Hub : Genes

MVP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.1800	0.0880	2.0e-04	0.078	NA	0.058	NA	0.051	8.2e-05	NA	6.0e-04	NA	1.3e-03
2	GTEx	Breast Mammary Tissue (Male)	0.1359	0.0952	4.6e-02	-0.013	NA	0.053	NA	-0.009	9.9e-01	NA	2.4e-02	NA	6.1e-01
3	GTEx	Breast Mammary Tissue (Female)	0.0375	0.0383	1.5e-01	0.007	NA	0.039	NA	-0.010	2.0e-01	NA	2.5e-02	NA	8.8e-01
4	GTEx	Cells Transformed fibroblasts	0.1070	0.0470	1.9e-04	0.088	NA	0.091	NA	0.084	4.2e-07	NA	2.5e-07	NA	7.2e-07
5	GTEx	Nerve Tibial	0.0719	0.0351	4.3e-03	0.017	NA	0.004	NA	0.014	2.0e-02	NA	1.4e-01	NA	3.3e-02
6	YFS	Blood	0.0527	0.0195	2.0e-08	0.016	0.028	0.029	0.03	0.027	3.8e-06	1.0e-09	6.8e-10	4.3e-10	2.1e-09
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0174	0.0122	9.0e-03	0.015	0.007	0.000	NA	0.004	7.6e-03	5.5e-02	3.3e-01	NA	9.9e-02
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0609	0.0326	3.1e-03	0.039	0.016	0.026	NA	0.029	3.1e-05	5.9e-03	5.9e-04	NA	2.6e-04
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.1420	0.0730	1.5e-06	0.077	0.094	0.057	NA	0.078	6.9e-06	6.7e-07	9.8e-05	NA	5.9e-06
10	TCGA	Pancreatic Adenocarcinoma	0.1060	0.0610	3.9e-03	0.034	0.066	0.021	NA	0.042	1.4e-02	9.4e-04	4.2e-02	NA	7.5e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	2.0	3.2	5.1	-2.1	-1.5	-1.9	1.9	-1.9	1.5	1.8	0.0	2.3	1.8
Bipolar Disorder or Schizophrenia	2.5	6.1	12.6	-3.5	-2.4	-2.8	2.6	-2.7	0.8	2.8	0.0	2.9	2.1
Depressed Affect (Nagel 2018)	0.4	0.8	5.2	0.6	2.3	-0.6	-0.5	0.2	0.3	0.6	-1.1	0.4	0.5
Depression (Nagel 2018)	0.1	0.1	0.6	-0.0	0.4	-0.1	-0.3	0.2	0.7	0.1	0.0	0.1	-0.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.3	0.6	1.0	1.5	-0.7	1.1	0.1	-1.5	-0.2	-1.1	-1.1
Neuroticism (Nagel 2018)	0.5	1.2	2.3	-1.1	1.3	-1.4	0.8	-1.1	-1.0	1.5	-0.2	1.2	1.0
Schizophrenia (2018)	1.8	3.7	10.7	-3.3	-2.3	-2.1	1.9	-1.9	-0.5	2.1	0.0	1.9	1.3
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	0.6	1.0	1.0	-0.8	0.9	-0.5	-1.0	0.0	-1.3	-1.0
Worry (Nagel 2018)	2.2	4.7	10.5	-3.2	-0.2	-2.6	2.2	-2.3	-1.9	2.6	1.2	2.1	1.8
Alzheimer’s Disease (in mother)	2.6	3.0	8.0	-2.8	-2.0	-1.3	1.5	-1.8	-2.0	1.2	2.1	0.8	0.6
Alzheimer’s Disease (in father)	0.6	0.6	2.2	-0.7	1.5	-0.9	0.0	0.1	-0.6	0.4	-0.6	0.8	1.2
Alzheimer’s Disease (including proxy)	2.4	3.5	10.2	-3.2	-1.0	-1.9	1.9	-2.0	-2.2	1.5	1.5	1.5	1.3
Crohns Disease (2017)	0.2	0.5	1.7	-0.8	-1.3	-0.7	0.3	-0.5	0.2	0.8	0.8	0.7	0.4
Irritable Bowel Disease (IBD)	0.2	0.4	2.9	0.4	0.3	-0.2	-0.1	-0.3	1.7	0.3	0.2	0.5	0.2
Ulcerative Colitis (UC)	0.8	1.5	7.4	1.5	2.0	0.4	-0.7	0.3	2.7	-0.5	-0.6	0.1	-0.1
Major Depression (MDD)	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0	0.4	0.0	0.0	0.0	0.0
Reaction Time	0.8	1.5	4.2	-0.0	1.3	1.4	-1.1	1.1	0.5	-0.8	-0.1	-2.0	-1.9
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.7	1.1	1.3	1.3	-0.3	0.5	0.6	-1.2	-0.4	-0.6	-0.8
Breast Cancer	0.1	0.2	1.1	-0.5	0.3	-0.4	-0.3	0.3	-1.1	0.4	-0.2	0.2	0.4
Ovarian Cancer	0.3	0.4	1.9	-1.0	0.3	-0.5	0.5	-0.2	-0.1	0.3	-1.4	0.3	0.7
Prostate Cancer	0.5	0.7	1.3	0.9	0.5	1.1	-0.9	1.1	-0.7	-1.1	-0.4	-0.8	-0.7
Age at First Birth	0.3	0.5	1.3	0.5	0.2	0.8	-0.7	1.0	1.1	-1.0	0.0	-0.6	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.3	1.8	3.4	1.8	1.4	1.1	-1.7	1.5	1.4	-0.8	0.0	-1.6	-1.3
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.6	1.0	2.4	-1.2	-1.5	-1.1	0.7	-0.7	0.9	1.1	0.0	1.1	0.9
Mean Putamen Volume	0.2	0.2	0.8	0.6	0.9	-0.0	-0.1	0.4	-0.7	-0.3	-0.6	0.1	0.2
Fasting Glucose	0.5	0.6	1.4	-1.1	0.0	-0.8	1.0	-1.0	-1.0	1.2	0.0	0.4	0.2
HbA1C	0.4	0.5	2.3	-1.0	-0.6	-0.1	0.5	-0.2	-1.5	0.0	0.0	0.4	0.7
HDL Cholesterol	0.7	1.1	2.0	-1.4	-0.9	-1.2	1.4	-1.3	-0.3	1.1	0.0	1.2	1.0
LDL Cholesterol	0.2	0.4	1.7	-0.8	-0.1	0.1	0.4	-0.5	-0.2	0.4	0.0	-0.8	-1.3
Lupus	0.5	0.8	3.0	-0.1	-0.6	-0.5	1.5	-1.7	0.4	0.6	0.1	0.8	0.7
Neuroticism (2016)	0.7	0.9	2.0	-1.4	-0.9	-0.1	-1.0	1.0	1.2	0.4	0.8	-0.9	-1.2
Primary Biliary Cirrhosis	0.4	0.6	2.9	1.0	1.3	-0.2	-0.4	0.0	1.7	0.2	-0.7	0.2	0.1
Rheumatoid Arthritis	0.6	0.8	2.8	0.9	1.4	0.5	-1.7	1.3	-0.8	-0.6	-0.1	-0.3	-0.2
Schizophrenia (2014)	2.0	4.5	10.4	-3.2	-1.8	-2.2	2.1	-2.2	-0.1	2.2	0.0	2.7	2.3
Triglycerides	0.2	0.3	1.1	0.1	-0.0	-0.1	-0.4	0.2	-0.6	0.7	0.0	-0.7	-1.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.8	1.2	6.0	1.3	1.9	0.3	-0.3	0.0	2.4	-0.1	0.0	-0.0	0.1
Blood Eosinophil Count	1.1	8.2	41.3	-4.1	-3.4	-1.0	1.8	-1.9	-6.4	0.8	1.8	0.1	0.1
Blood Platelet Count	0.5	6.0	17.9	-1.2	-1.0	2.6	-0.9	1.0	-2.4	-2.0	2.3	-4.0	-4.2
Blood Red Count	2.8	26.8	92.0	-5.2	-9.6	-0.5	2.1	-2.1	-7.9	1.6	7.9	-1.7	-2.9
Blood White Count	1.5	11.0	28.3	-3.5	-4.1	-3.1	3.4	-3.3	-5.3	2.4	-0.1	2.2	3.1
Heel T-Score	1.7	13.4	30.8	-5.5	-3.9	-3.9	4.1	-3.7	-2.0	3.9	2.4	3.1	2.8
BMI	7.3	42.4	76.2	8.7	7.5	6.0	-7.7	7.5	5.9	-6.0	-5.4	-4.9	-4.0
Height	1.0	18.7	47.1	6.9	3.1	3.7	-6.1	5.5	4.5	-4.5	-2.4	-1.6	-1.1
Waist Hip Ratio (WHR)	2.1	9.5	15.9	3.0	0.2	4.0	-3.9	3.7	-2.1	-3.8	1.2	-3.0	-3.4
Systolic Blood Pressure	0.5	2.5	6.1	1.1	-2.5	1.0	-2.3	2.2	-0.8	-1.0	1.1	-1.2	-1.5
Smoking Status	0.2	0.5	1.4	0.2	0.8	-1.1	-0.1	-0.2	-0.8	1.2	0.7	0.2	-0.0
Allergy or Eczema	0.9	2.5	7.8	-2.3	-0.7	-1.3	2.8	-2.4	-0.1	1.3	0.2	1.1	0.8
Cardiovascular Disease	1.1	3.5	6.0	2.2	0.5	2.4	-2.2	2.3	-0.4	-2.1	0.3	-2.0	-2.4
Hypothyroidism (self reported)	0.4	1.0	8.5	-0.6	-2.9	-0.5	0.4	-0.4	-0.3	0.5	-0.6	0.2	0.4
Respiratory disease	1.6	3.6	10.6	1.2	2.8	0.9	-1.3	1.4	3.3	-1.4	-3.2	0.2	0.5
Type 2 Diabetes (T2D) (2018)	1.5	2.9	5.6	2.4	1.4	1.7	-1.7	2.1	2.1	-1.6	-0.3	-1.4	-1.3
Lung FEV1/FVC ratio	0.3	1.3	4.0	-0.9	-1.9	-0.3	0.5	-0.5	-1.9	0.5	2.0	-0.5	-0.4
Lung FVC	0.8	4.3	8.3	-2.9	-2.6	-1.6	2.0	-1.8	-2.0	1.2	2.0	2.2	1.8
Neuroticism	0.2	0.5	2.3	-0.6	1.5	-0.7	-0.4	0.4	-0.7	0.7	-0.4	0.6	0.6
Chronotype (morning person)	1.5	3.6	8.2	1.2	2.1	2.0	-2.4	2.9	1.8	-2.2	-0.6	-1.4	-1.1
Hair Pigment	0.0	0.3	2.3	-0.1	1.5	0.1	0.5	-0.3	-0.5	-0.2	-0.2	-0.2	0.2
Tanning	0.3	3.2	5.7	-1.6	-1.4	-2.0	2.2	-2.3	-0.8	1.7	0.7	2.4	2.0
Hand grip strength (left)	0.5	1.4	2.6	1.6	1.6	0.1	-1.4	1.5	1.6	-0.6	-1.2	0.2	0.3
Number of treatments/medications taken	0.2	0.4	1.0	1.0	1.0	0.0	-0.7	0.7	0.8	0.0	-0.5	0.6	0.2
Average weekly spirits intake	0.6	0.8	2.2	-0.1	-0.0	-0.9	1.5	-1.4	-0.5	1.2	0.9	0.3	0.2
Sensitivity / hurt feelings	1.0	1.7	5.1	-1.7	-0.9	-0.8	0.7	-1.0	-2.3	1.4	1.8	0.4	-0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	-0.5	0.8	-0.4	-0.1	0.2	-1.1	0.6	-0.4	-0.4	-0.2
Hearing difficulty/problems: Yes	0.4	0.6	1.4	1.1	0.5	0.7	-0.4	0.5	1.2	-0.6	-0.9	-0.5	-0.8
Relative age of first facial hair	1.3	2.7	5.8	-2.4	-1.5	-1.9	1.2	-1.2	-1.9	1.7	0.1	1.8	1.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.5	-1.2	-1.9	-1.1	1.0	-1.1	0.8	1.3	0.5	1.1	0.8
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.6	0.4	-0.2	0.1	-0.2	-0.0	-0.8	-0.0	-0.5	0.2	0.0
Ever had hysterectomy (womb removed)	0.6	0.7	2.8	0.3	0.6	-0.5	0.5	-0.5	-1.0	1.2	1.7	-0.2	-0.7
Systolic blood pressure, automated reading	0.5	1.4	2.6	0.7	-1.4	0.9	-1.4	1.4	-1.3	-0.4	0.5	-1.4	-1.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.5	0.5	0.6	0.2	0.4	0.1	0.7	-0.3	-0.2	0.4	0.1
Angina	1.3	1.7	5.3	-0.3	-1.3	-1.6	-0.3	0.1	0.4	1.1	-0.9	2.1	2.3
Medication for hormone replacement therapy	0.9	1.0	2.0	-1.4	-0.3	-1.0	0.8	-0.3	-1.4	0.9	-0.7	1.1	1.4
Vitamin and mineral supplements	0.2	0.2	2.0	0.0	0.4	0.3	-0.2	0.2	-1.4	-0.3	-0.1	0.1	0.2
Supplements: Zinc	0.8	0.9	2.7	0.7	0.7	0.5	-0.7	0.7	1.6	-0.9	-1.7	-0.5	-0.0
Medication: Co-codamol	1.0	1.1	3.6	1.2	0.5	0.9	-1.9	1.7	0.1	-1.0	0.2	-0.8	-0.8
Medication: Metformin	0.3	0.4	1.7	1.0	0.3	-0.0	-0.2	0.3	1.3	0.0	-0.8	-0.1	0.1
Diabetes (father)	3.5	4.4	10.2	3.2	2.3	1.9	-1.5	1.4	2.7	-2.2	-2.1	-1.6	-1.2
Diabetes (mother)	6.9	8.9	15.4	2.3	1.5	3.5	-3.7	3.9	2.6	-3.6	0.1	-3.2	-3.2
Severe depression (siblings)	0.6	0.6	1.3	0.4	0.4	0.7	-1.0	1.1	1.1	-0.7	-0.3	-0.9	-0.8
Pack years adult smoking proportion	0.4	0.6	1.5	1.2	1.2	0.6	-0.2	0.0	-0.7	-0.6	-0.5	-1.1	-0.7
Impedance of leg (right)	4.7	23.0	40.2	-6.3	-6.3	-4.0	5.6	-5.7	-4.3	4.1	3.9	3.5	2.7
Leg fat-free mass (left)	6.3	33.4	70.7	8.4	6.2	5.4	-6.8	7.0	4.9	-5.5	-5.1	-3.7	-2.6
Trunk fat percentage	3.9	15.5	27.5	5.2	2.8	4.5	-4.7	4.6	2.1	-3.9	-2.5	-4.0	-3.8
Hand grip strength (right)	0.2	0.7	2.9	1.7	0.9	-0.0	-0.7	0.9	0.9	-0.4	-0.8	0.1	0.3
Townsend deprivation index at recruitment	0.5	0.7	2.0	0.5	-1.4	0.8	-0.7	0.9	-0.1	-0.4	-0.3	-1.2	-1.1
Current tobacco smoking	0.1	0.2	0.7	-0.0	-0.1	-0.3	-0.2	0.2	-0.8	0.6	0.7	-0.5	-0.4
Average weekly fortified wine intake	2.8	3.3	8.1	-2.8	-1.4	-1.3	2.7	-2.5	0.3	1.3	2.3	1.0	0.3
Maternal smoking around birth	1.3	1.8	4.0	-1.3	-0.5	-1.9	1.6	-1.2	-1.0	2.0	0.0	1.2	1.5
Fed-up feelings	0.5	0.9	3.5	0.8	1.9	-0.5	-0.6	0.5	-0.2	0.6	-1.5	0.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	2.9	0.7	0.0	1.0	-1.7	1.5	0.1	-0.8	-0.2	-1.5	-1.7
Relative age voice broke	3.4	5.1	10.0	-3.0	-1.7	-2.5	1.9	-1.9	-3.2	2.5	0.5	2.2	1.9
Taking other prescription medications	0.4	0.6	2.7	0.6	0.8	0.3	-0.4	0.4	1.2	-0.1	-1.6	0.2	0.1
Age when periods started (menarche)	6.0	14.5	32.3	-5.2	-2.6	-3.6	5.7	-5.1	-1.0	3.6	3.3	3.1	2.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.2	1.2	1.5	0.4	-0.6	0.3	0.2	0.1	0.3	-1.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.3	-2.3	-1.1	-1.7	1.1	-0.9	-1.2	1.9	1.3	1.1	1.1
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	5.3	-1.0	-0.8	-2.3	2.1	-2.0	0.7	2.3	-0.5	2.2	2.2
Qualifications: CSEs or equivalent	0.9	1.1	3.6	0.2	-0.1	-1.6	0.6	-0.5	-1.1	1.9	-0.1	1.1	1.4
Serious illness, injury or assault to yourself	0.8	1.0	2.2	1.2	0.3	1.0	-1.5	1.3	0.7	-0.9	0.1	-1.2	-0.8
High blood pressure	1.6	4.4	8.1	2.3	0.1	2.6	-2.7	2.8	-0.1	-2.2	0.7	-2.3	-2.6
Hayfever, allergic rhinitis or eczema	0.7	1.5	5.4	-1.7	-0.4	-0.9	2.3	-1.9	0.6	1.0	-0.3	0.8	0.6
Multivitamins +/- minerals	0.1	0.2	0.6	-0.3	-0.3	-0.6	0.2	0.0	0.7	0.8	-0.2	0.1	0.0
Stomach or abdominal pain in last month	0.1	0.1	1.3	0.1	-0.3	0.1	0.0	-0.2	-1.1	0.3	-0.1	-0.1	0.0
Supplements: Glucosamine	0.4	0.5	2.3	0.7	1.1	-0.3	0.6	-0.7	1.5	0.3	-0.4	0.4	0.2
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.6	-0.3	-0.5	0.1	-0.2	0.3	-1.4	0.2	1.6	-0.2	-0.7
Medication: Atenolol	0.2	0.3	1.4	0.5	-0.3	0.5	-0.6	0.5	-1.2	-0.5	0.1	-0.3	-0.4
Medication: Levothyroxine sodium	1.1	1.8	2.8	0.7	-1.2	1.6	-1.5	1.5	0.5	-1.6	-1.6	-1.7	-1.3
Sitting height	0.4	2.9	6.0	2.4	-0.1	1.8	-2.1	2.2	1.0	-2.3	-1.9	-0.5	0.2
Chronic bronchitis/emphysema (father)	0.5	0.6	1.4	0.1	0.7	0.7	-1.0	1.2	-0.8	-0.7	-0.6	-0.9	-0.5
High blood pressure (mother)	0.6	0.8	2.5	1.4	0.2	0.7	-0.4	0.7	1.6	-0.4	0.5	-1.1	-1.1
Body mass index (BMI)	6.8	29.1	53.4	7.3	5.5	5.3	-6.3	6.4	4.0	-5.0	-4.3	-4.8	-4.0
Impedance of leg (left)	4.3	20.8	36.6	-6.0	-6.0	-3.9	5.2	-5.4	-3.8	4.0	4.0	3.3	2.4
Leg predicted mass (left)	6.4	33.8	71.2	8.4	6.2	5.4	-6.9	7.0	5.0	-5.5	-5.1	-3.7	-2.7
Trunk fat mass	6.1	26.4	51.4	7.2	4.2	5.5	-6.2	6.1	3.4	-5.2	-3.7	-4.5	-4.0
Waist circumference	12.1	44.2	85.2	9.2	5.7	7.5	-8.0	7.9	3.2	-7.0	-3.9	-6.1	-5.6
Number of incorrect matches in round	3.0	5.0	11.3	-3.4	-3.2	-1.6	2.6	-2.7	-2.2	1.8	1.2	1.1	1.1
Past tobacco smoking	0.3	0.5	1.4	-1.0	-0.6	0.1	0.7	-0.3	0.7	-0.1	-1.2	0.4	0.9
Alcohol usually taken with meals	1.0	1.6	4.4	0.9	2.1	1.4	-0.9	1.4	0.7	-1.9	-1.1	-0.6	-0.2
Nervous feelings	4.2	7.8	20.1	-4.5	-2.0	-3.3	2.8	-2.5	-1.8	3.2	1.4	2.6	2.6
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.5	-1.6	-1.4	-1.7	1.2	-1.1	-1.6	1.9	0.5	1.1	1.2
Hearing difficulty/problems with background noise	0.7	1.2	5.2	1.3	1.1	0.4	-0.8	0.7	1.4	-0.8	-2.3	-0.2	0.2
Hair/balding pattern: Pattern 2	0.5	0.6	1.1	-0.8	0.0	-0.9	0.9	-1.0	0.2	0.8	0.3	1.1	0.8
Had menopause	1.8	2.2	4.7	1.7	0.6	2.2	-1.4	1.2	-0.2	-1.9	-0.2	-1.8	-2.1
Had other major operations	0.2	0.3	1.0	0.4	0.9	0.2	-0.2	0.4	0.3	-0.3	-1.0	0.3	0.2
Forced vital capacity (FVC)	0.3	1.0	3.5	0.9	0.2	0.1	-0.8	0.6	0.4	-0.8	-0.9	1.7	1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	6.8	-2.6	-2.0	-1.8	1.8	-1.5	-0.4	1.8	0.9	1.5	1.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.9	-1.4	-0.5	-0.6	0.0	-0.2	-0.8	0.6	1.2	0.2	0.2
Qualifications: None of the above	0.4	0.8	2.7	1.3	-0.1	0.5	-0.7	1.0	-0.5	-0.2	-1.6	-1.1	-0.5
Financial difficulties in last 2 years	0.4	0.5	1.1	-0.5	-1.0	-0.7	-0.3	0.4	1.0	0.3	-1.1	0.6	1.0
Mouth/teeth dental problems	1.1	1.7	4.2	-1.1	-0.4	-1.2	1.4	-1.9	-0.1	0.5	1.1	2.1	1.7
Heart attack	0.1	0.2	0.5	0.6	-0.1	0.2	-0.7	0.3	-0.4	-0.5	-0.0	-0.3	-0.2
Allergy	0.7	1.5	2.9	1.7	0.1	1.3	-1.6	1.2	-0.8	-1.0	1.3	-1.1	-1.3
Pain all over the body in last month	0.5	0.5	1.4	1.1	-0.4	0.1	-1.1	1.2	1.0	-0.0	-0.5	0.3	0.1
Diabetes (self-reported)	0.4	0.6	2.6	1.2	0.8	0.3	-0.3	0.8	1.6	-0.3	-0.7	-0.2	0.0
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.9	-1.4	-0.9	-1.4	2.1	-2.2	-1.2	1.4	1.0	1.2	0.9
Medication: Ramipril	1.5	1.9	5.0	2.2	0.5	1.7	-1.4	1.3	0.9	-1.4	0.8	-1.3	-1.7
Medication: Simvastatin	0.5	0.8	2.4	-0.3	-0.7	0.5	0.2	0.2	-1.2	-0.1	1.5	-0.9	-1.3
Fluid intelligence score	0.2	0.4	1.5	0.0	0.6	-0.0	1.1	-1.0	1.2	0.1	-0.0	0.6	0.3
Illnesses of siblings	1.3	1.9	4.5	-1.0	-1.0	-1.3	1.3	-1.5	-0.8	1.3	0.1	2.1	2.1
Neuroticism score	0.2	0.4	0.7	-0.7	0.8	-0.6	-0.8	0.7	-0.7	0.6	0.1	0.2	0.2
Weight	8.9	43.7	87.6	9.4	6.2	6.7	-7.9	7.9	5.3	-6.6	-5.2	-5.1	-4.1
Impedance of arm (right)	2.0	9.3	22.6	-4.3	-4.8	-2.1	3.2	-3.5	-2.6	2.4	2.6	1.9	1.0
Arm fat percentage (right)	5.9	23.4	41.1	6.4	3.9	5.2	-5.9	5.8	3.2	-4.7	-3.7	-4.5	-4.1
Trunk fat-free mass	5.8	33.6	77.3	8.8	6.0	5.3	-6.7	6.8	5.4	-5.8	-5.1	-3.2	-1.9
Hip circumference	7.3	31.5	64.3	8.0	5.3	5.6	-6.3	6.3	5.1	-5.3	-5.1	-4.4	-3.7
Time employed in main current job	0.4	0.5	1.7	-1.0	-0.8	-0.1	-0.1	0.3	-0.8	0.4	1.3	-0.4	-0.7
Alcohol intake versus 10 years previously	2.5	3.7	7.7	2.4	1.6	2.0	-2.5	2.8	1.0	-2.2	-2.0	-1.0	-0.6
Father’s age at death	0.1	0.1	0.3	-0.1	0.1	0.0	0.1	-0.3	-0.0	-0.3	-0.2	0.4	0.5
Worrier / anxious feelings	2.0	3.9	7.6	-2.8	-0.2	-1.9	2.0	-2.2	-2.2	2.1	2.4	1.5	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.8	-0.1	-0.2	-0.2	-0.3	0.5	-0.9	0.6	-0.6	-0.2	-0.1
Falls in the last year	0.5	0.6	1.8	0.5	-1.3	-0.4	0.7	-0.8	0.2	0.4	-1.4	0.6	0.8
Hair/balding pattern: Pattern 3	1.2	1.7	5.5	-2.3	-1.2	-0.8	1.1	-0.6	-0.9	1.3	2.2	-0.5	-0.9
Number of live births	1.0	1.4	2.7	-1.4	-1.3	-1.4	1.6	-1.1	-1.4	1.5	0.4	0.5	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.4	0.9	0.2	0.6	-1.0	0.9	0.4	-1.2	-0.6	0.8	1.0
Pulse rate	0.6	1.0	2.2	-1.2	-0.8	-1.0	1.4	-1.5	-1.1	1.2	0.6	0.2	0.2
Happiness	0.1	0.2	0.7	-0.2	-0.3	-0.1	-0.0	0.2	0.8	0.1	-0.7	-0.4	0.2
Noisy workplace	0.1	0.2	0.7	0.4	0.4	0.1	0.2	0.3	0.9	-0.1	-0.3	0.3	0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.6	-1.2	-1.3	0.2	0.6	-0.6	-0.4	-0.5	1.1	0.6	0.3
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.3	7.5	-1.0	-0.4	-1.9	2.1	-1.7	-0.9	1.7	-1.4	2.6	2.7
Mouth/teeth dental problems: Dentures	1.9	3.3	6.4	2.2	0.6	1.9	-2.0	2.2	-1.3	-1.4	-0.5	-2.5	-2.3
Asthma	1.5	2.9	12.0	-0.2	1.4	-0.9	-0.1	0.3	2.5	0.3	-3.5	1.7	2.2
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	6.3	1.9	1.4	1.9	-2.5	2.2	1.0	-1.6	-0.4	-2.2	-2.0
Medication: Cholesterol lowering	1.0	1.6	4.3	-1.2	-1.2	-1.1	1.1	-0.8	-1.8	1.3	2.1	0.5	-0.0
Depression (self-reported)	0.2	0.2	0.7	0.4	0.0	0.3	-0.5	0.6	-0.6	-0.3	-0.9	0.2	0.2
Medication: Lansoprazole	0.4	0.4	1.1	-0.6	-0.1	-0.7	0.3	-0.1	-0.5	0.9	-1.0	0.8	0.7
Prospective memory result	1.4	1.7	3.1	1.5	0.3	1.8	-1.5	1.5	-0.2	-1.6	0.1	-1.4	-1.5
Lung cancer (father)	0.9	1.1	2.2	1.4	0.7	1.3	-1.5	1.2	0.1	-1.1	0.4	-0.8	-1.0
Illnesses of mother	0.2	0.2	0.7	-0.8	-0.6	-0.5	0.2	-0.2	-0.6	0.4	-0.1	0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	5.2	-0.2	-0.5	-0.7	0.4	-0.4	-0.4	0.0	-0.5	2.0	2.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.2	1.0	0.0	0.8	-1.1	0.8	-0.4	-0.9	-0.3	-0.4	-0.5
Impedance of arm (left)	2.8	13.2	26.5	-5.2	-5.0	-2.9	4.0	-4.2	-3.5	3.1	2.5	2.6	1.8
Arm fat mass (right)	8.3	34.1	67.9	8.2	5.3	6.0	-7.0	6.9	4.1	-5.7	-4.8	-4.9	-4.2
Trunk predicted mass	5.9	33.7	77.6	8.8	6.0	5.3	-6.7	6.8	5.4	-5.8	-5.1	-3.2	-1.9
Standing height	1.4	13.4	33.2	5.8	2.4	3.9	-4.5	4.4	3.1	-4.4	-3.0	-1.4	-0.8
Length of working week for main job	1.0	1.1	2.4	1.6	1.3	0.9	-1.2	1.1	0.9	-0.9	-0.8	-1.0	-0.7
Exposure to tobacco smoke at home	2.6	2.9	4.6	1.6	1.4	2.1	-2.0	1.8	0.2	-2.0	0.3	-2.0	-2.1
Breastfed as a baby	0.3	0.3	1.3	-0.2	-0.2	0.0	0.5	-0.0	1.1	-0.4	-1.1	0.2	0.4
Tense / ‘highly strung’	0.8	1.4	2.7	-1.6	-0.6	-1.4	1.0	-0.8	-1.5	1.3	0.3	1.3	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.6	-1.3	-1.9	-1.2	0.8	-1.0	-1.1	1.5	1.0	1.4	1.0
Hair/balding pattern: Pattern 4	0.6	1.6	7.6	1.4	0.9	0.8	-1.0	1.1	2.8	-1.1	-0.8	-0.6	-0.3
Birth weight of first child	0.2	0.4	1.7	1.0	0.9	0.3	-0.3	0.7	0.0	-0.3	-1.3	-0.1	0.4
Peak expiratory flow (PEF)	0.3	0.7	1.7	0.0	-0.8	1.1	-0.8	1.0	1.3	-1.2	-0.5	-0.3	-0.4
Pulse wave reflection index	0.5	0.6	1.1	1.1	0.5	0.6	-0.9	0.9	1.0	-1.0	-1.0	0.1	0.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.1	1.5	0.5	0.9	-1.3	1.3	1.2	-1.0	-0.2	-0.6	-0.4
Loud music exposure frequency	2.1	2.3	4.2	-2.0	-1.2	-1.8	2.0	-1.7	-0.7	2.0	-0.8	1.0	1.2
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	4.1	-0.3	0.1	0.7	-0.2	-0.1	2.0	-0.7	1.4	-0.5	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	1.5	-0.6	-0.6	-0.4	0.1	0.2	0.2	0.8	-1.2	0.0	0.3
Blood clot in the leg (DVT)	0.6	0.7	1.7	-0.8	0.3	0.4	-0.8	1.1	-1.3	-0.5	-0.4	-1.3	-0.9
Medication: Paracetamol	1.4	2.3	6.9	0.2	0.3	1.4	-2.6	2.5	-0.1	-1.2	-0.8	-1.7	-1.7
Headache pain in last month	0.4	0.6	1.7	-0.2	0.6	0.7	-1.0	0.9	-1.3	-0.6	-0.8	-0.7	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.8	0.1	0.6	0.1	-0.0	-0.2	1.1	-0.4	-1.7	0.1	0.5
Glaucoma (self-reported)	0.4	0.5	1.4	0.2	0.9	-0.3	-0.2	0.1	1.2	-0.0	-1.2	0.6	0.6
Gout (self-reported)	0.7	0.9	3.1	-0.7	-0.4	-0.8	0.7	-0.5	-1.0	0.7	-1.8	0.8	1.5
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	3.0	-0.3	-1.7	0.1	-0.4	0.4	-0.5	-0.1	-0.9	-0.1	0.0
Medication: Amlodipine	0.4	0.6	3.2	-0.2	-1.8	0.0	-0.5	0.6	0.4	0.3	1.3	-0.1	-0.4
Medication: Ventolin 100micrograms inhaler	1.1	1.4	8.1	0.2	2.8	-0.4	0.1	-0.2	1.4	-0.0	-1.6	0.8	0.9
Birth weight	0.2	0.3	1.4	-0.8	-0.2	-0.3	0.2	0.2	-1.2	0.4	-0.3	0.5	0.7
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.3	-1.6	0.2	-1.7	1.3	-1.3	-1.2	1.8	0.6	1.6	1.2
High blood pressure (siblings)	0.4	0.6	1.6	-0.8	-0.3	0.4	-0.7	1.2	-0.2	-0.6	-0.4	-1.1	-1.3
Forced vital capacity (FVC), Best measure	0.5	1.7	7.8	0.2	-0.4	-0.7	0.0	-0.2	0.1	-0.1	-1.4	2.5	2.8
Body fat percentage	4.2	16.8	28.6	5.3	2.9	4.6	-5.0	4.8	2.2	-4.1	-2.6	-4.2	-4.0
Leg fat percentage (right)	2.9	10.4	19.3	4.4	2.4	3.5	-3.8	3.8	1.7	-3.0	-2.2	-3.4	-3.1
Arm fat-free mass (right)	5.5	28.0	66.1	8.1	6.0	4.7	-6.1	6.3	4.3	-5.0	-4.5	-3.1	-2.0
Exposure to tobacco smoke outside home	0.4	0.5	1.1	-0.4	-1.0	-0.9	0.6	-0.7	0.4	1.1	-0.0	0.7	0.5
Comparative body size at age 10	3.9	10.7	19.7	3.3	4.4	3.1	-4.4	4.3	2.1	-2.9	-2.5	-2.1	-2.2
Number of full brothers	0.2	0.3	0.7	-0.3	-0.8	-0.0	-0.6	0.8	0.5	-0.2	-0.5	-0.7	-0.2
Worry too long after embarrassment	0.3	0.5	1.8	-1.1	-0.5	-0.6	0.4	-0.4	-1.3	0.4	-0.2	0.5	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.5	-1.8	-1.3	-1.4	1.0	-1.3	-1.9	1.6	1.8	1.6	0.9
Wheeze or whistling in the chest in last year	1.5	2.7	9.1	1.7	1.1	0.9	-1.4	1.7	2.6	-0.7	-3.0	-0.8	-0.2
Number of children fathered	1.0	1.1	5.2	1.0	1.2	0.1	-0.4	0.5	2.3	-0.4	-1.6	0.1	0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.7	-1.2	-1.2	-1.3	1.6	-1.6	-1.6	1.3	0.6	1.6	1.2
Age at first live birth	0.7	1.2	2.2	1.2	1.0	1.3	-0.8	0.5	0.8	-1.4	1.5	-0.9	-1.2
Pulse wave peak to peak time	0.4	0.4	1.1	-0.8	0.0	-0.7	1.0	-0.8	0.3	0.8	0.4	0.4	0.5
Health satisfaction	2.2	2.9	6.2	1.7	0.5	1.9	-2.2	2.5	0.8	-1.8	-2.1	-1.5	-1.0
Shortness of breath walking on level ground	2.9	3.4	4.7	2.0	1.8	2.0	-2.2	2.1	1.5	-1.9	-2.0	-1.8	-1.0
Qualifications: College or University degree	1.4	4.5	9.1	-3.0	-1.4	-1.9	2.6	-2.7	-1.7	1.0	0.3	2.2	2.6
Eye problems/disorders: None of the above	0.6	0.7	1.6	-0.2	0.3	-1.2	0.0	-0.2	-0.8	1.2	0.4	1.3	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	4.4	0.2	-0.0	0.2	-0.3	0.4	2.1	-0.3	-0.6	-0.2	-0.1
Emphysema/chronic bronchitis	0.3	0.4	1.4	0.6	1.2	0.5	-0.0	-0.1	-1.0	-0.7	-0.5	-0.2	-0.2
Medication for pain relief, constipation, heartburn	2.5	4.2	10.7	-1.4	-1.1	-2.3	3.3	-3.0	0.2	2.1	0.9	2.1	2.1
Neck or shoulder pain in last month	1.5	2.1	4.4	2.1	1.4	1.3	-1.4	1.6	1.9	-1.4	-1.5	-0.7	-0.6
Medication: Blood pressure	0.5	0.8	2.1	1.2	0.1	0.8	-1.4	1.4	-0.3	-0.6	0.4	-0.7	-1.0
Angina (self-reported)	1.3	1.7	5.0	-0.4	-1.4	-1.7	-0.0	-0.1	0.4	1.3	-0.8	2.1	2.2
Migraine (self-reported)	0.4	0.5	1.1	-0.8	-0.2	0.1	0.7	-0.7	-0.9	0.1	1.0	-0.6	-0.8
Medication: Ibuprofen	1.1	1.3	2.6	1.2	0.8	1.1	-1.6	1.3	0.7	-0.8	0.0	-1.4	-1.5
Medication: Allopurinol	1.2	1.6	8.4	-0.1	0.1	-0.9	0.7	-0.5	-0.5	0.7	-2.9	1.2	2.0
Medication: Omeprazole	0.2	0.2	1.0	-0.6	0.4	-0.2	0.4	0.1	-1.0	0.1	-0.2	0.5	0.5
Medication: Seretide 50 evohaler	1.7	1.9	7.5	1.2	2.3	0.7	-0.6	0.8	1.6	-1.0	-2.7	-0.2	0.3
Mean time to correctly identify matches	1.1	2.0	5.5	0.5	1.3	1.8	-1.1	0.9	0.7	-1.2	0.2	-2.4	-2.3
Heart disease (mother)	1.0	1.2	4.2	1.1	2.0	-0.2	-0.2	0.1	1.1	-0.2	-1.8	0.9	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	0.3	-0.7	0.2	-0.1	0.1	-0.1	0.2	0.8	-1.1	-1.2
Whole body fat mass	7.0	29.3	57.8	7.6	4.5	5.7	-6.5	6.4	3.6	-5.4	-4.0	-4.8	-4.2
Leg fat mass (right)	5.6	21.5	44.1	6.6	4.4	4.8	-5.5	5.5	3.1	-4.4	-3.5	-4.0	-3.5
Arm predicted mass (right)	5.8	29.5	69.7	8.3	5.9	4.9	-6.3	6.5	4.6	-5.2	-4.6	-3.3	-2.2
Pulse rate, automated reading	0.1	0.3	1.1	0.2	-0.1	0.4	0.0	-0.1	0.7	-0.1	0.3	-0.9	-1.0
Alcohol intake frequency.	7.2	16.8	33.3	4.6	2.2	3.8	-5.8	5.6	4.4	-4.1	-3.8	-2.7	-2.1
Comparative height size at age 10	2.7	14.7	35.9	6.0	3.0	3.9	-4.5	4.5	2.9	-4.5	-3.7	-1.6	-1.0
Number of full sisters	0.3	0.4	1.5	-0.1	-0.6	0.1	-0.9	1.2	0.4	-0.2	0.0	-0.8	-0.9
Suffer from ‘nerves’	2.7	4.2	9.5	-3.1	-1.6	-2.4	1.4	-1.5	-2.7	2.5	1.9	1.5	1.0
Overall health rating	0.7	1.6	2.7	1.6	0.5	1.4	-1.5	1.6	0.5	-1.5	-1.5	-0.8	-0.4
Chest pain or discomfort	0.6	0.8	1.7	-0.5	-1.3	-1.0	-0.7	0.8	0.7	0.7	-1.1	0.5	1.2
Had major operations	0.1	0.1	0.4	0.3	-0.3	-0.0	-0.1	0.4	0.6	0.0	-0.4	-0.2	0.1
Age at last live birth	2.1	3.0	5.4	1.2	0.8	2.2	-2.0	2.0	0.4	-2.1	0.7	-2.3	-2.3
Family relationship satisfaction	1.2	1.5	4.3	1.2	-0.2	0.9	-0.9	1.3	2.0	-1.2	-2.1	-0.1	0.7
Leg pain on walking	0.3	0.4	1.2	0.4	0.6	0.4	-0.5	0.7	0.5	-0.7	-1.1	-0.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.3	7.1	2.7	1.9	2.0	-2.0	1.8	1.9	-1.7	-0.4	-1.5	-1.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.4	-0.1	0.9	0.4	0.1	0.2	0.4	-0.4	-1.2	-0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	0.3	1.0	0.6	0.1	-0.1	0.5	-0.6	0.2	-0.7	-0.7
Medication: Aspirin	0.3	0.4	2.7	0.1	-1.1	-0.1	-0.6	0.4	-1.6	-0.0	0.0	0.2	0.1
Supplements: Vitamin C	0.6	0.7	3.8	0.6	-0.3	0.2	-0.5	0.4	1.9	-1.0	-1.1	0.1	0.3
Knee pain experienced in last month	1.8	2.7	4.8	0.7	2.1	1.5	-1.8	2.2	0.8	-1.6	-1.8	-1.9	-1.4
Hypertension (Self-reported)	1.3	3.6	6.8	1.8	-0.0	2.2	-2.4	2.4	-0.0	-1.8	1.1	-2.2	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.7	0.7	1.2	0.8	-0.7	1.0	0.5	-0.9	-1.6	-0.0	0.3
Illnesses of father: Heart disease	0.8	1.1	3.7	1.9	-0.1	0.9	-1.2	1.1	1.0	-0.9	-1.0	-1.0	-0.4
Illnesses of siblings: Diabetes	0.4	0.4	1.6	0.2	-0.8	0.3	-0.3	0.2	-0.2	0.2	0.9	-1.0	-1.3
Smoking status: Previous	0.2	0.3	1.1	0.7	0.3	-0.1	-0.7	0.2	-0.6	0.1	1.1	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.6	0.8	-0.1	0.8	-0.9	0.6	1.3	-0.8	-0.3	-0.1	0.1
Whole body fat-free mass	6.3	35.8	80.3	9.0	6.3	5.5	-7.0	7.1	5.3	-5.9	-5.2	-3.5	-2.4
Leg fat-free mass (right)	6.5	34.6	72.6	8.5	6.4	5.3	-7.0	7.1	5.2	-5.5	-5.1	-3.7	-2.6
Arm fat percentage (left)	5.3	21.2	37.1	6.1	3.8	4.9	-5.6	5.6	2.7	-4.5	-3.8	-4.2	-3.7
Average weekly red wine intake	0.4	0.5	2.9	-0.7	-0.6	0.1	0.1	0.3	-1.7	-0.2	0.5	-1.0	-0.4
Handedness (chirality/laterality): Left-handed	3.6	4.4	9.5	1.3	0.9	2.3	-2.4	2.5	1.1	-2.2	-0.9	-3.1	-2.8
Mood swings	0.2	0.4	1.8	-0.3	1.1	-0.3	-0.0	0.0	1.3	0.6	-0.5	0.1	-0.0
Loneliness, isolation	2.9	4.0	7.7	2.7	2.5	1.4	-2.8	2.3	1.0	-1.6	-2.3	-1.3	-0.9
Long-standing illness, disability or infirmity	1.4	2.1	7.0	1.7	2.5	0.4	-0.8	0.8	1.3	-0.7	-2.6	0.6	1.1
Ever had bowel cancer screening	0.4	0.4	1.0	-0.5	0.4	0.5	-1.0	0.9	-0.3	-0.8	0.5	-0.6	-0.7
Diabetes diagnosed by doctor	0.3	0.5	3.2	0.8	0.7	0.1	-0.2	0.5	1.8	0.1	-0.2	0.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.9	3.4	1.6	0.8	1.0	-1.8	1.3	1.8	-1.5	0.7	-1.3	-1.3
Friendships satisfaction	1.7	2.1	4.3	0.1	0.9	1.6	-2.1	2.0	0.2	-1.7	0.7	-1.8	-1.5
Qualifications: nursing, teaching	0.5	0.8	4.2	-1.3	-0.8	0.4	0.2	-0.4	0.2	-0.5	2.1	-0.2	-1.0
Commuting to job workplace: Walk	0.6	0.6	1.7	-0.9	-1.2	-0.3	0.9	-0.8	-1.3	0.4	0.7	0.4	0.3
Eye problems/disorders: Cataract	2.8	3.3	9.2	-2.2	-3.0	-0.1	2.1	-1.8	-2.3	0.8	2.0	-0.4	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.3	-0.1	0.7	-0.2	0.8	-0.5	1.1	0.6	1.1	-0.3	-0.4
Medication for cholesterol	1.7	2.5	6.9	-0.7	-0.2	-1.9	2.2	-2.6	0.3	1.8	-0.0	1.7	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.2	0.0	-0.1	0.4	0.1	0.3	-0.0	-0.2	-0.1	-0.1	-0.0
Back pain experienced in last month	0.4	0.6	1.3	1.1	-0.0	1.0	-1.0	0.8	0.4	-0.9	-0.2	-0.9	-0.6
Mineral and other dietary supplements	0.7	0.9	3.6	-0.2	0.9	0.6	-0.6	0.7	-0.8	-0.4	1.9	-1.1	-1.2
Breast cancer (self-reported)	0.2	0.2	0.8	-0.3	0.1	-0.5	0.5	-0.6	-0.9	0.6	0.1	0.3	0.4
Asthma (self-reported)	1.5	3.1	12.9	0.1	1.7	-0.4	-0.5	0.8	3.0	-0.2	-3.6	1.3	1.8
Osteoporosis (self-reported)	0.4	0.5	3.6	-0.2	-0.2	-0.0	0.6	-0.6	1.9	0.2	-0.0	0.2	-0.1
Osteoarthritis (self-reported)	0.4	0.5	4.0	-0.7	-0.3	-0.1	0.5	-0.2	-2.0	0.2	-0.3	0.1	0.4
Medication: Aspirin	0.2	0.3	1.0	0.4	-0.9	0.0	-0.7	0.6	-1.0	-0.2	-0.6	0.3	0.3
Medication: Gliclazide	0.9	1.0	2.4	-0.2	-0.5	-0.9	1.4	-0.7	0.6	1.0	-1.0	1.5	1.4
Illnesses of father: None of the above (group 1)	1.7	2.2	3.5	-1.0	0.9	-1.5	1.5	-1.9	-1.6	1.6	1.6	1.8	0.9
Smoking status: Current	0.2	0.2	0.6	-0.2	-0.4	-0.6	0.1	-0.1	-0.8	0.7	0.8	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	7.8	-2.8	-1.9	-2.3	2.1	-2.3	-2.2	1.8	1.0	2.2	2.1
Whole body water mass	6.3	36.1	80.5	9.0	6.5	5.5	-7.0	7.2	5.3	-5.8	-5.3	-3.6	-2.4
Leg predicted mass (right)	6.5	34.9	72.9	8.5	6.5	5.3	-7.0	7.1	5.3	-5.6	-5.1	-3.7	-2.6
Arm fat mass (left)	7.7	31.6	62.7	7.9	5.3	5.7	-6.7	6.7	3.8	-5.5	-4.7	-4.7	-3.9
Number of self-reported non-cancer illnesses	0.2	0.3	0.7	0.1	-0.6	0.6	-0.5	0.7	-0.4	-0.4	-0.3	-0.7	-0.8
Average weekly champagne plus white wine intake	1.5	2.0	3.6	-1.5	-0.7	-1.9	1.9	-1.7	1.2	1.8	0.6	1.3	1.0
Miserableness	0.1	0.2	1.5	-0.0	0.4	-0.8	0.0	-0.2	-0.1	1.2	0.4	0.2	0.1
Guilty feelings	3.7	5.6	13.4	1.7	1.4	2.4	-3.6	3.7	0.1	-2.5	-1.6	-2.3	-2.1
Wears glasses or contact lenses	0.5	0.6	1.2	-0.4	0.8	-0.8	0.5	-1.0	1.1	0.9	-0.0	0.9	0.6
Ever taken oral contraceptive pill	0.4	0.5	1.7	0.6	0.9	-0.5	0.6	-0.2	1.3	0.5	-0.3	0.6	0.8
Hearing aid user	0.5	0.6	1.6	1.3	0.3	0.9	-0.8	0.5	-0.8	-0.5	0.1	-0.7	-1.1
Mother’s age at death	3.8	4.7	10.3	2.4	1.9	2.4	-2.2	2.3	2.0	-3.2	-1.6	-1.9	-1.3
Financial situation satisfaction	1.2	1.5	3.4	1.5	0.4	1.3	-1.1	1.2	0.5	-1.1	-1.6	-1.8	-0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.2	0.9	1.3	0.8	-0.6	0.5	1.5	-0.9	-0.4	-0.8	-0.7
Commuting to job workplace: Public transport	0.1	0.1	0.5	-0.1	0.3	-0.5	0.1	-0.2	-0.2	0.4	-0.2	0.7	0.5
Eye problems/disorders: Glaucoma	0.8	0.9	3.7	1.1	1.9	0.4	-0.8	0.7	0.5	-0.8	-1.5	-0.4	-0.1
Medication: Blood pressure	3.1	5.8	10.6	2.6	1.6	2.8	-3.2	3.3	1.1	-2.8	0.1	-2.4	-2.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	0.4	-0.5	0.7	-0.3	0.6	0.7	-0.8	-0.5	-1.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	4.5	0.8	-0.5	-0.1	-0.0	-0.2	1.4	-0.4	-2.1	0.8	1.0
High cholesterol (Self-reported)	1.0	1.8	4.4	-1.6	-1.6	0.6	-0.1	0.5	-2.1	-0.2	1.5	-1.2	-1.9
Medication: Bendroflumethiazide	3.7	5.6	9.4	2.8	2.2	2.4	-2.9	3.1	2.3	-2.5	-0.5	-2.0	-2.0
Medication: Paracetamol	0.9	1.4	4.2	0.2	0.1	1.0	-2.0	2.0	0.2	-0.9	-0.4	-1.3	-1.3
Medication: Lisinopril	0.7	1.0	2.2	0.4	-0.1	0.7	-1.1	1.2	0.6	-0.5	1.5	-1.3	-1.3
Medication: Atorvastatin	3.3	4.1	6.4	-2.5	-2.3	-2.5	1.8	-1.7	-2.4	2.5	1.4	1.3	1.0
Illnesses of father: High blood pressure	0.7	0.9	2.1	-0.8	-1.4	-0.8	1.4	-1.3	0.6	1.1	-0.4	0.3	0.3
Alcohol drinker status: Never	0.1	0.1	0.4	-0.0	-0.3	0.1	-0.6	0.5	0.6	-0.1	-0.6	0.3	0.0
Ever smoked	0.6	1.1	2.6	1.6	0.9	0.6	-1.3	0.8	0.5	-0.6	1.0	-1.0	-1.4
Basal metabolic rate	6.9	38.1	84.3	9.2	6.4	5.7	-7.3	7.4	5.5	-6.0	-5.4	-3.9	-2.7
Leg fat percentage (left)	3.4	12.4	22.9	4.8	2.7	3.7	-4.3	4.1	2.0	-3.3	-2.4	-3.6	-3.4
Arm fat-free mass (left)	6.4	32.5	74.6	8.6	6.1	5.3	-6.6	6.8	4.8	-5.5	-4.5	-3.8	-2.7
Number of operations (self-reported)	0.2	0.4	1.3	1.0	1.2	0.4	-0.3	0.5	0.1	-0.1	-0.3	-0.4	-0.7
Average weekly beer plus cider intake	1.2	1.7	4.2	-0.4	-1.2	-1.3	1.5	-1.7	-1.3	1.6	2.1	0.6	-0.1
Irritability	0.5	0.8	2.3	0.8	1.2	0.3	-1.5	1.3	0.9	-0.4	0.1	-0.5	-0.4
Risk taking	1.7	2.4	6.6	0.7	1.1	-1.1	0.1	-0.5	2.4	0.3	-2.6	1.7	2.5
Ever had prostate specific antigen (PSA) test	1.1	1.3	2.4	-1.3	-1.5	-1.2	1.0	-1.0	-0.2	1.4	0.1	1.4	1.3
Fractured/broken bones in last 5 years	0.8	1.1	2.0	0.3	0.1	-1.1	1.2	-1.4	1.1	1.3	-1.0	0.8	1.1
Age started oral contraceptive pill	1.0	1.2	3.1	1.2	0.5	1.6	-0.9	0.7	0.4	-1.8	-0.8	-0.8	-1.3
Diastolic blood pressure, automated reading	0.5	1.6	2.9	1.3	-1.1	1.1	-1.5	1.4	-1.3	-0.7	0.4	-1.5	-1.7
Ever depressed for a whole week	1.6	2.0	3.5	-1.9	-1.6	-1.4	1.5	-1.3	-1.3	1.7	1.1	1.0	1.1
Unable to work because of sickness or disability	0.2	0.2	0.8	0.6	0.5	-0.5	-0.2	-0.2	0.0	0.4	-0.3	0.9	0.7
Commuting to job workplace: Cycle	0.3	0.4	0.8	0.8	0.9	0.2	-0.5	0.7	0.5	-0.5	-0.4	-0.8	-0.4
Myopia	0.3	0.4	1.2	-0.8	-0.8	-0.1	0.2	-0.6	1.0	0.2	1.1	0.2	-0.1
Vascular/heart problems diagnosed by doctor	0.9	2.5	5.8	-2.1	0.0	-1.7	2.4	-2.4	0.2	1.6	0.3	1.2	1.3
Cholesterol lowering medication	1.0	1.5	2.8	0.3	-0.7	1.4	-1.3	1.5	-1.1	-1.3	0.2	-1.6	-1.7
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.4	-1.2	0.2	-0.6	0.8	-0.5	-1.1	0.8	1.0	0.8	0.4
Pain experienced in last month	0.8	1.3	2.3	-0.7	-1.2	-1.4	1.2	-1.5	-0.8	1.1	0.6	1.1	1.2
Supplements: Calcium	0.6	0.6	1.4	0.3	-0.5	0.6	-1.2	0.7	1.0	-0.7	-0.7	-1.0	-0.8
Basal cell carcinoma (self-reported)	1.1	1.3	5.1	-1.2	-1.2	-0.7	1.2	-1.2	-2.3	0.7	0.2	0.6	1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	0.8	-0.1	0.4	-0.8	0.4	-0.2	-0.6	0.0	-0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.9	-0.9	-0.1	0.3	-0.5	0.7	-1.4	-0.3	-0.2	-1.2	-0.8
Heart disease (siblings)	0.3	0.4	0.9	0.8	-0.5	0.6	-0.9	0.9	-0.4	-0.4	-0.2	-0.5	-0.4
Alcohol drinker status: Previous	1.1	1.2	3.0	0.8	-0.4	0.9	-1.7	1.7	-1.2	-1.0	-0.9	-1.0	-0.6
Pack years of smoking	0.6	0.9	2.4	1.6	1.2	0.9	-0.3	0.1	-0.7	-0.8	-0.8	-1.4	-0.9
Impedance of whole body	3.8	19.3	37.3	-6.0	-6.1	-3.5	4.8	-5.0	-4.3	3.7	3.8	3.0	1.9
Leg fat mass (left)	5.9	23.1	47.2	6.9	4.5	4.9	-5.7	5.6	3.3	-4.5	-3.6	-4.2	-3.6
Arm predicted mass (left)	6.5	32.9	75.3	8.7	5.9	5.4	-6.7	6.8	4.8	-5.5	-4.5	-4.0	-2.9