Hub : Genes

AGPHD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.046 0.0200 0.00630 0.008 0.016 -0.002 0.015 0.000 0.0340 0.00380 6.6e-01 0.0054 0.35000
2 TCGA Prostate Adenocarcinoma 0.116 0.0675 0.00049 0.012 0.034 0.060 NA 0.028 0.0190 0.00018 6.5e-07 NA 0.00059
3 TCGA Testicular Germ Cell Tumors 0.134 0.0900 0.00300 0.067 0.044 0.047 NA 0.032 0.0022 0.01100 9.3e-03 NA 0.02700

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 1.0 1.6 2.9 -1.7 0.3 -1.3
Bipolar Disorder or Schizophrenia 1.4 3.3 5.6 -2.4 -1.5 -1.5
Depressed Affect (Nagel 2018) 1.2 2.6 5.3 0.9 -1.3 2.3
Depression (Nagel 2018) 0.7 1.0 1.8 0.6 -0.9 1.3
Intelligence (Savage-Jansen 2018) 3.4 10.6 15.3 -3.9 2.8 -2.9
Neuroticism (Nagel 2018) 0.4 1.0 1.7 0.7 -0.8 1.3
Schizophrenia (2018) 1.1 2.3 3.2 -1.6 -1.0 -1.8
Schizophrenia vs Biploar Disorder 0.4 0.5 1.5 0.1 -0.3 -1.2
Worry (Nagel 2018) 0.5 1.0 1.5 0.7 -1.1 1.2
Alzheimer’s Disease (in mother) 1.9 2.2 3.2 -1.8 -1.7 0.7
Alzheimer’s Disease (in father) 0.4 0.4 0.7 0.8 0.4 -0.6
Alzheimer’s Disease (including proxy) 0.3 0.4 1.0 -1.0 -0.1 -0.3
Crohns Disease (2017) 0.3 0.6 1.7 -1.3 0.4 0.2
Irritable Bowel Disease (IBD) 0.1 0.3 0.4 -0.7 -0.6 0.4
Ulcerative Colitis (UC) 0.2 0.3 0.5 -0.7 -0.6 -0.3
Major Depression (MDD) 1.4 1.7 3.2 0.1 1.8 -1.3
Reaction Time 6.4 12.2 17.3 2.7 -3.5 4.2
Verbal and Numeric Reasoning (VNR) 1.2 3.0 7.7 -2.8 0.7 -0.9
Breast Cancer 0.5 1.3 1.6 -1.0 1.2 -1.3
Ovarian Cancer 0.1 0.1 0.3 -0.2 0.6 -0.1
Prostate Cancer 0.7 1.0 2.0 -0.8 0.5 -1.4
Age at First Birth 0.1 0.2 0.4 -0.1 0.6 0.3
Bipolar Disorder (2011) 0.5 0.5 1.3 1.2 0.1 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.1 0.4 -0.3 0.2
Coronary Artery Disease (CAD) 1.3 1.5 4.4 2.1 0.1 -0.4
Crohns Disease (2012) 0.6 1.0 1.8 -1.0 1.3 -0.5
Mean Putamen Volume 0.2 0.3 0.5 0.4 0.4 0.7
Fasting Glucose 0.2 0.2 0.4 -0.2 0.6 -0.6
HbA1C 0.3 0.3 0.6 0.4 0.5 0.8
HDL Cholesterol 0.4 0.7 1.5 -0.0 1.2 -0.8
LDL Cholesterol 0.6 1.0 1.7 -1.1 -0.1 1.3
Lupus 0.5 0.7 1.1 -1.1 0.9 -0.3
Neuroticism (2016) 0.5 0.7 1.3 1.1 -0.5 -0.8
Primary Biliary Cirrhosis 0.5 0.7 1.3 -0.6 1.1 0.5
Rheumatoid Arthritis 0.9 1.2 2.7 -0.8 1.6 -0.6
Schizophrenia (2014) 0.7 1.5 3.3 -0.6 -0.9 -1.8
Triglycerides 0.7 1.1 2.9 -0.2 -0.7 1.7
Type 2 Diabetes (T2D) (2012) 1.6 1.8 3.0 -0.3 1.5 -1.7
Ulcerative Colitis 0.1 0.1 0.2 -0.1 -0.5 -0.4
Blood Eosinophil Count 0.0 0.3 0.6 0.5 0.1 0.8
Blood Platelet Count 0.2 2.6 4.9 2.2 0.4 1.6
Blood Red Count 0.2 2.3 5.7 -1.0 0.6 -2.4
Blood White Count 0.1 0.6 1.3 1.1 -0.6 -0.0
Heel T-Score 0.0 0.1 0.3 -0.5 0.2 -0.0
BMI 0.9 5.3 6.7 -2.4 1.9 -2.6
Height 0.1 2.4 4.1 1.0 1.4 -2.0
Waist Hip Ratio (WHR) 0.6 2.9 4.7 2.2 0.2 2.0
Systolic Blood Pressure 0.3 1.5 4.1 2.0 -0.2 -0.5
Smoking Status 3.5 8.4 10.7 -2.7 2.7 -3.3
Allergy or Eczema 0.1 0.2 0.5 0.7 -0.4 0.2
Cardiovascular Disease 0.1 0.2 0.5 -0.2 0.7 0.1
Hypothyroidism (self reported) 0.3 0.6 1.3 0.1 -0.6 1.1
Respiratory disease 0.9 1.9 5.3 0.4 -0.5 2.3
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.3 -0.6 0.1 -0.0
Lung FEV1/FVC ratio 0.3 1.8 2.7 -1.1 1.2 -1.6
Lung FVC 1.7 8.7 14.7 -1.7 3.8 -3.0
Neuroticism 1.8 4.2 7.4 1.8 -1.4 2.7
Chronotype (morning person) 0.9 2.1 3.8 -1.9 1.3 -0.9
Hair Pigment 0.1 2.5 2.9 1.7 -1.7 1.4
Tanning 0.0 0.6 1.6 -1.3 -0.4 0.2
Hand grip strength (left) 0.4 1.1 2.3 1.5 -0.9 0.3
Number of treatments/medications taken 1.3 2.3 4.1 0.1 2.0 -1.6
Average weekly spirits intake 1.2 1.5 3.9 -0.7 2.0 -0.4
Sensitivity / hurt feelings 0.3 0.4 0.7 -0.0 -0.9 -0.8
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.5 0.3 -0.7 0.1
Hearing difficulty/problems: Yes 1.2 1.9 5.0 2.2 -0.5 0.6
Relative age of first facial hair 1.1 2.2 4.5 0.0 2.1 -1.4
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.5 -0.1 0.0 -0.7
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 -0.3 -0.5 0.4
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 0.3 0.5 -0.6
Systolic blood pressure, automated reading 0.7 1.9 5.7 2.4 -0.2 0.3
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 3.3 -1.8 0.5 -0.1
Angina 1.7 2.2 3.1 1.7 1.8 -0.8
Medication for hormone replacement therapy 0.3 0.4 0.6 0.8 -0.2 0.7
Vitamin and mineral supplements 1.7 2.3 3.9 -2.0 -1.3 1.2
Supplements: Zinc 5.9 6.4 10.4 -0.9 2.8 -3.2
Medication: Co-codamol 1.7 1.9 3.9 -0.3 2.0 -1.3
Medication: Metformin 0.5 0.6 1.1 -1.1 0.5 -0.7
Diabetes (father) 0.8 1.0 1.1 1.0 -1.0 1.0
Diabetes (mother) 1.4 1.8 4.8 0.1 2.2 -0.9
Severe depression (siblings) 0.5 0.5 1.5 0.2 -0.3 -1.2
Pack years adult smoking proportion 34.2 52.2 92.4 -1.8 -9.6 7.8
Impedance of leg (right) 0.9 4.1 6.4 2.1 -1.4 2.5
Leg fat-free mass (left) 1.1 5.9 12.3 -1.9 1.2 -3.5
Trunk fat percentage 0.4 1.8 3.2 -0.2 1.8 -1.4
Hand grip strength (right) 0.3 0.7 0.9 0.9 -0.8 -0.9
Townsend deprivation index at recruitment 0.3 0.5 1.1 -1.1 -0.2 -0.5
Current tobacco smoking 2.0 3.3 8.8 -3.0 -0.4 -1.0
Average weekly fortified wine intake 1.8 2.2 3.3 1.8 -0.7 1.6
Maternal smoking around birth 1.8 2.5 3.7 -1.8 -0.8 -1.9
Fed-up feelings 0.9 1.6 2.2 0.8 -1.4 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.3 0.8 -0.9 0.3 0.4
Relative age voice broke 0.1 0.1 0.2 0.2 -0.4 -0.3
Taking other prescription medications 1.2 1.8 4.3 0.1 1.0 -2.1
Age when periods started (menarche) 0.7 1.7 1.9 1.3 1.4 -1.2
Bilateral oophorectomy (both ovaries removed) 3.4 3.9 6.7 -0.6 2.2 -2.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.8 -0.7 -1.3 -0.1
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.3 -1.8 -0.1 -1.4
Qualifications: CSEs or equivalent 1.8 2.3 4.7 -1.3 -2.2 0.9
Serious illness, injury or assault to yourself 1.1 1.3 3.7 -0.6 0.0 -1.9
High blood pressure 0.2 0.4 1.0 0.5 0.2 -1.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.9 1.0 -0.5 -0.3
Multivitamins +/- minerals 1.7 2.2 5.1 2.3 0.0 -1.1
Stomach or abdominal pain in last month 0.9 1.1 2.0 0.7 0.9 -1.4
Supplements: Glucosamine 1.0 1.3 2.7 0.3 1.7 -1.0
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 4.1 1.3 -2.0 0.3
Medication: Atenolol 1.3 1.6 2.8 0.4 1.4 -1.7
Medication: Levothyroxine sodium 0.2 0.3 0.5 -0.7 -0.1 0.7
Sitting height 0.5 3.9 10.6 0.3 1.0 -3.2
Chronic bronchitis/emphysema (father) 6.7 7.8 13.6 -1.3 -2.8 3.7
High blood pressure (mother) 0.3 0.4 0.6 0.4 0.6 0.8
Body mass index (BMI) 0.8 3.5 4.7 -1.5 1.9 -2.2
Impedance of leg (left) 1.3 6.4 10.3 2.6 -1.4 3.2
Leg predicted mass (left) 1.0 5.5 11.5 -1.9 1.1 -3.4
Trunk fat mass 0.7 2.9 4.5 -0.5 2.0 -2.1
Waist circumference 1.1 4.0 5.8 -1.0 2.4 -2.3
Number of incorrect matches in round 2.6 4.2 6.9 2.6 -0.9 2.2
Past tobacco smoking 3.2 5.9 6.9 2.0 -2.6 2.6
Alcohol usually taken with meals 0.7 1.1 2.1 1.5 -0.9 0.5
Nervous feelings 0.2 0.3 0.5 -0.1 -0.6 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 5.5 1.0 -2.3 1.1
Hearing difficulty/problems with background noise 0.4 0.7 1.5 1.2 -0.1 0.7
Hair/balding pattern: Pattern 2 1.1 1.4 1.7 -1.2 -1.3 -0.9
Had menopause 0.4 0.5 0.8 -0.9 0.7 0.5
Had other major operations 2.1 2.6 5.7 -0.3 1.4 -2.4
Forced vital capacity (FVC) 1.2 4.5 8.0 -0.3 2.3 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 3.2 -1.8 -1.3 -0.2
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 0.8 0.9 -0.7 -0.9
Qualifications: None of the above 0.9 1.9 3.3 1.8 1.5 -0.6
Financial difficulties in last 2 years 0.8 1.1 3.0 -0.4 0.5 -1.7
Mouth/teeth dental problems 0.2 0.3 0.6 0.6 -0.3 0.8
Heart attack 0.5 0.6 1.7 1.3 -0.1 0.1
Allergy 0.2 0.5 0.8 -0.5 0.9 -0.6
Pain all over the body in last month 0.7 0.7 1.7 -1.3 -0.7 -0.3
Diabetes (self-reported) 0.1 0.2 0.3 -0.6 0.0 -0.4
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 7.2 0.2 2.7 -1.2
Medication: Ramipril 0.8 1.0 1.4 -0.9 1.0 -1.2
Medication: Simvastatin 0.3 0.4 0.7 -0.8 0.6 -0.5
Fluid intelligence score 1.5 3.2 9.0 -3.0 -0.3 -0.6
Illnesses of siblings 0.1 0.1 0.3 0.1 0.5 -0.2
Neuroticism score 0.7 1.5 2.1 1.5 -1.2 1.0
Weight 1.0 4.9 9.2 -1.3 1.9 -3.0
Impedance of arm (right) 0.2 0.9 1.5 1.1 0.0 1.2
Arm fat percentage (right) 0.6 2.4 3.8 -0.8 1.9 -1.6
Trunk fat-free mass 0.6 3.6 8.0 -1.2 1.3 -2.8
Hip circumference 1.9 8.0 12.7 -2.5 2.3 -3.6
Time employed in main current job 0.0 0.0 0.1 0.3 0.2 -0.0
Alcohol intake versus 10 years previously 1.4 2.0 3.8 0.0 1.9 -1.5
Father’s age at death 5.6 7.5 12.8 -0.8 3.6 -3.0
Worrier / anxious feelings 0.4 0.8 2.1 1.4 -0.5 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.3 -0.4 -0.6 -0.4
Falls in the last year 8.6 11.6 19.3 -2.7 2.9 -4.4
Hair/balding pattern: Pattern 3 2.2 3.2 5.3 1.8 -1.0 2.3
Number of live births 0.1 0.2 0.3 0.2 0.5 -0.6
Forced expiratory volume in 1-second (FEV1) 1.5 5.1 8.6 -0.5 2.5 -2.9
Pulse rate 1.2 2.0 3.7 0.3 -1.9 1.5
Happiness 1.3 1.6 3.9 2.0 -0.2 0.9
Noisy workplace 0.4 0.6 1.4 1.2 0.0 -0.5
Qualifications: A levels/AS levels or equivalent 1.2 2.7 4.5 2.1 -0.4 1.9
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 4.1 0.2 -0.3 -2.0
Mouth/teeth dental problems: Dentures 1.3 2.2 4.4 -1.3 -2.1 0.8
Asthma 0.7 1.4 3.2 0.7 -0.8 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.1 1.1 0.5 -0.1
Medication: Cholesterol lowering 0.8 1.3 3.1 -0.5 1.8 -0.7
Depression (self-reported) 0.5 0.6 1.4 -0.5 1.2 0.3
Medication: Lansoprazole 0.7 0.8 2.3 -1.5 0.0 0.5
Prospective memory result 2.1 2.6 6.5 2.5 0.4 1.1
Lung cancer (father) 6.4 7.5 10.2 -2.6 -3.2 2.3
Illnesses of mother 0.0 0.0 0.0 0.1 -0.1 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 7.1 10.9 -0.9 3.1 -3.3
Pulse wave Arterial Stiffness index 0.9 1.0 2.0 0.6 0.8 -1.4
Impedance of arm (left) 0.3 1.3 2.4 1.0 -0.8 1.6
Arm fat mass (right) 0.7 2.7 4.1 -1.0 1.7 -2.0
Trunk predicted mass 0.6 3.5 7.5 -1.1 1.2 -2.7
Standing height 0.2 1.6 4.3 0.6 0.6 -2.1
Length of working week for main job 1.0 1.1 3.1 1.8 -0.4 -0.3
Exposure to tobacco smoke at home 0.3 0.4 0.6 0.7 0.8 -0.2
Breastfed as a baby 1.0 1.2 1.6 -1.0 1.0 -1.3
Tense / ‘highly strung’ 1.2 2.0 3.1 1.4 -1.8 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.5 -0.1 0.1 -0.7
Hair/balding pattern: Pattern 4 0.2 0.6 1.0 -1.0 0.2 0.8
Birth weight of first child 1.3 2.4 6.7 -0.3 0.6 -2.6
Peak expiratory flow (PEF) 0.4 1.0 1.8 -0.4 1.0 -1.3
Pulse wave reflection index 0.4 0.5 1.4 -0.4 0.3 -1.2
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.3 0.9 -0.8 1.5
Loud music exposure frequency 0.8 0.9 1.9 -0.2 1.4 -0.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.3 -1.1 -0.4 0.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.6 0.8 0.8 -0.3
Blood clot in the leg (DVT) 2.9 3.8 7.5 -0.9 1.8 -2.7
Medication: Paracetamol 0.1 0.2 0.4 -0.2 0.3 -0.7
Headache pain in last month 1.4 2.5 4.9 -1.0 1.2 -2.2
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.3 0.6 -1.1 1.1
Glaucoma (self-reported) 0.1 0.1 0.2 -0.1 -0.2 0.5
Gout (self-reported) 0.5 0.6 1.2 1.1 0.0 0.8
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.1 -0.3 -0.2 0.3
Medication: Amlodipine 0.1 0.2 0.5 -0.2 0.7 -0.1
Medication: Ventolin 100micrograms inhaler 1.4 1.8 2.9 -0.8 -1.7 1.3
Birth weight 0.9 1.9 2.8 1.6 0.3 -1.7
Chronic bronchitis/emphysema (mother) 6.3 7.4 10.6 -1.7 -3.3 2.9
High blood pressure (siblings) 0.0 0.1 0.1 0.2 0.4 -0.0
Forced vital capacity (FVC), Best measure 1.7 6.2 10.7 -0.8 2.7 -3.3
Body fat percentage 0.6 2.3 3.7 -0.6 1.9 -1.7
Leg fat percentage (right) 0.7 2.5 3.9 -0.9 2.0 -1.7
Arm fat-free mass (right) 0.5 2.6 5.7 -1.4 0.5 -2.4
Exposure to tobacco smoke outside home 0.9 1.2 2.7 0.3 1.0 -1.6
Comparative body size at age 10 0.2 0.5 1.1 -1.1 0.6 -0.4
Number of full brothers 0.2 0.3 0.5 -0.0 -0.5 0.7
Worry too long after embarrassment 0.2 0.3 0.6 -0.5 0.1 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 2.5 0.6 0.1 -1.6
Wheeze or whistling in the chest in last year 2.9 5.2 9.4 -0.4 -2.5 3.1
Number of children fathered 1.0 1.1 2.1 1.5 -0.9 0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 3.4 -0.1 -0.5 1.9
Age at first live birth 0.3 0.5 1.0 0.4 -1.0 0.6
Pulse wave peak to peak time 0.9 1.0 2.1 -0.5 -0.9 1.4
Health satisfaction 1.1 1.4 3.8 0.3 -1.9 -0.6
Shortness of breath walking on level ground 0.0 0.0 0.1 0.3 -0.1 -0.1
Qualifications: College or University degree 0.0 0.1 0.1 0.4 0.1 -0.1
Eye problems/disorders: None of the above 1.3 1.5 4.5 2.1 -0.2 0.3
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.4 -0.1 0.1 0.6
Emphysema/chronic bronchitis 2.0 2.2 3.3 -1.8 -1.8 0.4
Medication for pain relief, constipation, heartburn 0.6 1.1 1.4 -1.1 -1.2 0.8
Neck or shoulder pain in last month 1.2 1.8 3.6 0.9 0.9 -1.9
Medication: Blood pressure 1.6 2.8 5.1 -1.7 0.6 -2.3
Angina (self-reported) 1.8 2.4 3.2 1.7 1.8 -1.1
Migraine (self-reported) 1.2 1.5 3.5 -1.0 0.2 -1.9
Medication: Ibuprofen 0.8 1.0 2.5 1.6 0.6 -0.1
Medication: Allopurinol 0.1 0.2 0.3 0.3 -0.4 -0.6
Medication: Omeprazole 0.0 0.0 0.0 -0.2 -0.1 0.1
Medication: Seretide 50 evohaler 0.5 0.5 1.3 -1.1 0.4 0.5
Mean time to correctly identify matches 3.8 7.3 10.8 2.4 -2.3 3.3
Heart disease (mother) 2.2 2.6 6.2 2.5 1.3 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.7 4.2 1.7 -2.1 1.0
Whole body fat mass 0.9 3.7 6.0 -1.0 2.0 -2.4
Leg fat mass (right) 0.8 3.3 4.8 -1.1 1.9 -2.2
Arm predicted mass (right) 0.5 2.4 5.5 -1.2 0.4 -2.3
Pulse rate, automated reading 0.5 1.7 3.9 0.1 -1.1 2.0
Alcohol intake frequency. 1.8 4.1 7.1 -2.1 0.8 -2.7
Comparative height size at age 10 0.1 0.5 1.1 -0.4 0.4 -1.1
Number of full sisters 1.1 1.4 1.7 1.3 -1.2 1.0
Suffer from ‘nerves’ 0.2 0.3 0.5 -0.1 -0.7 0.7
Overall health rating 0.2 0.4 1.1 -0.2 -1.0 0.0
Chest pain or discomfort 0.4 0.5 1.2 1.1 0.5 -0.2
Had major operations 0.4 0.5 1.1 1.1 0.2 -0.5
Age at last live birth 0.6 0.8 1.8 -1.4 0.7 -0.3
Family relationship satisfaction 0.1 0.2 0.4 0.0 0.7 -0.2
Leg pain on walking 1.9 2.4 4.5 2.1 0.9 -1.4
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 2.4 -1.2 -0.6 1.6
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 0.2 0.5 -0.0
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 4.1 0.2 0.1 2.0
Medication: Aspirin 1.4 1.8 3.7 -0.2 1.9 -1.3
Supplements: Vitamin C 1.1 1.3 2.0 0.7 1.4 -1.2
Knee pain experienced in last month 1.1 1.7 3.1 0.4 1.4 -1.8
Hypertension (Self-reported) 0.1 0.2 0.4 0.3 0.2 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 2.4 -1.6 0.0 -0.8
Illnesses of father: Heart disease 1.3 1.9 4.2 2.0 1.2 -0.2
Illnesses of siblings: Diabetes 0.7 0.8 1.7 0.0 -1.3 0.9
Smoking status: Previous 4.5 6.7 13.1 -0.8 3.6 -2.5
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.7 4.9 0.1 1.8 -2.2
Whole body fat-free mass 0.8 4.4 9.6 -1.5 1.2 -3.1
Leg fat-free mass (right) 0.9 4.9 10.6 -1.7 1.1 -3.2
Arm fat percentage (left) 0.4 1.7 2.4 -0.9 1.6 -1.4
Average weekly red wine intake 0.9 1.3 2.2 1.5 -0.5 1.2
Handedness (chirality/laterality): Left-handed 1.6 2.0 2.5 -1.6 1.2 -1.4
Mood swings 0.8 1.5 3.2 1.8 -0.7 0.9
Loneliness, isolation 0.3 0.4 0.6 0.7 0.4 -0.8
Long-standing illness, disability or infirmity 0.3 0.5 1.4 0.2 0.1 -1.2
Ever had bowel cancer screening 0.4 0.5 0.8 -0.3 0.9 -0.8
Diabetes diagnosed by doctor 0.7 1.1 2.8 -1.7 -0.3 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.4 -0.0 -0.7 -1.2
Friendships satisfaction 0.5 0.6 1.2 1.1 0.7 0.4
Qualifications: nursing, teaching 0.7 1.1 2.4 0.8 -1.6 0.4
Commuting to job workplace: Walk 0.3 0.3 0.7 -0.8 -0.5 0.1
Eye problems/disorders: Cataract 0.3 0.3 0.6 -0.4 0.8 0.4
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.1 0.9 -1.2 1.5
Medication for cholesterol 0.2 0.4 1.0 1.0 -0.3 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.3 0.0 1.1 -0.3
Back pain experienced in last month 4.8 7.0 12.7 -1.7 2.4 -3.6
Mineral and other dietary supplements 0.6 0.9 2.0 -1.4 -0.6 0.6
Breast cancer (self-reported) 0.5 0.6 1.4 1.2 -0.6 0.3
Asthma (self-reported) 0.5 1.0 2.7 0.3 -0.6 1.6
Osteoporosis (self-reported) 3.1 3.8 6.2 0.1 2.5 -2.3
Osteoarthritis (self-reported) 1.4 1.8 3.7 -1.9 0.9 -1.0
Medication: Aspirin 1.3 1.7 3.6 0.0 1.9 -1.2
Medication: Gliclazide 0.8 0.9 1.5 -1.0 0.3 -1.2
Illnesses of father: None of the above (group 1) 1.9 2.4 3.9 -2.0 -0.4 -1.8
Smoking status: Current 1.9 3.0 6.7 -2.6 -0.2 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.1 8.7 13.4 -0.2 3.7 -3.6
Whole body water mass 0.8 4.4 9.9 -1.4 1.2 -3.1
Leg predicted mass (right) 1.0 5.3 10.8 -1.9 1.2 -3.3
Arm fat mass (left) 0.6 2.5 3.8 -1.1 1.6 -2.0
Number of self-reported non-cancer illnesses 1.6 2.7 3.7 -0.9 1.9 -1.9
Average weekly champagne plus white wine intake 0.2 0.2 0.3 0.6 0.5 0.1
Miserableness 0.9 1.6 2.9 0.2 -1.4 1.7
Guilty feelings 0.0 0.0 0.1 0.0 0.3 -0.2
Wears glasses or contact lenses 0.8 0.9 1.9 -1.4 0.7 -0.6
Ever taken oral contraceptive pill 1.0 1.1 2.9 0.1 0.5 -1.7
Hearing aid user 1.4 1.6 3.4 1.8 0.5 1.0
Mother’s age at death 1.0 1.3 2.0 -0.8 1.4 -1.1
Financial situation satisfaction 1.0 1.2 2.5 1.6 -0.9 0.6
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.5 0.7 -0.7 -0.2
Commuting to job workplace: Public transport 1.8 2.2 2.7 1.3 -1.4 1.6
Eye problems/disorders: Glaucoma 1.0 1.1 1.8 -1.4 0.9 -0.8
Medication: Blood pressure 0.2 0.5 1.0 -0.4 -0.4 1.0
Pain type(s) experienced in last month: Hip pain 1.9 2.4 4.2 -0.1 1.7 -2.1
Supplements: Fish oil (including cod liver oil) 1.2 1.5 3.5 1.9 -0.6 0.8
High cholesterol (Self-reported) 0.6 1.1 2.5 0.6 1.6 0.7
Medication: Bendroflumethiazide 0.2 0.3 0.9 -0.3 -0.1 1.0
Medication: Paracetamol 0.1 0.1 0.2 0.4 0.2 -0.2
Medication: Lisinopril 0.0 0.1 0.1 -0.3 0.3 -0.1
Medication: Atorvastatin 0.3 0.3 0.7 0.2 0.9 -0.4
Illnesses of father: High blood pressure 0.7 0.9 2.7 -0.0 -1.6 0.3
Alcohol drinker status: Never 3.7 4.4 6.1 -2.2 1.5 -2.5
Ever smoked 2.7 4.7 8.4 -0.9 2.9 -2.2
Basal metabolic rate 0.8 4.7 10.0 -1.5 1.4 -3.2
Leg fat percentage (left) 0.6 2.1 4.2 -0.4 2.1 -1.4
Arm fat-free mass (left) 0.7 3.6 8.1 -1.1 1.3 -2.8
Number of operations (self-reported) 0.2 0.2 0.5 0.3 -0.4 -0.7
Average weekly beer plus cider intake 0.6 0.9 2.4 0.3 -1.6 0.3
Irritability 0.3 0.6 0.7 0.7 0.7 0.8
Risk taking 0.8 1.1 2.2 1.5 1.0 0.2
Ever had prostate specific antigen (PSA) test 1.1 1.2 1.4 -1.0 1.1 -1.2
Fractured/broken bones in last 5 years 0.5 0.7 1.3 -0.5 -0.7 -1.1
Age started oral contraceptive pill 0.6 0.7 1.2 -0.6 0.7 -1.1
Diastolic blood pressure, automated reading 0.5 1.6 3.8 -2.0 -1.0 -0.3
Ever depressed for a whole week 0.1 0.1 0.1 0.3 0.2 0.4
Unable to work because of sickness or disability 1.6 2.1 3.4 -1.8 -1.0 -1.3
Commuting to job workplace: Cycle 0.3 0.4 0.7 -0.7 0.3 -0.8
Myopia 2.4 3.4 6.7 -0.5 2.6 -1.8
Vascular/heart problems diagnosed by doctor 0.3 0.9 1.8 -0.6 -0.7 1.3
Cholesterol lowering medication 1.3 1.9 2.2 -1.4 1.2 -1.5
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.3 -0.6 -1.1 0.3
Pain experienced in last month 5.0 8.3 15.5 1.5 -2.7 3.9
Supplements: Calcium 0.3 0.4 0.9 -0.4 0.3 -0.9
Basal cell carcinoma (self-reported) 0.3 0.3 0.7 -0.8 -0.4 0.3
Heart attack/myocardial infarction (self-reported) 0.9 1.1 3.1 1.8 -0.4 0.5
Deep venous thrombosis (DVT) (self-reported) 2.7 3.4 7.3 -0.8 1.5 -2.7
Heart disease (siblings) 0.9 1.0 1.6 1.3 1.2 -0.0
Alcohol drinker status: Previous 0.1 0.1 0.2 0.5 -0.1 -0.4
Pack years of smoking 30.9 45.4 80.6 -1.4 -9.0 7.3
Impedance of whole body 0.6 3.3 5.7 1.7 -1.1 2.4
Leg fat mass (left) 0.6 2.5 3.6 -0.7 1.8 -1.9
Arm predicted mass (left) 0.7 3.7 8.2 -1.2 1.2 -2.9