TWAS hub - CORO1A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.060	0.0330	4.6e-03	0.025	NA	0.000	NA	0.003	1.6e-02	NA	3.4e-01	NA	2.0e-01
2	YFS	Blood	0.171	0.0421	6.1e-16	0.033	0.06	0.077	0.127	0.065	5.1e-11	6.7e-19	7.0e-24	1.9e-39	1.7e-20

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Red Count	20.8	200.7	320.4	17.9	9.0
Weight	18.7	92.1	169.0	-13.0	-3.9
Leg fat-free mass (right)	18.5	99.0	176.9	-13.3	-4.6
Waist circumference	18.3	67.0	121.0	-11.0	-3.6
Leg predicted mass (right)	18.3	97.5	174.2	-13.2	-4.6
Leg fat-free mass (left)	17.6	93.2	166.4	-12.9	-4.5
Leg predicted mass (left)	17.6	93.3	166.4	-12.9	-4.5
Basal metabolic rate	17.6	97.6	176.9	-13.3	-4.3
Arm fat mass (left)	16.9	69.6	127.7	-11.3	-3.4
Number of incorrect matches in round	16.8	28.0	46.2	6.8	3.1
Arm fat mass (right)	16.8	69.1	127.7	-11.3	-3.2
Hip circumference	16.3	70.3	130.0	-11.4	-3.3
Impedance of leg (right)	16.2	78.4	132.2	11.5	5.0
Whole body water mass	16.1	92.0	166.4	-12.9	-4.2
Body mass index (BMI)	16.0	68.3	123.6	-11.1	-3.6
Arm predicted mass (left)	15.9	80.7	148.8	-12.2	-3.5
Whole body fat-free mass	15.8	90.5	163.8	-12.8	-4.1
Arm fat-free mass (left)	15.7	79.6	146.4	-12.1	-3.6
BMI	15.1	87.7	151.3	-12.3	-4.9
Arm fat-free mass (right)	14.6	74.8	139.2	-11.8	-3.2
Arm predicted mass (right)	14.4	73.7	136.9	-11.7	-3.2
Impedance of leg (left)	14.3	69.6	114.5	10.7	5.0
Trunk predicted mass	13.6	77.8	141.6	-11.9	-3.7
Impedance of whole body	13.6	69.2	118.8	10.9	4.4
Trunk fat-free mass	13.5	77.8	141.6	-11.9	-3.7
Leg fat mass (left)	12.8	49.9	94.5	-9.7	-2.3
Whole body fat mass	12.7	53.0	98.6	-9.9	-2.7
Leg fat mass (right)	11.6	45.0	85.0	-9.2	-2.2
Trunk fat mass	10.8	46.3	87.0	-9.3	-2.4
Arm fat percentage (right)	10.0	39.5	72.6	-8.5	-2.5
Arm fat percentage (left)	9.9	39.7	73.4	-8.6	-2.4
Impedance of arm (left)	8.6	39.7	71.7	8.5	2.8
Impedance of arm (right)	8.2	38.4	71.9	8.5	2.2
Qualifications: NVQ or HND or HNC or equivalent	8.0	9.7	18.8	-4.3	-0.8
Comparative body size at age 10	7.7	21.2	33.1	-5.8	-3.1
Blood Eosinophil Count	7.4	57.1	91.2	9.6	4.8
Wheeze or whistling in the chest in last year	6.8	12.2	24.1	-4.9	-0.5
Neck or shoulder pain in last month	6.8	9.7	16.3	-4.0	-1.8
Diabetes (father)	6.7	8.3	15.9	-4.0	-0.8
Age when periods started (menarche)	6.6	15.9	30.7	5.5	1.0
Alcohol intake versus 10 years previously	6.4	9.6	15.7	-4.0	-1.9
Number of children fathered	6.1	6.8	12.1	-3.5	-1.3
Body fat percentage	5.9	23.4	45.0	-6.7	-1.4
Medication: Bendroflumethiazide	5.7	8.6	14.0	-3.7	-1.8
Eye problems/disorders: Cataract	5.6	6.5	9.6	3.1	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	5.5	7.1	12.6	3.5	1.3
Alcohol intake frequency.	5.5	12.7	23.8	-4.9	-1.3
Trunk fat percentage	5.3	21.1	40.6	-6.4	-1.2
Nervous feelings	5.3	9.9	17.2	4.1	1.6
Basal cell carcinoma (self-reported)	5.3	6.3	6.9	2.4	2.6
Primary Biliary Cirrhosis	5.2	7.4	8.9	-3.0	-2.4
Leg fat percentage (left)	5.2	18.8	37.1	-6.1	-0.7
Hand grip strength (left)	5.1	13.3	22.3	-4.7	-2.1
Schizophrenia (2014)	5.0	11.1	19.8	4.5	1.6
Tense / ‘highly strung’	5.0	8.3	15.1	3.9	1.2
Comparative height size at age 10	5.0	27.7	51.8	-7.2	-1.9
Relative age voice broke	4.9	7.5	11.7	3.4	1.8
Chronotype (morning person)	4.8	11.0	14.1	-3.8	-2.8
Bipolar Disorder or Schizophrenia	4.7	11.6	22.8	4.8	0.6
Suffer from ‘nerves’	4.7	7.3	11.8	3.4	1.7
Body Mass Index (BMI) (2010)	4.6	6.3	11.7	-3.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.5	9.5	14.2	3.8	2.2
Schizophrenia (2018)	4.3	9.0	17.9	4.2	-0.4
Leg fat percentage (right)	3.7	13.3	26.5	-5.1	-0.5
Frequency of tenseness / restlessness in last 2 weeks	3.6	5.6	8.0	2.8	1.8
Illnesses of father: High blood pressure	3.5	4.4	7.8	-2.8	-1.0
Worry (Nagel 2018)	3.4	7.1	13.7	3.7	0.7
Hand grip strength (right)	3.4	9.1	15.4	-3.9	-1.7
Relative age of first facial hair	3.3	6.8	10.5	3.2	1.8
High blood pressure (mother)	3.2	4.5	8.2	-2.9	-0.9
Mouth/teeth dental problems: Dentures	3.2	5.4	9.5	-3.1	-1.1
Blood White Count	3.1	22.6	22.7	4.8	4.8
Seen doctor (GP) for nerves, anxiety, tension or depression	3.1	4.7	9.1	3.0	-0.5
Ever had hysterectomy (womb removed)	3.0	3.4	4.6	1.5	2.1
Asthma (self-reported)	3.0	6.0	12.0	-3.5	0.0
Ever taken oral contraceptive pill	3.0	3.3	5.8	-2.4	-1.0
Ulcerative Colitis	2.9	4.3	8.5	-2.9	-0.1
Type 2 Diabetes (T2D) (2018)	2.9	5.4	10.6	-3.3	-0.3
Time employed in main current job	2.9	3.3	3.5	1.8	1.9
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.7	6.7	-2.6	-0.8
Heel T-Score	2.8	22.0	37.2	6.1	2.6
Lung FEV1/FVC ratio	2.8	14.4	25.7	5.1	1.8
Diabetes (mother)	2.8	3.6	4.1	-2.0	-1.7
Hearing difficulty/problems with background noise	2.8	4.4	5.2	1.9	2.3
Leg pain on walking	2.8	3.5	4.4	-2.1	-1.6
Long-standing illness, disability or infirmity	2.7	4.1	8.1	-2.8	-0.4
Asthma	2.6	5.2	10.2	-3.2	0.3
Medication: Aspirin	2.6	3.5	3.6	1.8	1.9
Ever unenthusiastic/disinterested for a whole week	2.5	3.1	6.1	2.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	3.0	4.1	-2.0	-1.3
Bipolar Disorder (2018)	2.4	3.7	5.6	2.4	1.4
Respiratory disease	2.4	5.3	10.2	-3.2	-0.6
Fed-up feelings	2.4	4.3	8.6	-2.9	-0.3
Mouth/teeth dental problems	2.4	3.7	7.1	2.7	0.6
Qualifications: College or University degree	2.4	7.6	15.2	3.9	0.0
Family relationship satisfaction	2.4	3.0	3.1	1.7	1.8
Falls in the last year	2.3	3.1	5.9	-0.6	2.4
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	5.3	2.3	0.7
Lupus	2.2	3.3	6.6	-0.2	-2.6
High blood pressure	2.2	6.1	8.5	-2.9	-1.9
Rheumatoid Arthritis	2.1	2.9	4.5	-2.1	-1.2
Height	2.1	39.8	76.2	-8.7	-1.9
Medication: Gliclazide	2.1	2.3	4.7	-2.2	-0.1
Average weekly fortified wine intake	2.0	2.3	3.7	1.9	1.0
Supplements: Glucosamine	2.0	2.5	3.6	-1.9	-1.2
Medication: Aspirin	2.0	2.7	3.0	1.5	1.7
Medication: Lansoprazole	1.9	2.2	4.4	-0.2	-2.1
Medication: Ventolin 100micrograms inhaler	1.9	2.5	2.5	-1.5	-1.6
Heart disease (mother)	1.9	2.3	4.3	-2.1	-0.5
Supplements: Vitamin C	1.9	2.3	3.5	1.9	1.0
Eye problems/disorders: Glaucoma	1.9	2.2	4.2	-2.0	-0.5
High cholesterol (Self-reported)	1.9	3.3	5.0	2.2	1.3
Heart attack/myocardial infarction (self-reported)	1.9	2.4	4.8	0.1	2.2
Ulcerative Colitis (UC)	1.8	3.3	6.2	-2.5	-0.7
Standing height	1.8	18.3	35.5	-6.0	-1.1
Blood clot in the leg (DVT)	1.8	2.3	4.0	2.0	0.7
Hypertension (Self-reported)	1.8	5.1	6.3	-2.5	-2.0
Medication: Blood pressure	1.8	3.5	4.9	-2.2	-1.4
Number of treatments/medications taken	1.7	3.0	4.5	-2.1	1.2
Happiness	1.7	2.0	3.9	2.0	0.4
Medication: Seretide 50 evohaler	1.7	1.9	3.4	-1.9	0.6
Diabetes diagnosed by doctor	1.7	2.8	5.5	-2.4	-0.0
Illnesses of father: None of the above (group 1)	1.7	2.1	3.5	1.9	-0.9
Depressed Affect (Nagel 2018)	1.6	3.4	4.9	-2.2	-1.4
Schizophrenia vs Biploar Disorder	1.6	2.1	3.7	0.7	-1.9
Maternal smoking around birth	1.6	2.3	4.5	-2.1	-0.3
Heart attack	1.6	2.0	4.0	0.0	2.0
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.7	-1.9	0.4
Miserableness	1.6	2.8	4.4	-1.1	-2.1
Ever depressed for a whole week	1.6	2.0	3.8	2.0	0.3
Vascular/heart problems diagnosed by doctor	1.6	4.3	7.3	2.7	1.2
Medication: Metformin	1.5	2.1	4.2	-2.1	0.0
Diabetes (self-reported)	1.5	2.3	4.7	-2.2	-0.1
Qualifications: A levels/AS levels or equivalent	1.5	3.2	6.3	2.5	0.4
Glaucoma (self-reported)	1.5	1.7	3.5	-1.9	-0.1
Medication: Blood pressure	1.5	2.6	4.4	-2.1	-0.9
Medication: Ibuprofen	1.5	1.8	3.7	-1.9	-0.1
Breast cancer (self-reported)	1.5	1.7	2.9	-0.7	1.7
Knee pain experienced in last month	1.4	2.2	3.1	-1.1	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	4.6	-2.1	-1.1
Risk taking	1.4	2.1	2.5	-1.3	-1.6
LDL Cholesterol	1.3	2.1	4.1	2.0	0.3
Allergy or Eczema	1.3	3.4	4.9	1.4	2.2
Serious illness, injury or assault to yourself	1.3	1.6	2.4	-1.6	0.9
Medication: Simvastatin	1.3	1.9	2.2	1.5	1.3
Worrier / anxious feelings	1.3	2.5	4.8	2.2	-0.3
Medication: Cholesterol lowering	1.3	2.0	2.0	1.4	1.4
Illnesses of mother	1.3	1.6	3.2	1.8	0.1
Supplements: Calcium	1.3	1.4	2.4	1.6	0.7
Age at First Birth	1.2	1.7	3.1	0.5	1.8
Taking other prescription medications	1.2	1.8	3.5	-1.9	0.2
Hayfever/allergic rhinitis (self-reported)	1.2	1.7	2.7	1.6	0.8
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.7	-1.6	-0.1
Illnesses of father: Heart disease	1.2	1.7	3.3	-0.4	1.8
Medication: Lisinopril	1.2	1.5	1.8	-1.4	-1.1
Alzheimer’s Disease (in mother)	1.1	1.3	2.2	1.5	0.6
Alzheimer’s Disease (including proxy)	1.1	1.6	3.2	1.8	-0.1
Hypothyroidism (self reported)	1.1	2.5	2.6	1.6	1.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.4	-1.5	-0.4
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	1.7	0.9	1.3
Medication: Ramipril	1.1	1.4	1.6	-1.3	-1.1
Hair/balding pattern: Pattern 3	1.1	1.6	3.2	1.8	0.2
Birth weight of first child	1.1	2.0	4.0	-2.0	-0.1
Pulse wave reflection index	1.1	1.3	2.5	-0.4	-1.6
Exposure to tobacco smoke outside home	1.1	1.5	2.9	0.3	1.7
Mean time to correctly identify matches	1.1	2.1	3.2	1.8	1.0
Wears glasses or contact lenses	1.1	1.3	2.0	-1.4	0.8
Smoking Status	1.0	2.4	3.3	-1.8	-1.2
Angina	1.0	1.3	2.5	-1.6	0.4
Forced vital capacity (FVC)	1.0	4.0	7.6	-2.8	-0.7
Number of live births	1.0	1.5	2.8	1.7	0.3
Pulse rate	1.0	1.6	1.6	1.3	1.3
Had major operations	1.0	1.1	1.9	1.4	0.6
Fractured/broken bones in last 5 years	1.0	1.2	1.8	-0.8	-1.3
Myopia	1.0	1.4	2.8	1.7	-0.1
Neuroticism (2016)	0.9	1.3	1.6	1.0	1.2
Medication: Co-codamol	0.9	1.1	1.7	-1.3	-0.7
Had menopause	0.9	1.1	1.6	0.7	1.3
Had other major operations	0.9	1.1	1.3	-1.0	1.2
Medication: Paracetamol	0.9	1.5	2.7	-1.6	0.5
Birth weight	0.9	1.9	3.8	-1.9	-0.1
Medication for pain relief, constipation, heartburn	0.9	1.5	2.1	1.4	-0.9
Mood swings	0.9	1.5	1.6	-1.2	-1.3
Prostate Cancer	0.8	1.2	1.9	1.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	2.8	1.7	1.0
Pain all over the body in last month	0.8	0.9	1.7	-1.3	-0.3
Breastfed as a baby	0.8	1.0	1.5	0.7	-1.2
Angina (self-reported)	0.8	1.1	2.1	-1.4	0.3
Number of full sisters	0.8	1.0	1.5	-0.7	-1.2
Age at last live birth	0.8	1.2	2.3	1.5	0.3
Number of operations (self-reported)	0.8	1.2	1.8	-1.3	0.8
Commuting to job workplace: Cycle	0.8	1.0	1.5	1.2	0.7
Pain experienced in last month	0.8	1.4	2.4	0.5	1.6
Crohns Disease (2012)	0.7	1.1	1.8	1.3	0.7
Mean Putamen Volume	0.7	0.8	1.2	-1.1	0.7
Cardiovascular Disease	0.7	2.3	3.2	-1.8	-1.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.3	1.1	0.8
Alcohol usually taken with meals	0.7	1.1	1.2	-1.1	-1.0
Emphysema/chronic bronchitis	0.7	0.8	1.1	-0.7	-1.1
Friendships satisfaction	0.7	0.8	1.7	1.3	-0.2
Cholesterol lowering medication	0.7	1.1	1.3	1.1	0.9
Lung FVC	0.6	2.9	4.5	2.1	1.2
Medication for hormone replacement therapy	0.6	0.7	1.1	1.1	0.4
Pack years adult smoking proportion	0.6	0.8	1.7	-0.2	-1.3
Current tobacco smoking	0.6	1.0	1.4	-1.2	-0.8
Past tobacco smoking	0.6	1.1	1.8	1.4	0.6
Qualifications: None of the above	0.6	1.4	1.4	-1.2	1.1
Allergy	0.6	1.4	2.7	0.3	-1.6
Length of working week for main job	0.6	0.6	1.2	-1.1	0.3
Exposure to tobacco smoke at home	0.6	0.6	0.9	-1.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.1	1.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.8	1.2	1.1	0.6
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.3	-1.2	-0.2
Medication: Allopurinol	0.6	0.8	1.6	-0.3	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.0	0.6	1.0
Average weekly red wine intake	0.6	0.8	0.9	0.9	0.9
Loneliness, isolation	0.6	0.9	1.0	-0.8	-1.0
Osteoporosis (self-reported)	0.6	0.8	1.5	-1.2	-0.2
Average weekly champagne plus white wine intake	0.6	0.8	0.8	0.9	0.9
Mother’s age at death	0.6	0.7	1.4	1.2	0.2
Alcohol drinker status: Never	0.6	0.8	1.1	-1.0	0.7
Ever smoked	0.6	1.0	1.7	-0.6	-1.3
Crohns Disease (2017)	0.5	1.2	1.3	1.1	1.0
Major Depression (MDD)	0.5	0.6	1.2	1.1	0.2
Fasting Glucose	0.5	0.6	1.0	1.0	0.4
Triglycerides	0.5	0.9	1.7	-1.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.7	-0.6	-0.9
Qualifications: CSEs or equivalent	0.5	0.6	1.2	-1.1	0.0
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.0	0.0	1.4
Hair/balding pattern: Pattern 2	0.5	0.7	1.0	0.6	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.2	1.5	0.5
Noisy workplace	0.5	0.6	1.1	-1.0	-0.4
Shortness of breath walking on level ground	0.5	0.6	1.1	-1.0	0.3
Illnesses of siblings: Diabetes	0.5	0.6	1.1	-1.1	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.2	-0.0	-1.1
Commuting to job workplace: Walk	0.5	0.5	0.8	0.9	0.4
Smoking status: Current	0.5	0.8	1.2	-1.1	-0.7
Medication: Paracetamol	0.5	0.8	1.1	-0.6	1.1
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	1.0	-0.0
Unable to work because of sickness or disability	0.5	0.6	0.7	-0.7	-0.9
Pack years of smoking	0.5	0.8	1.5	0.1	-1.2
Depression (Nagel 2018)	0.4	0.7	1.1	1.1	0.5
Blood Platelet Count	0.4	4.9	8.0	2.8	1.4
Sensitivity / hurt feelings	0.4	0.8	1.5	1.2	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.6	0.8	-0.6
Fluid intelligence score	0.4	0.9	1.5	-1.2	-0.5
Illnesses of siblings	0.4	0.5	0.8	0.9	-0.5
Depression (self-reported)	0.4	0.5	0.7	0.8	-0.5
Loud music exposure frequency	0.4	0.4	0.8	-0.9	0.2
Gout (self-reported)	0.4	0.5	0.8	-0.5	-0.9
Eye problems/disorders: None of the above	0.4	0.4	0.7	-0.8	-0.5
Migraine (self-reported)	0.4	0.5	1.0	1.0	-0.1
Medication: Omeprazole	0.4	0.4	0.8	-0.9	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.8	0.9	0.2
Qualifications: nursing, teaching	0.4	0.6	0.8	0.9	-0.7
Osteoarthritis (self-reported)	0.4	0.6	1.0	-0.4	1.0
Commuting to job workplace: Public transport	0.4	0.5	0.9	-0.1	1.0
Reaction Time	0.3	0.6	0.9	0.9	0.6
Breast Cancer	0.3	0.8	1.1	-0.7	1.1
Ovarian Cancer	0.3	0.3	0.7	0.2	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.4	-0.6	0.5
Systolic blood pressure, automated reading	0.3	0.9	1.5	-1.2	-0.6
Vitamin and mineral supplements	0.3	0.4	0.9	0.1	-0.9
Severe depression (siblings)	0.3	0.3	0.4	-0.5	0.7
Medication: Atenolol	0.3	0.3	0.3	-0.6	0.6
Medication: Levothyroxine sodium	0.3	0.4	0.9	0.9	0.0
Sitting height	0.3	1.8	2.8	-0.9	1.7
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.7	-1.3	-0.2
Prospective memory result	0.3	0.4	0.4	0.7	0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.9	0.1	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	2.1	-1.5	-0.1
Smoking status: Previous	0.3	0.5	0.9	-1.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.8	-0.9	-0.5
Mineral and other dietary supplements	0.3	0.4	0.5	0.5	0.7
Number of self-reported non-cancer illnesses	0.3	0.5	1.0	-0.0	1.0
Guilty feelings	0.3	0.4	0.8	-0.9	-0.1
Tinnitus: Yes, now most or all of the time	0.3	0.4	0.4	0.6	-0.6
Medication: Atorvastatin	0.3	0.3	0.4	0.7	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.7	-0.8	-0.6
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	-0.9	0.2
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.4	-0.6	-0.6
Systolic Blood Pressure	0.2	1.1	1.2	-1.1	-1.0
Average weekly spirits intake	0.2	0.2	0.3	0.2	0.6
Multivitamins +/- minerals	0.2	0.2	0.4	-0.7	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	-0.6	0.1
Lung cancer (father)	0.2	0.2	0.2	-0.5	-0.4
Hair/balding pattern: Pattern 4	0.2	0.6	0.6	-0.7	-0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.3	0.5	-0.5
High blood pressure (siblings)	0.2	0.4	0.6	-0.4	0.8
Number of full brothers	0.2	0.2	0.2	0.4	-0.5
Worry too long after embarrassment	0.2	0.3	0.5	0.7	0.3
Pulse rate, automated reading	0.2	0.5	0.8	0.9	0.4
Overall health rating	0.2	0.4	0.8	-0.9	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.1	-0.6
Ever had bowel cancer screening	0.2	0.2	0.5	0.7	-0.1
Back pain experienced in last month	0.2	0.3	0.5	-0.3	-0.7
Age started oral contraceptive pill	0.2	0.3	0.3	0.4	0.6
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.4	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.2	-0.4
HbA1C	0.1	0.2	0.3	-0.5	-0.0
Waist Hip Ratio (WHR)	0.1	0.3	0.5	-0.7	-0.4
Tanning	0.1	1.2	2.3	1.5	-0.0
Hearing difficulty/problems: Yes	0.1	0.1	0.1	0.3	0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.3	0.2	0.5
Supplements: Zinc	0.1	0.2	0.3	-0.6	0.0
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.3	0.4
Financial difficulties in last 2 years	0.1	0.1	0.1	-0.3	-0.3
Neuroticism score	0.1	0.3	0.5	0.3	-0.7
Father’s age at death	0.1	0.1	0.2	0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.2	0.5	0.4
Peak expiratory flow (PEF)	0.1	0.1	0.3	-0.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.1	-0.1	0.4
Headache pain in last month	0.1	0.1	0.2	0.4	0.1
Medication: Amlodipine	0.1	0.1	0.1	-0.3	0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.4	-0.1
Age at first live birth	0.1	0.1	0.3	-0.0	0.5
Pulse wave peak to peak time	0.1	0.1	0.2	-0.2	-0.4
Health satisfaction	0.1	0.1	0.1	0.0	0.4
Chest pain or discomfort	0.1	0.1	0.1	-0.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.5	-0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.3	-0.3	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.2	-0.6
Irritability	0.1	0.2	0.3	-0.5	-0.3
Diastolic blood pressure, automated reading	0.1	0.2	0.4	-0.6	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.4	0.1
Heart disease (siblings)	0.1	0.2	0.3	-0.2	0.6
Neuroticism (Nagel 2018)	0.0	0.0	0.0	0.1	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.1	0.1	0.4	-0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Neuroticism	0.0	0.1	0.2	-0.1	-0.5
Hair Pigment	0.0	0.9	1.8	0.0	-1.3
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.2	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	0.0	-0.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	-0.1	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	-0.3	-0.1
Medication for cholesterol	0.0	0.0	0.1	0.1	0.3
Hearing aid user	0.0	0.0	0.1	-0.3	0.1
Financial situation satisfaction	0.0	0.0	0.1	-0.1	0.3
Average weekly beer plus cider intake	0.0	0.1	0.1	0.3	0.1

Hub : Genes

CORO1A

Models

Trait associations