Best TWAS P=1.29e-12 · Best GWAS P=1.75e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ARFRP1 | 0.07 | 0.07 | lasso | 3 | 0.06 | 5.3e-08 | 6.8 | -6.6 | 3.4e-11 | -0.95 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | STMN3 | 0.39 | 0.08 | lasso | 5 | 0.22 | 2.1e-06 | 5.1 | 5.3 | 9.0e-08 | 0.63 | 0.19 | 0.54 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | CTD-3184A7.4 | 0.09 | 0.00 | enet | 28 | 0.00 | 1.4e-01 | 3.4 | 5.2 | 2.0e-07 | 0.48 | 0.02 | 0.83 | FALSE |
| 4 | GTEx | Whole Blood | STMN3 | 0.10 | 0.00 | lasso | 3 | 0.00 | 1.2e-01 | 3.9 | -5.5 | 4.6e-08 | -0.72 | 0.02 | 0.76 | FALSE |
| 5 | METSIM | Adipose | TPD52L2 | 0.03 | 0.00 | bslmm | 207 | 0.02 | 1.5e-03 | -3.2 | -6.5 | 1.1e-10 | -0.68 | 0.02 | 0.74 | FALSE |
| 6 | YFS | Blood | LIME1 | 0.12 | 0.19 | enet | 15 | 0.19 | 5.3e-59 | 7.0 | 7.1 | 1.3e-12 | 0.99 | 0.00 | 1.00 | TRUE |
| 7 | The Cancer Genome Atlas | Esophageal Carcinoma | GMEB2 | 0.16 | 0.04 | blup | 64 | 0.05 | 1.0e-02 | -1.4 | -5.2 | 1.9e-07 | -0.49 | 0.02 | 0.19 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LIME1 | 0.02 | 0.03 | blup | 47 | 0.02 | 6.2e-03 | 4.8 | 5.8 | 6.0e-09 | 0.83 | 0.04 | 0.53 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Adenocarcinoma | TNFRSF6B | 0.02 | 0.01 | enet | 7 | 0.01 | 6.9e-03 | 5.1 | 6.3 | 3.0e-10 | 0.92 | 0.02 | 0.88 | FALSE |
| 10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RTEL1 | 0.05 | 0.04 | blup | 56 | 0.03 | 4.2e-03 | 6.3 | 6.0 | 1.5e-09 | 0.88 | 0.01 | 0.80 | FALSE |
| 11 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | TNFRSF6B | 0.05 | 0.02 | blup | 44 | 0.03 | 2.9e-03 | 7.0 | 6.7 | 2.2e-11 | 0.92 | 0.01 | 0.74 | FALSE |
| 12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARFRP1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.2e-03 | 6.8 | -6.8 | 8.1e-12 | -0.96 | 0.01 | 0.96 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIME1 | 0.04 | 0.05 | blup | 47 | 0.05 | 9.0e-06 | 7.1 | 6.6 | 3.4e-11 | 0.97 | 0.01 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC2A4RG | 0.05 | 0.01 | blup | 48 | 0.02 | 2.0e-03 | 7.0 | -6.5 | 5.6e-11 | -0.84 | 0.01 | 0.95 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZGPAT | 0.05 | 0.06 | lasso | 3 | 0.06 | 5.5e-07 | 4.8 | -5.4 | 6.6e-08 | -0.80 | 0.05 | 0.95 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | LIME1 | 0.10 | 0.02 | blup | 47 | 0.04 | 1.5e-02 | 7.0 | 5.6 | 1.9e-08 | 0.90 | 0.01 | 0.64 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | ARFRP1 | 0.04 | 0.00 | blup | 51 | 0.00 | 1.3e-01 | 7.0 | -5.9 | 4.6e-09 | -0.80 | 0.01 | 0.61 | FALSE |