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chr15:77,859,168-79,802,863

Best TWAS P=2.89e-76 · Best GWAS P=7.41e-76 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
57	The Cancer Genome Atlas	Esophageal Carcinoma	CHRNA5	0.17	0.15	lasso	4	0.14	3.1e-05	18.13	-18.5	2.9e-76	-0.97	0.01	0.97	TRUE
49	YFS	Blood	PSMA4	0.08	0.08	lasso	10	0.11	8.3e-35	18.10	18.1	1.9e-73	0.82	0.49	0.51	TRUE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNA5	0.04	0.01	enet	10	0.03	6.0e-04	18.13	-14.6	5.8e-48	-0.77	0.01	0.79	TRUE
81	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB4	0.06	0.03	lasso	2	0.06	4.4e-06	11.64	11.1	1.3e-28	0.65	0.29	0.66	TRUE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNA5	0.20	0.13	lasso	3	0.14	7.0e-15	-7.65	-8.3	1.3e-16	-0.63	1.00	0.00	TRUE
30	GTEx	Colon Transverse	CHRNA5	0.18	0.14	lasso	4	0.13	9.4e-07	7.98	-6.7	2.0e-11	-0.53	0.25	0.54	TRUE
25	GTEx	Cells EBV-transformed lymphocytes	ADAMTS7	0.32	0.11	lasso	5	0.17	2.8e-06	-5.47	-6.1	1.1e-09	-0.19	0.58	0.05	TRUE
47	METSIM	Adipose	DNAJA4	0.08	0.00	enet	33	0.04	3.5e-06	1.52	6.0	1.5e-09	0.21	0.31	0.18	TRUE
34	GTEx	Liver	PSMA4	0.18	0.14	lasso	1	0.11	6.5e-04	18.13	18.1	2.0e-73	0.96	0.03	0.88	FALSE
56	The Cancer Genome Atlas	Esophageal Carcinoma	CHRNA3	0.24	0.15	enet	5	0.16	6.5e-06	18.13	-17.4	6.3e-68	-0.93	0.01	0.97	FALSE
72	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CHRNA5	0.15	0.07	blup	50	0.09	2.5e-04	-12.21	-16.0	1.5e-57	-0.65	0.16	0.60	FALSE
45	GTEx	Testis	CHRNA5	0.16	0.07	enet	11	0.11	1.4e-05	18.13	15.7	1.2e-55	0.86	0.01	0.98	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNA3	0.05	0.02	blup	44	0.02	7.6e-03	18.13	-15.6	1.2e-54	-0.92	0.01	0.94	FALSE
48	YFS	Blood	IREB2	0.18	0.20	enet	28	0.24	4.0e-78	16.14	-15.2	3.7e-52	-0.71	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNA3	0.04	0.04	blup	44	0.06	1.4e-06	17.27	-14.8	9.5e-50	-0.88	0.02	0.98	FALSE
70	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNA5	0.02	0.01	blup	50	0.02	2.6e-03	-7.83	-14.3	1.4e-46	-0.86	0.02	0.68	FALSE
6	GTEx	Adipose Subcutaneous	HYKK	0.08	0.01	lasso	2	0.01	3.0e-02	-7.27	-14.3	3.0e-46	-0.89	0.02	0.92	FALSE
68	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMA4	0.08	0.02	blup	40	0.03	1.1e-02	-11.23	-13.3	1.9e-40	-0.50	0.05	0.16	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PSMA4	0.03	0.02	blup	40	0.02	3.1e-03	-7.81	13.3	3.0e-40	0.81	0.03	0.48	FALSE
29	GTEx	Colon Sigmoid	CHRNA5	0.20	-0.01	enet	14	0.03	2.9e-02	17.38	-12.3	7.0e-35	-0.57	0.03	0.69	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADAMTS7	0.08	0.07	lasso	3	0.07	4.9e-08	12.01	11.9	1.0e-32	0.64	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADAMTS7	0.08	0.07	lasso	3	0.06	4.2e-04	11.82	11.9	2.0e-32	0.64	0.00	0.93	FALSE
32	GTEx	Heart Left Ventricle	PSMA4	0.18	0.02	enet	21	0.06	4.4e-04	-7.32	11.5	1.5e-30	0.77	0.02	0.97	FALSE
79	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PSMA4	0.11	0.01	blup	40	0.03	3.0e-02	-7.81	11.5	2.1e-30	0.75	0.05	0.49	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNA5	0.16	0.25	lasso	6	0.25	2.7e-24	-7.65	-11.3	1.5e-29	-0.75	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNA3	0.16	0.00	enet	22	0.02	2.2e-03	-6.95	-11.0	6.4e-28	-0.60	0.02	0.74	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNA3	0.02	0.02	blup	44	0.02	4.8e-05	-7.27	-10.5	5.9e-26	-0.74	0.31	0.49	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CHRNA5	0.12	0.15	blup	50	0.14	1.4e-08	-7.69	-10.1	7.3e-24	-0.71	0.94	0.06	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	AGPHD1	0.12	0.01	enet	11	0.06	6.5e-07	-7.37	-9.6	7.0e-22	-0.46	0.03	0.53	FALSE
22	GTEx	Breast Mammary Tissue	CHRNA5	0.28	0.22	lasso	11	0.20	1.9e-10	-7.81	-9.3	8.5e-21	-0.64	0.99	0.01	FALSE
76	The Cancer Genome Atlas	Soft Tissue Sarcoma	CHRNA5	0.11	0.13	enet	9	0.16	1.4e-09	-7.37	-9.2	5.2e-20	-0.69	0.98	0.02	FALSE
67	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CHRNA5	0.29	0.25	enet	16	0.25	6.8e-12	-7.65	-9.1	6.1e-20	-0.61	1.00	0.00	FALSE
9	GTEx	Artery Tibial	ADAMTS7	0.13	0.07	lasso	4	0.06	9.2e-06	7.78	9.1	1.4e-19	0.42	0.95	0.01	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNA5	0.08	0.13	enet	13	0.14	1.6e-26	-7.32	-8.8	9.5e-19	-0.65	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNA5	0.39	0.62	enet	16	0.62	9.4e-90	-7.81	-8.8	9.7e-19	-0.63	1.00	0.00	FALSE
7	GTEx	Artery Aorta	CHRNA5	0.15	0.07	lasso	6	0.05	9.3e-04	-7.79	-8.7	5.3e-18	-0.58	0.53	0.29	FALSE
43	GTEx	Skin Sun Exposed Lower leg	RP11-762H8.4	0.13	0.03	enet	36	0.03	2.2e-03	-0.95	8.6	6.4e-18	0.38	0.08	0.69	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHRNA3	0.03	0.03	blup	44	0.03	1.4e-04	-7.32	-8.6	1.2e-17	-0.65	0.55	0.26	FALSE
4	CommonMind	Brain Pre-frontal Cortex	WDR61	0.12	0.02	blup	404	0.06	7.4e-08	0.77	-8.5	2.1e-17	-0.47	0.57	0.34	FALSE
23	GTEx	Breast Mammary Tissue (Male)	CHRNA5	0.40	0.04	lasso	16	0.11	1.6e-03	-6.95	-8.4	4.9e-17	-0.56	0.10	0.44	FALSE
3	CommonMind	Brain Pre-frontal Cortex	IREB2	0.16	0.17	enet	13	0.18	4.1e-21	-6.99	8.2	3.5e-16	0.49	1.00	0.00	FALSE
10	GTEx	Artery Tibial	CHRNA5	0.19	0.23	enet	18	0.23	3.4e-18	-7.69	-8.1	4.3e-16	-0.57	1.00	0.00	FALSE
44	GTEx	Spleen	ADAMTS7	0.34	0.01	enet	12	0.08	3.7e-03	-11.69	-8.1	5.3e-16	-0.33	0.06	0.07	FALSE
38	GTEx	Nerve Tibial	CHRNA5	0.32	0.48	lasso	5	0.47	4.2e-37	-7.76	-8.1	5.6e-16	-0.59	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHRNA5	0.22	0.33	lasso	7	0.33	3.7e-38	-7.69	-8.0	1.2e-15	-0.59	1.00	0.00	FALSE
41	GTEx	Skin Sun Exposed Lower leg	DNAJA4	0.14	0.02	enet	17	0.05	5.3e-05	-0.95	8.0	1.6e-15	0.34	0.38	0.48	FALSE
28	GTEx	Cells Transformed fibroblasts	CHRNA5	0.31	0.41	enet	20	0.45	5.0e-37	-7.81	-7.9	2.0e-15	-0.59	1.00	0.00	FALSE
20	GTEx	Brain Putamen basal ganglia	CHRNA5	0.42	0.40	lasso	5	0.38	5.7e-10	-7.80	-7.9	2.4e-15	-0.57	0.94	0.02	FALSE
42	GTEx	Skin Sun Exposed Lower leg	CHRNA5	0.19	0.11	lasso	4	0.12	7.1e-10	-7.76	-7.9	3.2e-15	-0.59	1.00	0.00	FALSE
17	GTEx	Brain Hippocampus	CHRNA5	0.36	0.32	lasso	3	0.26	1.0e-06	-7.69	-7.8	5.4e-15	-0.57	0.67	0.02	FALSE
36	GTEx	Muscle Skeletal	CHRNA5	0.43	0.58	lasso	7	0.59	1.4e-71	-7.69	-7.8	5.4e-15	-0.59	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	CHRNA5	0.16	0.20	lasso	6	0.19	1.1e-15	-7.76	-7.8	5.6e-15	-0.58	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AGPHD1	0.13	0.07	enet	11	0.05	9.3e-03	-7.32	7.8	5.6e-15	0.51	0.04	0.23	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNA5	0.16	0.14	lasso	1	0.12	1.9e-06	-7.81	-7.8	5.9e-15	-0.57	0.82	0.12	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	CHRNA5	0.28	0.19	lasso	7	0.18	3.5e-06	-7.80	-7.8	6.2e-15	-0.58	0.60	0.28	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CHRNA5	0.51	0.68	lasso	6	0.68	7.1e-113	-7.79	-7.8	6.4e-15	-0.57	1.00	0.00	FALSE
13	GTEx	Brain Cerebellum	CHRNA5	0.24	0.28	lasso	2	0.25	3.9e-08	-7.80	-7.8	6.4e-15	-0.57	0.96	0.01	FALSE
50	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHRNA5	0.03	0.02	enet	6	0.01	2.4e-02	-7.66	-7.8	7.5e-15	-0.59	0.08	0.35	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	CHRNA5	0.15	0.12	lasso	5	0.11	7.9e-07	-7.69	-7.8	8.6e-15	-0.60	0.95	0.02	FALSE
12	GTEx	Brain Cerebellar Hemisphere	CHRNA5	0.38	0.34	lasso	3	0.36	4.6e-10	-7.69	-7.8	8.9e-15	-0.59	0.99	0.00	FALSE
18	GTEx	Brain Hypothalamus	CHRNA5	0.24	0.19	enet	14	0.17	1.0e-04	-7.69	-7.8	9.4e-15	-0.51	0.30	0.21	FALSE
11	GTEx	Brain Caudate basal ganglia	CHRNA5	0.30	0.19	lasso	6	0.20	1.6e-06	-7.04	-7.7	9.7e-15	-0.58	0.77	0.07	FALSE
15	GTEx	Brain Cortex	CHRNA5	0.23	0.27	lasso	2	0.24	3.5e-07	-7.69	-7.7	1.5e-14	-0.58	0.79	0.09	FALSE
35	GTEx	Lung	CHRNA5	0.12	0.11	lasso	2	0.09	2.0e-07	-7.69	-7.7	1.5e-14	-0.58	0.99	0.00	FALSE
24	GTEx	Breast Mammary Tissue (Female)	CHRNA5	0.25	0.15	lasso	2	0.15	2.4e-05	-7.65	-7.7	1.6e-14	-0.58	0.51	0.43	FALSE
16	GTEx	Brain Frontal Cortex BA9	CHRNA5	0.59	0.42	enet	13	0.35	5.1e-10	-7.69	-7.6	2.2e-14	-0.56	0.99	0.00	FALSE
31	GTEx	Esophagus Mucosa	CHRNA5	0.22	0.17	lasso	9	0.17	1.0e-11	-7.76	-7.5	5.2e-14	-0.57	0.99	0.01	FALSE
8	GTEx	Artery Coronary	CHRNA5	0.20	0.15	lasso	7	0.10	3.9e-04	-7.04	-7.3	2.3e-13	-0.57	0.37	0.35	FALSE
82	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CHRNA5	0.15	0.11	lasso	4	0.08	2.7e-03	-6.47	-7.3	3.8e-13	-0.58	0.13	0.18	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB4	0.02	0.00	enet	3	0.01	1.3e-02	-7.01	-7.2	5.9e-13	-0.52	0.19	0.03	FALSE
37	GTEx	Nerve Tibial	PSMA4	0.09	0.05	lasso	2	0.03	3.8e-03	-7.65	7.0	2.7e-12	0.55	0.55	0.05	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNA3	0.02	0.02	lasso	2	0.02	3.1e-03	-6.47	-6.9	6.8e-12	-0.55	0.05	0.06	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	CHRNA5	0.36	0.32	lasso	5	0.32	3.0e-09	-7.69	-6.6	4.2e-11	-0.52	0.88	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADAMTS7	0.08	0.04	enet	8	0.03	4.1e-04	-6.58	6.6	5.3e-11	0.40	0.80	0.02	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MORF4L1	0.04	0.03	lasso	2	0.03	5.8e-04	7.78	6.5	6.7e-11	0.24	0.00	0.96	FALSE
33	GTEx	Heart Left Ventricle	CHRNA5	0.33	0.41	lasso	8	0.42	8.0e-24	-7.80	-6.5	1.0e-10	-0.51	1.00	0.00	FALSE
39	GTEx	Ovary	ADAMTS7	0.31	0.01	enet	1	-0.01	7.8e-01	-6.03	6.0	1.6e-09	0.50	0.07	0.09	FALSE
46	METSIM	Adipose	CHRNA5	0.13	0.19	enet	21	0.20	1.0e-28	-7.79	-5.7	1.3e-08	-0.48	1.00	0.00	FALSE
21	GTEx	Brain Putamen basal ganglia	RP11-762H8.1	0.29	0.07	lasso	4	0.02	1.1e-01	-5.60	-5.7	1.6e-08	-0.19	0.06	0.06	FALSE
14	GTEx	Brain Cortex	ADAMTS7	0.57	-0.01	enet	20	0.04	3.7e-02	0.39	5.5	5.0e-08	0.20	0.06	0.05	FALSE
27	GTEx	Cells Transformed fibroblasts	IREB2	0.19	0.08	lasso	8	0.07	7.0e-06	-3.50	5.4	5.6e-08	0.30	0.78	0.04	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	RP11-762H8.2	0.24	0.05	enet	18	0.11	1.8e-04	-0.79	-5.4	6.8e-08	-0.31	0.10	0.23	FALSE