[Hub]/) : Traits : Impedance of leg (left) : ← →

chr16:66,737,479-71,513,034

Best TWAS P=6.77e-10 · Best GWAS P=4.03e-11 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	PRMT7	0.19	0.14	enet	5	0.15	6.9e-17	5.8	6.2	6.8e-10	0.01	0.00	1.00	TRUE
16	GTEx	Brain Hippocampus	EXOSC6	0.17	0.06	lasso	4	0.03	6.7e-02	5.1	6.1	1.1e-09	0.25	0.05	0.09	TRUE
11	GTEx	Brain Cerebellar Hemisphere	PDXDC2P	0.33	0.16	enet	11	0.27	1.4e-07	5.1	5.8	5.5e-09	0.45	0.54	0.18	TRUE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HYDIN	0.02	0.00	blup	61	0.02	2.6e-03	4.7	5.8	6.0e-09	0.05	0.03	0.79	TRUE
32	GTEx	Muscle Skeletal	RP11-296I10.6	0.11	0.15	enet	16	0.15	1.8e-14	5.0	5.7	1.0e-08	0.29	0.69	0.31	TRUE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZDHHC1	0.02	0.01	lasso	1	0.01	2.4e-03	-5.6	5.5	2.8e-08	0.02	0.01	0.85	TRUE
38	GTEx	Pituitary	ZDHHC1	0.23	0.13	lasso	4	0.08	4.0e-03	-4.0	-5.5	3.5e-08	-0.05	0.04	0.43	TRUE
47	GTEx	Testis	RP11-67A1.2	0.20	0.02	lasso	6	0.09	8.3e-05	4.4	5.4	5.6e-08	0.05	0.55	0.20	TRUE
7	GTEx	Adrenal Gland	EXOSC6	0.22	0.18	enet	6	0.17	1.1e-06	5.0	5.4	6.7e-08	0.22	0.59	0.28	TRUE
49	GTEx	Uterus	PDXDC2P	0.31	0.20	enet	28	0.24	1.3e-05	4.0	5.4	7.6e-08	0.40	0.06	0.50	TRUE
53	METSIM	Adipose	EXOSC6	0.30	0.24	bslmm	194	0.25	5.8e-37	5.1	5.4	8.1e-08	0.24	0.67	0.33	TRUE
56	METSIM	Adipose	RLTPR	0.04	0.00	bslmm	211	0.00	1.1e-01	-5.5	-5.3	8.8e-08	-0.06	0.03	0.79	TRUE
41	GTEx	Skin Sun Exposed Lower leg	NFATC3	0.06	0.04	enet	9	0.05	6.6e-05	-5.1	5.3	1.4e-07	-0.09	0.13	0.62	TRUE
36	GTEx	Ovary	PDXDC2P	0.45	0.11	lasso	7	0.28	1.6e-07	-3.2	5.2	1.5e-07	0.39	0.50	0.16	TRUE
54	METSIM	Adipose	NOB1	0.03	0.03	lasso	2	0.03	2.8e-05	-4.8	5.2	1.5e-07	0.76	0.07	0.92	TRUE
50	GTEx	Whole Blood	ATP6V0D1	0.08	0.00	enet	13	0.00	3.6e-01	-4.2	5.2	1.6e-07	0.02	0.04	0.83	TRUE
14	GTEx	Brain Cerebellum	EXOSC6	0.31	0.24	enet	23	0.22	5.7e-07	5.0	5.2	2.0e-07	0.22	0.63	0.29	TRUE
75	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HYDIN	0.09	0.02	blup	61	0.06	7.7e-04	4.7	5.2	2.1e-07	0.05	0.03	0.71	TRUE
65	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PDXDC2	0.06	0.02	blup	26	0.06	9.7e-06	5.1	5.1	3.0e-07	0.39	0.02	0.95	TRUE
18	GTEx	Brain Nucleus accumbens basal ganglia	RP11-296I10.6	0.15	0.11	lasso	3	0.08	3.0e-03	5.0	6.0	2.3e-09	0.38	0.08	0.40	FALSE
12	GTEx	Brain Cerebellar Hemisphere	EXOSC6	0.51	0.15	lasso	11	0.26	2.9e-07	5.1	6.0	2.6e-09	0.40	0.46	0.30	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	EXOSC6	0.22	0.12	enet	12	0.12	3.3e-04	5.1	5.9	3.5e-09	0.37	0.26	0.18	FALSE
37	GTEx	Ovary	RP11-296I10.6	0.35	0.28	enet	18	0.27	2.2e-07	5.1	5.9	4.1e-09	0.46	0.28	0.42	FALSE
45	GTEx	Testis	NFATC3	0.23	0.16	lasso	7	0.17	6.0e-08	4.4	5.9	4.1e-09	0.02	0.66	0.32	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PRMT7	0.23	0.19	bslmm	319	0.19	2.2e-22	5.7	5.8	5.2e-09	-0.01	0.00	1.00	FALSE
35	GTEx	Nerve Tibial	RP11-296I10.6	0.32	0.40	enet	23	0.43	5.1e-33	5.0	5.7	1.1e-08	0.26	0.71	0.28	FALSE
52	GTEx	Whole Blood	RP11-296I10.6	0.08	0.07	enet	16	0.09	2.3e-08	5.1	5.7	1.3e-08	0.23	0.64	0.36	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	PRMT7	0.05	0.05	lasso	1	0.04	5.3e-06	5.7	5.7	1.5e-08	0.00	0.00	0.99	FALSE
59	NTR	Blood	EXOSC6	0.06	0.07	bslmm	195	0.07	2.7e-22	5.0	5.6	1.9e-08	0.32	0.66	0.34	FALSE
3	CommonMind	Brain Pre-frontal Cortex	WWP2	0.10	0.04	bslmm	274	0.06	4.4e-08	4.9	-5.6	2.0e-08	-0.39	0.97	0.02	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EXOSC6	0.24	0.25	enet	14	0.24	1.5e-29	5.2	5.6	2.6e-08	0.28	0.64	0.35	FALSE
4	GTEx	Adipose Subcutaneous	EXOSC6	0.27	0.28	enet	26	0.32	3.1e-27	5.0	5.6	2.7e-08	0.27	0.69	0.31	FALSE
72	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EXOSC6	0.17	0.17	enet	5	0.17	9.2e-10	5.2	5.5	2.8e-08	0.24	0.00	1.00	FALSE
8	GTEx	Adrenal Gland	RP11-296I10.6	0.13	0.09	enet	18	0.04	1.4e-02	5.1	5.5	3.6e-08	0.15	0.26	0.16	FALSE
82	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NFATC3	0.23	0.05	enet	17	0.06	1.5e-03	-3.0	5.5	3.7e-08	0.03	0.01	0.08	FALSE
22	GTEx	Cells Transformed fibroblasts	EXOSC6	0.18	0.19	enet	12	0.23	2.1e-17	5.1	5.5	4.0e-08	0.26	0.64	0.36	FALSE
46	GTEx	Testis	RP11-296I10.6	0.10	0.04	enet	7	0.07	6.2e-04	5.1	5.5	4.3e-08	0.27	0.16	0.20	FALSE
10	GTEx	Artery Tibial	EXOSC6	0.27	0.32	enet	10	0.30	5.5e-24	5.1	5.5	4.4e-08	0.25	0.65	0.35	FALSE
84	The Cancer Genome Atlas	Rectum Adenocarcinoma	LRRC36	0.13	0.12	lasso	14	0.11	1.4e-03	-5.5	-5.5	4.5e-08	-0.03	0.01	0.66	FALSE
27	GTEx	Esophagus Muscularis	EXOSC6	0.30	0.33	enet	13	0.37	6.7e-24	5.1	5.5	4.8e-08	0.21	0.66	0.34	FALSE
48	GTEx	Thyroid	ZDHHC1	0.07	0.03	lasso	6	0.02	1.6e-02	-5.3	-5.5	5.0e-08	-0.02	0.01	0.96	FALSE
23	GTEx	Cells Transformed fibroblasts	RP11-296I10.6	0.10	0.09	enet	9	0.10	6.1e-08	5.1	5.4	5.3e-08	0.28	0.67	0.32	FALSE
79	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PRMT7	0.15	0.18	lasso	4	0.18	1.4e-20	5.7	5.4	5.3e-08	0.00	0.00	1.00	FALSE
21	GTEx	Cells Transformed fibroblasts	PDXDC2P	0.25	0.10	enet	15	0.21	1.5e-15	4.9	5.4	5.4e-08	0.35	0.99	0.01	FALSE
31	GTEx	Muscle Skeletal	EXOSC6	0.28	0.32	enet	20	0.32	4.2e-32	5.1	5.4	6.5e-08	0.26	0.66	0.34	FALSE
20	GTEx	Breast Mammary Tissue (Female)	EXOSC6	0.52	0.26	enet	21	0.27	1.4e-08	5.1	5.4	6.8e-08	0.36	0.57	0.30	FALSE
42	GTEx	Skin Sun Exposed Lower leg	EXOSC6	0.21	0.21	enet	10	0.22	3.9e-18	5.1	5.4	7.1e-08	0.25	0.67	0.33	FALSE
5	GTEx	Adipose Subcutaneous	RP11-296I10.6	0.30	0.27	lasso	7	0.31	8.4e-26	5.1	5.4	7.3e-08	0.26	0.66	0.34	FALSE
25	GTEx	Colon Transverse	EXOSC6	0.32	0.31	enet	8	0.31	2.1e-15	5.0	5.4	7.3e-08	0.23	0.68	0.32	FALSE
29	GTEx	Heart Atrial Appendage	RP11-296I10.6	0.18	0.19	enet	16	0.16	1.1e-07	5.1	5.4	7.7e-08	0.27	0.69	0.31	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HYDIN	0.08	0.03	blup	61	0.03	2.2e-02	4.7	5.4	8.1e-08	0.06	0.03	0.57	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	EXOSC6	0.09	0.13	enet	5	0.13	4.2e-15	5.2	5.4	8.5e-08	0.27	0.00	1.00	FALSE
63	YFS	Blood	PDPR	0.02	0.00	enet	20	0.01	1.8e-05	1.9	-5.3	8.8e-08	-0.47	0.05	0.08	FALSE
19	GTEx	Brain Putamen basal ganglia	RP11-296I10.6	0.24	0.01	enet	18	0.04	3.2e-02	5.0	5.3	9.0e-08	0.39	0.15	0.37	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	PDXDC2	0.15	0.25	enet	12	0.29	8.2e-33	4.8	5.3	9.8e-08	0.44	0.02	0.98	FALSE
24	GTEx	Colon Sigmoid	RP11-296I10.6	0.32	0.33	enet	20	0.33	2.2e-12	5.1	5.3	1.1e-07	0.20	0.69	0.31	FALSE
30	GTEx	Lung	NFATC3	0.04	0.01	lasso	4	0.01	4.1e-02	-4.8	5.3	1.1e-07	-0.09	0.10	0.67	FALSE
57	NTR	Blood	ATP6V0D1	0.02	0.01	bslmm	220	0.01	1.6e-04	-4.3	5.3	1.1e-07	0.00	0.13	0.75	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	LRRC36	0.04	0.04	lasso	3	0.04	1.5e-04	-5.3	-5.3	1.1e-07	-0.02	0.01	0.98	FALSE
15	GTEx	Brain Cerebellum	RP11-296I10.6	0.18	0.21	lasso	2	0.18	5.8e-06	5.0	5.3	1.2e-07	0.25	0.49	0.28	FALSE
28	GTEx	Esophagus Muscularis	RP11-296I10.6	0.32	0.27	enet	24	0.32	4.0e-20	5.0	5.3	1.2e-07	0.21	0.74	0.26	FALSE
34	GTEx	Nerve Tibial	EXOSC6	0.28	0.37	enet	10	0.41	1.1e-30	5.0	5.3	1.2e-07	0.22	0.70	0.30	FALSE
43	GTEx	Skin Sun Exposed Lower leg	RP11-296I10.6	0.20	0.25	enet	15	0.24	8.4e-20	5.1	5.3	1.2e-07	0.22	0.67	0.33	FALSE
60	YFS	Blood	ATP6V0D1	0.14	0.18	lasso	15	0.20	1.8e-63	-5.2	5.3	1.2e-07	0.02	0.02	0.97	FALSE
68	The Cancer Genome Atlas	Colon Adenocarcinoma	EXOSC6	0.15	0.13	lasso	2	0.12	1.5e-07	5.2	5.3	1.3e-07	0.25	0.00	1.00	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	ZDHHC1	0.07	0.06	enet	7	0.07	2.9e-07	-5.3	-5.3	1.3e-07	-0.03	0.02	0.98	FALSE
9	GTEx	Artery Coronary	EXOSC6	0.29	0.24	enet	10	0.20	2.1e-07	5.0	5.3	1.4e-07	0.22	0.66	0.33	FALSE
6	GTEx	Adipose Visceral Omentum	EXOSC6	0.26	0.29	lasso	6	0.32	3.3e-17	5.0	5.2	1.5e-07	0.31	0.73	0.27	FALSE
61	YFS	Blood	EXOSC6	0.24	0.24	lasso	5	0.25	2.4e-81	5.0	5.2	1.6e-07	0.27	0.64	0.35	FALSE
64	YFS	Blood	ZDHHC1	0.05	0.05	enet	26	0.05	1.8e-16	-5.3	-5.2	1.7e-07	-0.02	0.03	0.97	FALSE
51	GTEx	Whole Blood	EXOSC6	0.14	0.12	enet	10	0.11	3.5e-10	5.1	5.2	1.8e-07	0.21	0.69	0.31	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	RP11-296I10.6	0.21	0.24	enet	17	0.24	1.4e-13	5.1	5.2	1.9e-07	0.22	0.68	0.32	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	EXOSC6	0.19	0.23	enet	3	0.21	1.2e-21	5.2	5.2	1.9e-07	0.24	0.00	1.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	RP11-296I10.6	0.19	0.20	lasso	5	0.19	1.5e-05	5.1	5.2	2.1e-07	0.24	0.25	0.30	FALSE
26	GTEx	Esophagus Mucosa	EXOSC6	0.12	0.20	enet	5	0.19	1.6e-12	5.0	5.2	2.2e-07	0.22	0.70	0.30	FALSE
62	YFS	Blood	NFATC3	0.13	0.07	enet	36	0.10	7.1e-31	4.3	5.2	2.2e-07	0.03	0.74	0.24	FALSE
69	The Cancer Genome Atlas	Glioblastoma Multiforme	EXOSC6	0.18	0.25	lasso	1	0.23	1.2e-07	5.2	5.2	2.2e-07	0.22	0.00	1.00	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AARS	0.05	0.02	enet	6	0.03	9.8e-03	5.2	-5.2	2.2e-07	-0.13	0.00	0.56	FALSE
80	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EXOSC6	0.43	0.27	lasso	2	0.26	1.7e-11	5.2	5.2	2.2e-07	0.22	0.00	1.00	FALSE
44	GTEx	Spleen	RP11-296I10.6	0.30	0.20	enet	12	0.16	5.5e-05	5.1	5.2	2.3e-07	0.22	0.43	0.27	FALSE
33	GTEx	Nerve Tibial	PDXDC2P	0.40	0.24	lasso	9	0.43	9.9e-33	4.9	5.2	2.5e-07	0.32	0.99	0.01	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXOSC6	0.08	0.08	lasso	2	0.08	2.8e-15	5.2	5.2	2.5e-07	0.22	0.00	1.00	FALSE
58	NTR	Blood	ESRP2	0.03	0.03	lasso	5	0.02	7.7e-08	4.3	-5.1	2.9e-07	0.01	0.60	0.39	FALSE
39	GTEx	Prostate	RP11-296I10.6	0.20	0.18	lasso	4	0.19	1.9e-05	5.1	5.1	3.1e-07	0.22	0.22	0.17	FALSE
55	METSIM	Adipose	PLA2G15	0.03	0.01	blup	287	0.01	4.8e-03	-5.1	-5.1	3.1e-07	0.06	0.06	0.74	FALSE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	ATP6V0D1	0.04	0.02	blup	33	0.03	4.7e-04	-4.3	5.1	3.1e-07	0.02	0.02	0.96	FALSE