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chr17:6,518,588-8,765,412

Best TWAS P=3.27e-21 · Best GWAS P=6.41e-21 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
15	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	9.28	9.4	3.3e-21	0.29	0.01	0.99	TRUE
55	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	4.90	7.9	2.3e-15	0.20	0.12	0.73	TRUE
39	The Cancer Genome Atlas	Glioblastoma Multiforme	AMAC1L3	0.14	0.12	lasso	3	0.12	1.8e-04	7.58	-7.8	9.1e-15	-0.25	0.01	0.85	TRUE
16	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	7.65	7.6	2.8e-14	0.26	0.93	0.03	TRUE
10	GTEx	Breast Mammary Tissue (Male)	CHRNB1	0.28	-0.01	lasso	6	0.02	9.6e-02	9.28	7.4	1.5e-13	0.20	0.02	0.66	TRUE
28	GTEx	Whole Blood	TNFSF12	0.09	0.03	enet	24	0.04	1.9e-04	-5.44	-7.0	3.1e-12	-0.43	0.49	0.35	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EIF5A	0.20	0.12	bslmm	446	0.10	1.2e-12	-4.07	-6.6	3.1e-11	-0.05	1.00	0.00	TRUE
20	GTEx	Lung	CHRNB1	0.22	0.05	enet	17	0.14	7.5e-11	-2.22	6.3	3.5e-10	0.24	0.29	0.70	TRUE
35	YFS	Blood	TMEM107	0.17	0.17	lasso	5	0.19	2.0e-61	-5.95	-6.1	9.2e-10	-0.08	0.49	0.51	TRUE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EFNB3	0.07	0.04	blup	34	0.04	4.0e-05	-6.05	6.0	1.8e-09	0.34	0.16	0.07	TRUE
31	METSIM	Adipose	NEURL4	0.06	0.00	blup	454	0.01	8.2e-03	-0.63	-5.7	9.8e-09	-0.02	0.11	0.02	TRUE
14	GTEx	Esophagus Mucosa	SOX15	0.16	0.03	enet	9	0.07	2.3e-05	9.38	-5.3	1.4e-07	-0.74	0.01	0.97	TRUE
5	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	9.28	9.3	1.1e-20	0.27	0.01	0.99	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	9.28	9.2	2.1e-20	0.29	0.02	0.98	FALSE
34	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	9.30	9.1	1.4e-19	0.31	0.01	0.99	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	9.28	8.8	1.9e-18	0.30	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	7.76	8.6	7.9e-18	0.23	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	9.30	8.5	2.0e-17	0.32	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	4.25	8.4	3.1e-17	0.34	0.00	0.76	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	9.28	8.4	6.4e-17	0.30	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	9.28	8.4	6.5e-17	0.34	0.00	0.87	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	-5.40	-8.3	8.0e-17	-0.45	0.01	0.66	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CHRNB1	0.09	0.06	lasso	2	0.08	9.8e-10	9.28	8.3	1.4e-16	0.16	0.01	0.99	FALSE
56	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	-4.51	-8.2	1.9e-16	-0.46	0.04	0.08	FALSE
11	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	9.28	8.1	6.9e-16	0.46	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	9.30	7.9	2.9e-15	0.36	0.00	0.99	FALSE
27	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	9.28	7.9	3.6e-15	0.15	0.01	0.99	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	7.53	7.7	1.1e-14	0.18	1.00	0.00	FALSE
25	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	7.75	7.7	1.4e-14	0.22	0.74	0.26	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	-4.01	7.7	1.9e-14	0.23	0.10	0.77	FALSE
18	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	7.65	7.6	2.8e-14	0.26	0.28	0.26	FALSE
9	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	7.36	7.4	1.8e-13	0.52	0.33	0.58	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	5.56	6.9	4.6e-12	0.28	0.53	0.47	FALSE
6	GTEx	Artery Aorta	CHRNB1	0.23	0.10	enet	7	0.13	1.3e-07	-3.50	6.6	3.4e-11	0.09	0.07	0.92	FALSE
8	GTEx	Artery Tibial	CHRNB1	0.27	0.20	lasso	5	0.22	8.1e-17	-3.52	6.4	2.0e-10	0.08	0.82	0.18	FALSE
22	GTEx	Pancreas	TRAPPC1	0.17	0.00	lasso	6	0.01	1.5e-01	7.65	6.2	4.8e-10	0.19	0.08	0.30	FALSE
4	GTEx	Adipose Subcutaneous	CHRNB1	0.30	0.22	lasso	8	0.26	1.6e-21	-3.56	6.1	8.2e-10	0.06	1.00	0.00	FALSE
17	GTEx	Esophagus Muscularis	CHRNB1	0.35	0.19	lasso	7	0.28	1.9e-17	-3.50	6.1	9.4e-10	0.06	0.96	0.04	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFSF12-TNFSF13	0.07	0.01	enet	17	0.03	4.4e-04	-5.40	-6.0	1.7e-09	-0.08	0.03	0.08	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALOXE3	0.04	0.00	blup	77	0.01	3.4e-02	-5.86	-6.0	2.6e-09	0.00	0.01	0.61	FALSE
13	GTEx	Colon Sigmoid	CHRNB1	0.18	0.06	enet	18	0.11	1.3e-04	-3.52	5.8	8.9e-09	0.17	0.24	0.47	FALSE
23	GTEx	Prostate	RP11-104H15.8	0.54	0.01	enet	1	0.06	1.6e-02	-5.66	-5.7	1.5e-08	-0.17	0.07	0.09	FALSE
7	GTEx	Artery Coronary	CHRNB1	0.26	0.08	enet	24	0.11	1.3e-04	7.53	5.6	1.7e-08	0.04	0.05	0.80	FALSE
21	GTEx	Muscle Skeletal	EIF5A	0.14	0.06	enet	35	0.05	4.2e-06	-3.65	-5.5	3.1e-08	-0.02	0.96	0.00	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHRNB1	0.04	0.03	blup	57	0.02	1.5e-03	-4.46	5.5	4.0e-08	0.34	0.06	0.29	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	TNFSF12-TNFSF13	0.07	0.05	lasso	3	0.02	1.9e-02	-5.33	-5.4	5.4e-08	-0.22	0.08	0.04	FALSE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	EFNB3	0.06	0.03	lasso	4	0.05	1.0e-05	-6.05	5.4	5.4e-08	0.19	0.91	0.00	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TNFSF12-TNFSF13	0.06	0.00	blup	58	0.01	3.4e-02	3.44	-5.4	6.7e-08	0.05	0.01	0.06	FALSE
41	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf68	0.05	0.00	blup	59	0.03	3.3e-04	-5.58	-5.4	7.8e-08	-0.08	0.00	0.94	FALSE
19	GTEx	Heart Left Ventricle	CHRNB1	0.16	0.03	lasso	4	0.05	9.6e-04	-4.01	5.4	8.2e-08	0.23	0.10	0.28	FALSE
26	GTEx	Small Intestine Terminal Ileum	CHRNB1	0.43	-0.01	lasso	9	0.00	2.9e-01	0.82	5.3	1.3e-07	-0.03	0.05	0.15	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	FGF11	0.08	0.04	blup	454	0.04	1.2e-05	-4.01	5.3	1.4e-07	0.31	0.98	0.01	FALSE
12	GTEx	Cells Transformed fibroblasts	TNFSF12	0.25	0.22	lasso	8	0.20	7.4e-15	-5.40	-5.2	1.5e-07	-0.30	1.00	0.00	FALSE
29	METSIM	Adipose	CNTROB	0.06	0.02	blup	497	0.03	1.3e-05	1.06	-5.2	2.2e-07	-0.08	0.89	0.00	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFSF12	0.05	0.00	blup	56	0.01	1.2e-02	-4.88	-5.2	2.3e-07	0.00	0.14	0.05	FALSE
30	METSIM	Adipose	FGF11	0.07	0.00	bslmm	477	0.02	1.5e-04	7.75	-5.2	2.6e-07	-0.26	0.73	0.05	FALSE