[Hub]/) : Traits : Leg fat percentage (right) : ← →

chr12:120,976,371-125,270,773

Best TWAS P=1.09e-18 · Best GWAS P=1.11e-14 conditioned to 4.25e-29

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Adipose Visceral Omentum	RP11-380L11.3	0.15	0.03	lasso	5	0.01	1.4e-01	6.005	8.8	1.1e-18	-0.08	0.03	0.79	TRUE
4	GTEx	Adipose Visceral Omentum	CCDC92	0.19	0.02	lasso	8	0.09	3.3e-05	6.681	8.7	5.1e-18	-0.12	0.02	0.97	TRUE
13	GTEx	Cells Transformed fibroblasts	BCL7A	0.06	0.01	lasso	4	0.01	3.1e-02	5.273	-7.4	1.8e-13	0.24	0.09	0.05	TRUE
19	GTEx	Esophagus Mucosa	HIP1R	0.21	0.05	lasso	5	0.07	1.5e-05	4.084	7.1	1.7e-12	-0.21	0.47	0.26	TRUE
24	GTEx	Lung	CCDC92	0.14	0.00	enet	10	0.01	1.1e-01	6.372	6.8	1.0e-11	-0.08	0.14	0.32	TRUE
16	GTEx	Colon Transverse	SNRNP35	0.18	0.02	lasso	8	0.04	6.5e-03	-3.959	6.7	2.1e-11	-0.16	0.08	0.07	TRUE
8	GTEx	Artery Tibial	RP11-380L11.4	0.14	0.12	lasso	4	0.12	2.2e-09	6.667	6.6	4.9e-11	-0.04	0.02	0.98	TRUE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	5.260	6.4	1.9e-10	-0.23	0.02	0.81	TRUE
17	GTEx	Esophagus Mucosa	KDM2B	0.11	0.04	enet	22	0.10	4.1e-07	2.394	5.8	6.0e-09	-0.10	0.88	0.04	TRUE
38	NTR	Blood	CAMKK2	0.04	0.02	bslmm	425	0.02	6.1e-07	0.004	-5.2	1.6e-07	-0.08	0.93	0.04	TRUE
3	GTEx	Adipose Subcutaneous	RP11-380L11.3	0.09	0.03	lasso	3	0.03	1.4e-03	6.667	8.5	2.9e-17	-0.07	0.02	0.97	FALSE
2	GTEx	Adipose Subcutaneous	CCDC92	0.23	0.04	enet	27	0.16	6.9e-13	-4.838	8.3	1.1e-16	-0.09	0.10	0.90	FALSE
37	METSIM	Adipose	RP11-214K3.24	0.05	0.03	bslmm	444	0.02	2.7e-04	5.939	7.9	3.9e-15	-0.07	0.03	0.95	FALSE
31	GTEx	Thyroid	CCDC92	0.06	0.03	lasso	3	0.02	1.1e-02	6.656	7.8	6.0e-15	-0.08	0.03	0.95	FALSE
34	METSIM	Adipose	CCDC92	0.10	0.01	bslmm	435	0.06	5.5e-10	-3.120	7.7	1.1e-14	-0.08	0.18	0.82	FALSE
22	GTEx	Heart Atrial Appendage	RP11-380L11.4	0.18	0.11	lasso	7	0.12	6.5e-06	6.681	7.4	1.0e-13	-0.07	0.02	0.97	FALSE
23	GTEx	Heart Left Ventricle	CCDC92	0.26	0.19	lasso	4	0.21	1.9e-11	5.939	7.1	9.2e-13	-0.06	0.06	0.94	FALSE
27	GTEx	Nerve Tibial	CCDC92	0.16	0.01	enet	6	0.04	6.7e-04	5.567	6.9	6.0e-12	-0.10	0.08	0.62	FALSE
14	GTEx	Colon Sigmoid	RP11-380L11.4	0.21	0.12	lasso	3	0.08	1.1e-03	6.616	6.8	9.6e-12	-0.06	0.02	0.94	FALSE
42	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAH10	0.07	0.03	lasso	3	0.05	7.4e-06	6.718	6.7	1.7e-11	-0.06	0.02	0.98	FALSE
33	METSIM	Adipose	ABCB9	0.04	0.03	enet	19	0.03	7.7e-05	-5.277	-6.7	1.8e-11	0.38	0.08	0.65	FALSE
46	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF664	0.06	0.05	enet	9	0.05	2.8e-05	6.667	-6.7	2.5e-11	0.08	0.02	0.98	FALSE
20	GTEx	Esophagus Muscularis	RP11-380L11.4	0.27	0.29	lasso	8	0.27	1.0e-16	6.672	6.7	2.8e-11	-0.05	0.02	0.98	FALSE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNAH10	0.11	0.03	blup	99	0.05	8.2e-11	5.535	6.6	3.1e-11	-0.05	0.02	0.98	FALSE
25	GTEx	Lung	RP11-380L11.4	0.07	0.07	lasso	3	0.07	8.2e-06	6.706	6.5	6.2e-11	-0.06	0.02	0.98	FALSE
32	GTEx	Thyroid	ZNF664	0.13	0.06	lasso	11	0.08	6.7e-07	5.806	-6.5	1.0e-10	0.04	0.03	0.97	FALSE
7	GTEx	Artery Tibial	PITPNM2	0.11	0.05	lasso	4	0.04	2.7e-04	-5.787	6.4	1.9e-10	0.00	0.05	0.93	FALSE
35	METSIM	Adipose	DNAH10	0.03	0.00	bslmm	475	0.01	3.2e-03	6.809	6.3	2.3e-10	-0.01	0.03	0.85	FALSE
10	GTEx	Breast Mammary Tissue (Male)	CCDC92	0.06	-0.01	lasso	3	0.00	4.3e-01	5.881	6.3	2.8e-10	-0.07	0.04	0.14	FALSE
41	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC92	0.07	0.02	blup	52	0.04	1.8e-02	5.806	6.2	6.0e-10	-0.05	0.02	0.72	FALSE
21	GTEx	Heart Atrial Appendage	CCDC92	0.12	0.11	enet	9	0.11	1.1e-05	4.458	6.1	9.0e-10	-0.05	0.05	0.93	FALSE
30	GTEx	Skin Sun Exposed Lower leg	RP11-380L11.4	0.04	0.02	enet	15	0.02	1.9e-02	6.762	6.1	1.0e-09	-0.04	0.02	0.94	FALSE
18	GTEx	Esophagus Mucosa	CCDC92	0.11	0.02	lasso	4	0.02	1.9e-02	5.939	6.1	1.1e-09	-0.05	0.08	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	HIP1R	0.06	0.02	lasso	6	0.04	1.9e-05	-5.277	-6.0	1.7e-09	0.09	0.18	0.02	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	DNAH10	0.04	0.03	lasso	5	0.02	4.6e-03	5.567	6.0	1.8e-09	-0.05	0.02	0.83	FALSE
36	METSIM	Adipose	MORN3	0.06	0.02	lasso	10	0.04	8.7e-07	5.443	5.8	5.0e-09	-0.05	0.06	0.93	FALSE
11	GTEx	Breast Mammary Tissue (Female)	CCDC92	0.05	-0.01	enet	2	-0.01	6.2e-01	5.806	5.8	6.1e-09	-0.04	0.04	0.28	FALSE
26	GTEx	Muscle Skeletal	RP11-380L11.4	0.14	0.03	lasso	8	0.03	4.0e-04	6.667	5.6	2.2e-08	-0.04	0.02	0.98	FALSE
28	GTEx	Nerve Tibial	KNTC1	0.12	0.05	lasso	5	0.05	1.9e-04	-5.202	-5.5	3.4e-08	0.31	0.53	0.03	FALSE
12	GTEx	Breast Mammary Tissue (Female)	C12orf65	0.06	0.00	enet	13	-0.01	6.5e-01	-3.930	-5.4	5.3e-08	0.27	0.05	0.06	FALSE
40	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	5.322	5.4	5.3e-08	-0.17	0.02	0.92	FALSE
6	GTEx	Artery Aorta	MPHOSPH9	0.08	0.01	lasso	4	0.04	4.6e-03	5.938	-5.4	6.1e-08	-0.06	0.08	0.76	FALSE
43	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLXIP	0.18	0.14	lasso	4	0.13	5.1e-04	5.000	5.3	1.1e-07	-0.16	0.02	0.90	FALSE
15	GTEx	Colon Transverse	MLXIP	0.20	0.18	enet	23	0.14	5.8e-07	5.386	5.3	1.4e-07	-0.17	1.00	0.00	FALSE
9	GTEx	Brain Putamen basal ganglia	WDR66	0.25	0.01	enet	16	-0.01	5.6e-01	4.702	-5.2	2.3e-07	0.15	0.06	0.18	FALSE
29	GTEx	Prostate	CCDC92	0.31	0.10	enet	42	0.11	9.0e-04	5.806	5.1	2.8e-07	-0.08	0.04	0.82	FALSE