Hub : Traits :

Pack years adult smoking proportion

96 significantly associated models · 24 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48381826 49817450 1 1 4.3e-08 8.0e-06 9.3e-01 100 QRICH1
2 7 73624615 74494207 1 1 2.4e-07 1.3e-07 7.7e-03 74 AC004166.6
3 10 64531160 65911294 2 1 1.2e-08 1.5e-07 4.3e-01 98 JMJD1C-AS1
4 14 103398706 104866687 3 1 6.7e-08 2.1e-07 6.3e-01 99 KLC1
5 15 77859168 79802863 14 8 2.9e-76 7.4e-76 1.0e+00 100 ADAMTS7 CHRNA5 CHRNB4 DNAJA4 PSMA4
6 17 35152143 36441093 2 1 1.9e-07 1.1e-06 4.4e-01 98 DUSP14
7 19 41034912 41537868 1 1 5.6e-09 2.5e-09 5.5e-05 54 RAB4B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 4.37 3 2 4.4 0.00 1.0e+00 CHRNA5 KLC1 PSMA4
Depressed Affect (Nagel 2018) 2.37 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Depression (Nagel 2018) 2.48 1 1 2.2 0.00 1.0e+00 JMJD1C-AS1
Intelligence (Savage-Jansen 2018) 2.44 3 2 4.4 0.00 1.0e+00 DUSP14 JMJD1C-AS1 QRICH1
Neuroticism (Nagel 2018) 1.30 1 0 0.0 0.00 1.0e+00 QRICH1
Schizophrenia (2018) 4.83 3 2 4.4 0.00 1.0e+00 CHRNA5 KLC1 PSMA4
Crohns Disease (2017) 1.43 1 0 0.0 0.00 1.0e+00 QRICH1
Irritable Bowel Disease (IBD) 1.99 1 1 2.2 0.00 1.0e+00 QRICH1
Ulcerative Colitis (UC) 2.18 1 1 2.2 0.00 1.0e+00 QRICH1
Major Depression (MDD) 1.62 1 0 0.0 0.00 1.0e+00 QRICH1
Reaction Time 1.97 1 0 0.0 0.00 1.0e+00 CHRNA5
Verbal and Numeric Reasoning (VNR) 1.87 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Breast Cancer 1.15 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Prostate Cancer 2.49 1 0 0.0 0.00 1.0e+00 QRICH1
Age at First Birth 2.15 1 0 0.0 0.00 1.0e+00 QRICH1
Coronary Artery Disease (CAD) 3.40 1 1 2.2 0.00 1.0e+00 ADAMTS7
Schizophrenia (2014) 3.56 3 2 4.4 0.00 1.0e+00 CHRNA5 KLC1 PSMA4
Triglycerides 1.60 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Ulcerative Colitis 1.27 1 0 0.0 0.00 1.0e+00 QRICH1
Blood Eosinophil Count 1.06 2 1 2.2 0.00 1.0e+00 KLC1 QRICH1
Blood Platelet Count 1.14 3 3 6.7 0.00 1.0e+00 ADAMTS7 DUSP14 JMJD1C-AS1
Blood Red Count 1.44 5 2 4.4 -0.08 8.8e-01 CHRNA5 DNAJA4 DUSP14 JMJD1C-AS1 KLC1
Blood White Count 1.29 4 1 2.2 0.45 5.5e-01 DUSP14 JMJD1C-AS1 KLC1 QRICH1
Heel T-Score 2.59 4 2 4.4 -0.11 8.9e-01 AC004166.6 DUSP14 KLC1 QRICH1
BMI 1.88 4 2 4.4 0.92 7.7e-02 JMJD1C-AS1 KLC1 QRICH1 RAB4B
Height 0.72 3 2 4.4 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Waist Hip Ratio (WHR) 1.47 3 1 2.2 0.00 1.0e+00 ADAMTS7 JMJD1C-AS1 QRICH1
Systolic Blood Pressure 0.50 1 0 0.0 0.00 1.0e+00 QRICH1
Smoking Status 2.94 3 1 2.2 0.00 1.0e+00 CHRNA5 KLC1 QRICH1
Allergy or Eczema 1.07 1 0 0.0 0.00 1.0e+00 PSMA4
Cardiovascular Disease 1.45 1 1 2.2 0.00 1.0e+00 KLC1
Hypothyroidism (self reported) 1.10 1 0 0.0 0.00 1.0e+00 QRICH1
Type 2 Diabetes (T2D) (2018) 1.65 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Lung FEV1/FVC ratio 2.69 4 2 4.4 -0.84 7.8e-02 CHRNA5 JMJD1C-AS1 PSMA4 RAB4B
Lung FVC 2.37 4 2 4.4 -0.84 3.5e-02 CHRNA5 JMJD1C-AS1 PSMA4 QRICH1
Neuroticism 1.43 1 0 0.0 0.00 1.0e+00 QRICH1
Hair Pigment 0.29 3 1 2.2 0.00 1.0e+00 ADAMTS7 JMJD1C-AS1 KLC1
Frequency of depressed mood in last 2 weeks 2.19 1 1 2.2 0.00 1.0e+00 JMJD1C-AS1
Systolic blood pressure, automated reading 1.24 1 0 0.0 0.00 1.0e+00 QRICH1
Angina 7.18 3 1 2.2 0.00 1.0e+00 ADAMTS7 CHRNA5 CHRNB4
Medication: Co-codamol 1.54 1 0 0.0 0.00 1.0e+00 QRICH1
Medication: Metformin 1.44 1 0 0.0 0.00 1.0e+00 AC004166.6
Impedance of leg (right) 1.29 3 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Leg fat-free mass (left) 0.54 1 0 0.0 0.00 1.0e+00 KLC1
Trunk fat percentage 0.68 1 0 0.0 0.00 1.0e+00 KLC1
Current tobacco smoking 4.88 3 1 2.2 0.00 1.0e+00 KLC1 PSMA4 RAB4B
Maternal smoking around birth 4.76 2 0 0.0 0.00 1.0e+00 KLC1 PSMA4
Fed-up feelings 2.22 1 1 2.2 0.00 1.0e+00 QRICH1
Frequency of unenthusiasm / disinterest in last 2 weeks 3.16 1 1 2.2 0.00 1.0e+00 JMJD1C-AS1
Age when periods started (menarche) 3.37 3 1 2.2 0.00 1.0e+00 AC004166.6 PSMA4 QRICH1
Heel bone mineral density (BMD) T-score, automated (left) 1.68 1 1 2.2 0.00 1.0e+00 KLC1
Qualifications: CSEs or equivalent 4.51 3 0 0.0 0.00 1.0e+00 CHRNB4 DNAJA4 JMJD1C-AS1
High blood pressure 1.21 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Sitting height 0.54 1 0 0.0 0.00 1.0e+00 QRICH1
Chronic bronchitis/emphysema (father) 12.08 3 2 4.4 1.00 1.5e-03 CHRNA5 CHRNB4 PSMA4
Body mass index (BMI) 1.89 3 2 4.4 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Impedance of leg (left) 1.33 3 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Trunk fat mass 0.70 1 0 0.0 0.00 1.0e+00 KLC1
Waist circumference 1.18 1 1 2.2 0.00 1.0e+00 KLC1
Past tobacco smoking 1.90 2 0 0.0 0.00 1.0e+00 KLC1 RAB4B
Frequency of tenseness / restlessness in last 2 weeks 2.74 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Hearing difficulty/problems with background noise 2.57 1 0 0.0 0.00 1.0e+00 KLC1
Forced vital capacity (FVC) 1.90 3 0 0.0 -0.97 3.3e-02 CHRNA5 PSMA4 QRICH1
Heel bone mineral density (BMD) T-score, automated (right) 1.38 1 0 0.0 0.00 1.0e+00 KLC1
Ever unenthusiastic/disinterested for a whole week 1.76 1 0 0.0 0.00 1.0e+00 QRICH1
Qualifications: None of the above 3.41 2 2 4.4 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Financial difficulties in last 2 years 3.35 1 0 0.0 0.00 1.0e+00 KLC1
Mouth/teeth dental problems 2.01 1 0 0.0 0.00 1.0e+00 KLC1
Pain all over the body in last month 2.50 1 0 0.0 0.00 1.0e+00 QRICH1
Diabetes (self-reported) 1.46 1 0 0.0 0.00 1.0e+00 AC004166.6
Fluid intelligence score 1.52 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Neuroticism score 1.49 1 0 0.0 0.00 1.0e+00 QRICH1
Weight 0.77 1 0 0.0 0.00 1.0e+00 KLC1
Impedance of arm (right) 2.22 3 2 4.4 0.00 1.0e+00 JMJD1C-AS1 QRICH1 RAB4B
Arm fat percentage (right) 1.16 1 1 2.2 0.00 1.0e+00 KLC1
Hip circumference 1.10 3 0 0.0 0.00 1.0e+00 ADAMTS7 KLC1 QRICH1
Father's age at death 8.68 3 2 4.4 -0.99 1.0e-02 CHRNA5 PSMA4 QRICH1
Frequency of tiredness / lethargy in last 2 weeks 3.27 3 1 2.2 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Forced expiratory volume in 1-second (FEV1) 3.42 3 2 4.4 -0.98 2.1e-02 CHRNA5 PSMA4 QRICH1
Pulse rate 1.03 1 0 0.0 0.00 1.0e+00 QRICH1
Qualifications: A levels/AS levels or equivalent 2.78 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Mouth/teeth dental problems: Dentures 3.70 2 0 0.0 0.00 1.0e+00 CHRNA5 PSMA4
Lung cancer (father) 16.46 4 2 4.4 0.99 9.2e-04 ADAMTS7 CHRNA5 CHRNB4 PSMA4
Forced expiratory volume in 1-second (FEV1), Best measure 4.06 3 2 4.4 -0.98 4.2e-03 CHRNA5 PSMA4 QRICH1
Impedance of arm (left) 2.49 2 2 4.4 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Arm fat mass (right) 1.18 1 1 2.2 0.00 1.0e+00 KLC1
Standing height 0.64 2 1 2.2 0.00 1.0e+00 KLC1 QRICH1
Tense / 'highly strung' 1.43 1 0 0.0 0.00 1.0e+00 QRICH1
Peak expiratory flow (PEF) 1.13 1 0 0.0 0.00 1.0e+00 PSMA4
Qualifications: O levels/GCSEs or equivalent 1.72 1 0 0.0 0.00 1.0e+00 QRICH1
Medication: Paracetamol 2.19 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Chronic bronchitis/emphysema (mother) 9.42 3 2 4.4 0.98 3.4e-03 CHRNA5 CHRNB4 PSMA4
Forced vital capacity (FVC), Best measure 2.41 3 1 2.2 -0.95 1.4e-02 CHRNA5 PSMA4 QRICH1
Body fat percentage 0.80 1 0 0.0 0.00 1.0e+00 KLC1
Leg fat percentage (right) 1.11 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Exposure to tobacco smoke outside home 1.90 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Number of full brothers 2.23 1 0 0.0 0.00 1.0e+00 QRICH1
Wheeze or whistling in the chest in last year 2.93 2 0 0.0 0.00 1.0e+00 CHRNA5 PSMA4
Age at first live birth 3.05 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Qualifications: College or University degree 2.99 3 2 4.4 0.00 1.0e+00 DUSP14 JMJD1C-AS1 QRICH1
Emphysema/chronic bronchitis 5.48 2 0 0.0 0.00 1.0e+00 CHRNA5 PSMA4
Medication for pain relief, constipation, heartburn 1.93 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Neck or shoulder pain in last month 1.56 1 0 0.0 0.00 1.0e+00 QRICH1
Angina (self-reported) 7.62 3 2 4.4 0.00 1.0e+00 ADAMTS7 CHRNA5 CHRNB4
Heart disease (mother) 4.54 1 0 0.0 0.00 1.0e+00 ADAMTS7
Whole body fat mass 0.93 1 0 0.0 0.00 1.0e+00 KLC1
Leg fat mass (right) 1.11 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Pulse rate, automated reading 1.20 2 1 2.2 0.00 1.0e+00 KLC1 QRICH1
Alcohol intake frequency. 1.77 1 0 0.0 0.00 1.0e+00 AC004166.6
Comparative height size at age 10 0.94 3 0 0.0 0.00 1.0e+00 DUSP14 KLC1 QRICH1
Overall health rating 3.91 4 1 2.2 -0.34 6.6e-01 AC004166.6 KLC1 PSMA4 QRICH1
Chest pain or discomfort 1.61 1 0 0.0 0.00 1.0e+00 QRICH1
Age at last live birth 2.20 1 0 0.0 0.00 1.0e+00 QRICH1
Knee pain experienced in last month 3.06 1 0 0.0 0.00 1.0e+00 CHRNA5
Hypertension (Self-reported) 1.26 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Illnesses of father: Heart disease 4.16 2 1 2.2 0.00 1.0e+00 ADAMTS7 CHRNB4
Smoking status: Previous 3.43 2 0 0.0 0.00 1.0e+00 CHRNA5 RAB4B
Arm fat percentage (left) 1.01 1 1 2.2 0.00 1.0e+00 KLC1
Mood swings 2.06 2 1 2.2 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Loneliness, isolation 2.79 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Long-standing illness, disability or infirmity 2.40 1 0 0.0 0.00 1.0e+00 KLC1
Diabetes diagnosed by doctor 1.66 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Qualifications: nursing, teaching 2.01 1 0 0.0 0.00 1.0e+00 JMJD1C-AS1
Mouth/teeth dental problems: Mouth ulcers 1.95 1 0 0.0 0.00 1.0e+00 CHRNB4
Smoking status: Current 3.75 3 0 0.0 0.00 1.0e+00 JMJD1C-AS1 KLC1 RAB4B
Forced expiratory volume in 1-second (FEV1), predicted percentage 10.25 5 3 6.7 -0.94 6.2e-04 ADAMTS7 CHRNA5 CHRNB4 JMJD1C-AS1 PSMA4
Arm fat mass (left) 1.11 1 1 2.2 0.00 1.0e+00 KLC1
Number of self-reported non-cancer illnesses 2.43 2 0 0.0 0.00 1.0e+00 AC004166.6 KLC1
Miserableness 3.07 1 1 2.2 0.00 1.0e+00 QRICH1
Mother's age at death 3.79 3 0 0.0 0.00 1.0e+00 CHRNA5 KLC1 PSMA4
Financial situation satisfaction 2.26 1 0 0.0 0.00 1.0e+00 QRICH1
Medication: Blood pressure 2.55 1 0 0.0 0.00 1.0e+00 ADAMTS7
Medication: Bendroflumethiazide 2.63 1 0 0.0 0.00 1.0e+00 ADAMTS7
Medication: Paracetamol 1.95 1 0 0.0 0.00 1.0e+00 QRICH1
Ever smoked 3.03 2 0 0.0 0.00 1.0e+00 CHRNA5 PSMA4
Leg fat percentage (left) 1.17 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Arm fat-free mass (left) 0.85 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1
Number of operations (self-reported) 1.14 1 0 0.0 0.00 1.0e+00 QRICH1
Irritability 1.96 1 0 0.0 0.00 1.0e+00 QRICH1
Risk taking 3.71 3 0 0.0 0.00 1.0e+00 CHRNA5 KLC1 PSMA4
Diastolic blood pressure, automated reading 2.42 3 1 2.2 0.00 1.0e+00 ADAMTS7 KLC1 QRICH1
Ever depressed for a whole week 2.83 1 0 0.0 0.00 1.0e+00 QRICH1
Vascular/heart problems diagnosed by doctor 1.20 1 0 0.0 0.00 1.0e+00 KLC1
Pain experienced in last month 3.10 2 0 0.0 0.00 1.0e+00 CHRNA5 QRICH1
Heart disease (siblings) 2.20 1 0 0.0 0.00 1.0e+00 ADAMTS7
Pack years of smoking 58.55 11 9 20.0 1.00 7.5e-20 AC004166.6 ADAMTS7 CHRNA5 CHRNB4 DNAJA4 DUSP14 JMJD1C-AS1 KLC1 PSMA4 QRICH1 RAB4B
Impedance of whole body 2.04 3 2 4.4 0.00 1.0e+00 JMJD1C-AS1 KLC1 QRICH1
Leg fat mass (left) 1.18 2 0 0.0 0.00 1.0e+00 KLC1 QRICH1
Arm predicted mass (left) 0.81 2 0 0.0 0.00 1.0e+00 JMJD1C-AS1 QRICH1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.057 1.6
GTEx Adipose Visceral Omentum 1 0.049 1.6
GTEx Adrenal Gland 1 0.069 1.5
GTEx Artery Aorta 1 0.034 1.6
GTEx Artery Coronary 1 0.085 1.5
GTEx Artery Tibial 2 0.053 1.6
GTEx Brain Caudate basal ganglia 1 0.109 1.7
GTEx Brain Cerebellar Hemisphere 1 0.067 1.6
GTEx Brain Cerebellum 1 0.050 1.6
GTEx Brain Cortex 2 0.193 1.7
GTEx Brain Frontal Cortex BA9 1 0.108 1.7
GTEx Brain Hippocampus 1 0.191 1.6
GTEx Brain Hypothalamus 1 0.169 1.6
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.7
GTEx Brain Putamen basal ganglia 2 0.321 1.7
GTEx Breast Mammary Tissue 1 0.051 1.6
GTEx Breast Mammary Tissue (Male) 1 0.084 1.6
GTEx Breast Mammary Tissue (Female) 1 0.061 1.6
GTEx Cells EBV-transformed lymphocytes 2 0.141 1.6
GTEx Cells Transformed fibroblasts 2 0.048 1.5
GTEx Colon Sigmoid 1 0.068 1.6
GTEx Colon Transverse 1 0.048 1.6
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.6
GTEx Esophagus Mucosa 2 0.060 1.5
GTEx Esophagus Muscularis 0 0.000 1.5
GTEx Heart Atrial Appendage 0 0.000 1.5
GTEx Heart Left Ventricle 2 0.131 1.6
GTEx Liver 1 0.139 1.9
GTEx Lung 1 0.035 1.6
GTEx Muscle Skeletal 1 0.035 1.6
GTEx Nerve Tibial 3 0.069 1.5
GTEx Ovary 1 0.110 1.7
GTEx Pancreas 0 0.000 1.5
GTEx Pituitary 1 0.090 1.5
GTEx Prostate 1 0.120 1.5
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.6
GTEx Skin Sun Exposed Lower leg 3 0.082 1.6
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 2 0.142 1.6
GTEx Stomach 0 0.000 1.6
GTEx Testis 3 0.095 1.6
GTEx Thyroid 0 0.000 1.5
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.5
GTEx Whole Blood 0 0.000 1.5
METSIM Adipose 2 0.043 1.5
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.5
YFS Blood 2 0.043 1.5
CommonMind Brain Pre-frontal Cortex 4 0.074 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 2 0.121 1.5
The Cancer Genome Atlas Breast Invasive Carcinoma 4 0.091 1.5
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 2.4
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.073 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.098 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.6
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.046 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 2 0.181 1.6
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.5
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.5
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 3 0.065 1.6
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.094 1.6
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.5
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 2 0.156 1.5
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.197 1.5