TWAS hub - CAD

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pancreas	0.2250	0.0630	5.5e-07	0.231	NA	0.192	NA	0.212	3.9e-10	NA	1.5e-08	NA	2.4e-09
2	GTEx	Thyroid	0.0730	0.0350	3.0e-04	0.015	NA	0.023	NA	0.021	2.4e-02	NA	6.1e-03	NA	9.1e-03
3	TCGA	Liver Hepatocellular Carcinoma	0.0740	0.0460	4.4e-03	0.051	0.033	0.011	NA	0.025	2.1e-03	0.0110	9.5e-02	NA	2.3e-02
4	TCGA	Lung Squamous Cell Carcinoma	0.0412	0.0296	9.8e-03	0.005	0.016	0.002	NA	0.004	8.6e-02	0.0061	1.9e-01	NA	1.1e-01
5	TCGA	Testicular Germ Cell Tumors	0.1330	0.0790	8.0e-03	0.079	0.052	0.063	NA	0.070	9.8e-04	0.0063	2.9e-03	NA	1.8e-03
6	TCGA	Uterine Corpus Endometrial Carcinoma	0.1810	0.1070	9.2e-03	0.061	0.031	0.055	NA	0.024	8.7e-03	0.0470	1.2e-02	NA	7.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Triglycerides	24.5	40.1	96.2	-4.8	3.4	-9.8	-5.8	-8.3	-2.7
Had menopause	8.4	10.5	33.9	3.5	-5.8	3.0	-0.4	0.5	-2.7
Medication for pain relief, constipation, heartburn	8.1	13.8	22.2	4.7	-4.3	3.2	-3.1	-0.8	-4.6
High cholesterol (Self-reported)	5.7	10.1	25.6	-2.4	1.9	-5.1	-2.5	-4.3	-0.8
Fasting Glucose	5.6	6.7	18.6	2.9	-2.6	4.3	1.6	1.8	-0.9
Medication: Ibuprofen (e.g. Nurofen)	5.6	7.1	14.6	-3.1	3.1	-1.9	2.2	1.1	3.8
Gout (self-reported)	4.6	6.3	13.5	-2.7	3.4	-3.7	-0.5	-1.7	1.5
Blood Platelet Count	4.4	51.0	127.7	-8.7	6.2	-11.3	-3.1	-6.2	4.0
Vitamin and mineral supplements	4.4	5.9	10.6	3.3	-2.7	2.5	-1.6	0.1	-3.0
Alcohol intake frequency.	4.3	9.9	25.6	-2.8	1.5	-5.1	-2.7	-3.8	1.4
Medication: Ibuprofen	4.1	4.9	10.8	-2.7	2.3	-1.9	1.4	0.6	3.3
Age when periods started (menarche)	4.0	9.5	18.9	2.1	-4.2	-0.6	-4.3	-2.9	-2.7
Number of operations (self-reported)	3.9	5.8	13.0	-3.6	2.2	-2.5	1.9	0.4	2.6
Schizophrenia (2018)	3.7	7.6	16.7	3.7	-4.1	1.8	-2.2	-1.1	-2.4
High blood pressure (mother)	3.7	5.1	8.5	-2.9	2.6	-2.8	1.7	-0.7	2.1
Bipolar Disorder or Schizophrenia	3.6	8.7	15.3	2.9	-3.8	0.0	-3.9	-2.6	-2.7
Blood White Count	3.6	26.9	65.9	-5.3	4.9	-8.1	-3.6	-5.5	-0.6
Medication: Paracetamol	3.6	6.0	9.6	-3.1	2.7	-2.9	1.0	-0.6	3.1
Stomach or abdominal pain in last month	3.3	4.1	8.4	-2.2	2.0	-2.9	-1.2	-2.0	1.5
Had other major operations	3.3	4.1	10.0	-2.6	1.3	-2.1	1.2	0.2	3.2
Number of treatments/medications taken	3.2	5.7	11.2	-2.9	3.3	-2.8	0.9	-0.5	2.4
Alcohol drinker status: Never	3.2	3.8	10.9	0.3	-0.9	-1.7	-3.3	-2.4	-1.5
Multivitamins +/- minerals	3.1	3.9	6.9	-2.6	2.0	-2.4	1.4	-0.8	2.1
Eye problems/disorders: Cataract	3.1	3.6	8.5	-2.3	2.9	-2.0	0.4	-0.3	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.5	9.7	-1.9	0.3	-3.1	-0.8	-2.2	1.5
Bipolar Disorder (2018)	2.9	4.6	12.5	0.1	-1.0	-2.2	-3.5	-2.8	-1.2
Schizophrenia (2014)	2.9	6.5	15.2	3.1	-3.9	1.0	-2.7	-1.4	-1.9
Neuroticism	2.9	6.9	12.5	-3.5	2.6	-3.4	1.3	-1.4	2.7
Illnesses of mother	2.8	3.5	7.2	2.6	-2.0	2.7	-0.7	1.2	-1.0
Eye problems/disorders: None of the above	2.8	3.2	6.6	2.3	-2.2	2.6	0.7	1.2	-0.8
Schizophrenia vs Biploar Disorder	2.6	3.4	7.1	2.0	-1.7	2.7	1.8	1.6	-0.6
Illnesses of siblings: Diabetes	2.6	3.1	8.1	1.6	0.8	2.8	1.0	2.6	-0.2
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	5.7	-2.4	2.0	-2.2	-0.0	-0.4	1.7
Illnesses of siblings	2.5	3.4	7.6	1.5	-2.8	0.3	-1.8	-1.7	-2.1
Lung cancer (father)	2.5	3.0	5.6	2.3	-0.5	0.9	-2.4	-1.1	-2.1
Migraine (self-reported)	2.5	3.1	6.3	-2.5	1.0	-2.5	1.4	-0.9	1.6
Pulse rate, automated reading	2.5	8.0	17.9	-0.0	0.6	-3.5	-3.8	-4.2	-1.8
Supplements: Vitamin C	2.5	2.9	5.4	-2.1	1.6	-0.6	1.6	1.4	2.3
Major Depression (MDD)	2.4	2.9	7.9	1.3	-2.8	0.3	-2.2	-1.1	-1.3
Townsend deprivation index at recruitment	2.4	3.3	7.1	2.7	-2.0	1.6	-1.9	-0.4	-1.6
High blood pressure (siblings)	2.4	3.5	6.0	-2.5	2.3	-2.0	1.1	-0.1	2.0
Medication: Paracetamol	2.4	3.7	6.9	-2.3	1.8	-2.4	0.5	-0.6	2.6
Diverticular disease/diverticulitis (self-reported)	2.3	2.7	7.6	-1.7	2.8	-0.9	1.8	0.4	1.2
Diabetes (mother)	2.2	2.8	5.9	0.6	0.7	2.1	2.3	2.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	6.4	2.0	-2.5	0.6	-1.8	-0.8	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	4.3	-1.8	1.8	-2.1	-0.1	-1.0	1.4
Supplements: Fish oil (including cod liver oil)	2.2	2.8	6.9	-2.6	1.2	-2.2	0.7	-0.8	1.7
Medication: Atorvastatin	2.2	2.7	6.5	-1.4	1.5	-2.5	-0.9	-2.0	0.5
Pulse rate	2.1	3.5	8.4	0.9	0.2	-1.1	-2.9	-2.2	-2.4
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	9.7	-1.0	2.4	0.7	3.1	1.8	0.7
Medication: Allopurinol	2.1	2.7	6.9	-1.8	2.1	-2.6	-0.5	-1.1	0.3
Medication: Simvastatin	2.0	3.0	8.8	-1.8	1.0	-3.0	-0.7	-2.1	-0.1
Ever highly irritable/argumentative for 2 days	2.0	2.4	5.4	-2.1	0.9	-2.3	-0.6	-1.3	1.4
Qualifications: nursing, teaching	2.0	3.2	7.1	-1.0	1.9	0.3	2.7	1.5	2.2
Medication for cholesterol	2.0	3.1	7.9	2.6	-1.3	2.8	-0.2	0.9	-1.2
Cholesterol lowering medication	2.0	2.9	7.7	-1.2	0.9	-2.8	-1.2	-2.4	-0.7
Hayfever, allergic rhinitis or eczema	1.9	4.1	14.7	-1.8	3.8	-0.7	1.8	1.1	1.4
Time employed in main current job	1.9	2.2	4.8	0.4	0.9	1.8	2.0	2.2	-0.4
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.1	-1.5	2.0	-0.6	1.5	0.8	2.0
Average weekly red wine intake	1.9	2.8	6.8	0.1	0.8	1.7	2.6	2.6	0.5
Financial situation satisfaction	1.9	2.4	5.0	-2.1	1.2	-1.3	1.3	0.1	2.2
Hair/balding pattern: Pattern 2	1.8	2.3	5.6	-1.7	0.5	-2.4	-1.4	-1.7	0.5
Depression (Nagel 2018)	1.7	2.6	5.4	-2.3	0.7	-2.3	0.4	-1.1	1.7
Allergy or Eczema	1.7	4.5	13.9	-1.9	3.7	-0.8	2.1	1.1	1.7
Diabetes (self-reported)	1.7	2.6	5.8	-0.2	-1.7	1.5	1.6	2.4	1.5
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.2	-1.1	0.9	-2.3	-1.2	-2.1	-0.4
Illnesses of father: High blood pressure	1.7	2.0	3.2	-1.4	1.7	-0.3	1.8	1.0	1.8
Fractured/broken bones in last 5 years	1.7	2.2	6.0	-1.3	2.4	-0.4	0.9	1.0	1.9
Unable to work because of sickness or disability	1.7	2.2	5.7	1.0	-2.4	-0.2	-1.7	-1.6	-0.9
Ever used hormone-replacement therapy (HRT)	1.6	2.0	10.6	0.8	-3.3	0.2	-0.5	-0.7	-0.2
Systolic blood pressure, automated reading	1.6	4.6	8.5	-2.6	2.9	-1.5	2.4	0.6	2.0
Medication: Ramipril	1.6	2.1	4.7	-1.0	0.9	0.4	2.2	1.8	1.6
Alcohol intake versus 10 years previously	1.6	2.3	3.7	-1.9	1.9	-1.2	1.4	0.4	1.7
Medication: Cholesterol lowering	1.6	2.5	6.5	-1.4	1.4	-2.5	-1.1	-1.8	-0.5
Health satisfaction	1.6	2.0	4.0	-1.8	2.0	-1.9	0.5	-0.7	0.9
Mood swings	1.6	3.0	4.5	-2.0	2.1	-1.9	1.3	-0.5	2.0
Average weekly beer plus cider intake	1.6	2.4	5.2	2.3	-1.8	1.2	-0.9	-0.7	-1.8
Prostate Cancer	1.5	2.0	4.8	0.3	-2.0	-1.4	-1.2	-2.2	-0.4
Bipolar Disorder (2011)	1.5	1.4	4.2	1.0	-0.3	-0.7	-2.0	-1.7	0.0
Neuroticism (2016)	1.5	2.1	4.6	-1.8	-0.2	-2.1	-0.5	-1.4	1.6
Systolic Blood Pressure	1.5	7.6	15.5	-3.9	3.7	-3.0	2.2	-0.3	1.6
Medication: Co-codamol	1.5	1.8	3.8	-0.7	-0.2	-1.9	-1.8	-1.7	-0.1
Mouth/teeth dental problems	1.5	2.3	6.5	1.3	0.0	2.5	1.2	2.1	-0.2
Mean time to correctly identify matches	1.5	2.8	7.7	0.7	0.8	2.3	1.6	2.8	0.5
Overall health rating	1.5	3.2	6.3	-0.2	1.7	-2.1	-2.5	-2.3	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.6	-1.4	1.2	-1.9	-0.9	-1.1	1.2
Smoking status: Current	1.5	2.3	5.0	1.4	-0.7	-0.1	-2.2	-1.4	-2.1
Miserableness	1.5	2.6	5.7	-1.8	1.2	-2.4	-0.3	-1.8	1.5
Maternal smoking around birth	1.4	2.0	4.3	2.1	-1.0	1.6	-1.6	0.4	-1.2
Medication: Amlodipine	1.4	1.9	4.5	-1.4	1.2	-0.6	2.1	0.7	1.7
Friendships satisfaction	1.4	1.8	3.5	-0.6	-0.4	-1.7	-1.9	-1.7	-0.9
Supplements: Calcium	1.4	1.6	4.1	-1.8	0.2	-2.0	-0.7	-0.8	0.9
Reaction Time	1.3	2.5	5.7	1.2	0.9	2.4	1.5	2.2	0.3
Waist Hip Ratio (WHR)	1.3	5.9	8.9	3.0	-2.9	0.4	-3.0	-1.8	-2.5
Supplements: Glucosamine	1.3	1.7	3.5	0.5	-1.3	-0.7	-1.9	-1.8	-1.1
Alcohol usually taken with meals	1.3	2.1	4.1	-2.0	1.6	-1.4	1.5	0.1	1.3
Pain all over the body in last month	1.3	1.4	3.0	-1.1	1.7	-0.4	0.9	0.9	1.5
Smoking status: Previous	1.3	1.9	4.8	-0.4	0.2	0.9	2.2	1.9	1.4
Commuting to job workplace: Public transport	1.3	1.5	2.3	0.9	-1.5	0.1	-1.3	-1.4	-1.4
Medication: Bendroflumethiazide	1.3	2.0	5.3	-1.4	-0.0	-2.3	-0.5	-2.1	-0.2
Depressed Affect (Nagel 2018)	1.2	2.5	5.3	-1.9	1.2	-2.3	0.6	-1.3	1.5
Ulcerative Colitis (UC)	1.2	2.2	4.0	-1.8	2.0	-1.7	1.1	-0.6	1.1
Hand grip strength (left)	1.2	3.2	6.0	2.5	-1.6	2.4	0.2	0.6	-2.1
Average weekly spirits intake	1.2	1.5	4.2	-1.2	-0.4	-2.0	-0.9	-1.5	-0.0
Supplements: Zinc	1.2	1.3	4.5	-1.0	0.5	-0.1	2.1	0.9	1.2
Impedance of leg (right)	1.2	6.0	10.2	-0.7	-3.0	-2.8	-2.3	-3.2	-1.9
Neuroticism score	1.2	2.5	4.9	-1.6	1.7	-2.2	0.3	-1.8	1.1
Qualifications: A levels/AS levels or equivalent	1.2	2.7	5.7	1.1	1.0	2.3	2.4	1.7	-0.2
Headache pain in last month	1.2	2.1	5.4	-1.5	2.3	-1.2	0.7	0.1	1.7
Had major operations	1.2	1.4	4.2	-2.0	0.4	-1.7	0.4	-0.8	0.5
Diabetes diagnosed by doctor	1.2	2.0	4.3	0.1	-1.6	1.5	1.0	2.1	1.3
Medication: Aspirin	1.2	1.5	2.5	-1.5	1.6	-0.7	1.4	0.5	1.2
Type 2 Diabetes (T2D) (2018)	1.1	2.1	5.1	1.2	-2.2	2.0	-0.5	1.3	0.0
Impedance of leg (left)	1.1	5.2	9.9	-0.8	-2.5	-2.9	-1.8	-3.1	-1.8
Prospective memory result	1.1	1.3	3.5	0.2	-0.1	0.9	1.4	1.2	1.9
Number of full sisters	1.1	1.4	2.9	1.7	-0.2	1.5	-0.4	1.0	-1.4
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.0	-1.7	1.0	-1.2	0.7	0.4	1.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.6	0.5	0.2	1.7	1.0	1.9	-0.4
Whole body fat-free mass	1.1	6.2	18.1	2.7	-0.2	4.2	1.4	2.9	1.0
Loneliness, isolation	1.1	1.5	3.7	-0.9	0.7	-1.9	-1.1	-1.6	0.4
Leg predicted mass (right)	1.1	5.8	16.1	2.6	0.2	4.0	1.6	2.9	0.9
Mother’s age at death	1.1	1.4	2.2	0.9	-1.3	1.5	1.2	1.1	-1.0
Lupus	1.0	1.4	4.6	-1.0	2.1	-0.1	0.8	1.0	1.1
Ulcerative Colitis	1.0	1.4	4.7	-1.1	2.2	-1.4	0.6	-0.4	0.2
Chronotype (morning person)	1.0	2.4	7.1	-0.7	-0.6	-1.8	-1.8	-2.7	-0.3
Medication: Metformin	1.0	1.4	3.0	1.2	-1.6	1.7	-0.0	1.2	0.5
Leg fat-free mass (left)	1.0	5.3	15.1	2.6	-0.1	3.9	1.2	2.8	0.9
Current tobacco smoking	1.0	1.7	4.2	1.0	-0.3	-0.3	-2.0	-1.4	-1.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.1	1.3	-1.0	0.6	-0.3	-0.4	-1.7
Leg predicted mass (left)	1.0	5.5	15.5	2.6	-0.1	3.9	1.3	2.8	0.9
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	4.0	-0.2	1.3	1.2	1.0	2.0	0.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	3.1	1.8	-1.8	1.7	-0.8	0.5	-0.4
Arm fat-free mass (right)	1.0	4.9	14.0	2.3	-0.5	3.7	1.1	2.8	1.1
Exposure to tobacco smoke outside home	1.0	1.3	2.9	-0.8	0.5	-1.7	-1.1	-1.7	0.4
Chest pain or discomfort	1.0	1.5	4.3	-0.3	0.7	-1.6	-1.2	-2.1	-0.0
Leg fat-free mass (right)	1.0	5.6	15.2	2.5	0.2	3.9	1.7	2.9	1.0
Mineral and other dietary supplements	1.0	1.3	3.2	1.4	-0.0	1.8	0.7	1.5	-0.2
Whole body water mass	1.0	5.5	16.2	2.5	-0.2	4.0	1.3	2.8	1.0
Basal cell carcinoma (self-reported)	1.0	1.2	1.7	-1.3	1.3	-1.0	1.3	-0.3	1.0
Ovarian Cancer	0.9	1.2	5.6	-0.4	2.4	-0.1	0.9	0.3	0.8
Cardiovascular Disease	0.9	3.0	8.0	-1.4	2.8	-2.3	-0.2	-1.6	0.3
Hearing difficulty/problems with background noise	0.9	1.4	4.1	-0.6	1.0	0.3	2.0	1.3	1.2
Trunk fat-free mass	0.9	5.2	15.8	2.5	-0.4	4.0	1.2	2.5	1.0
Trunk predicted mass	0.9	5.4	16.2	2.5	-0.4	4.0	1.3	2.6	1.0
Birth weight of first child	0.9	1.7	4.3	1.2	-2.1	0.6	-1.8	-0.5	-0.6
Glaucoma (self-reported)	0.9	1.0	2.3	0.6	-0.8	-0.6	-1.4	-1.5	-0.8
Comparative body size at age 10	0.9	2.5	6.5	-1.6	2.5	-1.1	0.9	0.3	2.0
Arm predicted mass (right)	0.9	4.5	12.4	2.0	-0.2	3.5	1.2	2.7	1.3
Comparative height size at age 10	0.9	5.1	12.7	2.2	-0.9	3.6	2.6	2.1	1.2
Medication: Aspirin	0.9	1.2	2.2	-1.5	1.4	-0.9	1.1	0.3	1.0
Hypertension (Self-reported)	0.9	2.5	6.8	-1.4	2.6	-0.8	1.9	0.6	1.3
Medication: Gliclazide	0.9	1.0	1.7	1.1	-1.3	1.2	-0.3	0.6	-1.0
Basal metabolic rate	0.9	4.8	14.0	2.5	-0.1	3.7	1.1	2.6	1.0
Pain experienced in last month	0.9	1.5	4.4	1.0	-2.1	1.0	0.0	-0.1	-1.7
Impedance of whole body	0.9	4.7	9.8	-0.4	-2.6	-2.6	-1.2	-3.1	-1.8
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.4	0.7	-0.1	1.6	1.0	1.3	-0.0
Height	0.8	15.1	36.2	4.4	-3.6	6.0	2.4	4.0	0.5
Taking other prescription medications	0.8	1.2	3.6	0.1	1.9	0.7	0.9	1.4	0.8
Sitting height	0.8	6.0	16.2	3.0	-1.8	4.0	1.9	2.0	-0.2
Worrier / anxious feelings	0.8	1.5	5.3	-0.5	2.3	0.4	1.4	1.0	0.6
Happiness	0.8	1.0	1.8	-1.4	0.8	-1.3	0.3	-0.3	1.2
Standing height	0.8	8.0	18.7	3.5	-2.9	4.3	2.0	2.0	0.4
Medication: Blood pressure	0.8	1.4	3.4	-1.3	1.9	-0.6	1.4	0.5	0.9
Illnesses of father: Heart disease	0.8	1.1	2.7	-1.2	0.7	-1.6	-1.1	-0.9	0.5
Osteoporosis (self-reported)	0.8	0.9	2.2	-0.8	1.5	-0.6	0.8	0.4	1.3
Ever taken oral contraceptive pill	0.8	0.9	2.1	0.4	0.8	1.1	1.1	1.4	0.4
Irritable Bowel Disease (IBD)	0.7	1.7	5.8	-1.2	2.4	-1.3	0.8	-0.5	0.6
Blood Eosinophil Count	0.7	5.1	15.3	-2.8	3.9	-1.8	0.7	-0.1	2.0
Hair Pigment	0.7	18.6	54.9	-4.3	7.4	-4.3	1.5	-1.4	3.9
Sensitivity / hurt feelings	0.7	1.1	2.1	-1.4	1.0	-1.2	0.3	-0.4	1.4
Severe depression (siblings)	0.7	0.8	2.5	-0.5	0.6	0.2	0.9	0.9	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.1	-1.4	0.7	-1.0	0.3	-0.3	1.4
High blood pressure	0.7	1.9	5.2	-1.3	2.3	-1.1	1.4	-0.0	1.0
Past tobacco smoking	0.7	1.2	3.6	0.5	-0.1	-0.5	-1.9	-1.4	-1.0
Heart attack	0.7	0.9	2.8	-0.1	1.3	0.8	0.5	1.7	0.5
Allergy	0.7	1.6	6.8	1.1	-2.6	0.6	-0.5	-0.6	-0.7
Impedance of arm (right)	0.7	3.1	7.2	0.2	-2.0	-1.9	-0.8	-2.7	-1.8
Impedance of arm (left)	0.7	3.2	6.8	0.1	-2.3	-1.9	-0.7	-2.6	-1.8
Number of full brothers	0.7	0.9	2.2	-0.2	-1.5	-0.9	-1.2	-1.0	0.4
Long-standing illness, disability or infirmity	0.7	1.1	3.2	-1.0	1.2	-0.6	0.4	0.4	1.8
Number of self-reported non-cancer illnesses	0.7	1.3	4.2	-1.2	2.1	-1.1	0.4	0.1	0.9
Average weekly champagne plus white wine intake	0.7	1.0	3.1	0.8	0.3	1.8	0.3	1.4	-0.1
Hearing aid user	0.7	0.7	3.1	0.9	0.4	0.7	-0.2	-0.1	-1.8
Arm fat-free mass (left)	0.7	3.4	9.8	2.0	-0.3	3.1	0.8	2.1	1.0
Diastolic blood pressure, automated reading	0.7	2.1	3.6	-1.6	1.8	-0.8	1.9	0.5	1.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.9	0.1	1.2	0.9	0.1	1.7	0.3
Arm predicted mass (left)	0.7	3.4	9.7	2.0	-0.3	3.1	0.9	2.2	1.0
Medication for hormone replacement therapy	0.6	0.7	1.7	-0.5	-0.6	-1.3	-0.6	-0.8	0.9
Fed-up feelings	0.6	1.1	4.1	0.0	0.9	-1.2	-0.6	-2.0	0.3
Serious illness, injury or assault to yourself	0.6	0.7	1.2	-0.9	1.0	-1.1	-0.6	-0.5	0.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	1.8	-0.4	-0.5	-1.4	-0.7	-1.3	0.1
Financial difficulties in last 2 years	0.6	0.8	3.0	0.2	-0.7	-0.9	-0.1	-1.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.8	-0.2	1.0	-1.4	-0.7	-1.7	0.2
Falls in the last year	0.6	0.9	1.6	-0.8	0.6	-1.3	-1.0	-0.6	1.1
Breastfed as a baby	0.6	0.7	1.2	-1.1	-1.1	-0.2	0.7	0.7	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.9	-1.3	-0.1	-1.4	0.3	-0.5	1.2
Hair/balding pattern: Pattern 4	0.6	1.4	2.5	1.0	-1.4	1.3	-0.3	1.0	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	1.2	0.9	-0.6	1.1	-0.0	1.0	-0.8
Age at first live birth	0.6	1.1	2.3	-0.9	1.4	-0.1	1.5	0.8	0.9
Angina (self-reported)	0.6	0.8	3.2	1.1	0.3	0.3	-0.5	-0.3	-1.8
Medication: Seretide 50 evohaler	0.6	0.7	1.5	1.1	-0.1	1.2	-0.5	1.2	-0.0
Heart disease (mother)	0.6	0.7	1.4	-0.9	1.1	-1.2	0.2	-0.8	-0.3
Guilty feelings	0.6	0.9	1.7	-0.5	0.4	-1.1	-0.8	-1.3	1.3
Medication: Blood pressure	0.6	1.2	2.3	-1.5	1.2	-1.1	1.3	-0.1	0.9
Ever depressed for a whole week	0.6	0.8	1.5	-0.3	-0.8	-1.1	-1.2	-1.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	-1.0	1.2	-0.6	0.6	0.2	1.1
Age at First Birth	0.5	0.7	2.2	-1.5	0.2	-1.2	0.3	-0.4	0.5
LDL Cholesterol	0.5	0.7	1.0	0.8	-1.0	0.1	-1.0	-0.8	-1.0
Rheumatoid Arthritis	0.5	0.7	2.4	-0.1	0.0	0.6	1.5	1.0	0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.2	-0.5	0.6	0.5	0.9	1.1	0.9
Angina	0.5	0.7	2.7	0.9	0.5	0.3	-0.3	-0.2	-1.6
Pack years adult smoking proportion	0.5	0.7	1.7	-0.7	-0.0	-1.1	-0.8	-0.7	1.3
Hand grip strength (right)	0.5	1.4	2.5	1.5	-1.4	1.6	0.4	0.2	-1.1
Relative age voice broke	0.5	0.7	1.5	0.4	1.2	0.6	1.2	0.8	-0.3
Weight	0.5	2.5	6.9	2.1	-0.5	2.6	0.4	1.7	0.6
Mouth/teeth dental problems: Dentures	0.5	0.8	1.9	-1.3	0.3	-1.4	0.3	-0.7	0.8
Length of working week for main job	0.5	0.5	1.7	-0.9	-0.1	-0.3	0.7	0.4	1.3
Leg pain on walking	0.5	0.6	1.4	-0.7	0.1	-1.2	-0.9	-1.1	-0.3
Back pain experienced in last month	0.5	0.7	2.1	-0.6	1.4	-0.7	0.4	-0.3	0.9
Age started oral contraceptive pill	0.5	0.7	1.1	1.1	-0.6	0.9	-0.7	0.5	-1.0
Commuting to job workplace: Cycle	0.5	0.6	1.7	-1.2	0.4	-0.7	-0.1	0.1	1.3
Vascular/heart problems diagnosed by doctor	0.5	1.5	4.7	1.0	-2.2	0.9	-1.4	-0.1	-0.7
Heart disease (siblings)	0.5	0.6	2.2	0.1	0.3	-0.8	-1.5	-0.7	-0.4
HbA1C	0.4	0.4	1.1	-0.8	0.5	-0.4	0.5	0.5	1.0
Tanning	0.4	4.8	10.7	1.6	-1.5	3.1	1.8	3.3	0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.1	-0.7	0.7	-1.1	-0.0	-1.0	0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.5	0.3	-1.1	-0.6	-0.8	-0.3
Diabetes (father)	0.4	0.5	1.1	-0.2	-0.6	0.7	0.5	0.8	1.0
Number of incorrect matches in round	0.4	0.6	1.5	0.2	-0.7	0.8	0.8	1.2	0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	0.9	0.5	0.6	-0.5	0.2	-1.0
Birth weight	0.4	0.8	2.0	-1.0	1.1	-0.5	0.4	0.4	1.4
Worry too long after embarrassment	0.4	0.7	2.9	-0.2	1.7	-0.3	0.7	-0.7	-0.2
Qualifications: College or University degree	0.4	1.2	3.4	-0.1	1.0	0.8	1.8	1.3	0.7
Emphysema/chronic bronchitis	0.4	0.4	1.0	-0.1	-0.4	-0.5	-0.4	-0.9	-1.0
Medication: Omeprazole	0.4	0.5	1.0	-0.8	1.0	-0.3	0.3	0.4	1.0
Suffer from ‘nerves’	0.4	0.6	1.1	-1.0	0.3	-1.1	0.3	-0.9	0.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.0	0.7	-1.0	0.2	-0.3	-0.5	-1.0
Ever had bowel cancer screening	0.4	0.5	1.2	-0.1	0.6	0.4	0.8	0.9	1.1
Commuting to job workplace: Walk	0.4	0.4	1.4	-0.7	0.1	-0.0	1.2	0.5	0.6
Breast cancer (self-reported)	0.4	0.5	1.7	-0.6	0.6	-0.0	1.3	0.6	0.6
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	0.8	-0.5	0.0	-1.0	-0.7	-0.5
Ever smoked	0.4	0.6	1.8	-0.8	0.2	0.0	1.3	0.9	0.8
Irritability	0.4	0.6	2.0	0.6	1.4	0.1	1.1	-0.3	-0.0
Neuroticism (Nagel 2018)	0.3	0.8	1.4	-0.9	0.7	-1.2	0.7	-0.7	0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.6	-1.0	-0.6	-0.4	1.6	-0.5	0.1
Primary Biliary Cirrhosis	0.3	0.4	1.3	0.3	1.1	0.3	-0.1	0.4	-0.7
Blood Red Count	0.3	3.1	13.5	-1.8	3.7	-1.2	-0.1	0.5	0.7
Respiratory disease	0.3	0.6	1.5	0.7	-0.6	0.3	-1.2	-0.1	-1.1
Relative age of first facial hair	0.3	0.7	1.8	-0.1	-0.2	-0.7	-0.7	-1.1	-1.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	-0.0	-0.6	-0.7	-0.8	-0.6	0.0
Medication: Levothyroxine sodium	0.3	0.5	1.1	-1.0	1.1	-0.2	0.4	0.6	0.7
Trunk fat mass	0.3	1.2	3.5	1.9	-1.1	1.3	-0.6	0.4	-0.3
Father’s age at death	0.3	0.5	1.2	0.5	0.1	1.1	0.8	0.8	0.0
Hair/balding pattern: Pattern 3	0.3	0.5	2.2	0.5	-1.5	0.3	0.1	-0.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.6	-0.4	-0.7	-0.8	-0.8	-0.3	0.3
Asthma	0.3	0.6	0.8	0.8	-0.4	0.9	-0.9	0.8	-0.8
Exposure to tobacco smoke at home	0.3	0.3	1.1	0.2	0.2	0.7	0.1	1.1	0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	-0.5	-0.1	-0.9	-0.1	-0.6	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.5	0.4	1.2	0.5	0.2	0.7	-0.2
Family relationship satisfaction	0.3	0.3	1.5	0.1	-1.2	-0.1	-0.5	-0.1	-0.4
Knee pain experienced in last month	0.3	0.5	1.1	-0.8	-0.4	-1.1	0.3	-0.5	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	-0.8	0.8	-0.8	-0.0	0.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	0.7	-0.5	1.1	0.7	0.7	0.8
Osteoarthritis (self-reported)	0.3	0.4	1.3	-1.1	-0.1	-0.7	-0.2	0.4	0.6
Myopia	0.3	0.5	1.0	-0.7	-0.8	-1.0	-0.4	-0.8	0.0
Pack years of smoking	0.3	0.5	1.1	-0.6	-0.4	-0.8	-0.5	-0.4	1.1
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.3	-1.0	-0.0	-0.6	1.5	-0.6	0.4
Worry (Nagel 2018)	0.2	0.5	0.8	-0.8	0.7	-0.9	0.7	-0.6	0.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	-0.4	0.3	-0.4	0.7	-0.2	-0.4
Crohns Disease (2017)	0.2	0.5	2.3	-0.1	1.5	-0.4	-0.1	-0.3	-0.5
Breast Cancer	0.2	0.6	1.3	-0.6	-0.7	-1.1	-0.4	-1.0	0.4
Crohns Disease (2012)	0.2	0.3	0.6	-0.6	0.7	-0.7	0.0	-0.3	0.1
Mean Putamen Volume	0.2	0.3	0.5	0.6	-0.7	0.4	0.6	0.2	-0.4
HDL Cholesterol	0.2	0.4	0.9	-1.0	-0.1	-0.7	-0.4	0.1	0.8
Heel T-Score	0.2	1.2	2.5	1.4	-1.5	1.6	0.4	0.6	-0.1
Smoking Status	0.2	0.5	0.8	0.9	-0.8	0.2	-0.8	-0.3	-0.9
Lung FEV1/FVC ratio	0.2	0.9	2.3	0.7	-0.3	-0.2	-0.6	-1.4	-1.5
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.5	0.7	0.5	0.6	0.4	-0.1
Average weekly fortified wine intake	0.2	0.2	0.7	-0.8	-0.2	-0.5	0.5	0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	2.0	0.7	-1.4	0.8	0.1	-0.0	-0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.5	-0.0	-0.6	-0.5	-0.5	0.7
Medication: Atenolol	0.2	0.2	0.6	-0.2	0.8	0.1	0.7	0.2	-0.2
Chronic bronchitis/emphysema (father)	0.2	0.3	1.3	0.2	-0.2	-0.2	-1.1	0.0	0.3
Waist circumference	0.2	0.7	2.2	1.5	-0.7	0.8	-0.7	-0.0	-0.2
Nervous feelings	0.2	0.3	1.1	-0.4	0.4	-0.2	1.1	-0.1	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.6	-0.1	0.8	-0.5	0.4	-0.4	0.6
Forced vital capacity (FVC)	0.2	0.7	1.6	1.3	-1.1	0.8	-0.1	-0.6	-0.5
Hip circumference	0.2	0.8	3.4	-0.2	0.7	0.2	0.8	0.6	1.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	1.0	-0.5	0.1	-0.5	-1.3	-0.8
Medication: Lansoprazole	0.2	0.2	0.7	-0.6	0.3	-0.8	-0.1	-0.4	0.2
Tense / ‘highly strung’	0.2	0.3	1.1	0.1	0.0	-0.7	-0.2	-1.0	0.1
Peak expiratory flow (PEF)	0.2	0.4	1.0	0.4	0.9	-0.3	-0.3	-1.0	-0.2
Loud music exposure frequency	0.2	0.2	0.6	0.8	0.0	0.6	-0.2	0.1	-0.2
Body fat percentage	0.2	0.7	1.9	0.8	-0.7	-0.3	-1.4	-0.7	-0.7
Leg fat percentage (right)	0.2	0.8	3.5	0.3	-0.5	-0.6	-1.9	-0.6	-0.4
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	0.4	1.0	-0.0	-1.1	-0.3	-0.2
Pulse wave peak to peak time	0.2	0.2	0.5	0.1	-0.4	0.6	0.7	0.3	-0.3
Neck or shoulder pain in last month	0.2	0.3	1.2	-0.5	0.8	-0.2	-0.1	0.2	1.1
Whole body fat mass	0.2	0.8	2.4	1.6	-0.8	1.1	-0.8	0.3	-0.2
Leg fat mass (right)	0.2	1.0	2.2	1.5	-0.7	1.2	-1.1	0.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.2	0.5	-0.2	0.7	-0.7	-0.6	-0.3	0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.2	0.6	0.2	0.9	0.0	-0.1
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.3	-0.6	0.5	-0.4	-0.3	-0.4	0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.3	-0.2	-0.6	-0.6	-0.6	-0.5	-0.2
Medication: Lisinopril	0.2	0.2	0.6	-0.4	0.7	-0.2	0.8	-0.3	0.1
Risk taking	0.2	0.2	0.5	0.7	-0.5	0.2	-0.1	-0.2	0.7
Alcohol drinker status: Previous	0.2	0.3	0.5	0.6	-0.1	0.7	-0.4	0.7	0.3
Leg fat mass (left)	0.2	0.8	2.0	1.4	-0.4	1.2	-0.8	0.7	-0.2
Alzheimer’s Disease (in father)	0.1	0.2	0.4	0.7	-0.1	0.6	0.1	0.3	-0.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.6	0.2	-0.8	0.0	0.5	-0.2	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.5	0.1	-0.0	0.4	0.7	0.4	0.0
BMI	0.1	0.7	1.7	1.2	0.6	1.3	-0.5	0.8	-0.2
Hypothyroidism (self reported)	0.1	0.3	0.9	-0.1	0.9	0.6	0.5	0.7	-0.2
Lung FVC	0.1	0.7	2.6	0.0	-0.0	-0.7	-1.6	-0.8	-0.8
Trunk fat percentage	0.1	0.5	1.0	1.0	-1.0	-0.1	-0.9	-0.4	-0.4
Body mass index (BMI)	0.1	0.4	0.9	0.4	0.9	0.5	-0.6	0.7	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	0.4	-1.0	0.6	0.5	0.3	-0.2
Qualifications: None of the above	0.1	0.2	1.1	0.1	-1.1	-0.1	-0.5	-0.2	0.2
Fluid intelligence score	0.1	0.3	1.0	-1.0	-0.3	-0.2	0.6	-0.1	-0.1
Arm fat percentage (right)	0.1	0.4	1.7	0.7	0.0	-0.2	-1.3	-0.5	-0.5
Number of live births	0.1	0.2	0.4	0.2	0.7	0.2	-0.5	0.3	0.3
Noisy workplace	0.1	0.1	0.4	0.2	-0.7	0.3	-0.3	0.1	-0.2
Depression (self-reported)	0.1	0.1	0.5	-0.2	-0.2	0.1	0.4	0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.6	0.6	-0.5	0.2	-0.0	-0.8	-0.3
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.0	0.3	-0.4	-0.4	-0.1	0.5
Arm fat mass (right)	0.1	0.6	1.8	1.4	-0.2	1.1	-0.6	0.4	0.0
Pulse wave reflection index	0.1	0.2	0.4	0.3	-0.6	0.1	-0.1	0.0	0.7
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.6	0.6	-0.5	-0.1	-0.0	0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	1.1	1.0	-1.1	0.7	0.1	-0.5	-0.3
Number of children fathered	0.1	0.2	0.4	0.2	-0.3	-0.5	-0.4	-0.7	0.2
Arm fat percentage (left)	0.1	0.5	1.8	0.8	-0.1	-0.0	-1.4	-0.4	-0.6
Asthma (self-reported)	0.1	0.3	0.7	0.4	-0.2	0.5	-0.9	0.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.5	0.1	0.2	0.2	0.2	-0.0	-0.7
Arm fat mass (left)	0.1	0.5	1.5	1.2	-0.2	0.8	-0.8	0.2	-0.0
Wears glasses or contact lenses	0.1	0.2	0.3	-0.4	0.3	0.2	0.3	0.6	0.4
Leg fat percentage (left)	0.1	0.5	2.1	0.2	-0.1	-0.5	-1.5	-0.4	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.3	0.5	0.1	0.3	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.4	0.5	-0.3	-0.1	-0.1	0.1
Alzheimer’s Disease (including proxy)	0.0	0.1	0.2	0.0	-0.3	0.0	0.4	0.1	-0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.4	0.0	-0.3	0.1	-0.3	0.1	-0.6
Shortness of breath walking on level ground	0.0	0.1	0.2	0.1	-0.4	-0.3	-0.2	-0.2	0.1
Age at last live birth	0.0	0.0	0.1	-0.2	-0.1	-0.1	0.2	0.1	0.4

Hub : Genes

CAD

Models

Trait associations