[Hub]/) : Traits : Whole body fat-free mass : ← →

chr19:46,276,056-51,224,297

Best TWAS P=5.44e-13 · Best GWAS P=6.09e-25 conditioned to 5.66e-11

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
17	METSIM	Adipose	SAE1	0.12	0.04	lasso	5	0.07	1.7e-10	-5.0	-7.2	5.4e-13	0.61	0.61	0.39	TRUE
8	GTEx	Esophagus Mucosa	AP2A1	0.18	0.09	enet	8	0.13	7.7e-09	-5.4	-6.6	5.5e-11	-0.01	0.02	0.98	TRUE
14	GTEx	Testis	NTN5	0.16	0.02	enet	23	0.06	9.6e-04	-3.4	-6.0	1.7e-09	-0.02	0.03	0.77	TRUE
22	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GRLF1	0.04	0.04	blup	51	0.03	7.0e-05	4.7	6.0	2.0e-09	-0.04	0.45	0.06	TRUE
6	GTEx	Colon Sigmoid	PRR12	0.20	0.01	lasso	8	0.00	4.9e-01	3.6	5.8	7.4e-09	0.02	0.04	0.30	TRUE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	LIN7B	0.02	0.00	enet	7	0.02	5.1e-05	5.0	-5.7	1.2e-08	-0.04	0.01	0.92	TRUE
16	METSIM	Adipose	PNMAL1	0.24	0.27	bslmm	380	0.28	2.9e-41	5.2	5.2	1.9e-07	-0.01	0.00	1.00	TRUE
11	GTEx	Skin Sun Exposed Lower leg	CCDC9	0.13	0.00	lasso	5	0.00	2.2e-01	1.8	-5.2	2.6e-07	0.23	0.11	0.21	TRUE
4	GTEx	Cells EBV-transformed lymphocytes	SAE1	0.21	0.09	lasso	3	0.07	2.0e-03	-5.1	-6.7	2.3e-11	0.77	0.06	0.67	FALSE
10	GTEx	Nerve Tibial	AP2A1	0.16	0.05	lasso	4	0.07	1.3e-05	-5.5	-6.5	9.0e-11	0.02	0.01	0.99	FALSE
5	GTEx	Cells Transformed fibroblasts	TBC1D17	0.11	0.03	enet	23	0.04	6.5e-04	-5.0	6.3	3.3e-10	-0.02	0.13	0.84	FALSE
13	GTEx	Stomach	VRK3	0.10	-0.01	enet	10	-0.01	7.3e-01	3.6	6.0	2.1e-09	0.00	0.05	0.40	FALSE
18	YFS	Blood	SAE1	0.07	0.02	enet	18	0.05	3.6e-16	-8.7	-6.0	2.4e-09	0.56	0.99	0.01	FALSE
12	GTEx	Skin Sun Exposed Lower leg	AP2A1	0.15	0.08	enet	10	0.07	1.9e-06	-5.5	-5.7	9.5e-09	-0.01	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	SNRNP70	0.05	0.02	lasso	3	0.02	2.9e-02	4.4	-5.6	1.7e-08	-0.02	0.01	0.65	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP2A1	0.04	0.03	lasso	4	0.04	1.8e-08	-5.5	5.5	4.2e-08	-0.02	0.00	1.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PNKP	0.15	0.16	enet	23	0.16	7.0e-19	-5.4	-5.4	6.5e-08	0.03	0.22	0.78	FALSE
15	GTEx	Whole Blood	PNKP	0.14	0.10	enet	12	0.12	1.5e-11	-5.1	-5.2	2.1e-07	-0.04	0.30	0.70	FALSE
3	GTEx	Adipose Visceral Omentum	PNMAL1	0.18	0.15	lasso	2	0.14	9.7e-08	5.2	5.2	2.2e-07	-0.02	0.00	0.99	FALSE
9	GTEx	Muscle Skeletal	AKT1S1	0.10	0.09	lasso	3	0.08	1.9e-08	-5.2	5.2	2.2e-07	-0.05	0.32	0.68	FALSE
7	GTEx	Colon Transverse	PNMAL1	0.35	0.28	lasso	4	0.27	2.0e-13	5.2	5.2	2.4e-07	-0.02	0.00	1.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LIN7B	0.08	0.08	lasso	3	0.08	8.5e-10	-5.1	-5.2	2.6e-07	-0.04	0.05	0.94	FALSE