Hub : Genes

WDR61

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1210	0.0350	1.2e-06	0.018	0.060	0.044	0.053	0.029	2.6e-03	7.4e-08	4.3e-06	4.1e-07	1.5e-04
2	GTEx	Adipose Visceral Omentum	0.1290	0.0530	1.0e-02	0.001	NA	-0.002	NA	0.004	2.7e-01	NA	4.3e-01	NA	1.8e-01
3	YFS	Blood	0.1353	0.0237	0.0e+00	0.109	0.096	0.104	0.106	0.107	1.4e-33	1.4e-29	2.7e-32	7.4e-33	3.2e-33
4	TCGA	Brain Lower Grade Glioma	0.0449	0.0206	6.8e-04	0.004	0.026	0.011	NA	0.015	9.9e-02	5.9e-04	1.7e-02	NA	7.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	2.2	-0.9	1.5	-0.1	-0.6
Bipolar Disorder or Schizophrenia	0.3	0.8	1.2	-0.5	-0.9	-1.1	-0.9
Depressed Affect (Nagel 2018)	0.6	1.2	2.1	0.8	-1.2	0.8	1.4
Depression (Nagel 2018)	0.4	0.6	1.6	0.4	-0.1	1.3	0.7
Intelligence (Savage-Jansen 2018)	1.5	4.8	12.5	-2.5	-0.4	-0.2	-3.5
Neuroticism (Nagel 2018)	1.2	2.7	6.8	2.6	-1.2	0.4	1.6
Schizophrenia (2018)	0.9	1.9	5.5	0.0	-2.3	-1.3	-0.6
Schizophrenia vs Biploar Disorder	1.9	2.5	5.3	2.0	-2.3	0.1	0.8
Worry (Nagel 2018)	1.2	2.4	5.8	2.4	-0.4	-1.0	1.6
Alzheimer’s Disease (in mother)	0.5	0.6	2.2	-1.5	-0.5	0.2	-0.0
Alzheimer’s Disease (in father)	1.5	1.7	2.6	1.0	1.6	-0.7	1.6
Alzheimer’s Disease (including proxy)	0.6	0.8	2.1	-0.0	1.1	0.1	1.4
Crohns Disease (2017)	0.8	1.8	4.7	-1.1	-2.2	-0.2	-1.1
Irritable Bowel Disease (IBD)	0.7	1.8	3.9	-0.5	-2.0	-0.7	-1.6
Ulcerative Colitis (UC)	0.5	0.9	1.8	0.2	-1.1	-0.7	-1.3
Major Depression (MDD)	1.8	2.2	6.8	0.4	-2.6	0.4	-1.2
Reaction Time	0.9	1.7	4.2	-0.8	-2.1	-0.8	1.1
Verbal and Numeric Reasoning (VNR)	1.2	2.9	7.4	-2.7	0.7	1.5	-1.1
Breast Cancer	0.4	0.9	2.0	0.9	-1.4	0.8	-0.4
Ovarian Cancer	0.9	1.2	2.3	1.4	-1.5	-0.4	-0.7
Prostate Cancer	1.5	2.2	6.4	1.2	2.5	-0.7	0.5
Age at First Birth	0.7	1.0	2.0	-0.6	-0.1	-1.4	-1.2
Bipolar Disorder (2011)	1.4	1.3	2.5	0.2	0.8	-1.5	1.6
Body Mass Index (BMI) (2010)	1.4	1.9	5.0	0.4	-0.7	1.5	2.2
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.7	-0.1	0.7	0.2
Crohns Disease (2012)	0.5	0.9	2.0	-0.8	-1.4	0.7	-0.6
Mean Putamen Volume	0.4	0.4	0.8	-0.9	0.1	0.7	-0.6
Fasting Glucose	0.4	0.5	1.2	-1.1	-0.7	-0.2	-0.6
HbA1C	1.0	1.1	1.6	-1.3	0.8	0.8	1.3
HDL Cholesterol	0.4	0.7	2.2	0.5	0.1	-1.5	-0.5
LDL Cholesterol	0.6	1.0	2.5	-0.8	-1.6	0.3	-0.8
Lupus	0.4	0.6	1.5	0.4	-0.9	1.2	-0.0
Neuroticism (2016)	2.2	3.2	8.0	2.8	-1.7	-0.4	1.4
Primary Biliary Cirrhosis	0.8	1.1	2.2	-0.6	-0.6	-1.5	-1.3
Rheumatoid Arthritis	0.2	0.3	0.9	0.6	0.4	-0.9	-0.0
Schizophrenia (2014)	0.6	1.3	2.3	0.9	-1.4	-1.5	0.1
Triglycerides	0.8	1.3	2.7	-1.6	-0.9	1.3	-0.4
Type 2 Diabetes (T2D) (2012)	1.6	1.8	6.5	0.2	0.3	-2.5	-0.8
Ulcerative Colitis	0.6	0.9	2.1	0.7	-1.4	-0.9	-0.4
Blood Eosinophil Count	0.2	1.5	3.5	-1.9	0.7	-0.2	-1.4
Blood Platelet Count	1.5	17.8	49.1	-3.6	-3.0	-0.8	-7.0
Blood Red Count	4.1	39.3	114.5	2.8	-0.9	5.8	10.7
Blood White Count	0.2	1.3	2.5	-1.5	-0.6	-0.3	-1.6
Heel T-Score	0.0	0.4	1.2	0.3	0.4	1.1	0.2
BMI	0.2	1.2	4.4	-0.4	0.2	-0.2	2.1
Height	0.3	5.5	10.1	3.2	-1.5	-2.8	-1.3
Waist Hip Ratio (WHR)	0.4	2.0	5.9	-0.9	-1.0	2.4	0.3
Systolic Blood Pressure	0.3	1.4	3.7	-1.1	1.9	-0.7	-0.1
Smoking Status	0.4	1.0	1.7	0.4	-1.0	1.3	1.1
Allergy or Eczema	0.2	0.4	0.9	1.0	0.8	-0.4	-0.0
Cardiovascular Disease	0.1	0.2	0.4	-0.6	0.5	-0.5	0.1
Hypothyroidism (self reported)	0.3	0.6	1.5	-0.7	0.1	1.2	0.8
Respiratory disease	1.0	2.3	5.5	-2.4	-0.8	-1.1	-1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.6	-1.6	-0.1	-0.0	-1.1
Lung FEV1/FVC ratio	0.7	3.6	11.1	0.9	3.3	0.7	1.3
Lung FVC	0.3	1.4	5.0	2.2	0.4	0.1	-0.7
Neuroticism	0.7	1.7	3.7	1.5	-0.9	-0.3	1.9
Chronotype (morning person)	1.7	3.8	7.4	-2.7	2.7	-0.0	-0.9
Hair Pigment	0.0	0.5	0.7	-0.1	0.9	-0.8	-0.7
Tanning	0.0	0.2	0.5	-0.5	0.1	0.7	-0.2
Hand grip strength (left)	0.8	2.2	3.3	-1.2	1.7	-1.8	-1.0
Number of treatments/medications taken	0.8	1.5	2.7	0.5	-1.0	-1.4	1.6
Average weekly spirits intake	0.9	1.2	3.1	-0.2	-1.1	-0.6	-1.8
Sensitivity / hurt feelings	1.4	2.3	4.2	2.0	0.8	1.0	1.9
Frequency of depressed mood in last 2 weeks	1.2	1.7	2.6	1.0	0.8	1.6	1.6
Hearing difficulty/problems: Yes	1.6	2.4	5.4	1.7	-2.3	0.6	1.0
Relative age of first facial hair	0.7	1.4	3.8	1.0	1.9	0.0	1.1
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.0	0.7	-1.7	-0.7	-0.8
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.7	1.9	-1.0	0.7	1.4
Ever had hysterectomy (womb removed)	1.4	1.6	4.3	0.1	-1.5	0.3	-2.1
Systolic blood pressure, automated reading	0.1	0.4	0.6	0.8	0.6	-0.6	0.3
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	4.3	-1.4	-2.1	0.6	-0.1
Angina	0.7	0.9	2.8	1.7	-0.4	0.9	0.1
Medication for hormone replacement therapy	0.7	0.8	1.2	0.6	-0.8	1.1	0.9
Vitamin and mineral supplements	1.5	2.0	6.0	-2.4	-0.9	1.1	-0.4
Supplements: Zinc	0.9	1.0	2.4	1.5	0.8	-0.8	0.3
Medication: Co-codamol	0.4	0.5	1.1	0.8	0.2	-1.1	0.4
Medication: Metformin	0.4	0.6	1.2	-0.3	0.5	0.8	1.1
Diabetes (father)	0.8	1.0	1.7	-1.3	1.2	0.7	-0.4
Diabetes (mother)	1.2	1.6	3.7	1.6	-1.9	-0.3	0.2
Severe depression (siblings)	0.3	0.3	0.5	0.7	0.6	0.3	-0.7
Pack years adult smoking proportion	12.0	18.2	72.1	-8.5	-0.1	0.8	0.5
Impedance of leg (right)	0.1	0.7	1.5	1.2	-0.4	0.2	0.9
Leg fat-free mass (left)	0.1	0.7	2.3	0.4	0.1	-1.5	0.7
Trunk fat percentage	1.0	3.8	8.5	1.5	-1.4	-1.6	2.9
Hand grip strength (right)	0.9	2.4	5.6	0.2	2.4	-1.9	-0.5
Townsend deprivation index at recruitment	0.8	1.1	3.7	0.0	-1.9	-0.1	0.7
Current tobacco smoking	0.9	1.5	2.7	-1.6	-0.5	1.6	-0.7
Average weekly fortified wine intake	0.5	0.5	1.0	-0.5	-1.0	-0.2	-1.0
Maternal smoking around birth	2.0	2.9	10.8	-0.4	-0.4	-3.3	-0.7
Fed-up feelings	1.0	1.9	3.7	0.9	-1.9	0.4	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	0.9	-0.9	-0.1	0.8	-0.9
Relative age voice broke	0.6	0.9	1.7	1.2	0.8	0.1	1.3
Taking other prescription medications	0.9	1.4	2.6	1.6	-0.3	-0.6	1.5
Age when periods started (menarche)	1.1	2.6	5.9	2.4	-1.0	-1.8	-0.4
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	7.1	2.7	0.2	0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.4	-0.6	0.7	2.3	1.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.5	0.5	1.2	0.6	0.4
Qualifications: CSEs or equivalent	1.1	1.5	2.3	-1.5	0.8	0.9	1.5
Serious illness, injury or assault to yourself	0.8	1.0	1.8	1.2	0.4	0.7	1.3
High blood pressure	0.4	1.0	2.3	1.5	-0.2	-1.0	0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.4	1.0	1.2	-0.0	0.7
Multivitamins +/- minerals	1.1	1.4	4.2	2.0	0.9	-0.9	-0.2
Stomach or abdominal pain in last month	2.2	2.7	5.1	2.3	0.8	-0.8	2.1
Supplements: Glucosamine	0.5	0.7	2.1	1.4	0.3	0.3	-0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.7	2.1	-0.2	-1.5	0.7	-0.2
Medication: Atenolol	0.6	0.7	1.2	1.1	-0.3	1.0	0.8
Medication: Levothyroxine sodium	0.3	0.5	1.8	0.3	-0.5	0.1	1.3
Sitting height	0.6	4.1	7.3	0.4	-1.8	-2.7	-2.4
Chronic bronchitis/emphysema (father)	3.9	4.5	13.6	-3.7	-1.1	-0.1	-1.8
High blood pressure (mother)	1.0	1.4	3.4	-1.9	1.4	0.4	-0.4
Body mass index (BMI)	0.3	1.4	2.9	0.1	-0.9	-1.4	1.7
Impedance of leg (left)	0.1	0.4	0.7	0.8	-0.7	0.3	0.6
Leg predicted mass (left)	0.1	0.7	2.5	0.3	0.0	-1.6	0.5
Trunk fat mass	0.8	3.3	5.6	1.4	-1.2	-2.0	2.4
Waist circumference	0.3	1.2	2.7	0.4	-1.0	-1.0	1.6
Number of incorrect matches in round	0.6	1.0	3.5	-0.1	0.2	-1.9	0.7
Past tobacco smoking	0.2	0.4	0.8	-0.5	0.9	0.0	-0.8
Alcohol usually taken with meals	1.0	1.7	4.8	0.5	2.2	0.7	1.1
Nervous feelings	0.3	0.6	1.7	1.3	-0.3	-0.5	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.2	0.1	1.0	1.1	0.9
Hearing difficulty/problems with background noise	1.8	2.9	6.3	2.5	-1.6	0.2	1.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.9	-0.4	0.0	-0.4	-1.0
Had menopause	0.7	0.9	2.2	0.2	-1.5	1.2	0.2
Had other major operations	0.6	0.7	2.4	1.6	-0.2	0.4	0.5
Forced vital capacity (FVC)	0.5	2.1	3.6	1.9	0.6	-1.4	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	6.5	-0.5	0.1	2.6	0.7
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	3.0	1.7	-1.1	-0.8	-0.0
Qualifications: None of the above	1.7	3.5	5.9	2.3	-2.4	-0.5	1.6
Financial difficulties in last 2 years	1.0	1.4	4.6	2.1	0.3	0.3	0.9
Mouth/teeth dental problems	0.2	0.3	0.7	0.8	0.5	0.5	0.5
Heart attack	0.1	0.2	0.4	-0.1	0.2	-0.5	-0.7
Allergy	0.2	0.4	1.0	-0.1	-1.0	-0.4	-0.6
Pain all over the body in last month	1.0	1.1	3.7	0.4	-0.6	0.5	1.9
Diabetes (self-reported)	0.4	0.6	1.0	-0.7	1.0	0.3	0.9
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.3	1.8	-1.3	-1.2	-0.3
Medication: Ramipril	0.1	0.1	0.2	-0.0	0.5	0.1	-0.2
Medication: Simvastatin	0.5	0.8	2.4	-0.4	-0.5	-1.5	0.5
Fluid intelligence score	2.1	4.3	11.6	-3.4	0.4	2.1	-1.0
Illnesses of siblings	0.4	0.5	1.3	-0.0	1.1	-0.5	-0.8
Neuroticism score	1.5	3.1	6.7	2.6	-0.5	-0.4	2.3
Weight	0.5	2.3	4.9	0.9	-1.2	-2.2	1.4
Impedance of arm (right)	0.3	1.2	1.8	1.4	-1.1	0.0	1.3
Arm fat percentage (right)	0.6	2.4	5.6	0.5	-0.9	-1.7	2.4
Trunk fat-free mass	0.2	1.3	4.2	0.5	-0.2	-2.0	-0.7
Hip circumference	0.6	2.4	6.4	0.4	-1.3	-2.5	1.2
Time employed in main current job	0.3	0.3	1.0	-0.0	-1.0	0.4	-0.4
Alcohol intake versus 10 years previously	0.9	1.4	3.5	0.3	-1.9	-1.2	-0.8
Father’s age at death	1.9	2.5	8.5	2.9	0.9	-0.6	-0.7
Worrier / anxious feelings	2.4	4.6	12.3	3.5	-0.4	-0.2	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.9	1.4	-1.7	0.5	1.1
Falls in the last year	0.9	1.2	4.2	2.0	-0.2	-0.1	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.1	0.6	0.6	-0.6
Number of live births	0.2	0.3	0.8	0.9	0.5	0.2	-0.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	2.7	1.6	1.5	-1.2	-1.2
Pulse rate	0.9	1.6	3.1	-0.6	-0.7	-1.8	1.6
Happiness	0.2	0.3	0.5	0.6	-0.3	-0.7	0.6
Noisy workplace	1.5	1.8	3.6	1.6	-0.2	-1.9	1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	-1.3	0.3	0.4	-0.9
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	4.8	1.7	2.2	-0.2	0.9
Mouth/teeth dental problems: Dentures	0.6	1.1	3.4	-1.8	-0.3	0.9	0.0
Asthma	0.4	0.7	2.1	-1.5	0.5	-0.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.1	0.2	0.9	0.5	1.1
Medication: Cholesterol lowering	0.8	1.3	2.3	0.7	-1.2	-1.5	-0.9
Depression (self-reported)	0.4	0.5	1.9	-1.4	0.0	-0.2	-0.1
Medication: Lansoprazole	0.7	0.8	1.7	-1.1	-0.1	1.3	-0.3
Prospective memory result	1.1	1.4	3.2	0.8	-1.4	0.0	1.8
Lung cancer (father)	5.5	6.5	17.3	-4.2	1.3	2.4	1.1
Illnesses of mother	0.6	0.8	1.5	1.2	1.2	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	7.1	2.7	0.6	-0.0	-0.7
Pulse wave Arterial Stiffness index	1.3	1.6	2.7	1.3	-0.5	-1.7	1.3
Impedance of arm (left)	0.2	0.7	1.0	0.9	-1.0	0.2	1.0
Arm fat mass (right)	0.6	2.6	5.0	0.6	-1.1	-2.2	1.9
Trunk predicted mass	0.2	1.2	4.1	0.4	-0.3	-2.0	-0.7
Standing height	0.3	2.7	4.8	2.1	-1.0	-2.2	-0.7
Length of working week for main job	2.3	2.5	5.8	2.4	-0.9	0.4	1.8
Exposure to tobacco smoke at home	0.8	0.9	2.5	1.6	-0.2	-0.6	-0.7
Breastfed as a baby	0.3	0.3	0.6	0.7	0.7	0.4	0.3
Tense / ‘highly strung’	0.5	0.9	2.6	1.6	0.4	-0.6	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	1.2	0.9	-0.4	0.2
Hair/balding pattern: Pattern 4	0.2	0.5	0.9	-0.9	-1.0	-0.6	-0.2
Birth weight of first child	0.9	1.7	4.7	1.1	-0.5	-2.2	-0.6
Peak expiratory flow (PEF)	0.6	1.4	3.3	0.3	1.4	-1.8	-0.3
Pulse wave reflection index	0.1	0.1	0.1	0.3	0.3	0.3	0.1
Ever highly irritable/argumentative for 2 days	0.9	1.0	3.9	-0.5	-2.0	0.1	-0.0
Loud music exposure frequency	0.4	0.4	0.9	0.9	-0.5	-0.5	0.5
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	3.0	-1.7	1.2	1.5	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	0.6	0.5	-0.4	0.1
Blood clot in the leg (DVT)	0.4	0.5	1.9	1.4	0.2	0.4	-0.3
Medication: Paracetamol	0.6	1.0	2.2	0.7	-1.5	0.4	1.1
Headache pain in last month	1.6	2.7	4.3	2.1	0.9	-1.2	2.0
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	4.6	-1.0	1.4	2.1	0.1
Glaucoma (self-reported)	1.2	1.4	2.6	-1.6	-1.6	-0.3	-0.6
Gout (self-reported)	0.6	0.8	1.4	0.8	-1.0	-0.6	1.2
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	3.3	0.4	-0.5	1.2	1.8
Medication: Amlodipine	0.5	0.8	1.9	0.9	0.4	-0.5	1.4
Medication: Ventolin 100micrograms inhaler	1.5	1.9	4.4	-2.1	0.1	-0.9	-1.5
Birth weight	2.0	4.4	13.6	1.9	-0.3	-3.7	-0.4
Chronic bronchitis/emphysema (mother)	3.2	3.7	12.3	-3.5	0.7	1.0	-1.0
High blood pressure (siblings)	0.4	0.5	2.0	0.0	0.2	0.2	1.4
Forced vital capacity (FVC), Best measure	0.7	2.4	8.0	2.8	-0.4	-0.3	-1.2
Body fat percentage	0.9	3.4	7.8	1.1	-1.2	-1.8	2.8
Leg fat percentage (right)	0.8	3.0	6.4	1.0	-1.5	-1.4	2.5
Arm fat-free mass (right)	0.2	0.9	3.6	0.1	0.3	-1.9	-0.2
Exposure to tobacco smoke outside home	0.8	1.1	1.6	1.0	1.3	0.2	1.2
Comparative body size at age 10	0.1	0.3	0.8	-0.7	0.1	-0.1	0.9
Number of full brothers	1.3	1.7	2.8	-1.7	0.7	-1.5	-1.0
Worry too long after embarrassment	1.3	2.1	7.3	2.7	-0.0	0.6	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	6.3	2.5	-0.1	-0.4	1.3
Wheeze or whistling in the chest in last year	1.2	2.2	7.7	-2.8	-0.8	0.6	0.1
Number of children fathered	0.2	0.3	0.5	-0.6	-0.4	-0.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.5	-1.6	0.9	0.1	-1.6
Age at first live birth	1.7	3.1	6.6	-0.3	1.3	-2.6	-2.0
Pulse wave peak to peak time	1.3	1.5	2.6	-1.2	0.5	1.6	-1.3
Health satisfaction	0.3	0.4	1.3	-0.4	-0.1	-1.2	0.1
Shortness of breath walking on level ground	1.5	1.8	5.7	1.0	0.4	0.2	2.4
Qualifications: College or University degree	0.5	1.5	3.7	-0.6	-1.3	-0.0	-1.9
Eye problems/disorders: None of the above	1.1	1.3	3.1	1.7	0.3	0.1	1.4
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.2	-0.4	-0.0	-0.2	0.1
Emphysema/chronic bronchitis	0.6	0.6	1.6	-1.3	-0.6	0.6	0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	-0.4	0.7	0.0	0.3
Neck or shoulder pain in last month	3.6	5.2	15.7	1.6	-1.1	-4.0	-1.1
Medication: Blood pressure	0.8	1.4	3.8	0.9	-0.8	-1.9	0.5
Angina (self-reported)	1.0	1.3	4.2	2.1	-0.3	0.8	0.5
Migraine (self-reported)	0.4	0.5	1.1	0.6	-0.2	1.1	0.8
Medication: Ibuprofen	0.3	0.3	0.9	-0.1	1.0	0.1	0.6
Medication: Allopurinol	1.3	1.7	3.8	1.5	-0.2	-0.9	2.0
Medication: Omeprazole	1.8	2.1	3.3	0.1	-1.8	1.4	1.8
Medication: Seretide 50 evohaler	0.6	0.7	1.7	-1.3	-0.2	0.9	0.1
Mean time to correctly identify matches	1.7	3.3	11.0	0.4	-3.3	-0.9	1.1
Heart disease (mother)	0.7	0.9	1.6	1.3	-1.2	-0.4	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.8	3.3	7.4	1.3	1.4	-1.5	2.7
Whole body fat mass	0.7	3.1	5.3	1.2	-1.1	-2.1	2.3
Leg fat mass (right)	0.6	2.4	4.8	0.9	-1.1	-1.7	2.2
Arm predicted mass (right)	0.1	0.7	2.4	0.1	0.5	-1.6	-0.2
Pulse rate, automated reading	0.4	1.2	3.7	-1.9	-0.3	-0.9	0.5
Alcohol intake frequency.	0.7	1.7	3.6	1.2	-1.2	-0.4	1.9
Comparative height size at age 10	0.2	1.2	2.9	0.8	-1.7	-1.1	-0.4
Number of full sisters	0.8	0.9	1.8	0.1	0.8	1.3	1.1
Suffer from ‘nerves’	0.5	0.7	2.2	1.5	0.3	-0.1	0.8
Overall health rating	1.0	2.1	5.4	0.8	-2.3	-0.4	1.4
Chest pain or discomfort	0.5	0.7	2.1	0.7	0.2	-0.2	1.4
Had major operations	0.5	0.6	1.5	1.2	0.1	0.0	1.0
Age at last live birth	1.9	2.8	4.5	-0.8	1.8	-1.7	-2.1
Family relationship satisfaction	0.6	0.7	2.9	-0.1	-0.1	-0.1	1.7
Leg pain on walking	1.7	2.2	5.9	1.3	-0.9	-2.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.0	-1.4	0.3	-0.3	-1.0
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.2	0.1	1.7	0.5	1.8
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	4.8	-2.2	-1.2	-0.4	-1.2
Medication: Aspirin	0.6	0.8	2.1	-0.1	-0.7	-0.6	-1.5
Supplements: Vitamin C	1.4	1.7	3.4	1.8	1.0	-1.1	1.0
Knee pain experienced in last month	2.3	3.6	14.1	3.8	0.5	0.4	0.0
Hypertension (Self-reported)	0.2	0.5	0.8	0.9	-0.3	-0.9	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.6	-0.9	-0.6	0.2	-1.3
Illnesses of father: Heart disease	0.5	0.7	1.5	1.2	-0.2	0.4	-1.0
Illnesses of siblings: Diabetes	1.3	1.6	3.6	-1.9	-1.5	-0.2	-0.8
Smoking status: Previous	1.5	2.2	4.1	2.0	-1.3	-0.7	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.8	0.7	-0.1	-1.3	-0.6
Whole body fat-free mass	0.1	0.8	3.2	0.3	-0.1	-1.8	-0.2
Leg fat-free mass (right)	0.1	0.5	2.1	0.1	-0.0	-1.4	0.2
Arm fat percentage (left)	0.5	2.2	4.9	0.2	-1.0	-1.7	2.2
Average weekly red wine intake	0.0	0.1	0.2	0.1	0.4	-0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	0.9	0.2	0.3	-0.2
Mood swings	0.3	0.6	1.0	1.0	0.0	0.8	0.7
Loneliness, isolation	2.1	3.0	5.8	2.4	-1.3	-0.5	2.0
Long-standing illness, disability or infirmity	1.2	1.9	3.1	1.2	-1.7	-1.8	0.3
Ever had bowel cancer screening	1.2	1.4	4.7	0.6	-0.2	-0.9	-2.2
Diabetes diagnosed by doctor	0.2	0.3	1.3	-1.1	0.1	-0.2	0.0
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	6.3	0.9	0.5	-2.5	-1.3
Friendships satisfaction	0.1	0.2	0.4	-0.3	-0.6	0.4	0.2
Qualifications: nursing, teaching	1.2	1.9	3.1	-0.2	-1.7	1.8	-1.2
Commuting to job workplace: Walk	0.0	0.0	0.1	-0.2	0.3	-0.1	0.1
Eye problems/disorders: Cataract	0.7	0.8	2.7	-0.0	1.6	-0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.2	-1.1	-1.5	-0.2	0.4
Medication for cholesterol	1.1	1.6	3.6	1.7	-0.1	-1.9	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.1	0.6	-0.7	0.4	-1.8
Back pain experienced in last month	1.4	2.1	4.5	1.9	-2.1	0.4	-0.1
Mineral and other dietary supplements	0.4	0.6	2.2	-1.5	0.2	0.0	0.2
Breast cancer (self-reported)	0.1	0.2	0.4	0.5	0.6	-0.1	-0.1
Asthma (self-reported)	0.5	1.0	3.2	-1.8	0.5	-0.6	-0.5
Osteoporosis (self-reported)	1.7	2.1	4.4	2.1	1.1	-0.8	1.5
Osteoarthritis (self-reported)	0.4	0.5	0.9	1.0	-0.7	-0.7	0.1
Medication: Aspirin	0.7	0.9	3.2	-0.2	-0.5	-0.5	-1.8
Medication: Gliclazide	0.6	0.6	1.6	0.6	0.3	0.8	1.2
Illnesses of father: None of the above (group 1)	1.0	1.3	4.0	0.8	-0.6	-0.1	2.0
Smoking status: Current	0.6	0.9	2.3	-0.8	-0.0	1.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.5	13.0	3.6	0.7	0.4	-0.4
Whole body water mass	0.2	0.9	3.5	0.3	0.0	-1.9	-0.2
Leg predicted mass (right)	0.1	0.5	2.1	0.1	0.0	-1.5	0.2
Arm fat mass (left)	0.6	2.4	4.4	0.6	-1.0	-2.1	2.0
Number of self-reported non-cancer illnesses	0.9	1.6	2.6	1.6	-1.0	-1.4	1.1
Average weekly champagne plus white wine intake	1.1	1.5	3.5	1.3	0.8	-0.4	1.9
Miserableness	0.2	0.4	1.0	-0.7	-1.0	0.4	0.0
Guilty feelings	1.4	2.1	6.1	2.5	-1.2	0.8	0.5
Wears glasses or contact lenses	0.7	0.8	2.5	-0.6	0.4	-0.7	-1.6
Ever taken oral contraceptive pill	2.1	2.3	6.6	-0.0	2.6	-1.5	-0.6
Hearing aid user	0.4	0.5	1.0	0.8	-1.0	-0.6	-0.0
Mother’s age at death	1.5	1.9	5.2	1.4	0.6	2.3	0.5
Financial situation satisfaction	0.2	0.2	0.6	0.8	-0.2	0.3	0.4
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.2	0.8	-1.5	-2.3	0.1
Commuting to job workplace: Public transport	0.8	1.0	3.1	-0.5	-1.8	0.8	0.3
Eye problems/disorders: Glaucoma	2.2	2.6	4.0	-1.9	-2.0	0.3	-1.7
Medication: Blood pressure	0.9	1.6	4.2	-2.1	1.0	1.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.0	1.4	0.9	-0.9	-0.4
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.4	1.2	-1.1	-1.0	-0.8
High cholesterol (Self-reported)	0.5	0.9	1.7	-0.2	-1.3	-1.1	-0.6
Medication: Bendroflumethiazide	0.2	0.3	1.1	-1.1	0.2	-0.1	-0.4
Medication: Paracetamol	0.8	1.2	3.3	0.7	-1.8	0.1	1.0
Medication: Lisinopril	0.9	1.1	2.7	0.4	-1.0	-1.6	0.9
Medication: Atorvastatin	0.7	0.9	1.6	0.7	-1.3	1.2	-0.4
Illnesses of father: High blood pressure	0.8	1.0	2.0	0.3	1.4	1.4	0.3
Alcohol drinker status: Never	0.5	0.6	1.3	-0.5	-0.8	1.1	-0.3
Ever smoked	0.5	0.9	2.3	1.5	-0.9	0.4	0.3
Basal metabolic rate	0.2	1.1	4.2	0.4	-0.3	-2.1	0.1
Leg fat percentage (left)	0.8	2.9	6.6	1.0	-1.6	-1.2	2.6
Arm fat-free mass (left)	0.2	1.2	4.6	0.6	0.2	-2.1	0.0
Number of operations (self-reported)	0.4	0.6	1.0	0.8	0.7	1.0	0.3
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.7	0.7	0.4	-0.0
Irritability	0.7	1.1	1.9	1.0	-1.1	0.4	1.4
Risk taking	0.2	0.4	1.1	1.0	0.1	0.5	0.3
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.2	0.6	-0.4	1.1	0.1
Fractured/broken bones in last 5 years	0.3	0.4	1.4	-0.4	1.2	-0.3	-0.4
Age started oral contraceptive pill	1.2	1.5	3.7	1.3	-1.9	-0.6	-0.2
Diastolic blood pressure, automated reading	0.6	1.7	4.2	-0.7	2.1	-0.7	1.3
Ever depressed for a whole week	0.1	0.1	0.1	0.4	-0.4	-0.1	0.1
Unable to work because of sickness or disability	1.0	1.3	2.8	0.9	-1.3	-0.3	1.7
Commuting to job workplace: Cycle	0.2	0.2	0.6	0.4	-0.8	0.1	-0.2
Myopia	0.6	0.9	1.8	0.7	0.6	1.3	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.5	-1.9	0.1	0.8	-1.2
Cholesterol lowering medication	0.2	0.3	1.0	-0.4	0.3	0.3	1.0
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.6	-0.3	-1.6	1.5	1.4
Pain experienced in last month	2.2	3.7	9.9	-3.1	-0.2	2.1	-0.9
Supplements: Calcium	0.9	1.0	2.3	1.0	-0.4	0.6	1.5
Basal cell carcinoma (self-reported)	0.7	0.8	1.5	-0.4	-1.2	-0.2	-1.2
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.0	0.2	-0.5	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.7	1.3	0.3	0.6	0.0
Heart disease (siblings)	0.5	0.6	0.9	0.9	-0.1	1.0	0.8
Alcohol drinker status: Previous	0.3	0.4	0.9	1.0	0.1	-0.6	0.4
Pack years of smoking	10.4	15.2	59.9	-7.7	-0.4	0.5	0.7
Impedance of whole body	0.1	0.5	0.9	0.9	-0.4	0.3	0.9
Leg fat mass (left)	0.6	2.4	4.8	0.8	-1.1	-1.7	2.2
Arm predicted mass (left)	0.2	0.9	3.3	0.5	0.1	-1.8	0.3