Hub : Genes

AGPHD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.046	0.0200	0.00630	0.008	0.016	-0.002	0.015	0.000	0.0340	0.00380	6.6e-01	0.0054	0.35000
2	TCGA	Prostate Adenocarcinoma	0.116	0.0675	0.00049	0.012	0.034	0.060	NA	0.028	0.0190	0.00018	6.5e-07	NA	0.00059
3	TCGA	Testicular Germ Cell Tumors	0.134	0.0900	0.00300	0.067	0.044	0.047	NA	0.032	0.0022	0.01100	9.3e-03	NA	0.02700

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.0	1.6	2.9	-1.7	0.3	-1.3
Bipolar Disorder or Schizophrenia	1.4	3.3	5.6	-2.4	-1.5	-1.5
Depressed Affect (Nagel 2018)	1.2	2.6	5.3	0.9	-1.3	2.3
Depression (Nagel 2018)	0.7	1.0	1.8	0.6	-0.9	1.3
Intelligence (Savage-Jansen 2018)	3.4	10.6	15.3	-3.9	2.8	-2.9
Neuroticism (Nagel 2018)	0.4	1.0	1.7	0.7	-0.8	1.3
Schizophrenia (2018)	1.1	2.3	3.2	-1.6	-1.0	-1.8
Schizophrenia vs Biploar Disorder	0.4	0.5	1.5	0.1	-0.3	-1.2
Worry (Nagel 2018)	0.5	1.0	1.5	0.7	-1.1	1.2
Alzheimer’s Disease (in mother)	1.9	2.2	3.2	-1.8	-1.7	0.7
Alzheimer’s Disease (in father)	0.4	0.4	0.7	0.8	0.4	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	-1.0	-0.1	-0.3
Crohns Disease (2017)	0.3	0.6	1.7	-1.3	0.4	0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	-0.7	-0.6	0.4
Ulcerative Colitis (UC)	0.2	0.3	0.5	-0.7	-0.6	-0.3
Major Depression (MDD)	1.4	1.7	3.2	0.1	1.8	-1.3
Reaction Time	6.4	12.2	17.3	2.7	-3.5	4.2
Verbal and Numeric Reasoning (VNR)	1.2	3.0	7.7	-2.8	0.7	-0.9
Breast Cancer	0.5	1.3	1.6	-1.0	1.2	-1.3
Ovarian Cancer	0.1	0.1	0.3	-0.2	0.6	-0.1
Prostate Cancer	0.7	1.0	2.0	-0.8	0.5	-1.4
Age at First Birth	0.1	0.2	0.4	-0.1	0.6	0.3
Bipolar Disorder (2011)	0.5	0.5	1.3	1.2	0.1	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.1	0.4	-0.3	0.2
Coronary Artery Disease (CAD)	1.3	1.5	4.4	2.1	0.1	-0.4
Crohns Disease (2012)	0.6	1.0	1.8	-1.0	1.3	-0.5
Mean Putamen Volume	0.2	0.3	0.5	0.4	0.4	0.7
Fasting Glucose	0.2	0.2	0.4	-0.2	0.6	-0.6
HbA1C	0.3	0.3	0.6	0.4	0.5	0.8
HDL Cholesterol	0.4	0.7	1.5	-0.0	1.2	-0.8
LDL Cholesterol	0.6	1.0	1.7	-1.1	-0.1	1.3
Lupus	0.5	0.7	1.1	-1.1	0.9	-0.3
Neuroticism (2016)	0.5	0.7	1.3	1.1	-0.5	-0.8
Primary Biliary Cirrhosis	0.5	0.7	1.3	-0.6	1.1	0.5
Rheumatoid Arthritis	0.9	1.2	2.7	-0.8	1.6	-0.6
Schizophrenia (2014)	0.7	1.5	3.3	-0.6	-0.9	-1.8
Triglycerides	0.7	1.1	2.9	-0.2	-0.7	1.7
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.0	-0.3	1.5	-1.7
Ulcerative Colitis	0.1	0.1	0.2	-0.1	-0.5	-0.4
Blood Eosinophil Count	0.0	0.3	0.6	0.5	0.1	0.8
Blood Platelet Count	0.2	2.6	4.9	2.2	0.4	1.6
Blood Red Count	0.2	2.3	5.7	-1.0	0.6	-2.4
Blood White Count	0.1	0.6	1.3	1.1	-0.6	-0.0
Heel T-Score	0.0	0.1	0.3	-0.5	0.2	-0.0
BMI	0.9	5.3	6.7	-2.4	1.9	-2.6
Height	0.1	2.4	4.1	1.0	1.4	-2.0
Waist Hip Ratio (WHR)	0.6	2.9	4.7	2.2	0.2	2.0
Systolic Blood Pressure	0.3	1.5	4.1	2.0	-0.2	-0.5
Smoking Status	3.5	8.4	10.7	-2.7	2.7	-3.3
Allergy or Eczema	0.1	0.2	0.5	0.7	-0.4	0.2
Cardiovascular Disease	0.1	0.2	0.5	-0.2	0.7	0.1
Hypothyroidism (self reported)	0.3	0.6	1.3	0.1	-0.6	1.1
Respiratory disease	0.9	1.9	5.3	0.4	-0.5	2.3
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.3	-0.6	0.1	-0.0
Lung FEV1/FVC ratio	0.3	1.8	2.7	-1.1	1.2	-1.6
Lung FVC	1.7	8.7	14.7	-1.7	3.8	-3.0
Neuroticism	1.8	4.2	7.4	1.8	-1.4	2.7
Chronotype (morning person)	0.9	2.1	3.8	-1.9	1.3	-0.9
Hair Pigment	0.1	2.5	2.9	1.7	-1.7	1.4
Tanning	0.0	0.6	1.6	-1.3	-0.4	0.2
Hand grip strength (left)	0.4	1.1	2.3	1.5	-0.9	0.3
Number of treatments/medications taken	1.3	2.3	4.1	0.1	2.0	-1.6
Average weekly spirits intake	1.2	1.5	3.9	-0.7	2.0	-0.4
Sensitivity / hurt feelings	0.3	0.4	0.7	-0.0	-0.9	-0.8
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	0.3	-0.7	0.1
Hearing difficulty/problems: Yes	1.2	1.9	5.0	2.2	-0.5	0.6
Relative age of first facial hair	1.1	2.2	4.5	0.0	2.1	-1.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.5	-0.1	0.0	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	-0.5	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.3	0.5	-0.6
Systolic blood pressure, automated reading	0.7	1.9	5.7	2.4	-0.2	0.3
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.3	-1.8	0.5	-0.1
Angina	1.7	2.2	3.1	1.7	1.8	-0.8
Medication for hormone replacement therapy	0.3	0.4	0.6	0.8	-0.2	0.7
Vitamin and mineral supplements	1.7	2.3	3.9	-2.0	-1.3	1.2
Supplements: Zinc	5.9	6.4	10.4	-0.9	2.8	-3.2
Medication: Co-codamol	1.7	1.9	3.9	-0.3	2.0	-1.3
Medication: Metformin	0.5	0.6	1.1	-1.1	0.5	-0.7
Diabetes (father)	0.8	1.0	1.1	1.0	-1.0	1.0
Diabetes (mother)	1.4	1.8	4.8	0.1	2.2	-0.9
Severe depression (siblings)	0.5	0.5	1.5	0.2	-0.3	-1.2
Pack years adult smoking proportion	34.2	52.2	92.4	-1.8	-9.6	7.8
Impedance of leg (right)	0.9	4.1	6.4	2.1	-1.4	2.5
Leg fat-free mass (left)	1.1	5.9	12.3	-1.9	1.2	-3.5
Trunk fat percentage	0.4	1.8	3.2	-0.2	1.8	-1.4
Hand grip strength (right)	0.3	0.7	0.9	0.9	-0.8	-0.9
Townsend deprivation index at recruitment	0.3	0.5	1.1	-1.1	-0.2	-0.5
Current tobacco smoking	2.0	3.3	8.8	-3.0	-0.4	-1.0
Average weekly fortified wine intake	1.8	2.2	3.3	1.8	-0.7	1.6
Maternal smoking around birth	1.8	2.5	3.7	-1.8	-0.8	-1.9
Fed-up feelings	0.9	1.6	2.2	0.8	-1.4	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.8	-0.9	0.3	0.4
Relative age voice broke	0.1	0.1	0.2	0.2	-0.4	-0.3
Taking other prescription medications	1.2	1.8	4.3	0.1	1.0	-2.1
Age when periods started (menarche)	0.7	1.7	1.9	1.3	1.4	-1.2
Bilateral oophorectomy (both ovaries removed)	3.4	3.9	6.7	-0.6	2.2	-2.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.8	-0.7	-1.3	-0.1
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	3.3	-1.8	-0.1	-1.4
Qualifications: CSEs or equivalent	1.8	2.3	4.7	-1.3	-2.2	0.9
Serious illness, injury or assault to yourself	1.1	1.3	3.7	-0.6	0.0	-1.9
High blood pressure	0.2	0.4	1.0	0.5	0.2	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.9	1.0	-0.5	-0.3
Multivitamins +/- minerals	1.7	2.2	5.1	2.3	0.0	-1.1
Stomach or abdominal pain in last month	0.9	1.1	2.0	0.7	0.9	-1.4
Supplements: Glucosamine	1.0	1.3	2.7	0.3	1.7	-1.0
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.1	1.3	-2.0	0.3
Medication: Atenolol	1.3	1.6	2.8	0.4	1.4	-1.7
Medication: Levothyroxine sodium	0.2	0.3	0.5	-0.7	-0.1	0.7
Sitting height	0.5	3.9	10.6	0.3	1.0	-3.2
Chronic bronchitis/emphysema (father)	6.7	7.8	13.6	-1.3	-2.8	3.7
High blood pressure (mother)	0.3	0.4	0.6	0.4	0.6	0.8
Body mass index (BMI)	0.8	3.5	4.7	-1.5	1.9	-2.2
Impedance of leg (left)	1.3	6.4	10.3	2.6	-1.4	3.2
Leg predicted mass (left)	1.0	5.5	11.5	-1.9	1.1	-3.4
Trunk fat mass	0.7	2.9	4.5	-0.5	2.0	-2.1
Waist circumference	1.1	4.0	5.8	-1.0	2.4	-2.3
Number of incorrect matches in round	2.6	4.2	6.9	2.6	-0.9	2.2
Past tobacco smoking	3.2	5.9	6.9	2.0	-2.6	2.6
Alcohol usually taken with meals	0.7	1.1	2.1	1.5	-0.9	0.5
Nervous feelings	0.2	0.3	0.5	-0.1	-0.6	0.7
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.5	1.0	-2.3	1.1
Hearing difficulty/problems with background noise	0.4	0.7	1.5	1.2	-0.1	0.7
Hair/balding pattern: Pattern 2	1.1	1.4	1.7	-1.2	-1.3	-0.9
Had menopause	0.4	0.5	0.8	-0.9	0.7	0.5
Had other major operations	2.1	2.6	5.7	-0.3	1.4	-2.4
Forced vital capacity (FVC)	1.2	4.5	8.0	-0.3	2.3	-2.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.2	-1.8	-1.3	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	0.8	0.9	-0.7	-0.9
Qualifications: None of the above	0.9	1.9	3.3	1.8	1.5	-0.6
Financial difficulties in last 2 years	0.8	1.1	3.0	-0.4	0.5	-1.7
Mouth/teeth dental problems	0.2	0.3	0.6	0.6	-0.3	0.8
Heart attack	0.5	0.6	1.7	1.3	-0.1	0.1
Allergy	0.2	0.5	0.8	-0.5	0.9	-0.6
Pain all over the body in last month	0.7	0.7	1.7	-1.3	-0.7	-0.3
Diabetes (self-reported)	0.1	0.2	0.3	-0.6	0.0	-0.4
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	7.2	0.2	2.7	-1.2
Medication: Ramipril	0.8	1.0	1.4	-0.9	1.0	-1.2
Medication: Simvastatin	0.3	0.4	0.7	-0.8	0.6	-0.5
Fluid intelligence score	1.5	3.2	9.0	-3.0	-0.3	-0.6
Illnesses of siblings	0.1	0.1	0.3	0.1	0.5	-0.2
Neuroticism score	0.7	1.5	2.1	1.5	-1.2	1.0
Weight	1.0	4.9	9.2	-1.3	1.9	-3.0
Impedance of arm (right)	0.2	0.9	1.5	1.1	0.0	1.2
Arm fat percentage (right)	0.6	2.4	3.8	-0.8	1.9	-1.6
Trunk fat-free mass	0.6	3.6	8.0	-1.2	1.3	-2.8
Hip circumference	1.9	8.0	12.7	-2.5	2.3	-3.6
Time employed in main current job	0.0	0.0	0.1	0.3	0.2	-0.0
Alcohol intake versus 10 years previously	1.4	2.0	3.8	0.0	1.9	-1.5
Father’s age at death	5.6	7.5	12.8	-0.8	3.6	-3.0
Worrier / anxious feelings	0.4	0.8	2.1	1.4	-0.5	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.3	-0.4	-0.6	-0.4
Falls in the last year	8.6	11.6	19.3	-2.7	2.9	-4.4
Hair/balding pattern: Pattern 3	2.2	3.2	5.3	1.8	-1.0	2.3
Number of live births	0.1	0.2	0.3	0.2	0.5	-0.6
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	8.6	-0.5	2.5	-2.9
Pulse rate	1.2	2.0	3.7	0.3	-1.9	1.5
Happiness	1.3	1.6	3.9	2.0	-0.2	0.9
Noisy workplace	0.4	0.6	1.4	1.2	0.0	-0.5
Qualifications: A levels/AS levels or equivalent	1.2	2.7	4.5	2.1	-0.4	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.1	0.2	-0.3	-2.0
Mouth/teeth dental problems: Dentures	1.3	2.2	4.4	-1.3	-2.1	0.8
Asthma	0.7	1.4	3.2	0.7	-0.8	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	1.1	0.5	-0.1
Medication: Cholesterol lowering	0.8	1.3	3.1	-0.5	1.8	-0.7
Depression (self-reported)	0.5	0.6	1.4	-0.5	1.2	0.3
Medication: Lansoprazole	0.7	0.8	2.3	-1.5	0.0	0.5
Prospective memory result	2.1	2.6	6.5	2.5	0.4	1.1
Lung cancer (father)	6.4	7.5	10.2	-2.6	-3.2	2.3
Illnesses of mother	0.0	0.0	0.0	0.1	-0.1	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	10.9	-0.9	3.1	-3.3
Pulse wave Arterial Stiffness index	0.9	1.0	2.0	0.6	0.8	-1.4
Impedance of arm (left)	0.3	1.3	2.4	1.0	-0.8	1.6
Arm fat mass (right)	0.7	2.7	4.1	-1.0	1.7	-2.0
Trunk predicted mass	0.6	3.5	7.5	-1.1	1.2	-2.7
Standing height	0.2	1.6	4.3	0.6	0.6	-2.1
Length of working week for main job	1.0	1.1	3.1	1.8	-0.4	-0.3
Exposure to tobacco smoke at home	0.3	0.4	0.6	0.7	0.8	-0.2
Breastfed as a baby	1.0	1.2	1.6	-1.0	1.0	-1.3
Tense / ‘highly strung’	1.2	2.0	3.1	1.4	-1.8	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.1	0.1	-0.7
Hair/balding pattern: Pattern 4	0.2	0.6	1.0	-1.0	0.2	0.8
Birth weight of first child	1.3	2.4	6.7	-0.3	0.6	-2.6
Peak expiratory flow (PEF)	0.4	1.0	1.8	-0.4	1.0	-1.3
Pulse wave reflection index	0.4	0.5	1.4	-0.4	0.3	-1.2
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.3	0.9	-0.8	1.5
Loud music exposure frequency	0.8	0.9	1.9	-0.2	1.4	-0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	-1.1	-0.4	0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.8	0.8	-0.3
Blood clot in the leg (DVT)	2.9	3.8	7.5	-0.9	1.8	-2.7
Medication: Paracetamol	0.1	0.2	0.4	-0.2	0.3	-0.7
Headache pain in last month	1.4	2.5	4.9	-1.0	1.2	-2.2
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.3	0.6	-1.1	1.1
Glaucoma (self-reported)	0.1	0.1	0.2	-0.1	-0.2	0.5
Gout (self-reported)	0.5	0.6	1.2	1.1	0.0	0.8
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.3	-0.2	0.3
Medication: Amlodipine	0.1	0.2	0.5	-0.2	0.7	-0.1
Medication: Ventolin 100micrograms inhaler	1.4	1.8	2.9	-0.8	-1.7	1.3
Birth weight	0.9	1.9	2.8	1.6	0.3	-1.7
Chronic bronchitis/emphysema (mother)	6.3	7.4	10.6	-1.7	-3.3	2.9
High blood pressure (siblings)	0.0	0.1	0.1	0.2	0.4	-0.0
Forced vital capacity (FVC), Best measure	1.7	6.2	10.7	-0.8	2.7	-3.3
Body fat percentage	0.6	2.3	3.7	-0.6	1.9	-1.7
Leg fat percentage (right)	0.7	2.5	3.9	-0.9	2.0	-1.7
Arm fat-free mass (right)	0.5	2.6	5.7	-1.4	0.5	-2.4
Exposure to tobacco smoke outside home	0.9	1.2	2.7	0.3	1.0	-1.6
Comparative body size at age 10	0.2	0.5	1.1	-1.1	0.6	-0.4
Number of full brothers	0.2	0.3	0.5	-0.0	-0.5	0.7
Worry too long after embarrassment	0.2	0.3	0.6	-0.5	0.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.5	0.6	0.1	-1.6
Wheeze or whistling in the chest in last year	2.9	5.2	9.4	-0.4	-2.5	3.1
Number of children fathered	1.0	1.1	2.1	1.5	-0.9	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.4	-0.1	-0.5	1.9
Age at first live birth	0.3	0.5	1.0	0.4	-1.0	0.6
Pulse wave peak to peak time	0.9	1.0	2.1	-0.5	-0.9	1.4
Health satisfaction	1.1	1.4	3.8	0.3	-1.9	-0.6
Shortness of breath walking on level ground	0.0	0.0	0.1	0.3	-0.1	-0.1
Qualifications: College or University degree	0.0	0.1	0.1	0.4	0.1	-0.1
Eye problems/disorders: None of the above	1.3	1.5	4.5	2.1	-0.2	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.4	-0.1	0.1	0.6
Emphysema/chronic bronchitis	2.0	2.2	3.3	-1.8	-1.8	0.4
Medication for pain relief, constipation, heartburn	0.6	1.1	1.4	-1.1	-1.2	0.8
Neck or shoulder pain in last month	1.2	1.8	3.6	0.9	0.9	-1.9
Medication: Blood pressure	1.6	2.8	5.1	-1.7	0.6	-2.3
Angina (self-reported)	1.8	2.4	3.2	1.7	1.8	-1.1
Migraine (self-reported)	1.2	1.5	3.5	-1.0	0.2	-1.9
Medication: Ibuprofen	0.8	1.0	2.5	1.6	0.6	-0.1
Medication: Allopurinol	0.1	0.2	0.3	0.3	-0.4	-0.6
Medication: Omeprazole	0.0	0.0	0.0	-0.2	-0.1	0.1
Medication: Seretide 50 evohaler	0.5	0.5	1.3	-1.1	0.4	0.5
Mean time to correctly identify matches	3.8	7.3	10.8	2.4	-2.3	3.3
Heart disease (mother)	2.2	2.6	6.2	2.5	1.3	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.7	4.2	1.7	-2.1	1.0
Whole body fat mass	0.9	3.7	6.0	-1.0	2.0	-2.4
Leg fat mass (right)	0.8	3.3	4.8	-1.1	1.9	-2.2
Arm predicted mass (right)	0.5	2.4	5.5	-1.2	0.4	-2.3
Pulse rate, automated reading	0.5	1.7	3.9	0.1	-1.1	2.0
Alcohol intake frequency.	1.8	4.1	7.1	-2.1	0.8	-2.7
Comparative height size at age 10	0.1	0.5	1.1	-0.4	0.4	-1.1
Number of full sisters	1.1	1.4	1.7	1.3	-1.2	1.0
Suffer from ‘nerves’	0.2	0.3	0.5	-0.1	-0.7	0.7
Overall health rating	0.2	0.4	1.1	-0.2	-1.0	0.0
Chest pain or discomfort	0.4	0.5	1.2	1.1	0.5	-0.2
Had major operations	0.4	0.5	1.1	1.1	0.2	-0.5
Age at last live birth	0.6	0.8	1.8	-1.4	0.7	-0.3
Family relationship satisfaction	0.1	0.2	0.4	0.0	0.7	-0.2
Leg pain on walking	1.9	2.4	4.5	2.1	0.9	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.4	-1.2	-0.6	1.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.2	0.5	-0.0
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	4.1	0.2	0.1	2.0
Medication: Aspirin	1.4	1.8	3.7	-0.2	1.9	-1.3
Supplements: Vitamin C	1.1	1.3	2.0	0.7	1.4	-1.2
Knee pain experienced in last month	1.1	1.7	3.1	0.4	1.4	-1.8
Hypertension (Self-reported)	0.1	0.2	0.4	0.3	0.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.4	-1.6	0.0	-0.8
Illnesses of father: Heart disease	1.3	1.9	4.2	2.0	1.2	-0.2
Illnesses of siblings: Diabetes	0.7	0.8	1.7	0.0	-1.3	0.9
Smoking status: Previous	4.5	6.7	13.1	-0.8	3.6	-2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	4.9	0.1	1.8	-2.2
Whole body fat-free mass	0.8	4.4	9.6	-1.5	1.2	-3.1
Leg fat-free mass (right)	0.9	4.9	10.6	-1.7	1.1	-3.2
Arm fat percentage (left)	0.4	1.7	2.4	-0.9	1.6	-1.4
Average weekly red wine intake	0.9	1.3	2.2	1.5	-0.5	1.2
Handedness (chirality/laterality): Left-handed	1.6	2.0	2.5	-1.6	1.2	-1.4
Mood swings	0.8	1.5	3.2	1.8	-0.7	0.9
Loneliness, isolation	0.3	0.4	0.6	0.7	0.4	-0.8
Long-standing illness, disability or infirmity	0.3	0.5	1.4	0.2	0.1	-1.2
Ever had bowel cancer screening	0.4	0.5	0.8	-0.3	0.9	-0.8
Diabetes diagnosed by doctor	0.7	1.1	2.8	-1.7	-0.3	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.4	-0.0	-0.7	-1.2
Friendships satisfaction	0.5	0.6	1.2	1.1	0.7	0.4
Qualifications: nursing, teaching	0.7	1.1	2.4	0.8	-1.6	0.4
Commuting to job workplace: Walk	0.3	0.3	0.7	-0.8	-0.5	0.1
Eye problems/disorders: Cataract	0.3	0.3	0.6	-0.4	0.8	0.4
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.1	0.9	-1.2	1.5
Medication for cholesterol	0.2	0.4	1.0	1.0	-0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	0.0	1.1	-0.3
Back pain experienced in last month	4.8	7.0	12.7	-1.7	2.4	-3.6
Mineral and other dietary supplements	0.6	0.9	2.0	-1.4	-0.6	0.6
Breast cancer (self-reported)	0.5	0.6	1.4	1.2	-0.6	0.3
Asthma (self-reported)	0.5	1.0	2.7	0.3	-0.6	1.6
Osteoporosis (self-reported)	3.1	3.8	6.2	0.1	2.5	-2.3
Osteoarthritis (self-reported)	1.4	1.8	3.7	-1.9	0.9	-1.0
Medication: Aspirin	1.3	1.7	3.6	0.0	1.9	-1.2
Medication: Gliclazide	0.8	0.9	1.5	-1.0	0.3	-1.2
Illnesses of father: None of the above (group 1)	1.9	2.4	3.9	-2.0	-0.4	-1.8
Smoking status: Current	1.9	3.0	6.7	-2.6	-0.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.1	8.7	13.4	-0.2	3.7	-3.6
Whole body water mass	0.8	4.4	9.9	-1.4	1.2	-3.1
Leg predicted mass (right)	1.0	5.3	10.8	-1.9	1.2	-3.3
Arm fat mass (left)	0.6	2.5	3.8	-1.1	1.6	-2.0
Number of self-reported non-cancer illnesses	1.6	2.7	3.7	-0.9	1.9	-1.9
Average weekly champagne plus white wine intake	0.2	0.2	0.3	0.6	0.5	0.1
Miserableness	0.9	1.6	2.9	0.2	-1.4	1.7
Guilty feelings	0.0	0.0	0.1	0.0	0.3	-0.2
Wears glasses or contact lenses	0.8	0.9	1.9	-1.4	0.7	-0.6
Ever taken oral contraceptive pill	1.0	1.1	2.9	0.1	0.5	-1.7
Hearing aid user	1.4	1.6	3.4	1.8	0.5	1.0
Mother’s age at death	1.0	1.3	2.0	-0.8	1.4	-1.1
Financial situation satisfaction	1.0	1.2	2.5	1.6	-0.9	0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.5	0.7	-0.7	-0.2
Commuting to job workplace: Public transport	1.8	2.2	2.7	1.3	-1.4	1.6
Eye problems/disorders: Glaucoma	1.0	1.1	1.8	-1.4	0.9	-0.8
Medication: Blood pressure	0.2	0.5	1.0	-0.4	-0.4	1.0
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.2	-0.1	1.7	-2.1
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.5	1.9	-0.6	0.8
High cholesterol (Self-reported)	0.6	1.1	2.5	0.6	1.6	0.7
Medication: Bendroflumethiazide	0.2	0.3	0.9	-0.3	-0.1	1.0
Medication: Paracetamol	0.1	0.1	0.2	0.4	0.2	-0.2
Medication: Lisinopril	0.0	0.1	0.1	-0.3	0.3	-0.1
Medication: Atorvastatin	0.3	0.3	0.7	0.2	0.9	-0.4
Illnesses of father: High blood pressure	0.7	0.9	2.7	-0.0	-1.6	0.3
Alcohol drinker status: Never	3.7	4.4	6.1	-2.2	1.5	-2.5
Ever smoked	2.7	4.7	8.4	-0.9	2.9	-2.2
Basal metabolic rate	0.8	4.7	10.0	-1.5	1.4	-3.2
Leg fat percentage (left)	0.6	2.1	4.2	-0.4	2.1	-1.4
Arm fat-free mass (left)	0.7	3.6	8.1	-1.1	1.3	-2.8
Number of operations (self-reported)	0.2	0.2	0.5	0.3	-0.4	-0.7
Average weekly beer plus cider intake	0.6	0.9	2.4	0.3	-1.6	0.3
Irritability	0.3	0.6	0.7	0.7	0.7	0.8
Risk taking	0.8	1.1	2.2	1.5	1.0	0.2
Ever had prostate specific antigen (PSA) test	1.1	1.2	1.4	-1.0	1.1	-1.2
Fractured/broken bones in last 5 years	0.5	0.7	1.3	-0.5	-0.7	-1.1
Age started oral contraceptive pill	0.6	0.7	1.2	-0.6	0.7	-1.1
Diastolic blood pressure, automated reading	0.5	1.6	3.8	-2.0	-1.0	-0.3
Ever depressed for a whole week	0.1	0.1	0.1	0.3	0.2	0.4
Unable to work because of sickness or disability	1.6	2.1	3.4	-1.8	-1.0	-1.3
Commuting to job workplace: Cycle	0.3	0.4	0.7	-0.7	0.3	-0.8
Myopia	2.4	3.4	6.7	-0.5	2.6	-1.8
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.8	-0.6	-0.7	1.3
Cholesterol lowering medication	1.3	1.9	2.2	-1.4	1.2	-1.5
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-0.6	-1.1	0.3
Pain experienced in last month	5.0	8.3	15.5	1.5	-2.7	3.9
Supplements: Calcium	0.3	0.4	0.9	-0.4	0.3	-0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	-0.8	-0.4	0.3
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.1	1.8	-0.4	0.5
Deep venous thrombosis (DVT) (self-reported)	2.7	3.4	7.3	-0.8	1.5	-2.7
Heart disease (siblings)	0.9	1.0	1.6	1.3	1.2	-0.0
Alcohol drinker status: Previous	0.1	0.1	0.2	0.5	-0.1	-0.4
Pack years of smoking	30.9	45.4	80.6	-1.4	-9.0	7.3
Impedance of whole body	0.6	3.3	5.7	1.7	-1.1	2.4
Leg fat mass (left)	0.6	2.5	3.6	-0.7	1.8	-1.9
Arm predicted mass (left)	0.7	3.7	8.2	-1.2	1.2	-2.9