[Hub]/) : Traits : Trunk fat-free mass : ← →

chr11:66,468,469-70,179,848

Best TWAS P=1.13e-37 · Best GWAS P=6.47e-37 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	GTEx	Esophagus Muscularis	RAD9A	0.25	0.26	lasso	2	0.26	6.2e-16	-12.7	-12.8	1.1e-37	0.99	0.00	1.00	TRUE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAPS3	0.04	0.02	blup	84	0.04	2.5e-05	-7.8	10.4	1.6e-25	0.00	0.12	0.88	TRUE
35	GTEx	Nerve Tibial	IGHMBP2	0.45	0.47	enet	44	0.48	2.0e-38	5.0	6.2	6.2e-10	0.04	1.00	0.00	TRUE
49	GTEx	Thyroid	RAD9A	0.27	0.07	lasso	6	0.20	1.8e-15	-12.7	-6.2	7.4e-10	0.70	0.00	1.00	TRUE
10	GTEx	Artery Tibial	C11orf24	0.13	0.08	lasso	3	0.06	1.5e-05	-5.7	6.1	8.5e-10	-0.08	0.84	0.01	TRUE
85	The Cancer Genome Atlas	Soft Tissue Sarcoma	IGHMBP2	0.10	0.09	blup	60	0.09	4.1e-06	4.8	6.1	9.0e-10	0.04	0.03	0.96	TRUE
89	The Cancer Genome Atlas	Thyroid Carcinoma	CCND1	0.05	0.03	lasso	2	0.02	8.8e-03	-5.8	5.6	2.4e-08	0.00	0.02	0.13	TRUE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	IGHMBP2	0.06	0.07	blup	60	0.08	1.6e-16	5.0	5.6	2.5e-08	0.07	0.05	0.95	TRUE
15	GTEx	Brain Nucleus accumbens basal ganglia	IGHMBP2	0.37	0.08	enet	46	0.12	5.6e-04	4.8	5.5	2.9e-08	0.06	0.26	0.07	TRUE
7	GTEx	Artery Aorta	ORAOV1	0.13	0.07	lasso	3	0.04	2.0e-03	6.1	5.5	4.8e-08	0.00	0.02	0.94	TRUE
52	GTEx	Whole Blood	MRPL21	0.17	0.12	enet	21	0.12	2.5e-11	5.0	-5.2	2.5e-07	-0.05	1.00	0.00	TRUE
38	GTEx	Nerve Tibial	MRPL21	0.52	0.62	lasso	4	0.61	7.7e-54	5.0	-5.1	2.8e-07	-0.06	1.00	0.00	TRUE
11	GTEx	Artery Tibial	RAD9A	0.39	0.26	lasso	2	0.24	3.5e-19	-12.7	-12.7	5.1e-37	1.00	0.00	1.00	FALSE
46	GTEx	Testis	RAD9A	0.72	0.50	lasso	4	0.49	1.1e-24	-12.7	-12.6	3.5e-36	1.00	0.00	1.00	FALSE
37	GTEx	Nerve Tibial	RAD9A	0.53	0.24	lasso	10	0.23	5.6e-16	-12.7	-12.5	1.2e-35	0.99	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RAD9A	0.43	0.22	lasso	6	0.23	7.1e-19	-12.7	-12.2	1.7e-34	0.97	0.00	1.00	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	RAD9A	0.34	0.17	enet	21	0.20	1.1e-25	-12.7	-10.4	3.0e-25	0.89	0.00	1.00	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	PPP6R3	0.04	0.01	blup	421	0.02	3.2e-04	-9.4	10.1	6.9e-24	-0.03	0.13	0.86	FALSE
19	GTEx	Cells Transformed fibroblasts	RAD9A	0.24	0.16	lasso	3	0.16	3.6e-12	-12.7	-10.1	8.3e-24	0.92	0.00	1.00	FALSE
27	GTEx	Esophagus Muscularis	MRGPRF	0.09	0.01	lasso	3	0.01	1.3e-01	-8.2	9.5	3.1e-21	0.02	0.02	0.85	FALSE
21	GTEx	Colon Transverse	RAD9A	0.40	0.16	lasso	8	0.16	7.2e-08	-12.7	-9.2	3.3e-20	0.88	0.00	1.00	FALSE
34	GTEx	Muscle Skeletal	RAD9A	0.12	0.02	lasso	4	0.03	4.2e-04	-12.7	-8.5	1.7e-17	0.83	0.00	0.99	FALSE
23	GTEx	Esophagus Muscularis	TCIRG1	0.10	0.09	lasso	2	0.06	8.7e-05	-4.9	8.5	2.7e-17	-0.43	0.20	0.07	FALSE
24	GTEx	Esophagus Muscularis	IGHMBP2	0.12	0.06	enet	17	0.06	9.4e-05	5.0	8.0	1.3e-15	0.05	0.57	0.34	FALSE
57	ROSMAP	Brain Pre-frontal Cortex	GAL	0.21	0.17	bslmm	393	0.17	1.5e-21	-6.8	-7.7	1.6e-14	-0.02	1.00	0.00	FALSE
65	YFS	Blood	RAD9A	0.08	0.02	lasso	7	0.04	5.4e-12	-12.7	-7.3	2.4e-13	0.78	0.00	1.00	FALSE
64	YFS	Blood	MTL5	0.05	0.03	blup	422	0.03	2.1e-11	-3.7	7.1	1.3e-12	-0.04	1.00	0.00	FALSE
14	GTEx	Brain Cerebellum	MRGPRF	0.17	0.19	lasso	4	0.14	5.1e-05	-6.9	-6.8	7.8e-12	0.05	0.14	0.27	FALSE
9	GTEx	Artery Tibial	IGHMBP2	0.31	0.16	enet	24	0.25	3.0e-19	6.7	6.5	5.9e-11	0.05	1.00	0.00	FALSE
50	GTEx	Vagina	C11orf24	0.24	0.04	lasso	9	0.08	5.8e-03	-1.6	6.5	8.5e-11	-0.19	0.08	0.11	FALSE
54	METSIM	Adipose	MTL5	0.07	0.04	bslmm	420	0.04	2.7e-06	5.3	6.3	2.4e-10	0.01	0.99	0.00	FALSE
16	GTEx	Breast Mammary Tissue	IGHMBP2	0.49	0.47	enet	28	0.50	8.1e-29	5.0	6.3	2.5e-10	0.04	1.00	0.00	FALSE
42	GTEx	Skin Sun Exposed Lower leg	UNC93B1	0.11	0.03	lasso	2	0.04	6.4e-04	-2.3	6.3	3.0e-10	0.06	0.17	0.15	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	CDK2AP2	0.03	0.02	enet	11	0.03	1.6e-04	-2.4	6.2	4.1e-10	-0.48	0.27	0.60	FALSE
44	GTEx	Skin Sun Exposed Lower leg	LRP5	0.13	0.05	lasso	5	0.07	1.2e-06	-5.9	-6.1	9.1e-10	0.14	0.79	0.01	FALSE
28	GTEx	Heart Atrial Appendage	IGHMBP2	0.26	0.27	lasso	4	0.26	3.9e-12	5.4	6.0	1.4e-09	0.03	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	IGHMBP2	0.18	0.09	enet	10	0.17	1.2e-17	4.8	6.0	2.0e-09	0.04	0.07	0.93	FALSE
56	NTR	Blood	MRPL21	0.06	0.07	enet	19	0.07	7.0e-23	4.9	-6.0	2.3e-09	-0.03	1.00	0.00	FALSE
20	GTEx	Colon Sigmoid	C11orf24	0.46	0.17	enet	37	0.25	3.3e-09	-5.4	6.0	2.5e-09	-0.02	0.71	0.02	FALSE
6	GTEx	Artery Aorta	IGHMBP2	0.32	0.32	lasso	5	0.36	5.1e-21	5.0	5.9	2.9e-09	0.05	1.00	0.00	FALSE
48	GTEx	Thyroid	IGHMBP2	0.32	0.40	enet	23	0.42	5.7e-35	5.0	5.9	3.3e-09	0.05	1.00	0.00	FALSE
70	The Cancer Genome Atlas	Glioblastoma Multiforme	IGHMBP2	0.35	0.16	blup	60	0.20	1.4e-06	4.8	5.9	3.7e-09	0.04	0.05	0.94	FALSE
82	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MTL5	0.09	0.01	blup	69	0.04	1.0e-02	-5.3	5.8	4.8e-09	-0.02	0.02	0.33	FALSE
31	GTEx	Liver	CDK2AP2	0.30	-0.01	lasso	7	-0.01	4.9e-01	-2.2	-5.8	5.0e-09	0.46	0.02	0.47	FALSE
84	The Cancer Genome Atlas	Rectum Adenocarcinoma	IGHMBP2	0.30	0.20	enet	9	0.26	9.9e-07	5.3	5.8	6.9e-09	0.05	0.03	0.94	FALSE
18	GTEx	Cells Transformed fibroblasts	IGHMBP2	0.27	0.37	enet	10	0.37	5.0e-29	5.0	5.8	7.6e-09	0.05	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	IGHMBP2	0.30	0.16	lasso	6	0.18	5.9e-20	4.8	5.8	8.1e-09	0.06	0.08	0.91	FALSE
45	GTEx	Stomach	IGHMBP2	0.15	0.06	enet	14	0.03	9.1e-03	5.0	5.8	9.1e-09	0.07	0.72	0.02	FALSE
41	GTEx	Skin Not Sun Exposed Suprapubic	IGHMBP2	0.44	0.37	lasso	7	0.43	1.9e-25	5.0	5.7	9.4e-09	0.05	1.00	0.00	FALSE
53	METSIM	Adipose	IGHMBP2	0.21	0.31	enet	28	0.33	3.8e-50	4.9	5.7	1.2e-08	0.04	1.00	0.00	FALSE
25	GTEx	Esophagus Muscularis	C11orf24	0.10	0.10	lasso	1	0.08	1.5e-05	-5.7	5.7	1.3e-08	-0.08	0.82	0.01	FALSE
3	GTEx	Adipose Visceral Omentum	IGHMBP2	0.36	0.37	enet	23	0.39	9.8e-22	5.0	5.7	1.4e-08	0.06	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MRPL21	0.07	0.06	blup	45	0.07	1.4e-06	5.0	-5.7	1.5e-08	-0.05	0.55	0.45	FALSE
43	GTEx	Skin Sun Exposed Lower leg	IGHMBP2	0.35	0.38	lasso	6	0.38	6.1e-33	5.0	5.6	1.8e-08	0.05	1.00	0.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	IGHMBP2	0.23	0.22	lasso	3	0.16	8.4e-05	5.2	5.6	2.2e-08	0.02	0.20	0.06	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	IGHMBP2	0.19	0.19	enet	17	0.20	3.9e-25	5.1	5.6	2.2e-08	0.07	1.00	0.00	FALSE
1	GTEx	Adipose Subcutaneous	IGHMBP2	0.42	0.44	lasso	16	0.45	3.2e-40	5.0	5.6	2.4e-08	0.06	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	IGHMBP2	0.24	0.18	blup	60	0.20	1.4e-08	-4.5	5.6	2.5e-08	0.06	0.29	0.64	FALSE
51	GTEx	Whole Blood	IGHMBP2	0.44	0.49	enet	16	0.51	1.3e-54	4.9	5.5	2.8e-08	0.05	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Lung Adenocarcinoma	IGHMBP2	0.11	0.14	blup	60	0.17	3.1e-19	4.9	5.5	2.8e-08	0.06	0.05	0.95	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	IGHMBP2	0.54	0.62	enet	27	0.64	2.0e-26	4.9	5.5	3.0e-08	0.06	1.00	0.00	FALSE
33	GTEx	Muscle Skeletal	IGHMBP2	0.23	0.11	lasso	5	0.14	4.3e-14	5.0	5.5	3.1e-08	0.07	1.00	0.00	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	IGHMBP2	0.20	0.20	blup	60	0.22	1.1e-20	5.1	5.5	3.1e-08	0.06	0.04	0.96	FALSE
62	YFS	Blood	IGHMBP2	0.23	0.41	enet	31	0.42	1.2e-150	5.1	5.5	3.5e-08	0.06	1.00	0.00	FALSE
12	GTEx	Brain Caudate basal ganglia	IGHMBP2	0.31	0.25	lasso	5	0.30	2.0e-09	5.4	5.5	4.7e-08	0.04	0.75	0.01	FALSE
75	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IGHMBP2	0.15	0.03	blup	60	0.08	1.4e-04	5.7	5.5	5.0e-08	0.07	0.01	0.98	FALSE
91	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	MRPL21	0.19	0.10	lasso	3	0.14	1.2e-04	5.0	-5.4	5.2e-08	-0.06	0.12	0.74	FALSE
80	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MRPL21	0.43	0.39	enet	17	0.39	1.1e-17	5.0	-5.4	5.4e-08	-0.06	0.98	0.02	FALSE
30	GTEx	Heart Left Ventricle	C11orf24	0.21	0.21	lasso	2	0.20	4.8e-11	-5.4	5.4	7.3e-08	-0.07	1.00	0.00	FALSE
47	GTEx	Thyroid	CPT1A	0.05	0.02	lasso	3	0.01	3.3e-02	-5.0	5.4	8.0e-08	-0.01	0.35	0.19	FALSE
69	The Cancer Genome Atlas	Colon Adenocarcinoma	MRPL21	0.23	0.30	blup	45	0.32	4.8e-19	5.0	-5.4	8.6e-08	-0.05	0.99	0.01	FALSE
71	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IGHMBP2	0.21	0.22	lasso	5	0.22	2.2e-24	5.1	5.3	9.7e-08	0.07	0.05	0.94	FALSE
63	YFS	Blood	MRPL21	0.14	0.18	enet	38	0.19	3.6e-60	5.1	-5.3	1.3e-07	-0.05	1.00	0.00	FALSE
5	GTEx	Adrenal Gland	MRPL21	0.38	0.34	lasso	6	0.31	6.8e-12	5.0	-5.3	1.4e-07	-0.07	1.00	0.00	FALSE
8	GTEx	Artery Aorta	C11orf24	0.29	0.17	lasso	4	0.15	7.7e-09	-5.4	5.2	1.5e-07	-0.08	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	MRPL21	0.10	0.17	blup	45	0.17	1.2e-33	5.1	-5.3	1.5e-07	-0.06	0.99	0.01	FALSE
55	NTR	Blood	IGHMBP2	0.02	0.02	lasso	7	0.02	5.9e-06	5.0	5.2	1.6e-07	0.06	0.99	0.00	FALSE
40	GTEx	Pancreas	MRPL21	0.13	0.17	lasso	6	0.17	1.2e-07	5.0	-5.2	1.9e-07	-0.06	0.95	0.00	FALSE
78	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MRPL21	0.12	0.19	blup	45	0.20	8.2e-22	5.0	-5.2	1.9e-07	-0.06	0.99	0.01	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	IGHMBP2	0.06	0.06	lasso	4	0.06	7.5e-05	4.8	5.2	1.9e-07	0.04	0.02	0.97	FALSE
87	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IGHMBP2	0.30	0.27	blup	60	0.22	2.8e-08	5.1	5.2	1.9e-07	0.05	0.06	0.94	FALSE
79	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IGHMBP2	0.18	0.18	lasso	4	0.19	1.9e-08	4.8	5.2	2.2e-07	0.06	0.05	0.95	FALSE
22	GTEx	Esophagus Mucosa	IGHMBP2	0.37	0.47	enet	33	0.49	1.8e-36	5.0	5.2	2.3e-07	0.05	1.00	0.00	FALSE
39	GTEx	Ovary	MRPL21	0.38	0.36	lasso	3	0.29	7.5e-08	5.0	-5.2	2.3e-07	-0.05	0.83	0.01	FALSE
36	GTEx	Nerve Tibial	C11orf24	0.67	0.65	enet	7	0.65	6.9e-60	-5.7	5.2	2.4e-07	-0.07	1.00	0.00	FALSE
29	GTEx	Heart Atrial Appendage	C11orf24	0.23	0.18	lasso	8	0.16	8.7e-08	-5.7	5.2	2.5e-07	-0.08	0.95	0.00	FALSE
32	GTEx	Lung	IGHMBP2	0.40	0.51	lasso	6	0.50	3.7e-44	5.0	5.2	2.5e-07	0.06	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IGHMBP2	0.27	0.30	blup	60	0.32	1.1e-18	4.9	5.1	2.7e-07	0.05	0.07	0.92	FALSE
76	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MRPL21	0.11	0.07	enet	3	0.07	2.9e-04	5.1	-5.1	2.7e-07	-0.07	0.22	0.69	FALSE
88	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MRPL21	0.21	0.28	enet	14	0.26	7.6e-10	4.8	-5.1	3.0e-07	-0.07	0.98	0.02	FALSE
4	GTEx	Adipose Visceral Omentum	MRPL21	0.34	0.38	lasso	8	0.38	8.3e-21	5.0	-5.1	3.1e-07	-0.06	1.00	0.00	FALSE