body size at age 10	0.2	0.5	0.7	0.5	-0.8	0.7
Qualifications: College or University degree	0.2	0.7	2.2	0.1	0.1	-1.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.4	-0.3	0.6	0.5
Medication: Allopurinol	0.2	0.3	0.7	-0.3	0.8	0.2
Medication: Omeprazole	0.2	0.2	0.5	0.4	0.1	0.7
Had major operations	0.2	0.2	0.6	0.1	-0.3	0.7
Medication: Aspirin	0.2	0.2	0.4	0.6	0.0	0.6
Leg fat-free mass (right)	0.2	1.3	2.1	0.3	1.2	1.5
Medication: Gliclazide	0.2	0.2	0.4	0.4	-0.6	-0.0
Leg predicted mass (right)	0.2	1.2	2.1	0.3	1.2	1.4
Arm fat-free mass (left)	0.2	1.2	3.3	-0.4	1.8	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	-0.6	0.5	-1.1
Basal cell carcinoma (self-reported)	0.2	0.3	0.4	0.6	0.1	0.6
Pack years of smoking	0.2	0.4	0.7	0.6	-0.3	-0.8
Arm predicted mass (left)	0.2	0.9	2.2	0.0	1.5	0.8
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	0.2	-0.3	1.0
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.0	0.3	-0.6
Mean Putamen Volume	0.1	0.1	0.1	0.3	0.2	-0.3
Blood Red Count	0.1	1.3	3.1	1.8	-0.9	0.0
Heel T-Score	0.1	0.7	1.8	-0.1	-0.5	1.4
Cardiovascular Disease	0.1	0.2	0.4	-0.6	0.1	-0.4
Hypothyroidism (self reported)	0.1	0.2	0.4	0.1	0.3	-0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.1	0.4	-0.4
Supplements: Zinc	0.1	0.1	0.2	0.2	-0.5	-0.1
Diabetes (mother)	0.1	0.2	0.3	-0.3	0.5	0.4
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.1	-0.7	0.1
Taking other prescription medications	0.1	0.1	0.2	-0.2	0.0	0.5
Age when periods started (menarche)	0.1	0.3	0.7	0.8	-0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.7	-0.2	-0.1	-0.8
High blood pressure	0.1	0.3	0.6	0.5	-0.8	0.4
Past tobacco smoking	0.1	0.1	0.3	0.1	0.5	-0.3
Nervous feelings	0.1	0.2	0.4	0.1	-0.1	-0.7
Medication: Ramipril	0.1	0.2	0.4	-0.4	-0.1	0.7
Fluid intelligence score	0.1	0.2	0.3	-0.6	0.4	0.3
Hip circumference	0.1	0.3	0.7	-0.0	0.6	0.8
Father’s age at death	0.1	0.2	0.3	0.1	-0.5	0.5
Lung cancer (father)	0.1	0.1	0.3	-0.2	0.5	0.1
Tense / ‘highly strung’	0.1	0.2	0.3	0.3	-0.2	0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.5	-0.4	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.7	0.2	-0.3
Hypertension (Self-reported)	0.1	0.2	0.5	0.3	-0.7	0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.0	0.3	0.6
Mother’s age at death	0.1	0.1	0.2	0.0	-0.4	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.1	-0.5	0.2
Commuting to job workplace: Public transport	0.1	0.2	0.4	0.3	0.1	0.6
Medication: Blood pressure	0.1	0.2	0.3	0.4	-0.5	0.5
High cholesterol (Self-reported)	0.1	0.3	0.3	0.5	-0.5	0.6
Medication: Lisinopril	0.1	0.1	0.3	0.2	-0.6	-0.1
Medication: Atorvastatin	0.1	0.1	0.2	0.4	-0.3	-0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.1	0.3	0.2	-0.3
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.1	0.3	-0.5
Supplements: Calcium	0.1	0.2	0.3	0.4	0.0	0.6
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.0	0.5	0.1
Primary Biliary Cirrhosis	0.0	0.1	0.1	-0.1	0.3	-0.2
Systolic Blood Pressure	0.0	0.1	0.2	0.4	-0.3	-0.2
Allergy or Eczema	0.0	0.1	0.2	-0.2	-0.4	0.1
Number of incorrect matches in round	0.0	0.0	0.1	0.1	0.1	0.3
Heart attack	0.0	0.0	0.0	0.2	0.0	-0.2
Medication: Blood pressure	0.0	0.1	0.1	-0.4	-0.0	0.3
Illnesses of siblings: Diabetes	0.0	0.0	0.0	-0.1	0.1	0.2
Number of self-reported non-cancer illnesses	0.0	0.1	0.1	-0.4	0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.1	0.1	0.3	0.1	0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.1	0.0	-0.4

Hub : Genes

CHSY3

Models

Trait associations