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chr12:120,044,549-125,270,773

Best TWAS P=5.51e-32 · Best GWAS P=1.44e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	HIP1R	0.06	0.02	lasso	6	0.04	1.9e-05	-5.2	-5.6	2.2e-08	0.01	0.18	0.02	FALSE
2	GTEx	Adipose Subcutaneous	CCDC92	0.23	0.04	enet	27	0.16	6.9e-13	-6.8	10.9	8.3e-28	0.48	0.12	0.88	FALSE
3	GTEx	Adipose Subcutaneous	RP11-380L11.3	0.09	0.03	lasso	3	0.03	1.4e-03	9.3	11.6	4.4e-31	0.87	0.02	0.97	FALSE
4	GTEx	Adipose Subcutaneous	RP11-380L11.4	0.08	0.06	lasso	4	0.04	1.9e-04	6.4	5.9	3.4e-09	0.58	0.15	0.82	FALSE
5	GTEx	Adipose Visceral Omentum	CCDC92	0.19	0.02	lasso	8	0.09	3.3e-05	9.3	11.7	1.1e-31	0.63	0.03	0.96	TRUE
6	GTEx	Adipose Visceral Omentum	RP11-380L11.3	0.15	0.03	lasso	5	0.01	1.4e-01	7.6	11.8	5.5e-32	0.65	0.04	0.78	TRUE
7	GTEx	Artery Aorta	P2RX4	0.20	0.03	enet	28	0.05	1.6e-03	-3.8	-5.1	2.8e-07	0.04	0.06	0.78	TRUE
8	GTEx	Artery Tibial	SIRT4	0.30	0.14	lasso	8	0.14	4.3e-11	-5.5	-5.5	3.4e-08	-0.04	0.01	0.99	FALSE
9	GTEx	Artery Tibial	PITPNM2	0.11	0.05	lasso	4	0.04	2.7e-04	-5.3	5.8	4.9e-09	0.06	0.70	0.02	FALSE
10	GTEx	Artery Tibial	RP11-380L11.4	0.14	0.12	lasso	4	0.12	2.2e-09	9.3	9.2	2.7e-20	0.95	0.03	0.97	TRUE
11	GTEx	Brain Cerebellar Hemisphere	WDR66	0.28	0.05	lasso	8	0.04	3.6e-02	-4.5	-5.8	8.4e-09	-0.03	0.08	0.20	FALSE
12	GTEx	Brain Cerebellum	SIRT4	0.48	-0.01	enet	32	0.24	9.2e-08	-5.5	-5.2	2.1e-07	-0.10	0.02	0.86	FALSE
13	GTEx	Brain Putamen basal ganglia	WDR66	0.25	0.01	enet	16	-0.01	5.6e-01	5.7	-6.3	3.7e-10	0.01	0.06	0.21	FALSE
14	GTEx	Breast Mammary Tissue	SIRT4	0.19	0.16	lasso	6	0.16	1.4e-08	-5.5	-5.4	7.5e-08	-0.03	0.01	0.99	FALSE
15	GTEx	Breast Mammary Tissue (Male)	CCDC92	0.06	-0.01	lasso	3	0.00	4.3e-01	8.3	8.7	4.2e-18	0.85	0.04	0.14	FALSE
16	GTEx	Breast Mammary Tissue (Female)	KDM2B	0.13	0.00	lasso	3	0.01	1.2e-01	-4.0	5.5	3.1e-08	0.10	0.04	0.26	TRUE
17	GTEx	Breast Mammary Tissue (Female)	SIRT4	0.03	0.03	lasso	1	0.05	1.0e-02	-5.3	-5.3	1.4e-07	-0.05	0.02	0.60	FALSE
18	GTEx	Breast Mammary Tissue (Female)	CCDC92	0.05	-0.01	enet	2	-0.01	6.2e-01	8.2	8.2	1.9e-16	0.89	0.04	0.27	FALSE
19	GTEx	Breast Mammary Tissue (Female)	C12orf65	0.06	0.00	enet	13	-0.01	6.5e-01	-4.2	-5.8	5.0e-09	-0.08	0.04	0.28	FALSE
20	GTEx	Cells Transformed fibroblasts	BCL7A	0.06	0.01	lasso	4	0.01	3.1e-02	5.6	-8.5	1.6e-17	-0.04	0.09	0.05	TRUE
21	GTEx	Cells Transformed fibroblasts	CCDC92	0.09	0.00	enet	28	0.01	3.8e-02	7.2	5.8	5.2e-09	0.40	0.07	0.26	FALSE
22	GTEx	Colon Sigmoid	RP11-380L11.4	0.21	0.12	lasso	3	0.08	1.1e-03	9.2	9.4	4.8e-21	0.91	0.03	0.92	FALSE
23	GTEx	Colon Transverse	MLXIP	0.20	0.18	enet	23	0.14	5.8e-07	5.9	5.8	8.8e-09	-0.08	1.00	0.00	FALSE
24	GTEx	Colon Transverse	SNRNP35	0.18	0.02	lasso	8	0.04	6.5e-03	-4.0	7.3	2.5e-13	0.15	0.08	0.07	TRUE
25	GTEx	Esophagus Mucosa	KDM2B	0.11	0.04	enet	22	0.10	4.1e-07	3.2	6.8	1.3e-11	0.04	0.90	0.03	FALSE
26	GTEx	Esophagus Mucosa	CCDC92	0.11	0.02	lasso	4	0.02	1.9e-02	8.4	8.5	1.3e-17	0.89	0.08	0.82	FALSE
27	GTEx	Esophagus Mucosa	HIP1R	0.21	0.05	lasso	5	0.07	1.5e-05	4.5	7.5	5.9e-14	-0.05	0.47	0.26	TRUE
28	GTEx	Esophagus Muscularis	RP11-380L11.4	0.27	0.29	lasso	8	0.27	1.0e-16	9.3	9.3	1.4e-20	0.94	0.03	0.97	FALSE
29	GTEx	Heart Atrial Appendage	CCDC92	0.12	0.11	enet	9	0.11	1.1e-05	6.7	8.7	2.6e-18	0.79	0.05	0.93	FALSE
30	GTEx	Heart Atrial Appendage	RP11-380L11.4	0.18	0.11	lasso	7	0.12	6.5e-06	9.3	10.1	6.1e-24	0.92	0.02	0.97	FALSE
31	GTEx	Heart Left Ventricle	CCDC92	0.26	0.19	lasso	4	0.21	1.9e-11	8.4	10.0	2.0e-23	0.87	0.07	0.93	FALSE
32	GTEx	Lung	SIRT4	0.11	0.06	lasso	8	0.01	3.8e-02	-5.5	-5.5	4.0e-08	-0.03	0.01	0.99	FALSE
33	GTEx	Lung	CCDC92	0.14	0.00	enet	10	0.01	1.1e-01	8.3	8.7	2.6e-18	0.18	0.18	0.12	TRUE
34	GTEx	Lung	RP11-380L11.4	0.07	0.07	lasso	3	0.07	8.2e-06	9.4	9.2	3.2e-20	0.94	0.03	0.97	FALSE
35	GTEx	Muscle Skeletal	RSRC2	0.06	0.03	enet	7	0.04	9.6e-05	-2.8	-5.7	1.5e-08	-0.03	0.25	0.48	FALSE
36	GTEx	Muscle Skeletal	RP11-380L11.4	0.14	0.03	lasso	8	0.03	4.0e-04	9.3	7.9	2.8e-15	0.90	0.02	0.97	FALSE
37	GTEx	Nerve Tibial	SIRT4	0.23	0.21	lasso	5	0.20	4.6e-14	-5.2	-5.5	3.3e-08	-0.03	0.01	0.99	FALSE
38	GTEx	Nerve Tibial	CCDC92	0.16	0.01	enet	6	0.04	6.7e-04	8.1	9.4	3.7e-21	0.68	0.07	0.63	FALSE
39	GTEx	Nerve Tibial	KNTC1	0.12	0.05	lasso	5	0.05	1.9e-04	-5.8	-6.3	4.0e-10	0.02	0.53	0.03	FALSE
40	GTEx	Pancreas	SIRT4	0.40	0.37	lasso	7	0.37	1.8e-16	-5.3	-5.6	2.6e-08	-0.03	0.01	0.99	TRUE
41	GTEx	Pancreas	RP11-347I19.8	0.12	0.00	enet	13	0.00	2.9e-01	3.8	-5.2	1.7e-07	0.05	0.09	0.11	FALSE
42	GTEx	Prostate	CCDC92	0.31	0.10	enet	42	0.11	9.0e-04	8.2	7.3	4.1e-13	0.48	0.04	0.79	FALSE
43	GTEx	Skin Sun Exposed Lower leg	DDX55	0.13	0.05	enet	13	0.10	1.6e-08	-3.5	5.1	2.7e-07	0.07	1.00	0.00	FALSE
44	GTEx	Skin Sun Exposed Lower leg	CCDC92	0.11	0.00	enet	15	0.01	1.0e-01	7.2	6.6	3.2e-11	0.50	0.06	0.53	FALSE
45	GTEx	Skin Sun Exposed Lower leg	RP11-380L11.4	0.04	0.02	enet	15	0.02	1.9e-02	9.4	8.5	1.7e-17	0.83	0.02	0.95	FALSE
46	GTEx	Stomach	SIRT4	0.14	0.14	enet	8	0.09	3.1e-05	-5.2	-5.1	3.0e-07	-0.04	0.01	0.99	FALSE
47	GTEx	Stomach	RP11-347I19.8	0.22	0.09	lasso	7	0.11	4.2e-06	3.9	-5.3	1.5e-07	0.08	0.95	0.01	FALSE
48	GTEx	Thyroid	CCDC92	0.06	0.03	lasso	3	0.02	1.1e-02	9.3	10.5	8.6e-26	0.89	0.03	0.95	FALSE
49	GTEx	Thyroid	ZNF664	0.13	0.06	lasso	11	0.08	6.7e-07	8.2	-9.2	5.2e-20	-0.87	0.04	0.96	FALSE
50	GTEx	Whole Blood	DDX55	0.13	0.04	enet	13	0.06	3.3e-06	-3.4	5.7	1.0e-08	0.05	0.34	0.02	FALSE
51	METSIM	Adipose	ABCB9	0.04	0.03	enet	19	0.03	7.7e-05	-5.2	-7.3	3.2e-13	0.12	0.08	0.65	FALSE
52	METSIM	Adipose	CCDC92	0.10	0.01	bslmm	435	0.06	5.5e-10	-4.7	10.5	1.2e-25	0.62	0.19	0.81	FALSE
53	METSIM	Adipose	DNAH10	0.03	0.00	bslmm	475	0.01	3.2e-03	9.5	8.5	2.0e-17	0.66	0.02	0.90	FALSE
54	METSIM	Adipose	MORN3	0.06	0.02	lasso	10	0.04	8.7e-07	6.2	7.1	1.0e-12	0.01	0.03	0.97	FALSE
55	METSIM	Adipose	RP11-214K3.24	0.05	0.03	bslmm	444	0.02	2.7e-04	8.4	10.1	4.6e-24	0.73	0.04	0.94	FALSE
56	NTR	Blood	MORN3	0.02	0.01	lasso	4	0.01	1.2e-05	5.8	5.5	4.7e-08	0.02	0.03	0.97	FALSE
57	NTR	Blood	ZNF664	0.02	0.00	bslmm	447	0.01	6.3e-04	-5.1	-5.9	2.9e-09	-0.57	0.03	0.81	FALSE
58	YFS	Blood	MORN3	0.12	0.13	lasso	7	0.15	4.9e-48	6.2	5.8	6.0e-09	0.01	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNAH10	0.11	0.03	blup	99	0.05	8.2e-11	7.0	9.2	5.5e-20	0.71	0.02	0.98	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	SIRT4	0.06	0.06	lasso	4	0.05	2.8e-11	-5.5	-5.4	5.1e-08	-0.04	0.00	1.00	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	5.8	5.9	3.4e-09	-0.07	0.02	0.92	FALSE
62	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC92	0.07	0.02	blup	52	0.04	1.8e-02	8.2	8.8	2.1e-18	0.93	0.02	0.73	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC92	0.06	0.04	enet	8	0.05	1.7e-06	8.5	5.9	3.2e-09	0.75	0.07	0.91	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAH10	0.07	0.03	lasso	3	0.05	7.4e-06	9.4	9.1	1.3e-19	0.80	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC338799	0.04	0.02	blup	29	0.04	3.5e-05	3.9	-5.2	1.5e-07	0.07	0.02	0.32	FALSE
66	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLXIP	0.18	0.14	lasso	4	0.13	5.1e-04	5.2	5.6	2.8e-08	-0.08	0.02	0.88	FALSE
67	The Cancer Genome Atlas	Soft Tissue Sarcoma	CCDC92	0.05	0.03	blup	52	0.03	5.8e-03	3.9	7.4	1.4e-13	0.91	0.03	0.71	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	5.8	7.2	4.3e-13	-0.03	0.02	0.84	TRUE
69	The Cancer Genome Atlas	Thyroid Carcinoma	DNAH10	0.04	0.03	lasso	5	0.02	4.6e-03	8.1	8.7	4.1e-18	0.86	0.01	0.86	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	VPS33A	0.06	0.00	enet	8	0.03	9.6e-04	4.8	-5.9	4.1e-09	0.02	0.09	0.90	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF664	0.06	0.05	enet	9	0.05	2.8e-05	9.3	-9.3	1.9e-20	-0.92	0.02	0.98	FALSE