[Hub]/) : Traits : Trunk fat-free mass :

chr11:66,468,469-70,179,848

Best TWAS P=1.13e-37 · Best GWAS P=6.47e-37 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous IGHMBP2 0.42 0.44 lasso 16 0.45 3.2e-40 5.0 5.6 2.4e-08 0.06 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous RAD9A 0.43 0.22 lasso 6 0.23 7.1e-19 -12.7 -12.2 1.7e-34 0.97 0.00 1.00 FALSE
3 GTEx Adipose Visceral Omentum IGHMBP2 0.36 0.37 enet 23 0.39 9.8e-22 5.0 5.7 1.4e-08 0.06 1.00 0.00 FALSE
4 GTEx Adipose Visceral Omentum MRPL21 0.34 0.38 lasso 8 0.38 8.3e-21 5.0 -5.1 3.1e-07 -0.06 1.00 0.00 FALSE
5 GTEx Adrenal Gland MRPL21 0.38 0.34 lasso 6 0.31 6.8e-12 5.0 -5.3 1.4e-07 -0.07 1.00 0.00 FALSE
6 GTEx Artery Aorta IGHMBP2 0.32 0.32 lasso 5 0.36 5.1e-21 5.0 5.9 2.9e-09 0.05 1.00 0.00 FALSE
7 GTEx Artery Aorta ORAOV1 0.13 0.07 lasso 3 0.04 2.0e-03 6.1 5.5 4.8e-08 0.00 0.02 0.94 TRUE
8 GTEx Artery Aorta C11orf24 0.29 0.17 lasso 4 0.15 7.7e-09 -5.4 5.2 1.5e-07 -0.08 1.00 0.00 FALSE
9 GTEx Artery Tibial IGHMBP2 0.31 0.16 enet 24 0.25 3.0e-19 6.7 6.5 5.9e-11 0.05 1.00 0.00 FALSE
10 GTEx Artery Tibial C11orf24 0.13 0.08 lasso 3 0.06 1.5e-05 -5.7 6.1 8.5e-10 -0.08 0.84 0.01 TRUE
11 GTEx Artery Tibial RAD9A 0.39 0.26 lasso 2 0.24 3.5e-19 -12.7 -12.7 5.1e-37 1.00 0.00 1.00 FALSE
12 GTEx Brain Caudate basal ganglia IGHMBP2 0.31 0.25 lasso 5 0.30 2.0e-09 5.4 5.5 4.7e-08 0.04 0.75 0.01 FALSE
13 GTEx Brain Cerebellar Hemisphere IGHMBP2 0.23 0.22 lasso 3 0.16 8.4e-05 5.2 5.6 2.2e-08 0.02 0.20 0.06 FALSE
14 GTEx Brain Cerebellum MRGPRF 0.17 0.19 lasso 4 0.14 5.1e-05 -6.9 -6.8 7.8e-12 0.05 0.14 0.27 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia IGHMBP2 0.37 0.08 enet 46 0.12 5.6e-04 4.8 5.5 2.9e-08 0.06 0.26 0.07 TRUE
16 GTEx Breast Mammary Tissue IGHMBP2 0.49 0.47 enet 28 0.50 8.1e-29 5.0 6.3 2.5e-10 0.04 1.00 0.00 FALSE
17 GTEx Cells EBV-transformed lymphocytes IGHMBP2 0.54 0.62 enet 27 0.64 2.0e-26 4.9 5.5 3.0e-08 0.06 1.00 0.00 FALSE
18 GTEx Cells Transformed fibroblasts IGHMBP2 0.27 0.37 enet 10 0.37 5.0e-29 5.0 5.8 7.6e-09 0.05 1.00 0.00 FALSE
19 GTEx Cells Transformed fibroblasts RAD9A 0.24 0.16 lasso 3 0.16 3.6e-12 -12.7 -10.1 8.3e-24 0.92 0.00 1.00 FALSE
20 GTEx Colon Sigmoid C11orf24 0.46 0.17 enet 37 0.25 3.3e-09 -5.4 6.0 2.5e-09 -0.02 0.71 0.02 FALSE
21 GTEx Colon Transverse RAD9A 0.40 0.16 lasso 8 0.16 7.2e-08 -12.7 -9.2 3.3e-20 0.88 0.00 1.00 FALSE
22 GTEx Esophagus Mucosa IGHMBP2 0.37 0.47 enet 33 0.49 1.8e-36 5.0 5.2 2.3e-07 0.05 1.00 0.00 FALSE
23 GTEx Esophagus Muscularis TCIRG1 0.10 0.09 lasso 2 0.06 8.7e-05 -4.9 8.5 2.7e-17 -0.43 0.20 0.07 FALSE
24 GTEx Esophagus Muscularis IGHMBP2 0.12 0.06 enet 17 0.06 9.4e-05 5.0 8.0 1.3e-15 0.05 0.57 0.34 FALSE
25 GTEx Esophagus Muscularis C11orf24 0.10 0.10 lasso 1 0.08 1.5e-05 -5.7 5.7 1.3e-08 -0.08 0.82 0.01 FALSE
26 GTEx Esophagus Muscularis RAD9A 0.25 0.26 lasso 2 0.26 6.2e-16 -12.7 -12.8 1.1e-37 0.99 0.00 1.00 TRUE
27 GTEx Esophagus Muscularis MRGPRF 0.09 0.01 lasso 3 0.01 1.3e-01 -8.2 9.5 3.1e-21 0.02 0.02 0.85 FALSE
28 GTEx Heart Atrial Appendage IGHMBP2 0.26 0.27 lasso 4 0.26 3.9e-12 5.4 6.0 1.4e-09 0.03 1.00 0.00 FALSE
29 GTEx Heart Atrial Appendage C11orf24 0.23 0.18 lasso 8 0.16 8.7e-08 -5.7 5.2 2.5e-07 -0.08 0.95 0.00 FALSE
30 GTEx Heart Left Ventricle C11orf24 0.21 0.21 lasso 2 0.20 4.8e-11 -5.4 5.4 7.3e-08 -0.07 1.00 0.00 FALSE
31 GTEx Liver CDK2AP2 0.30 -0.01 lasso 7 -0.01 4.9e-01 -2.2 -5.8 5.0e-09 0.46 0.02 0.47 FALSE
32 GTEx Lung IGHMBP2 0.40 0.51 lasso 6 0.50 3.7e-44 5.0 5.2 2.5e-07 0.06 1.00 0.00 FALSE
33 GTEx Muscle Skeletal IGHMBP2 0.23 0.11 lasso 5 0.14 4.3e-14 5.0 5.5 3.1e-08 0.07 1.00 0.00 FALSE
34 GTEx Muscle Skeletal RAD9A 0.12 0.02 lasso 4 0.03 4.2e-04 -12.7 -8.5 1.7e-17 0.83 0.00 0.99 FALSE
35 GTEx Nerve Tibial IGHMBP2 0.45 0.47 enet 44 0.48 2.0e-38 5.0 6.2 6.2e-10 0.04 1.00 0.00 TRUE
36 GTEx Nerve Tibial C11orf24 0.67 0.65 enet 7 0.65 6.9e-60 -5.7 5.2 2.4e-07 -0.07 1.00 0.00 FALSE
37 GTEx Nerve Tibial RAD9A 0.53 0.24 lasso 10 0.23 5.6e-16 -12.7 -12.5 1.2e-35 0.99 0.00 1.00 FALSE
38 GTEx Nerve Tibial MRPL21 0.52 0.62 lasso 4 0.61 7.7e-54 5.0 -5.1 2.8e-07 -0.06 1.00 0.00 TRUE
39 GTEx Ovary MRPL21 0.38 0.36 lasso 3 0.29 7.5e-08 5.0 -5.2 2.3e-07 -0.05 0.83 0.01 FALSE
40 GTEx Pancreas MRPL21 0.13 0.17 lasso 6 0.17 1.2e-07 5.0 -5.2 1.9e-07 -0.06 0.95 0.00 FALSE
41 GTEx Skin Not Sun Exposed Suprapubic IGHMBP2 0.44 0.37 lasso 7 0.43 1.9e-25 5.0 5.7 9.4e-09 0.05 1.00 0.00 FALSE
42 GTEx Skin Sun Exposed Lower leg UNC93B1 0.11 0.03 lasso 2 0.04 6.4e-04 -2.3 6.3 3.0e-10 0.06 0.17 0.15 FALSE
43 GTEx Skin Sun Exposed Lower leg IGHMBP2 0.35 0.38 lasso 6 0.38 6.1e-33 5.0 5.6 1.8e-08 0.05 1.00 0.00 FALSE
44 GTEx Skin Sun Exposed Lower leg LRP5 0.13 0.05 lasso 5 0.07 1.2e-06 -5.9 -6.1 9.1e-10 0.14 0.79 0.01 FALSE
45 GTEx Stomach IGHMBP2 0.15 0.06 enet 14 0.03 9.1e-03 5.0 5.8 9.1e-09 0.07 0.72 0.02 FALSE
46 GTEx Testis RAD9A 0.72 0.50 lasso 4 0.49 1.1e-24 -12.7 -12.6 3.5e-36 1.00 0.00 1.00 FALSE
47 GTEx Thyroid CPT1A 0.05 0.02 lasso 3 0.01 3.3e-02 -5.0 5.4 8.0e-08 -0.01 0.35 0.19 FALSE
48 GTEx Thyroid IGHMBP2 0.32 0.40 enet 23 0.42 5.7e-35 5.0 5.9 3.3e-09 0.05 1.00 0.00 FALSE
49 GTEx Thyroid RAD9A 0.27 0.07 lasso 6 0.20 1.8e-15 -12.7 -6.2 7.4e-10 0.70 0.00 1.00 TRUE
50 GTEx Vagina C11orf24 0.24 0.04 lasso 9 0.08 5.8e-03 -1.6 6.5 8.5e-11 -0.19 0.08 0.11 FALSE
51 GTEx Whole Blood IGHMBP2 0.44 0.49 enet 16 0.51 1.3e-54 4.9 5.5 2.8e-08 0.05 1.00 0.00 FALSE
52 GTEx Whole Blood MRPL21 0.17 0.12 enet 21 0.12 2.5e-11 5.0 -5.2 2.5e-07 -0.05 1.00 0.00 TRUE
53 METSIM Adipose IGHMBP2 0.21 0.31 enet 28 0.33 3.8e-50 4.9 5.7 1.2e-08 0.04 1.00 0.00 FALSE
54 METSIM Adipose MTL5 0.07 0.04 bslmm 420 0.04 2.7e-06 5.3 6.3 2.4e-10 0.01 0.99 0.00 FALSE
55 NTR Blood IGHMBP2 0.02 0.02 lasso 7 0.02 5.9e-06 5.0 5.2 1.6e-07 0.06 0.99 0.00 FALSE
56 NTR Blood MRPL21 0.06 0.07 enet 19 0.07 7.0e-23 4.9 -6.0 2.3e-09 -0.03 1.00 0.00 FALSE
57 ROSMAP Brain Pre-frontal Cortex GAL 0.21 0.17 bslmm 393 0.17 1.5e-21 -6.8 -7.7 1.6e-14 -0.02 1.00 0.00 FALSE
58 ROSMAP Brain Pre-frontal Cortex PPP6R3 0.04 0.01 blup 421 0.02 3.2e-04 -9.4 10.1 6.9e-24 -0.03 0.13 0.86 FALSE
59 ROSMAP Brain Pre-frontal Cortex IGHMBP2 0.19 0.19 enet 17 0.20 3.9e-25 5.1 5.6 2.2e-08 0.07 1.00 0.00 FALSE
60 ROSMAP Brain Pre-frontal Cortex CDK2AP2 0.03 0.02 enet 11 0.03 1.6e-04 -2.4 6.2 4.1e-10 -0.48 0.27 0.60 FALSE
61 ROSMAP Brain Pre-frontal Cortex RAD9A 0.34 0.17 enet 21 0.20 1.1e-25 -12.7 -10.4 3.0e-25 0.89 0.00 1.00 FALSE
62 YFS Blood IGHMBP2 0.23 0.41 enet 31 0.42 1.2e-150 5.1 5.5 3.5e-08 0.06 1.00 0.00 FALSE
63 YFS Blood MRPL21 0.14 0.18 enet 38 0.19 3.6e-60 5.1 -5.3 1.3e-07 -0.05 1.00 0.00 FALSE
64 YFS Blood MTL5 0.05 0.03 blup 422 0.03 2.1e-11 -3.7 7.1 1.3e-12 -0.04 1.00 0.00 FALSE
65 YFS Blood RAD9A 0.08 0.02 lasso 7 0.04 5.4e-12 -12.7 -7.3 2.4e-13 0.78 0.00 1.00 FALSE
66 The Cancer Genome Atlas Bladder Urothelial Carcinoma MRPL21 0.07 0.06 blup 45 0.07 1.4e-06 5.0 -5.7 1.5e-08 -0.05 0.55 0.45 FALSE
67 The Cancer Genome Atlas Breast Invasive Carcinoma IGHMBP2 0.06 0.07 blup 60 0.08 1.6e-16 5.0 5.6 2.5e-08 0.07 0.05 0.95 TRUE
68 The Cancer Genome Atlas Breast Invasive Carcinoma MRPL21 0.10 0.17 blup 45 0.17 1.2e-33 5.1 -5.3 1.5e-07 -0.06 0.99 0.01 FALSE
69 The Cancer Genome Atlas Colon Adenocarcinoma MRPL21 0.23 0.30 blup 45 0.32 4.8e-19 5.0 -5.4 8.6e-08 -0.05 0.99 0.01 FALSE
70 The Cancer Genome Atlas Glioblastoma Multiforme IGHMBP2 0.35 0.16 blup 60 0.20 1.4e-06 4.8 5.9 3.7e-09 0.04 0.05 0.94 FALSE
71 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IGHMBP2 0.21 0.22 lasso 5 0.22 2.2e-24 5.1 5.3 9.7e-08 0.07 0.05 0.94 FALSE
72 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SAPS3 0.04 0.02 blup 84 0.04 2.5e-05 -7.8 10.4 1.6e-25 0.00 0.12 0.88 TRUE
73 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma IGHMBP2 0.27 0.30 blup 60 0.32 1.1e-18 4.9 5.1 2.7e-07 0.05 0.07 0.92 FALSE
74 The Cancer Genome Atlas Brain Lower Grade Glioma IGHMBP2 0.30 0.16 lasso 6 0.18 5.9e-20 4.8 5.8 8.1e-09 0.06 0.08 0.91 FALSE
75 The Cancer Genome Atlas Liver Hepatocellular Carcinoma IGHMBP2 0.15 0.03 blup 60 0.08 1.4e-04 5.7 5.5 5.0e-08 0.07 0.01 0.98 FALSE
76 The Cancer Genome Atlas Liver Hepatocellular Carcinoma MRPL21 0.11 0.07 enet 3 0.07 2.9e-04 5.1 -5.1 2.7e-07 -0.07 0.22 0.69 FALSE
77 The Cancer Genome Atlas Lung Adenocarcinoma IGHMBP2 0.11 0.14 blup 60 0.17 3.1e-19 4.9 5.5 2.8e-08 0.06 0.05 0.95 FALSE
78 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MRPL21 0.12 0.19 blup 45 0.20 8.2e-22 5.0 -5.2 1.9e-07 -0.06 0.99 0.01 FALSE
79 The Cancer Genome Atlas Pancreatic Adenocarcinoma IGHMBP2 0.18 0.18 lasso 4 0.19 1.9e-08 4.8 5.2 2.2e-07 0.06 0.05 0.95 FALSE
80 The Cancer Genome Atlas Pancreatic Adenocarcinoma MRPL21 0.43 0.39 enet 17 0.39 1.1e-17 5.0 -5.4 5.4e-08 -0.06 0.98 0.02 FALSE
81 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma IGHMBP2 0.24 0.18 blup 60 0.20 1.4e-08 -4.5 5.6 2.5e-08 0.06 0.29 0.64 FALSE
82 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma MTL5 0.09 0.01 blup 69 0.04 1.0e-02 -5.3 5.8 4.8e-09 -0.02 0.02 0.33 FALSE
83 The Cancer Genome Atlas Prostate Adenocarcinoma IGHMBP2 0.18 0.09 enet 10 0.17 1.2e-17 4.8 6.0 2.0e-09 0.04 0.07 0.93 FALSE
84 The Cancer Genome Atlas Rectum Adenocarcinoma IGHMBP2 0.30 0.20 enet 9 0.26 9.9e-07 5.3 5.8 6.9e-09 0.05 0.03 0.94 FALSE
85 The Cancer Genome Atlas Soft Tissue Sarcoma IGHMBP2 0.10 0.09 blup 60 0.09 4.1e-06 4.8 6.1 9.0e-10 0.04 0.03 0.96 TRUE
86 The Cancer Genome Atlas Stomach Adenocarcinoma IGHMBP2 0.06 0.06 lasso 4 0.06 7.5e-05 4.8 5.2 1.9e-07 0.04 0.02 0.97 FALSE
87 The Cancer Genome Atlas Testicular Germ Cell Tumors IGHMBP2 0.30 0.27 blup 60 0.22 2.8e-08 5.1 5.2 1.9e-07 0.05 0.06 0.94 FALSE
88 The Cancer Genome Atlas Testicular Germ Cell Tumors MRPL21 0.21 0.28 enet 14 0.26 7.6e-10 4.8 -5.1 3.0e-07 -0.07 0.98 0.02 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma CCND1 0.05 0.03 lasso 2 0.02 8.8e-03 -5.8 5.6 2.4e-08 0.00 0.02 0.13 TRUE
90 The Cancer Genome Atlas Thyroid Carcinoma IGHMBP2 0.20 0.20 blup 60 0.22 1.1e-20 5.1 5.5 3.1e-08 0.06 0.04 0.96 FALSE
91 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma MRPL21 0.19 0.10 lasso 3 0.14 1.2e-04 5.0 -5.4 5.2e-08 -0.06 0.12 0.74 FALSE