Hub : Genes

DNAJA4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2540	0.0410	2.8e-16	0.194	0.180	0.195	0.203	0.202	4.5e-23	2.2e-21	3.2e-23	3.4e-24	4.8e-24
2	GTEx	Breast Mammary Tissue (Male)	0.2822	0.1087	2.1e-02	0.012	NA	0.036	NA	0.026	1.6e-01	NA	5.2e-02	NA	8.3e-02
3	GTEx	Skin Sun Exposed Lower leg	0.1360	0.0410	3.5e-05	0.023	NA	0.050	NA	-0.001	5.1e-03	NA	5.3e-05	NA	4.5e-01
4	GTEx	Testis	0.2500	0.0670	2.6e-04	0.149	NA	0.110	NA	0.132	4.0e-07	NA	1.4e-05	NA	1.9e-06
5	METSIM	Adipose	0.0760	0.0255	4.7e-05	-0.001	0.027	0.036	0.028	0.019	6.0e-01	5.2e-05	3.5e-06	3.8e-05	6.7e-04
6	YFS	Blood	0.1087	0.0216	0.0e+00	0.062	0.069	0.075	0.075	0.076	2.2e-19	1.0e-21	2.0e-23	2.4e-23	8.9e-24
7	TCGA	Breast Invasive Carcinoma	0.0244	0.0124	1.5e-03	0.010	0.008	0.003	NA	0.007	3.3e-03	5.8e-03	7.8e-02	NA	1.2e-02
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0394	0.0179	1.2e-03	0.027	0.014	0.002	NA	0.007	4.1e-04	8.0e-03	1.7e-01	NA	4.8e-02
9	TCGA	Prostate Adenocarcinoma	0.0635	0.0302	1.3e-04	0.024	0.039	0.049	NA	0.044	1.5e-03	5.8e-05	7.1e-06	NA	1.8e-05
10	TCGA	Stomach Adenocarcinoma	0.0880	0.0410	3.2e-04	0.081	0.051	0.055	NA	0.073	1.9e-06	1.3e-04	7.6e-05	NA	5.7e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.8	1.3	3.4	1.2	0.9	1.8	-0.7	1.7	-0.6	1.7	-0.4	-0.1	0.2
Bipolar Disorder or Schizophrenia	2.5	6.0	19.3	2.5	1.3	4.4	-0.3	2.5	-2.6	3.9	-1.1	-0.2	1.9
Depressed Affect (Nagel 2018)	0.3	0.7	1.8	-0.4	-1.2	0.4	1.0	-1.1	0.4	0.2	0.5	0.9	1.3
Depression (Nagel 2018)	0.3	0.5	2.6	0.0	-0.0	0.5	-0.3	0.2	0.5	0.5	1.6	0.7	0.8
Intelligence (Savage-Jansen 2018)	2.2	6.6	16.3	-4.0	0.6	-2.6	-1.2	1.1	2.7	-3.2	-0.7	-3.1	-3.6
Neuroticism (Nagel 2018)	1.0	2.2	7.1	1.3	-0.2	1.8	0.3	-1.0	-1.3	2.1	1.2	1.3	2.7
Schizophrenia (2018)	2.7	5.6	18.3	2.2	1.1	4.3	0.2	2.1	-2.8	3.6	-1.1	-0.1	2.2
Schizophrenia vs Biploar Disorder	0.3	0.3	1.3	-0.1	-0.4	-0.1	1.2	-0.6	0.4	-0.7	-0.8	0.4	0.1
Worry (Nagel 2018)	2.0	4.2	10.0	2.6	0.1	3.0	0.7	-0.4	-1.9	2.9	0.2	2.1	3.2
Alzheimer’s Disease (in mother)	0.5	0.6	2.6	0.6	0.6	1.6	-1.1	0.5	0.2	-0.5	0.3	0.6	-0.9
Alzheimer’s Disease (in father)	2.1	2.2	7.9	1.0	-1.6	-1.3	2.8	-1.3	-0.3	-1.1	-1.6	1.9	0.3
Alzheimer’s Disease (including proxy)	0.7	0.9	3.3	1.2	-0.6	-0.3	1.2	-1.1	-0.3	-1.1	-0.4	1.8	0.0
Crohns Disease (2017)	0.6	1.2	4.2	-0.5	1.9	1.2	-2.0	0.9	0.9	0.5	-0.1	-0.8	-0.6
Irritable Bowel Disease (IBD)	0.7	1.8	7.7	-0.8	2.8	1.5	-2.1	0.1	1.0	0.7	-0.4	-0.8	-0.5
Ulcerative Colitis (UC)	0.5	1.0	5.0	-0.9	2.2	1.0	-1.3	-0.3	0.6	0.5	-0.3	-0.6	-0.2
Major Depression (MDD)	1.0	1.2	4.9	-0.4	2.2	0.9	-1.4	-0.4	0.0	-0.1	1.4	-1.1	-0.7
Reaction Time	1.0	1.9	5.4	-0.7	-2.0	-0.6	2.3	-0.7	1.2	-1.6	-1.5	1.3	-0.1
Verbal and Numeric Reasoning (VNR)	2.3	5.5	13.1	-3.6	-1.6	-3.3	-0.5	0.1	2.7	-3.4	0.7	-2.1	-2.3
Breast Cancer	0.1	0.3	1.0	-0.3	0.8	-0.4	-0.8	-0.1	0.6	-0.5	1.0	0.1	-0.1
Ovarian Cancer	0.3	0.4	2.0	0.8	-0.6	-0.1	0.6	-0.4	-1.4	0.5	-0.1	0.2	0.0
Prostate Cancer	2.0	2.8	8.1	2.0	1.0	0.9	0.5	-0.7	-2.3	2.8	-0.2	0.6	2.8
Age at First Birth	0.8	1.2	2.6	1.2	1.6	1.6	-1.3	-0.3	-1.1	1.3	-0.4	-0.5	-0.3
Bipolar Disorder (2011)	2.8	2.8	6.5	2.3	0.1	1.8	1.5	-0.6	-1.0	1.6	-1.4	2.5	2.2
Body Mass Index (BMI) (2010)	1.2	1.6	6.2	0.5	0.5	0.0	-0.3	1.0	1.5	-0.6	2.2	2.5	1.1
Coronary Artery Disease (CAD)	0.7	0.8	1.6	-0.7	0.9	-0.5	-0.6	1.2	1.1	0.8	1.3	-0.2	0.9
Crohns Disease (2012)	0.9	1.4	5.9	-0.3	1.0	0.7	-2.4	1.7	0.9	-0.2	1.3	-0.7	-0.8
Mean Putamen Volume	0.9	1.0	3.0	-1.0	1.7	0.6	-1.3	0.9	0.4	0.2	0.6	-1.7	-0.5
Fasting Glucose	0.8	1.0	2.6	0.4	1.6	0.9	-0.9	1.3	-1.2	1.2	0.4	-0.2	0.6
HbA1C	0.5	0.6	2.5	-0.8	0.4	1.2	-0.2	0.2	1.6	0.2	0.7	0.6	0.6
HDL Cholesterol	0.3	0.5	2.1	0.1	0.2	0.1	0.4	0.6	-0.8	0.9	-1.4	-0.4	0.4
LDL Cholesterol	0.2	0.3	0.8	-0.4	0.6	-0.2	-0.4	0.5	-0.1	-0.4	0.2	-0.9	-0.8
Lupus	0.3	0.4	1.5	-0.5	0.7	-0.3	-0.0	-0.8	0.2	-0.0	1.1	-1.2	0.2
Neuroticism (2016)	1.8	2.6	7.1	1.8	-0.8	1.0	0.6	0.4	-2.3	2.5	0.4	1.3	2.7
Primary Biliary Cirrhosis	0.5	0.7	2.4	0.0	1.4	1.5	-0.7	-0.4	-0.1	0.8	-1.3	-0.3	-0.2
Rheumatoid Arthritis	0.3	0.5	1.0	-0.0	-1.0	0.8	0.4	0.1	-0.7	0.9	-0.8	-0.4	0.7
Schizophrenia (2014)	2.4	5.3	11.0	3.3	0.2	3.3	1.1	1.3	-2.9	3.2	-1.5	1.1	2.4
Triglycerides	0.3	0.4	1.3	-1.1	-0.1	0.3	-0.6	-0.4	0.2	-0.3	1.1	-1.1	-0.2
Type 2 Diabetes (T2D) (2012)	1.2	1.3	5.6	0.6	0.6	1.3	0.9	0.2	-1.3	1.6	-2.4	-0.1	0.5
Ulcerative Colitis	0.3	0.4	1.1	-0.6	0.7	1.1	-0.0	0.0	0.7	0.4	-1.0	0.3	0.3
Blood Eosinophil Count	0.2	1.4	5.8	-1.4	-0.2	-1.4	-0.0	-0.5	-0.4	-0.9	-0.6	-2.4	-1.6
Blood Platelet Count	1.3	15.4	65.8	-4.8	-0.7	-2.6	-1.4	-2.2	-1.6	-2.0	-2.0	-8.1	-6.4
Blood Red Count	2.6	25.3	66.4	-0.3	2.1	-0.1	-1.5	4.5	6.2	0.4	7.8	7.8	8.2
Blood White Count	0.2	1.5	5.7	-0.6	-1.0	0.0	0.0	-0.9	-2.1	1.0	-1.0	-2.4	-0.7
Heel T-Score	0.1	0.7	3.3	-0.1	0.1	-0.5	-0.9	1.8	0.0	0.0	1.6	0.0	0.1
BMI	0.2	1.0	4.2	0.5	-0.1	0.5	0.4	1.0	-0.2	0.9	0.5	1.7	2.0
Height	0.2	3.5	16.2	2.6	-0.3	0.1	1.6	-0.4	-4.0	2.0	-2.1	-0.7	0.5
Waist Hip Ratio (WHR)	0.2	0.9	2.5	-1.2	0.9	-1.5	-0.5	0.4	0.7	-0.6	1.6	-0.9	-0.3
Systolic Blood Pressure	0.1	0.3	1.3	-0.0	-0.3	-0.3	0.4	-1.1	0.1	-0.7	-0.4	0.0	-0.7
Smoking Status	0.7	1.7	4.5	-2.1	-2.1	-1.9	-0.0	0.1	1.5	-1.3	0.0	-0.6	-0.5
Allergy or Eczema	0.2	0.5	1.0	0.4	0.3	-1.0	-0.8	-0.4	0.7	-0.9	0.9	0.8	-0.5
Cardiovascular Disease	0.2	0.6	2.1	0.7	0.4	1.4	0.8	-0.7	-0.8	0.6	-1.1	0.4	0.2
Hypothyroidism (self reported)	0.3	0.8	5.4	0.4	-2.3	0.0	0.3	0.0	0.1	-1.2	0.6	0.7	-0.4
Respiratory disease	1.1	2.4	4.8	-2.1	-0.1	0.5	-0.6	-2.2	1.5	-1.9	-1.0	-1.5	-2.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.6	-1.9	0.3	-0.5	-0.1	-0.6	0.9	-1.0	-0.4	-1.6	-1.1
Lung FEV1/FVC ratio	0.4	2.0	8.9	0.1	-1.1	-3.0	1.5	-2.0	0.1	-1.4	-0.3	1.2	-0.6
Lung FVC	0.1	0.6	3.3	0.2	0.4	-1.8	-0.5	-0.7	0.4	-0.7	0.7	0.5	-0.6
Neuroticism	0.9	2.2	6.3	1.3	-0.2	2.1	0.4	-1.6	-0.8	1.9	0.3	1.7	2.5
Chronotype (morning person)	1.3	3.1	9.5	-2.6	3.1	-0.2	-0.6	0.1	2.9	-1.7	0.2	-0.8	-1.3
Hair Pigment	0.0	0.6	1.4	-1.2	1.0	0.1	-1.1	0.3	0.3	0.9	0.3	-1.1	0.2
Tanning	0.0	0.6	2.0	0.2	-1.2	-0.6	0.3	1.4	-0.8	0.3	-0.0	-1.0	-0.3
Hand grip strength (left)	0.6	1.6	5.6	1.4	0.8	2.4	-0.3	0.8	-0.9	1.9	-1.5	0.2	0.4
Number of treatments/medications taken	1.1	1.9	5.0	1.1	0.0	2.0	0.9	-0.2	-0.5	1.4	-1.2	2.2	2.2
Average weekly spirits intake	0.9	1.1	4.1	-1.6	-1.0	-0.9	-0.4	-0.5	-0.3	-0.3	-0.3	-2.0	-1.1
Sensitivity / hurt feelings	0.8	1.3	4.2	1.2	-0.4	0.7	-0.2	0.0	-0.2	0.9	1.5	2.0	2.0
Frequency of depressed mood in last 2 weeks	1.2	1.6	4.3	1.1	-0.6	1.3	-0.7	0.3	0.3	1.3	2.1	1.8	1.8
Hearing difficulty/problems: Yes	0.6	0.9	1.8	0.8	0.3	-1.1	-0.2	-0.9	-1.1	0.8	1.4	0.8	1.2
Relative age of first facial hair	0.7	1.4	4.2	0.4	-0.9	-2.0	1.6	-1.5	0.4	-1.3	-0.7	1.4	0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	3.5	1.0	-1.9	0.6	-0.6	0.7	-0.2	0.3	0.2	0.3	-0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.1	1.3	-1.2	-1.2	0.6	0.3	-1.4	0.6	0.8	0.7	1.3
Ever had hysterectomy (womb removed)	0.7	0.8	2.9	-0.2	0.4	-0.3	-0.8	-0.7	-0.9	-0.2	-0.1	-1.6	-1.7
Systolic blood pressure, automated reading	0.2	0.7	2.8	0.5	-1.1	-1.7	0.7	-0.7	-1.1	-0.2	-0.4	-0.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.7	-0.8	-0.1	0.2	-0.3	-0.5	-0.0	-0.8	0.8	-0.4	-0.5
Angina	0.7	0.9	5.0	-0.6	-0.2	-2.2	-1.1	0.3	-0.1	0.3	1.5	-0.4	0.3
Medication for hormone replacement therapy	0.8	0.9	3.3	1.0	-0.2	0.5	-1.0	1.8	0.0	0.1	1.5	1.1	0.4
Vitamin and mineral supplements	0.6	0.9	3.3	-0.6	-0.1	1.8	-1.0	0.9	1.0	-0.6	1.1	-0.5	-0.5
Supplements: Zinc	1.2	1.3	3.4	1.2	1.8	-0.1	1.1	0.3	-1.3	1.6	-0.5	0.2	1.5
Medication: Co-codamol	1.9	2.2	7.8	1.2	0.4	2.2	-0.2	0.7	-1.7	2.8	-0.5	0.3	1.9
Medication: Metformin	0.4	0.5	1.1	-0.8	-0.9	-0.9	0.5	-0.9	0.7	-1.0	0.5	0.4	0.1
Diabetes (father)	0.9	1.1	4.0	-2.0	0.9	-0.1	-1.0	-0.6	1.0	-0.6	0.3	-1.7	-0.8
Diabetes (mother)	0.2	0.3	0.6	-0.1	0.0	0.0	-0.5	0.7	-0.3	0.8	0.8	-0.1	0.8
Severe depression (siblings)	0.4	0.5	1.8	-0.8	-0.4	-0.7	-0.7	-0.6	1.3	-0.3	0.2	-0.5	-0.7
Pack years adult smoking proportion	7.8	11.9	63.5	0.8	2.4	8.0	-1.4	6.0	2.7	0.4	0.5	1.3	0.8
Impedance of leg (right)	0.2	1.1	2.6	1.3	-0.4	0.8	0.8	-0.6	-1.6	1.6	-0.5	0.4	1.5
Leg fat-free mass (left)	0.1	0.6	1.2	0.8	0.5	0.8	0.7	0.1	-0.6	0.7	-0.8	1.0	1.1
Trunk fat percentage	1.4	5.5	19.0	2.3	0.1	1.1	2.0	0.9	-3.0	3.2	-0.8	2.1	4.4
Hand grip strength (right)	0.6	1.8	5.0	1.6	0.6	1.5	0.5	0.5	-1.5	2.2	-1.9	0.4	1.1
Townsend deprivation index at recruitment	0.7	1.0	2.0	-0.4	0.8	1.3	1.0	-1.1	1.4	-0.2	-1.2	1.2	0.3
Current tobacco smoking	1.1	1.8	5.2	-1.8	-0.1	0.4	-1.6	2.3	1.5	-0.5	0.8	-1.5	-1.0
Average weekly fortified wine intake	0.5	0.6	2.4	-0.6	-0.4	-0.3	0.3	-1.6	0.9	-1.1	-0.2	-0.1	-0.8
Maternal smoking around birth	2.6	3.7	11.0	2.2	0.8	2.6	2.1	1.0	-0.4	1.2	-3.3	2.6	0.7
Fed-up feelings	0.9	1.6	4.4	1.1	-0.4	2.0	0.4	0.2	-0.2	1.3	0.9	1.8	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.3	-0.2	0.5	1.5	-0.9	0.1	0.7	-0.6	1.4	-0.5	-1.0
Relative age voice broke	1.1	1.7	5.1	1.1	-0.2	-2.1	2.3	-0.6	-0.2	-0.8	-0.7	1.9	0.5
Taking other prescription medications	1.0	1.5	3.7	1.4	-1.9	0.1	1.5	0.6	-1.0	0.4	-0.4	1.8	1.5
Age when periods started (menarche)	1.1	2.5	8.9	1.0	0.9	-0.1	0.3	-1.1	-2.9	3.0	-1.1	-1.5	1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.7	1.0	-0.3	-1.9	0.4	-0.5	-1.9	0.9	0.3	-0.5	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	4.2	0.1	-0.3	-0.2	-0.7	1.5	0.5	-0.6	2.0	0.9	0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.4	0.2	-1.1	-1.2	0.9	-1.0	0.6	-1.1	0.0	0.7	-0.5
Qualifications: CSEs or equivalent	2.5	3.3	13.4	-0.1	0.5	2.5	-1.2	3.7	2.5	-0.3	1.0	1.9	0.7
Serious illness, injury or assault to yourself	0.4	0.5	1.2	0.7	-0.9	-0.7	1.1	-0.4	-0.7	0.0	0.5	0.9	0.9
High blood pressure	0.5	1.4	2.9	1.5	-1.1	0.5	1.5	-1.0	-1.7	1.2	-1.0	0.8	1.1
Hayfever, allergic rhinitis or eczema	0.5	1.2	4.2	-0.3	0.7	-2.1	0.3	-1.1	1.1	-1.6	1.1	0.9	-0.1
Multivitamins +/- minerals	1.1	1.4	5.0	0.2	0.0	-2.2	1.1	-1.8	-1.8	0.2	-1.1	-0.4	-0.0
Stomach or abdominal pain in last month	3.8	4.7	12.5	2.9	-0.0	1.5	1.5	-1.0	-2.6	2.9	-0.1	2.4	3.5
Supplements: Glucosamine	0.9	1.1	5.2	-0.8	-0.3	-2.3	-0.2	-0.1	-0.3	-0.8	0.4	-1.7	-1.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.2	-0.1	2.1	1.5	-1.4	2.0	0.2	0.6	1.1	-0.2	0.2
Medication: Atenolol	1.3	1.7	8.1	0.6	-1.6	-2.9	1.3	-0.5	-1.1	-0.9	1.0	0.9	0.4
Medication: Levothyroxine sodium	0.5	0.9	2.6	0.0	-1.6	0.2	0.8	-1.0	0.3	-1.5	-0.0	1.3	-0.1
Sitting height	0.2	1.2	2.5	-1.1	1.0	0.2	-0.3	-1.3	0.2	-0.6	-1.6	-1.5	-1.6
Chronic bronchitis/emphysema (father)	3.2	3.7	17.3	0.7	-1.2	4.2	-2.1	2.8	-1.2	1.0	0.9	-1.4	-1.0
High blood pressure (mother)	1.6	2.2	6.1	-1.3	1.5	1.6	-2.4	0.8	2.5	-0.5	1.7	0.0	-0.5
Body mass index (BMI)	0.4	1.9	6.6	1.0	0.4	1.2	1.2	0.8	-1.4	1.6	-0.7	1.6	2.6
Impedance of leg (left)	0.2	0.8	2.7	1.1	-0.2	0.4	0.4	-0.4	-1.5	1.6	-0.0	-0.1	1.2
Leg predicted mass (left)	0.1	0.5	1.0	0.7	0.5	0.9	0.6	0.1	-0.5	0.7	-0.9	0.9	1.0
Trunk fat mass	1.1	4.8	15.0	2.3	0.2	1.2	1.8	0.6	-3.0	3.1	-1.1	1.8	3.9
Waist circumference	0.5	2.0	7.2	1.1	0.2	0.8	1.2	0.6	-1.9	2.0	-0.5	1.2	2.7
Number of incorrect matches in round	1.5	2.5	4.3	2.1	-0.4	1.9	1.3	-0.2	-1.7	1.9	-1.8	1.0	1.9
Past tobacco smoking	0.4	0.7	4.8	0.8	2.2	0.5	-0.7	0.2	-0.3	0.4	0.6	0.4	0.1
Alcohol usually taken with meals	0.9	1.4	5.7	-0.7	-2.4	-2.2	0.4	-1.5	0.3	-0.3	0.3	-0.4	0.7
Nervous feelings	1.2	2.2	7.1	1.2	1.0	2.7	-0.3	-0.0	-0.9	2.5	0.2	0.7	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.2	0.9	0.2	1.5	-0.9	0.3	0.5	0.2	1.8	1.8	1.0
Hearing difficulty/problems with background noise	1.0	1.6	8.8	1.2	-1.1	-0.7	0.7	-3.0	-0.7	0.5	0.5	1.1	1.1
Hair/balding pattern: Pattern 2	0.3	0.3	1.0	-0.6	1.0	-0.0	-0.2	0.3	0.2	-0.7	-0.3	-0.5	-0.9
Had menopause	0.6	0.8	2.8	0.3	-1.7	-0.4	-0.4	0.4	-1.2	0.7	1.1	-1.0	0.6
Had other major operations	0.4	0.5	1.9	-0.4	-0.9	-0.9	0.7	-1.4	0.7	-0.6	-0.4	-0.1	-0.2
Forced vital capacity (FVC)	0.2	0.6	2.0	1.0	1.4	0.1	-1.1	-1.2	-0.2	0.3	-0.0	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	5.1	-0.3	-0.7	-0.7	-0.7	1.6	0.7	-1.2	2.3	0.3	-0.4
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	5.1	1.1	-0.4	-0.4	2.3	-2.1	-1.3	0.0	-1.2	0.6	0.2
Qualifications: None of the above	1.7	3.7	11.8	2.2	1.4	1.0	0.7	-0.5	-2.6	3.4	0.1	1.1	3.0
Financial difficulties in last 2 years	0.4	0.6	1.7	-0.4	0.8	0.8	-0.4	0.7	1.3	0.7	0.3	0.6	0.9
Mouth/teeth dental problems	0.9	1.4	5.6	-0.7	-1.1	-2.4	-0.3	-1.1	1.0	-1.7	0.1	0.0	-1.2
Heart attack	0.3	0.4	1.1	-0.6	-0.7	0.1	-1.0	-0.2	1.0	-0.4	0.1	0.1	-0.8
Allergy	0.8	1.7	5.9	1.0	-0.6	1.3	0.2	0.6	-2.2	2.4	-1.5	-0.5	0.9
Pain all over the body in last month	1.0	1.1	3.7	1.3	-1.3	0.4	0.5	0.9	-0.1	0.8	0.0	1.9	1.4
Diabetes (self-reported)	0.4	0.6	1.3	-0.9	-1.0	-1.2	1.1	-0.6	0.6	-1.2	-0.4	0.3	-0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.5	-0.6	0.5	-1.6	1.3	-1.4	-0.1	-0.8	-0.5	-0.6	-0.1
Medication: Ramipril	0.1	0.1	0.4	-0.0	-0.4	-0.6	0.3	-0.3	-0.2	-0.7	-0.3	0.0	-0.3
Medication: Simvastatin	0.5	0.8	2.1	0.6	0.2	1.2	1.1	-0.4	-0.3	0.7	-1.4	0.9	1.1
Fluid intelligence score	3.3	6.8	15.6	-4.0	-1.2	-3.2	-0.7	0.1	3.3	-3.9	0.9	-2.1	-2.9
Illnesses of siblings	0.6	0.8	3.5	1.0	1.3	1.9	-0.9	-0.2	-0.8	0.7	0.1	0.3	-0.1
Neuroticism score	1.6	3.4	9.0	2.1	-0.2	2.4	0.7	-1.0	-0.9	2.4	0.3	2.5	3.0
Weight	0.5	2.5	7.0	1.4	0.4	1.5	1.4	0.0	-1.9	2.0	-1.3	1.4	2.6
Impedance of arm (right)	0.3	1.2	3.3	1.3	-0.1	0.5	1.4	-0.6	-1.2	1.5	-0.3	1.0	1.8
Arm fat percentage (right)	1.1	4.3	14.4	1.7	0.4	1.4	2.0	0.6	-2.4	2.8	-1.2	1.9	3.8
Trunk fat-free mass	0.1	0.6	2.9	0.4	0.0	0.4	0.5	-1.2	-0.7	0.4	-1.7	-0.3	-0.1
Hip circumference	0.6	2.5	6.8	0.9	0.3	1.9	1.7	0.1	-1.6	1.9	-1.9	1.3	2.6
Time employed in main current job	0.2	0.2	1.0	0.1	1.0	-0.4	-0.5	0.7	-0.4	0.0	0.4	0.1	-0.4
Alcohol intake versus 10 years previously	0.5	0.8	2.4	-0.7	-0.0	1.1	-0.2	1.4	-0.3	1.5	-1.3	-0.5	0.2
Father’s age at death	1.4	1.9	5.5	1.1	-0.7	-2.1	0.6	-2.3	-2.4	0.7	-0.8	-0.3	0.5
Worrier / anxious feelings	2.2	4.1	9.5	2.8	-0.9	2.1	1.1	-1.1	-2.1	2.0	1.0	2.7	3.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	7.7	0.7	0.1	2.0	0.0	0.6	-1.2	2.2	1.3	0.7	2.8
Falls in the last year	0.7	0.9	3.3	0.6	0.5	0.1	0.6	0.6	-1.4	1.4	0.3	0.3	1.8
Hair/balding pattern: Pattern 3	0.6	0.9	2.4	-0.2	-1.0	-1.6	-0.6	-1.0	0.4	-1.3	0.6	-0.6	-1.4
Number of live births	0.5	0.7	2.9	0.9	-0.8	-1.7	0.2	0.0	-0.4	-0.8	0.5	1.2	-0.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.4	0.9	1.6	-0.2	-0.9	-1.3	-0.4	0.2	-0.0	0.5	-0.5
Pulse rate	1.5	2.5	6.1	0.4	2.1	1.2	2.0	-0.7	0.9	-0.1	-2.5	2.2	1.7
Happiness	1.0	1.2	2.2	1.5	-0.1	0.9	1.1	-1.2	-1.4	0.9	-0.7	1.4	1.1
Noisy workplace	2.3	2.8	7.2	2.2	1.1	-0.0	2.7	-0.7	-1.5	1.3	-1.3	2.2	2.0
Qualifications: A levels/AS levels or equivalent	1.2	2.7	6.5	-1.6	-0.5	-2.6	1.1	-2.1	1.0	-2.6	-0.5	-1.1	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	4.1	0.5	-2.0	-0.2	0.5	-0.4	0.2	0.0	-0.7	1.8	0.6
Mouth/teeth dental problems: Dentures	0.7	1.2	4.9	-0.2	-0.8	2.2	-0.8	1.6	-0.2	1.3	0.5	-0.5	0.7
Asthma	0.3	0.7	2.8	-0.7	0.5	0.5	-0.3	-0.8	1.0	-1.7	0.2	-0.1	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	0.5	0.8	-0.6	0.9	-0.4	-0.1	-0.1	0.1	1.1	1.1
Medication: Cholesterol lowering	0.4	0.6	3.0	0.2	-0.2	0.6	0.2	-0.2	-0.9	0.9	-1.7	-0.8	-0.0
Depression (self-reported)	1.0	1.2	7.6	0.1	0.6	2.8	-1.3	1.0	0.5	0.6	0.7	-0.1	0.2
Medication: Lansoprazole	0.2	0.2	0.5	-0.3	-0.4	-0.6	-0.5	0.7	0.2	-0.5	0.6	0.1	-0.5
Prospective memory result	0.6	0.7	2.2	0.3	0.3	0.4	-0.2	-1.5	-0.1	0.9	0.1	1.3	1.4
Lung cancer (father)	4.6	5.3	19.3	1.3	-0.1	4.4	-2.3	3.4	-0.5	1.5	3.0	0.8	1.8
Illnesses of mother	0.3	0.4	0.9	0.9	-0.6	-0.7	0.8	-0.3	-0.9	0.2	-0.8	0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.7	0.9	1.3	-0.6	-0.9	-1.2	-0.8	0.4	0.9	0.4	0.1
Pulse wave Arterial Stiffness index	1.6	1.9	5.9	2.0	0.5	1.4	1.2	0.4	-0.8	0.9	-1.2	2.4	1.5
Impedance of arm (left)	0.1	0.5	1.8	0.5	-0.2	0.1	1.2	-0.2	-0.6	0.9	-0.2	0.6	1.4
Arm fat mass (right)	0.9	3.7	11.0	1.6	0.2	1.3	1.9	0.2	-2.3	2.6	-1.7	1.7	3.3
Trunk predicted mass	0.1	0.6	2.8	0.4	0.1	0.5	0.5	-1.2	-0.7	0.5	-1.7	-0.3	-0.1
Standing height	0.1	1.3	3.3	1.1	-0.2	0.5	0.7	-1.8	-1.7	1.4	-1.7	-0.5	0.5
Length of working week for main job	1.2	1.3	2.8	1.4	1.1	-0.3	0.6	0.8	-1.4	0.8	1.2	1.2	1.7
Exposure to tobacco smoke at home	0.5	0.5	2.3	0.4	-0.4	-1.5	0.5	-0.8	-0.7	-0.0	-0.7	-0.4	-0.8
Breastfed as a baby	0.7	0.8	4.6	-1.2	-2.1	-1.1	0.2	0.6	0.6	-0.1	0.3	-0.7	0.1
Tense / ‘highly strung’	1.5	2.6	5.9	2.2	0.5	2.2	-0.2	-0.9	-1.1	2.4	0.6	1.8	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.3	-0.9	0.5	0.8	-0.7	-0.1	-0.1	-0.2	0.6	0.2
Hair/balding pattern: Pattern 4	0.3	0.6	2.2	-0.6	-1.5	-0.6	0.7	-1.1	-0.1	-0.6	-1.0	0.2	-0.7
Birth weight of first child	0.3	0.5	2.4	0.7	-1.1	0.0	0.8	-0.6	-0.4	0.3	-1.5	0.3	-0.1
Peak expiratory flow (PEF)	0.3	0.7	1.9	0.7	1.2	1.2	-0.4	-0.6	0.3	-0.1	-0.8	1.4	-0.1
Pulse wave reflection index	0.5	0.7	2.5	0.3	-0.4	-0.2	0.0	1.6	0.7	-1.2	0.3	1.0	-1.0
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.3	0.4	-0.3	0.2	-0.1	-0.6	-0.9	1.1	0.2	-0.2	0.2
Loud music exposure frequency	2.3	2.6	8.7	1.4	2.3	2.0	-0.4	-0.1	-0.6	2.9	0.2	1.0	2.0
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	6.1	-2.5	-0.8	-1.0	0.1	-0.3	1.7	-2.4	0.4	-1.1	-1.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	1.0	0.3	0.2	0.9	-0.2	-1.0	0.4	0.7	0.5	0.6
Blood clot in the leg (DVT)	0.5	0.7	2.1	1.0	1.5	0.7	-0.8	0.9	0.3	0.5	0.9	0.8	0.0
Medication: Paracetamol	0.5	0.8	3.1	0.6	-0.1	0.3	1.3	-0.4	-0.6	0.8	0.1	1.1	1.8
Headache pain in last month	1.9	3.3	10.4	1.8	-0.3	1.0	2.3	-0.1	-1.4	2.0	-1.4	2.3	3.2
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	4.6	-1.1	0.4	-1.0	-1.1	-0.4	1.4	-1.7	2.1	-0.4	-1.0
Glaucoma (self-reported)	0.4	0.5	1.4	-0.9	0.8	-0.1	0.8	-0.5	0.1	-0.5	-0.7	-1.2	-0.6
Gout (self-reported)	0.8	1.1	4.1	1.3	-0.3	1.0	0.4	0.1	-0.3	1.0	-0.7	2.0	1.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	3.8	0.4	-2.0	-0.1	0.5	-0.6	0.3	-1.1	0.9	1.3	0.4
Medication: Amlodipine	0.6	0.9	2.7	1.0	-0.3	0.2	1.3	-1.7	-0.5	0.4	-0.6	1.0	1.1
Medication: Ventolin 100micrograms inhaler	1.5	1.9	7.6	-0.9	1.0	2.8	-1.8	1.8	0.5	0.2	0.1	-1.4	-1.1
Birth weight	1.8	3.9	10.5	2.4	0.2	0.8	1.8	-2.2	-2.6	2.2	-3.2	1.2	1.0
Chronic bronchitis/emphysema (mother)	1.5	1.7	5.8	-0.8	-0.7	1.1	-0.5	0.7	1.6	-2.4	0.0	-0.3	-2.4
High blood pressure (siblings)	1.2	1.7	5.3	-0.3	-1.2	-2.3	1.6	0.3	1.4	-1.8	-0.4	1.6	0.3
Forced vital capacity (FVC), Best measure	0.2	0.7	1.9	0.9	1.1	-0.1	-1.4	-0.9	-0.8	0.6	1.0	-0.0	-0.1
Body fat percentage	1.4	5.5	18.6	2.2	0.2	1.4	2.1	0.9	-3.0	3.2	-1.1	2.0	4.3
Leg fat percentage (right)	1.4	5.2	16.3	2.4	0.2	1.9	1.7	0.6	-2.9	3.1	-0.9	2.0	4.0
Arm fat-free mass (right)	0.1	0.5	1.7	0.7	0.5	0.7	0.4	-0.3	-1.0	0.7	-1.3	0.0	0.4
Exposure to tobacco smoke outside home	0.7	0.9	2.0	0.5	0.7	-0.9	1.4	1.1	-1.0	1.1	0.1	0.6	1.3
Comparative body size at age 10	0.3	0.8	2.5	1.0	-0.3	1.0	0.7	1.6	-0.3	-0.0	0.1	1.4	0.7
Number of full brothers	0.7	0.8	4.2	-0.3	0.3	2.0	0.2	0.9	0.7	0.5	-1.5	-0.5	-0.2
Worry too long after embarrassment	1.0	1.7	3.3	1.6	-0.1	1.6	-0.4	-1.1	-0.9	1.4	1.6	1.6	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	2.9	1.7	-1.6	0.8	1.1	-1.4	-1.0	0.9	-0.5	1.7	1.6
Wheeze or whistling in the chest in last year	0.6	1.0	3.1	-0.7	0.1	1.8	-1.0	1.4	1.6	-0.5	0.6	0.1	-0.4
Number of children fathered	0.3	0.4	1.5	0.5	-0.0	0.4	-1.2	-0.8	-0.5	0.2	0.6	-0.5	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	3.5	-0.8	1.0	0.2	-1.6	-0.1	0.7	-1.1	0.7	-1.1	-1.9
Age at first live birth	1.0	1.8	10.2	-0.1	-0.1	0.5	1.6	-1.0	-0.3	-0.5	-3.2	-1.1	-1.5
Pulse wave peak to peak time	1.6	1.9	6.3	-2.0	-0.4	-1.3	-1.4	-0.5	0.7	-0.8	1.3	-2.5	-1.4
Health satisfaction	0.9	1.1	3.8	0.7	0.2	1.9	1.4	-1.3	-0.8	0.0	-1.5	0.6	0.4
Shortness of breath walking on level ground	1.8	2.2	6.0	2.4	-0.8	1.4	0.8	-0.1	-0.9	1.6	0.2	2.3	2.1
Qualifications: College or University degree	0.4	1.4	3.7	-1.0	-0.1	-0.3	-0.9	-1.7	0.9	-1.7	0.5	-1.1	-1.9
Eye problems/disorders: None of the above	1.2	1.4	5.8	-0.2	-0.0	-2.4	2.2	-0.0	0.6	-0.5	-0.6	1.1	0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.9	0.3	1.4	0.6	0.3	1.3	0.3	-0.1	0.0	0.3	0.1
Emphysema/chronic bronchitis	1.1	1.3	4.4	-0.4	-0.2	1.1	-0.3	2.1	2.1	-1.1	0.8	0.5	-0.4
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	0.1	0.5	0.4	-0.4	0.0	0.5	-0.5	0.5	0.1	-0.2
Neck or shoulder pain in last month	3.9	5.5	16.1	2.8	1.4	2.1	1.4	-0.5	-4.0	3.5	-2.7	0.3	1.6
Medication: Blood pressure	0.9	1.5	3.6	1.1	-0.1	1.0	1.2	0.6	-1.5	1.9	-1.7	0.5	1.5
Angina (self-reported)	0.7	0.9	5.9	-0.3	-0.4	-2.4	-0.6	0.2	-0.2	0.3	1.4	0.1	0.6
Migraine (self-reported)	0.3	0.4	1.6	0.9	-0.8	-0.2	0.1	0.5	-0.5	-0.1	1.3	0.6	0.4
Medication: Ibuprofen	0.3	0.4	1.2	0.1	1.0	-0.5	1.1	-0.5	0.1	-0.3	-0.4	0.8	0.7
Medication: Allopurinol	1.3	1.8	7.4	1.5	1.1	0.6	1.3	0.3	-0.5	0.7	-0.6	2.7	1.9
Medication: Omeprazole	1.3	1.6	7.1	-1.0	-0.1	0.3	-0.6	0.4	2.7	-1.2	1.7	1.6	0.5
Medication: Seretide 50 evohaler	1.6	1.8	7.0	-1.7	-0.5	0.1	-1.3	1.3	2.6	-1.6	1.2	0.1	-0.9
Mean time to correctly identify matches	1.4	2.7	8.4	0.0	-2.9	-1.8	2.8	-0.9	0.2	-1.6	-1.6	1.3	-0.0
Heart disease (mother)	1.2	1.4	4.8	-2.1	-0.5	-2.2	0.7	-1.4	0.9	-0.2	-1.0	-0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	10.3	2.2	-1.6	-0.7	3.2	-0.7	-1.3	1.2	-1.9	3.1	2.7
Whole body fat mass	1.1	4.5	14.2	2.1	0.1	1.3	1.9	0.6	-2.7	2.9	-1.3	1.9	3.8
Leg fat mass (right)	1.1	4.1	12.2	2.3	0.1	1.4	1.5	0.6	-2.6	2.6	-0.9	2.0	3.5
Arm predicted mass (right)	0.1	0.3	1.1	0.7	0.3	0.6	0.2	-0.2	-1.0	0.5	-0.8	0.0	0.3
Pulse rate, automated reading	0.6	2.0	6.1	-1.2	2.5	2.4	0.3	-0.6	1.8	0.0	-1.0	0.8	1.2
Alcohol intake frequency.	1.0	2.4	7.4	0.8	-1.7	1.7	0.3	2.7	0.1	1.6	0.1	1.4	2.3
Comparative height size at age 10	0.2	1.2	3.2	1.1	0.6	1.8	-1.0	-0.1	-1.7	1.6	-0.1	-0.4	0.8
Number of full sisters	0.6	0.7	2.0	0.2	-0.3	-0.9	0.1	-1.1	1.2	-0.8	0.7	1.4	-0.2
Suffer from ‘nerves’	0.6	1.0	2.1	1.3	-0.0	1.5	0.3	1.1	-0.6	1.0	0.1	1.4	1.2
Overall health rating	1.2	2.6	9.9	1.8	-0.9	3.1	0.3	0.1	-0.8	1.8	0.4	1.9	2.2
Chest pain or discomfort	0.4	0.5	1.8	-0.0	-1.1	0.2	0.6	-0.1	0.1	0.2	0.5	1.3	1.3
Had major operations	0.9	1.0	3.9	1.1	0.2	0.1	0.1	0.7	-0.5	2.0	-0.0	0.9	1.9
Age at last live birth	1.4	2.0	8.7	-0.9	1.3	0.1	1.3	-0.1	0.6	-1.1	-3.0	-0.9	-2.2
Family relationship satisfaction	0.7	0.8	3.0	0.6	0.4	1.0	0.7	0.4	-0.1	0.8	-0.1	1.5	1.7
Leg pain on walking	2.9	3.7	10.9	2.6	1.8	1.9	1.2	-0.5	-3.3	2.4	-1.1	0.8	1.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	1.0	0.2	-0.1	0.6	-0.1	-0.4	0.1	-0.3	-0.3	-0.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.5	1.1	-0.1	-0.6	1.6	0.0	-0.3	-0.4	0.6	1.4	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.2	0.5	1.5	0.1	-0.5	-0.3	-1.1	0.5	-0.1	-0.9	-0.6
Medication: Aspirin	1.2	1.6	6.0	-2.2	-0.4	-1.5	0.1	-0.4	-0.1	0.1	-1.4	-2.4	-0.8
Supplements: Vitamin C	0.8	1.0	3.1	-0.1	0.3	-0.4	1.7	-0.4	0.2	1.0	-1.8	0.7	1.4
Knee pain experienced in last month	2.3	3.6	14.8	3.9	-0.1	-0.4	-0.5	-0.2	-2.7	1.7	2.0	2.2	1.2
Hypertension (Self-reported)	0.4	1.2	2.6	1.3	-1.1	0.9	1.2	-0.9	-1.6	1.3	-0.8	0.5	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	2.8	-1.3	0.2	0.3	-0.5	1.7	1.0	-0.9	0.4	-0.4	-0.8
Illnesses of father: Heart disease	1.0	1.5	4.3	-0.8	1.5	-2.1	-0.9	-0.9	-0.4	-0.1	0.9	-2.0	-1.0
Illnesses of siblings: Diabetes	1.6	1.9	8.8	-3.0	0.5	-1.0	0.5	-0.7	1.4	-1.1	-0.9	-2.1	-0.7
Smoking status: Previous	0.7	1.1	2.7	0.5	-1.2	-0.9	1.5	-1.7	-0.9	0.5	-0.8	0.7	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.2	0.6	1.5	0.2	0.8	-0.6	-1.2	1.0	-1.3	-0.2	0.7
Whole body fat-free mass	0.1	0.4	1.6	0.5	0.4	0.6	0.5	-0.4	-0.8	0.6	-1.2	0.1	0.4
Leg fat-free mass (right)	0.0	0.2	0.5	0.4	0.6	0.5	0.3	0.1	-0.3	0.5	-0.6	0.5	0.7
Arm fat percentage (left)	0.9	3.6	12.2	1.5	0.4	1.4	1.9	0.7	-2.1	2.6	-1.2	1.8	3.5
Average weekly red wine intake	0.7	1.0	2.6	-1.5	-0.5	-1.6	-1.3	0.0	0.9	-0.5	0.3	-1.3	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.2	0.1	-0.2	0.4	-1.1	-0.8	-0.7	1.1	0.3	-0.5	0.3
Mood swings	0.5	1.0	2.0	0.8	-0.9	1.2	-0.4	-0.6	-0.9	1.4	1.1	0.9	1.3
Loneliness, isolation	1.9	2.7	6.9	2.2	0.6	1.3	1.5	-1.3	-0.5	1.6	-0.3	2.6	2.5
Long-standing illness, disability or infirmity	0.8	1.3	4.6	1.1	-1.2	2.1	0.8	-0.4	-0.5	1.1	-0.6	1.3	1.2
Ever had bowel cancer screening	1.2	1.4	3.5	-0.5	-1.1	-1.6	0.7	-0.7	-0.8	-1.0	-0.8	-1.9	-1.8
Diabetes diagnosed by doctor	0.4	0.7	1.4	-1.2	-0.6	-0.6	0.9	-0.7	0.5	-1.1	-1.0	-0.5	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	9.1	-0.7	0.8	-0.2	1.6	-1.5	0.8	-1.3	-3.0	-0.0	-1.4
Friendships satisfaction	0.2	0.2	0.9	0.2	-0.9	-0.0	0.0	-0.7	-0.4	-0.6	0.3	0.5	-0.1
Qualifications: nursing, teaching	2.0	3.1	9.7	-3.1	0.7	-1.9	-1.1	-0.4	1.4	-1.4	0.7	-3.0	-1.6
Commuting to job workplace: Walk	0.5	0.5	1.9	-0.3	1.4	1.1	-0.2	-0.0	1.0	-0.6	0.3	0.1	-0.1
Eye problems/disorders: Cataract	0.6	0.6	2.2	0.8	-0.6	0.5	-0.6	-1.3	0.6	-0.5	-0.5	1.5	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.1	0.4	1.7	1.8	0.6	0.3	-0.4	0.3	-0.1	0.4	0.6
Medication for cholesterol	1.1	1.7	8.2	0.1	-0.1	-1.5	2.3	-0.6	-0.5	0.8	-2.9	-0.0	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	5.1	0.1	0.9	-0.3	-2.3	0.9	-0.2	-0.1	0.9	-0.8	-1.7
Back pain experienced in last month	0.4	0.5	1.3	0.4	-0.4	0.0	-0.4	-0.6	-1.2	0.9	1.0	-0.0	1.0
Mineral and other dietary supplements	0.2	0.3	2.0	-0.3	-0.3	1.4	0.5	0.1	0.1	0.1	-0.6	0.2	0.4
Breast cancer (self-reported)	0.2	0.2	0.8	0.1	-0.8	-0.6	-0.2	-0.9	0.2	-0.1	0.0	0.6	0.0
Asthma (self-reported)	0.5	1.1	3.8	-1.2	0.5	0.3	-0.5	-0.9	1.3	-2.0	0.2	-0.4	-1.3
Osteoporosis (self-reported)	1.6	2.0	7.1	2.7	-1.0	0.3	0.9	0.1	-1.4	1.0	-0.1	2.2	1.8
Osteoarthritis (self-reported)	0.7	0.9	2.3	1.2	-1.1	0.5	0.1	0.6	-1.3	1.5	-0.0	0.2	1.2
Medication: Aspirin	1.2	1.6	5.2	-1.9	-0.3	-1.8	-0.1	-0.5	0.1	-0.4	-1.1	-2.3	-1.6
Medication: Gliclazide	0.6	0.6	2.9	-0.2	-0.3	0.4	-0.5	-0.1	1.7	-0.7	0.9	1.2	0.1
Illnesses of father: None of the above (group 1)	1.4	1.7	7.7	0.7	-1.7	-0.5	1.5	-0.7	1.0	-1.2	-0.6	2.8	0.6
Smoking status: Current	0.9	1.5	3.7	-1.9	-0.5	-0.8	-1.2	1.3	1.4	-0.9	0.5	-1.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	6.1	0.3	-0.0	-2.5	-1.3	-1.3	-0.2	-0.2	1.8	0.5	-0.3
Whole body water mass	0.1	0.4	1.8	0.5	0.4	0.6	0.6	-0.5	-0.7	0.6	-1.4	0.2	0.5
Leg predicted mass (right)	0.0	0.2	0.4	0.3	0.6	0.5	0.3	0.1	-0.2	0.4	-0.6	0.5	0.6
Arm fat mass (left)	0.8	3.3	10.5	1.5	0.1	1.2	1.9	0.3	-2.0	2.4	-1.6	1.7	3.2
Number of self-reported non-cancer illnesses	1.1	1.9	5.1	1.9	-1.5	1.8	1.0	-0.9	-0.4	0.9	-0.4	2.3	1.3
Average weekly champagne plus white wine intake	1.3	1.7	3.6	1.5	-0.9	-1.2	1.1	-1.9	-1.0	0.6	-0.2	1.9	1.7
Miserableness	0.4	0.8	2.4	-1.4	-1.5	1.5	0.2	-0.0	0.9	-0.2	-0.1	-0.2	-0.0
Guilty feelings	0.7	1.0	3.4	0.2	0.4	0.9	-0.6	-0.6	-0.7	1.8	0.9	-0.4	1.8
Wears glasses or contact lenses	0.5	0.5	1.9	0.3	-0.4	0.6	-0.3	0.1	-1.4	0.8	-0.4	-1.4	-0.4
Ever taken oral contraceptive pill	1.7	1.9	3.6	-1.4	-1.7	-0.8	0.6	-1.3	1.1	-1.9	-1.7	-0.5	-1.9
Hearing aid user	1.0	1.1	7.5	-0.3	-2.7	-1.2	0.3	-0.6	-0.1	-0.6	-0.8	-0.3	-0.6
Mother’s age at death	1.3	1.6	5.8	-1.0	-0.8	-2.1	-0.9	-0.3	0.8	-1.6	2.4	-0.3	-0.3
Financial situation satisfaction	0.2	0.2	0.8	0.3	0.6	-0.5	-0.2	-0.2	0.2	0.0	0.9	0.4	0.2
Tinnitus: Yes, now most or all of the time	1.8	2.1	4.9	1.4	0.7	1.6	1.8	-1.1	-1.5	1.7	-2.2	0.6	1.3
Commuting to job workplace: Public transport	0.8	0.9	3.2	-0.8	-0.9	-1.4	0.3	0.3	1.3	-1.8	0.0	0.4	-0.6
Eye problems/disorders: Glaucoma	0.8	1.0	4.8	-0.8	1.4	0.4	-0.6	0.3	-0.8	-0.0	0.3	-2.2	-1.1
Medication: Blood pressure	0.3	0.7	1.8	-0.2	-1.1	0.8	-0.3	-0.9	0.2	-1.3	1.2	-0.3	-0.5
Pain type(s) experienced in last month: Hip pain	0.8	1.0	3.1	1.3	1.2	0.7	-0.6	-1.8	-0.3	1.0	0.3	0.9	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	0.2	0.0	-1.4	0.3	-1.1	-0.6	0.5	-0.9	-0.7	-0.5
High cholesterol (Self-reported)	0.4	0.6	1.6	0.7	1.3	1.1	0.1	-0.3	-0.9	1.0	-1.0	0.1	0.4
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.3	-0.4	1.1	-0.3	-0.1	-0.4	-0.4	-0.3	-0.4	-0.9
Medication: Paracetamol	0.6	1.0	4.4	0.6	-0.0	0.4	1.2	-0.5	-0.9	1.4	-0.3	0.8	2.1
Medication: Lisinopril	2.7	3.5	8.1	2.4	-1.1	2.1	0.5	0.1	-2.8	2.9	-0.5	1.2	2.3
Medication: Atorvastatin	0.6	0.7	1.6	-0.8	-0.4	-1.2	-1.3	-0.9	0.3	-0.2	1.1	-0.9	-0.3
Illnesses of father: High blood pressure	0.6	0.7	2.0	-0.6	-0.4	-1.4	-0.3	1.1	1.0	-1.0	1.1	0.2	-0.2
Alcohol drinker status: Never	0.9	1.1	3.0	-1.0	0.8	0.2	-1.7	1.0	0.3	-0.3	1.7	-1.4	-0.5
Ever smoked	0.8	1.4	7.0	-1.3	-2.7	-1.8	0.2	-0.8	0.2	-0.3	-0.2	-1.0	-0.4
Basal metabolic rate	0.1	0.7	2.1	0.7	0.5	0.9	0.8	-0.5	-1.0	1.0	-1.4	0.4	1.0
Leg fat percentage (left)	1.4	4.9	16.7	2.3	0.3	1.6	1.4	0.8	-2.9	3.2	-0.5	1.8	4.1
Arm fat-free mass (left)	0.2	0.8	2.6	0.8	0.5	0.7	0.8	-0.7	-1.1	1.0	-1.6	0.3	0.8
Number of operations (self-reported)	0.4	0.7	2.5	-0.5	-0.8	-1.6	-0.4	-0.1	1.3	-0.8	0.6	0.3	-0.5
Average weekly beer plus cider intake	0.2	0.3	1.1	0.4	1.1	0.2	0.4	0.3	-0.1	-0.9	0.1	0.8	-0.5
Irritability	0.3	0.5	1.4	0.8	-0.0	0.0	-0.1	-1.0	-0.3	1.2	0.7	0.9	1.1
Risk taking	0.5	0.7	3.5	-0.3	0.8	-1.9	-0.1	-0.8	-0.5	0.8	0.6	-0.4	0.7
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.9	-0.5	-0.4	0.3	-0.9	0.8	0.5	0.4	1.0	-0.3	0.1
Fractured/broken bones in last 5 years	0.5	0.6	1.7	-1.3	-0.1	-1.1	-0.4	0.8	1.3	-0.6	-0.1	-0.7	-0.5
Age started oral contraceptive pill	0.5	0.7	1.9	1.2	-0.8	-0.9	0.6	-1.1	-1.4	-0.4	-0.3	0.2	-0.3
Diastolic blood pressure, automated reading	0.3	0.9	2.2	-0.1	-1.2	0.5	0.8	0.6	1.1	-1.4	-0.8	1.5	-0.3
Ever depressed for a whole week	0.7	0.9	2.9	0.9	-1.2	0.5	1.1	-1.7	-1.3	-0.2	-0.4	0.3	-0.0
Unable to work because of sickness or disability	1.3	1.7	5.9	1.4	0.7	0.5	1.5	0.8	0.1	1.1	-0.3	2.4	2.0
Commuting to job workplace: Cycle	0.5	0.6	2.5	1.6	-0.7	0.2	0.7	-0.4	-1.1	-0.2	-0.2	1.0	-0.5
Myopia	0.9	1.3	5.1	-1.4	-1.9	-2.3	-0.0	0.6	1.0	-0.7	0.8	0.0	0.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.0	-1.4	1.7	-0.0	-1.7	0.8	1.4	-1.1	1.0	-1.2	-1.2
Cholesterol lowering medication	0.5	0.7	2.4	0.5	1.1	0.7	-0.4	-0.5	0.5	-0.5	1.3	1.6	0.5
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	5.5	-0.7	-0.1	1.2	-1.2	0.9	2.2	-1.1	2.4	1.5	0.3
Pain experienced in last month	2.9	4.9	12.6	-3.5	-0.6	-0.6	-2.1	0.7	3.2	-2.4	1.0	-2.5	-2.8
Supplements: Calcium	1.0	1.2	4.2	-0.9	0.9	-1.5	0.7	-0.0	2.0	-1.3	0.5	1.1	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.2	0.8	1.1	1.0	-0.7	-0.6	-0.9	0.7	0.5	-0.6	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.5	1.1	-0.7	-1.1	-0.2	-0.7	-0.6	1.1	-0.5	0.0	0.0	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.9	0.9	1.4	0.8	-0.8	1.0	0.3	0.8	1.2	0.6	0.3
Heart disease (siblings)	0.4	0.5	1.4	-1.0	-0.6	-1.0	-0.5	-0.5	0.7	-0.4	1.2	-0.6	0.2
Alcohol drinker status: Previous	0.6	0.7	1.3	1.1	-0.0	-0.3	0.9	1.2	-0.8	0.9	-0.7	0.7	0.9
Pack years of smoking	7.0	10.4	53.6	1.2	2.0	7.3	-1.0	5.9	2.1	0.7	0.3	1.6	1.2
Impedance of whole body	0.1	0.7	1.9	0.9	0.1	0.3	0.7	-0.1	-1.1	1.3	0.0	0.3	1.4
Leg fat mass (left)	1.0	3.9	12.0	2.2	0.1	1.3	1.5	0.7	-2.6	2.6	-0.8	1.9	3.5
Arm predicted mass (left)	0.1	0.7	1.6	0.8	0.3	1.0	0.7	-0.5	-1.0	1.0	-1.3	0.5	1.0