Hub : Traits :

Pack years adult smoking proportion

96 significantly associated models · 24 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	48381826	49817450	1	1	4.3e-08	8.0e-06	9.3e-01	100	QRICH1
2	7	73624615	74494207	1	1	2.4e-07	1.3e-07	7.7e-03	74	AC004166.6
3	10	64531160	65911294	2	1	1.2e-08	1.5e-07	4.3e-01	98	JMJD1C-AS1
4	14	103398706	104866687	3	1	6.7e-08	2.1e-07	6.3e-01	99	KLC1
5	15	77859168	79802863	14	8	2.9e-76	7.4e-76	1.0e+00	100	ADAMTS7 CHRNA5 CHRNB4 DNAJA4 PSMA4
6	17	35152143	36441093	2	1	1.9e-07	1.1e-06	4.4e-01	98	DUSP14
7	19	41034912	41537868	1	1	5.6e-09	2.5e-09	5.5e-05	54	RAB4B

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Pack years of smoking	58.55	11	9	20.0	1.00	7.5e-20	AC004166.6 ADAMTS7 CHRNA5 CHRNB4 DNAJA4 DUSP14 JMJD1C-AS1 KLC1 PSMA4 QRICH1 RAB4B
Lung cancer (father)	16.46	4	2	4.4	0.99	9.2e-04	ADAMTS7 CHRNA5 CHRNB4 PSMA4
Chronic bronchitis/emphysema (father)	12.08	3	2	4.4	1.00	1.5e-03	CHRNA5 CHRNB4 PSMA4
Forced expiratory volume in 1-second (FEV1), predicted percentage	10.25	5	3	6.7	-0.94	6.2e-04	ADAMTS7 CHRNA5 CHRNB4 JMJD1C-AS1 PSMA4
Chronic bronchitis/emphysema (mother)	9.42	3	2	4.4	0.98	3.4e-03	CHRNA5 CHRNB4 PSMA4
Father's age at death	8.68	3	2	4.4	-0.99	1.0e-02	CHRNA5 PSMA4 QRICH1
Angina (self-reported)	7.62	3	2	4.4	0.00	1.0e+00	ADAMTS7 CHRNA5 CHRNB4
Angina	7.18	3	1	2.2	0.00	1.0e+00	ADAMTS7 CHRNA5 CHRNB4
Emphysema/chronic bronchitis	5.48	2	0	0.0	0.00	1.0e+00	CHRNA5 PSMA4
Current tobacco smoking	4.88	3	1	2.2	0.00	1.0e+00	KLC1 PSMA4 RAB4B
Schizophrenia (2018)	4.83	3	2	4.4	0.00	1.0e+00	CHRNA5 KLC1 PSMA4
Maternal smoking around birth	4.76	2	0	0.0	0.00	1.0e+00	KLC1 PSMA4
Heart disease (mother)	4.54	1	0	0.0	0.00	1.0e+00	ADAMTS7
Qualifications: CSEs or equivalent	4.51	3	0	0.0	0.00	1.0e+00	CHRNB4 DNAJA4 JMJD1C-AS1
Bipolar Disorder or Schizophrenia	4.37	3	2	4.4	0.00	1.0e+00	CHRNA5 KLC1 PSMA4
Illnesses of father: Heart disease	4.16	2	1	2.2	0.00	1.0e+00	ADAMTS7 CHRNB4
Forced expiratory volume in 1-second (FEV1), Best measure	4.06	3	2	4.4	-0.98	4.2e-03	CHRNA5 PSMA4 QRICH1
Overall health rating	3.91	4	1	2.2	-0.34	6.6e-01	AC004166.6 KLC1 PSMA4 QRICH1
Mother's age at death	3.79	3	0	0.0	0.00	1.0e+00	CHRNA5 KLC1 PSMA4
Smoking status: Current	3.75	3	0	0.0	0.00	1.0e+00	JMJD1C-AS1 KLC1 RAB4B
Risk taking	3.71	3	0	0.0	0.00	1.0e+00	CHRNA5 KLC1 PSMA4
Mouth/teeth dental problems: Dentures	3.70	2	0	0.0	0.00	1.0e+00	CHRNA5 PSMA4
Schizophrenia (2014)	3.56	3	2	4.4	0.00	1.0e+00	CHRNA5 KLC1 PSMA4
Smoking status: Previous	3.43	2	0	0.0	0.00	1.0e+00	CHRNA5 RAB4B
Forced expiratory volume in 1-second (FEV1)	3.42	3	2	4.4	-0.98	2.1e-02	CHRNA5 PSMA4 QRICH1
Qualifications: None of the above	3.41	2	2	4.4	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Coronary Artery Disease (CAD)	3.40	1	1	2.2	0.00	1.0e+00	ADAMTS7
Age when periods started (menarche)	3.37	3	1	2.2	0.00	1.0e+00	AC004166.6 PSMA4 QRICH1
Financial difficulties in last 2 years	3.35	1	0	0.0	0.00	1.0e+00	KLC1
Frequency of tiredness / lethargy in last 2 weeks	3.27	3	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1 QRICH1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.16	1	1	2.2	0.00	1.0e+00	JMJD1C-AS1
Pain experienced in last month	3.10	2	0	0.0	0.00	1.0e+00	CHRNA5 QRICH1
Miserableness	3.07	1	1	2.2	0.00	1.0e+00	QRICH1
Knee pain experienced in last month	3.06	1	0	0.0	0.00	1.0e+00	CHRNA5
Age at first live birth	3.05	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Ever smoked	3.03	2	0	0.0	0.00	1.0e+00	CHRNA5 PSMA4
Qualifications: College or University degree	2.99	3	2	4.4	0.00	1.0e+00	DUSP14 JMJD1C-AS1 QRICH1
Smoking Status	2.94	3	1	2.2	0.00	1.0e+00	CHRNA5 KLC1 QRICH1
Wheeze or whistling in the chest in last year	2.93	2	0	0.0	0.00	1.0e+00	CHRNA5 PSMA4
Ever depressed for a whole week	2.83	1	0	0.0	0.00	1.0e+00	QRICH1
Loneliness, isolation	2.79	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Qualifications: A levels/AS levels or equivalent	2.78	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Frequency of tenseness / restlessness in last 2 weeks	2.74	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Lung FEV1/FVC ratio	2.69	4	2	4.4	-0.84	7.8e-02	CHRNA5 JMJD1C-AS1 PSMA4 RAB4B
Medication: Bendroflumethiazide	2.63	1	0	0.0	0.00	1.0e+00	ADAMTS7
Heel T-Score	2.59	4	2	4.4	-0.11	8.9e-01	AC004166.6 DUSP14 KLC1 QRICH1
Hearing difficulty/problems with background noise	2.57	1	0	0.0	0.00	1.0e+00	KLC1
Medication: Blood pressure	2.55	1	0	0.0	0.00	1.0e+00	ADAMTS7
Pain all over the body in last month	2.50	1	0	0.0	0.00	1.0e+00	QRICH1
Prostate Cancer	2.49	1	0	0.0	0.00	1.0e+00	QRICH1
Impedance of arm (left)	2.49	2	2	4.4	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Depression (Nagel 2018)	2.48	1	1	2.2	0.00	1.0e+00	JMJD1C-AS1
Intelligence (Savage-Jansen 2018)	2.44	3	2	4.4	0.00	1.0e+00	DUSP14 JMJD1C-AS1 QRICH1
Number of self-reported non-cancer illnesses	2.43	2	0	0.0	0.00	1.0e+00	AC004166.6 KLC1
Diastolic blood pressure, automated reading	2.42	3	1	2.2	0.00	1.0e+00	ADAMTS7 KLC1 QRICH1
Forced vital capacity (FVC), Best measure	2.41	3	1	2.2	-0.95	1.4e-02	CHRNA5 PSMA4 QRICH1
Long-standing illness, disability or infirmity	2.40	1	0	0.0	0.00	1.0e+00	KLC1
Depressed Affect (Nagel 2018)	2.37	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Lung FVC	2.37	4	2	4.4	-0.84	3.5e-02	CHRNA5 JMJD1C-AS1 PSMA4 QRICH1
Financial situation satisfaction	2.26	1	0	0.0	0.00	1.0e+00	QRICH1
Number of full brothers	2.23	1	0	0.0	0.00	1.0e+00	QRICH1
Fed-up feelings	2.22	1	1	2.2	0.00	1.0e+00	QRICH1
Impedance of arm (right)	2.22	3	2	4.4	0.00	1.0e+00	JMJD1C-AS1 QRICH1 RAB4B
Age at last live birth	2.20	1	0	0.0	0.00	1.0e+00	QRICH1
Heart disease (siblings)	2.20	1	0	0.0	0.00	1.0e+00	ADAMTS7
Frequency of depressed mood in last 2 weeks	2.19	1	1	2.2	0.00	1.0e+00	JMJD1C-AS1
Medication: Paracetamol	2.19	2	0	0.0	0.00	1.0e+00	KLC1 QRICH1
Ulcerative Colitis (UC)	2.18	1	1	2.2	0.00	1.0e+00	QRICH1
Age at First Birth	2.15	1	0	0.0	0.00	1.0e+00	QRICH1
Mood swings	2.06	2	1	2.2	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Impedance of whole body	2.04	3	2	4.4	0.00	1.0e+00	JMJD1C-AS1 KLC1 QRICH1
Mouth/teeth dental problems	2.01	1	0	0.0	0.00	1.0e+00	KLC1
Qualifications: nursing, teaching	2.01	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Irritable Bowel Disease (IBD)	1.99	1	1	2.2	0.00	1.0e+00	QRICH1
Reaction Time	1.97	1	0	0.0	0.00	1.0e+00	CHRNA5
Irritability	1.96	1	0	0.0	0.00	1.0e+00	QRICH1
Mouth/teeth dental problems: Mouth ulcers	1.95	1	0	0.0	0.00	1.0e+00	CHRNB4
Medication: Paracetamol	1.95	1	0	0.0	0.00	1.0e+00	QRICH1
Medication for pain relief, constipation, heartburn	1.93	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Past tobacco smoking	1.90	2	0	0.0	0.00	1.0e+00	KLC1 RAB4B
Forced vital capacity (FVC)	1.90	3	0	0.0	-0.97	3.3e-02	CHRNA5 PSMA4 QRICH1
Exposure to tobacco smoke outside home	1.90	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Body mass index (BMI)	1.89	3	2	4.4	0.00	1.0e+00	JMJD1C-AS1 KLC1 QRICH1
BMI	1.88	4	2	4.4	0.92	7.7e-02	JMJD1C-AS1 KLC1 QRICH1 RAB4B
Verbal and Numeric Reasoning (VNR)	1.87	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Alcohol intake frequency.	1.77	1	0	0.0	0.00	1.0e+00	AC004166.6
Ever unenthusiastic/disinterested for a whole week	1.76	1	0	0.0	0.00	1.0e+00	QRICH1
Qualifications: O levels/GCSEs or equivalent	1.72	1	0	0.0	0.00	1.0e+00	QRICH1
Heel bone mineral density (BMD) T-score, automated (left)	1.68	1	1	2.2	0.00	1.0e+00	KLC1
Diabetes diagnosed by doctor	1.66	2	0	0.0	0.00	1.0e+00	AC004166.6 KLC1
Type 2 Diabetes (T2D) (2018)	1.65	2	0	0.0	0.00	1.0e+00	AC004166.6 KLC1
Major Depression (MDD)	1.62	1	0	0.0	0.00	1.0e+00	QRICH1
Chest pain or discomfort	1.61	1	0	0.0	0.00	1.0e+00	QRICH1
Triglycerides	1.60	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Neck or shoulder pain in last month	1.56	1	0	0.0	0.00	1.0e+00	QRICH1
Medication: Co-codamol	1.54	1	0	0.0	0.00	1.0e+00	QRICH1
Fluid intelligence score	1.52	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Neuroticism score	1.49	1	0	0.0	0.00	1.0e+00	QRICH1
Waist Hip Ratio (WHR)	1.47	3	1	2.2	0.00	1.0e+00	ADAMTS7 JMJD1C-AS1 QRICH1
Diabetes (self-reported)	1.46	1	0	0.0	0.00	1.0e+00	AC004166.6
Cardiovascular Disease	1.45	1	1	2.2	0.00	1.0e+00	KLC1
Blood Red Count	1.44	5	2	4.4	-0.08	8.8e-01	CHRNA5 DNAJA4 DUSP14 JMJD1C-AS1 KLC1
Medication: Metformin	1.44	1	0	0.0	0.00	1.0e+00	AC004166.6
Crohns Disease (2017)	1.43	1	0	0.0	0.00	1.0e+00	QRICH1
Neuroticism	1.43	1	0	0.0	0.00	1.0e+00	QRICH1
Tense / 'highly strung'	1.43	1	0	0.0	0.00	1.0e+00	QRICH1
Heel bone mineral density (BMD) T-score, automated (right)	1.38	1	0	0.0	0.00	1.0e+00	KLC1
Impedance of leg (left)	1.33	3	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1 QRICH1
Neuroticism (Nagel 2018)	1.30	1	0	0.0	0.00	1.0e+00	QRICH1
Blood White Count	1.29	4	1	2.2	0.45	5.5e-01	DUSP14 JMJD1C-AS1 KLC1 QRICH1
Impedance of leg (right)	1.29	3	1	2.2	0.00	1.0e+00	JMJD1C-AS1 KLC1 QRICH1
Ulcerative Colitis	1.27	1	0	0.0	0.00	1.0e+00	QRICH1
Hypertension (Self-reported)	1.26	2	0	0.0	0.00	1.0e+00	AC004166.6 KLC1
Systolic blood pressure, automated reading	1.24	1	0	0.0	0.00	1.0e+00	QRICH1
High blood pressure	1.21	2	0	0.0	0.00	1.0e+00	AC004166.6 KLC1
Pulse rate, automated reading	1.20	2	1	2.2	0.00	1.0e+00	KLC1 QRICH1
Vascular/heart problems diagnosed by doctor	1.20	1	0	0.0	0.00	1.0e+00	KLC1
Waist circumference	1.18	1	1	2.2	0.00	1.0e+00	KLC1
Arm fat mass (right)	1.18	1	1	2.2	0.00	1.0e+00	KLC1
Leg fat mass (left)	1.18	2	0	0.0	0.00	1.0e+00	KLC1 QRICH1
Leg fat percentage (left)	1.17	2	0	0.0	0.00	1.0e+00	KLC1 QRICH1
Arm fat percentage (right)	1.16	1	1	2.2	0.00	1.0e+00	KLC1
Breast Cancer	1.15	1	0	0.0	0.00	1.0e+00	JMJD1C-AS1
Blood Platelet Count	1.14	3	3	6.7	0.00	1.0e+00	ADAMTS7 DUSP14 JMJD1C-AS1
Number of operations (self-reported)	1.14	1	0	0.0	0.00	1.0e+00	QRICH1
Peak expiratory flow (PEF)	1.13	1	0	0.0	0.00	1.0e+00	PSMA4
Leg fat percentage (right)	1.11	2	0	0.0	0.00	1.0e+00	KLC1 QRICH1
Leg fat mass (right)	1.11	2	0	0.0	0.00	1.0e+00	KLC1 QRICH1
Arm fat mass (left)	1.11	1	1	2.2	0.00	1.0e+00	KLC1
Hypothyroidism (self reported)	1.10	1	0	0.0	0.00	1.0e+00	QRICH1
Hip circumference	1.10	3	0	0.0	0.00	1.0e+00	ADAMTS7 KLC1 QRICH1
Allergy or Eczema	1.07	1	0	0.0	0.00	1.0e+00	PSMA4
Blood Eosinophil Count	1.06	2	1	2.2	0.00	1.0e+00	KLC1 QRICH1
Pulse rate	1.03	1	0	0.0	0.00	1.0e+00	QRICH1
Arm fat percentage (left)	1.01	1	1	2.2	0.00	1.0e+00	KLC1
Comparative height size at age 10	0.94	3	0	0.0	0.00	1.0e+00	DUSP14 KLC1 QRICH1
Whole body fat mass	0.93	1	0	0.0	0.00	1.0e+00	KLC1
Arm fat-free mass (left)	0.85	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Arm predicted mass (left)	0.81	2	0	0.0	0.00	1.0e+00	JMJD1C-AS1 QRICH1
Body fat percentage	0.80	1	0	0.0	0.00	1.0e+00	KLC1
Weight	0.77	1	0	0.0	0.00	1.0e+00	KLC1
Height	0.72	3	2	4.4	0.00	1.0e+00	JMJD1C-AS1 KLC1 QRICH1
Trunk fat mass	0.70	1	0	0.0	0.00	1.0e+00	KLC1
Trunk fat percentage	0.68	1	0	0.0	0.00	1.0e+00	KLC1
Standing height	0.64	2	1	2.2	0.00	1.0e+00	KLC1 QRICH1
Leg fat-free mass (left)	0.54	1	0	0.0	0.00	1.0e+00	KLC1
Sitting height	0.54	1	0	0.0	0.00	1.0e+00	QRICH1
Systolic Blood Pressure	0.50	1	0	0.0	0.00	1.0e+00	QRICH1
Hair Pigment	0.29	3	1	2.2	0.00	1.0e+00	ADAMTS7 JMJD1C-AS1 KLC1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.292	2.4
GTEx	Liver	1	0.139	1.9
GTEx	Brain Caudate basal ganglia	1	0.109	1.7
GTEx	Brain Cortex	2	0.193	1.7
GTEx	Brain Frontal Cortex BA9	1	0.108	1.7
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.7
GTEx	Brain Putamen basal ganglia	2	0.321	1.7
GTEx	Ovary	1	0.110	1.7
GTEx	Adipose Subcutaneous	2	0.057	1.6
GTEx	Adipose Visceral Omentum	1	0.049	1.6
GTEx	Artery Aorta	1	0.034	1.6
GTEx	Artery Tibial	2	0.053	1.6
GTEx	Brain Cerebellar Hemisphere	1	0.067	1.6
GTEx	Brain Cerebellum	1	0.050	1.6
GTEx	Brain Hippocampus	1	0.191	1.6
GTEx	Brain Hypothalamus	1	0.169	1.6
GTEx	Breast Mammary Tissue	1	0.051	1.6
GTEx	Breast Mammary Tissue (Male)	1	0.084	1.6
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.6
GTEx	Cells EBV-transformed lymphocytes	2	0.141	1.6
GTEx	Colon Sigmoid	1	0.068	1.6
GTEx	Colon Transverse	1	0.048	1.6
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.6
GTEx	Heart Left Ventricle	2	0.131	1.6
GTEx	Lung	1	0.035	1.6
GTEx	Muscle Skeletal	1	0.035	1.6
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.6
GTEx	Skin Sun Exposed Lower leg	3	0.082	1.6
GTEx	Spleen	2	0.142	1.6
GTEx	Stomach	0	0.000	1.6
GTEx	Testis	3	0.095	1.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	2	0.181	1.6
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.6
The Cancer Genome Atlas	Prostate Adenocarcinoma	3	0.065	1.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.6
GTEx	Adrenal Gland	1	0.069	1.5
GTEx	Artery Coronary	1	0.085	1.5
GTEx	Cells Transformed fibroblasts	2	0.048	1.5
GTEx	Esophagus Mucosa	2	0.060	1.5
GTEx	Esophagus Muscularis	0	0.000	1.5
GTEx	Heart Atrial Appendage	0	0.000	1.5
GTEx	Nerve Tibial	3	0.069	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Pituitary	1	0.090	1.5
GTEx	Prostate	1	0.120	1.5
GTEx	Thyroid	0	0.000	1.5
GTEx	Vagina	0	0.000	1.5
GTEx	Whole Blood	0	0.000	1.5
METSIM	Adipose	2	0.043	1.5
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.5
YFS	Blood	2	0.043	1.5
CommonMind	Brain Pre-frontal Cortex	4	0.074	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.5
The Cancer Genome Atlas	Breast Invasive Carcinoma	4	0.091	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.046	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	2	0.156	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.197	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
NTR	Blood	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.058	1.4