TWAS hub - CCDC78

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.214	0.075	0.0011	0.117	NA	0.118	NA	0.103	0.00065	NA	0.00062	NA	0.00130
2	TCGA	Thyroid Carcinoma	0.090	0.045	0.0012	0.034	0.028	0.024	NA	0.030	0.00025	0.00089	0.00200	NA	0.00059

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Comparative height size at age 10	10.1	55.7	100.0	-10.0	3.4
Height	9.5	183.3	338.6	-18.4	5.3
Standing height	9.4	93.5	156.2	-12.5	5.5
Trunk predicted mass	8.4	48.1	87.0	-9.3	3.0
Whole body fat-free mass	8.4	48.1	86.9	-9.3	3.0
Trunk fat-free mass	8.2	47.2	85.6	-9.2	3.0
Whole body water mass	8.1	46.2	83.5	-9.1	3.0
Arm predicted mass (right)	7.8	40.0	77.6	-8.8	1.5
Basal metabolic rate	7.8	43.0	80.1	-8.9	2.4
Leg fat-free mass (left)	7.7	40.6	75.2	-8.7	2.5
Leg predicted mass (left)	7.7	40.7	75.2	-8.7	2.5
Leg fat-free mass (right)	7.7	41.4	73.6	-8.6	3.0
Leg predicted mass (right)	7.6	40.6	72.6	-8.5	3.0
Arm fat-free mass (right)	7.5	38.7	74.3	-8.6	1.8
Sitting height	7.4	52.6	86.9	-9.3	4.3
Arm predicted mass (left)	7.1	36.3	69.2	-8.3	1.9
Arm fat-free mass (left)	6.6	33.7	64.2	-8.0	1.8
Number of incorrect matches in round	6.2	10.4	20.2	-4.5	0.7
Weight	6.1	30.0	58.8	-7.7	1.1
Hip circumference	5.6	24.0	46.4	-6.8	1.3
Loud music exposure frequency	5.6	6.2	12.2	3.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted	5.3	10.9	15.8	-4.0	2.5
Smoking status: Previous	4.9	7.4	14.1	3.8	-0.8
Alcohol intake frequency.	4.4	10.2	20.0	4.5	-0.5
Past tobacco smoking	4.3	7.9	15.1	-3.9	0.8
Qualifications: None of the above	4.2	9.0	14.4	1.9	-3.8
Illnesses of father: None of the above (group 1)	4.1	5.1	5.8	2.1	-2.4
Average weekly champagne plus white wine intake	4.1	5.6	8.7	-2.9	1.6
Trunk fat mass	3.7	15.8	31.6	-5.6	-0.2
Waist circumference	3.7	13.5	26.6	-5.2	-0.6
Forced vital capacity (FVC)	3.7	14.1	15.8	-3.5	4.0
Ever smoked	3.6	6.3	11.5	3.4	-1.0
Forced vital capacity (FVC), Best measure	3.3	12.2	13.8	-3.3	3.7
Medication: Bendroflumethiazide	3.3	5.0	7.9	-2.8	-1.4
Whole body fat mass	3.2	13.4	26.5	-5.2	-0.6
Age when periods started (menarche)	3.0	7.1	13.2	3.6	1.0
Peak expiratory flow (PEF)	3.0	6.9	7.7	-2.8	2.5
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	6.7	-0.7	-2.6
Happiness	2.9	3.6	4.9	-2.2	1.5
Mouth/teeth dental problems: Loose teeth	2.9	3.4	5.3	2.3	1.2
Mouth/teeth dental problems: Dentures	2.8	4.7	8.2	-1.1	-2.9
Medication: Blood pressure	2.8	5.3	10.4	-3.2	0.5
Chronotype (morning person)	2.7	6.3	7.8	-2.2	-2.8
Forced expiratory volume in 1-second (FEV1)	2.7	9.1	10.3	-2.8	3.2
Health satisfaction	2.7	3.5	6.9	-2.6	0.0
Leg fat mass (right)	2.7	10.5	16.7	-4.1	-2.0
Leg fat mass (left)	2.7	10.4	16.7	-4.1	-2.0
Hypothyroidism (self reported)	2.5	5.8	6.5	2.3	2.6
Qualifications: A levels/AS levels or equivalent	2.5	5.6	11.1	-0.1	3.3
Ever depressed for a whole week	2.5	3.0	4.4	-2.1	1.3
Townsend deprivation index at recruitment	2.4	3.4	5.8	2.4	-1.0
Illnesses of siblings	2.4	3.4	6.8	2.6	0.2
Number of children fathered	2.4	2.7	2.8	-1.7	-1.6
Illnesses of father: Heart disease	2.4	3.4	4.9	-2.2	1.4
Commuting to job workplace: Walk	2.4	2.6	3.7	1.9	-1.2
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	3.1	-1.6	1.8
Commuting to job workplace: Car/motor vehicle	2.3	2.6	3.1	-1.8	1.4
Tinnitus: Yes, now most or all of the time	2.3	2.7	3.2	1.5	-1.8
Age at First Birth	2.2	3.2	3.6	-1.9	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.1	8.0	-2.5	2.8
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	6.5	1.5	2.5
Age at first live birth	2.2	3.9	6.0	-2.5	1.4
Heart disease (mother)	2.2	2.6	5.0	-2.2	-0.5
Knee pain experienced in last month	2.2	3.5	5.2	1.4	-2.3
Loneliness, isolation	2.2	3.1	4.6	1.3	-2.1
Arm fat mass (left)	2.2	8.9	17.6	-4.2	-0.2
Ever taken oral contraceptive pill	2.2	2.5	4.4	2.1	0.7
Arm fat mass (right)	2.1	8.8	17.5	-4.2	-0.3
Leg fat percentage (right)	2.1	7.7	13.7	-1.3	-3.7
Long-standing illness, disability or infirmity	2.1	3.3	4.7	2.2	1.4
Blood Platelet Count	2.0	22.8	40.4	6.4	-2.3
Medication: Omeprazole	2.0	2.4	4.1	-0.9	-2.0
Mouth/teeth dental problems: Mouth ulcers	2.0	3.1	6.1	2.5	0.4
Asthma (self-reported)	2.0	4.1	5.0	2.2	1.8
Leg fat percentage (left)	2.0	7.2	12.7	-1.3	-3.6
Intelligence (Savage-Jansen 2018)	1.9	5.8	10.4	1.1	3.2
Schizophrenia (2014)	1.9	4.1	7.8	-2.8	-0.7
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	2.9	-1.1	1.7
Asthma	1.9	3.8	5.0	2.2	1.6
Hearing aid user	1.9	2.1	2.6	1.6	-1.3
Diastolic blood pressure, automated reading	1.9	5.9	7.9	-2.8	-1.9
Smoking Status	1.8	4.3	6.7	2.6	-1.4
Time employed in main current job	1.8	2.1	4.2	-2.0	-0.2
Falls in the last year	1.8	2.4	4.3	-2.1	0.7
Pulse wave Arterial Stiffness index	1.8	2.1	2.6	-1.2	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.8	2.8	5.6	0.1	2.4
Medication: Ventolin 100micrograms inhaler	1.8	2.3	2.3	1.5	1.5
Friendships satisfaction	1.8	2.3	2.5	-1.4	1.6
High blood pressure	1.7	4.7	9.1	-3.0	0.6
Medication: Atenolol	1.7	2.1	2.2	-1.4	-1.5
Alcohol drinker status: Previous	1.7	1.9	2.8	1.7	1.0
Reaction Time	1.6	3.1	3.2	-1.8	1.7
Systolic blood pressure, automated reading	1.6	4.7	8.8	-3.0	-0.8
Had other major operations	1.6	1.9	2.3	1.2	1.5
Allergy	1.6	3.8	5.2	-1.5	-2.3
Hair/balding pattern: Pattern 4	1.6	3.9	7.7	0.3	2.8
Impedance of leg (left)	1.5	7.2	10.8	3.3	-1.9
Alcohol intake versus 10 years previously	1.5	2.2	4.2	2.1	0.4
Worrier / anxious feelings	1.5	2.8	5.3	0.5	2.3
Qualifications: College or University degree	1.5	4.8	6.3	-1.8	2.5
Neck or shoulder pain in last month	1.5	2.1	4.2	2.1	0.2
Age at last live birth	1.5	2.1	3.0	-1.7	1.1
Osteoarthritis (self-reported)	1.5	1.9	2.2	1.5	-1.2
Mean Putamen Volume	1.4	1.6	2.2	1.5	1.0
Lung FVC	1.4	7.1	8.8	3.0	2.4
Average weekly spirits intake	1.4	1.7	3.3	-0.4	1.8
Trunk fat percentage	1.4	5.7	10.6	-3.2	-0.9
Hearing difficulty/problems with background noise	1.4	2.3	3.8	1.9	-0.9
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	4.2	-0.7	2.0
High blood pressure (siblings)	1.4	2.0	3.7	-1.9	-0.6
Hypertension (Self-reported)	1.4	4.0	7.8	-2.8	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	2.5	-1.6	-0.9
Guilty feelings	1.4	2.1	2.9	1.1	1.7
Ovarian Cancer	1.3	1.8	3.5	-0.2	-1.9
Crohns Disease (2012)	1.3	2.2	4.3	-2.1	0.0
Blood Eosinophil Count	1.3	9.9	14.3	-3.8	2.4
Severe depression (siblings)	1.3	1.5	2.9	1.7	-0.0
Fed-up feelings	1.3	2.3	4.0	2.0	-0.8
Pulse rate	1.3	2.2	3.9	2.0	-0.7
Pulse wave reflection index	1.3	1.6	1.7	-1.3	1.3
Medication: Amlodipine	1.3	1.9	2.7	-1.6	-1.0
Schizophrenia (2018)	1.2	2.5	4.0	-2.0	-1.0
Respiratory disease	1.2	2.7	4.2	2.1	1.1
Impedance of leg (right)	1.2	6.0	8.0	2.8	-2.0
Depression (self-reported)	1.2	1.5	2.9	-1.7	-0.3
Chronic bronchitis/emphysema (mother)	1.2	1.4	1.9	0.9	-1.4
Body fat percentage	1.2	4.6	5.8	-2.4	-1.9
Mean time to correctly identify matches	1.2	2.3	2.3	-1.5	1.5
Medication for cholesterol	1.2	1.8	3.6	1.9	-0.1
Unable to work because of sickness or disability	1.2	1.6	3.1	1.8	-0.2
Vascular/heart problems diagnosed by doctor	1.2	3.4	6.6	2.6	-0.4
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.9	1.7	0.6
Bipolar Disorder or Schizophrenia	1.1	2.7	4.8	-2.2	-0.7
Alzheimer’s Disease (including proxy)	1.1	1.6	3.2	1.8	-0.1
Cardiovascular Disease	1.1	3.5	7.0	-2.6	0.3
Supplements: Zinc	1.1	1.2	2.3	0.3	1.5
Diabetes (mother)	1.1	1.4	2.5	-0.5	1.6
Hayfever, allergic rhinitis or eczema	1.1	2.5	3.2	1.3	1.8
Diabetes diagnosed by doctor	1.1	1.9	2.8	-1.7	1.0
Medication for hormone replacement therapy	1.0	1.1	2.1	-1.4	-0.3
Diabetes (father)	1.0	1.2	2.3	1.5	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	1.5	1.1	1.2
Supplements: Glucosamine	1.0	1.4	1.6	1.3	1.1
Body mass index (BMI)	1.0	4.1	5.9	-2.4	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.0	0.3	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.3	1.8	-0.0
Medication: Allopurinol	1.0	1.4	2.3	-1.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.1	1.8	1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	4.2	0.3	2.0
Mother’s age at death	1.0	1.2	2.0	1.4	0.7
Illnesses of father: High blood pressure	1.0	1.3	2.3	-0.5	1.5
Commuting to job workplace: Cycle	1.0	1.2	2.3	-0.4	1.5
Supplements: Calcium	1.0	1.1	1.9	1.4	0.5
Prostate Cancer	0.9	1.3	2.4	-1.6	-0.4
Allergy or Eczema	0.9	2.4	4.0	2.0	1.0
Tanning	0.9	11.0	15.8	-4.0	-2.5
Qualifications: CSEs or equivalent	0.9	1.2	1.6	1.3	-0.9
Diabetes (self-reported)	0.9	1.5	2.8	-1.7	0.4
Fluid intelligence score	0.9	1.9	3.8	-0.2	1.9
Blood clot in the leg (DVT)	0.9	1.1	2.1	1.4	0.4
Medication: Blood pressure	0.9	1.7	2.8	-1.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.2	-1.5	-0.1
Pulse rate, automated reading	0.9	3.0	5.1	2.3	-0.9
Had major operations	0.9	1.0	2.0	0.2	-1.4
Breast cancer (self-reported)	0.9	1.1	1.1	-1.1	1.0
Commuting to job workplace: Public transport	0.9	1.1	1.9	0.5	1.4
Medication: Atorvastatin	0.9	1.1	2.1	-1.4	-0.3
Breast Cancer	0.8	2.0	4.0	2.0	-0.3
HDL Cholesterol	0.8	1.3	2.6	-1.6	0.0
Ever had hysterectomy (womb removed)	0.8	0.9	1.7	0.1	-1.3
Medication: Levothyroxine sodium	0.8	1.4	1.8	1.0	1.3
Hair/balding pattern: Pattern 2	0.8	1.1	2.0	-1.4	-0.3
Worry (Nagel 2018)	0.7	1.4	2.8	-0.2	1.7
Fasting Glucose	0.7	0.8	0.9	0.9	-0.8
Blood Red Count	0.7	6.4	8.1	-2.9	-2.2
Systolic Blood Pressure	0.7	3.4	6.9	-2.6	-0.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.6	0.4	1.3
Number of live births	0.7	1.0	1.9	1.4	-0.1
Medication: Cholesterol lowering	0.7	1.1	1.8	-0.6	-1.3
Prospective memory result	0.7	0.9	1.7	0.3	-1.3
Tense / ‘highly strung’	0.7	1.2	2.3	-1.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	1.8	0.8	1.4
Pulse wave peak to peak time	0.7	0.8	1.4	0.3	-1.2
Medication: Ibuprofen	0.7	0.8	1.2	-1.1	0.7
Number of operations (self-reported)	0.7	1.0	2.0	1.4	0.3
Pain experienced in last month	0.7	1.1	1.9	-1.4	0.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.0	1.0	-0.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	1.1	0.2
Alzheimer’s Disease (in father)	0.6	0.7	0.8	0.9	0.7
Irritable Bowel Disease (IBD)	0.6	1.5	1.6	-1.3	1.1
Verbal and Numeric Reasoning (VNR)	0.6	1.5	3.0	0.3	1.7
Waist Hip Ratio (WHR)	0.6	2.8	5.3	-0.5	-2.3
Hand grip strength (left)	0.6	1.6	1.7	-1.2	1.3
Hearing difficulty/problems: Yes	0.6	0.9	1.7	0.3	-1.3
Maternal smoking around birth	0.6	0.9	1.8	1.4	-0.2
Taking other prescription medications	0.6	0.9	1.0	-1.0	0.9
Heart attack	0.6	0.7	1.1	1.0	-0.6
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	0.3	1.3
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.5	1.2	0.2
Financial situation satisfaction	0.6	0.8	1.3	0.5	1.1
Age started oral contraceptive pill	0.6	0.7	1.3	-1.1	-0.4
Heart disease (siblings)	0.6	0.8	1.2	-1.1	-0.5
Pack years of smoking	0.6	0.9	1.5	-1.2	-0.6
HbA1C	0.5	0.6	0.9	0.9	-0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.7	-0.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	-0.3	1.0
Alcohol usually taken with meals	0.5	0.8	1.2	-1.1	-0.6
Impedance of arm (right)	0.5	2.5	2.6	1.6	1.6
Father’s age at death	0.5	0.7	0.7	-0.8	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.8	-0.8	0.9
Illnesses of mother	0.5	0.6	1.2	0.1	1.1
Impedance of arm (left)	0.5	2.3	3.1	1.3	1.8
Length of working week for main job	0.5	0.5	0.7	-0.9	0.5
Birth weight	0.5	1.1	2.2	1.5	0.3
Wheeze or whistling in the chest in last year	0.5	0.9	1.6	0.4	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.1	0.0	-1.0
Number of full sisters	0.5	0.6	0.8	0.9	-0.7
Leg pain on walking	0.5	0.6	1.1	-1.0	0.3
Arm fat percentage (left)	0.5	2.2	3.3	-1.8	-1.0
Handedness (chirality/laterality): Left-handed	0.5	0.5	1.1	-1.0	0.1
Medication: Lisinopril	0.5	0.6	1.1	-1.0	0.4
Crohns Disease (2017)	0.4	0.9	1.8	-1.3	0.4
Ulcerative Colitis (UC)	0.4	0.7	1.3	-0.2	1.1
LDL Cholesterol	0.4	0.6	1.2	1.1	0.0
Primary Biliary Cirrhosis	0.4	0.6	0.8	-0.9	-0.6
BMI	0.4	2.2	3.0	-1.7	-1.2
Lung FEV1/FVC ratio	0.4	2.2	4.3	-0.4	-2.1
Number of treatments/medications taken	0.4	0.7	1.1	-0.5	1.0
Sensitivity / hurt feelings	0.4	0.6	0.9	-0.9	0.6
Angina	0.4	0.5	0.6	-0.6	-0.8
Vitamin and mineral supplements	0.4	0.5	0.8	0.5	-0.9
Medication: Metformin	0.4	0.5	0.5	-0.7	-0.7
Pack years adult smoking proportion	0.4	0.6	0.6	-0.8	-0.7
Hand grip strength (right)	0.4	1.0	2.0	0.1	1.4
Average weekly fortified wine intake	0.4	0.5	0.6	0.6	0.7
Multivitamins +/- minerals	0.4	0.5	1.1	-1.0	0.1
High blood pressure (mother)	0.4	0.5	1.1	0.1	-1.0
Mouth/teeth dental problems	0.4	0.6	1.2	-1.1	0.0
Medication: Ramipril	0.4	0.6	0.6	-0.7	0.8
Arm fat percentage (right)	0.4	1.5	2.1	-1.4	-0.9
Exposure to tobacco smoke at home	0.4	0.5	0.6	0.7	-0.6
Breastfed as a baby	0.4	0.5	0.8	0.3	0.9
Gout (self-reported)	0.4	0.6	1.1	-1.1	-0.2
Comparative body size at age 10	0.4	1.0	1.9	0.4	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.6	-0.9
Angina (self-reported)	0.4	0.5	0.5	-0.7	-0.7
Medication: Seretide 50 evohaler	0.4	0.4	0.9	-0.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.6	-0.6	0.7
Osteoporosis (self-reported)	0.4	0.5	0.7	0.8	-0.6
High cholesterol (Self-reported)	0.4	0.7	1.1	-1.1	-0.5
Irritability	0.4	0.7	1.5	0.1	1.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.6	0.8	0.5
Impedance of whole body	0.4	2.2	4.5	2.1	-0.0
Bipolar Disorder (2018)	0.3	0.5	1.0	-1.0	0.1
Depressed Affect (Nagel 2018)	0.3	0.7	0.8	0.9	-0.8
Neuroticism (Nagel 2018)	0.3	0.8	1.0	1.0	0.7
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.8	0.9	0.3
Relative age of first facial hair	0.3	0.5	0.9	-0.9	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	-0.5	0.7
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	0.2	0.9
Number of full brothers	0.3	0.4	0.6	-0.5	-0.8
Migraine (self-reported)	0.3	0.3	0.5	-0.4	0.7
Chest pain or discomfort	0.3	0.4	0.8	0.2	0.9
Supplements: Vitamin C	0.3	0.4	0.7	0.0	0.9
Number of self-reported non-cancer illnesses	0.3	0.5	0.9	-0.3	0.9
Average weekly beer plus cider intake	0.3	0.5	0.9	-1.0	-0.1
Rheumatoid Arthritis	0.2	0.2	0.4	-0.6	0.3
Ulcerative Colitis	0.2	0.3	0.5	0.0	0.7
Blood White Count	0.2	1.3	2.2	0.6	-1.5
Heel T-Score	0.2	1.4	1.9	0.9	-1.4
Medication: Co-codamol	0.2	0.3	0.4	-0.3	-0.7
Current tobacco smoking	0.2	0.3	0.5	0.7	-0.4
Relative age voice broke	0.2	0.3	0.5	-0.7	-0.2
Nervous feelings	0.2	0.5	0.8	-0.4	0.9
Had menopause	0.2	0.3	0.5	-0.7	-0.2
Pain all over the body in last month	0.2	0.2	0.2	0.4	-0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.4	-0.7	0.3
Glaucoma (self-reported)	0.2	0.2	0.3	-0.3	0.6
Medication: Aspirin	0.2	0.2	0.4	0.7	-0.2
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.1	0.7
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.3	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	0.2	0.6
Back pain experienced in last month	0.2	0.3	0.6	0.8	-0.2
Medication: Gliclazide	0.2	0.3	0.5	0.7	0.0
Miserableness	0.2	0.4	0.7	0.9	0.3
Wears glasses or contact lenses	0.2	0.3	0.6	0.0	0.8
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.2	0.7
Cholesterol lowering medication	0.2	0.4	0.6	-0.8	-0.3
Depression (Nagel 2018)	0.1	0.2	0.3	0.5	-0.3
Lupus	0.1	0.1	0.2	0.5	-0.1
Neuroticism (2016)	0.1	0.1	0.2	0.4	0.1
Neuroticism	0.1	0.3	0.4	0.6	-0.5
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.5	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.2	0.3	-0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.1	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	0.3	-0.4
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.0	-0.4
Medication: Simvastatin	0.1	0.1	0.2	-0.4	-0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.2	-0.4	-0.5
Noisy workplace	0.1	0.2	0.2	-0.5	-0.3
Medication: Lansoprazole	0.1	0.1	0.2	-0.5	-0.1
Lung cancer (father)	0.1	0.1	0.2	0.4	-0.3
Birth weight of first child	0.1	0.2	0.4	-0.0	0.6
Headache pain in last month	0.1	0.1	0.2	0.4	-0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.4	0.2
Worry too long after embarrassment	0.1	0.2	0.5	0.7	0.0
Shortness of breath walking on level ground	0.1	0.1	0.1	0.3	0.1
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.5	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.1	-0.4
Suffer from ‘nerves’	0.1	0.1	0.2	0.4	-0.1
Overall health rating	0.1	0.1	0.2	0.1	-0.5
Family relationship satisfaction	0.1	0.2	0.3	0.5	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.2	-0.3
Mood swings	0.1	0.2	0.5	-0.2	-0.7
Ever had bowel cancer screening	0.1	0.1	0.1	-0.3	0.1
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	-0.4
Smoking status: Current	0.1	0.2	0.5	0.7	-0.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	0.1	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.2	-0.6
Medication: Paracetamol	0.1	0.1	0.3	-0.5	-0.0
Fractured/broken bones in last 5 years	0.1	0.2	0.3	-0.3	-0.5
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.0	0.0	0.1	0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	-0.0	-0.0
Hair Pigment	0.0	1.1	1.1	-1.1	-1.0
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.1	0.1
Neuroticism score	0.0	0.0	0.0	0.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	-0.1	-0.0
Medication: Paracetamol	0.0	0.0	0.0	0.2	0.0
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	-0.2	0.1
Average weekly red wine intake	0.0	0.0	0.0	0.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	0.2	-0.1
Medication: Aspirin	0.0	0.0	0.0	0.2	-0.2
Alcohol drinker status: Never	0.0	0.0	0.0	-0.1	-0.0
Risk taking	0.0	0.0	0.0	0.0	0.1
Myopia	0.0	0.0	0.1	0.2	-0.1
Basal cell carcinoma (self-reported)	0.0	0.0	0.1	0.2	-0.2

Hub : Genes

CCDC78

Models

Trait associations