Hub : Genes

CHSY3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.248 0.062 4.3e-11 0.172 NA 0.197 NA 0.198 6.1e-13 NA 1.0e-14 NA 8.2e-15
2 GTEx Testis 0.203 0.058 3.8e-07 0.273 NA 0.246 NA 0.233 1.6e-12 NA 2.8e-11 NA 1.0e-10
3 TCGA Thyroid Carcinoma 0.027 0.018 6.4e-03 0.023 0.02 0.003 NA 0.014 2.5e-03 0.0039 1.5e-01 NA 1.5e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.2 2.0 2.6 -1.6 1.6 -0.9
Bipolar Disorder or Schizophrenia 0.6 1.4 2.7 -0.8 0.9 -1.6
Depressed Affect (Nagel 2018) 3.4 7.1 13.6 1.9 -2.1 3.7
Depression (Nagel 2018) 2.3 3.4 4.5 1.5 -2.1 1.9
Intelligence (Savage-Jansen 2018) 0.1 0.4 0.9 0.2 -0.3 1.0
Neuroticism (Nagel 2018) 2.9 6.9 11.4 1.9 -2.3 3.4
Schizophrenia (2018) 0.3 0.6 1.8 0.2 -0.1 -1.3
Schizophrenia vs Biploar Disorder 0.4 0.5 0.9 0.6 -0.9 -0.5
Worry (Nagel 2018) 1.3 2.8 3.8 1.3 -1.6 2.0
Alzheimer’s Disease (in mother) 0.6 0.7 1.9 -1.4 0.4 -0.1
Alzheimer’s Disease (in father) 0.1 0.1 0.3 -0.0 0.3 -0.6
Alzheimer’s Disease (including proxy) 0.7 1.0 1.8 -1.4 0.4 -1.0
Crohns Disease (2017) 4.3 9.4 20.0 2.5 -1.4 4.5
Irritable Bowel Disease (IBD) 3.0 7.2 15.4 2.2 -1.1 3.9
Ulcerative Colitis (UC) 1.1 2.1 4.7 1.2 -0.4 2.2
Major Depression (MDD) 0.3 0.3 0.4 0.6 -0.5 -0.6
Reaction Time 0.5 0.9 1.2 -1.0 0.8 1.1
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.6 -0.6 1.3 0.4
Breast Cancer 1.6 4.0 7.3 -1.5 1.5 -2.7
Ovarian Cancer 0.9 1.2 1.3 -1.2 1.1 1.1
Prostate Cancer 0.9 1.2 1.7 1.2 -1.3 0.7
Age at First Birth 0.2 0.3 0.6 0.8 -0.4 -0.0
Bipolar Disorder (2011) 1.1 1.1 1.4 -1.0 0.9 -1.2
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 0.9 -0.5 0.0
Coronary Artery Disease (CAD) 0.4 0.5 1.0 -0.4 1.0 -0.4
Crohns Disease (2012) 3.6 5.7 10.2 2.3 -1.3 3.2
Mean Putamen Volume 0.1 0.1 0.1 0.3 0.2 -0.3
Fasting Glucose 2.7 3.2 6.5 1.5 -0.9 2.6
HbA1C 0.6 0.7 1.8 0.4 -0.2 1.3
HDL Cholesterol 0.2 0.4 0.9 0.0 -0.4 -1.0
LDL Cholesterol 0.5 0.9 2.3 0.0 -0.6 -1.5
Lupus 0.2 0.4 0.6 0.8 -0.5 -0.5
Neuroticism (2016) 0.4 0.5 1.1 0.4 -1.0 0.6
Primary Biliary Cirrhosis 0.0 0.1 0.1 -0.1 0.3 -0.2
Rheumatoid Arthritis 0.4 0.6 1.6 -0.4 1.2 -0.1
Schizophrenia (2014) 0.7 1.6 4.3 -0.4 0.6 -2.1
Triglycerides 0.2 0.3 0.4 -0.5 0.6 -0.5
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.4 1.2 -1.1 0.5
Ulcerative Colitis 0.3 0.4 1.1 0.2 0.1 1.0
Blood Eosinophil Count 3.8 28.9 49.3 -7.0 3.7 -4.9
Blood Platelet Count 0.5 5.6 10.0 -3.2 2.5 0.6
Blood Red Count 0.1 1.3 3.1 1.8 -0.9 0.0
Blood White Count 0.2 1.5 2.7 -1.4 0.1 -1.6
Heel T-Score 0.1 0.7 1.8 -0.1 -0.5 1.4
BMI 1.3 7.3 9.1 3.0 -2.8 2.2
Height 1.4 26.1 61.8 -3.9 7.9 0.9
Waist Hip Ratio (WHR) 0.5 2.2 2.7 1.6 -1.1 1.6
Systolic Blood Pressure 0.0 0.1 0.2 0.4 -0.3 -0.2
Smoking Status 1.4 3.3 3.8 1.7 -1.8 1.9
Allergy or Eczema 0.0 0.1 0.2 -0.2 -0.4 0.1
Cardiovascular Disease 0.1 0.2 0.4 -0.6 0.1 -0.4
Hypothyroidism (self reported) 0.1 0.2 0.4 0.1 0.3 -0.6
Respiratory disease 0.3 0.8 2.3 -1.5 0.1 0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.1 -0.8 1.1 -0.7
Lung FEV1/FVC ratio 0.5 2.5 5.1 2.3 -1.5 0.3
Lung FVC 1.0 5.1 7.1 -1.8 2.3 2.7
Neuroticism 3.7 9.0 13.0 2.7 -2.6 3.6
Chronotype (morning person) 5.9 13.6 19.5 -3.9 4.4 -2.4
Hair Pigment 0.3 9.0 11.1 -3.0 2.6 -3.3
Tanning 0.7 8.4 10.6 2.8 -3.3 2.5
Hand grip strength (left) 0.3 0.9 2.2 0.2 0.6 1.5
Number of treatments/medications taken 0.2 0.3 0.5 0.3 -0.6 0.7
Average weekly spirits intake 1.9 2.3 3.5 1.9 -1.8 0.7
Sensitivity / hurt feelings 2.3 3.9 5.2 1.3 -2.3 2.2
Frequency of depressed mood in last 2 weeks 4.8 6.8 9.3 2.1 -3.0 2.6
Hearing difficulty/problems: Yes 1.0 1.5 2.6 -1.4 0.3 -1.6
Relative age of first facial hair 1.3 2.7 5.4 -1.3 1.1 -2.3
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 4.7 -1.5 2.2 -0.9
Ever used hormone-replacement therapy (HRT) 2.4 3.1 4.6 2.1 -2.2 0.6
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 -0.1 0.4 -0.4
Systolic blood pressure, automated reading 0.3 0.9 1.7 1.3 -1.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.2 -0.4 0.4 -0.4
Angina 1.4 1.9 2.8 1.7 -1.0 1.4
Medication for hormone replacement therapy 3.9 4.3 6.2 2.5 -2.4 1.0
Vitamin and mineral supplements 3.8 5.2 7.8 -2.0 2.0 -2.8
Supplements: Zinc 0.1 0.1 0.2 0.2 -0.5 -0.1
Medication: Co-codamol 0.4 0.5 1.2 0.2 -0.5 -1.1
Medication: Metformin 0.2 0.3 0.4 0.7 -0.6 0.1
Diabetes (father) 0.4 0.5 1.2 1.1 -0.6 0.0
Diabetes (mother) 0.1 0.2 0.3 -0.3 0.5 0.4
Severe depression (siblings) 0.5 0.5 1.6 -0.1 0.2 1.3
Pack years adult smoking proportion 0.2 0.3 0.6 0.8 -0.4 -0.4
Impedance of leg (right) 0.5 2.5 4.2 -2.0 1.7 -0.8
Leg fat-free mass (left) 0.2 1.2 1.8 0.3 1.3 1.3
Trunk fat percentage 0.8 3.2 5.3 1.6 -1.2 2.3
Hand grip strength (right) 0.4 1.2 2.1 -0.5 1.1 1.5
Townsend deprivation index at recruitment 0.1 0.2 0.4 0.1 -0.7 0.1
Current tobacco smoking 3.2 5.2 6.9 2.4 -1.7 2.6
Average weekly fortified wine intake 0.3 0.4 0.8 0.5 -0.9 0.3
Maternal smoking around birth 0.5 0.7 2.0 0.3 0.3 1.4
Fed-up feelings 2.8 5.1 10.8 1.3 -1.6 3.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.6 3.5 8.3 0.9 -1.2 2.9
Relative age voice broke 1.3 2.0 3.4 -1.8 1.5 -0.5
Taking other prescription medications 0.1 0.1 0.2 -0.2 0.0 0.5
Age when periods started (menarche) 0.1 0.3 0.7 0.8 -0.3 -0.0
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 1.8 1.4 -0.8 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.7 -0.2 -0.1 -0.8
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 3.1 1.0 -1.3 1.8
Qualifications: CSEs or equivalent 3.5 4.6 5.2 2.3 -1.9 2.2
Serious illness, injury or assault to yourself 0.8 1.0 2.9 0.3 -0.0 1.7
High blood pressure 0.1 0.3 0.6 0.5 -0.8 0.4
Hayfever, allergic rhinitis or eczema 0.6 1.2 2.0 -1.4 0.6 -1.1
Multivitamins +/- minerals 5.1 6.5 10.1 2.4 -1.8 3.2
Stomach or abdominal pain in last month 2.6 3.2 5.3 1.7 -1.2 2.3
Supplements: Glucosamine 2.4 3.1 4.8 2.2 -2.0 0.7
Diverticular disease/diverticulitis (self-reported) 2.6 3.1 5.2 -1.4 1.5 -2.3
Medication: Atenolol 0.9 1.2 2.2 1.5 -1.1 -0.0
Medication: Levothyroxine sodium 0.2 0.4 0.5 0.7 -0.4 -0.7
Sitting height 3.4 24.5 39.1 -4.7 6.2 -3.5
Chronic bronchitis/emphysema (father) 5.1 6.0 10.3 -2.4 3.2 -1.4
High blood pressure (mother) 2.1 2.9 8.3 0.5 -0.5 2.9
Body mass index (BMI) 1.4 5.9 7.3 2.7 -2.4 2.1
Impedance of leg (left) 0.4 2.1 4.0 -2.0 1.5 -0.6
Leg predicted mass (left) 0.2 1.3 2.0 0.3 1.3 1.4
Trunk fat mass 0.5 2.2 4.5 1.3 -0.5 2.1
Waist circumference 0.4 1.6 2.9 1.7 -0.8 1.2
Number of incorrect matches in round 0.0 0.0 0.1 0.1 0.1 0.3
Past tobacco smoking 0.1 0.1 0.3 0.1 0.5 -0.3
Alcohol usually taken with meals 1.8 3.0 5.0 2.2 -1.9 0.7
Nervous feelings 0.1 0.2 0.4 0.1 -0.1 -0.7
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 2.6 1.1 -1.6 1.5
Hearing difficulty/problems with background noise 0.5 0.8 1.4 -1.2 0.7 -0.6
Hair/balding pattern: Pattern 2 0.2 0.2 0.3 0.6 0.1 0.6
Had menopause 1.3 1.6 3.5 1.9 -1.1 0.0
Had other major operations 0.3 0.4 0.6 0.8 -0.5 0.5
Forced vital capacity (FVC) 1.5 5.6 10.9 -2.1 3.3 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.1 -0.5 -0.1 -1.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 1.2 1.1 -1.1 0.5
Qualifications: None of the above 1.0 2.1 2.9 -1.7 1.7 0.7
Financial difficulties in last 2 years 1.8 2.5 3.9 2.0 -1.4 1.2
Mouth/teeth dental problems 1.1 1.7 2.6 1.6 -1.6 0.3
Heart attack 0.0 0.0 0.0 0.2 0.0 -0.2
Allergy 0.5 1.2 2.8 1.7 -0.9 0.1
Pain all over the body in last month 0.4 0.4 0.8 -0.6 0.9 0.0
Diabetes (self-reported) 0.3 0.5 1.4 -0.3 -0.1 -1.2
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 5.3 -0.4 -0.1 -2.3
Medication: Ramipril 0.1 0.2 0.4 -0.4 -0.1 0.7
Medication: Simvastatin 0.2 0.3 0.8 0.2 0.1 0.9
Fluid intelligence score 0.1 0.2 0.3 -0.6 0.4 0.3
Illnesses of siblings 0.4 0.5 0.9 0.3 -0.8 0.9
Neuroticism score 4.8 10.0 11.1 3.0 -3.2 3.3
Weight 0.3 1.4 3.2 1.0 0.4 1.8
Impedance of arm (right) 0.3 1.4 2.2 -1.5 1.3 -0.5
Arm fat percentage (right) 1.4 5.5 6.5 2.4 -2.5 2.1
Trunk fat-free mass 0.4 2.4 6.4 -1.0 2.5 0.2
Hip circumference 0.1 0.3 0.7 -0.0 0.6 0.8
Time employed in main current job 0.2 0.2 0.5 0.7 -0.3 0.4
Alcohol intake versus 10 years previously 0.2 0.4 0.6 0.3 -0.7 0.8
Father’s age at death 0.1 0.2 0.3 0.1 -0.5 0.5
Worrier / anxious feelings 0.6 1.2 1.6 1.1 -1.2 0.9
Frequency of tiredness / lethargy in last 2 weeks 3.3 5.3 11.2 1.5 -1.5 3.4
Falls in the last year 2.9 3.9 8.6 1.5 -1.0 2.9
Hair/balding pattern: Pattern 3 0.9 1.4 3.3 -0.9 0.2 -1.8
Number of live births 0.5 0.8 1.7 1.3 -0.3 0.7
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 3.9 -0.7 2.0 1.9
Pulse rate 0.5 0.8 1.6 0.4 -0.7 -1.3
Happiness 0.6 0.7 1.0 0.8 -1.0 0.8
Noisy workplace 0.3 0.4 0.6 0.7 -0.5 0.6
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.7 -0.8 0.8 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.8 1.0 2.8 -0.0 -0.3 1.7
Mouth/teeth dental problems: Dentures 0.3 0.5 1.3 -0.2 0.3 1.1
Asthma 0.4 0.7 1.9 -1.4 0.1 -0.5
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.6 2.8 1.7 -1.6 1.6
Medication: Cholesterol lowering 0.8 1.2 1.9 -0.9 1.4 -0.9
Depression (self-reported) 7.6 9.1 11.4 2.8 -2.9 3.4
Medication: Lansoprazole 1.9 2.2 2.8 1.2 -1.5 1.7
Prospective memory result 2.6 3.2 4.9 -2.0 2.2 -0.9
Lung cancer (father) 0.1 0.1 0.3 -0.2 0.5 0.1
Illnesses of mother 0.4 0.4 1.2 -0.3 0.1 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.7 5.1 -1.2 2.3 2.1
Pulse wave Arterial Stiffness index 0.7 0.8 1.0 1.0 -1.0 0.6
Impedance of arm (left) 0.3 1.3 2.3 -1.5 1.2 0.1
Arm fat mass (right) 0.6 2.3 3.2 1.6 -1.1 1.8
Trunk predicted mass 0.5 2.6 6.7 -1.0 2.6 0.2
Standing height 1.9 18.6 40.3 -3.9 6.3 -0.6
Length of working week for main job 1.0 1.1 1.7 1.2 -1.3 0.5
Exposure to tobacco smoke at home 0.9 1.0 1.6 -0.6 1.1 1.3
Breastfed as a baby 0.3 0.3 0.6 0.8 -0.5 0.1
Tense / ‘highly strung’ 0.1 0.2 0.3 0.3 -0.2 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.8 4.3 10.0 1.5 -0.9 3.2
Hair/balding pattern: Pattern 4 0.8 2.0 4.8 0.7 -0.9 2.2
Birth weight of first child 0.8 1.4 1.8 1.3 -1.0 1.3
Peak expiratory flow (PEF) 1.3 3.0 6.4 1.6 -0.5 2.5
Pulse wave reflection index 0.7 0.8 2.0 -0.6 0.2 1.4
Ever highly irritable/argumentative for 2 days 6.0 7.3 10.2 2.8 -1.9 3.2
Loud music exposure frequency 1.0 1.1 1.5 1.2 -0.8 1.1
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.7 -0.2 0.8 0.3
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 1.3 -1.1 1.0 -0.2
Blood clot in the leg (DVT) 0.6 0.8 1.9 0.6 0.3 1.4
Medication: Paracetamol 0.2 0.3 0.6 -0.5 0.4 -0.7
Headache pain in last month 0.6 1.0 1.9 -1.4 1.0 0.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.3 0.5 -0.4 -0.1
Glaucoma (self-reported) 0.4 0.5 1.3 -0.2 0.3 -1.2
Gout (self-reported) 0.8 1.1 2.0 -1.1 1.4 -0.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.5 0.6 -0.4 -0.7
Medication: Amlodipine 1.3 1.9 5.1 0.7 -0.2 2.3
Medication: Ventolin 100micrograms inhaler 0.5 0.7 1.3 -0.7 -0.5 -1.1
Birth weight 0.6 1.3 2.4 1.6 -0.9 0.9
Chronic bronchitis/emphysema (mother) 0.8 0.9 1.7 -0.6 0.7 -1.3
High blood pressure (siblings) 0.7 1.0 1.2 -0.8 1.1 -1.1
Forced vital capacity (FVC), Best measure 2.3 8.2 14.5 -2.7 3.8 1.7
Body fat percentage 1.2 4.8 5.4 2.2 -2.1 2.3
Leg fat percentage (right) 1.8 6.5 8.5 2.7 -2.9 2.0
Arm fat-free mass (right) 0.3 1.6 4.2 -0.5 2.1 0.6
Exposure to tobacco smoke outside home 2.0 2.7 8.2 0.1 0.1 2.9
Comparative body size at age 10 0.2 0.5 0.7 0.5 -0.8 0.7
Number of full brothers 1.8 2.2 3.3 -1.8 1.8 0.3
Worry too long after embarrassment 2.4 4.0 5.9 2.4 -2.4 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 3.7 4.7 5.6 2.4 -2.0 2.2
Wheeze or whistling in the chest in last year 0.7 1.3 2.0 0.6 -1.4 1.2
Number of children fathered 1.4 1.6 1.7 1.3 -1.2 1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 4.2 0.1 -0.7 -2.1
Age at first live birth 3.3 5.8 8.3 -2.4 1.8 -2.9
Pulse wave peak to peak time 1.5 1.8 2.6 -1.4 1.6 -0.9
Health satisfaction 0.6 0.8 1.7 0.9 -0.1 1.3
Shortness of breath walking on level ground 1.4 1.7 2.6 1.6 -1.1 1.2
Qualifications: College or University degree 0.2 0.7 2.2 0.1 0.1 -1.5
Eye problems/disorders: None of the above 1.7 1.9 3.0 1.1 -1.7 1.3
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.4 -0.3 0.6 0.5
Emphysema/chronic bronchitis 0.5 0.6 1.0 1.0 -0.7 0.5
Medication for pain relief, constipation, heartburn 0.1 0.2 0.4 -0.7 0.2 -0.3
Neck or shoulder pain in last month 0.8 1.2 2.7 -0.7 0.7 1.6
Medication: Blood pressure 0.0 0.1 0.1 -0.4 -0.0 0.3
Angina (self-reported) 1.1 1.5 2.5 1.6 -0.9 1.1
Migraine (self-reported) 0.3 0.4 0.7 0.2 -0.9 0.7
Medication: Ibuprofen 1.4 1.7 2.0 1.4 -1.3 1.2
Medication: Allopurinol 0.2 0.3 0.7 -0.3 0.8 0.2
Medication: Omeprazole 0.2 0.2 0.5 0.4 0.1 0.7
Medication: Seretide 50 evohaler 0.3 0.4 0.8 -0.5 -0.2 -0.9
Mean time to correctly identify matches 0.3 0.6 0.9 -0.9 0.8 0.4
Heart disease (mother) 0.3 0.3 0.8 0.5 -0.1 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.7 3.2 6.0 1.5 -2.4 1.1
Whole body fat mass 0.7 3.0 4.6 1.8 -1.1 2.1
Leg fat mass (right) 0.9 3.7 4.5 2.1 -1.7 1.9
Arm predicted mass (right) 0.3 1.4 3.3 -0.4 1.8 0.8
Pulse rate, automated reading 0.5 1.5 4.2 -0.5 -0.1 -2.1
Alcohol intake frequency. 0.3 0.6 1.0 -0.8 1.0 -0.5
Comparative height size at age 10 1.3 7.0 13.8 -2.3 3.7 1.4
Number of full sisters 3.2 3.9 5.6 2.4 -1.4 2.0
Suffer from ‘nerves’ 0.8 1.2 2.5 0.8 -0.7 1.6
Overall health rating 0.3 0.8 1.9 0.5 -0.2 1.4
Chest pain or discomfort 2.2 3.2 6.6 1.4 -1.1 2.6
Had major operations 0.2 0.2 0.6 0.1 -0.3 0.7
Age at last live birth 1.4 2.0 3.3 -1.0 1.3 -1.8
Family relationship satisfaction 2.6 3.2 4.4 2.0 -2.1 1.1
Leg pain on walking 3.6 4.6 5.7 2.4 -1.9 2.1
Qualifications: NVQ or HND or HNC or equivalent 1.4 1.7 2.4 1.2 -1.6 1.2
Commuting to job workplace: Car/motor vehicle 1.4 1.6 2.5 1.6 -1.2 1.0
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.4 -0.5 0.6 -1.6
Medication: Aspirin 0.2 0.2 0.4 0.6 0.0 0.6
Supplements: Vitamin C 2.5 3.0 4.7 1.9 -2.2 0.9
Knee pain experienced in last month 0.6 0.9 2.2 0.8 -0.2 1.5
Hypertension (Self-reported) 0.1 0.2 0.5 0.3 -0.7 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.5 5.2 6.6 2.6 -2.4 1.8
Illnesses of father: Heart disease 1.1 1.5 3.5 0.6 -0.8 -1.9
Illnesses of siblings: Diabetes 0.0 0.0 0.0 -0.1 0.1 0.2
Smoking status: Previous 0.4 0.6 1.2 -1.1 0.3 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.3 3.8 -1.4 2.0 1.0
Whole body fat-free mass 0.3 1.8 4.9 -0.5 2.2 0.6
Leg fat-free mass (right) 0.2 1.3 2.1 0.3 1.2 1.5
Arm fat percentage (left) 1.6 6.4 6.8 2.5 -2.6 2.4
Average weekly red wine intake 1.4 2.1 5.8 0.1 -0.7 -2.4
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 0.5 -1.0 -0.0
Mood swings 1.2 2.1 4.4 0.9 -1.0 2.1
Loneliness, isolation 1.7 2.3 5.1 0.5 -1.2 2.3
Long-standing illness, disability or infirmity 0.5 0.8 2.4 -0.1 -0.2 1.6
Ever had bowel cancer screening 0.8 0.9 1.6 1.2 -1.0 0.3
Diabetes diagnosed by doctor 0.3 0.5 0.7 -0.8 0.5 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 2.1 1.4 -1.1 -0.6
Friendships satisfaction 1.6 2.0 4.8 0.6 -0.8 2.2
Qualifications: nursing, teaching 1.7 2.7 4.9 1.8 -2.2 0.3
Commuting to job workplace: Walk 2.4 2.5 4.0 -2.0 1.7 -0.9
Eye problems/disorders: Cataract 3.0 3.5 4.0 -1.6 2.0 -1.9
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 1.6 -1.0 1.0 -1.3
Medication for cholesterol 4.0 6.0 7.4 -2.7 2.5 -2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.5 -0.6 0.7 -0.4
Back pain experienced in last month 2.5 3.6 7.1 1.8 -0.8 2.7
Mineral and other dietary supplements 3.6 4.9 7.3 -2.7 2.7 -0.3
Breast cancer (self-reported) 0.3 0.4 0.7 0.6 0.1 -0.9
Asthma (self-reported) 0.5 0.9 2.4 -1.6 0.4 -0.4
Osteoporosis (self-reported) 0.8 1.0 2.2 -0.8 1.5 -0.3
Osteoarthritis (self-reported) 0.7 0.9 1.4 1.0 -1.2 -0.4
Medication: Aspirin 0.4 0.5 0.9 0.9 -0.4 0.6
Medication: Gliclazide 0.2 0.2 0.4 0.4 -0.6 -0.0
Illnesses of father: None of the above (group 1) 0.5 0.7 1.9 0.2 -0.2 1.4
Smoking status: Current 3.0 4.8 6.2 2.4 -1.6 2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.3 0.2 -0.2 1.5
Whole body water mass 0.3 1.9 5.1 -0.5 2.2 0.7
Leg predicted mass (right) 0.2 1.2 2.1 0.3 1.2 1.4
Arm fat mass (left) 0.8 3.2 4.7 1.8 -1.4 2.2
Number of self-reported non-cancer illnesses 0.0 0.1 0.1 -0.4 0.1 -0.1
Average weekly champagne plus white wine intake 0.1 0.2 0.4 0.0 0.3 0.6
Miserableness 1.7 3.0 6.8 0.8 -1.2 2.6
Guilty feelings 2.2 3.4 6.3 1.8 -2.5 0.8
Wears glasses or contact lenses 0.5 0.6 1.5 -0.5 0.3 -1.2
Ever taken oral contraceptive pill 1.5 1.6 3.5 -1.9 1.1 -0.3
Hearing aid user 0.3 0.3 0.7 -0.3 -0.9 -0.3
Mother’s age at death 0.1 0.1 0.2 0.0 -0.4 0.2
Financial situation satisfaction 0.9 1.2 1.7 1.3 -1.1 0.7
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.3 -0.1 -0.5 0.2
Commuting to job workplace: Public transport 0.1 0.2 0.4 0.3 0.1 0.6
Eye problems/disorders: Glaucoma 0.9 1.0 1.7 -0.8 0.8 -1.3
Medication: Blood pressure 0.1 0.2 0.3 0.4 -0.5 0.5
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.4 0.9 -1.0 1.2
Supplements: Fish oil (including cod liver oil) 5.7 7.4 12.5 3.5 -3.0 0.7
High cholesterol (Self-reported) 0.1 0.3 0.3 0.5 -0.5 0.6
Medication: Bendroflumethiazide 1.4 2.1 3.4 -1.7 1.8 -0.2
Medication: Paracetamol 0.5 0.8 1.1 -1.0 0.5 -1.1
Medication: Lisinopril 0.1 0.1 0.3 0.2 -0.6 -0.1
Medication: Atorvastatin 0.1 0.1 0.2 0.4 -0.3 -0.5
Illnesses of father: High blood pressure 0.8 1.0 1.9 -1.4 1.0 -0.1
Alcohol drinker status: Never 0.5 0.6 0.7 -0.7 0.8 -0.8
Ever smoked 0.4 0.8 1.2 0.6 -0.9 1.1
Basal metabolic rate 0.3 1.4 3.3 -0.2 1.8 0.9
Leg fat percentage (left) 1.9 6.7 8.4 2.6 -2.9 2.2
Arm fat-free mass (left) 0.2 1.2 3.3 -0.4 1.8 0.4
Number of operations (self-reported) 1.1 1.7 2.9 0.8 -1.2 1.7
Average weekly beer plus cider intake 0.7 1.0 2.0 -0.7 0.8 -1.4
Irritability 2.2 3.8 8.6 1.6 -0.6 2.9
Risk taking 0.3 0.4 0.7 0.8 0.1 0.8
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.4 -1.2 0.8 0.7
Fractured/broken bones in last 5 years 0.1 0.1 0.1 0.3 0.2 -0.3
Age started oral contraceptive pill 0.3 0.4 0.6 0.7 -0.7 0.1
Diastolic blood pressure, automated reading 1.1 3.3 5.1 1.9 -2.3 1.2
Ever depressed for a whole week 4.4 5.4 6.7 2.6 -2.5 1.9
Unable to work because of sickness or disability 3.2 4.1 7.3 1.8 -1.4 2.7
Commuting to job workplace: Cycle 0.1 0.1 0.3 0.1 0.3 -0.5
Myopia 0.8 1.2 2.9 -0.5 0.6 -1.7
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.1 -0.6 0.5 -1.1
Cholesterol lowering medication 1.6 2.3 4.0 1.5 -0.9 2.0
Medication: Omeprazole (e.g. Zanprol) 0.0 0.1 0.1 0.3 0.1 0.3
Pain experienced in last month 0.6 1.0 2.3 0.2 -0.8 -1.5
Supplements: Calcium 0.1 0.2 0.3 0.4 0.0 0.6
Basal cell carcinoma (self-reported) 0.2 0.3 0.4 0.6 0.1 0.6
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 0.1 0.0 -0.4
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.4 0.5 0.3 1.2
Heart disease (siblings) 0.3 0.3 0.7 -0.0 0.9 -0.5
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.0 0.5 0.1
Pack years of smoking 0.2 0.4 0.7 0.6 -0.3 -0.8
Impedance of whole body 0.5 2.6 4.6 -2.1 1.7 -0.5
Leg fat mass (left) 0.8 3.0 3.5 1.9 -1.5 1.8
Arm predicted mass (left) 0.2 0.9 2.2 0.0 1.5 0.8