[Hub]/) : Traits : Forced vital capacity (FVC), Best measure : ← →

chr16:68,523,336-71,093,625

Best TWAS P=9.15e-17 · Best GWAS P=1.79e-25 conditioned to 0.13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Thyroid	NOB1	0.03	0.01	enet	6	0.02	7.7e-03	-7.0	8.3	9.1e-17	-0.76	0.26	0.20	TRUE
3	GTEx	Adipose Subcutaneous	NFAT5	0.09	0.02	enet	19	0.05	8.2e-05	-2.4	-6.8	8.4e-12	0.38	0.17	0.22	TRUE
7	GTEx	Esophagus Muscularis	TMED6	0.08	0.04	enet	5	0.06	1.2e-04	-4.9	-6.2	5.1e-10	0.11	0.32	0.06	TRUE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	NFAT5	0.02	0.01	enet	5	0.01	6.6e-04	-3.7	-8.0	1.3e-15	0.76	0.03	0.46	FALSE
13	GTEx	Thyroid	CTD-2033A16.3	0.03	0.02	enet	7	0.02	6.7e-03	-5.5	7.7	1.1e-14	-0.72	0.21	0.28	FALSE
11	GTEx	Testis	WWP2	0.30	0.10	lasso	5	0.16	9.2e-08	-5.2	-7.5	7.7e-14	0.68	0.51	0.25	FALSE
15	METSIM	Adipose	WWP2	0.08	0.04	enet	19	0.07	2.7e-10	7.4	7.4	1.3e-13	-0.51	0.98	0.02	FALSE
41	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CLEC18A	0.20	0.09	lasso	5	0.08	8.8e-04	7.4	7.4	1.8e-13	-0.59	0.00	0.92	FALSE
14	METSIM	Adipose	NOB1	0.03	0.03	lasso	2	0.03	2.8e-05	-6.2	7.3	2.7e-13	-0.57	0.27	0.68	FALSE
39	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CLEC18A	0.17	0.09	enet	8	0.11	8.5e-04	5.9	7.1	1.1e-12	-0.52	0.01	0.82	FALSE
36	The Cancer Genome Atlas	Rectum Adenocarcinoma	CLEC18A	0.15	0.03	blup	23	0.09	4.3e-03	5.9	6.8	7.9e-12	-0.57	0.01	0.40	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NOB1	0.04	0.05	enet	12	0.04	7.2e-06	-6.4	6.8	1.5e-11	-0.43	0.97	0.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	NQO1	0.02	0.01	blup	39	0.01	4.3e-03	-5.8	-6.7	2.2e-11	0.73	0.06	0.16	FALSE
38	The Cancer Genome Atlas	Soft Tissue Sarcoma	PDXDC2	0.05	0.01	blup	26	0.03	9.5e-03	5.9	6.4	1.3e-10	-0.40	0.01	0.69	FALSE
21	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PDXDC2	0.20	0.02	blup	26	0.07	1.8e-04	6.0	6.3	2.7e-10	-0.35	0.02	0.83	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PDXDC2	0.14	0.05	enet	6	0.05	3.2e-06	6.0	6.2	6.6e-10	-0.42	0.01	0.98	FALSE
22	The Cancer Genome Atlas	Colon Adenocarcinoma	CLEC18A	0.14	0.18	lasso	5	0.15	4.5e-09	5.9	6.1	9.0e-10	-0.45	0.42	0.57	FALSE
37	The Cancer Genome Atlas	Soft Tissue Sarcoma	CLEC18A	0.12	0.11	lasso	2	0.11	3.4e-07	6.0	6.0	1.8e-09	-0.46	0.65	0.33	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CLEC18C	0.06	0.05	lasso	1	0.04	3.8e-05	6.0	6.0	2.4e-09	-0.36	0.65	0.11	FALSE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDXDC2	0.03	0.04	enet	4	0.04	4.0e-05	6.0	5.9	2.7e-09	-0.36	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CLEC18A	0.10	0.06	lasso	2	0.04	6.3e-03	5.9	5.9	3.7e-09	-0.43	0.04	0.20	FALSE
24	The Cancer Genome Atlas	Glioblastoma Multiforme	PDXDC2	0.10	0.12	lasso	3	0.10	4.7e-04	5.9	5.9	3.7e-09	-0.43	0.01	0.76	FALSE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CLEC18A	0.06	0.10	lasso	1	0.09	6.9e-11	5.9	5.9	4.0e-09	-0.42	0.97	0.03	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PDXDC2	0.09	0.01	blup	26	0.06	4.7e-05	6.0	5.9	4.1e-09	-0.48	0.01	0.90	FALSE
10	GTEx	Skin Sun Exposed Lower leg	CYB5B	0.12	0.00	enet	18	0.02	5.4e-03	-1.3	-5.8	6.2e-09	0.48	0.32	0.39	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	PDXDC2	0.12	0.16	blup	26	0.15	1.1e-14	6.0	5.8	6.3e-09	-0.42	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PDXDC2	0.26	0.19	lasso	3	0.23	1.3e-09	5.9	5.7	1.1e-08	-0.37	0.02	0.98	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	PDXDC2P	0.26	0.17	lasso	5	0.13	2.2e-04	6.0	5.7	1.4e-08	-0.35	0.34	0.04	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	NQO1	0.06	0.04	lasso	3	0.01	5.3e-02	-5.8	-5.6	1.8e-08	0.53	0.04	0.07	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLEC18A	0.16	0.17	enet	10	0.19	6.8e-37	5.9	5.5	3.0e-08	-0.41	0.99	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	COG4	0.19	0.23	enet	28	0.27	4.3e-33	-4.0	5.5	3.1e-08	-0.25	0.99	0.01	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	PDXDC2	0.15	0.25	enet	12	0.29	8.2e-33	6.0	5.4	5.8e-08	-0.37	0.01	0.99	FALSE
16	YFS	Blood	PDPR	0.02	0.00	enet	20	0.01	1.8e-05	0.6	-5.4	5.9e-08	0.55	0.02	0.64	FALSE
4	GTEx	Brain Cerebellum	CTD-2033A16.3	0.14	0.15	lasso	4	0.12	2.2e-04	-6.3	5.4	8.0e-08	-0.40	0.16	0.10	FALSE
8	GTEx	Liver	TMED6	0.37	0.22	lasso	7	0.24	1.9e-07	4.3	-5.3	9.0e-08	0.15	0.60	0.05	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDXDC2	0.13	0.05	lasso	4	0.05	9.4e-06	5.9	5.3	9.6e-08	-0.37	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	CLEC18A	0.13	0.17	enet	11	0.17	1.8e-19	5.9	5.3	1.1e-07	-0.39	0.99	0.01	FALSE
6	GTEx	Cells Transformed fibroblasts	COG4	0.23	0.18	lasso	5	0.20	1.3e-14	-4.0	5.3	1.2e-07	-0.24	0.99	0.01	FALSE
33	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CLEC18A	0.20	0.14	enet	12	0.15	1.5e-06	5.9	5.3	1.2e-07	-0.39	0.53	0.22	FALSE
40	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLEC18A	0.07	0.05	blup	23	0.04	3.7e-04	5.9	5.3	1.2e-07	-0.40	0.21	0.26	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	CLEC18A	0.24	0.26	blup	23	0.27	1.3e-26	5.9	5.2	2.4e-07	-0.36	0.99	0.01	FALSE
29	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TMED6	0.21	0.06	enet	11	0.14	2.5e-07	4.3	-5.2	2.5e-07	0.16	0.01	0.85	FALSE
9	GTEx	Lung	SNTB2	0.08	0.05	enet	12	0.04	2.8e-04	-2.9	5.1	3.1e-07	-0.25	0.56	0.20	FALSE