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chr2:23,453,834-26,088,769

Best TWAS P=1.1e-44 · Best GWAS P=4.46e-39 conditioned to 0.717

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	12.85	-14.0	1.1e-44	-0.89	0.00	1.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	7.73	-10.6	1.9e-26	-0.49	0.49	0.24	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	11.90	11.9	1.4e-32	0.87	0.07	0.92	FALSE
4	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	7.80	10.8	3.3e-27	0.82	0.04	0.90	FALSE
5	GTEx	Adipose Visceral Omentum	UBXN2A	0.10	0.08	enet	29	0.03	9.8e-03	4.66	5.4	7.4e-08	0.09	0.74	0.06	FALSE
6	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	-6.81	7.3	3.2e-13	0.41	0.98	0.00	FALSE
7	GTEx	Artery Coronary	DNAJC27	0.12	0.03	lasso	7	0.00	2.4e-01	2.88	5.3	1.4e-07	0.46	0.14	0.22	FALSE
8	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	11.05	12.4	1.9e-35	0.70	0.99	0.01	FALSE
9	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	11.05	10.9	8.1e-28	0.59	0.52	0.44	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	11.90	-10.5	1.2e-25	-0.84	0.02	0.97	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	11.90	-12.4	1.9e-35	-0.93	0.01	0.96	FALSE
12	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	2.40	5.7	9.7e-09	0.45	0.08	0.12	FALSE
13	GTEx	Esophagus Muscularis	ITSN2	0.10	0.04	lasso	7	0.09	6.1e-06	-0.55	5.1	2.8e-07	0.09	0.29	0.07	FALSE
14	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	11.05	-13.5	2.4e-41	-0.92	0.01	0.99	FALSE
15	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	11.05	-12.8	2.7e-37	-0.82	0.02	0.97	FALSE
16	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	11.57	11.6	5.7e-31	0.80	0.78	0.22	FALSE
17	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	12.41	13.3	4.1e-40	0.87	0.75	0.25	FALSE
18	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	11.57	13.5	1.4e-41	0.87	0.66	0.34	FALSE
19	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	-1.60	-7.2	4.6e-13	-0.37	0.06	0.08	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	12.41	-13.4	5.2e-41	-0.90	0.69	0.31	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	CENPO	0.08	0.04	enet	5	0.05	2.6e-07	-4.51	-5.9	3.7e-09	-0.36	1.00	0.00	FALSE
22	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	13.08	-7.2	4.6e-13	-0.63	0.00	1.00	FALSE
23	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	-8.80	-7.2	7.5e-13	-0.30	1.00	0.00	TRUE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	1.47	-6.7	2.8e-11	-0.51	0.54	0.42	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	-1.43	-6.0	1.6e-09	-0.20	0.97	0.03	FALSE
26	The Cancer Genome Atlas	Glioblastoma Multiforme	C2orf84	0.13	0.07	blup	56	0.05	1.5e-02	5.08	5.5	3.2e-08	0.10	0.02	0.18	TRUE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-1.43	-6.8	7.4e-12	-0.26	0.01	0.41	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	-10.23	-10.2	1.5e-24	-0.65	0.56	0.06	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	8.50	-11.7	1.9e-31	-0.88	0.03	0.94	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	2.87	-6.4	1.6e-10	-0.56	0.36	0.58	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-1.43	-6.9	3.8e-12	-0.21	0.38	0.62	FALSE
32	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	-8.80	-7.1	1.2e-12	-0.32	0.01	0.56	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-2.04	-5.9	3.9e-09	-0.11	0.01	0.29	FALSE
34	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-1.43	-6.8	1.1e-11	-0.23	0.92	0.06	FALSE