[Hub]/) : Traits : Leg fat percentage (right) :

chr2:23,453,834-26,088,769

Best TWAS P=1.1e-44 · Best GWAS P=4.46e-39 conditioned to 0.717

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADCY3 0.16 0.12 lasso 10 0.14 3.2e-17 12.85 -14.0 1.1e-44 -0.89 0.00 1.00 TRUE
2 CommonMind Brain Pre-frontal Cortex CENPO 0.07 0.03 bslmm 322 0.03 7.0e-05 7.73 -10.6 1.9e-26 -0.49 0.49 0.24 FALSE
3 GTEx Adipose Subcutaneous ADCY3 0.07 0.04 lasso 6 0.01 3.2e-02 11.90 11.9 1.4e-32 0.87 0.07 0.92 FALSE
4 GTEx Adipose Subcutaneous RP11-443B20.1 0.04 0.00 enet 10 0.00 1.2e-01 7.80 10.8 3.3e-27 0.82 0.04 0.90 FALSE
5 GTEx Adipose Visceral Omentum UBXN2A 0.10 0.08 enet 29 0.03 9.8e-03 4.66 5.4 7.4e-08 0.09 0.74 0.06 FALSE
6 GTEx Adrenal Gland PTRHD1 0.32 0.28 lasso 3 0.26 8.3e-10 -6.81 7.3 3.2e-13 0.41 0.98 0.00 FALSE
7 GTEx Artery Coronary DNAJC27 0.12 0.03 lasso 7 0.00 2.4e-01 2.88 5.3 1.4e-07 0.46 0.14 0.22 FALSE
8 GTEx Artery Tibial ADCY3 0.21 0.14 lasso 6 0.15 4.3e-12 11.05 12.4 1.9e-35 0.70 0.99 0.01 FALSE
9 GTEx Artery Tibial RP11-443B20.1 0.17 0.08 enet 40 0.09 8.2e-08 11.05 10.9 8.1e-28 0.59 0.52 0.44 FALSE
10 GTEx Cells EBV-transformed lymphocytes ADCY3 0.25 0.23 enet 10 0.12 9.2e-05 11.90 -10.5 1.2e-25 -0.84 0.02 0.97 FALSE
11 GTEx Cells EBV-transformed lymphocytes RP11-443B20.1 0.13 0.13 enet 9 0.05 9.2e-03 11.90 -12.4 1.9e-35 -0.93 0.01 0.96 FALSE
12 GTEx Esophagus Muscularis NCOA1 0.11 0.01 enet 9 0.01 5.8e-02 2.40 5.7 9.7e-09 0.45 0.08 0.12 FALSE
13 GTEx Esophagus Muscularis ITSN2 0.10 0.04 lasso 7 0.09 6.1e-06 -0.55 5.1 2.8e-07 0.09 0.29 0.07 FALSE
14 GTEx Nerve Tibial ADCY3 0.09 0.05 enet 6 0.03 2.2e-03 11.05 -13.5 2.4e-41 -0.92 0.01 0.99 FALSE
15 GTEx Nerve Tibial RP11-443B20.1 0.07 0.03 enet 6 0.02 1.1e-02 11.05 -12.8 2.7e-37 -0.82 0.02 0.97 FALSE
16 GTEx Whole Blood DNAJC27 0.08 0.10 lasso 1 0.10 2.2e-09 11.57 11.6 5.7e-31 0.80 0.78 0.22 FALSE
17 GTEx Whole Blood ADCY3 0.23 0.24 enet 24 0.27 5.5e-25 12.41 13.3 4.1e-40 0.87 0.75 0.25 FALSE
18 GTEx Whole Blood RP11-443B20.1 0.21 0.17 enet 32 0.20 1.8e-18 11.57 13.5 1.4e-41 0.87 0.66 0.34 FALSE
19 METSIM Adipose EFR3B 0.04 0.00 bslmm 357 0.00 9.7e-02 -1.60 -7.2 4.6e-13 -0.37 0.06 0.08 FALSE
20 ROSMAP Brain Pre-frontal Cortex ADCY3 0.17 0.26 enet 32 0.26 6.8e-33 12.41 -13.4 5.2e-41 -0.90 0.69 0.31 FALSE
21 ROSMAP Brain Pre-frontal Cortex CENPO 0.08 0.04 enet 5 0.05 2.6e-07 -4.51 -5.9 3.7e-09 -0.36 1.00 0.00 FALSE
22 YFS Blood ADCY3 0.07 0.02 bslmm 343 0.04 7.3e-14 13.08 -7.2 4.6e-13 -0.63 0.00 1.00 FALSE
23 YFS Blood POMC 0.35 0.05 enet 71 0.19 5.7e-59 -8.80 -7.2 7.5e-13 -0.30 1.00 0.00 TRUE
24 The Cancer Genome Atlas Breast Invasive Carcinoma ADCY3 0.05 0.03 blup 81 0.03 5.0e-07 1.47 -6.7 2.8e-11 -0.51 0.54 0.42 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma POMC 0.08 0.05 lasso 3 0.06 2.6e-12 -1.43 -6.0 1.6e-09 -0.20 0.97 0.03 FALSE
26 The Cancer Genome Atlas Glioblastoma Multiforme C2orf84 0.13 0.07 blup 56 0.05 1.5e-02 5.08 5.5 3.2e-08 0.10 0.02 0.18 TRUE
27 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma POMC 0.06 0.00 enet 12 0.03 9.3e-05 -1.43 -6.8 7.4e-12 -0.26 0.01 0.41 FALSE
28 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EFR3B 0.03 0.05 lasso 1 0.04 1.9e-05 -10.23 -10.2 1.5e-24 -0.65 0.56 0.06 FALSE
29 The Cancer Genome Atlas Brain Lower Grade Glioma ADCY3 0.03 0.02 blup 81 0.02 7.1e-04 8.50 -11.7 1.9e-31 -0.88 0.03 0.94 FALSE
30 The Cancer Genome Atlas Lung Adenocarcinoma DNAJC27 0.05 0.01 blup 46 0.04 3.2e-05 2.87 -6.4 1.6e-10 -0.56 0.36 0.58 FALSE
31 The Cancer Genome Atlas Lung Adenocarcinoma POMC 0.14 0.04 enet 7 0.08 5.3e-10 -1.43 -6.9 3.8e-12 -0.21 0.38 0.62 FALSE
32 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma POMC 0.19 0.01 blup 38 0.05 1.5e-04 -8.80 -7.1 1.2e-12 -0.32 0.01 0.56 FALSE
33 The Cancer Genome Atlas Pancreatic Adenocarcinoma POMC 0.22 0.05 blup 37 0.03 2.1e-02 -2.04 -5.9 3.9e-09 -0.11 0.01 0.29 FALSE
34 The Cancer Genome Atlas Prostate Adenocarcinoma POMC 0.11 0.08 enet 7 0.09 1.6e-09 -1.43 -6.8 1.1e-11 -0.23 0.92 0.06 FALSE