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chr22:37,781,874-41,004,384

Best TWAS P=3.15e-09 · Best GWAS P=1.67e-09 conditioned to 0.0241

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	TMEM184B	0.08	0.08	lasso	4	0.07	1.0e-06	4.7	-5.5	4.3e-08	-0.66	0.65	0.32	FALSE
2	GTEx	Artery Aorta	PLA2G6	0.10	0.02	enet	9	0.02	4.5e-02	4.7	5.9	3.2e-09	0.70	0.07	0.63	TRUE
3	GTEx	Artery Aorta	AL021977.1	0.13	0.00	enet	17	0.01	8.7e-02	5.0	-5.4	8.6e-08	-0.58	0.05	0.58	FALSE
4	GTEx	Brain Cortex	TMEM184B	0.29	0.12	lasso	7	0.09	1.6e-03	5.2	-5.3	9.2e-08	-0.72	0.02	0.80	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	PLA2G6	0.28	0.17	enet	13	0.18	1.3e-06	-4.3	5.3	1.1e-07	0.73	0.13	0.80	FALSE
6	GTEx	Cells Transformed fibroblasts	PLA2G6	0.23	0.09	lasso	9	0.10	9.9e-08	5.4	5.6	1.8e-08	0.86	0.17	0.83	FALSE
7	GTEx	Esophagus Mucosa	PLA2G6	0.22	0.02	lasso	6	0.04	1.9e-03	5.4	5.6	2.0e-08	0.87	0.06	0.93	FALSE
8	GTEx	Esophagus Muscularis	TMEM184B	0.11	0.01	enet	10	0.06	2.7e-04	2.9	-5.3	1.1e-07	-0.69	0.17	0.48	FALSE
9	GTEx	Muscle Skeletal	DMC1	0.13	0.01	enet	17	0.04	3.3e-05	4.1	5.2	2.5e-07	0.55	0.05	0.72	FALSE
10	GTEx	Nerve Tibial	PLA2G6	0.34	0.08	lasso	8	0.11	2.9e-08	-4.3	5.1	2.8e-07	0.76	0.24	0.76	FALSE
11	GTEx	Nerve Tibial	MAFF	0.14	0.06	lasso	3	0.05	1.2e-04	5.8	-5.7	1.2e-08	-0.82	0.02	0.97	FALSE
12	GTEx	Nerve Tibial	AL021977.1	0.16	0.05	lasso	3	0.07	9.3e-06	4.6	-5.3	1.2e-07	-0.61	0.26	0.72	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	SUN2	0.13	0.00	enet	36	0.02	2.9e-02	3.4	-5.4	8.8e-08	-0.11	0.41	0.10	TRUE
14	GTEx	Skin Sun Exposed Lower leg	BAIAP2L2	0.09	0.09	lasso	4	0.09	5.5e-08	5.1	-5.6	2.0e-08	-0.88	0.03	0.96	FALSE
15	GTEx	Spleen	SYNGR1	0.36	0.41	lasso	2	0.36	3.4e-10	5.8	5.7	1.2e-08	-0.05	0.00	1.00	TRUE
16	GTEx	Thyroid	TMEM184B	0.19	0.16	lasso	7	0.18	1.0e-13	4.7	-5.9	4.6e-09	-0.75	0.33	0.67	FALSE
17	GTEx	Thyroid	AL021977.1	0.20	0.11	lasso	6	0.12	2.7e-09	4.6	-5.7	1.2e-08	-0.69	0.36	0.64	FALSE
18	NTR	Blood	SYNGR1	0.03	0.03	enet	6	0.03	1.0e-10	5.8	5.4	5.2e-08	-0.04	0.00	1.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	TNRC6B	0.02	0.01	blup	92	0.01	2.7e-03	-4.3	-5.3	1.2e-07	-0.05	0.02	0.78	FALSE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADSL	0.04	0.03	enet	6	0.03	1.6e-04	-5.7	-5.1	2.6e-07	-0.02	0.00	0.94	FALSE
21	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLA2G6	0.05	0.01	blup	76	0.01	7.7e-02	5.9	5.3	1.4e-07	0.68	0.02	0.73	FALSE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	ADSL	0.03	0.00	blup	33	0.01	8.9e-03	-5.5	-5.4	5.9e-08	-0.06	0.01	0.62	FALSE
23	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ADSL	0.06	0.02	lasso	2	0.03	6.6e-03	-5.6	-5.5	3.8e-08	0.00	0.00	0.81	TRUE
24	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADSL	0.09	0.03	lasso	3	0.01	7.7e-02	-5.8	-5.5	3.9e-08	-0.04	0.00	0.76	FALSE
25	The Cancer Genome Atlas	Thyroid Carcinoma	PLA2G6	0.03	0.02	lasso	2	0.03	6.5e-04	5.2	5.2	1.9e-07	0.75	0.07	0.32	FALSE